55309-1-AP

antibody from Proteintech Group

Targeting: MAT2A MATA2, MATII, SAMS2

Provider product page for 55309-1-AP

Western blot

ELISA

Immunoprecipitation

Antibody data

Antibody Data
Antigen structure
References [26]
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Validations
Western blot [1]

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Product number: 55309-1-AP - Provider product page
Provider: Proteintech Group
Product name: MAT2A antibody
Antibody type: Polyclonal
Description: MAT2A antibody (Cat. #55309-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IP, WB,ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

MAT2A protein structure - 55309-1-AP shown in red.

Submitted references MYCT1-IFITM2/3 interaction links endothelial endolysosomal trafficking to white adipose tissue expansion.

Wetterwald L, Köck A, Wyss T, Arroz-Madeira S, Prat-Luri B, Jaquet M, Petit B, Vozenin MC, Ylä-Herttuala S, Dutoit V, Migliorini D, Schaeuble K, Brisken C, Delorenzi M, Sabine A, Petrova TV
The Journal of experimental medicine 2026 May 4;223(5)

Silencing of MAT2A inhibits gastric cancer cell proliferation, migration, and invasion through activation of the p53 pathway.

Du Y, Li KX, You LB, Zhang JN, Chen Q, Xiong H, Wang JF, Zhou ZY, Zhang S
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2026 Jun;28(6):2183-2197

Activation of USP30 Disrupts Endothelial Cell Function and Aggravates Acute Lung Injury Through Regulating the S-Adenosylmethionine Cycle.

Baoyinna B, He J, Miao J, Shaheen N, Xia B, Wang C, Ma Q, Bernier MC, Whitson BA, Sun N, Zhao J, Zhao Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(2):e12807

A novel role of exostosin glycosyltransferase 2 (EXT2) in glioblastoma cell metabolism, radiosensitivity and ferroptosis.

Matesanz-Sánchez R, Peitzsch M, Lange I, Mircetic J, Seifert M, Cordes N, Vehlow A
Cell death and differentiation 2025 Sep;32(9):1664-1678

IGF2BP3 redirects glycolytic flux to promote one-carbon metabolism and RNA methylation.

Sharma G, Gutierrez M, Jones AE, Kapoor S, Jaiswal AK, Neeb ZT, Rios A, Dorairaj P, Thaxton ML, Lin TL, Tran TM, Kabbani LES, Ritter AJ, Scherer GM, Sorrentino JP, Stiles L, Hoeve JT, Damoiseaux RD, Garg NK, Divakaruni AS, Sanford JR, Rao DS
Cell reports 2025 Oct 28;44(10):116330

RBM15-mediated the m6A modification of MAT2A promotes osteosarcoma cell proliferation, metastasis and suppresses ferroptosis.

Huang Z, Chen P, Liu Y
Molecular and cellular biochemistry 2025 May;480(5):2923-2933

An RNA transmethylation pathway governs kidney nephrogenic potential.

Ramalingam H, Alvarez J, Flaten A, Cobo-Stark P, Foster N, Grilli E, Lakhia R, Aboudehen K, Carroll T, Patel V
Nature communications 2025 May 28;16(1):4930

MAT2A Knockdown Enhances Recombinant Protein Expression in Transgenic CHO Cells Through Regulation of Cell Cycle.

Gao YP, Lu JT, Zhang HJ, Cui ZM, Guo Y, Zhang X, Wang W, Qiu LL, Wang XY, Wang TY, Jia YL
Biotechnology and bioengineering 2025 Jun;122(6):1461-1471

SSB cooperates with METTL16-mediated m(6)A RNA methylation to promote chemoresistance in colorectal cancer cells.

Li H, Wilkinson E, Cui YH, Sun M, Lu K, Yang S, Bissonnette M, He YY
Cell reports 2025 Jul 22;44(7):115926

SARS-CoV-2 and HCoV-OC43 regulate host m6A modification via activation of the mTORC1 signalling pathway to facilitate viral replication.

Zhou S, Hui X, Wang W, Zhao C, Jin M, Qin Y, Chen M
Emerging microbes & infections 2025 Dec;14(1):2447620

MAT2A inhibition suppresses inflammation in Porphyromonas gingivalis-infected human gingival fibroblasts.

Jiang L, Li J, Ji K, Lei L, Li H
Journal of oral microbiology 2024;16(1):2292375

The role of forkhead box M1-methionine adenosyltransferase 2 A/2B axis in liver inflammation and fibrosis.

Yang B, Lu L, Xiong T, Fan W, Wang J, Barbier-Torres L, Chhimwal J, Sinha S, Tsuchiya T, Mavila N, Tomasi ML, Cao D, Zhang J, Peng H, Mato JM, Liu T, Yang X, Kalinichenko VV, Ramani K, Han J, Seki E, Yang H, Lu SC
Nature communications 2024 Sep 27;15(1):8388

Inhibition of MAT2A Impairs Skeletal Muscle Repair Function.

Xiao W, Huang TE, Zhou J, Wang B, Wang X, Zeng W, Wang Q, Lan X, Xiang Y
Biomolecules 2024 Sep 2;14(9)

Antibiotic-Induced Gut Microbiota Dysbiosis Modulates Host Transcriptome and m(6)A Epitranscriptome via Bile Acid Metabolism.

Yang M, Zheng X, Fan J, Cheng W, Yan TM, Lai Y, Zhang N, Lu Y, Qi J, Huo Z, Xu Z, Huang J, Jiao Y, Liu B, Pang R, Zhong X, Huang S, Luo GZ, Lee G, Jobin C, Eren AM, Chang EB, Wei H, Pan T, Wang X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jul;11(28):e2307981

Identification of a Sonically Activated Degrader of Methionine Adenosyltransferase 2A by an in Silico Approach Assisted with the Hole-Electron Analysis.

He H, Wang Z, Peng X, Qing L, Zhang Y, Fu S, Xu J, Li Y, Zhang S
Journal of medicinal chemistry 2024 Jan 11;67(1):543-554

PRMT1 orchestrates with SAMTOR to govern mTORC1 methionine sensing via Arg-methylation of NPRL2.

Jiang C, Liu J, He S, Xu W, Huang R, Pan W, Li X, Dai X, Guo J, Zhang T, Inuzuka H, Wang P, Asara JM, Xiao J, Wei W
Cell metabolism 2023 Dec 5;35(12):2183-2199.e7

Methionine orchestrates the metabolism vulnerability in cisplatin resistant bladder cancer microenvironment.

Yang C, Ou Y, Zhou Q, Liang Y, Li W, Chen Y, Chen W, Wu S, Chen Y, Dai X, Chen X, Chen T, Jin S, Liu Y, Zhang L, Liu S, Hu Y, Zou L, Mao S, Jiang H
Cell death & disease 2023 Aug 15;14(8):525

Oxidative Stress Aggravates Apoptosis of Nucleus Pulposus Cells through m(6)A Modification of MAT2A Pre-mRNA by METTL16.

Chen PB, Shi GX, Liu T, Li B, Jiang SD, Zheng XF, Jiang LS
Oxidative medicine and cellular longevity 2022;2022:4036274

Methionine metabolism controls the B cell EBV epigenome and viral latency.

Guo R, Liang JH, Zhang Y, Lutchenkov M, Li Z, Wang Y, Trujillo-Alonso V, Puri R, Giulino-Roth L, Gewurz BE
Cell metabolism 2022 Sep 6;34(9):1280-1297.e9

M(6)A RNA Methylation Mediates NOD1/NF-kB Signaling Activation in the Liver of Piglets Challenged with Lipopolysaccharide.

Xu M, Zhuo R, Tao S, Liang Y, Liu C, Liu Q, Wang T, Zhong X
Antioxidants (Basel, Switzerland) 2022 Sep 30;11(10)

Time-restricted feeding mitigates obesity through adipocyte thermogenesis.

Hepler C, Weidemann BJ, Waldeck NJ, Marcheva B, Cedernaes J, Thorne AK, Kobayashi Y, Nozawa R, Newman MV, Gao P, Shao M, Ramsey KM, Gupta RK, Bass J
Science (New York, N.Y.) 2022 Oct 21;378(6617):276-284

Inhibition of MAT2A suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss.

Kang H, Guo Q, Dong Y, Peng R, Song K, Wang J, Liu H, Zhu M, Zhao H, Guan H, Li F
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Feb;36(2):e22167

mTORC1 stimulates cell growth through SAM synthesis and m(6)A mRNA-dependent control of protein synthesis.

Villa E, Sahu U, O'Hara BP, Ali ES, Helmin KA, Asara JM, Gao P, Singer BD, Ben-Sahra I
Molecular cell 2021 May 20;81(10):2076-2093.e9

Activating transcription factor 4 regulates angiogenesis under lipid overload via methionine adenosyltransferase 2A-mediated endothelial epigenetic alteration.

Chen L, Liu X, Zhou H, Li G, Huang F, Zhang J, Xia T, Lei W, Zhao J, Li C, Chen M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Jun;35(6):e21612

The SESAME complex regulates cell senescence through the generation of acetyl-CoA.

Chen W, Yu X, Wu Y, Tang J, Yu Q, Lv X, Zha Z, Hu B, Li X, Chen J, Ma L, Workman JL, Li S
Nature metabolism 2021 Jul;3(7):983-1000

Ligustrazine modulates renal cysteine biosynthesis in rats exposed to cadmium.

Kuang W, Zhang X, Zhu W, Lan Z
Environmental toxicology and pharmacology 2017 Sep;54:125-132

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The MAT2A antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human MAT2A. This antibody recognizes human, mouse antigen. The MAT2A antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 55309-1-AP.pdf

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