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ImmunocytochemistryAntibody data
- Antibody Data
- Antigen structure
- References [11]
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- Validations
- Western blot [1]
- Immunohistochemistry [3]
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- Product number
- NB100-1919 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NB100-1919, RRID:AB_2127207
- Product name
- Rabbit Polyclonal Mitofilin Antibody
- Antibody type
- Polyclonal
- Description
- Unpurified.
- Reactivity
- Human, Mouse, Rat, Canine, Feline, Simian
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 0.1 ml
- Storage
- Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Submitted references Inhibition of proteasome rescues a pathogenic variant of respiratory chain assembly factor COA7.
Membrane association but not identity is required for LRRK2 activation and phosphorylation of Rab GTPases.
Acylglycerol Kinase Mutated in Sengers Syndrome Is a Subunit of the TIM22 Protein Translocase in Mitochondria.
Desmin and αB-crystallin interplay in the maintenance of mitochondrial homeostasis and cardiomyocyte survival.
Ubiquitin-like modifier FAT10 attenuates RIG-I mediated antiviral signaling by segregating activated RIG-I from its signaling platform.
The presence of disulfide bonds reveals an evolutionarily conserved mechanism involved in mitochondrial protein translocase assembly.
p38 MAP kinase-dependent phosphorylation of the Gp78 E3 ubiquitin ligase controls ER-mitochondria association and mitochondria motility.
Disrupted-in-schizophrenia-1 (DISC1) Regulates Endoplasmic Reticulum Calcium Dynamics.
The mitochondrial citrate transporter, CIC, is essential for mitochondrial homeostasis.
Mitofilin regulates cytochrome c release during apoptosis by controlling mitochondrial cristae remodeling.
Molecular characterization of mitofilin (HMP), a mitochondria-associated protein with predicted coiled coil and intermembrane space targeting domains.
Mohanraj K, Wasilewski M, Benincá C, Cysewski D, Poznanski J, Sakowska P, Bugajska Z, Deckers M, Dennerlein S, Fernandez-Vizarra E, Rehling P, Dadlez M, Zeviani M, Chacinska A
EMBO molecular medicine 2019 May;11(5)
EMBO molecular medicine 2019 May;11(5)
Membrane association but not identity is required for LRRK2 activation and phosphorylation of Rab GTPases.
Gomez RC, Wawro P, Lis P, Alessi DR, Pfeffer SR
The Journal of cell biology 2019 Dec 2;218(12):4157-4170
The Journal of cell biology 2019 Dec 2;218(12):4157-4170
Acylglycerol Kinase Mutated in Sengers Syndrome Is a Subunit of the TIM22 Protein Translocase in Mitochondria.
Vukotic M, Nolte H, König T, Saita S, Ananjew M, Krüger M, Tatsuta T, Langer T
Molecular cell 2017 Aug 3;67(3):471-483.e7
Molecular cell 2017 Aug 3;67(3):471-483.e7
Desmin and αB-crystallin interplay in the maintenance of mitochondrial homeostasis and cardiomyocyte survival.
Diokmetzidou A, Soumaka E, Kloukina I, Tsikitis M, Makridakis M, Varela A, Davos CH, Georgopoulos S, Anesti V, Vlahou A, Capetanaki Y
Journal of cell science 2016 Oct 15;129(20):3705-3720
Journal of cell science 2016 Oct 15;129(20):3705-3720
Ubiquitin-like modifier FAT10 attenuates RIG-I mediated antiviral signaling by segregating activated RIG-I from its signaling platform.
Nguyen NT, Now H, Kim WJ, Kim N, Yoo JY
Scientific reports 2016 Mar 21;6:23377
Scientific reports 2016 Mar 21;6:23377
The presence of disulfide bonds reveals an evolutionarily conserved mechanism involved in mitochondrial protein translocase assembly.
Wrobel L, Sokol AM, Chojnacka M, Chacinska A
Scientific reports 2016 Jun 6;6:27484
Scientific reports 2016 Jun 6;6:27484
p38 MAP kinase-dependent phosphorylation of the Gp78 E3 ubiquitin ligase controls ER-mitochondria association and mitochondria motility.
Li L, Gao G, Shankar J, Joshi B, Foster LJ, Nabi IR
Molecular biology of the cell 2015 Nov 1;26(21):3828-40
Molecular biology of the cell 2015 Nov 1;26(21):3828-40
Disrupted-in-schizophrenia-1 (DISC1) Regulates Endoplasmic Reticulum Calcium Dynamics.
Park SJ, Jeong J, Park YU, Park KS, Lee H, Lee N, Kim SM, Kuroda K, Nguyen MD, Kaibuchi K, Park SK
Scientific reports 2015 Mar 3;5:8694
Scientific reports 2015 Mar 3;5:8694
The mitochondrial citrate transporter, CIC, is essential for mitochondrial homeostasis.
Catalina-Rodriguez O, Kolukula VK, Tomita Y, Preet A, Palmieri F, Wellstein A, Byers S, Giaccia AJ, Glasgow E, Albanese C, Avantaggiati ML
Oncotarget 2012 Oct;3(10):1220-35
Oncotarget 2012 Oct;3(10):1220-35
Mitofilin regulates cytochrome c release during apoptosis by controlling mitochondrial cristae remodeling.
Yang RF, Zhao GW, Liang ST, Zhang Y, Sun LH, Chen HZ, Liu DP
Biochemical and biophysical research communications 2012 Nov 9;428(1):93-8
Biochemical and biophysical research communications 2012 Nov 9;428(1):93-8
Molecular characterization of mitofilin (HMP), a mitochondria-associated protein with predicted coiled coil and intermembrane space targeting domains.
Odgren PR, Toukatly G, Bangs PL, Gilmore R, Fey EG
Journal of cell science 1996 Sep;109 ( Pt 9):2253-64
Journal of cell science 1996 Sep;109 ( Pt 9):2253-64
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: Mitofilin Antibody [NB100-1919] - Western blot of dog testis. Total protein extract 1:2000 dilution of antibody.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: Mitofilin Antibody [NB100-1919] - IHC-P analysis of Mitofilin/Mitochondrial inner membrane protein in a transverse section of normal human skeletal muscle using Mitofilin antibody at 1:200 dilution. The myocytes showed an expected and very specific granular staining in the cytoplasm. [10X Magnification]
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: Mitofilin Antibody [NB100-1919] - IHC-P detection of Mitofilin/Mitochondrial inner membrane protein in a section of normal human skin using Mitofilin antibody at 1:200 dilution. Specific cytoplasmic positivity of Mitofilin was observed in the keratinocytes as well as other cells of the epidermal layer except for basal cells and dermal connective tissue. [10X Magnification]
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: Mitofilin Antibody [NB100-1919] - IHC-P detection of Mitofilin/Mitochondrial inner membrane protein in a section of normal human skin using Mitofilin antibody at 1:200 dilution. The representative image shows a specific and expected granular staining of Mitofilin in the keratinocytes as well as the other cells of epidermal layer with no staining in basal cells. [60X Magnification]
