11251-1-AP

antibody from Proteintech Group

Targeting: SUMO2 SMT3B, SMT3H2

Provider product page for 11251-1-AP

Western blot

ELISA

Immunocytochemistry

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [33]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [1]

Submit

Product number: 11251-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#11251-1-AP, RRID:AB_2198405
Product name: SUMO2/3 antibody
Antibody type: Polyclonal
Description: KD/KO validated SUMO2/3 antibody (Cat. #11251-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, WB,ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

SUMO2 protein structure - 11251-1-AP shown in red.

Submitted references SENP6 Restrains NLRP3 Inflammasome Activation via DeSUMOylation-Driven K48-Linked Ubiquitination of NLRP3 in Acute Lung Injury.

Gu A, Wang B, Zhang Y, Sun C, Wei Y, Yan J, Yang Y, Wang Y, Liu R, Zhang R, Liu J, Gu C, Wang Y
Research (Washington, D.C.) 2026;9:1069

SUMO-conjugating enzyme UBE2I inhibition alleviates asthma progression: effects on BHLHE40 and M2 macrophage polarization.

Lin H, Yu S, Li X, Yu L, Chen X, Pang Y, Lv R, Dai B, Zhou Q, Shan L
International immunopharmacology 2026 Jul 1;180:116673

EBNA1 SUMOylation by PIAS1 suppresses EBV lytic replication and enhances episome maintenance.

Sugiokto FG, Zhang K, Maharjan Y, Li R
mBio 2026 Jan 14;17(1):e0263925

SENP3/FIS1-regulated PFC neural mitochondrial fragmentation underlies the mechanism of electroacupuncture attenuating depressive behavior in CUMS mice.

Lai S, Qiu X, Lin P, Wu J, Li F, Lai N, Li X, Tu T, Zhang J, Huang Y, Zhang Z
Frontiers in psychiatry 2025;16:1645757

SUMOylation of SARS-CoV-2 spike protein is a key target for broad-spectrum antiviral therapy.

Wang X, Hu G, Shao Y, Dong Z, Liu L, Wang Y, Xie Y, Yu N, Zhu C, Wei F, Jia Y, Wang Y, Cai Q
Theranostics 2025;15(13):6369-6386

Ovarian SUMO-2/3 targets and their differential response to genotoxic stress induced by 7,12-dimethylbenz(a) anthracene exposure in lean and obese female mice†.

Rishi JK, Montes C, Walley JW, Keating AF
Biology of reproduction 2025 Oct 14;113(4):962-976

Antimony exposure induces bladder cancer metastasis via activation of the SUMOylation-dependent TGF-β/Smad2/3 axis.

Yi B, Zhao Z, Gao X, Zhao D, Liu X, Zhang W, Zhang Z, Zhang C
Environmental research 2025 Nov 15;285(Pt 4):122589

SENP5 promotes endometrial cancer cell growth by regulating β-catenin deSUMOylation to enhance GPX4-resistance to ferroptosis.

Wang Z, Zhang Y, Zhang Y, Deng Q, Xi Y, He W, Ma X
European journal of medical research 2025 May 24;30(1):411

Redox regulation of TRIM28 facilitates neuronal ferroptosis by promoting SUMOylation and inhibiting OPTN-selective autophagic degradation of ACSL4.

Liu W, Zhu Y, Ye W, Xiong J, Wang H, Gao Y, Huang S, Zhang Y, Zhou X, Zhou X, Ge X, Cai W, Zheng X
Cell death and differentiation 2025 Jun;32(6):1041-1057

YY1 enhances HIF-1α stability in tumor-associated macrophages to suppress anti-tumor immunity of prostate cancer in mice.

Li W, Chen S, Lu J, Mao W, Zheng S, Zhang M, Wu T, Chen Y, Lu K, Chu C, Shu C, Hou Y, Yang X, Shi N, Chen Z, Zhang L, Zhang L, Na R, Chen M, Ju S, Zhang D, Ma Y, Xu B
Nature communications 2025 Jul 7;16(1):6261

Promyelocytic Leukemia Protein (PML) Regulates Stem Cell Pluripotency Through Novel Sumoylation Targets.

Spanou S, Makatounakis T, Filippopoulou C, Dougalis G, Stamatakis G, Nikolaou C, Samiotaki M, Chachami G, Papamatheakis J, Kretsovali A
International journal of molecular sciences 2025 Jan 28;26(3)

Hypoxia-mediated SUMOylation of FADD exacerbates endothelial cell injury via the RIPK1-RIPK3-MLKL signaling axis.

Yang L, Wen Y, Yuan Z, Zhao D, Weng P, Li Y, Chen Q, Zhang W, Hu H, Yu C
Cell death & disease 2025 Feb 21;16(1):121

METTL10-Mediated PIAS3 Methylation Links Purine Metabolism to Gastric Cancer Progression.

Tan J, Zhou H, Ma J, Zhang C, Tan Y, Zhang B, Zhao J, Cheng A, Yang C, Xu M, Zhou S, Xiong Y, Lin Z, Pan G, Ye W, Zhong M, Yang Y, Zhuang Y, Li SW, Deng X, Hong X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(48):e07054

SUMO E3 ligase MUL1 inhibits lymph node metastasis of bladder cancer by mediating mitochondrial HSPA9 translocation.

Wu J, Huang M, Dong W, Chen Y, Zhou Q, Zhang Q, Zheng J, Liu Y, Zhang Y, Liu S, Yang C, Chen S, Huang J, Lin T, Chen X
International journal of biological sciences 2024;20(10):3986-4006

Isoginkgetin and Madrasin are poor splicing inhibitors.

Tellier M, Ansa G, Murphy S
PloS one 2024;19(10):e0310519

Crosstalk between PKA and PIAS3 regulates cardiac Kv4 channel SUMOylation.

Jansen LR, Welch MA, Plant LD, Baro DJ
Cell communication and signaling : CCS 2024 Sep 2;22(1):422

Impaired SUMOylation of FoxA1 promotes nonalcoholic fatty liver disease through down-regulation of Sirt6.

Zou D, Liao J, Xiao M, Liu L, Dai D, Xu M
Cell death & disease 2024 Sep 14;15(9):674

Transcription factor E2F4 facilitates SUMOylation to promote HCC progression through interaction with LIN9.

Ma Z, Li Q, Wang W, Deng Z
International journal of oncology 2024 Oct;65(4)

LncRNA HOTAIRM1 promotes radioresistance in nasopharyngeal carcinoma by modulating FTO acetylation-dependent alternative splicing of CD44.

Mi J, Wang Y, He S, Qin X, Li Z, Zhang T, Huang W, Wang R
Neoplasia (New York, N.Y.) 2024 Oct;56:101034

Mutation of the SUMOylation site of Aurora-B disrupts spindle formation and chromosome alignment in oocytes.

Chen SS, Li L, Yao B, Guo JL, Lu PS, Zhang HL, Zhang KH, Zou YJ, Luo NJ, Sun SC, Hu LL, Ren YP
Cell death discovery 2024 Oct 22;10(1):447

A TOPBP1 allele causing male infertility uncouples XY silencing dynamics from sex body formation.

Ascenção C, Sims JR, Dziubek A, Comstock W, Fogarty EA, Badar J, Freire R, Grimson A, Weiss RS, Cohen PE, Smolka MB
eLife 2024 Feb 23;12

Astragaloside IV combined with ligustrazine ameliorates abnormal mitochondrial dynamics via Drp1 SUMO/deSUMOylation in cerebral ischemia-reperfusion injury.

Chen X, Yang T, Zhou Y, Mei Z, Zhang W
CNS neuroscience & therapeutics 2024 Apr;30(4):e14725

EVC-EVC2 complex stability and ciliary targeting are regulated by modification with ubiquitin and SUMO.

Barbeito P, Martin-Morales R, Palencia-Campos A, Cerrolaza J, Rivas-Santos C, Gallego-Colastra L, Caparros-Martin JA, Martin-Bravo C, Martin-Hurtado A, Sánchez-Bellver L, Marfany G, Ruiz-Perez VL, Garcia-Gonzalo FR
Frontiers in cell and developmental biology 2023;11:1190258

SUMO1-regulated DBC1 promotes p53-dependent stress-induced apoptosis of lens epithelial cells.

Wang Y, Wang JM, Xiao Y, Hu XB, Zheng SY, Fu JL, Zhang L, Gan YW, Liang XM, Li DW
Aging 2023 Sep 7;15(17):8812-8832

Seizure enhances SUMOylation and zinc-finger transcriptional repression in neuronal nuclei.

Soon HR, Gaunt JR, Bansal VA, Lenherr C, Sze SK, Ch'ng TH
iScience 2023 Sep 15;26(9):107707

SENP1 Decreases RNF168 Phase Separation to Promote DNA Damage Repair and Drug Resistance in Colon Cancer.

Wei M, Huang X, Liao L, Tian Y, Zheng X
Cancer research 2023 Sep 1;83(17):2908-2923

Alternative transcribed 3' isoform of long non-coding RNA Malat1 inhibits mouse retinal oxidative stress.

Ghanam AR, Ke S, Wang S, Elgendy R, Xie C, Wang S, Zhang R, Wei M, Liu W, Cao J, Zhang Y, Zhang Z, Xue T, Zheng Y, Song X
iScience 2023 Jan 20;26(1):105740

XAF1 promotes anti-RNA virus immune responses by regulating chromatin accessibility.

Kuang M, Zhao Y, Yu H, Li S, Liu T, Chen L, Chen J, Luo Y, Guo X, Wei X, Li Y, Zhang Z, Wang D, You F
Science advances 2023 Aug 18;9(33):eadg5211

SENP3 and USP7 regulate Polycomb-rixosome interactions and silencing functions.

Zhou H, Feng W, Yu J, Shafiq TA, Paulo JA, Zhang J, Luo Z, Gygi SP, Moazed D
Cell reports 2023 Apr 25;42(4):112339

Proteomic Profiling Identifies Kaposi's Sarcoma-Associated Herpesvirus (KSHV)-Encoded LANA(SIM)-Associated Proteins in Hypoxia.

Liu X, Gan J, Du S, Zhu C, Wang Y, Jia Y, Zhang D, Qu D, Wei F, Robertson ES, Cai Q
mSystems 2021 Dec 21;6(6):e0110921

NUSAP1 potentiates chemoresistance in glioblastoma through its SAP domain to stabilize ATR.

Zhao Y, He J, Li Y, Lv S, Cui H
Signal transduction and targeted therapy 2020 Apr 22;5(1):44

Chlorogenic acid effectively treats cancers through induction of cancer cell differentiation.

Huang S, Wang LL, Xue NN, Li C, Guo HH, Ren TK, Zhan Y, Li WB, Zhang J, Chen XG, Han YX, Zhang JL, Jiang JD
Theranostics 2019;9(23):6745-6763

SUMO2 modification of Aurora B and its impact on follicular development and atresia in the mouse ovary.

Cao J, Liu XM, Huang LL, Wang L, Jiao XF, Huo LJ
International journal of molecular medicine 2018 Jun;41(6):3115-3126

No comments: Submit comment

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Apoptosised HeLa cells were subjected to SDS PAGE followed by western blot with 11251-1-AP(SUMO2/3 antibody) at dilution of 1:100
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The SUMO2/3 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human SUMO2/3. This antibody recognizes human,mouse,rat antigen. The SUMO2/3 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 11251-1-AP.pdf

: Show more