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- References [184]
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- Product number
- 12592-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12592-1-AP, RRID:AB_11182486
- Product name
- FDX1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated FDX1 antibody (Cat. #12592-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Electroacupuncture Alleviates Oxidative Stress and Cuproptosis in Metabolic Dysfunction-Associated Steatotic Liver Disease Mice Through Activation of the NRF2/ARE Pathway.
SLC31A1 knockdown mitigates post-MI heart failure via regulation of copper metabolism.
Injectable Cu(2+) loaded rhein hydrogel for cross-amplifying osteosarcoma apoptosis and cuproptosis epitranscriptomically.
Hyaluronic acid-coated Cu/Mn Prussian blue nanocubes amplify cuproptosis and cGAS-STING signaling for synergistic prostate cancer therapy.
Glutathione metabolic reprogramming by ferroptosis inducers potentiates cuproptosis and antitumor immunity in osteosarcoma.
PD-L1 nanobody-engineered bacterial outer membrane vesicles delivering cuproptosis micelles for potentiated cancer immunotherapy.
Biomineralized Bacterial Biohybrid for Coordinated and Self-Sustained In Situ Synthesis of Antitumor Photothermal Agent and Photosensitizer.
Tudor domain-containing protein 9-targeting siRNA nanoparticles alleviate Pseudomonas aeruginosa lung injury in preclinical models by promoting neutrophil cuproptosis.
A degradable multi-metal-chelating stealth nanoplatform for dual ferroptosis/cuproptosis-enhanced metalloimmunotherapy in leukemia.
Decoding microglial metabolic cell death and PANoptosis hub genes in subacute phase of traumatic brain injury: a multi-omics and experimental validation study.
Conductive coordination nanozyme prodrugs precisely trigger pyroptosis, cuproptosis and ferroptosis for in situ cancer vaccination.
Tumor-Directed Disulfidptosis via Spatiotemporally Controlled Copper Bioorthogonal Activation.
Glutathione-depleting mitochondria-targeting nanodrugs for stress amplification and immune activation via synergistic photodynamic therapy and cuproptosis.
Copper depletion ameliorates neuronal damage after intracerebral hemorrhage.
Ginsenoside Rh1 sensitizes gastric cancer to cuproptosis and represses immune evasion.
Ginsenoside Ro alleviated cuproptosis induced by high oxalate via inhibiting zinc transporter ZnT1 in renal tubular epithelial cells.
Omeprazole-mediated nanodelivery of copper for synchronous remodeling of copper influx and efflux in cuproptotic glioblastoma therapy.
COA6 deficiency inhibits hepatocellular carcinoma progression by regulating cuproptosis through the JAK/STAT signaling pathway.
Xinfeng Capsule ameliorates RA joint injury by inhibiting cuproptosis via the METTL3/miR-221/222-3p/ATP7A Axis.
Vascular smooth muscle cell RNA-binding protein U2AF2 induces copper death by regulating C1qbp expression, delaying development of atherosclerosise.
Cuproptosis of bronchial epithelial cells triggers airway remodeling in chronic asthma.
Copper modulates cell fate through the PLK1-FOXO3a-β-catenin signaling pathway by differentially regulating cuproptosis and EMT.
Bimetallic nanoconjugate hijack Fe-S clusters to drive a closed-loop cuproptosis-ferroptosis strategy for osteosarcoma inhibition.
Nitric oxide-driven copper homeostasis and osteogenesis in cranial defect regeneration using l-arginine-loaded HKUST-1.
Lactate metabolism regulating nanosystem synergizes cuproptosis and ferroptosis to enhance cancer immunotherapy.
A Functional Nanocomposite Tri-Activates Cuproptosis, Ferroptosis, and Mitophagy Death Pathway to Oppose Malignancies.
SERPINE1-Driven MAPK Activation Enhances Cuproptosis Resistance and Angiogenic Potential in Colorectal Cancer.
Mettl1 mitigates sepsis-induced cardiomyopathy via inhibition of FDX1-dependent cuproptosis.
The EZH2-NEAT1 epigenetic axis promotes cuproptosis sensitivity and modulates cancer cell migration in colorectal cancer.
AT-101 inhibits the proliferation and invasion of tongue squamous carcinoma cells by targeting the miR-21-5p/FDX1 axis.
PDHA1-acetylation signaling suppresses cuproptosis to attenuate anti-androgen effect in prostate cancer.
Mitochondrial uncoupling sensitizes gastric cancer cells to elesclomol-induced cuproptosis via FDX1/DLAT upregulation.
Unraveling the role of cuproptosis in pulmonary fibrosis pathogenesis and prognosis: an integrative single-cell transcriptomics and microarray analysis.
PKA activation rescues myocardial injury elicited by silica nanoparticles through improving oxidative stress, mitochondrial health, and copper homeostasis.
Transdermal siRNA delivery via biomineralized nanoparticle-incorporated microneedles modulates cuproptosis-ferroptosis interaction for psoriasis therapy.
A precise theranostic nanoplatform amplifies anti-tumor efficacy via copper ionophores and sonodynamic therapy.
Copper-based nanozymes synergistically enhance Cuproptosis for psoriasis treatment.
YTHDF1/SLC39A4 signaling axis promotes gastric cancer cell proliferation by suppressing cuproptosis ex vivo and in vitro.
Multi-Ion Channel Nanomedicines Targeting Zinc Transporter 1/ATPase Copper Transporters Disrupt Copper/Iron Homeostasis to Enhance Tumor Immunotherapy.
m6A Modification of ATOX1 Inhibits Acute Myeloid Leukemia Progression by Promoting Cuproptosis.
Copper-Based Metal-Organic Framework Nanoplatform for miRNA Delivery: Synergistic Antitumor Therapy.
To Explore the Mechanism of Cuproptosis in Psoriasis Based on Bioinformatics and in vivo Experiments.
Machine Learning-Based Identification and Experimental Validation of Hub Ferroptosis-Related Cuproptosis Genes in Lupus Nephritis.
Suppressing chondrocyte cuproptosis by syringaresinol-4-O-β-d-glucoside alleviates gouty arthritis.
p53 enhances elesclomol-Cu-induced cuproptosis in hepatocellular carcinoma via FDXR-mediated FDX1 upregulation.
Assessing the prognostic and therapeutic value of cuproptosis-related genes in colon adenocarcinoma patients.
LncRNA PVT1 promotes cuproptosis through transcriptional activation of FDX1 in colorectal cancer.
CIAO1 as a crucial signature gene of cuproptosis in gastric cancer.
Phillygenin ameliorates myocardial ischemia-reperfusion injury by inhibiting cuproptosis via the autophagy-lysosome degradation of CTR1.
TRIM21-Mediated K11-Linked Ubiquitination of ID1 Suppresses Tumorigenesis and Promotes Cuproptosis in Esophageal Squamous Cell Carcinoma.
Metabolic Inhibitor Loaded Metal-Phenolic Nanocapsules Enable Synergistic Cancer Therapy through Cuproptosis and Immunometabolic Reprogramming.
SP600125 decreases cAMP/PKA-dependent steroid production through ATF4/DDIT3 activation in MA-10 Leydig cells.
Copper Chelation by Penicillamine Protects Against Doxorubicin-Induced Cardiomyopathy by Suppressing FDX1-Mediated Cuproptosis.
Light-Activated CD36-Targeted Cuproptosis Triggers Metabolic-Immune Synergy for Precision Breast Cancer Therapy.
Human cytomegalovirus protein UL13 targets to mitochondria to induce cuproptosis.
Copper ionophore complex ES-Cu synergizes with quercetin to target FDX1, promote cuproptosis, and reverse lenvatinib resistance in hepatocellular carcinoma cells.
Engineered biomimetic vesicles induce cuproptosis and disrupt efferocytosis for metastatic adenoid cystic carcinoma immunotherapy.
Dual molecularly imprinted nanocomposite with transferrin mediated glioma targeting and cholesterol exhaustion for synergistic cuproptosis/immune checkpoint blockade/immunogenic cell death.
Columbianadin targets TRIM7 to maintain P2X7 palmitoylation, inhibiting cuproptosis in synovial M2 macrophages.
Lithium Exposure Causes Trophoblast Cuproptosis by Upregulating FOXO1/STEAP4 Axis in Unexplained Miscarriage.
Cuproptosis in osteoarthritis: Exploring chondrocyte cuproptosis and therapeutic avenues.
Microwave-Activated Bacterial Biorobot for Multimodal Cancer Therapy.
Cuproptosis-driven astrocyte reactivity exacerbates experimental cerebral malaria pathogenesis.
Targeting the cuproptosis‑associated gene COL22A1 in glioblastoma using EMD‑1204831 and kaempferol.
Metabolome-wide association identifies ferredoxin-1 (FDX1) as a determinant of cholesterol metabolism and cardiovascular risk in Asian populations.
One-Step Symbiosis of Bimetallic Peroxides Nanoparticles to Induce Ferroptosis/Cuproptosis and Activate cGAS-STING Pathway for Enhanced Tumor Immunotherapy.
AKT1 Phosphorylates FDX1 to Promote Cuproptosis Resistance in Triple-Negative Breast Cancer.
NUDT21 lactylation reprograms alternative polyadenylation to promote cuproptosis resistance.
Novel Pt@PCN-Cu-induced cuproptosis amplifies αPD-L1 immunotherapy in pancreatic ductal adenocarcinoma through mitochondrial HK2-mediated PD-L1 upregulation.
FDX1 overexpression inhibits the growth and metastasis of clear cell renal cell carcinoma by upregulating FMR1 expression.
Functional nanozyme system for synergistic tumor immunotherapy via cuproptosis and ferroptosis activation.
Copper oxide nanoparticles induce pulmonary inflammation via triggering cellular cuproptosis.
Targeting FDX1 by trilobatin to inhibit cuproptosis in doxorubicin-induced cardiotoxicity.
Precision targeted melanoma therapy via cuproptosis/chemodynamic and chemotherapy: An engineering MCHS-CuMOF nanodelivery system.
Radiotherapy promotes cuproptosis and synergizes with cuproptosis inducers to overcome tumor radioresistance.
C5a/C5aR pathway blocking promoted CuS-mediated cancer therapy effect by inhibiting cuproptosis resistance.
Modulation of copper homeostasis and cuproptosis by PDHA1 in acute myeloid leukemia.
Increased CDKN2A expression correlates with resistance to platinum-based therapy and decreased infiltration of B lymphocytes in colon adenocarcinoma.
Molecular function validation and prognostic value analysis of the cuproptosis-related gene ferredoxin 1 in papillary thyroid carcinoma.
CuOTeDsP nanotherapeutics enhance cuproptosis-mediated immunotherapy by modulating cholesterol metabolism in bladder cancer.
Exploiting mitochondrial dysfunction to overcome BRAF inhibitor resistance in advanced melanoma: the role of disulfiram as a copper ionophore.
Cupric Doping Hollow Prussian Blue Nanoplatform for Enhanced Cholesterol Depletion: a Promising Strategy for Breast Cancer Therapy and Metastasis Inhibition.
A metal-organic framework functionalized CaO(2)-based cascade nanoreactor induces synergistic cuproptosis/ferroptosis and Ca(2+) overload-mediated mitochondrial damage for enhanced sono-chemodynamic immunotherapy.
p53 induces circFRMD4A to suppress cancer development through glycolytic reprogramming and cuproptosis.
Cuproptosis and Serine Metabolism Blockade Triggered by Copper-Based Prussian Blue Nanomedicine for Enhanced Tumor Therapy.
Modulation of the local angiotensin II: Suppression of ferroptosis and radiosensitivity in nasopharyngeal carcinoma via the HIF-1α-HILPDA axis.
Glutathione Induced In Situ Activation of Dual-Locked Cuproptosis Nanoamplifier with Glycolysis Metabolism Inhibition to Boost Cancer Immunotherapy.
UiO-66 MOFs-Based "Epi-Nano-Sonosensitizer" for Ultrasound-Driven Cascade Immunotherapy against B-Cell Lymphoma.
Regulating SLC7A11/GSH/GPX4 axis by glucose dyshomeostasis to simultaneously promote disulfidptosis, cuproptosis and ferroptosis.
Cu-doped dendritic biodegradable nanoplatforms for augmenting cuproptosis and tumor-starvation therapy through mitochondrial metabolic cascade modulation.
Biodegradable Cu-based sonozymes for tumor-specific cuproptosis-enhanced sono-immunotherapy through activating cGAS-STING pathway and sensitizing immune checkpoint blockade.
Clinically friendly smart hydrogel boosts cuproptosis and PD-L1 upregulation to enhance anti-tumor immunotherapy.
Carrier-Free Self-Assembled Nanoparticles for Triple-Amplified Tumor Chemodynamic Therapy and Cuproptosis Induction.
Disruption of NF-κB-Mediated Copper Homeostasis Sensitizes Breast Cancer to Cuproptosis.
Functional nano-nucleic acid platform promotes copper-induced gastric cancer cell death.
Targeting multiple genetic defects of mitochondrial diseases with a single bacterial lipoate protein ligase.
LRPPRC-Driven Oxidative Phosphorylation Is Associated with Elesclomol-Induced Cuproptosis in Ovarian Cancer.
Vitisin A inhibits liver fibrosis by promoting Nrf2/HO-1 pathway and inhibiting Cuproptosis.
TRIM14 Regulation of Copper Homeostasis and Cuproptosis: A New Strategy to Overcome Chemoresistance in Glioblastoma.
Copper ionophore elicits calpain-dependent paraptosis coincident with proteotoxic stress.
Melanoma MHC-I-membrane-encapsulated Cu@ferrihydrite induces ferroptosis/cuproptosis and systematic immunity against tumor.
Dapagliflozin Suppressed Cuproptosis and Myocardial Fibrosis in Myocardial Infarction Through HIF-1α/TGF-β Pathway.
High-Efficiency Carriers' Separation Strategy Based Ultrasmall-Bandgap CuWO(4) Sono-Enhances GSH Antagonism for Cuproptosis Cascade Immunotherapy.
Spinal cord ischemia reperfusion injury induces cuproptosis in neurons.
Copper-Induced Cuproptosis and Immunogenic Cell Death Synergize with Radiotherapy and PD-1 Blockade in Osteosarcoma.
Cu(OH)(2) nanopesticide induced liver dysfunction in mice by targeting lipoylated tricarboxylic acid cycle proteins via ferredoxin 1.
Engineering M2 macrophage-derived exosomes modulate activated T cell cuproptosis to promote immune tolerance in rheumatoid arthritis.
Multifunctional porous organic polymer-based hybrid nanoparticles for sonodynamically enhanced cuproptosis and synergistic tumor therapy.
Cancer-associated fibroblasts promote oral squamous cell carcinoma progression by targeting ATP7A via exosome-mediated paracrine miR-148b-3p.
Chlorophyllin exerts synergistic anti-tumor effect with gemcitabine in pancreatic cancer by inducing cuproptosis.
Impact of diabetes and metformin on cuproptosis and ferroptosis in breast cancer patients: an immunohistochemical analysis.
Copper-mediated SEC14L3 promotes cuproptosis to inhibit hepatocellular carcinoma growth via ERK/YY1/FDX1 axis.
o8G-modified circKIAA1797 promotes lung cancer development by inhibiting cuproptosis.
Endoplasmic reticulum stress related super-enhancers suppress cuproptosis via glycolysis reprogramming in lung adenocarcinoma.
Cuproptosis-related lncRNAs emerge as a novel signature for predicting prognosis in prostate carcinoma and functional experimental validation.
FDX2, an iron-sulfur cluster assembly factor, is essential to prevent cellular senescence, apoptosis or ferroptosis of ovarian cancer cells.
GSH exhaustion via inhibition of xCT-GSH-GPX4 pathway synergistically enhanced DSF/Cu-induced cuproptosis in myelodysplastic syndromes.
SP1/CTR1-mediated oxidative stress-induced cuproptosis in intervertebral disc degeneration.
Identification of diagnostic signature and immune infiltration for ischemic cardiomyopathy based on cuproptosis-related genes through bioinformatics analysis and experimental validation.
Novel Insights Into DLAT's Role in Alzheimer's Disease-Related Copper Toxicity Through Microglial Exosome Dynamics.
CuO Nanozymes Catalyze Cysteine and Glutathione Depletion Induced Ferroptosis and Cuproptosis for Synergistic Tumor Therapy.
Role of cuproptosis in mediating the severity of experimental malaria-associated acute lung injury/acute respiratory distress syndrome.
Multifunctional Copper-Phenolic Nanopills Achieve Comprehensive Polyamines Depletion to Provoke Enhanced Pyroptosis and Cuproptosis for Cancer Immunotherapy.
CircSpna2 attenuates cuproptosis by mediating ubiquitin ligase Keap1 to regulate the Nrf2-Atp7b signalling axis in depression after traumatic brain injury in a mouse model.
Three Birds with One Stone: Copper Ions Assisted Synergistic Cuproptosis/Chemodynamic/Photothermal Therapy by a Three-Pronged Approach.
Copper-Based Composites Nanoparticles Improve Triple-Negative Breast Cancer Treatment with Induction of Apoptosis-Cuproptosis and Immune Activation.
Rhomboid-like 2 correlated with TME infiltration inhibits cuproptosis-related genes and drives malignant phenotype in clear cell renal cell carcinoma.
Ferredoxin 1: a gatekeeper in halting lung adenocarcinoma progression through activation of the GPRIN2 signaling pathway.
MUC20 regulated by extrachromosomal circular DNA attenuates proteasome inhibitor resistance of multiple myeloma by modulating cuproptosis.
A cuproptosis-related gene expression signature predicting clinical prognosis and immune responses in intrahepatic cholangiocarcinoma detected by single-cell RNA sequence analysis.
Integrated profiling identifies ferredoxin 1 as an immune-related biomarker of malignant phenotype in glioma.
Clinical features and molecular landscape of cuproptosis signature-related molecular subtype in gastric cancer.
Elesclomol-copper synergizes with imidazole ketone erastin by promoting cuproptosis and ferroptosis in myelodysplastic syndromes.
Mitochondrial-Targeted Copper Delivery for Cuproptosis-Based Synergistic Cancer Therapy.
Molecular characterization and clinical relevance of metabolic signature subtypes in gastric cancer.
Potential of lncRNAs to regulate cuproptosis in hepatocellular carcinoma: Establishment and validation of a novel risk model.
Inhibiting the compensatory elevation of xCT collaborates with disulfiram/copper-induced GSH consumption for cascade ferroptosis and cuproptosis.
Combination of the cuproptosis inducer disulfiram and anti‑PD‑L1 abolishes NSCLC resistance by ATP7B to regulate the HIF‑1 signaling pathway.
Deep learning enables the discovery of a novel cuproptosis-inducing molecule for the inhibition of hepatocellular carcinoma.
Copper-coordinated nanoassemblies based on photosensitizer-chemo prodrugs and checkpoint inhibitors for enhanced apoptosis-cuproptosis and immunotherapy.
Protein phosphatase 1 regulatory subunit 15 A promotes translation initiation and induces G2M phase arrest during cuproptosis in cancers.
Novel immune cross-talk between inflammatory bowel disease and IgA nephropathy.
Sirtuin 7 ameliorates cuproptosis, myocardial remodeling and heart dysfunction in hypertension through the modulation of YAP/ATP7A signaling.
Cuprorivaite microspheres inhibit cuproptosis and oxidative stress in osteoarthritis via Wnt/β-catenin pathway.
Synergistic enhancement of low-dose radiation therapy via cuproptosis and metabolic reprogramming for radiosensitization in in situ hepatocellular carcinoma.
Curcuminoid PBPD induces cuproptosis and endoplasmic reticulum stress in cervical cancer via the Notch1/RBP-J/NRF2/FDX1 pathway.
Copper Homeostasis Based on Cuproptosis-Related Signature Optimizes Molecular Subtyping and Treatment of Glioma.
Injectable Hydrogel-Encapsulating Pickering Emulsion for Overcoming Lenvatinib-Resistant Hepatocellular Carcinoma via Cuproptosis Induction and Stemness Inhibition.
Eupalinolide B suppresses pancreatic cancer by ROS generation and potential cuproptosis.
Cellular Trojan Horse initiates bimetallic Fe-Cu MOF-mediated synergistic cuproptosis and ferroptosis against malignancies.
Identification of core cuprotosis-correlated biomarkers in abdominal aortic aneurysm immune microenvironment based on bioinformatics.
Identification of cuproptosis-related subtypes and the development of a prognostic model in glioma.
Identification of a cuproptosis and copper metabolism gene-related lncRNAs prognostic signature associated with clinical and immunological characteristics of hepatocellular carcinoma.
ITGB1-mediated molecular landscape and cuproptosis phenotype induced the worse prognosis in diffuse gastric cancer.
Lipoylation is dependent on the ferredoxin FDX1 and dispensable under hypoxia in human cells.
Evaluation the role of cuproptosis-related genes in the pathogenesis, diagnosis and molecular subtypes identification of atherosclerosis.
Lactylation of METTL16 promotes cuproptosis via m(6)A-modification on FDX1 mRNA in gastric cancer.
Targeting the TCA cycle through cuproptosis confers synthetic lethality on ARID1A-deficient hepatocellular carcinoma.
4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to promote cuproptosis in colorectal cancer.
FDX1-dependent and independent mechanisms of elesclomol-mediated intracellular copper delivery.
A novel cuproptosis-related gene signature to predict prognosis in Glioma.
Expression of Ferredoxin1 in cisplatin‑resistant ovarian cancer cells confers their resistance against ferroptosis induced by cisplatin.
Critical role of antioxidant programs in enzalutamide-resistant prostate cancer.
Confirmation of the predictive function of cuproptosis-related gene FDX1 in clear cell renal carcinoma using qRT-PCR and western blotting.
Sinapic and ferulic acid phenethyl esters increase the expression of steroidogenic genes in MA-10 tumor Leydig cells.
SP1 impacts the primordial to primary follicle transition by regulating cholesterol metabolism in granulosa cells.
Glutathione ameliorates the meiotic defects of copper exposed ovine oocytes via inhibiting the mitochondrial dysfunctions.
Bioinformatics analysis and experimental validation of cuproptosis-related lncRNA LINC02154 in clear cell renal cell carcinoma.
Dexmedetomidine enables copper homeostasis in cerebral ischemia/reperfusion via ferredoxin 1.
Integrated bioinformatics and experiment revealed that cuproptosis is the potential common pathogenesis of three kinds of primary cardiomyopathy.
FDX1 Is Required for the Biogenesis of Mitochondrial Cytochrome c Oxidase in Mammalian Cells.
Comprehensive analysis of cuproptosis-related immune biomarker signature to enhance prognostic accuracy in gastric cancer.
A Novel Cuprotosis-Related Gene FDX1 Signature for Overall Survival Prediction in Clear Cell Renal Cell Carcinoma Patients.
FDX1 expression predicts favourable prognosis in clear cell renal cell carcinoma identified by bioinformatics and tissue microarray analysis.
Multi-omics pan-cancer study of cuproptosis core gene FDX1 and its role in kidney renal clear cell carcinoma.
Ferredoxin 1 is a cuproptosis-key gene responsible for tumor immunity and drug sensitivity: A pan-cancer analysis.
A novel signature to guide osteosarcoma prognosis and immune microenvironment: Cuproptosis-related lncRNA.
Role of cuproptosis-related gene in lung adenocarcinoma.
Establishment and experimental validation of a novel cuproptosis-related gene signature for prognostic implication in cholangiocarcinoma.
Cuproptosis-Related MiR-21-5p/FDX1 Axis in Clear Cell Renal Cell Carcinoma and Its Potential Impact on Tumor Microenvironment.
SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells.
Maintaining Iron Homeostasis Is the Key Role of Lysosomal Acidity for Cell Proliferation.
Mitochondrial metabolism promotes adaptation to proteotoxic stress.
Genomic expression profiles in cumulus cells derived from germinal vesicle and MII mouse oocytes.
Deng J, Liao C, Liu H, Tang X, Yang Y, Yang Y, Guo X, Zhang S, Xing K, Liao M, Tang C
Diabetes, metabolic syndrome and obesity : targets and therapy 2026;19:568066
Diabetes, metabolic syndrome and obesity : targets and therapy 2026;19:568066
SLC31A1 knockdown mitigates post-MI heart failure via regulation of copper metabolism.
Wei Q, Zhou H, Sun J, Qin L
Frontiers in immunology 2026;17:1707203
Frontiers in immunology 2026;17:1707203
Injectable Cu(2+) loaded rhein hydrogel for cross-amplifying osteosarcoma apoptosis and cuproptosis epitranscriptomically.
Zhu J, Zhou T, Tang X, Gao Y, Teng Q, Zhang Y, Lv Z, Chen X, Zou J, Shi H
Biomaterials 2026 Sep;332:124170
Biomaterials 2026 Sep;332:124170
Hyaluronic acid-coated Cu/Mn Prussian blue nanocubes amplify cuproptosis and cGAS-STING signaling for synergistic prostate cancer therapy.
Yao X, Ruan Y, Rao T, Lin F, Zhang W
International journal of biological macromolecules 2026 May;362:152036
International journal of biological macromolecules 2026 May;362:152036
Glutathione metabolic reprogramming by ferroptosis inducers potentiates cuproptosis and antitumor immunity in osteosarcoma.
Xu S, Zhao Y, Yao J, Chen H, Lyu J, Ding Y, Zeng H, Chen H, Hu C, Zhao C
International immunopharmacology 2026 May 15;177:116495
International immunopharmacology 2026 May 15;177:116495
PD-L1 nanobody-engineered bacterial outer membrane vesicles delivering cuproptosis micelles for potentiated cancer immunotherapy.
Li Z, Liang D, Huo M, Guan L, Liu Z, Gu F, Guan X, Chen L
Biomaterials advances 2026 Mar;180:214552
Biomaterials advances 2026 Mar;180:214552
Biomineralized Bacterial Biohybrid for Coordinated and Self-Sustained In Situ Synthesis of Antitumor Photothermal Agent and Photosensitizer.
Jin K, Zhang Y, Huang Y, Yu L, Zhong Y, Niu L, Wu Y
Advanced healthcare materials 2026 Mar;15(10):e04077
Advanced healthcare materials 2026 Mar;15(10):e04077
Tudor domain-containing protein 9-targeting siRNA nanoparticles alleviate Pseudomonas aeruginosa lung injury in preclinical models by promoting neutrophil cuproptosis.
Zhang W, Li H, Jia H, Xuan W, Ding L, Tan Z, Wu Q, Zhao M, Wu X
Nature communications 2026 Mar 6;17(1)
Nature communications 2026 Mar 6;17(1)
A degradable multi-metal-chelating stealth nanoplatform for dual ferroptosis/cuproptosis-enhanced metalloimmunotherapy in leukemia.
Wang Y, Xu J, Bai W, Zhang Z, Ma C, Tan Y, Zhang Z, Liu W, Wu Y, Liu J, Lei H, Xu H, Weng W, Huang M, Feng X, Zhu L, Yang L, Zhu Q, Wu YL
Journal of nanobiotechnology 2026 Mar 21;24(1)
Journal of nanobiotechnology 2026 Mar 21;24(1)
Decoding microglial metabolic cell death and PANoptosis hub genes in subacute phase of traumatic brain injury: a multi-omics and experimental validation study.
Wu Z, Yang BY, Lai JQ, Lin SH, Lin L, Chen JL, Pan JX, Ruan YX, Chen XR
Apoptosis : an international journal on programmed cell death 2026 Mar 19;31(3)
Apoptosis : an international journal on programmed cell death 2026 Mar 19;31(3)
Conductive coordination nanozyme prodrugs precisely trigger pyroptosis, cuproptosis and ferroptosis for in situ cancer vaccination.
Wang Y, Zhao H, Sun K, Deng D, Liu G, Li L, Liu T, Bao L, Xu W, Chen C
Signal transduction and targeted therapy 2026 Mar 16;11(1)
Signal transduction and targeted therapy 2026 Mar 16;11(1)
Tumor-Directed Disulfidptosis via Spatiotemporally Controlled Copper Bioorthogonal Activation.
Yin Y, Yu W, Shen Z, Yuan S, Cao K, Liu HK, Liu Y
ACS nano 2026 Mar 10;20(9):7569-7588
ACS nano 2026 Mar 10;20(9):7569-7588
Glutathione-depleting mitochondria-targeting nanodrugs for stress amplification and immune activation via synergistic photodynamic therapy and cuproptosis.
Zhang P, Lin H, Guan Q, Xiong S, Tian Z, Wu W, Dai T, Wang X, Ruan J, Yang S, Dou H
Acta biomaterialia 2026 Jun;216:389-402
Acta biomaterialia 2026 Jun;216:389-402
Copper depletion ameliorates neuronal damage after intracerebral hemorrhage.
Zhang W, Wu G, Wang L, Ren S
Neurochemistry international 2026 Jun;196:106150
Neurochemistry international 2026 Jun;196:106150
Ginsenoside Rh1 sensitizes gastric cancer to cuproptosis and represses immune evasion.
Zhao D, Yuan Q, Wang H, Yang H, Yang L
Free radical biology & medicine 2026 Jul;250:399-410
Free radical biology & medicine 2026 Jul;250:399-410
Ginsenoside Ro alleviated cuproptosis induced by high oxalate via inhibiting zinc transporter ZnT1 in renal tubular epithelial cells.
Li C, Zhou Y, Nie Y, Fu J, Zeng J, Zhang S, Han L, Li Z, Yang H, Li S, Yu B, Ying X, Wu W
Journal of ginseng research 2026 Jan;50(1):100908
Journal of ginseng research 2026 Jan;50(1):100908
Omeprazole-mediated nanodelivery of copper for synchronous remodeling of copper influx and efflux in cuproptotic glioblastoma therapy.
Feng W, Weng C, Li C, Yang R, Shi W, Liu Y, Ge P, Zhang H
Acta biomaterialia 2026 Jan;210:499-515
Acta biomaterialia 2026 Jan;210:499-515
COA6 deficiency inhibits hepatocellular carcinoma progression by regulating cuproptosis through the JAK/STAT signaling pathway.
Tian K, Yang Y, Niu X, Wei X, Zhang M, Zhou Y, Yang M, Sun H, Zhu L, Liu F
Biochimica et biophysica acta. Molecular cell research 2026 Jan;1873(1):120065
Biochimica et biophysica acta. Molecular cell research 2026 Jan;1873(1):120065
Xinfeng Capsule ameliorates RA joint injury by inhibiting cuproptosis via the METTL3/miR-221/222-3p/ATP7A Axis.
Wang H, Wang A, Liu J, Zhu NF, Cao Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157644
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157644
Vascular smooth muscle cell RNA-binding protein U2AF2 induces copper death by regulating C1qbp expression, delaying development of atherosclerosise.
Yang Y, Chen H, Yu Q, Chen Q, Zhou X, Zhou S, Liu T, Lin J
Biological research 2026 Jan 28;59(1)
Biological research 2026 Jan 28;59(1)
Cuproptosis of bronchial epithelial cells triggers airway remodeling in chronic asthma.
Wang M, Liu C, Li Z, Wang Y, Li Y, Pei F
Scientific reports 2026 Jan 13;16(1):4621
Scientific reports 2026 Jan 13;16(1):4621
Copper modulates cell fate through the PLK1-FOXO3a-β-catenin signaling pathway by differentially regulating cuproptosis and EMT.
Lee HJ, Park JH, Kim DY, Kim DY, Yi MJ, Choi WS, Na HH, Chae S, Oh YT, Kim KC
Apoptosis : an international journal on programmed cell death 2026 Jan 10;31(1):12
Apoptosis : an international journal on programmed cell death 2026 Jan 10;31(1):12
Bimetallic nanoconjugate hijack Fe-S clusters to drive a closed-loop cuproptosis-ferroptosis strategy for osteosarcoma inhibition.
Liu G, Tang R, Wang C, Yu D, Wang Z, Yang H, Wei J, Zhu S, Gao F, Yuan F, Pan B
Journal of colloid and interface science 2026 Feb;703(Pt 1):139052
Journal of colloid and interface science 2026 Feb;703(Pt 1):139052
Nitric oxide-driven copper homeostasis and osteogenesis in cranial defect regeneration using l-arginine-loaded HKUST-1.
Zhou F, Xu Z, Wang Q, Wang D, Bai F, Xiang L, Man Y, Wu Y
Biomaterials 2026 Feb;325:123557
Biomaterials 2026 Feb;325:123557
Lactate metabolism regulating nanosystem synergizes cuproptosis and ferroptosis to enhance cancer immunotherapy.
Zhi H, Yin W, Chen S, Zhang X, Yang Z, Man F, Li R, Cai Y, Li Y, You C, Li Y, Li Y, Dong H
Biomaterials 2026 Feb;325:123538
Biomaterials 2026 Feb;325:123538
A Functional Nanocomposite Tri-Activates Cuproptosis, Ferroptosis, and Mitophagy Death Pathway to Oppose Malignancies.
Deng K, Gao W, Wen Y, Huang J, Li X, Yang X, Wu M
Advanced healthcare materials 2026 Feb;15(6):e03530
Advanced healthcare materials 2026 Feb;15(6):e03530
SERPINE1-Driven MAPK Activation Enhances Cuproptosis Resistance and Angiogenic Potential in Colorectal Cancer.
Gao P, Li H, Luo J, Zhang C, Wei J, Li X, Ma H
Digestive diseases and sciences 2026 Feb 9;
Digestive diseases and sciences 2026 Feb 9;
Mettl1 mitigates sepsis-induced cardiomyopathy via inhibition of FDX1-dependent cuproptosis.
Siang W, Guoyun W, Yan F, Wenji L
Gene 2026 Feb 5;978:149892
Gene 2026 Feb 5;978:149892
The EZH2-NEAT1 epigenetic axis promotes cuproptosis sensitivity and modulates cancer cell migration in colorectal cancer.
Li R, Tao Q, Chen X, Liu C, Zhan H, Wang C, Wang X, Lin Y
Journal of gastrointestinal oncology 2026 Feb 28;17(1):18
Journal of gastrointestinal oncology 2026 Feb 28;17(1):18
AT-101 inhibits the proliferation and invasion of tongue squamous carcinoma cells by targeting the miR-21-5p/FDX1 axis.
Fu S, Cui QY, Tuo XY, Wu Y, Ji P
Scientific reports 2026 Feb 24;16(1)
Scientific reports 2026 Feb 24;16(1)
PDHA1-acetylation signaling suppresses cuproptosis to attenuate anti-androgen effect in prostate cancer.
Zhuang R, Zhou Q, Cheng B, Peng S, Xiong Z, Xie Z, Lin W, Su T, Li Z, Yao K, Wu Z, Huang H, Li K
Cell death & disease 2026 Feb 23;17(1)
Cell death & disease 2026 Feb 23;17(1)
Mitochondrial uncoupling sensitizes gastric cancer cells to elesclomol-induced cuproptosis via FDX1/DLAT upregulation.
Lu Y, Li Y, Sun X, Li X, Zhao S, Fang Y, Qiu W, Luo C, Qi W
Free radical biology & medicine 2026 Feb 16;244:284-295
Free radical biology & medicine 2026 Feb 16;244:284-295
Unraveling the role of cuproptosis in pulmonary fibrosis pathogenesis and prognosis: an integrative single-cell transcriptomics and microarray analysis.
Chen M, Chen J, Zhang J, Zhu Y, Meng X, Yang Z, Wang R
Molecular and cellular biochemistry 2026 Apr;481(4):1857-1874
Molecular and cellular biochemistry 2026 Apr;481(4):1857-1874
PKA activation rescues myocardial injury elicited by silica nanoparticles through improving oxidative stress, mitochondrial health, and copper homeostasis.
Guo C, Zhao X, Zhu Y, Chen M, Li Y
Materials today. Bio 2026 Apr;37:103021
Materials today. Bio 2026 Apr;37:103021
Transdermal siRNA delivery via biomineralized nanoparticle-incorporated microneedles modulates cuproptosis-ferroptosis interaction for psoriasis therapy.
Hao L, Yu P, Yan R, Li K, Luo Z, Xiang S, Wang Y, Fang C, Wang G, Ma S, Peng C, Hu S, Liu P
Materials today. Bio 2026 Apr;37:102991
Materials today. Bio 2026 Apr;37:102991
A precise theranostic nanoplatform amplifies anti-tumor efficacy via copper ionophores and sonodynamic therapy.
Luo X, Wang X, Li S, Chen Q, Song J, Chen J
Materials today. Bio 2026 Apr;37:102957
Materials today. Bio 2026 Apr;37:102957
Copper-based nanozymes synergistically enhance Cuproptosis for psoriasis treatment.
Zhou J, Yu N, Yang X, Li S, Huang M, Pang T, Zhong D, Wen Y, Liu H
Materials today. Bio 2026 Apr;37:102855
Materials today. Bio 2026 Apr;37:102855
YTHDF1/SLC39A4 signaling axis promotes gastric cancer cell proliferation by suppressing cuproptosis ex vivo and in vitro.
Su J, Qi J, Xu B, Wang J, Chaulagain RP, Chen H, Li N, Jiang X, Xu L, Li F, Mao W, Jin S
Cancer gene therapy 2026 Apr 29;
Cancer gene therapy 2026 Apr 29;
Multi-Ion Channel Nanomedicines Targeting Zinc Transporter 1/ATPase Copper Transporters Disrupt Copper/Iron Homeostasis to Enhance Tumor Immunotherapy.
Ma G, Li Y, Li X, Yu D, Chao M, Li J, Guo J, Wang K, Liu Z, Sun R, Gao F
ACS nano 2026 Apr 21;20(15):11801-11821
ACS nano 2026 Apr 21;20(15):11801-11821
m6A Modification of ATOX1 Inhibits Acute Myeloid Leukemia Progression by Promoting Cuproptosis.
Peng J, Fu X, Li S, Hu C, Zhao X, Peng J
Cancer research communications 2026 Apr 1;6(4):714-727
Cancer research communications 2026 Apr 1;6(4):714-727
Copper-Based Metal-Organic Framework Nanoplatform for miRNA Delivery: Synergistic Antitumor Therapy.
Tu M, Deng X, Lai B, Liu J, Tao Y, Xu S, Li X, Niu X, Li Z, Huang J, Li J, Mao S, Ouyang X, Cao J
International journal of nanomedicine 2025;20:8675-8692
International journal of nanomedicine 2025;20:8675-8692
To Explore the Mechanism of Cuproptosis in Psoriasis Based on Bioinformatics and in vivo Experiments.
Ma Y, Sun Y, Yao J, Zhang J, Wang H, Yang S
Journal of inflammation research 2025;18:17433-17456
Journal of inflammation research 2025;18:17433-17456
Machine Learning-Based Identification and Experimental Validation of Hub Ferroptosis-Related Cuproptosis Genes in Lupus Nephritis.
Zhang S, Hu W, Zhang Y, Huang C, He Z, Xu J, Lin S, Yang B, Chen X
Journal of inflammation research 2025;18:11335-11353
Journal of inflammation research 2025;18:11335-11353
Suppressing chondrocyte cuproptosis by syringaresinol-4-O-β-d-glucoside alleviates gouty arthritis.
Fu S, Du H, Ling X, Wang H, Chen J, Zhang H, Chen W, Liu C, Ma H, Lin C, Ma P, Qin A
Frontiers in pharmacology 2025;16:1565422
Frontiers in pharmacology 2025;16:1565422
p53 enhances elesclomol-Cu-induced cuproptosis in hepatocellular carcinoma via FDXR-mediated FDX1 upregulation.
Liu X, Qu H, Li J, Sun X, Wang Z, Wang D, Bai X, Li X
Frontiers in oncology 2025;15:1584811
Frontiers in oncology 2025;15:1584811
Assessing the prognostic and therapeutic value of cuproptosis-related genes in colon adenocarcinoma patients.
Ye Z, Song Y, Zhu M, Zheng F, Qin W, Li X, Wang P, Li Z, Chen K, Li A
Frontiers in cell and developmental biology 2025;13:1550982
Frontiers in cell and developmental biology 2025;13:1550982
LncRNA PVT1 promotes cuproptosis through transcriptional activation of FDX1 in colorectal cancer.
Ma J, Zhang Y, Sun Z, Guo H, Li X, Cai J, Zhang M, Chen M, Jiang J, Zhang L
Redox biology 2025 Sep;85:103722
Redox biology 2025 Sep;85:103722
CIAO1 as a crucial signature gene of cuproptosis in gastric cancer.
Qu J, Yang C, Zhou S, Zhao B, Tong Q, Zheng L
Oncology letters 2025 Sep;30(3):440
Oncology letters 2025 Sep;30(3):440
Phillygenin ameliorates myocardial ischemia-reperfusion injury by inhibiting cuproptosis via the autophagy-lysosome degradation of CTR1.
Chen G, Wei M, Zhao CY, Zhang AY, Su JB, Ni ZR, Cai WW, Hou B, Du B, Liu MH, Xu GW, Yang L, Xu AJ, Wen YY, Wang J, Zou H, Zhuang YY, Xing HY, He T, Li YF, Lu QB, Zhu J, Zhu XX, Li KL, Sun HJ
Free radical biology & medicine 2025 Sep;237:542-557
Free radical biology & medicine 2025 Sep;237:542-557
TRIM21-Mediated K11-Linked Ubiquitination of ID1 Suppresses Tumorigenesis and Promotes Cuproptosis in Esophageal Squamous Cell Carcinoma.
Li L, Wang Y, Tian R, Yang T, Liu Y, Shan B, Zhao L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(35):e02501
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(35):e02501
Metabolic Inhibitor Loaded Metal-Phenolic Nanocapsules Enable Synergistic Cancer Therapy through Cuproptosis and Immunometabolic Reprogramming.
Li B, Hu H, Li S, Wang X, Ma Z, Zhao W, Song Y, Jiao J, Xu F, Duan X, Zhang G
ACS applied materials & interfaces 2025 Sep 17;17(37):51659-51670
ACS applied materials & interfaces 2025 Sep 17;17(37):51659-51670
SP600125 decreases cAMP/PKA-dependent steroid production through ATF4/DDIT3 activation in MA-10 Leydig cells.
Basque A, Izichkis LS, Martin LJ
Molecular and cellular endocrinology 2025 Sep 15;607:112613
Molecular and cellular endocrinology 2025 Sep 15;607:112613
Copper Chelation by Penicillamine Protects Against Doxorubicin-Induced Cardiomyopathy by Suppressing FDX1-Mediated Cuproptosis.
El-Nablaway M, Sonpol HMA, Elewa YHA, Ali MAM, Adel M, Zayed ES, Alhelf M, Didamoony MA, Dawood AF, Embaby EM, El-Bayoumi KS, El-Saeed WS
Biomolecules 2025 Sep 15;15(9)
Biomolecules 2025 Sep 15;15(9)
Light-Activated CD36-Targeted Cuproptosis Triggers Metabolic-Immune Synergy for Precision Breast Cancer Therapy.
Wang S, Shen Y, Hu B, Wu Q, Wang N, Wang Z, Zhang Z, Li Y, Jiang J
ACS applied materials & interfaces 2025 Sep 10;17(36):50317-50336
ACS applied materials & interfaces 2025 Sep 10;17(36):50317-50336
Human cytomegalovirus protein UL13 targets to mitochondria to induce cuproptosis.
Yang XM, Lei YL, Zhang Y, Wang SH, Ren P, Li S, Yi XM
Biochemical and biophysical research communications 2025 Sep 1;777:152330
Biochemical and biophysical research communications 2025 Sep 1;777:152330
Copper ionophore complex ES-Cu synergizes with quercetin to target FDX1, promote cuproptosis, and reverse lenvatinib resistance in hepatocellular carcinoma cells.
Yang L, Pi P, Zhang M, Jiang Y, Wu T, Qing L, Wang H, Ma M, Zhang Z, Yang H, Tian Q, Lu X, Huang G, Zhao J, Liang B
Journal of advanced research 2025 Sep 1;
Journal of advanced research 2025 Sep 1;
Engineered biomimetic vesicles induce cuproptosis and disrupt efferocytosis for metastatic adenoid cystic carcinoma immunotherapy.
Li M, Dong W, Cui Y, Li J, Yang C, Zhang D, Fu X
Materials today. Bio 2025 Oct;34:102233
Materials today. Bio 2025 Oct;34:102233
Dual molecularly imprinted nanocomposite with transferrin mediated glioma targeting and cholesterol exhaustion for synergistic cuproptosis/immune checkpoint blockade/immunogenic cell death.
Zhao Y, Yuan J, Qi Y, Sun M, Zhang Y, Zhang G, Su X, Song M, Lv R, Shi Y, Zhao L
Materials today. Bio 2025 Oct;34:102209
Materials today. Bio 2025 Oct;34:102209
Columbianadin targets TRIM7 to maintain P2X7 palmitoylation, inhibiting cuproptosis in synovial M2 macrophages.
Li Z, Huang Z, Liao X, Li H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Oct;146:157091
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Oct;146:157091
Lithium Exposure Causes Trophoblast Cuproptosis by Upregulating FOXO1/STEAP4 Axis in Unexplained Miscarriage.
Xing S, Lin Y, Sun Y, Yue X, Fan Q, Nie J, Zhang Z, Liu Y, Yang J, Kang Q, Wang Y, Yan H, Tian C, Chang Y, Zhang H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(38):e02139
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(38):e02139
Cuproptosis in osteoarthritis: Exploring chondrocyte cuproptosis and therapeutic avenues.
Hua H, Cheng F, Meng Z, Zhang A, Li M, Zhang M, Lou P, Zhu Y, Tong P, Zhang Y
Journal of orthopaedic translation 2025 Nov;55:293-308
Journal of orthopaedic translation 2025 Nov;55:293-308
Microwave-Activated Bacterial Biorobot for Multimodal Cancer Therapy.
Zhuang H, Zhang Y, Fu Y, Ke D, Chen Q, Shao S, Xue P, Chen Y, Zeng X, Yan S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(41):e04603
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(41):e04603
Cuproptosis-driven astrocyte reactivity exacerbates experimental cerebral malaria pathogenesis.
Hou X, Mo X, Zhang X, Wang Q, Chen X, Lai C, Gao J, Wu L, Liu W, He J, Zeng X, Yin H, Deng Z, Liu T, Ye M, Liu Z, Jin X, Song J, Wang J, Huang B
Parasites & vectors 2025 Nov 10;18(1):454
Parasites & vectors 2025 Nov 10;18(1):454
Targeting the cuproptosis‑associated gene COL22A1 in glioblastoma using EMD‑1204831 and kaempferol.
Chen Y, Zhang Y, Yang H, Liu Q, Sui R, Shi J, Liang H, Liu J, Xu H, Piao H
International journal of oncology 2025 May;66(5)
International journal of oncology 2025 May;66(5)
Metabolome-wide association identifies ferredoxin-1 (FDX1) as a determinant of cholesterol metabolism and cardiovascular risk in Asian populations.
Sadhu N, Dalan R, Jain PR, Lee CJM, Pakkiri LS, Tay KY, Mina TH, Low D, Min Y, Ackers-Johnson M, Thi TT, Kota VG, Shi Y, Liu Y, Yu H, Lai V, Yang Y, Tay D, Ng HK, Wang X, Wong KE, Lam M, Guan XL, Bertin N, Wong E, Best J, Sarangarajan R, Elliott P, Riboli E, Lee J, Lee ES, Ngeow J, Tan P, Cheung C, Drum CL, Foo RS, Michelotti GA, Yu H, Sheridan PA, Loh M, Chambers JC
Nature cardiovascular research 2025 May;4(5):567-583
Nature cardiovascular research 2025 May;4(5):567-583
One-Step Symbiosis of Bimetallic Peroxides Nanoparticles to Induce Ferroptosis/Cuproptosis and Activate cGAS-STING Pathway for Enhanced Tumor Immunotherapy.
Liu B, Chen X, Zhu Y, Chen H, Tan J, Yang Z, Li J, Zheng P, Feng L, Wang Q, Gai S, Zhong L, Yang P, Cheng Z, Lin J
Advanced materials (Deerfield Beach, Fla.) 2025 May;37(21):e2500337
Advanced materials (Deerfield Beach, Fla.) 2025 May;37(21):e2500337
AKT1 Phosphorylates FDX1 to Promote Cuproptosis Resistance in Triple-Negative Breast Cancer.
Sun Z, Xu H, Lu G, Yang C, Gao X, Zhang J, Liu X, Chen Y, Wang K, Guo J, Li J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(17):e2408106
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(17):e2408106
NUDT21 lactylation reprograms alternative polyadenylation to promote cuproptosis resistance.
Lin J, Yin Y, Cao J, Zhang Y, Chen J, Chen R, Zou B, Huang C, Lv Y, Xu S, Yang H, Lin P, Xie D
Cell discovery 2025 May 28;11(1):52
Cell discovery 2025 May 28;11(1):52
Novel Pt@PCN-Cu-induced cuproptosis amplifies αPD-L1 immunotherapy in pancreatic ductal adenocarcinoma through mitochondrial HK2-mediated PD-L1 upregulation.
Wang P, Guo W, Liu S, Li S, Li J, Ding B, Yin F, Yang Y, Li X, Cao P, Ma C, Zhang W, Song Y, Geng Y, Liu L, Hu J, Hao J, Feng Y
Journal of experimental & clinical cancer research : CR 2025 May 17;44(1):149
Journal of experimental & clinical cancer research : CR 2025 May 17;44(1):149
FDX1 overexpression inhibits the growth and metastasis of clear cell renal cell carcinoma by upregulating FMR1 expression.
Yang W, Wu C, Jiang C, Jing T, Lu M, Xia D, Peng D
Cell death discovery 2025 Mar 21;11(1):115
Cell death discovery 2025 Mar 21;11(1):115
Functional nanozyme system for synergistic tumor immunotherapy via cuproptosis and ferroptosis activation.
Gu L, Sun Y, Bai T, Shao S, Tang S, Xue P, Cai W, Qin X, Zeng X, Yan S
Journal of nanobiotechnology 2025 Mar 15;23(1):212
Journal of nanobiotechnology 2025 Mar 15;23(1):212
Copper oxide nanoparticles induce pulmonary inflammation via triggering cellular cuproptosis.
Zhang X, Peng Z, Wang Q, Zhang W, Bu Q, Sun D
Toxicology 2025 Jun;514:154131
Toxicology 2025 Jun;514:154131
Targeting FDX1 by trilobatin to inhibit cuproptosis in doxorubicin-induced cardiotoxicity.
Wei J, Lan G, Zhang W, Ran W, Wei Y, Liu X, Zhang Y, Gong Q, Li H, Gao J
British journal of pharmacology 2025 Jun;182(11):2409-2425
British journal of pharmacology 2025 Jun;182(11):2409-2425
Precision targeted melanoma therapy via cuproptosis/chemodynamic and chemotherapy: An engineering MCHS-CuMOF nanodelivery system.
Zhang Y, Xie W, Li J, Liang Z, Zhou X, Tan Z, Wu Z, Lin J, Zhuo Y, Zou F, Wen B, Chen J, Cai S, Ye J, Liang Y, Lu J, Yang H, Zhong W, Yang R
Biomaterials advances 2025 Jun;171:214228
Biomaterials advances 2025 Jun;171:214228
Radiotherapy promotes cuproptosis and synergizes with cuproptosis inducers to overcome tumor radioresistance.
Lei G, Sun M, Cheng J, Ye R, Lu Z, Horbath A, Huo D, Wu S, Alapati A, Aggarwal S, Xu Z, Mao C, Yan Y, Yao J, Li Q, Chen X, Lee H, Zhuang L, Jiang D, Pataer A, Roth JA, Navin N, Koong AC, You MJ, Lin SH, Gan B
Cancer cell 2025 Jun 9;43(6):1076-1092.e5
Cancer cell 2025 Jun 9;43(6):1076-1092.e5
C5a/C5aR pathway blocking promoted CuS-mediated cancer therapy effect by inhibiting cuproptosis resistance.
Yang H, Deng B, Han X, Wang L, Zhao J, Zhao Y, Sun Z, Wang S, Liu G, Wu Y, Chen J
Journal for immunotherapy of cancer 2025 Jun 8;13(6)
Journal for immunotherapy of cancer 2025 Jun 8;13(6)
Modulation of copper homeostasis and cuproptosis by PDHA1 in acute myeloid leukemia.
Chen T, Wei N, Lv W, Qu L, Qu Q, Wu C, Ling Y, Liu H, Liu H
Discover oncology 2025 Jun 10;16(1):1044
Discover oncology 2025 Jun 10;16(1):1044
Increased CDKN2A expression correlates with resistance to platinum-based therapy and decreased infiltration of B lymphocytes in colon adenocarcinoma.
Gu R, Li S, Yu B, Gu J, Guan B, Wu H
Functional & integrative genomics 2025 Jul 3;25(1):144
Functional & integrative genomics 2025 Jul 3;25(1):144
Molecular function validation and prognostic value analysis of the cuproptosis-related gene ferredoxin 1 in papillary thyroid carcinoma.
He S, Peng W, Hu X, Chen Y
Scientific reports 2025 Jul 23;15(1):26845
Scientific reports 2025 Jul 23;15(1):26845
CuOTeDsP nanotherapeutics enhance cuproptosis-mediated immunotherapy by modulating cholesterol metabolism in bladder cancer.
Cai H, Xue P, Liu S, Ma Y, Zeng X, Yan S, Xu N
Journal of nanobiotechnology 2025 Jul 22;23(1):534
Journal of nanobiotechnology 2025 Jul 22;23(1):534
Exploiting mitochondrial dysfunction to overcome BRAF inhibitor resistance in advanced melanoma: the role of disulfiram as a copper ionophore.
Zhao B, Ban F, Li Y, Shi Q, Guo S, Yi X, Wang H, Gao T, Li C, Zhu G
Cell death & disease 2025 Jul 1;16(1):482
Cell death & disease 2025 Jul 1;16(1):482
Cupric Doping Hollow Prussian Blue Nanoplatform for Enhanced Cholesterol Depletion: a Promising Strategy for Breast Cancer Therapy and Metastasis Inhibition.
Yan S, Xue P, Sun Y, Bai T, Shao S, Zeng X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jan;12(3):e2409967
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jan;12(3):e2409967
A metal-organic framework functionalized CaO(2)-based cascade nanoreactor induces synergistic cuproptosis/ferroptosis and Ca(2+) overload-mediated mitochondrial damage for enhanced sono-chemodynamic immunotherapy.
Tang C, Liu K, Gao X, Kang H, Xie W, Chang J, Yin L, Kang J
Acta biomaterialia 2025 Jan 24;193:455-473
Acta biomaterialia 2025 Jan 24;193:455-473
p53 induces circFRMD4A to suppress cancer development through glycolytic reprogramming and cuproptosis.
Liao Q, Deng J, Tong J, Gan Y, Hong W, Dong H, Cao M, Xiong C, Chen Y, Xie B, Yang FY, Alifu A, Zhou GB, Huang S, Xiong J, Hao Q, Zhou X
Molecular cell 2025 Jan 2;85(1):132-149.e7
Molecular cell 2025 Jan 2;85(1):132-149.e7
Cuproptosis and Serine Metabolism Blockade Triggered by Copper-Based Prussian Blue Nanomedicine for Enhanced Tumor Therapy.
Ma Q, Gao S, Li C, Yao J, Xie Y, Jiang C, Yuan J, Fei K, Zhang P, Wang H, Li X
Small (Weinheim an der Bergstrasse, Germany) 2025 Feb;21(5):e2406942
Small (Weinheim an der Bergstrasse, Germany) 2025 Feb;21(5):e2406942
Modulation of the local angiotensin II: Suppression of ferroptosis and radiosensitivity in nasopharyngeal carcinoma via the HIF-1α-HILPDA axis.
Huang X, Lin K, Chen W, Zhang D, Khan M, Ye X, Wang B, Chen C, Tian Y, Yuan Y, Lin J
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2025 Feb;203:110686
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2025 Feb;203:110686
Glutathione Induced In Situ Activation of Dual-Locked Cuproptosis Nanoamplifier with Glycolysis Metabolism Inhibition to Boost Cancer Immunotherapy.
Wu X, Zhang S, Feng M, Sun H, Lan X, Liang W, Liu C, Li Y
Advanced healthcare materials 2025 Feb;14(4):e2403380
Advanced healthcare materials 2025 Feb;14(4):e2403380
UiO-66 MOFs-Based "Epi-Nano-Sonosensitizer" for Ultrasound-Driven Cascade Immunotherapy against B-Cell Lymphoma.
Wang Z, Han M, Wang Y, Wang N, Yang Y, Shao B, Miao Q, Shi Z, Yan F, Feng S
ACS nano 2025 Feb 18;19(6):6282-6298
ACS nano 2025 Feb 18;19(6):6282-6298
Regulating SLC7A11/GSH/GPX4 axis by glucose dyshomeostasis to simultaneously promote disulfidptosis, cuproptosis and ferroptosis.
Zhang M, Zheng H, Jin H, Zhu X, Liu S, Chen Y, Zhang H, Zhang S
Bioactive materials 2025 Dec;54:744-758
Bioactive materials 2025 Dec;54:744-758
Cu-doped dendritic biodegradable nanoplatforms for augmenting cuproptosis and tumor-starvation therapy through mitochondrial metabolic cascade modulation.
Shi H, Xie Z, Zhang J, Lu F, Luo H, Guo P, Jiang M, Weng Z, Luo X, Chen B, Huang H, Teng T
Materials today. Bio 2025 Dec;35:102477
Materials today. Bio 2025 Dec;35:102477
Biodegradable Cu-based sonozymes for tumor-specific cuproptosis-enhanced sono-immunotherapy through activating cGAS-STING pathway and sensitizing immune checkpoint blockade.
Wu Y, Xu S, Cai J, Hu J, Pan D, Geng B, Gao W, Wu Y
Materials today. Bio 2025 Dec;35:102397
Materials today. Bio 2025 Dec;35:102397
Clinically friendly smart hydrogel boosts cuproptosis and PD-L1 upregulation to enhance anti-tumor immunotherapy.
Fu B, Li G, Yao Y, Zhang M, Zhong Y, Wang X, Chen Y, Liang W, Wang Y, Lin H, Zhang Y, Du Q, Xu Z, Cui H, Shi L, Chen X, Zhang J
Materials today. Bio 2025 Dec;35:102268
Materials today. Bio 2025 Dec;35:102268
Carrier-Free Self-Assembled Nanoparticles for Triple-Amplified Tumor Chemodynamic Therapy and Cuproptosis Induction.
Cheng J, Chen S, Geng M, Wei X, Meng S, Gong L, Chen K, Wang Z, Liu Y, Li X, Li A, Li X, Dai L
Advanced healthcare materials 2025 Dec;14(32):e2501507
Advanced healthcare materials 2025 Dec;14(32):e2501507
Disruption of NF-κB-Mediated Copper Homeostasis Sensitizes Breast Cancer to Cuproptosis.
Zhang X, Su Y, Yang W, Song Z, Sun Z, Wu X, Chen J, Gao B, Wang Z, Wang L, Jiang Q, Bu L, Li J, Lin Y, Xie W, Li J, Guo J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(47):e06201
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(47):e06201
Functional nano-nucleic acid platform promotes copper-induced gastric cancer cell death.
Zhang H, Ding B, Kou Q
RSC advances 2025 Dec 8;15(57):49643-49651
RSC advances 2025 Dec 8;15(57):49643-49651
Targeting multiple genetic defects of mitochondrial diseases with a single bacterial lipoate protein ligase.
Hu Z, Yu J, Liu Z, Jiang M, Zeng AP
Science advances 2025 Dec 5;11(49):eaea8481
Science advances 2025 Dec 5;11(49):eaea8481
LRPPRC-Driven Oxidative Phosphorylation Is Associated with Elesclomol-Induced Cuproptosis in Ovarian Cancer.
Wu Y, Zhang W, Jiang S, Liu S, Su J, Sun L
International journal of molecular sciences 2025 Dec 31;27(1)
International journal of molecular sciences 2025 Dec 31;27(1)
Vitisin A inhibits liver fibrosis by promoting Nrf2/HO-1 pathway and inhibiting Cuproptosis.
Ding S, Hu D, Pan Y, Wang J, Wang L
Scientific reports 2025 Dec 19;15(1):44186
Scientific reports 2025 Dec 19;15(1):44186
TRIM14 Regulation of Copper Homeostasis and Cuproptosis: A New Strategy to Overcome Chemoresistance in Glioblastoma.
Wang J, Zhang E, Chen S, Wang H, Huang Y, Lan W
Biomedicines 2025 Dec 15;13(12)
Biomedicines 2025 Dec 15;13(12)
Copper ionophore elicits calpain-dependent paraptosis coincident with proteotoxic stress.
Sae-Fung A, Fadeel B
Cell communication and signaling : CCS 2025 Dec 12;24(1):47
Cell communication and signaling : CCS 2025 Dec 12;24(1):47
Melanoma MHC-I-membrane-encapsulated Cu@ferrihydrite induces ferroptosis/cuproptosis and systematic immunity against tumor.
Yang R, Deng F, Gao Z, Li X, Huangfu S, Tian Q, Wang H, Liu H, Wang X, Chen Y, Yang Y, Cheng G, Zhang L
Journal of controlled release : official journal of the Controlled Release Society 2025 Dec 10;388(Pt 1):114281
Journal of controlled release : official journal of the Controlled Release Society 2025 Dec 10;388(Pt 1):114281
Dapagliflozin Suppressed Cuproptosis and Myocardial Fibrosis in Myocardial Infarction Through HIF-1α/TGF-β Pathway.
Zhang YZ, Lin TT, Fan SM, Wu YQ
Current medical science 2025 Aug;45(4):831-840
Current medical science 2025 Aug;45(4):831-840
High-Efficiency Carriers' Separation Strategy Based Ultrasmall-Bandgap CuWO(4) Sono-Enhances GSH Antagonism for Cuproptosis Cascade Immunotherapy.
Zhu L, Guo Z, Luo Y, Huang H, Zhang K, Duan B, Peng R, Yao H, Liang C, Wang K
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(29):e00576
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(29):e00576
Spinal cord ischemia reperfusion injury induces cuproptosis in neurons.
Xie L, Wu H, He Q, Shi W, Xiao X, Yu T
Cell & bioscience 2025 Aug 21;15(1):120
Cell & bioscience 2025 Aug 21;15(1):120
Copper-Induced Cuproptosis and Immunogenic Cell Death Synergize with Radiotherapy and PD-1 Blockade in Osteosarcoma.
Yao J, Chen P, Xie D, Chen J, Lin X, Xu Y
ACS applied materials & interfaces 2025 Aug 20;17(33):46635-46650
ACS applied materials & interfaces 2025 Aug 20;17(33):46635-46650
Cu(OH)(2) nanopesticide induced liver dysfunction in mice by targeting lipoylated tricarboxylic acid cycle proteins via ferredoxin 1.
Ren Z, Ren M, Ling W, Ren D, Liang J, Cai Y, Wang X, Wang S, Duan Y, Ku T, Ning X, Sang N
Journal of hazardous materials 2025 Aug 15;494:138403
Journal of hazardous materials 2025 Aug 15;494:138403
Engineering M2 macrophage-derived exosomes modulate activated T cell cuproptosis to promote immune tolerance in rheumatoid arthritis.
Wu G, Su T, Zhou P, Tang R, Zhu X, Wang J, Chao M, Fan L, Yan H, Ye P, Yu D, Gao F, Chen H
Biomaterials 2025 Apr;315:122943
Biomaterials 2025 Apr;315:122943
Multifunctional porous organic polymer-based hybrid nanoparticles for sonodynamically enhanced cuproptosis and synergistic tumor therapy.
Li M, Liu Z, Peng D, Liu Y, Cheng L, Chen B, Liu J
Acta biomaterialia 2025 Apr;196:350-363
Acta biomaterialia 2025 Apr;196:350-363
Cancer-associated fibroblasts promote oral squamous cell carcinoma progression by targeting ATP7A via exosome-mediated paracrine miR-148b-3p.
Zhang S, Liu X, Zhang J, Chen K, Li W, Yao Y, Wang A, Hou J
Cellular signalling 2025 Apr;128:111631
Cellular signalling 2025 Apr;128:111631
Chlorophyllin exerts synergistic anti-tumor effect with gemcitabine in pancreatic cancer by inducing cuproptosis.
Ren J, Su T, Ding J, Chen F, Mo J, Li J, Wang Z, Han L, Wu Z, Wu S
Molecular medicine (Cambridge, Mass.) 2025 Apr 4;31(1):126
Molecular medicine (Cambridge, Mass.) 2025 Apr 4;31(1):126
Impact of diabetes and metformin on cuproptosis and ferroptosis in breast cancer patients: an immunohistochemical analysis.
Li C, Chen T, Li Y, Zhou C, Du J, Li X, Tang C, Ma C, Deng N, Cui H
Discover oncology 2025 Apr 29;16(1):634
Discover oncology 2025 Apr 29;16(1):634
Copper-mediated SEC14L3 promotes cuproptosis to inhibit hepatocellular carcinoma growth via ERK/YY1/FDX1 axis.
Wu C, Long L, Wang M, Shen L, Hu J, Tang H, Feng S, Liu X, Shi Y, Tang S, Chen Y
Communications biology 2025 Apr 24;8(1):658
Communications biology 2025 Apr 24;8(1):658
o8G-modified circKIAA1797 promotes lung cancer development by inhibiting cuproptosis.
Xu H, Zhao Q, Cai D, Chen X, Zhou X, Gao Y, Wu J, Yuan S, Li D, Zhang R, Peng W, Li G, Nan A
Journal of experimental & clinical cancer research : CR 2025 Apr 2;44(1):110
Journal of experimental & clinical cancer research : CR 2025 Apr 2;44(1):110
Endoplasmic reticulum stress related super-enhancers suppress cuproptosis via glycolysis reprogramming in lung adenocarcinoma.
Gu Y, Wang H, Xue W, Zhu L, Fu C, Zhang W, Mu G, Xia Y, Wei K, Wang J
Cell death & disease 2025 Apr 19;16(1):316
Cell death & disease 2025 Apr 19;16(1):316
Cuproptosis-related lncRNAs emerge as a novel signature for predicting prognosis in prostate carcinoma and functional experimental validation.
Lu Y, Wu J, Li X, Leng Q, Tan J, Huang H, Zhong R, Chen Z, Zhang Y
Frontiers in immunology 2024;15:1471198
Frontiers in immunology 2024;15:1471198
FDX2, an iron-sulfur cluster assembly factor, is essential to prevent cellular senescence, apoptosis or ferroptosis of ovarian cancer cells.
Miyahara S, Ohuchi M, Nomura M, Hashimoto E, Soga T, Saito R, Hayashi K, Sato T, Saito M, Yamashita Y, Shimada M, Yaegashi N, Yamada H, Tanuma N
The Journal of biological chemistry 2024 Sep;300(9):107678
The Journal of biological chemistry 2024 Sep;300(9):107678
GSH exhaustion via inhibition of xCT-GSH-GPX4 pathway synergistically enhanced DSF/Cu-induced cuproptosis in myelodysplastic syndromes.
Li H, Li Y, Yu Y, Ren X, Yang C, Jin W, Li K, Zhou Y, Wu C, Shen Y, Hu W, Liu Y, Yu L, Tong X, Du J, Wang Y
Free radical biology & medicine 2024 Sep;222:130-148
Free radical biology & medicine 2024 Sep;222:130-148
SP1/CTR1-mediated oxidative stress-induced cuproptosis in intervertebral disc degeneration.
Chen X, Li K, Xiao Y, Wu W, Lin H, Qing X, Tian S, Liu S, Feng S, Wang B, Shao Z, Peng Y
BioFactors (Oxford, England) 2024 Sep-Oct;50(5):1009-1023
BioFactors (Oxford, England) 2024 Sep-Oct;50(5):1009-1023
Identification of diagnostic signature and immune infiltration for ischemic cardiomyopathy based on cuproptosis-related genes through bioinformatics analysis and experimental validation.
Tan X, Xu S, Zeng Y, Qin Z, Yu F, Jiang H, Xu H, Li X, Wang X, Zhang G, Ma B, Zhang T, Fan J, Bo X, Kang P, Tang J, Fan H, Zhou Y
International immunopharmacology 2024 Sep 10;138:112574
International immunopharmacology 2024 Sep 10;138:112574
Novel Insights Into DLAT's Role in Alzheimer's Disease-Related Copper Toxicity Through Microglial Exosome Dynamics.
Ma X, Sun Y, Li C, Wang M, Zang Q, Zhang X, Wang F, Niu Y, Hua J
CNS neuroscience & therapeutics 2024 Oct;30(10):e70064
CNS neuroscience & therapeutics 2024 Oct;30(10):e70064
CuO Nanozymes Catalyze Cysteine and Glutathione Depletion Induced Ferroptosis and Cuproptosis for Synergistic Tumor Therapy.
Bai J, Zhang X, Zhao Z, Sun S, Cheng W, Yu H, Chang X, Wang B
Small (Weinheim an der Bergstrasse, Germany) 2024 Oct;20(40):e2400326
Small (Weinheim an der Bergstrasse, Germany) 2024 Oct;20(40):e2400326
Role of cuproptosis in mediating the severity of experimental malaria-associated acute lung injury/acute respiratory distress syndrome.
Hou X, Zhou T, Wang Q, Chen P, Zhang M, Wu L, Liu W, Jin X, Liu Z, Li H, Huang B
Parasites & vectors 2024 Oct 19;17(1):433
Parasites & vectors 2024 Oct 19;17(1):433
Multifunctional Copper-Phenolic Nanopills Achieve Comprehensive Polyamines Depletion to Provoke Enhanced Pyroptosis and Cuproptosis for Cancer Immunotherapy.
Zhu G, Xie Y, Wang J, Wang M, Qian Y, Sun Q, Dai Y, Li C
Advanced materials (Deerfield Beach, Fla.) 2024 Nov;36(45):e2409066
Advanced materials (Deerfield Beach, Fla.) 2024 Nov;36(45):e2409066
CircSpna2 attenuates cuproptosis by mediating ubiquitin ligase Keap1 to regulate the Nrf2-Atp7b signalling axis in depression after traumatic brain injury in a mouse model.
Du M, Fu J, Zhang J, Zhu Z, Huang X, Tan W, Liu L, Huang Z, Liu X, Tan Q, Liao Z, Cheng Y
Clinical and translational medicine 2024 Nov;14(11):e70100
Clinical and translational medicine 2024 Nov;14(11):e70100
Three Birds with One Stone: Copper Ions Assisted Synergistic Cuproptosis/Chemodynamic/Photothermal Therapy by a Three-Pronged Approach.
Chen M, Xu C, Wang C, Huang N, Bian Z, Xiao Y, Ruan J, Sun F, Shi S
Advanced healthcare materials 2024 Nov;13(29):e2401567
Advanced healthcare materials 2024 Nov;13(29):e2401567
Copper-Based Composites Nanoparticles Improve Triple-Negative Breast Cancer Treatment with Induction of Apoptosis-Cuproptosis and Immune Activation.
Wang N, Liu Y, Peng D, Zhang Q, Zhang Z, Xu L, Yin L, Zhao X, Lu Z, Peng J
Advanced healthcare materials 2024 Nov;13(28):e2401646
Advanced healthcare materials 2024 Nov;13(28):e2401646
Rhomboid-like 2 correlated with TME infiltration inhibits cuproptosis-related genes and drives malignant phenotype in clear cell renal cell carcinoma.
Che Z, Jin W, Wu Y, Li H, Liang P
Scientific reports 2024 Nov 7;14(1):27053
Scientific reports 2024 Nov 7;14(1):27053
Ferredoxin 1: a gatekeeper in halting lung adenocarcinoma progression through activation of the GPRIN2 signaling pathway.
Liu M, Wu S, Wu H, Zhou Y, Zhang X, Zhu D, Jiang J
Journal of translational medicine 2024 May 27;22(1):510
Journal of translational medicine 2024 May 27;22(1):510
MUC20 regulated by extrachromosomal circular DNA attenuates proteasome inhibitor resistance of multiple myeloma by modulating cuproptosis.
Wang X, Shi Y, Shi H, Liu X, Liao A, Liu Z, Orlowski RZ, Zhang R, Wang H
Journal of experimental & clinical cancer research : CR 2024 Mar 5;43(1):68
Journal of experimental & clinical cancer research : CR 2024 Mar 5;43(1):68
A cuproptosis-related gene expression signature predicting clinical prognosis and immune responses in intrahepatic cholangiocarcinoma detected by single-cell RNA sequence analysis.
Ren H, Liu C, Zhang C, Wu H, Zhang J, Wang Z, Chen L, Wang H, Shao C, Zhou L
Cancer cell international 2024 Mar 2;24(1):92
Cancer cell international 2024 Mar 2;24(1):92
Integrated profiling identifies ferredoxin 1 as an immune-related biomarker of malignant phenotype in glioma.
Xie D, Huang H, Guo Y, Jiang Z, Kuang Y, Huang H, Liu W, Wang L, Xin Z, Wang B, Ren C, Jiang X
Heliyon 2024 Mar 15;10(5):e26976
Heliyon 2024 Mar 15;10(5):e26976
Clinical features and molecular landscape of cuproptosis signature-related molecular subtype in gastric cancer.
Chong W, Ren H, Chen H, Xu K, Zhu X, Liu Y, Sang Y, Li H, Liu J, Ye C, Shang L, Jing C, Li L
iMeta 2024 Jun;3(3):e190
iMeta 2024 Jun;3(3):e190
Elesclomol-copper synergizes with imidazole ketone erastin by promoting cuproptosis and ferroptosis in myelodysplastic syndromes.
Gao Y, Jin F, Zhang P, Zheng C, Zheng X, Xie J, Lu Y, Tong X, Du J, Zhang J, Wang Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jun;175:116727
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jun;175:116727
Mitochondrial-Targeted Copper Delivery for Cuproptosis-Based Synergistic Cancer Therapy.
Deng J, Zhuang H, Shao S, Zeng X, Xue P, Bai T, Wang X, Shangguan S, Chen Y, Yan S, Huang W
Advanced healthcare materials 2024 Jul;13(18):e2304522
Advanced healthcare materials 2024 Jul;13(18):e2304522
Molecular characterization and clinical relevance of metabolic signature subtypes in gastric cancer.
Chen H, Jing C, Shang L, Zhu X, Zhang R, Liu Y, Wang M, Xu K, Ma T, Jing H, Wang Z, Li X, Chong W, Li L
Cell reports 2024 Jul 23;43(7):114424
Cell reports 2024 Jul 23;43(7):114424
Potential of lncRNAs to regulate cuproptosis in hepatocellular carcinoma: Establishment and validation of a novel risk model.
He J, Li W, Zhao W, Shen H, Chang Y, Liu B, He Q, Yu H, Wang Y, Shi L, Cai X
Heliyon 2024 Jan 30;10(2):e24453
Heliyon 2024 Jan 30;10(2):e24453
Inhibiting the compensatory elevation of xCT collaborates with disulfiram/copper-induced GSH consumption for cascade ferroptosis and cuproptosis.
Zhang P, Zhou C, Ren X, Jing Q, Gao Y, Yang C, Shen Y, Zhou Y, Hu W, Jin F, Xu H, Yu L, Liu Y, Tong X, Li Y, Wang Y, Du J
Redox biology 2024 Feb;69:103007
Redox biology 2024 Feb;69:103007
Combination of the cuproptosis inducer disulfiram and anti‑PD‑L1 abolishes NSCLC resistance by ATP7B to regulate the HIF‑1 signaling pathway.
Li P, Sun Q, Bai S, Wang H, Zhao L
International journal of molecular medicine 2024 Feb;53(2)
International journal of molecular medicine 2024 Feb;53(2)
Deep learning enables the discovery of a novel cuproptosis-inducing molecule for the inhibition of hepatocellular carcinoma.
Yang F, Jia L, Zhou HC, Huang JN, Hou MY, Liu FT, Prabhu N, Li ZJ, Yang CB, Zou C, Nordlund P, Wang JG, Dai LY
Acta pharmacologica Sinica 2024 Feb;45(2):391-404
Acta pharmacologica Sinica 2024 Feb;45(2):391-404
Copper-coordinated nanoassemblies based on photosensitizer-chemo prodrugs and checkpoint inhibitors for enhanced apoptosis-cuproptosis and immunotherapy.
Liang W, Han C, Zhang D, Liu C, Zhu M, Xu F, Fang C, Zhang S, Liu C, Li Y
Acta biomaterialia 2024 Feb;175:341-352
Acta biomaterialia 2024 Feb;175:341-352
Protein phosphatase 1 regulatory subunit 15 A promotes translation initiation and induces G2M phase arrest during cuproptosis in cancers.
Liu C, Chen L, Cong Y, Cheng L, Shuai Y, Lv F, Chen K, Song Y, Xing Y
Cell death & disease 2024 Feb 16;15(2):149
Cell death & disease 2024 Feb 16;15(2):149
Novel immune cross-talk between inflammatory bowel disease and IgA nephropathy.
Yan Q, Zhao Z, Liu D, Li J, Pan S, Duan J, Liu Z
Renal failure 2024 Dec;46(1):2337288
Renal failure 2024 Dec;46(1):2337288
Sirtuin 7 ameliorates cuproptosis, myocardial remodeling and heart dysfunction in hypertension through the modulation of YAP/ATP7A signaling.
Chen YF, Qi RQ, Song JW, Wang SY, Dong ZJ, Chen YH, Liu Y, Zhou XY, Li J, Liu XY, Zhong JC
Apoptosis : an international journal on programmed cell death 2024 Dec;29(11-12):2161-2182
Apoptosis : an international journal on programmed cell death 2024 Dec;29(11-12):2161-2182
Cuprorivaite microspheres inhibit cuproptosis and oxidative stress in osteoarthritis via Wnt/β-catenin pathway.
Li B, Jiang T, Wang J, Ge H, Zhang Y, Li T, Wang C, Wang W
Materials today. Bio 2024 Dec;29:101300
Materials today. Bio 2024 Dec;29:101300
Synergistic enhancement of low-dose radiation therapy via cuproptosis and metabolic reprogramming for radiosensitization in in situ hepatocellular carcinoma.
Shao N, Yang Y, Hu G, Luo Q, Cheng N, Chen J, Huang Y, Zhang H, Luo L, Xiao Z
Journal of nanobiotechnology 2024 Dec 19;22(1):772
Journal of nanobiotechnology 2024 Dec 19;22(1):772
Curcuminoid PBPD induces cuproptosis and endoplasmic reticulum stress in cervical cancer via the Notch1/RBP-J/NRF2/FDX1 pathway.
Zhang MJ, Shi M, Yu Y, Ou R, Ge RS, Duan P
Molecular carcinogenesis 2024 Aug;63(8):1449-1466
Molecular carcinogenesis 2024 Aug;63(8):1449-1466
Copper Homeostasis Based on Cuproptosis-Related Signature Optimizes Molecular Subtyping and Treatment of Glioma.
Zhang S, Yu H, Sun S, Fan X, Bi W, Li S, Wang W, Fang Z, Chen X
Molecular neurobiology 2024 Aug;61(8):4962-4975
Molecular neurobiology 2024 Aug;61(8):4962-4975
Injectable Hydrogel-Encapsulating Pickering Emulsion for Overcoming Lenvatinib-Resistant Hepatocellular Carcinoma via Cuproptosis Induction and Stemness Inhibition.
Li X, Tang C, Ye H, Fang C
Polymers 2024 Aug 26;16(17)
Polymers 2024 Aug 26;16(17)
Eupalinolide B suppresses pancreatic cancer by ROS generation and potential cuproptosis.
Huang Q, Yang J, Zhang J, Yao L, Jiang B, Du S, Li F, Peng Q, Qin L, Wang Y, Qi L
iScience 2024 Aug 16;27(8):110496
iScience 2024 Aug 16;27(8):110496
Cellular Trojan Horse initiates bimetallic Fe-Cu MOF-mediated synergistic cuproptosis and ferroptosis against malignancies.
Chen K, Zhou A, Zhou X, He J, Xu Y, Ning X
Science advances 2024 Apr 12;10(15):eadk3201
Science advances 2024 Apr 12;10(15):eadk3201
Identification of core cuprotosis-correlated biomarkers in abdominal aortic aneurysm immune microenvironment based on bioinformatics.
Hu J, Xue S, Xu Z, Wu Z, Xu X, Wang X, Liu G, Lu X, Li B, Liu X
Frontiers in immunology 2023;14:1138126
Frontiers in immunology 2023;14:1138126
Identification of cuproptosis-related subtypes and the development of a prognostic model in glioma.
Wu Z, Li W, Zhu H, Li X, Zhou Y, Chen Q, Huang H, Zhang W, Jiang X, Ren C
Frontiers in genetics 2023;14:1124439
Frontiers in genetics 2023;14:1124439
Identification of a cuproptosis and copper metabolism gene-related lncRNAs prognostic signature associated with clinical and immunological characteristics of hepatocellular carcinoma.
Yuan W, Xiao JH, Zhang JS, Mao BL, Wang PZ, Wang BL
Frontiers in oncology 2023;13:1153353
Frontiers in oncology 2023;13:1153353
ITGB1-mediated molecular landscape and cuproptosis phenotype induced the worse prognosis in diffuse gastric cancer.
Zhu X, Chen H, Li H, Ren H, Ye C, Xu K, Liu J, Du F, Zhang Z, Liu Y, Xie X, Wang M, Ma T, Chong W, Shang L, Li L
Frontiers in oncology 2023;13:1115510
Frontiers in oncology 2023;13:1115510
Lipoylation is dependent on the ferredoxin FDX1 and dispensable under hypoxia in human cells.
Joshi PR, Sadre S, Guo XA, McCoy JG, Mootha VK
The Journal of biological chemistry 2023 Sep;299(9):105075
The Journal of biological chemistry 2023 Sep;299(9):105075
Evaluation the role of cuproptosis-related genes in the pathogenesis, diagnosis and molecular subtypes identification of atherosclerosis.
Wang M, Cheng L, Xiang Q, Gao Z, Ding Y, Xie H, Chen X, Yu P, Shen L
Heliyon 2023 Oct;9(10):e21158
Heliyon 2023 Oct;9(10):e21158
Lactylation of METTL16 promotes cuproptosis via m(6)A-modification on FDX1 mRNA in gastric cancer.
Sun L, Zhang Y, Yang B, Sun S, Zhang P, Luo Z, Feng T, Cui Z, Zhu T, Li Y, Qiu Z, Fan G, Huang C
Nature communications 2023 Oct 20;14(1):6523
Nature communications 2023 Oct 20;14(1):6523
Targeting the TCA cycle through cuproptosis confers synthetic lethality on ARID1A-deficient hepatocellular carcinoma.
Xing T, Li L, Chen Y, Ju G, Li G, Zhu X, Ren Y, Zhao J, Cheng Z, Li Y, Xu D, Liang J
Cell reports. Medicine 2023 Nov 21;4(11):101264
Cell reports. Medicine 2023 Nov 21;4(11):101264
4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to promote cuproptosis in colorectal cancer.
Yang W, Wang Y, Huang Y, Yu J, Wang T, Li C, Yang L, Zhang P, Shi L, Yin Y, Tao K, Li R
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Mar;159:114301
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Mar;159:114301
FDX1-dependent and independent mechanisms of elesclomol-mediated intracellular copper delivery.
Zulkifli M, Spelbring AN, Zhang Y, Soma S, Chen S, Li L, Le T, Shanbhag V, Petris MJ, Chen TY, Ralle M, Barondeau DP, Gohil VM
Proceedings of the National Academy of Sciences of the United States of America 2023 Mar 7;120(10):e2216722120
Proceedings of the National Academy of Sciences of the United States of America 2023 Mar 7;120(10):e2216722120
A novel cuproptosis-related gene signature to predict prognosis in Glioma.
Zhang M, Liu X, Wang D, Ruan X, Wang P, Liu L, Xue Y
BMC cancer 2023 Mar 13;23(1):237
BMC cancer 2023 Mar 13;23(1):237
Expression of Ferredoxin1 in cisplatin‑resistant ovarian cancer cells confers their resistance against ferroptosis induced by cisplatin.
Takahashi R, Kamizaki K, Yamanaka K, Terai Y, Minami Y
Oncology reports 2023 Jun;49(6)
Oncology reports 2023 Jun;49(6)
Critical role of antioxidant programs in enzalutamide-resistant prostate cancer.
Blatt EB, Parra K, Neeb A, Buroni L, Bogdan D, Yuan W, Gao Y, Gilbreath C, Paschalis A, Carreira S, DeBerardinis RJ, Mani RS, de Bono JS, Raj GV
Oncogene 2023 Jul;42(30):2347-2359
Oncogene 2023 Jul;42(30):2347-2359
Confirmation of the predictive function of cuproptosis-related gene FDX1 in clear cell renal carcinoma using qRT-PCR and western blotting.
Cai C, Zhou K, Jing J, Ren Y, Weng G, Cen D, Wang X, Huang S
Aging 2023 Jul 10;15(13):6117-6134
Aging 2023 Jul 10;15(13):6117-6134
Sinapic and ferulic acid phenethyl esters increase the expression of steroidogenic genes in MA-10 tumor Leydig cells.
Basque A, Touaibia M, Martin LJ
Toxicology in vitro : an international journal published in association with BIBRA 2023 Feb;86:105505
Toxicology in vitro : an international journal published in association with BIBRA 2023 Feb;86:105505
SP1 impacts the primordial to primary follicle transition by regulating cholesterol metabolism in granulosa cells.
Zhou J, Lin L, Cai H, Liu L, Wang H, Zhang J, Xia G, Wang J, Wang F, Wang C
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Feb;37(2):e22767
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Feb;37(2):e22767
Glutathione ameliorates the meiotic defects of copper exposed ovine oocytes via inhibiting the mitochondrial dysfunctions.
Ren J, Wang B, Li L, Li S, Ma Y, Su L, Liu G, Liu Y, Dai Y
Ecotoxicology and environmental safety 2023 Feb;251:114530
Ecotoxicology and environmental safety 2023 Feb;251:114530
Bioinformatics analysis and experimental validation of cuproptosis-related lncRNA LINC02154 in clear cell renal cell carcinoma.
Shen J, Wang L, Bi J
BMC cancer 2023 Feb 16;23(1):160
BMC cancer 2023 Feb 16;23(1):160
Dexmedetomidine enables copper homeostasis in cerebral ischemia/reperfusion via ferredoxin 1.
Guo Q, Ma M, Yu H, Han Y, Zhang D
Annals of medicine 2023 Dec;55(1):2209735
Annals of medicine 2023 Dec;55(1):2209735
Integrated bioinformatics and experiment revealed that cuproptosis is the potential common pathogenesis of three kinds of primary cardiomyopathy.
Wang M, Xu X, Li J, Gao Z, Ding Y, Chen X, Xiang Q, Shen L
Aging 2023 Dec 11;15(23):14210-14241
Aging 2023 Dec 11;15(23):14210-14241
FDX1 Is Required for the Biogenesis of Mitochondrial Cytochrome c Oxidase in Mammalian Cells.
Zulkifli M, Okonkwo AU, Gohil VM
Journal of molecular biology 2023 Dec 1;435(23):168317
Journal of molecular biology 2023 Dec 1;435(23):168317
Comprehensive analysis of cuproptosis-related immune biomarker signature to enhance prognostic accuracy in gastric cancer.
Li J, Yu T, Sun J, Zeng Z, Liu Z, Ma M, Zheng Z, He Y, Kang W
Aging 2023 Apr 7;15(7):2772-2796
Aging 2023 Apr 7;15(7):2772-2796
A Novel Cuprotosis-Related Gene FDX1 Signature for Overall Survival Prediction in Clear Cell Renal Cell Carcinoma Patients.
Zhang WT, Gong YM, Zhang CY, Pan JS, Huang T, Li YX
BioMed research international 2022;2022:9196540
BioMed research international 2022;2022:9196540
FDX1 expression predicts favourable prognosis in clear cell renal cell carcinoma identified by bioinformatics and tissue microarray analysis.
Huang X, Wang T, Ye J, Feng H, Zhang X, Ma X, Wang B, Huang Y, Zhang X
Frontiers in genetics 2022;13:994741
Frontiers in genetics 2022;13:994741
Multi-omics pan-cancer study of cuproptosis core gene FDX1 and its role in kidney renal clear cell carcinoma.
Xu J, Hu Z, Cao H, Zhang H, Luo P, Zhang J, Wang X, Cheng Q, Li J
Frontiers in immunology 2022;13:981764
Frontiers in immunology 2022;13:981764
Ferredoxin 1 is a cuproptosis-key gene responsible for tumor immunity and drug sensitivity: A pan-cancer analysis.
Yang L, Zhang Y, Wang Y, Jiang P, Liu F, Feng N
Frontiers in pharmacology 2022;13:938134
Frontiers in pharmacology 2022;13:938134
A novel signature to guide osteosarcoma prognosis and immune microenvironment: Cuproptosis-related lncRNA.
Yang M, Zheng H, Xu K, Yuan Q, Aihaiti Y, Cai Y, Xu P
Frontiers in immunology 2022;13:919231
Frontiers in immunology 2022;13:919231
Role of cuproptosis-related gene in lung adenocarcinoma.
Liu Y, Lin W, Yang Y, Shao J, Zhao H, Wang G, Shen A
Frontiers in oncology 2022;12:1080985
Frontiers in oncology 2022;12:1080985
Establishment and experimental validation of a novel cuproptosis-related gene signature for prognostic implication in cholangiocarcinoma.
Chen J, Yu X, Tong H, Tang C, Tang Z
Frontiers in oncology 2022;12:1054063
Frontiers in oncology 2022;12:1054063
Cuproptosis-Related MiR-21-5p/FDX1 Axis in Clear Cell Renal Cell Carcinoma and Its Potential Impact on Tumor Microenvironment.
Xie M, Cheng B, Yu S, He Y, Cao Y, Zhou T, Han K, Dai R, Wang R
Cells 2022 Dec 31;12(1)
Cells 2022 Dec 31;12(1)
SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells.
Wang Y, Yen FS, Zhu XG, Timson RC, Weber R, Xing C, Liu Y, Allwein B, Luo H, Yeh HW, Heissel S, Unlu G, Gamazon ER, Kharas MG, Hite R, Birsoy K
Nature 2021 Nov;599(7883):136-140
Nature 2021 Nov;599(7883):136-140
Maintaining Iron Homeostasis Is the Key Role of Lysosomal Acidity for Cell Proliferation.
Weber RA, Yen FS, Nicholson SPV, Alwaseem H, Bayraktar EC, Alam M, Timson RC, La K, Abu-Remaileh M, Molina H, Birsoy K
Molecular cell 2020 Feb 6;77(3):645-655.e7
Molecular cell 2020 Feb 6;77(3):645-655.e7
Mitochondrial metabolism promotes adaptation to proteotoxic stress.
Tsvetkov P, Detappe A, Cai K, Keys HR, Brune Z, Ying W, Thiru P, Reidy M, Kugener G, Rossen J, Kocak M, Kory N, Tsherniak A, Santagata S, Whitesell L, Ghobrial IM, Markley JL, Lindquist S, Golub TR
Nature chemical biology 2019 Jul;15(7):681-689
Nature chemical biology 2019 Jul;15(7):681-689
Genomic expression profiles in cumulus cells derived from germinal vesicle and MII mouse oocytes.
Shao L, Chian RC, Xu Y, Yan Z, Zhang Y, Gao C, Gao L, Liu J, Cui Y
Reproduction, fertility, and development 2016 Sep 15;28(11):1798-1809
Reproduction, fertility, and development 2016 Sep 15;28(11):1798-1809
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HepG2 cells were subjected to SDS PAGE followed by western blot with 12592-1-AP(FDX1 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human kidney using 12592-1-AP(FDX1 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The FDX1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human FDX1. This antibody recognizes human,mouse,rat antigen. The FDX1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
