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- References [7]
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- Western blot [1]
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- Product number
- 12467-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12467-1-AP, RRID:AB_11232403
- Product name
- RHBDL2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated RHBDL2 antibody (Cat. #12467-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Rhomboid-like 2 correlated with TME infiltration inhibits cuproptosis-related genes and drives malignant phenotype in clear cell renal cell carcinoma.
RHBDL2 promotes the proliferation, migration, and invasion of pancreatic cancer by stabilizing the N1ICD via the OTUD7B and activating the Notch signaling pathway.
Conformational surveillance of Orai1 by a rhomboid intramembrane protease prevents inappropriate CRAC channel activation.
Membrane Protein Dimerization in Cell-Derived Lipid Membranes Measured by FRET with MC Simulations.
Rhomboid-Like-2 Intramembrane Protease Mediates Metalloprotease-Independent Regulation of Cadherins.
A cellular complex of BACE1 and γ-secretase sequentially generates Aβ from its full-length precursor.
Quantitative proteomics screen identifies a substrate repertoire of rhomboid protease RHBDL2 in human cells and implicates it in epithelial homeostasis.
Che Z, Jin W, Wu Y, Li H, Liang P
Scientific reports 2024 Nov 7;14(1):27053
Scientific reports 2024 Nov 7;14(1):27053
RHBDL2 promotes the proliferation, migration, and invasion of pancreatic cancer by stabilizing the N1ICD via the OTUD7B and activating the Notch signaling pathway.
Chen S, Cai K, Zheng D, Liu Y, Li L, He Z, Sun C, Yu C
Cell death & disease 2022 Nov 9;13(11):945
Cell death & disease 2022 Nov 9;13(11):945
Conformational surveillance of Orai1 by a rhomboid intramembrane protease prevents inappropriate CRAC channel activation.
Grieve AG, Yeh YC, Chang YF, Huang HY, Zarcone L, Breuning J, Johnson N, Stříšovský K, Brown MH, Parekh AB, Freeman M
Molecular cell 2021 Dec 2;81(23):4784-4798.e7
Molecular cell 2021 Dec 2;81(23):4784-4798.e7
Membrane Protein Dimerization in Cell-Derived Lipid Membranes Measured by FRET with MC Simulations.
Škerle J, Humpolíčková J, Johnson N, Rampírová P, Poláchová E, Fliegl M, Dohnálek J, Suchánková A, Jakubec D, Strisovsky K
Biophysical journal 2020 Apr 21;118(8):1861-1875
Biophysical journal 2020 Apr 21;118(8):1861-1875
Rhomboid-Like-2 Intramembrane Protease Mediates Metalloprotease-Independent Regulation of Cadherins.
Battistini C, Rehman M, Avolio M, Arduin A, Valdembri D, Serini G, Tamagnone L
International journal of molecular sciences 2019 Nov 27;20(23)
International journal of molecular sciences 2019 Nov 27;20(23)
A cellular complex of BACE1 and γ-secretase sequentially generates Aβ from its full-length precursor.
Liu L, Ding L, Rovere M, Wolfe MS, Selkoe DJ
The Journal of cell biology 2019 Feb 4;218(2):644-663
The Journal of cell biology 2019 Feb 4;218(2):644-663
Quantitative proteomics screen identifies a substrate repertoire of rhomboid protease RHBDL2 in human cells and implicates it in epithelial homeostasis.
Johnson N, Březinová J, Stephens E, Burbridge E, Freeman M, Adrain C, Strisovsky K
Scientific reports 2017 Aug 4;7(1):7283
Scientific reports 2017 Aug 4;7(1):7283
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The RHBDL2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human RHBDL2. This antibody recognizes human, mouse, rat antigen. The RHBDL2 antibody has been validated for the following applications: ELISA, WB analysis.
