20787-1-AP

antibody from Proteintech Group

Targeting: SMO FZD11, SMOH

ELISA (Data presented on provider website)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

20787-1-AP

Provider

Proteintech Group

Product name

SMO antibody

Antibody type

Polyclonal

Description

SMO antibody (Cat. #20787-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC,ELISA.

Reactivity

Human, Mouse

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

RPL35 downregulated by mechanical overloading promotes chondrocyte senescence and osteoarthritis development via Hedgehog-Gli1 signaling.

Zhu J, Liu L, Lin R, Guo X, Yin J, Xie H, Lu Y, Zhang Z, Zhang H, Yao Z, Zhang H, Wang X, Zeng C, Cai D
Journal of orthopaedic translation 2024 Mar;45:226-235

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Alginate microspheres encapsulating hox transcript antisense RNA siRNA regulate the Hedgehog-Gli1 pathway to alleviate epidermal growth factor receptor tyrosine kinase inhibitors resistance.

Lu G, Zhong H, Gao J, Zhang Y
Journal of biomaterials applications 2024 Mar;38(8):877-889

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GIMAP7 inhibits epithelial-mesenchymal transition and glycolysis in lung adenocarcinoma cells via regulating the Smo/AMPK signaling pathway.

Cui L, Shen Y, Duan S, Ding Q, Wang Y, Yang W, Chen Y
Thoracic cancer 2024 Feb;15(4):286-298

---

Rgl-exomiR-7972, a novel plant exosomal microRNA derived from fresh Rehmanniae Radix, ameliorated lipopolysaccharide-induced acute lung injury and gut dysbiosis.

Qiu FS, Wang JF, Guo MY, Li XJ, Shi CY, Wu F, Zhang HH, Ying HZ, Yu CH
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Sep;165:115007

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Diallyl trisulfide inhibits gastric cancer stem cell properties through ΔNp63/sonic hedgehog pathway.

Ge M, Zhu J, Yi K, Chen Y, Cao W, Wang M, Xie C, Li X, Geng S, Wu J, Zhong C, Cao H, Jiang Z, Han H
Molecular carcinogenesis 2023 Nov;62(11):1673-1685

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N6-methyladenine-mediated aberrant activation of the lncRNA SOX2OT-GLI1 loop promotes non-small-cell lung cancer stemness.

Dong H, Zeng L, Chen W, Zhang Q, Wang F, Wu Y, Cui B, Qi J, Zhang X, Liu C, Deng J, Yu Y, Schmitt CA, Du J
Cell death discovery 2023 May 6;9(1):149

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Low-dose phthalates promote breast cancer stem cell properties via the oncogene ΔNp63α and the Sonic hedgehog pathway.

Cao WS, Zhao MJ, Chen Y, Zhu JY, Xie CF, Li XT, Geng SS, Zhong CY, Fu JY, Wu JS
Ecotoxicology and environmental safety 2023 Mar 1;252:114605

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MAML3 Contributes to Induction of Malignant Phenotype of Gallbladder Cancer Through Morphogenesis Signalling Under Hypoxia.

Na L, Onishi H, Morisaki S, Ichimiya S, Yamada Y, Masuda S, Nagao S, Koga S, Nakayama K, Imaizumi A, Oda Y, Nakamura M
Anticancer research 2023 Jul;43(7):2909-2922

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Hedgehog target genes regulate lipid metabolism to drive basal cell carcinoma and medulloblastoma.

Daggubati V, Vykunta A, Choudhury A, Qadeer Z, Mirchia K, Saulnier O, Zakimi N, Hines K, Paul M, Wang L, Jura N, Xu L, Reiter J, Taylor M, Weiss W, Raleigh D
Research square 2023 Aug 3;

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Involvement of hedgehog signaling in all-trans retinoic acid-mediated suppression of colon cancer.

Xu Y, Sun H
American journal of translational research 2022;14(9):6536-6549

---

The ciliary gene INPP5E confers dorsal telencephalic identity to human cortical organoids by negatively regulating Sonic hedgehog signaling.

Schembs L, Willems A, Hasenpusch-Theil K, Cooper JD, Whiting K, Burr K, Bøstrand SMK, Selvaraj BT, Chandran S, Theil T
Cell reports 2022 May 17;39(7):110811

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Angiomotin isoform 2 promotes binding of PALS1 to KIF13B at primary cilia and regulates ciliary length and signaling.

Morthorst SK, Nielsen C, Farinelli P, Anvarian Z, Rasmussen CBR, Serra-Marques A, Grigoriev I, Altelaar M, Fürstenberg N, Ludwig A, Akhmanova A, Christensen ST, Pedersen LB
Journal of cell science 2022 Jun 15;135(12)

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Cepharanthine hydrochloride inhibits the Wnt/β‑catenin/Hedgehog signaling axis in liver cancer.

Su GF, Huang ZX, Huang DL, Chen PX, Wang Y, Wang YF
Oncology reports 2022 Apr;47(4)

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BRD4 promotes the migration and invasion of bladder cancer cells through the Sonic hedgehog signaling pathway and enhances cisplatin resistance.

Liu T, Zhang Z, Wang C, Huang H, Li Y
Biochemistry and cell biology = Biochimie et biologie cellulaire 2022 Apr;100(2):179-187

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METTL3-mediated m6A modification of STEAP2 mRNA inhibits papillary thyroid cancer progress by blocking the Hedgehog signaling pathway and epithelial-to-mesenchymal transition.

Zhu Y, Peng X, Zhou Q, Tan L, Zhang C, Lin S, Long M
Cell death & disease 2022 Apr 18;13(4):358

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Apatinib Suppresses Gastric Cancer Stem Cells Properties by Inhibiting the Sonic Hedgehog Pathway.

Cao W, Li Y, Sun H, Yang C, Zhu J, Xie C, Li X, Wu J, Geng S, Wang L, Sun L, Geng G, Han H, Zhong C
Frontiers in cell and developmental biology 2021;9:679806

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Repurposing of posaconazole as a hedgehog/SMO signaling inhibitor for embryonal rhabdomyosarcoma therapy.

Sun J, Lin W, Li C, Ueki H, Xue R, Sadahira T, Hu H, Wada K, Li N, Liu C, Araki M, Xu A, Huang P
American journal of cancer research 2021;11(9):4528-4540

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Epigallocatechin-3-gallate inhibits proliferation and triggers apoptosis in colon cancer via the hedgehog/phosphoinositide 3-kinase pathways.

Ding F, Yang S
Canadian journal of physiology and pharmacology 2021 Sep;99(9):910-920

---

Activation of the Hedgehog and Wnt/β-Catenin Signaling Pathways in Basal Cell Carcinoma.

Takada T
Case reports in dermatology 2021 Sep-Dec;13(3):506-512

---

Circular RNA circIPO11 drives self-renewal of liver cancer initiating cells via Hedgehog signaling.

Gu Y, Wang Y, He L, Zhang J, Zhu X, Liu N, Wang J, Lu T, He L, Tian Y, Fan Z
Molecular cancer 2021 Oct 14;20(1):132

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GLI2 but not GLI1/GLI3 plays a central role in the induction of malignant phenotype of gallbladder cancer.

Ichimiya S, Onishi H, Nagao S, Koga S, Sakihama K, Nakayama K, Fujimura A, Oyama Y, Imaizumi A, Oda Y, Nakamura M
Oncology reports 2021 Mar;45(3):997-1010

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Differential effects of EPA and DHA on DSS-induced colitis in mice and possible mechanisms involved.

Zhang Z, Xue Z, Yang H, Zhao F, Liu C, Chen J, Lu S, Zou Z, Zhou Y, Zhang X
Food & function 2021 Mar 1;12(4):1803-1817

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Sterol and oxysterol synthases near the ciliary base activate the Hedgehog pathway.

Findakly S, Daggubati V, Garcia G, LaStella SA, Choudhury A, Tran C, Li A, Tong P, Garcia JQ, Puri N, Reiter JF, Xu L, Raleigh DR
The Journal of cell biology 2021 Jan 4;220(1)

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MicroRNA miR-19b-3p mediated G protein γ subunit 7 (GNG7) loss contributes lung adenocarcinoma progression through activating Hedgehog signaling.

Zhao X, Zhang XC, Zang K, Yu ZH
Bioengineered 2021 Dec;12(1):7849-7858

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Cigarette smoke supports stemness and epithelial-mesenchymal transition in bladder cancer stem cells through SHH signaling.

Sun X, Song J, Li E, Geng H, Li Y, Yu D, Zhong C
International journal of clinical and experimental pathology 2020;13(6):1333-1348

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Primary cilium remodeling mediates a cell signaling switch in differentiating neurons.

Toro-Tapia G, Das RM
Science advances 2020 May;6(21):eabb0601

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Meningioma cells express primary cilia but do not transduce ciliary Hedgehog signals.

Findakly S, Choudhury A, Daggubati V, Pekmezci M, Lang UE, Raleigh DR
Acta neuropathologica communications 2020 Jul 20;8(1):114

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Exosomal Sonic Hedgehog derived from cancer-associated fibroblasts promotes proliferation and migration of esophageal squamous cell carcinoma.

Zhao G, Li H, Guo Q, Zhou A, Wang X, Li P, Zhang S
Cancer medicine 2020 Apr;9(7):2500-2513

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Genistein inhibits nasopharyngeal cancer stem cells through sonic hedgehog signaling.

Zhang Q, Cao WS, Wang XQ, Zhang M, Lu XM, Chen JQ, Chen Y, Ge MM, Zhong CY, Han HY
Phytotherapy research : PTR 2019 Oct;33(10):2783-2791

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TSPAN8 promotes cancer cell stemness via activation of sonic Hedgehog signaling.

Zhu R, Gires O, Zhu L, Liu J, Li J, Yang H, Ju G, Huang J, Ge W, Chen Y, Lu Z, Wang H
Nature communications 2019 Jun 28;10(1):2863

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Sulforaphane inhibits gastric cancer stem cells via suppressing sonic hedgehog pathway.

Ge M, Zhang L, Cao L, Xie C, Li X, Li Y, Meng Y, Chen Y, Wang X, Chen J, Zhang Q, Shao J, Zhong C
International journal of food sciences and nutrition 2019 Aug;70(5):570-578

---

Effects of baicalein on pancreatic cancer stem cells via modulation of sonic Hedgehog pathway.

Song L, Chen X, Wang P, Gao S, Qu C, Liu L
Acta biochimica et biophysica Sinica 2018 Jun 1;50(6):586-596

---

Salinomycin suppresses cancer cell stemness and attenuates TGF-β-induced epithelial-mesenchymal transition of renal cell carcinoma cells.

Liu L, Wang Q, Mao J, Qin T, Sun Y, Yang J, Han Y, Li L, Li Q
Chemico-biological interactions 2018 Dec 25;296:145-153

---

Curcumin inhibits bladder cancer stem cells by suppressing Sonic Hedgehog pathway.

Wang D, Kong X, Li Y, Qian W, Ma J, Wang D, Yu D, Zhong C
Biochemical and biophysical research communications 2017 Nov 4;493(1):521-527

---

Curcumin Suppresses Lung Cancer Stem Cells via Inhibiting Wnt/β-catenin and Sonic Hedgehog Pathways.

Zhu JY, Yang X, Chen Y, Jiang Y, Wang SJ, Li Y, Wang XQ, Meng Y, Zhu MM, Ma X, Huang C, Wu R, Xie CF, Li XT, Geng SS, Wu JS, Zhong CY, Han HY
Phytotherapy research : PTR 2017 Apr;31(4):680-688

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

The SMO antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human SMO. This antibody recognizes human antigen. The SMO antibody has been validated for the following applications: ELISA, IHC analysis.

Appendix

20787-1-AP.pdf

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