20787-1-AP

antibody from Proteintech Group

Targeting: SMO FZD11, SMOH

Provider product page for 20787-1-AP

ELISA

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [50]
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Validations
Immunohistochemistry [1]

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Product number: 20787-1-AP - Provider product page
Provider: Proteintech Group
Product name: SMO antibody
Antibody type: Polyclonal
Description: SMO antibody (Cat. #20787-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC,ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

SMO protein structure - 20787-1-AP shown in red.

Submitted references HOXB4 Promotes Bladder Cancer Progression in Part Through Transcriptional Activation of Smoothened.

Jin Z, Yang W, Peng Y, Ma L, Li Z, Dong J, Ji Z
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Jan 15;40(1):e71388

siRASA1 in vascular endothelial cells alleviates subretinal fibrosis through inhibiting macrophage-myofibroblast transdifferentiation via SHH signaling pathway.

Jiang L, Xu Z, Ma J, Cai W, Lin R, Hu C, Luo Y, Liang F, Wu Y, Yu J
Cellular signalling 2026 Feb;138:112261

ALIX and ITCH localize to the base of primary cilia and negatively regulate ciliary Polycystin-2 levels.

Berggreen CR, Laplace J, Campestre F, Petersen AW, Fixdahl AM, Mary B, Ghazanfar S, Li G, Wagner LE, Rezi CK, Chamlali M, Anvarian Z, Christensen ST, May-Simera HL, Pedersen LB
BMC molecular and cell biology 2026 Feb 25;27(1)

Cyperotundone promotes chemosensitivity of breast cancer via SRSF1.

Li C, Wang L, Liu Z, Wang X, Sun L, Song X, Yu Z
Frontiers in pharmacology 2025;16:1510161

Primary cilia in growth plates orchestrate long bone development.

Zhang L, Xu X, Tao D, Li X, Niu P, Gong X, Li G, Yu M, Sun Y
Fundamental research 2025 Sep;5(5):2368-2381

High matrix stiffness triggers testosterone decline in aging males by disrupting stem Leydig cell pool homeostasis.

Huang J, Sun L, Yin Y, Yang H, Zeng K, Huang P, Liang X, Wu J, Xiang AP, Wang J
Cell reports 2025 Sep 23;44(9):116207

Buyang Huanwu Decoction enhances hippocampal-cortical connectivity remodeling via sonic hedgehog signaling to ameliorate memory dysfunction in cerebral ischemic rats.

Lu Y, Lin Z, Wang H, Zhuang Y, Jia J, Wang Y, Yang L, Li M, Li M, Nie B, Zhang R, Pan X, Lei J, Zou H, Zhao H
Chinese medicine 2025 Sep 19;20(1):144

Smpd3 regulates odontoblast differentiation through the Shh-Gli1 pathway.

Chu CH, Wang J, Zhang C, Li G, Wang L
Bone 2025 Nov;200:117587

A conserved mechanism for the retrieval of polyubiquitinated proteins from cilia.

Lange SM, Bennett JA, Eisert RJ, Brown A
Cell 2025 Nov 13;188(23):6492-6508.e18

NaHS@Cy5@MS@SP nanoparticles improve rheumatoid arthritis by inactivating the Hedgehog signaling pathway through sustained and targeted release of H(2)S into the synovium.

Zhu XX, Xu AJ, Cai WW, Han ZJ, Zhang SJ, Hou B, Wen YY, Cao XY, Li HD, Du YQ, Zhuang YY, Wang J, Hu XR, Bai XR, Su JB, Zhang AY, Lu QB, Gu Y, Qiu LY, Pan L, Sun HJ
Journal of nanobiotechnology 2025 Mar 8;23(1):192

The highly expressed GOLPH3 in colorectal cancer cells activates smoothened to drive glycolysis and promote cancer cell growth and radiotherapy resistance.

Zhu K, Fan J, Cai H, Zhou C, Gong Z, Li Z, Yu J
Journal of gastrointestinal oncology 2025 Apr 30;16(2):415-434

The H2Valdien derivatives regulate the epithelial-mesenchymal transition of hepatoma carcinoma cells through the Hedgehog signaling pathway.

Zhao X, Shao X, Huang X, Dang C, Wang R, Li H
Open medicine (Warsaw, Poland) 2024;19(1):20240954

Hedgehog signaling pathway regulates Th17 cell differentiation in asthma via IL-6/STAT3 signaling.

Jin Y, Pan Z, Zhou J, Wang K, Zhu P, Wang Y, Xu X, Zhang J, Hao C
International immunopharmacology 2024 Sep 30;139:112771

IHH-GLI-1-HIF-2α signalling influences hypertrophic chondrocytes to exacerbate osteoarthritis progression.

Zhang C, Zhao R, Dong Z, Liu Y, Liu M, Li H, Yin Y, Che X, Wu G, Li Guo, Li P, Wei X, Yang Z
Journal of orthopaedic translation 2024 Nov;49:207-217

RPL35 downregulated by mechanical overloading promotes chondrocyte senescence and osteoarthritis development via Hedgehog-Gli1 signaling.

Zhu J, Liu L, Lin R, Guo X, Yin J, Xie H, Lu Y, Zhang Z, Zhang H, Yao Z, Zhang H, Wang X, Zeng C, Cai D
Journal of orthopaedic translation 2024 Mar;45:226-235

Alginate microspheres encapsulating hox transcript antisense RNA siRNA regulate the Hedgehog-Gli1 pathway to alleviate epidermal growth factor receptor tyrosine kinase inhibitors resistance.

Lu G, Zhong H, Gao J, Zhang Y
Journal of biomaterials applications 2024 Mar;38(8):877-889

GIMAP7 inhibits epithelial-mesenchymal transition and glycolysis in lung adenocarcinoma cells via regulating the Smo/AMPK signaling pathway.

Cui L, Shen Y, Duan S, Ding Q, Wang Y, Yang W, Chen Y
Thoracic cancer 2024 Feb;15(4):286-298

GFRA4 improves the neurogenic potential of enteric neural crest stem cells via hedgehog pathway.

Zhang F, Cui M, Zhang L, Ma B, Guo F, Wang G
Pediatric research 2024 Apr 24;

Rgl-exomiR-7972, a novel plant exosomal microRNA derived from fresh Rehmanniae Radix, ameliorated lipopolysaccharide-induced acute lung injury and gut dysbiosis.

Qiu FS, Wang JF, Guo MY, Li XJ, Shi CY, Wu F, Zhang HH, Ying HZ, Yu CH
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Sep;165:115007

Diallyl trisulfide inhibits gastric cancer stem cell properties through ΔNp63/sonic hedgehog pathway.

Ge M, Zhu J, Yi K, Chen Y, Cao W, Wang M, Xie C, Li X, Geng S, Wu J, Zhong C, Cao H, Jiang Z, Han H
Molecular carcinogenesis 2023 Nov;62(11):1673-1685

N6-methyladenine-mediated aberrant activation of the lncRNA SOX2OT-GLI1 loop promotes non-small-cell lung cancer stemness.

Dong H, Zeng L, Chen W, Zhang Q, Wang F, Wu Y, Cui B, Qi J, Zhang X, Liu C, Deng J, Yu Y, Schmitt CA, Du J
Cell death discovery 2023 May 6;9(1):149

Low-dose phthalates promote breast cancer stem cell properties via the oncogene ΔNp63α and the Sonic hedgehog pathway.

Cao WS, Zhao MJ, Chen Y, Zhu JY, Xie CF, Li XT, Geng SS, Zhong CY, Fu JY, Wu JS
Ecotoxicology and environmental safety 2023 Mar 1;252:114605

MAML3 Contributes to Induction of Malignant Phenotype of Gallbladder Cancer Through Morphogenesis Signalling Under Hypoxia.

Na L, Onishi H, Morisaki S, Ichimiya S, Yamada Y, Masuda S, Nagao S, Koga S, Nakayama K, Imaizumi A, Oda Y, Nakamura M
Anticancer research 2023 Jul;43(7):2909-2922

Hedgehog target genes regulate lipid metabolism to drive basal cell carcinoma and medulloblastoma.

Daggubati V, Vykunta A, Choudhury A, Qadeer Z, Mirchia K, Saulnier O, Zakimi N, Hines K, Paul M, Wang L, Jura N, Xu L, Reiter J, Taylor M, Weiss W, Raleigh D
Research square 2023 Aug 3;

Involvement of hedgehog signaling in all-trans retinoic acid-mediated suppression of colon cancer.

Xu Y, Sun H
American journal of translational research 2022;14(9):6536-6549

The ciliary gene INPP5E confers dorsal telencephalic identity to human cortical organoids by negatively regulating Sonic hedgehog signaling.

Schembs L, Willems A, Hasenpusch-Theil K, Cooper JD, Whiting K, Burr K, Bøstrand SMK, Selvaraj BT, Chandran S, Theil T
Cell reports 2022 May 17;39(7):110811

Angiomotin isoform 2 promotes binding of PALS1 to KIF13B at primary cilia and regulates ciliary length and signaling.

Morthorst SK, Nielsen C, Farinelli P, Anvarian Z, Rasmussen CBR, Serra-Marques A, Grigoriev I, Altelaar M, Fürstenberg N, Ludwig A, Akhmanova A, Christensen ST, Pedersen LB
Journal of cell science 2022 Jun 15;135(12)

Cepharanthine hydrochloride inhibits the Wnt/β‑catenin/Hedgehog signaling axis in liver cancer.

Su GF, Huang ZX, Huang DL, Chen PX, Wang Y, Wang YF
Oncology reports 2022 Apr;47(4)

BRD4 promotes the migration and invasion of bladder cancer cells through the Sonic hedgehog signaling pathway and enhances cisplatin resistance.

Liu T, Zhang Z, Wang C, Huang H, Li Y
Biochemistry and cell biology = Biochimie et biologie cellulaire 2022 Apr;100(2):179-187

METTL3-mediated m6A modification of STEAP2 mRNA inhibits papillary thyroid cancer progress by blocking the Hedgehog signaling pathway and epithelial-to-mesenchymal transition.

Zhu Y, Peng X, Zhou Q, Tan L, Zhang C, Lin S, Long M
Cell death & disease 2022 Apr 18;13(4):358

Apatinib Suppresses Gastric Cancer Stem Cells Properties by Inhibiting the Sonic Hedgehog Pathway.

Cao W, Li Y, Sun H, Yang C, Zhu J, Xie C, Li X, Wu J, Geng S, Wang L, Sun L, Geng G, Han H, Zhong C
Frontiers in cell and developmental biology 2021;9:679806

Repurposing of posaconazole as a hedgehog/SMO signaling inhibitor for embryonal rhabdomyosarcoma therapy.

Sun J, Lin W, Li C, Ueki H, Xue R, Sadahira T, Hu H, Wada K, Li N, Liu C, Araki M, Xu A, Huang P
American journal of cancer research 2021;11(9):4528-4540

Epigallocatechin-3-gallate inhibits proliferation and triggers apoptosis in colon cancer via the hedgehog/phosphoinositide 3-kinase pathways.

Ding F, Yang S
Canadian journal of physiology and pharmacology 2021 Sep;99(9):910-920

Activation of the Hedgehog and Wnt/β-Catenin Signaling Pathways in Basal Cell Carcinoma.

Takada T
Case reports in dermatology 2021 Sep-Dec;13(3):506-512

Circular RNA circIPO11 drives self-renewal of liver cancer initiating cells via Hedgehog signaling.

Gu Y, Wang Y, He L, Zhang J, Zhu X, Liu N, Wang J, Lu T, He L, Tian Y, Fan Z
Molecular cancer 2021 Oct 14;20(1):132

GLI2 but not GLI1/GLI3 plays a central role in the induction of malignant phenotype of gallbladder cancer.

Ichimiya S, Onishi H, Nagao S, Koga S, Sakihama K, Nakayama K, Fujimura A, Oyama Y, Imaizumi A, Oda Y, Nakamura M
Oncology reports 2021 Mar;45(3):997-1010

Differential effects of EPA and DHA on DSS-induced colitis in mice and possible mechanisms involved.

Zhang Z, Xue Z, Yang H, Zhao F, Liu C, Chen J, Lu S, Zou Z, Zhou Y, Zhang X
Food & function 2021 Mar 1;12(4):1803-1817

Sterol and oxysterol synthases near the ciliary base activate the Hedgehog pathway.

Findakly S, Daggubati V, Garcia G, LaStella SA, Choudhury A, Tran C, Li A, Tong P, Garcia JQ, Puri N, Reiter JF, Xu L, Raleigh DR
The Journal of cell biology 2021 Jan 4;220(1)

MicroRNA miR-19b-3p mediated G protein γ subunit 7 (GNG7) loss contributes lung adenocarcinoma progression through activating Hedgehog signaling.

Zhao X, Zhang XC, Zang K, Yu ZH
Bioengineered 2021 Dec;12(1):7849-7858

Cigarette smoke supports stemness and epithelial-mesenchymal transition in bladder cancer stem cells through SHH signaling.

Sun X, Song J, Li E, Geng H, Li Y, Yu D, Zhong C
International journal of clinical and experimental pathology 2020;13(6):1333-1348

Primary cilium remodeling mediates a cell signaling switch in differentiating neurons.

Toro-Tapia G, Das RM
Science advances 2020 May;6(21):eabb0601

Meningioma cells express primary cilia but do not transduce ciliary Hedgehog signals.

Findakly S, Choudhury A, Daggubati V, Pekmezci M, Lang UE, Raleigh DR
Acta neuropathologica communications 2020 Jul 20;8(1):114

Exosomal Sonic Hedgehog derived from cancer-associated fibroblasts promotes proliferation and migration of esophageal squamous cell carcinoma.

Zhao G, Li H, Guo Q, Zhou A, Wang X, Li P, Zhang S
Cancer medicine 2020 Apr;9(7):2500-2513

Genistein inhibits nasopharyngeal cancer stem cells through sonic hedgehog signaling.

Zhang Q, Cao WS, Wang XQ, Zhang M, Lu XM, Chen JQ, Chen Y, Ge MM, Zhong CY, Han HY
Phytotherapy research : PTR 2019 Oct;33(10):2783-2791

TSPAN8 promotes cancer cell stemness via activation of sonic Hedgehog signaling.

Zhu R, Gires O, Zhu L, Liu J, Li J, Yang H, Ju G, Huang J, Ge W, Chen Y, Lu Z, Wang H
Nature communications 2019 Jun 28;10(1):2863

Sulforaphane inhibits gastric cancer stem cells via suppressing sonic hedgehog pathway.

Ge M, Zhang L, Cao L, Xie C, Li X, Li Y, Meng Y, Chen Y, Wang X, Chen J, Zhang Q, Shao J, Zhong C
International journal of food sciences and nutrition 2019 Aug;70(5):570-578

Effects of baicalein on pancreatic cancer stem cells via modulation of sonic Hedgehog pathway.

Song L, Chen X, Wang P, Gao S, Qu C, Liu L
Acta biochimica et biophysica Sinica 2018 Jun 1;50(6):586-596

Salinomycin suppresses cancer cell stemness and attenuates TGF-β-induced epithelial-mesenchymal transition of renal cell carcinoma cells.

Liu L, Wang Q, Mao J, Qin T, Sun Y, Yang J, Han Y, Li L, Li Q
Chemico-biological interactions 2018 Dec 25;296:145-153

Curcumin inhibits bladder cancer stem cells by suppressing Sonic Hedgehog pathway.

Wang D, Kong X, Li Y, Qian W, Ma J, Wang D, Yu D, Zhong C
Biochemical and biophysical research communications 2017 Nov 4;493(1):521-527

Curcumin Suppresses Lung Cancer Stem Cells via Inhibiting Wnt/β-catenin and Sonic Hedgehog Pathways.

Zhu JY, Yang X, Chen Y, Jiang Y, Wang SJ, Li Y, Wang XQ, Meng Y, Zhu MM, Ma X, Huang C, Wu R, Xie CF, Li XT, Geng SS, Wu JS, Zhong CY, Han HY
Phytotherapy research : PTR 2017 Apr;31(4):680-688

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Submitted by: Proteintech Group (provider)
Main image
Experimental details: The SMO antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human SMO. This antibody recognizes human antigen. The SMO antibody has been validated for the following applications: ELISA, IHC analysis.
Appendix: 20787-1-AP.pdf

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