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Western blotAntibody data
- Antibody Data
- Antigen structure
- References [5]
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- Product number
- ABIN493472 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Suppressor of Cytokine Signaling 3 (SOCS3) (AA 202-225) antibody
- Antibody type
- Polyclonal
- Antigen
- Synthetic peptide corresponding to amino acids 202-225 of the Human Repressor ofcytokine signaling 3 protein. The peptide was amidated and conjugated to a carrier proteinAA Sequence: dsy ekv tql pgp ire fld qyd apl
- Reactivity
- Human, Mouse, Rat, Simian
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 0.1 mg
- Concentration
- 0.58-0.65 mg/ml (lot. sepcific)
- Storage
- Store the antibody undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Submitted references SOCS3 as a tumor suppressor in breast cancer cells, and its regulation by PRL.
Elevated expression and genetic association links the SOCS3 gene to atopic dermatitis.
SOCS2 can enhance interleukin-2 (IL-2) and IL-3 signaling by accelerating SOCS3 degradation.
The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response.
SOCS3 negatively regulates IL-6 signaling in vivo.
Barclay JL, Anderson ST, Waters MJ, Curlewis JD
International journal of cancer. Journal international du cancer 2009 Apr 15;124(8):1756-66
International journal of cancer. Journal international du cancer 2009 Apr 15;124(8):1756-66
Elevated expression and genetic association links the SOCS3 gene to atopic dermatitis.
Ekelund E, Saaf A, Tengvall-Linder M, Melen E, Link J, Barker J, Reynolds NJ, Meggitt SJ, Kere J, Wahlgren CF, Pershagen G, Wickman M, Nordenskjold M, Kockum I, Bradley M
American journal of human genetics 2006 Jun;78(6):1060-5
American journal of human genetics 2006 Jun;78(6):1060-5
SOCS2 can enhance interleukin-2 (IL-2) and IL-3 signaling by accelerating SOCS3 degradation.
Tannahill GM, Elliott J, Barry AC, Hibbert L, Cacalano NA, Johnston JA
Molecular and cellular biology 2005 Oct;25(20):9115-26
Molecular and cellular biology 2005 Oct;25(20):9115-26
The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response.
Alexander WS, Hilton DJ
Annual review of immunology 2004;22:503-29
Annual review of immunology 2004;22:503-29
SOCS3 negatively regulates IL-6 signaling in vivo.
Croker BA, Krebs DL, Zhang JG, Wormald S, Willson TA, Stanley EG, Robb L, Greenhalgh CJ, Förster I, Clausen BE, Nicola NA, Metcalf D, Hilton DJ, Roberts AW, Alexander WS
Nature immunology 2003 Jun;4(6):540-5
Nature immunology 2003 Jun;4(6):540-5
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