Antibody data
- Antibody Data
- Antigen structure
- References [22]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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Validation data
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- Product number
- 11110-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11110-1-AP, RRID:AB_10915966
- Product name
- CYLD antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated CYLD antibody (Cat. #11110-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references The miR-19a/Cylindromatosis Axis Regulates Pituitary Adenoma Bone Invasion by Promoting Osteoclast Differentiation.
Neural mechanism underlies CYLD modulation of morphology and synaptic function of medium spiny neurons in dorsolateral striatum.
Centrosomal protein 120 promotes centrosome amplification and gastric cancer progression via USP54-mediated deubiquitination of PLK4.
CYLD deficiency enhances metabolic reprogramming and tumor progression in nasopharyngeal carcinoma via PFKFB3.
Downregulation of m(6)A Reader YTHDC2 Promotes the Proliferation and Migration of Malignant Lung Cells via CYLD/NF-κB Pathway.
Spata2 Knockdown Exacerbates Brain Inflammation via NF-κB/P38MAPK Signaling and NLRP3 Inflammasome Activation in Cerebral Ischemia/Reperfusion Rats.
TRIM15 and CYLD regulate ERK activation via lysine-63-linked polyubiquitination.
Exosomal microRNA-588 from M2 polarized macrophages contributes to cisplatin resistance of gastric cancer cells.
USP15 participates in DBP-induced testicular oxidative stress injury through regulating the Keap1/Nrf2 signaling pathway.
CYLD Promotes Apoptosis of Nasopharyngeal Carcinoma Cells by Regulating NDRG1.
MiR-362-5p, Which Is Regulated by Long Non-Coding RNA MBNL1-AS1, Promotes the Cell Proliferation and Tumor Growth of Bladder Cancer by Targeting QKI.
The long noncoding RNA CRAL reverses cisplatin resistance via the miR-505/CYLD/AKT axis in human gastric cancer cells.
Liraglutide Lowers Body Weight Set Point in DIO Rats and its Relationship with Hypothalamic Microglia Activation.
Maternal folic acid depletion during early pregnancy increases sensitivity to squamous tumor formation in the offspring in mice.
MicroRNA-301b promotes cell proliferation and apoptosis resistance in triple-negative breast cancer by targeting CYLD.
miR-501 is upregulated in cervical cancer and promotes cell proliferation, migration and invasion by targeting CYLD.
Electroacupuncture Suppresses the NF-κB Signaling Pathway by Upregulating Cylindromatosis to Alleviate Inflammatory Injury in Cerebral Ischemia/Reperfusion Rats.
CYLD Deubiquitinates Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 Contributing to Adventitial Remodeling.
CYLD Promotes TNF-α-Induced Cell Necrosis Mediated by RIP-1 in Human Lung Cancer Cells.
Downregulation of miR-362-5p inhibits proliferation, migration and invasion of human breast cancer MCF7 cells.
MicroRNA-362-5p promotes tumor growth and metastasis by targeting CYLD in hepatocellular carcinoma.
Down-regulation of miR-181b promotes apoptosis by targeting CYLD in thyroid papillary cancer.
Lei Z, Wang Q, Jiang Q, Liu H, Xu L, Kang H, Li F, Huang Y, Lei T
Cancers 2024 Jan 11;16(2)
Cancers 2024 Jan 11;16(2)
Neural mechanism underlies CYLD modulation of morphology and synaptic function of medium spiny neurons in dorsolateral striatum.
Tan SY, Jiang JX, Huang HX, Mo XP, Feng JR, Chen Y, Yang L, Long C
Frontiers in molecular neuroscience 2023;16:1107355
Frontiers in molecular neuroscience 2023;16:1107355
Centrosomal protein 120 promotes centrosome amplification and gastric cancer progression via USP54-mediated deubiquitination of PLK4.
Zhang C, Ma X, Wei G, Zhu X, Hu P, Chen X, Wang D, Li Y, Ruan T, Zhang W, Tao K, Wu C
iScience 2023 Jan 20;26(1):105745
iScience 2023 Jan 20;26(1):105745
CYLD deficiency enhances metabolic reprogramming and tumor progression in nasopharyngeal carcinoma via PFKFB3.
Wang L, Lin Y, Zhou X, Chen Y, Li X, Luo W, Zhou Y, Cai L
Cancer letters 2022 Apr 28;532:215586
Cancer letters 2022 Apr 28;532:215586
Downregulation of m(6)A Reader YTHDC2 Promotes the Proliferation and Migration of Malignant Lung Cells via CYLD/NF-κB Pathway.
Wang J, Tan L, Jia B, Yu X, Yao R, OUYang N, Yu X, Cao X, Tong J, Chen T, Chen R, Li J
International journal of biological sciences 2021;17(10):2633-2651
International journal of biological sciences 2021;17(10):2633-2651
Spata2 Knockdown Exacerbates Brain Inflammation via NF-κB/P38MAPK Signaling and NLRP3 Inflammasome Activation in Cerebral Ischemia/Reperfusion Rats.
Ren Y, Jiang J, Jiang W, Zhou X, Lu W, Wang J, Luo Y
Neurochemical research 2021 Sep;46(9):2262-2275
Neurochemical research 2021 Sep;46(9):2262-2275
TRIM15 and CYLD regulate ERK activation via lysine-63-linked polyubiquitination.
Zhu G, Herlyn M, Yang X
Nature cell biology 2021 Sep;23(9):978-991
Nature cell biology 2021 Sep;23(9):978-991
Exosomal microRNA-588 from M2 polarized macrophages contributes to cisplatin resistance of gastric cancer cells.
Cui HY, Rong JS, Chen J, Guo J, Zhu JQ, Ruan M, Zuo RR, Zhang SS, Qi JM, Zhang BH
World journal of gastroenterology 2021 Sep 28;27(36):6079-6092
World journal of gastroenterology 2021 Sep 28;27(36):6079-6092
USP15 participates in DBP-induced testicular oxidative stress injury through regulating the Keap1/Nrf2 signaling pathway.
Zhang L, Gao X, Qin Z, Shi X, Xu K, Wang S, Tang M, Wang W, Gao S, Zuo L, Zhang L, Zhang W
The Science of the total environment 2021 Aug 20;783:146898
The Science of the total environment 2021 Aug 20;783:146898
CYLD Promotes Apoptosis of Nasopharyngeal Carcinoma Cells by Regulating NDRG1.
Lin Y, Wang L, Luo W, Zhou X, Chen Y, Yang K, Liao J, Wu D, Cai L
Cancer management and research 2020;12:10639-10649
Cancer management and research 2020;12:10639-10649
MiR-362-5p, Which Is Regulated by Long Non-Coding RNA MBNL1-AS1, Promotes the Cell Proliferation and Tumor Growth of Bladder Cancer by Targeting QKI.
Wei X, Wang B, Wang Q, Yang X, Yang Y, Fang Z, Yi C, Shi L, Fan X, Tao J, Guo Y, Song D
Frontiers in pharmacology 2020;11:164
Frontiers in pharmacology 2020;11:164
The long noncoding RNA CRAL reverses cisplatin resistance via the miR-505/CYLD/AKT axis in human gastric cancer cells.
Wang Z, Wang Q, Xu G, Meng N, Huang X, Jiang Z, Chen C, Zhang Y, Chen J, Li A, Li N, Zou X, Zhou J, Ding Q, Wang S
RNA biology 2020 Nov;17(11):1576-1589
RNA biology 2020 Nov;17(11):1576-1589
Liraglutide Lowers Body Weight Set Point in DIO Rats and its Relationship with Hypothalamic Microglia Activation.
Liao T, Zhang SL, Yuan X, Mo WQ, Wei F, Zhao SN, Yang W, Liu H, Rong X
Obesity (Silver Spring, Md.) 2020 Jan;28(1):122-131
Obesity (Silver Spring, Md.) 2020 Jan;28(1):122-131
Maternal folic acid depletion during early pregnancy increases sensitivity to squamous tumor formation in the offspring in mice.
Kawakubo-Yasukochi T, Morioka M, Ohe K, Yasukochi A, Ozaki Y, Hazekawa M, Nishinakagawa T, Ono K, Nakamura S, Nakashima M
Journal of developmental origins of health and disease 2019 Dec;10(6):683-691
Journal of developmental origins of health and disease 2019 Dec;10(6):683-691
MicroRNA-301b promotes cell proliferation and apoptosis resistance in triple-negative breast cancer by targeting CYLD.
Song H, Li D, Wu T, Xie D, Hua K, Hu J, Deng X, Ji C, Deng Y, Fang L
BMB reports 2018 Nov;51(11):602-607
BMB reports 2018 Nov;51(11):602-607
miR-501 is upregulated in cervical cancer and promotes cell proliferation, migration and invasion by targeting CYLD.
Sanches JGP, Xu Y, Yabasin IB, Li M, Lu Y, Xiu X, Wang L, Mao L, Shen J, Wang B, Hou L, Ju J, Zhao J, Song B
Chemico-biological interactions 2018 Apr 1;285:85-95
Chemico-biological interactions 2018 Apr 1;285:85-95
Electroacupuncture Suppresses the NF-κB Signaling Pathway by Upregulating Cylindromatosis to Alleviate Inflammatory Injury in Cerebral Ischemia/Reperfusion Rats.
Jiang J, Luo Y, Qin W, Ma H, Li Q, Zhan J, Zhang Y
Frontiers in molecular neuroscience 2017;10:363
Frontiers in molecular neuroscience 2017;10:363
CYLD Deubiquitinates Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 Contributing to Adventitial Remodeling.
Yu B, Liu Z, Fu Y, Wang Y, Zhang L, Cai Z, Yu F, Wang X, Zhou J, Kong W
Arteriosclerosis, thrombosis, and vascular biology 2017 Sep;37(9):1698-1709
Arteriosclerosis, thrombosis, and vascular biology 2017 Sep;37(9):1698-1709
CYLD Promotes TNF-α-Induced Cell Necrosis Mediated by RIP-1 in Human Lung Cancer Cells.
Lin X, Chen Q, Huang C, Xu X
Mediators of inflammation 2016;2016:1542786
Mediators of inflammation 2016;2016:1542786
Downregulation of miR-362-5p inhibits proliferation, migration and invasion of human breast cancer MCF7 cells.
Ni F, Gui Z, Guo Q, Hu Z, Wang X, Chen D, Wang S
Oncology letters 2016 Feb;11(2):1155-1160
Oncology letters 2016 Feb;11(2):1155-1160
MicroRNA-362-5p promotes tumor growth and metastasis by targeting CYLD in hepatocellular carcinoma.
Ni F, Zhao H, Cui H, Wu Z, Chen L, Hu Z, Guo C, Liu Y, Chen Z, Wang X, Chen D, Wei H, Wang S
Cancer letters 2015 Jan 28;356(2 Pt B):809-18
Cancer letters 2015 Jan 28;356(2 Pt B):809-18
Down-regulation of miR-181b promotes apoptosis by targeting CYLD in thyroid papillary cancer.
Li D, Jian W, Wei C, Song H, Gu Y, Luo Y, Fang L
International journal of clinical and experimental pathology 2014;7(11):7672-80
International journal of clinical and experimental pathology 2014;7(11):7672-80
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- A431 cells were subjected to SDS PAGE followed by western blot with 11110-1-AP(CYLD antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The CYLD antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human CYLD. This antibody recognizes human, mouse, rat antigen. The CYLD antibody has been validated for the following applications: ELISA, WB, IHC analysis.