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Western blotAntibody data
- Antibody Data
- Antigen structure
- References [21]
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- Product number
- 66797-1-Ig - Provider product page
- Provider
- Proteintech Group
- Product name
- SOCS3 antibody
- Antibody type
- Monoclonal
- Description
- SOCS3 antibody (Cat. #66797-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human, mouse and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 1G2B12
- Vial size
- 20ul, 150ul
Submitted references Bioinspired cardiac-targeted metal-organic framework nanozyme for modulating inflammatory responses in heart failure with preserved ejection fraction.
Regulatory T cells attenuate astrogliosis via IL-10/STAT3/PKC/vimentin signaling and promote neurological recovery after spinal cord injury.
Quercetin pretreated umbilical cord mesenchymal stem cells alleviate inflammatory bowel disease via IL-10 /Janus kinase 2/STAT3 signaling.
TLR-4Ab and IFNγAb with exogenous IL-10 treated LPS induced mice shown differential inflammatory response upon RANKL-M-CSF stimulation in resident bone marrow cells.
Dual neutralization of TGF-β and IL-21 regulates Th17/Treg balance by suppressing inflammatory signalling in the splenic lymphocytes of Staphylococcus aureus infection-induced septic arthritic mice.
TLR4/TNFR1 blockade suppresses STAT1/STAT3 expression and increases SOCS3 expression in modulation of LPS-induced macrophage responses.
Verapamil and tangeretin enhances the M1 macrophages to M2 type in lipopolysaccharide-treated mice and inhibits the P-glycoprotein expression by downregulating STAT1/STAT3 and upregulating SOCS3.
IL-17A produced by POMC neurons regulates diet-induced obesity.
Endogenous blocking of TLR2 along with TNF-α and IL-1β ameliorates the severity of the S. aureus arthritis via modulating STAT3/SOCS3 expressions in tissue resident macrophages.
PTK6 inhibits autophagy to promote uveal melanoma tumorigenesis by binding to SOCS3 and regulating mTOR phosphorylation.
Simiao San alleviates hyperuricemia and kidney inflammation by inhibiting NLRP3 inflammasome and JAK2/STAT3 signaling in hyperuricemia mice.
Apigenin Ameliorates Hyperuricemia and Renal Injury through Regulation of Uric Acid Metabolism and JAK2/STAT3 Signaling Pathway.
Epac activation ameliorates tubulointerstitial inflammation in diabetic nephropathy.
Single Treatment of Vitamin D3 Ameliorates LPS-Induced Acute Lung Injury through Changing Lung Rodentibacter abundance.
Investigation of the mechanism of Isobavachalcone in treating rheumatoid arthritis through a combination strategy of network pharmacology and experimental verification.
Autophagy Drives Galectin-1 Secretion From Tumor-Associated Macrophages Facilitating Hepatocellular Carcinoma Progression.
STAT3 and IL-6 Contribute to Corticosteroid Resistance in an OVA and Ozone-induced Asthma Model with Neutrophil Infiltration.
Identification of the Prognostic Value Among Suppressor Of Cytokine Signaling Family Members in Kidney Renal Clear Cell Carcinoma.
Alterations in Leptin Signaling in Amyotrophic Lateral Sclerosis (ALS).
Leptin Modulates the Response of Brown Adipose Tissue to Negative Energy Balance: Implication of the GH/IGF-I Axis.
Phosphorylated nuclear factor erythroid 2-related factor 2 promotes the secretion of C-C motif chemokine ligand 2 and the recruitment of M2 macrophages.
Gui Y, Fan X, Xiao K, Xing J, Niu Z, Wang Y, Yuan W, Shen J, Shi Y, Cheng X, Han Y, Li Z, Tang H
Frontiers in bioengineering and biotechnology 2026;14:1744643
Frontiers in bioengineering and biotechnology 2026;14:1744643
Regulatory T cells attenuate astrogliosis via IL-10/STAT3/PKC/vimentin signaling and promote neurological recovery after spinal cord injury.
Li Y, Xie Y, Liu R, Huang H, Wang Z, Liu X, Yu Z, Wang M, Wang W, Luo X
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2026 Jan;23(1):e00827
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2026 Jan;23(1):e00827
Quercetin pretreated umbilical cord mesenchymal stem cells alleviate inflammatory bowel disease via IL-10 /Janus kinase 2/STAT3 signaling.
Shi MY, Liu L, Yang FY
World journal of stem cells 2025 Sep 26;17(9):105896
World journal of stem cells 2025 Sep 26;17(9):105896
TLR-4Ab and IFNγAb with exogenous IL-10 treated LPS induced mice shown differential inflammatory response upon RANKL-M-CSF stimulation in resident bone marrow cells.
Mukherjee G, Samanta S, Bishayi B
Microbial pathogenesis 2025 May;202:107416
Microbial pathogenesis 2025 May;202:107416
Dual neutralization of TGF-β and IL-21 regulates Th17/Treg balance by suppressing inflammatory signalling in the splenic lymphocytes of Staphylococcus aureus infection-induced septic arthritic mice.
Pramanik R, Chattopadhyay S, Bishayi B
Immunologic research 2025 Jan 20;73(1):38
Immunologic research 2025 Jan 20;73(1):38
TLR4/TNFR1 blockade suppresses STAT1/STAT3 expression and increases SOCS3 expression in modulation of LPS-induced macrophage responses.
Sawoo R, Bishayi B
Immunobiology 2024 Sep;229(5):152840
Immunobiology 2024 Sep;229(5):152840
Verapamil and tangeretin enhances the M1 macrophages to M2 type in lipopolysaccharide-treated mice and inhibits the P-glycoprotein expression by downregulating STAT1/STAT3 and upregulating SOCS3.
Kundu A, Ghosh P, Bishayi B
International immunopharmacology 2024 May 30;133:112153
International immunopharmacology 2024 May 30;133:112153
IL-17A produced by POMC neurons regulates diet-induced obesity.
Gallo R, Teijeiro A, Angulo-Aguado M, Djouder N
iScience 2024 Jul 19;27(7):110259
iScience 2024 Jul 19;27(7):110259
Endogenous blocking of TLR2 along with TNF-α and IL-1β ameliorates the severity of the S. aureus arthritis via modulating STAT3/SOCS3 expressions in tissue resident macrophages.
Ghosh R, Bishayi B
Microbial pathogenesis 2024 Feb;187:106518
Microbial pathogenesis 2024 Feb;187:106518
PTK6 inhibits autophagy to promote uveal melanoma tumorigenesis by binding to SOCS3 and regulating mTOR phosphorylation.
Liu B, Yao X, Zhang C, Liu Y, Wei L, Huang Q, Wang M, Zhang Y, Hu D, Wu W
Cell death & disease 2023 Jan 23;14(1):55
Cell death & disease 2023 Jan 23;14(1):55
Simiao San alleviates hyperuricemia and kidney inflammation by inhibiting NLRP3 inflammasome and JAK2/STAT3 signaling in hyperuricemia mice.
Zhang Y, Wang S, Dai X, Liu T, Liu Y, Shi H, Yin J, Xu T, Zhang Y, Zhao D, Sukhorukov V, Orekhov AN, Gao S, Wang L, Zhang D
Journal of ethnopharmacology 2023 Aug 10;312:116530
Journal of ethnopharmacology 2023 Aug 10;312:116530
Apigenin Ameliorates Hyperuricemia and Renal Injury through Regulation of Uric Acid Metabolism and JAK2/STAT3 Signaling Pathway.
Liu T, Gao H, Zhang Y, Wang S, Lu M, Dai X, Liu Y, Shi H, Xu T, Yin J, Gao S, Wang L, Zhang D
Pharmaceuticals (Basel, Switzerland) 2022 Nov 21;15(11)
Pharmaceuticals (Basel, Switzerland) 2022 Nov 21;15(11)
Epac activation ameliorates tubulointerstitial inflammation in diabetic nephropathy.
Yang WX, Liu Y, Zhang SM, Wang HF, Liu YF, Liu JL, Li XH, Zeng MR, Han YZ, Liu FY, Sun L, Xiao L
Acta pharmacologica Sinica 2022 Mar;43(3):659-671
Acta pharmacologica Sinica 2022 Mar;43(3):659-671
Single Treatment of Vitamin D3 Ameliorates LPS-Induced Acute Lung Injury through Changing Lung Rodentibacter abundance.
Jin A, Zhao Y, Yuan Y, Ma S, Chen J, Yang X, Lu S, Sun Q
Molecular nutrition & food research 2022 Feb;66(3):e2100952
Molecular nutrition & food research 2022 Feb;66(3):e2100952
Investigation of the mechanism of Isobavachalcone in treating rheumatoid arthritis through a combination strategy of network pharmacology and experimental verification.
Wang S, Du Q, Sun J, Geng S, Zhang Y
Journal of ethnopharmacology 2022 Aug 10;294:115342
Journal of ethnopharmacology 2022 Aug 10;294:115342
Autophagy Drives Galectin-1 Secretion From Tumor-Associated Macrophages Facilitating Hepatocellular Carcinoma Progression.
Davuluri GVN, Chen CC, Chiu YC, Tsai HW, Chiu HC, Chen YL, Tsai PJ, Kuo WT, Tsao N, Lin YS, Chang CP
Frontiers in cell and developmental biology 2021;9:741820
Frontiers in cell and developmental biology 2021;9:741820
STAT3 and IL-6 Contribute to Corticosteroid Resistance in an OVA and Ozone-induced Asthma Model with Neutrophil Infiltration.
Xue Y, Zhou Y, Bao W, Fu Q, Hao H, Han L, Zhang X, Tian X, Zhang M
Frontiers in molecular biosciences 2021;8:717962
Frontiers in molecular biosciences 2021;8:717962
Identification of the Prognostic Value Among Suppressor Of Cytokine Signaling Family Members in Kidney Renal Clear Cell Carcinoma.
Li C, Zhang W, Fang T, Li N, Wang Y, He L, He H
Frontiers in molecular biosciences 2021;8:585000
Frontiers in molecular biosciences 2021;8:585000
Alterations in Leptin Signaling in Amyotrophic Lateral Sclerosis (ALS).
Ferrer-Donato A, Contreras A, Frago LM, Chowen JA, Fernandez-Martos CM
International journal of molecular sciences 2021 Sep 24;22(19)
International journal of molecular sciences 2021 Sep 24;22(19)
Leptin Modulates the Response of Brown Adipose Tissue to Negative Energy Balance: Implication of the GH/IGF-I Axis.
Barrios V, Frago LM, Canelles S, Guerra-Cantera S, Arilla-Ferreiro E, Chowen JA, Argente J
International journal of molecular sciences 2021 Mar 11;22(6)
International journal of molecular sciences 2021 Mar 11;22(6)
Phosphorylated nuclear factor erythroid 2-related factor 2 promotes the secretion of C-C motif chemokine ligand 2 and the recruitment of M2 macrophages.
Huang Z, Li X, Zhou T, Jiang Y, Shi JH
Annals of translational medicine 2021 Dec;9(23):1719
Annals of translational medicine 2021 Dec;9(23):1719
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