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Learn25625-1-AP
antibody from Proteintech Group
Targeting: CHCHD3
FLJ20420, Mic19, MICOS19, MINOS3, PPP1R22
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [26]
- Comments [0]
- Validations
- Western blot [3]
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- Product number
- 25625-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#25625-1-AP, RRID:AB_2687533
- Product name
- CHCHD3 antibody
- Antibody type
- Polyclonal
- Description
- CHCHD3 antibody (Cat. #25625-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Loss of MTX2 causes mitochondrial dysfunction, podocyte injury, nephrotic proteinuria and glomerulopathy in mice and patients.
Stalled translation by mitochondrial stress upregulates a CNOT4-ZNF598 ribosomal quality control pathway important for tissue homeostasis.
Selective and reversible disruption of mitochondrial inner membrane protein complexes by lipophilic cations.
Inner mitochondrial membrane structure and fusion dynamics are altered in senescent human iPSC-derived and primary rat cardiomyocytes.
A CHCHD6-APP axis connects amyloid and mitochondrial pathology in Alzheimer's disease.
Mitochondrial membrane proteins and VPS35 orchestrate selective removal of mtDNA.
The mitochondrial protein Sideroflexin 3 (SFXN3) influences neurodegeneration pathways in vivo.
Mitochondrial cristae architecture protects against mtDNA release and inflammation.
The fasting-feeding metabolic transition regulates mitochondrial dynamics.
Conserved GxxxG and WN motifs of MIC13 are essential for bridging two MICOS subcomplexes.
Low abundance of Mfn2 protein correlates with reduced mitochondria-SR juxtaposition and mitochondrial cristae density in human men skeletal muscle: Examining organelle measurements from TEM images.
MIC26 and MIC27 cooperate to regulate cardiolipin levels and the landscape of OXPHOS complexes.
Cristae undergo continuous cycles of membrane remodelling in a MICOS-dependent manner.
CHCHD10-regulated OPA1-mitofilin complex mediates TDP-43-induced mitochondrial phenotypes associated with frontotemporal dementia.
β-Hydroxybutyrate Increases Exercise Capacity Associated with Changes in Mitochondrial Function in Skeletal Muscle.
Structural Basis of Mitochondrial Scaffolds by Prohibitin Complexes: Insight into a Role of the Coiled-Coil Region.
Mapping Interactome Networks of DNAJC11, a Novel Mitochondrial Protein Causing Neuromuscular Pathology in Mice.
ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation and bioenergetics defects.
Alpha-synuclein suppresses mitochondrial protease ClpP to trigger mitochondrial oxidative damage and neurotoxicity.
Mitochondria, ER, and nuclear membrane defects reveal early mechanisms for upper motor neuron vulnerability with respect to TDP-43 pathology.
Loss of CHCHD10-CHCHD2 complexes required for respiration underlies the pathogenicity of a CHCHD10 mutation in ALS.
Cardiolipin synthesizing enzymes form a complex that interacts with cardiolipin-dependent membrane organizing proteins.
Acylglycerol Kinase Mutated in Sengers Syndrome Is a Subunit of the TIM22 Protein Translocase in Mitochondria.
Hypoxic HepG2 cell adaptation decreases ATP synthase dimers and ATP production in inflated cristae by mitofilin down-regulation concomitant to MICOS clustering.
Optic Atrophy 1 Is Epistatic to the Core MICOS Component MIC60 in Mitochondrial Cristae Shape Control.
Mitofilin and CHCHD6 physically interact with Sam50 to sustain cristae structure.
Li T, Bao Y, Xia Y, Meng H, Zhou C, Huang L, Wang X, Lai EY, Jiang P, Mao J
International journal of biological sciences 2024;20(3):937-952
International journal of biological sciences 2024;20(3):937-952
Stalled translation by mitochondrial stress upregulates a CNOT4-ZNF598 ribosomal quality control pathway important for tissue homeostasis.
Geng J, Li S, Li Y, Wu Z, Bhurtel S, Rimal S, Khan D, Ohja R, Brandman O, Lu B
Nature communications 2024 Feb 22;15(1):1637
Nature communications 2024 Feb 22;15(1):1637
Selective and reversible disruption of mitochondrial inner membrane protein complexes by lipophilic cations.
Kafkova A, Tilokani L, Trčka F, Šrámková V, Vancová M, Bílý T, Nebesářová J, Prudent J, Trnka J
Mitochondrion 2023 Jan;68:60-71
Mitochondrion 2023 Jan;68:60-71
Inner mitochondrial membrane structure and fusion dynamics are altered in senescent human iPSC-derived and primary rat cardiomyocytes.
Morris S, Molina-Riquelme I, Barrientos G, Bravo F, Aedo G, Gómez W, Lagos D, Verdejo H, Peischard S, Seebohm G, Psathaki OE, Eisner V, Busch KB
Biochimica et biophysica acta. Bioenergetics 2023 Apr 1;1864(2):148949
Biochimica et biophysica acta. Bioenergetics 2023 Apr 1;1864(2):148949
A CHCHD6-APP axis connects amyloid and mitochondrial pathology in Alzheimer's disease.
Shang Y, Sun X, Chen X, Wang Q, Wang EJ, Miller E, Xu R, Pieper AA, Qi X
Acta neuropathologica 2022 Nov;144(5):911-938
Acta neuropathologica 2022 Nov;144(5):911-938
Mitochondrial membrane proteins and VPS35 orchestrate selective removal of mtDNA.
Sen A, Kallabis S, Gaedke F, Jüngst C, Boix J, Nüchel J, Maliphol K, Hofmann J, Schauss AC, Krüger M, Wiesner RJ, Pla-Martín D
Nature communications 2022 Nov 7;13(1):6704
Nature communications 2022 Nov 7;13(1):6704
The mitochondrial protein Sideroflexin 3 (SFXN3) influences neurodegeneration pathways in vivo.
Ledahawsky LM, Terzenidou ME, Edwards R, Kline RA, Graham LC, Eaton SL, van der Hoorn D, Chaytow H, Huang YT, Groen EJN, Motyl AAL, Lamont DJ, Tokatlidis K, Wishart TM, Gillingwater TH
The FEBS journal 2022 Jul;289(13):3894-3914
The FEBS journal 2022 Jul;289(13):3894-3914
Mitochondrial cristae architecture protects against mtDNA release and inflammation.
He B, Yu H, Liu S, Wan H, Fu S, Liu S, Yang J, Zhang Z, Huang H, Li Q, Wang F, Jiang Z, Liu Q, Jiang H
Cell reports 2022 Dec 6;41(10):111774
Cell reports 2022 Dec 6;41(10):111774
The fasting-feeding metabolic transition regulates mitochondrial dynamics.
Castro-Sepúlveda M, Morio B, Tuñón-Suárez M, Jannas-Vela S, Díaz-Castro F, Rieusset J, Zbinden-Foncea H
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Oct;35(10):e21891
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Oct;35(10):e21891
Conserved GxxxG and WN motifs of MIC13 are essential for bridging two MICOS subcomplexes.
Urbach J, Kondadi AK, David C, Naha R, Deinert K, Reichert AS, Anand R
Biochimica et biophysica acta. Biomembranes 2021 Dec 1;1863(12):183683
Biochimica et biophysica acta. Biomembranes 2021 Dec 1;1863(12):183683
Low abundance of Mfn2 protein correlates with reduced mitochondria-SR juxtaposition and mitochondrial cristae density in human men skeletal muscle: Examining organelle measurements from TEM images.
Castro-Sepulveda M, Fernández-Verdejo R, Tuñón-Suárez M, Morales-Zúñiga J, Troncoso M, Jannas-Vela S, Zbinden-Foncea H
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Apr;35(4):e21553
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Apr;35(4):e21553
MIC26 and MIC27 cooperate to regulate cardiolipin levels and the landscape of OXPHOS complexes.
Anand R, Kondadi AK, Meisterknecht J, Golombek M, Nortmann O, Riedel J, Peifer-Weiß L, Brocke-Ahmadinejad N, Schlütermann D, Stork B, Eichmann TO, Wittig I, Reichert AS
Life science alliance 2020 Oct;3(10)
Life science alliance 2020 Oct;3(10)
Cristae undergo continuous cycles of membrane remodelling in a MICOS-dependent manner.
Kondadi AK, Anand R, Hänsch S, Urbach J, Zobel T, Wolf DM, Segawa M, Liesa M, Shirihai OS, Weidtkamp-Peters S, Reichert AS
EMBO reports 2020 Mar 4;21(3):e49776
EMBO reports 2020 Mar 4;21(3):e49776
CHCHD10-regulated OPA1-mitofilin complex mediates TDP-43-induced mitochondrial phenotypes associated with frontotemporal dementia.
Liu T, Woo JA, Bukhari MZ, LePochat P, Chacko A, Selenica MB, Yan Y, Kotsiviras P, Buosi SC, Zhao X, Kang DE
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Jun;34(6):8493-8509
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Jun;34(6):8493-8509
β-Hydroxybutyrate Increases Exercise Capacity Associated with Changes in Mitochondrial Function in Skeletal Muscle.
Monsalves-Alvarez M, Morales PE, Castro-Sepulveda M, Sepulveda C, Rodriguez JM, Chiong M, Eisner V, Lavandero S, Troncoso R
Nutrients 2020 Jun 29;12(7)
Nutrients 2020 Jun 29;12(7)
Structural Basis of Mitochondrial Scaffolds by Prohibitin Complexes: Insight into a Role of the Coiled-Coil Region.
Yoshinaka T, Kosako H, Yoshizumi T, Furukawa R, Hirano Y, Kuge O, Tamada T, Koshiba T
iScience 2019 Sep 27;19:1065-1078
iScience 2019 Sep 27;19:1065-1078
Mapping Interactome Networks of DNAJC11, a Novel Mitochondrial Protein Causing Neuromuscular Pathology in Mice.
Violitzi F, Perivolidi VI, Thireou T, Grivas I, Haralambous S, Samiotaki M, Panayotou G, Douni E
Journal of proteome research 2019 Nov 1;18(11):3896-3912
Journal of proteome research 2019 Nov 1;18(11):3896-3912
ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation and bioenergetics defects.
Zhao Y, Sun X, Hu D, Prosdocimo DA, Hoppel C, Jain MK, Ramachandran R, Qi X
Nature communications 2019 Mar 26;10(1):1371
Nature communications 2019 Mar 26;10(1):1371
Alpha-synuclein suppresses mitochondrial protease ClpP to trigger mitochondrial oxidative damage and neurotoxicity.
Hu D, Sun X, Liao X, Zhang X, Zarabi S, Schimmer A, Hong Y, Ford C, Luo Y, Qi X
Acta neuropathologica 2019 Jun;137(6):939-960
Acta neuropathologica 2019 Jun;137(6):939-960
Mitochondria, ER, and nuclear membrane defects reveal early mechanisms for upper motor neuron vulnerability with respect to TDP-43 pathology.
Gautam M, Jara JH, Kocak N, Rylaarsdam LE, Kim KD, Bigio EH, Hande Özdinler P
Acta neuropathologica 2019 Jan;137(1):47-69
Acta neuropathologica 2019 Jan;137(1):47-69
Loss of CHCHD10-CHCHD2 complexes required for respiration underlies the pathogenicity of a CHCHD10 mutation in ALS.
Straub IR, Janer A, Weraarpachai W, Zinman L, Robertson J, Rogaeva E, Shoubridge EA
Human molecular genetics 2018 Jan 1;27(1):178-189
Human molecular genetics 2018 Jan 1;27(1):178-189
Cardiolipin synthesizing enzymes form a complex that interacts with cardiolipin-dependent membrane organizing proteins.
Serricchio M, Vissa A, Kim PK, Yip CM, McQuibban GA
Biochimica et biophysica acta. Molecular and cell biology of lipids 2018 Apr;1863(4):447-457
Biochimica et biophysica acta. Molecular and cell biology of lipids 2018 Apr;1863(4):447-457
Acylglycerol Kinase Mutated in Sengers Syndrome Is a Subunit of the TIM22 Protein Translocase in Mitochondria.
Vukotic M, Nolte H, König T, Saita S, Ananjew M, Krüger M, Tatsuta T, Langer T
Molecular cell 2017 Aug 3;67(3):471-483.e7
Molecular cell 2017 Aug 3;67(3):471-483.e7
Hypoxic HepG2 cell adaptation decreases ATP synthase dimers and ATP production in inflated cristae by mitofilin down-regulation concomitant to MICOS clustering.
Plecitá-Hlavatá L, Engstová H, Alán L, Špaček T, Dlasková A, Smolková K, Špačková J, Tauber J, Strádalová V, Malínský J, Lessard M, Bewersdorf J, Ježek P
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2016 May;30(5):1941-57
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2016 May;30(5):1941-57
Optic Atrophy 1 Is Epistatic to the Core MICOS Component MIC60 in Mitochondrial Cristae Shape Control.
Glytsou C, Calvo E, Cogliati S, Mehrotra A, Anastasia I, Rigoni G, Raimondi A, Shintani N, Loureiro M, Vazquez J, Pellegrini L, Enriquez JA, Scorrano L, Soriano ME
Cell reports 2016 Dec 13;17(11):3024-3034
Cell reports 2016 Dec 13;17(11):3024-3034
Mitofilin and CHCHD6 physically interact with Sam50 to sustain cristae structure.
Ding C, Wu Z, Huang L, Wang Y, Xue J, Chen S, Deng Z, Wang L, Song Z, Chen S
Scientific reports 2015 Nov 4;5:16064
Scientific reports 2015 Nov 4;5:16064
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Supportive validation
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- A431 cells were subjected to SDS PAGE followed by western blot with 25625-1-AP( CHCHD3 Antibody) at dilution of 1:1000
- Sample type
- cell line
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The CHCHD3 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human CHCHD3. This antibody recognizes human, mouse antigen. The CHCHD3 antibody has been validated for the following applications: ELISA, WB analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse liver tissue were subjected to SDS PAGE followed by western blot with 25625-1-AP( CHCHD3 Antibody) at dilution of 1:1000
- Sample type
- tissue
