13838-1-AP

antibody from Proteintech Group

Targeting: TCF7L2 TCF-4, TCF4

Provider product page for 13838-1-AP

Western blot

ELISA

Immunoprecipitation

Antibody data

Antibody Data
Antigen structure
References [40]
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Validations
Western blot [1]

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Product number: 13838-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#13838-1-AP, RRID:AB_2199812
Product name: TCF4/TCF7L2 antibody
Antibody type: Polyclonal
Description: TCF4/TCF7L2 antibody (Cat. #13838-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

TCF7L2 protein structure - 13838-1-AP shown in red.

Submitted references ATP-binding cassette subfamily A member 5 suppresses pancreatic ductal adenocarcinoma progression and chemoresistance by promoting β-catenin ubiquitin-dependent degradation.

Li Z, Ma Z, Chen Y, Yu W, Yu J, Lu J, Zhang Q, Wu Q, Cai Y, Wang Z, Shang C, Hou B, Zhang C, Huang S, Wang L, Zhou Q
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2026 May;86:101381

TCF7L2/DEPDC1 axis contributes to tumor progression by promoting cell proliferation, aerobic glycolysis, and immunosuppression in pancreatic cancer.

Tasiheng Y, Kenjiabieke J, Tasiheng N, Adilijiang K, Cheng H
Clinical and experimental medicine 2026 Mar 19;26(1)

Circadian Clock Dysfunction Exacerbate Autistic-Like Behaviour and Wnt/β-Catenin Signalling Dysregulation in ASD Mice and Treatment of Melatonin.

Zhang Y, Chen Y, Li W, Tang L, Wang G, Li J, Feng X
Journal of cellular and molecular medicine 2026 Jan;30(1):e70991

Wnt/β-Catenin Activation by iCRT3 Enhanced the Pluripotency of Bovine Expanded Pluripotent Stem Cells.

Liu D, Qu B, Wang J, Han X, Su M, Li X, Li Y, Li X
Animals : an open access journal from MDPI 2026 Feb 9;16(4)

Nanoceria drive stem cell hepatic differentiation and microenvironment remodeling for acute liver failure therapy.

Li F, Chen G, Xue T, Jiang Y, Chai Y, Yi K, Xu Y, Jin Y, Zhang Y, Luo Y, Wang H, Ju E, Chen Z, Xie X, Hou Y, Shuai X, Li K, Li M, Tao Y
Journal of controlled release : official journal of the Controlled Release Society 2026 Apr 10;392:114715

Multisensory gamma stimulation enhances adult neurogenesis and improves cognitive function in male mice with Down Syndrome.

Islam MR, Jackson B, Naomi MT, Schatz B, Tan N, Murdock M, Park DS, Amorim DR, Jiang X, Pineda SS, Adaikkan C, Fernandez Avalos V, Geigenmuller U, Firenze RM, Kellis M, Boyden ES, Tsai LH
PloS one 2025;20(4):e0317428

Rhein suppresses osteosarcoma progression via modulating the miR-328-3p/TCF7L2/FABP4 axis.

Zhao X, Wang R, Xia X, Han C, Wei W, Zhao W, Ji R, Zhang L
Biochemical pharmacology 2025 Nov;241:117152

USP30-AS1 Dictates Breast Cancer Cell Fate and Chemoresistance via a miR-3646/FZD7/Wnt/β-Catenin Circuit.

He Q, Yang S, Xin Q, Jiang Y, Jiang L, Xu N
Current issues in molecular biology 2025 Nov 24;47(12)

Single-cell sequencing reveals a senescent immune landscape in bone marrow lesions inducing articular cartilage damage in osteoarthritis.

Lou P, Lu X, Li M, Yao Y, Shao X, Shou D, Fan X, Tong P, Zhang Y
Bone research 2025 Nov 21;13(1):94

The opposite effect of ELP4 and ZEB2 on TCF7L2-mediated microglia polarization in ischemic stroke.

Min XL, Lin S, Hu JY, Jing R, Zhao Q, Shang FF, Zeng Y
Journal of cell communication and signaling 2025 Mar;19(1):e12061

Interaction of PHGDH with IGF2BP1 facilitates m6A-dependent stabilization of TCF7L2 mRNA to confer multidrug resistance in gastric cancer.

Chen S, Li T, Liu D, Liu Y, Long Z, Wu Y, Zhong Y, Zhao J, Wu T, He W, Cao T, Fan D, Wu K, Lu Y, Zhao X
Oncogene 2025 Jul;44(25):2064-2077

Targeted inhibition of menin promotes β-catenin-mediated GLP-1 expression and improves glucose tolerance in high-fat diet-induced obese mice.

Cao X, Yu L, Zhang Q, Cheng Z, Meng H, Wang C, Guo Z, Guo Y, Xin G, Wang Y, Zhou P, Luo Y, Sun B, Ma J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Feb 15;39(3):e70370

A single-cell transcriptomic atlas reveals senescence and inflammation in the post-tuberculosis human lung.

Sun G, Li K, Ping J, Zhao L, Cui C, Wu J, Xie L, Yao X, Xu G, Ma S, Fan Y, Wang Q, Yang D, Luo B, Liu H, Yang J, Zhang W, Song W, Zhao G, Fu X, Bian XW, Qu J, Wang S, Chen H, Liu GH
Nature microbiology 2025 Aug;10(8):2073-2091

TCF7L2 regulates GPX4 to resist ferroptosis and enhance osteogenesis in mouse mesenchymal stem cells.

Lei M, Liu B, Wan B, Feng Y, Teng Y, Xi D, Zeng G, Zong S
European journal of medical research 2025 Aug 5;30(1):713

Neuronal TCF7L2 in Lateral Habenula Is Involved in Stress-Induced Depression.

Li X, Liu X, Liu J, Zhou F, Li Y, Zhao Y, Yin X, Shi Y, Shi H
International journal of molecular sciences 2024 Nov 19;25(22)

Transcription factor 4 promotes increased corneal endothelial cellular migration by altering microtubules in Fuchs endothelial corneal dystrophy.

Yan J, Mehta S, Patel K, Dhupar N, Little N, Ong Tone S
Scientific reports 2024 May 4;14(1):10276

Single-cell analysis reveals that TCF7L2 facilitates the progression of ccRCC via tumor-associated macrophages.

Guo F, Gao Y, Zhou P, Wang H, Ma Z, Wang X, Wang X, Feng X, Wang Y, Han Z
Cellular signalling 2024 Dec;124:111453

Lactate drives the ESM1-SCD1 axis to inhibit the antitumor CD8(+) T-cell response by activating the Wnt/β-catenin pathway in ovarian cancer cells and inducing cisplatin resistance.

Fan Z, Ye M, Liu D, Zhou W, Zeng T, He S, Li Y
International immunopharmacology 2024 Aug 20;137:112461

Targeting aberrant glycosylation to modulate microglial response and improve cognition in models of Alzheimer's disease.

Wang Y, Du Y, Huang H, Cao Y, Pan K, Zhou Y, He J, Yao W, Chen S, Gao X
Pharmacological research 2024 Apr;202:107133

BCAS2 Participates in Insulin Synthesis and Secretion via mRNA Alternative Splicing in Mice.

Chen X, Xie X, Li J, Sun L, Lv Z, Yao X, Li L, Jin H, Cui S, Liu J
Endocrinology 2023 Nov 20;165(1)

MESP2 binds competitively to TCF4 to suppress gastric cancer progression by regulating the SKP2/p27 axis.

Ge L, Zhao G, Lan C, Song H, Qi D, Huang P, Ke X, Cui H
Cell death discovery 2023 Mar 1;9(1):79

Construction of a prognostic model for triple-negative breast cancer based on immune-related genes, and associations between the tumor immune microenvironment and immunological therapy.

Zhu Y, Tao LF, Liu JY, Wang YX, Huang H, Jiang YN, Qian WF
Cancer medicine 2023 Jul;12(14):15704-15719

TRIM27 maintains gut homeostasis by promoting intestinal stem cell self-renewal.

Wang J, Zhao D, Lei Z, Ge P, Lu Z, Chai Q, Zhang Y, Qiang L, Yu Y, Zhang X, Li B, Zhu S, Zhang L, Liu CH
Cellular & molecular immunology 2023 Feb;20(2):158-174

FGF9 Promotes Expression of HAS2 in Palatal Elevation via the Wnt/β-Catenin/TCF7L2 Pathway.

Sun Y, Ying X, Li R, Weng M, Shi J, Chen Z
Biomolecules 2022 Nov 4;12(11)

The WNT/Ca(2+) pathway promotes atrial natriuretic peptide secretion by activating protein kinase C/transforming growth factor-β activated kinase 1/activating transcription factor 2 signaling in isolated beating rat atria.

Li ZY, Liu Y, Han ZN, Li X, Wang YY, Cui X, Zhang Y
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2022 Nov 1;26(6):469-478

MicroRNA-22-3p targeted regulating transcription factor 7-like 2 (TCF7L2) constrains the Wnt/β-catenin pathway and malignant behavior in osteosarcoma.

Xue Y, Guo Y, Liu N, Meng X
Bioengineered 2022 Apr;13(4):9135-9147

Twist1 Contributes to the Maintenance of Some Biological Properties of Dermal Papilla Cells in vitro by Forming a Complex With Tcf4 and β-Catenin.

Yu N, Hu T, Yang H, Zhang L, Song Q, Xiang F, Yang X, Li Y
Frontiers in cell and developmental biology 2020;8:824

Modulation of Wnt/β-catenin signaling in IL-17A-mediated macrophage polarization of RAW264.7 cells.

Yuan C, Yang D, Ma J, Yang J, Xue J, Song F, Liu X
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 2020;53(8):e9488

Ginsenoside Rg1 Improves Differentiation by Inhibiting Senescence of Human Bone Marrow Mesenchymal Stem Cell via GSK-3β and β-Catenin.

Wang Z, Jiang R, Wang L, Chen X, Xiang Y, Chen L, Xiao M, Ling L, Wang Y
Stem cells international 2020;2020:2365814

Stimulation of endothelial progenitor cells by microRNA-31a-5p to induce endothelialization in an aneurysm neck after coil embolization by modulating the Axin1-mediated β-catenin/vascular endothelial growth factor pathway.

Yu G, Liu P, Shi Y, Li S, Liu Y, Fan Z, Zhu W
Journal of neurosurgery 2020 Sep 1;133(3):918-926

Wnt/β-Catenin Signaling Axis Is Required for TFEB-Mediated Gastric Cancer Metastasis and Epithelial-Mesenchymal Transition.

Li S, Liu F, Xu L, Li C, Yang X, Guo B, Gu J, Wang L
Molecular cancer research : MCR 2020 Nov;18(11):1650-1659

The Wnt/β-catenin/VASP positive feedback loop drives cell proliferation and migration in breast cancer.

Li K, Zhang J, Tian Y, He Y, Xu X, Pan W, Gao Y, Chen F, Wei L
Oncogene 2020 Mar;39(11):2258-2274

Computational and functional analyses of T2D GWAS SNPs for transcription factor binding.

Cheng M, Huang X, Zhang M, Huang Q
Biochemical and biophysical research communications 2020 Mar 12;523(3):658-665

Adiponectin Suppresses Human Pancreatic Cancer Growth through Attenuating the β-Catenin Signaling Pathway.

Jiang J, Fan Y, Zhang W, Shen Y, Liu T, Yao M, Gu J, Tu H, Gan Y
International journal of biological sciences 2019;15(2):253-264

miR-10b promoted melanoma progression through Wnt/β-catenin pathway by repressing ITCH expression.

Wang S, Wu Y, Xu Y, Tang X
Gene 2019 Aug 20;710:39-47

Wenyang Huazhuo Tongluo formula inhibits fibrosis via suppressing Wnt/β-catenin signaling pathway in a Bleomycin-induced systemic sclerosis mouse model.

Wang Q, Zang W, Han L, Yang L, Ye S, Ouyang J, Zhang C, Bi Y, Zhang C, Bian H
Chinese medicine 2018;13:17

Anticancer activity and potential mechanisms of 1C, a ginseng saponin derivative, on prostate cancer cells.

Wang X, Su GY, Zhao C, Qu FZ, Wang P, Zhao YQ
Journal of ginseng research 2018 Apr;42(2):133-143

HBP1-mediated Regulation of p21 Protein through the Mdm2/p53 and TCF4/EZH2 Pathways and Its Impact on Cell Senescence and Tumorigenesis.

Chen Y, Pan K, Wang P, Cao Z, Wang W, Wang S, Hu N, Xue J, Li H, Jiang W, Li G, Zhang X
The Journal of biological chemistry 2016 Jun 10;291(24):12688-12705

TCF7L2 involvement in estradiol- and progesterone-modulated islet and hepatic glucose homeostasis.

Dong F, Ling Q, Ye D, Zhang Z, Shu J, Chen G, Fei Y, Li C
Scientific reports 2016 Apr 25;6:24859

Smad6 suppresses the growth and self-renewal of hepatic progenitor cells.

Ding ZY, Liang HF, Jin GN, Chen WX, Wang W, Datta PK, Zhang MZ, Zhang B, Chen XP
Journal of cellular physiology 2014 May;229(5):651-60

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The TCF7L2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human TCF7L2. This antibody recognizes human, mouse, rat antigen. The TCF7L2 antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 13838-1-AP.pdf

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