19965-1-AP

antibody from Proteintech Group

Targeting: KCNJ2 IRK1, Kir2.1, LQT7

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

19965-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#19965-1-AP, RRID:AB_10859827

Product name

Kir2.1 antibody

Antibody type

Polyclonal

Description

Kir2.1 antibody (Cat. #19965-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

KCNJ4 variants disrupt inward-rectifier potassium channel function and cause refractory epilepsy.

Pan H, Liu D, Xu W, Li Y, Hu J, Henry O, Fuchs A, Jamra RA, Liu Z, He M, Chen Y, Wu S, Dong X, Chen Y, Wang P, Gu W, Jing H, Tang Y, Wang YJ, Mao X, Xiao N
Epilepsia 2026 Mar 14;

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Divaroside alleviates barium chloride-induced arrhythmia by activating the Nrf2/HO-1 axis to modulate autophagy and calcium homeostasis.

Zhang C, Huang S, Zhang W, Teng H, Shao Y, Zhang Y, Ren S, Wu Q, Zhao Y, Yan Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158149

---

TENS alleviates CP/CPPS-related inflammation and pain by modulating Kir2.1-dependent macrophage polarization.

Hong T, Liu X, Chi Z, Liu G, Zhang Y, Lin X, Yao P, Gong Q, Zhang Y, Hong X
Frontiers in immunology 2025;16:1683500

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NMDA-Type Glutamate Receptor Activation Promotes Ischemic Arrhythmias by Targeting the AKT1-TBX3-Nav1.5 Axis.

He Y, Zhang H, Zhang Q, Sun Z, Sun X, Xia L, Zheng L, Wang L
Acta physiologica (Oxford, England) 2025 Sep;241(9):e70085

---

m(6)A reader YTHDF2 governs the onset of atrial fibrillation by modulating Cacna1c translation.

Chen C, Wang G, Zou Q, Xiong K, Chen Z, Shao B, Liu Y, Xie D, Ji Y
Science China. Life sciences 2025 Mar;68(3):706-721

---

(124)I-labelled BMSC-Derived Extracellular Vesicles Deliver CRISPR/Cas9 Ribonucleoproteins With a GFP-Reporter System to Inhibit Osteosarcoma Proliferation and Metastasis.

Pan Y, Yang X, Zeng Z, Liu F, Luo J, Shen M, Zhou W, Li J, Jiang G, Sun L, Huang H, Pan R
Journal of extracellular vesicles 2025 Jul;14(7):e70130

---

Empagliflozin Ameliorates Atrial and Ventricular Remodeling and Arrhythmogenesis in an Overweight Rabbit Model.

Cheng WH, Lo LW, Chou YH, Liu SH, Lin WL, Chen SA
Acta Cardiologica Sinica 2024 Nov;40(6):729-739

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Administration of USP7 inhibitor p22077 alleviates Angiotensin II (Ang II)-induced atrial fibrillation in Mice.

Wang Y, Gu YH, Ren KW, Xie X, Wang SH, Zhu XX, Wang L, Yang XL, Bi HL
Hypertension research : official journal of the Japanese Society of Hypertension 2024 May;47(5):1309-1322

---

Knockdown of circZMIZ1 enhances the anti-tumor activity of CD8(+) T cells to alleviate hepatocellular carcinoma.

Li X, Wu A, Wang Y, Li D, Wu M
Functional & integrative genomics 2024 Feb 9;24(1):27

---

Salidroside treatment decreases the susceptibility of atrial fibrillation in diabetic mice by reducing mTOR-STAT3-MCP-1 signaling and atrial inflammation.

Ren W, Huang Y, Meng S, Cao Z, Qin N, Zhao J, Huang T, Guo X, Chen X, Zhou Z, Zhu Y, Yu L, Wang H
International immunopharmacology 2024 Dec 5;142(Pt B):113196

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KCNJ2/HIF1α positive-feedback loop promotes the metastasis of osteosarcoma.

Shen M, Pan R, Lei S, Zhang L, Zhou C, Zeng Z, Nie Y, Tian X
Cell communication and signaling : CCS 2023 Mar 2;21(1):46

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Overexpression of KCNJ2 enhances maturation of human-induced pluripotent stem cell-derived cardiomyocytes.

Zhou J, Cui B, Wang X, Wang H, Zheng J, Guo F, Sun Y, Fan H, Shen J, Su J, Wang J, Zhao H, Tang Y, Gong T, Sun N, Liang P
Stem cell research & therapy 2023 Apr 15;14(1):92

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Kir2.1-mediated membrane potential promotes nutrient acquisition and inflammation through regulation of nutrient transporters.

Yu W, Wang Z, Yu X, Zhao Y, Xie Z, Zhang K, Chi Z, Chen S, Xu T, Jiang D, Guo X, Li M, Zhang J, Fang H, Yang D, Guo Y, Yang X, Zhang X, Wu Y, Yang W, Wang D
Nature communications 2022 Jun 21;13(1):3544

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Kir2.1 channel regulates macrophage polarization via the Ca2+/CaMK II/ERK/NF-κB signaling pathway.

Chen K, Man Q, Miao J, Xu W, Zheng Y, Zhou X, Gao Z
Journal of cell science 2022 Jul 1;135(13)

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Long noncoding RNA TCONS-00106987 promotes atrial electrical remodelling during atrial fibrillation by sponging miR-26 to regulate KCNJ2.

Du J, Li Z, Wang X, Li J, Liu D, Wang X, Wei J, Ma S, Zhang Y, Hou Y
Journal of cellular and molecular medicine 2020 Nov;24(21):12777-12788

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Nucleoporin 107 facilitates the nuclear export of Scn5a mRNA to regulate cardiac bioelectricity.

Guan Y, Gao X, Tang Q, Huang L, Gao S, Yu S, Huang J, Li J, Zhou D, Zhang Y, Shi D, Liang D, Liu Y, Li L, Cui Y, Xu L, Chen YH
Journal of cellular and molecular medicine 2019 Feb;23(2):1448-1457

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Altered long non-coding RNA expression profile in rabbit atria with atrial fibrillation: TCONS_00075467 modulates atrial electrical remodeling by sponging miR-328 to regulate CACNA1C.

Li Z, Wang X, Wang W, Du J, Wei J, Zhang Y, Wang J, Hou Y
Journal of molecular and cellular cardiology 2017 Jul;108:73-85

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

A549 cells were subjected to SDS PAGE followed by western blot with 19965-1-AP(KCNJ2 antibody) at dilution of 1:200

Sample type

cell line

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

The Kir2.1 antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human Kir2.1. This antibody recognizes human,mouse,rat antigen. The Kir2.1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.

Appendix

19965-1-AP.pdf

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