22399-1-AP

antibody from Proteintech Group

Targeting: SDCBP MDA-9, SYCL

Provider product page for 22399-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [41]
Comments [0]
Validations
Western blot [1]
Immunoprecipitation [1]
Flow cytometry [1]

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Product number: 22399-1-AP - Provider product page
Provider: Proteintech Group
Product name: Syntenin-1 antibody
Antibody type: Polyclonal
Description: KD/KO validated Syntenin-1 antibody (Cat. #22399-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: FC, IF, IHC, IP, WB,ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

SDCBP protein structure - 22399-1-AP shown in red.

Submitted references Andrographolide targets syndecan4 to impair its interaction with syntenin and inhibits the biogenesis of small extracellular vesicles.

Gong Q, Zhao W, Wang T, Pan Y, Cui C, Qu Y, Zhou X
The Journal of biological chemistry 2026 Mar;302(3):111182

From stem cells to nanomedicine: A multimodal approach targeting pancreatic fibrosis via MFGE8-dependent ANXA1-SMAD2/3 axis.

Xie W, Luo T, Tang G, Ma Z, Gong J, Yang T, Zhou J, Song Z
International journal of biological macromolecules 2026 Jan;338(Pt 1):149698

Autophagy and exosomes play different roles in the disposal of unwanted cellular materials.

Mao K, Wei L, Huo F, Xiong S, Fu Y
The FEBS journal 2026 Jan;293(1):239-256

Proteomics analysis of serum extracellular vesicle identifies UCHL1 as a potential therapeutic target for high grade serous ovarian cancer.

Lokman NA, Macpherson AM, Thompson AR, Price ZK, Goonetilleke L, Condina MR, Young C, Hoffmann P, Oehler MK, Ricciardelli C
British journal of cancer 2026 Jan;134(2):195-207

Neuroprotective Effects of Desert Milk Exosomes in LPS-Induced Cognitive Decline: Role of Microglial M2 Polarization and AMPK Signaling.

Li Y, Lu W, Qian W, Liao X, Wang P, Wang Y, Jiao W, Wang M, Zhao J, Yang J, Gao H, Li H
Nutrients 2026 Jan 19;18(2)

Glioma Cell-Derived Apoptotic Extracellular Vesicles Promote Tumorigenesis and Temozolomide Resistance by Delivering LncRNA-XIST.

Du P, Guan Y
Journal of biochemical and molecular toxicology 2026 Feb;40(2):e70735

WISP3 upregulates SDCBP expression to promote the progression of non-small cell lung cancer via the TGF-β signaling pathway.

Zhang X, Jiang T, Ye L, Sun J, Wang L, Li J, Wu F, Ren S, Gao G
Biochemical pharmacology 2025 Oct;240:117082

Succinic Acid-Induced Macrophage Endocytosis Promotes Extracellular Vesicle-Based Integrin Beta1 Transfer Accelerating Fibroblast Activation and Sepsis-Associated Pulmonary Fibrosis.

Yang W, Tang R, Zhou Y, Zhang J, Mei S, Peng Y, Huang X, Xing S, Gao Y, Xu Q, He Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(43):e07411

Identification of a Biomarker Panel in Extracellular Vesicles Derived From Non-Small Cell Lung Cancer (NSCLC) Through Proteomic Analysis and Machine Learning.

Yuan Y, Jiang H, Xue R, Feng XJ, Liu BF, Li L, Peng B, Ren CS, Li SM, Li N, Li M, Wang DB, Zhang XE
Journal of extracellular vesicles 2025 May;14(5):e70078

DDX5 super-enhancer promotes vasculogenic mimicry formation and metastasis in nasopharyngeal carcinoma by enhancing ADAM10 transcription.

Xia T, Yin H, Zhu Q, Zhang K, Xie H, Shan Y, Zhang S, Zhu R, Li K, Miao M, Lu Y, Wang Z, Zhao J, You Y, You B
Cell reports. Medicine 2025 Jun 17;6(6):102146

Phosphorylation of syntenin-1 by TBK1 promotes proliferation and migration of non-small cell lung cancer cells.

Gao L, Zou H, Xie G, Li X, Chen Z
The Journal of biological chemistry 2025 Jul;301(7):110278

Yang LJ, Song NN, Deng NS, Zhu MJ, Li QQ, Huang SS, Shi X, Hu ZH, Nie HX
Scientific reports 2025 Jul 9;15(1):24779

Adipose tissue macrophages-derived exosomal MiR-500a-5p under high glucose promotes adipocytes inflammation by suppressing Nrf2 expression.

Li YZ, Tian Y, Yang C, Liu YF, Qu SL, Huang L, Zhang C
The international journal of biochemistry & cell biology 2025 Jan;178:106713

Transplantation of gasdermin pores by extracellular vesicles propagates pyroptosis to bystander cells.

Wright SS, Kumari P, Fraile-Ágreda V, Wang C, Shivcharan S, Kappelhoff S, Margheritis EG, Matz A, Vasudevan SO, Rubio I, Bauer M, Zhou B, Vanaja SK, Cosentino K, Ruan J, Rathinam VA
Cell 2025 Jan 23;188(2):280-291.e17

MFGE8 induces anti-PD-1 therapy resistance by promoting extracellular vesicle sorting of PD-L1.

Wang W, Chen J, Wang S, Sun X, Yang J, Yu P, Hu G, Wang J, Zhang J, Qiao S, Wang J, Zhang G, He Y, Feng H, Cai Z
Cell reports. Medicine 2025 Feb 18;6(2):101922

Decoding SDCBP's role in tumor progression and immune cells infiltration: from databases to macrophage validation.

Zhao C, Zhang C, Zhang X, Du C, Liu W, Zhou Q, Dong J, Yang F, Dang Y, Yang A, Wang M, Wang C, Li M
Discover oncology 2025 Dec 21;17(1):146

Autophagic extracellular vesicles (AEVs) are distinct from exosomes and play crucial roles in viral infections.

Mao K, Huo F, Wei H, Wang F, Xiong S, Fu Y
Nature communications 2025 Dec 21;17(1):1095

Arachidonic acid triggers spermidine synthase secretion from primary tumor to induce skeletal muscle weakness upon irradiation.

Zhang X, Nie Z, Wang S, Ma Y, Han D, Hu T, Liu L, Men L, Zhang T, Wu X, Li X, Hu S, Yuan M, Liu L, Wang C, Xu P, Xiang L, Liu J, Zhang Y, Zhu D, Lei H, Zhang L, Li X, Zhao Y, Yan W
Cell metabolism 2025 Aug 5;37(8):1766-1782.e12

Complement Receptor 3 Regulates Microglial Exosome Release and Related Neurotoxicity via NADPH Oxidase in Neuroinflammation Associated with Parkinson's Disease.

Ma Y, Zhang X, Xu J, Luo R, Li S, Su H, Wang Q, Hou L
Antioxidants (Basel, Switzerland) 2025 Aug 5;14(8)

Human trabecular meshwork stem cell-derived small extracellular vesicles enhance trabecular meshwork cell survival and proliferation.

Iswarya R, Krishnadas S, Dharmalingam K, Gowri Priya C
Experimental eye research 2025 Apr;253:110281

The assembly of RAB22A/TMEM33/RTN4 initiates a secretory ER-phagy pathway.

Zheng X, Fang D, Shan H, Xiao B, Wei D, Ouyang Y, Huo L, Zhang Z, Wu Y, Zhang R, Kang T, Gao Y
Cell discovery 2025 Apr 29;11(1):41

Isolation and characterization of small extracellular vesicles from murine primary mammary tumor.

Hu S, Zhang X, Yan W
STAR protocols 2024 Mar 15;5(1):102783

SEVtras delineates small extracellular vesicles at droplet resolution from single-cell transcriptomes.

He R, Zhu J, Ji P, Zhao F
Nature methods 2024 Feb;21(2):259-266

Exosome-Mediated Paracrine Signaling Unveils miR-1246 as a Driver of Aggressiveness in Fusion-Negative Rhabdomyosarcoma.

Ramadan F, Saab R, Ghamloush F, Khoueiry R, Herceg Z, Gomez L, Badran B, Clezardin P, Hussein N, Cohen PA, Ghayad SE
Cancers 2024 Apr 25;16(9)

Presence of Intact Hepatitis B Virions in Exosomes.

Wu Q, Glitscher M, Tonnemacher S, Schollmeier A, Raupach J, Zahn T, Eberle R, Krijnse-Locker J, Basic M, Hildt E
Cellular and molecular gastroenterology and hepatology 2023;15(1):237-259

Comparison of proteomic landscape of extracellular vesicles in pleural effusions isolated by three strategies.

Yao X, Liao B, Chen F, Liu L, Wu K, Hao Y, Li Y, Wang Y, Fan R, Yin J, Liu L, Guo Y
Frontiers in bioengineering and biotechnology 2023;11:1108952

Extracellular vesicles from Zika virus-infected cells display viral E protein that binds ZIKV-neutralizing antibodies to prevent infection enhancement.

Zhao F, Xu Y, Liu N, Lv D, Chen Y, Liu Z, Jin X, Xiao M, Lavillette D, Zhong J, Bartenschlager R, Long G
The EMBO journal 2023 Mar 15;42(6):e112096

Lysine butyrylation of HSP90 regulated by KAT8 and HDAC11 confers chemoresistance.

He Y, Zheng CC, Yang J, Li SJ, Xu TY, Wei X, Chen WY, Jiang ZL, Xu JJ, Zhang GG, Cheng C, Chen KS, Shi XY, Qin DJ, Liu JB, Li B
Cell discovery 2023 Jul 18;9(1):74

Tumor Necrosis Factor Alpha Preconditioned Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles Enhance the Inhibition of Necroptosis of Acinar cells in Severe Acute Pancreatitis.

Xie W, Luo T, Ma Z, Xue S, Jia X, Yang T, Song Z
Tissue engineering. Part A 2023 Dec;29(23-24):607-619

Exosomes from TNF-α preconditioned human umbilical cord mesenchymal stromal cells inhibit the autophagy of acinar cells of severe acute pancreatitis via shuttling bioactive metabolites.

Ma Z, Xie W, Luo T, Hu Z, Hua J, Zhou J, Yang T, Wang W, Song Z, Yu X, Xu J, Shi S
Cellular and molecular life sciences : CMLS 2023 Aug 18;80(9):257

Syntenin Regulated by miR-216b Promotes Cancer Progression in Pancreatic Cancer.

Zu F, Chen H, Liu Q, Zang H, Li Z, Tan X
Frontiers in oncology 2022;12:790788

Intercellular transfer of activated STING triggered by RAB22A-mediated non-canonical autophagy promotes antitumor immunity.

Gao Y, Zheng X, Chang B, Lin Y, Huang X, Wang W, Ding S, Zhan W, Wang S, Xiao B, Huo L, Yu Y, Chen Y, Gong R, Wu Y, Zhang R, Zhong L, Wang X, Chen Q, Gao S, Jiang Z, Wei D, Kang T
Cell research 2022 Dec;32(12):1086-1104

Enterovirus 71-induced autophagosome fusion with multivesicular bodies facilitates viral RNA packaging into exosomes.

Zhang R, Chen J, Zi R, Ji L, Hu J, Wu Z, Fu Y
Microbial pathogenesis 2022 Dec;173(Pt A):105875

EV-miRome-wide profiling uncovers miR-320c for detecting metastatic colorectal cancer and monitoring the therapeutic response.

Yang CK, Hsu HC, Liu YH, Tsai WS, Ma CP, Chen YT, Tan BC, Lai YY, Chang IY, Yang C, Yang CY, Yu JS, Liu H
Cellular oncology (Dordrecht, Netherlands) 2022 Aug;45(4):621-638

Circular RNA circNFATC3 acts as a miR-9-5p sponge to promote cervical cancer development by upregulating SDC2.

Ma N, Li X, Wei H, Zhang H, Zhang S
Cellular oncology (Dordrecht, Netherlands) 2021 Feb;44(1):93-107

RAB31 marks and controls an ESCRT-independent exosome pathway.

Wei D, Zhan W, Gao Y, Huang L, Gong R, Wang W, Zhang R, Wu Y, Gao S, Kang T
Cell research 2021 Feb;31(2):157-177

Downregulation of exosomal miR‑1273a increases cisplatin resistance of non‑small cell lung cancer by upregulating the expression of syndecan binding protein.

Zhao X, Li M, Dai X, Yang Y, Peng Y, Xu C, Dai N, Wang D
Oncology reports 2020 Nov;44(5):2165-2173

Inhibitory effect of taspine derivative TAD1822-7 on tumor cell growth and angiogenesis via suppression of EphrinB2 and related signaling pathways.

Liu R, Yu R, Cui Y, Fan M, Wang B, Zhang Y
Acta pharmaceutica (Zagreb, Croatia) 2019 Sep 1;69(3):423-431

Effects of Inhibiting VPS4 Support a General Role for ESCRTs in Extracellular Vesicle Biogenesis.

Jackson CE, Scruggs BS, Schaffer JE, Hanson PI
Biophysical journal 2017 Sep 19;113(6):1342-1352

Berberine inhibits the proliferation and migration of breast cancer ZR-75-30 cells by targeting Ephrin-B2.

Ma W, Zhu M, Zhang D, Yang L, Yang T, Li X, Zhang Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2017 Feb 15;25:45-51

A taspine derivative supresses Caco-2 cell growth by competitively targeting EphrinB2 and regulating its pathway.

Dai B, Wang W, Ma Y, Liu R, Zhang Y
Oncology reports 2016 Sep;36(3):1526-34

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HepG2 cells were subjected to SDS PAGE followed by western blot with 22399-1-AP(SDCBP antibody) at dilution of 1:1000
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: IP Result of anti-SDCBP (IP:22399-1-AP, 3ug; Detection:22399-1-AP 1:1000) with HeLa cells lysate 2500ug.
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The Syntenin 1 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human Syntenin 1. This antibody recognizes human antigen. The Syntenin 1 antibody has been validated for the following applications: ELISA, WB, IP, IHC, FC analysis.
Appendix: 22399-1-AP.pdf

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