ABIN351200

antibody from antibodies-online

Targeting: TRPM4 FLJ20041

Western blot (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

ABIN351200

Provider

antibodies-online

Proper citation

Antibodies-Online Cat#ABIN351200, RRID:AB_10785828

Product name

anti-Transient Receptor Potential Cation Channel, Subfamily M, Member 4 (TRPM4) (C-Term) antibody

Antibody type

Polyclonal

Antigen

A synthetic peptide from c-terminal region of human transient receptor potential cation channel subfamily M member 4 (TRPM4, melastatin-4) conjugated to an immunogenic carrier protein was used as the antigen.

Reactivity

Human

Host

Sheep

Epitope

C-Term

Vial size

150 μL

Storage

Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability.

Handling

Avoid freeze and thaw cycles.

References

Submitted references

TRPM4 controls insulin secretion in pancreatic beta-cells.

Cheng H, Beck A, Launay P, Gross SA, Stokes AJ, Kinet JP, Fleig A, Penner R
Cell calcium 2007 Jan;41(1):51-61

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A pyrazole derivative potently inhibits lymphocyte Ca2+ influx and cytokine production by facilitating transient receptor potential melastatin 4 channel activity.

Takezawa R, Cheng H, Beck A, Ishikawa J, Launay P, Kubota H, Kinet JP, Fleig A, Yamada T, Penner R
Molecular pharmacology 2006 Apr;69(4):1413-20

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Phosphatidylinositol 4,5-bisphosphate rescues TRPM4 channels from desensitization.

Zhang Z, Okawa H, Wang Y, Liman ER
The Journal of biological chemistry 2005 Nov 25;280(47):39185-92

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The selectivity filter of the cation channel TRPM4.

Nilius B, Prenen J, Janssens A, Owsianik G, Wang C, Zhu MX, Voets T
The Journal of biological chemistry 2005 Jun 17;280(24):22899-906

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Critical role for transient receptor potential channel TRPM4 in myogenic constriction of cerebral arteries.

Earley S, Waldron BJ, Brayden JE
Circulation research 2004 Oct 29;95(9):922-9

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TRPM4 regulates calcium oscillations after T cell activation.

Launay P, Cheng H, Srivatsan S, Penner R, Fleig A, Kinet JP
Science (New York, N.Y.) 2004 Nov 19;306(5700):1374-7

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Complete sequencing and characterization of 21,243 full-length human cDNAs.

Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nature genetics 2004 Jan;36(1):40-5

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TRPM5 is a voltage-modulated and Ca(2+)-activated monovalent selective cation channel.

Hofmann T, Chubanov V, Gudermann T, Montell C
Current biology : CB 2003 Jul 1;13(13):1153-8

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TRPM4 is a Ca2+-activated nonselective cation channel mediating cell membrane depolarization.

Launay P, Fleig A, Perraud AL, Scharenberg AM, Penner R, Kinet JP
Cell 2002 May 3;109(3):397-407

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Regulation of melastatin, a TRP-related protein, through interaction with a cytoplasmic isoform.

Xu XZ, Moebius F, Gill DL, Montell C
Proceedings of the National Academy of Sciences of the United States of America 2001 Sep 11;98(19):10692-7