10856-1-AP

antibody from Proteintech Group

Targeting: H2AX H2AFX

Provider product page for 10856-1-AP

Western blot

ELISA

Immunocytochemistry

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [114]
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Validations
Western blot [1]
Immunocytochemistry [1]
Immunohistochemistry [1]

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Product number: 10856-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#10856-1-AP, RRID:AB_2114985
Product name: Histone H2A.X antibody
Antibody type: Polyclonal
Description: Histone H2A.X antibody (Cat. #10856-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

H2AX protein structure - 10856-1-AP shown in red.

Submitted references SiRNF8 Delivered by DNA Framework Nucleic Acid Effectively Sensitizes Chemotherapy in Colon Cancer.

Guo Z, Song H, Tian Y, Xu J, Zhang G, Guo Y, Shen R, Wang D
International journal of nanomedicine 2024;19:171-188

An interpretable artificial intelligence framework for designing synthetic lethality-based anti-cancer combination therapies.

Wang J, Wen Y, Zhang Y, Wang Z, Jiang Y, Dai C, Wu L, Leng D, He S, Bo X
Journal of advanced research 2024 Nov;65:329-343

Disrupting glycolysis and DNA repair in anaplastic thyroid cancer with nucleus-targeting platinum nanoclusters.

Pan Z, Lu X, Hu X, Yu R, Che Y, Wang J, Xiao L, Chen J, Yi X, Tan Z, Li F, Ling D, Huang P, Ge M
Journal of controlled release : official journal of the Controlled Release Society 2024 May;369:517-530

Selective Organ-Targeting Hafnium Oxide Nanoparticles with Multienzyme-Mimetic Activities Attenuate Radiation-Induced Tissue Damage.

Liu D, Cao F, Xu Z, Zhao C, Liu Z, Pang J, Liu ZX, Moghiseh M, Butler A, Liang S, Fan W, Yang J
Advanced materials (Deerfield Beach, Fla.) 2024 May;36(19):e2308098

Neuronal activity rapidly reprograms dendritic translation via eIF4G2:uORF binding.

Hacisuleyman E, Hale CR, Noble N, Luo JD, Fak JJ, Saito M, Chen J, Weissman JS, Darnell RB
Nature neuroscience 2024 May;27(5):822-835

WSB1/2 target chromatin-bound lysine-methylated RelA for proteasomal degradation and NF-κB termination.

Zhang J, Yu Y, Zou X, Du Y, Liang Q, Gong M, He Y, Luo J, Wu D, Jiang X, Sinclair M, Tajkhorshid E, Chen HZ, Hou Z, Zheng Y, Chen LF, Yang XD
Nucleic acids research 2024 May 22;52(9):4969-4984

Selenium reduces acrylamide-induced testicular toxicity in rats by regulating HSD17B1, StAR, and CYP17A1 expression, oxidative stress, inflammation, apoptosis, autophagy, and DNA damage.

Yildirim S, Sengul E, Aksu EH, Cinar İ, Gelen V, Tekin S, Dag Y
Environmental toxicology 2024 Mar;39(3):1402-1414

GSTM3 enhances radiosensitivity of nasopharyngeal carcinoma by promoting radiation-induced ferroptosis through USP14/FASN axis and GPX4.

Chen Y, Feng Y, Lin Y, Zhou X, Wang L, Zhou Y, Lin K, Cai L
British journal of cancer 2024 Mar;130(5):755-768

TRIM28-Mediated Excessive Oxidative Stress Induces Cellular Senescence in Granulosa Cells and Contributes to Premature Ovarian Insufficiency In Vitro and In Vivo.

Zhou C, Li D, He J, Luo T, Liu Y, Xue Y, Huang J, Zheng L, Li J
Antioxidants (Basel, Switzerland) 2024 Mar 1;13(3)

Mitochondrial-Targeted Copper Delivery for Cuproptosis-Based Synergistic Cancer Therapy.

Deng J, Zhuang H, Shao S, Zeng X, Xue P, Bai T, Wang X, Shangguan S, Chen Y, Yan S, Huang W
Advanced healthcare materials 2024 Jul;13(18):e2304522

SUMOylation modification of FTO facilitates oxidative damage response of arsenic by IGF2BP3 in an m6A-dependent manner.

Zhang H, Chen Q, Han H, Guo C, Jiang X, Xia Y, Zhang Y, Zhou L, Zhang J, Tian X, Mao L, Qiu J, Zou Z, Chen C
Journal of hazardous materials 2024 Jul 5;472:134440

IGF-I protects porcine granulosa cells from hypoxia-induced apoptosis by promoting homologous recombination repair through the PI3K/AKT/E2F8/RAD51 pathway.

Liu Z, Feng C, Li C, He T, Wu G, Fu C, Li H, Shen M, Liu H
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jan;38(1):e23332

A drug cocktail of rapamycin, acarbose, and phenylbutyrate enhances resilience to features of early-stage Alzheimer's disease in aging mice.

Wezeman J, Darvas M, Postupna N, Klug J, Mangalindan RS, Keely A, Nguyen K, Johnson C, Rosenfeld M, Ladiges W
bioRxiv : the preprint server for biology 2024 Jan 30;

CHEK2 knockout is a therapeutic target for TP53-mutated hepatocellular carcinoma.

Chen Y, Zhu Z, Wu X, Li H, Guan W, Ren H
Cell death discovery 2024 Jan 19;10(1):37

Cell senescence induced by toxic interaction between α-synuclein and iron precedes nigral dopaminergic neuron loss in a mouse model of Parkinson's disease.

Shen QQ, Jv XH, Ma XZ, Li C, Liu L, Jia WT, Qu L, Chen LL, Xie JX
Acta pharmacologica Sinica 2024 Feb;45(2):268-281

Leveraging synthetic lethality to uncover potential therapeutic target in gastric cancer.

Geng H, Qian R, Zhong Y, Tang X, Zhang X, Zhang L, Yang C, Li T, Dong Z, Wang C, Zhang Z, Zhu C
Cancer gene therapy 2024 Feb;31(2):334-348

ENO2 promotes anoikis resistance in anaplastic thyroid cancer by maintaining redox homeostasis.

Zhang Y, Ji X, Wang Y
Gland surgery 2024 Feb 29;13(2):209-224

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Gao F, Liang W, Chen Q, Chen B, Liu Y, Liu Z, Xu X, Zhu R, Cheng L
Nanomaterials (Basel, Switzerland) 2024 Feb 20;14(5)

Combined Metabolic Activators with Different NAD+ Precursors Improve Metabolic Functions in the Animal Models of Neurodegenerative Diseases.

Altay O, Yang H, Yildirim S, Bayram C, Bolat I, Oner S, Tozlu OO, Arslan ME, Hacimuftuoglu A, Shoaie S, Zhang C, Borén J, Uhlén M, Turkez H, Mardinoglu A
Biomedicines 2024 Apr 22;12(4)

Downregulation of VRK1 Inhibits Progression of Lung Squamous Cell Carcinoma through DNA Damage.

Du N, Zhang B, Zhang Y
Canadian respiratory journal 2023;2023:4533504

4-vinylcyclohexene diepoxide induces apoptosis by excessive reactive oxygen species and DNA damage in human ovarian granulosa cells.

Song W, Qiu YT, Li XZ, Sun QY, Chen LN
Toxicology in vitro : an international journal published in association with BIBRA 2023 Sep;91:105613

Pan-cancer integrated bioinformatic analysis of RNA polymerase subunits reveal RNA Pol I member CD3EAP regulates cell growth by modulating autophagy.

Bhandari N, Acharya D, Chatterjee A, Mandve L, Kumar P, Pratap S, Malakar P, Shukla SK
Cell cycle (Georgetown, Tex.) 2023 Sep;22(18):1986-2002

Expression of NORAD correlates with breast cancer aggressiveness and protects breast cancer cells from chemotherapy.

Alves-Vale C, Capela AM, Tavares-Marcos C, Domingues-Silva B, Pereira B, Santos F, Gomes CP, Espadas G, Vitorino R, Sabidó E, Borralho P, Nóbrega-Pereira S, Bernardes de Jesus B
Molecular therapy. Nucleic acids 2023 Sep 12;33:910-924

Sodium tanshinone IIA sulfonate ameliorates neointima by protecting endothelial progenitor cells in diabetic mice.

Heng YY, Shang HJ, Zhang XZ, Wei W
BMC cardiovascular disorders 2023 Sep 11;23(1):446

An inducible long noncoding RNA, LncZFHX2, facilitates DNA repair to mediate osteoarthritis pathology.

Ni W, Zhang H, Mei Z, Hongyi Z, Wu Y, Xu W, Ma Y, Yang W, Liang Y, Gu T, Su Y, Fan S, Shen S, Hu Z
Redox biology 2023 Oct;66:102858

The PRX-1/TLR4 axis promotes hypoxia-induced radiotherapy resistance in non-small cell lung cancer by targeting the NF-κB/p65 pathway.

Hao J, Song Z, Su J, Li L, Zou L, Zou K
Cellular signalling 2023 Oct;110:110806

A transdermal drug delivery system based on dissolving microneedles for boron neutron capture therapy of melanoma.

Li J, Wang X, Wang Z, Zhao Y, Zhang Z, Li L, Ding D, Guo J, Zhang J, Liu H, Li Z
Biomaterials science 2023 Nov 21;11(23):7568-7578

Creatine kinase brain-type regulates BCAR1 phosphorylation to facilitate DNA damage repair.

Yang B, Zhang W, Sun L, Lu B, Yin C, Zhang Y, Jiang H
iScience 2023 May 19;26(5):106684

LMNB1 deletion in ovarian cancer inhibits the proliferation and metastasis of tumor cells through PI3K/Akt pathway.

Dong J, Ru Y, Zhai L, Gao Y, Guo X, Chen B, Lv X
Experimental cell research 2023 May 15;426(2):113573

Near-Infrared Phototheranostic Iron Pyrite Nanocrystals Simultaneously Induce Dual Cell Death Pathways via Enhanced Fenton Reactions in Triple-Negative Breast Cancer.

Zhao C, Liu Z, Chang CC, Chen YC, Zhang Q, Zhang XD, Andreou C, Pang J, Liu ZX, Wang DY, Kircher MF, Yang J
ACS nano 2023 Mar 14;17(5):4261-4278

Immunostimulation with chemotherapy of a ruthenium-arene complex via blockading CD47 signal in chronic myelogenous leukemia cells.

Hu G, Lv M, Guo B, Huang Y, Su Z, Qian Y, Xue X, Liu HK
Journal of inorganic biochemistry 2023 Jun;243:112195

CUL4B orchestrates mesenchymal stem cell commitment by epigenetically repressing KLF4 and C/EBPδ.

Yu R, Han H, Chu S, Ding Y, Jin S, Wang Y, Jiang W, Liu Y, Zou Y, Wang M, Liu Q, Sun G, Jiang B, Gong Y
Bone research 2023 Jun 2;11(1):29

DON entry into the nucleus induces DNA damage, apoptosis and cycle arrest in GES-1 cells.

Hou S, Cheng Y, Wang Z, Xia L, Wang J, Wang H, Sun J, Ma J, Yan Y
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jan;171:113531

STING Suppresses Mitochondrial VDAC2 to Govern RCC Growth Independent of Innate Immunity.

Zhu Z, Zhou X, Du H, Cloer EW, Zhang J, Mei L, Wang Y, Tan X, Hepperla AJ, Simon JM, Cook JG, Major MB, Dotti G, Liu P
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Jan;10(3):e2203718

Adipose-Derived Mesenchymal Stem Cells Inhibit JNK-Mediated Mitochondrial Retrograde Pathway to Alleviate Acetaminophen-Induced Liver Injury.

Cen Y, Lou G, Qi J, Li M, Zheng M, Liu Y
Antioxidants (Basel, Switzerland) 2023 Jan 9;12(1)

Nanofibrillar peptide hydrogels for self-delivery of lonidamine and synergistic photodynamic therapy.

Wu C, Jiao Q, Wang C, Zheng Y, Pan X, Zhong W, Xu K
Acta biomaterialia 2023 Jan 1;155:139-153

TRIM24 is critical for the cellular response to DNA double-strand breaks through regulating the recruitment of MRN complex.

Wang Y, Yao Y, Wei Q, Long S, Chen Y, Xie J, Tan R, Jiang W, Zhang Q, Wu D, Xiao S, Wan F, Fu K
Oncogene 2023 Feb;42(8):586-600

Cannabidiol protects the liver from α-Amanitin-induced apoptosis and oxidative stress through the regulation of Nrf2.

Wang H, Yang G, Zhang X, Zhang H, Liu Y, Wang C, Miao L, Li Y, Huang Y, Teng H, Wang S, Cheng H, Zeng X
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Dec;182:114196

Salidroside Supplementation Affects In Vitro Maturation and Preimplantation Embryonic Development by Promoting Meiotic Resumption.

Shi S, Geng Z, Yu X, Hu B, Liu L, Chi Z, Qu L, Zhang M, Jin Y
Genes 2023 Aug 30;14(9)

Knockdown of long noncoding RNA SAN rejuvenates aged adipose-derived stem cells via miR-143-3p/ADD3 axis.

Xiong H, Ren S, Chen J, Yang X, Liu Y, Xu Z, Guo J, Jiang T, Yuan M, Liu Y, Zhang G, Li W, Machens HG, Chen Z
Stem cell research & therapy 2023 Aug 21;14(1):213

NRF1-mediated mitochondrial biogenesis antagonizes innate antiviral immunity.

Zhao T, Zhang J, Lei H, Meng Y, Cheng H, Zhao Y, Geng G, Mu C, Chen L, Liu Q, Luo Q, Zhang C, Long Y, Su J, Wang Y, Li Z, Sun J, Chen G, Li Y, Liao X, Shang Y, Hu G, Chen Q, Zhu Y
The EMBO journal 2023 Aug 15;42(16):e113258

Aristolochic acid induces an inflammatory response with prostaglandin E2 production and apoptosis in NRK-52E proximal tubular cells.

Komatsu M, Funakoshi T, Aki T, Unuma K, Uemura K
Toxicology letters 2023 Apr 1;378:39-50

Senescent renal tubular epithelial cells activate fibroblasts by secreting Shh to promote the progression of diabetic kidney disease.

Wang D, Yin L, Chen R, Tan W, Liang L, Xiang J, Zhang H, Zhou X, Deng H, Guo B, Wang Y
Frontiers in medicine 2022;9:1018298

HJURP Promotes Malignant Progression and Mediates Sensitivity to Cisplatin and WEE1-inhibitor in Serous Ovarian Cancer.

Dou Z, Qiu C, Zhang X, Yao S, Zhao C, Wang Z, Chu R, Chen J, Chen Z, Li R, Wang K, Liu P, Liu C, Song K, Kong B
International journal of biological sciences 2022;18(3):1188-1210

Taohong siwu decoction attenuates AIM2 and NLRC4 inflammasomes by ameliorates deoxyribonucleic acid damage after ischemic stroke.

Wang N, Chu F, Zhang L, Fei C, Yu C, Xue S, Wang Y, Fang L, Peng D, Duan X, Chen W
Frontiers in pharmacology 2022;13:954867

Olaparib, a PARP-1 inhibitor, protects retinal cells from ocular hypertension-associated oxidative damage.

Yang Y, Wu J, Lu W, Dai Y, Zhang Y, Sun X
Frontiers in cell and developmental biology 2022;10:925835

AKR1B10 accelerates the production of proinflammatory cytokines via the NF-κB signaling pathway in colon cancer.

Liu C, Shi L, Li W, Huang Z, Wang S, Xu P, Li T, Li Z, Luo F, Li W, Yan J, Wu T
Journal of molecular histology 2022 Oct;53(5):781-791

ITGA2 overexpression inhibits DNA repair and confers sensitivity to radiotherapies in pancreatic cancer.

Zhou C, Li S, Bin K, Qin G, Pan P, Ren D, Zhao Y, Xia W, Chen J, Liu J, Wu H, Zhou Y
Cancer letters 2022 Oct 28;547:215855

Inhibitory effect of tanshinone IIA, resveratrol and silibinin on enterovirus 68 production through inhibiting ATM and DNA-PK pathway.

Su Y, Wu T, Yu XY, Huo WB, Wang SH, Huan C, Liu YM, Liu JM, Cui MN, Li XH, Yu JH
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 May;99:153977

[Effect of WRAP53 β Targeted Co-Inhibitory Pathways Based on Comprehensive Bioinformatics Analysis in Treating Squamous Cell Carcinoma of the Head and Neck].

Yao YF, Liu W, Zhou ML, Qiu TL, Wang K
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 2022 May;53(3):457-465

ChK1 activation induces reactive astrogliosis through CIP2A/PP2A/STAT3 pathway in Alzheimer's disease.

Zhou Y, Liu X, Ma S, Zhang N, Yang D, Wang L, Ye S, Zhang Q, Ruan J, Ma J, Wang S, Jiang N, Zhao Z, Zhao S, Zheng C, Fan X, Gong Y, Abdoul Razak MY, Hu W, Pan J, Wang X, Fan J, Li J, Liu R, Shentu Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Mar;36(3):e22209

A Novel CDK4/6 and PARP Dual Inhibitor ZC-22 Effectively Suppresses Tumor Growth and Improves the Response to Cisplatin Treatment in Breast and Ovarian Cancer.

Tian C, Wei Y, Li J, Huang Z, Wang Q, Lin Y, Lv X, Chen Y, Fan Y, Sun P, Xiang R, Chang A, Yang S
International journal of molecular sciences 2022 Mar 7;23(5)

Combined Inactivation of CTPS1 and ATR Is Synthetically Lethal to MYC-Overexpressing Cancer Cells.

Sun Z, Zhang Z, Wang QQ, Liu JL
Cancer research 2022 Mar 15;82(6):1013-1024

2-Fluorofucose Attenuates Hydrogen Peroxide-Induced Oxidative Stress in HepG2 Cells via Nrf2/keap1 and NF-κB Signaling Pathways.

Tu M, Fan X, Shi J, Jing S, Xu X, Wang Y
Life (Basel, Switzerland) 2022 Mar 11;12(3)

KDM6B promotes PARthanatos via suppression of O6-methylguanine DNA methyltransferase repair and sustained checkpoint response.

Yang M, Wang C, Zhou M, Bao L, Wang Y, Kumar A, Xing C, Luo W, Wang Y
Nucleic acids research 2022 Jun 24;50(11):6313-6331

Minocycline Counteracts Ectopic Calcification in a Murine Model of Pseudoxanthoma Elasticum: A Proof-of-Concept Study.

Bouderlique E, Nollet L, Letavernier E, Vanakker OM
International journal of molecular sciences 2022 Feb 6;23(3)

Heterozygous FMN2 missense variant found in a family case of premature ovarian insufficiency.

Li J, Peng T, Wang L, Long P, Quan R, Tan H, Zeng M, Wu X, Yang J, Xiao H, Shi X
Journal of ovarian research 2022 Feb 28;15(1):31

Regulation of host factor γ-H2AX level and location by enterovirus A71 for viral replication.

Yu J, Zhang W, Huo W, Meng X, Zhong T, Su Y, Liu Y, Liu J, Wang Z, Song F, Zhang S, Li Z, Yu X, Yu X, Hua S
Virulence 2022 Dec;13(1):241-257

PM2.5-Induced Programmed Myocardial Cell Death via mPTP Opening Results in Deteriorated Cardiac Function in HFpEF Mice.

Wu T, Tong M, Chu A, Wu K, Niu X, Zhang Z
Cardiovascular toxicology 2022 Aug;22(8):746-762

Real-world PM(2.5) exposure induces pathological injury and DNA damage associated with miRNAs and DNA methylation alteration in rat lungs.

Zhao L, Zhang M, Bai L, Zhao Y, Cai Z, Yung KKL, Dong C, Li R
Environmental science and pollution research international 2022 Apr;29(19):28788-28803

ACTL6A deficiency induces apoptosis through impairing DNA replication and inhibiting the ATR-Chk1 signaling in glioblastoma cells.

Hu X, Pei D, Ci M, Zhang G, Li B, Wang J, Shen Y, Zhai X, Liang P, Cui H
Biochemical and biophysical research communications 2022 Apr 9;599:148-155

Minimizing adverse effects of Cerenkov radiation induced photodynamic therapy with transformable photosensitizer-loaded nanovesicles.

Qian R, Wang K, Guo Y, Li H, Zhu Z, Huang X, Gong C, Gao Y, Guo R, Yang B, Wang C, Jiang D, Lan X, An R, Gao Z
Journal of nanobiotechnology 2022 Apr 27;20(1):203

Photobiomodulation Therapy Attenuates Anxious-Depressive-Like Behavior in the TgF344 Rat Model.

Yang L, Wu C, Tucker L, Dong Y, Li Y, Xu P, Zhang Q
Journal of Alzheimer's disease : JAD 2021;83(4):1415-1429

The Formation of Melanocyte Apoptotic Bodies in Vitiligo and the Relocation of Vitiligo Autoantigens under Oxidative Stress.

Tian J, Wang Y, Ding M, Zhang Y, Chi J, Wang T, Jiao B, Jian Z, Yi X, Huang Y, Liu L, Li K, Chen J, Wang G, Gao T, Li C, Li Q
Oxidative medicine and cellular longevity 2021;2021:7617839

Ailanthus Altissima-derived Ailanthone enhances Gastric Cancer Cell Apoptosis by Inducing the Repression of Base Excision Repair by Downregulating p23 Expression.

Wang CM, Li HF, Wang XK, Li WG, Su Q, Xiao X, Hao TF, Chen W, Zhang YW, Zhang HY, Wu W, Hu ZR, Zhao GY, Huo MY, He YL, Zhang CH
International journal of biological sciences 2021;17(11):2811-2825

Hedgehog/GLI1 signaling pathway regulates the resistance to cisplatin in human osteosarcoma.

Chen D, Kang X, Li Z, Chen L, Ma Q, Fan P
Journal of Cancer 2021;12(22):6676-6684

Identification of Potential Prognostic Biomarker for Predicting Survival in Multiple Myeloma Using Bioinformatics Analysis and Experiments.

Zhou J, Zhang M, Zhang Y, Shi X, Liu L, Yao R
Frontiers in genetics 2021;12:722132

Stimulation of ROS Generation by Extract of Warburgia ugandensis Leading to G(0)/G(1) Cell Cycle Arrest and Antiproliferation in A549 Cells.

Zhang YL, Chen GL, Liu Y, Zhuang XC, Guo MQ
Antioxidants (Basel, Switzerland) 2021 Sep 30;10(10)

ZMYND8 Expression in Breast Cancer Cells Blocks T-Lymphocyte Surveillance to Promote Tumor Growth.

Wang Y, Luo M, Chen Y, Wang Y, Zhang B, Ren Z, Bao L, Wang Y, Wang JE, Fu YX, Luo W, Wang Y
Cancer research 2021 Jan 1;81(1):174-186

MiR-320b/RAD21 axis affects hepatocellular carcinoma radiosensitivity to ionizing radiation treatment through DNA damage repair signaling.

Wang J, Zhao H, Yu J, Xu X, Jing H, Li N, Tang Y, Wang S, Li Y, Cai J, Jin J
Cancer science 2021 Feb;112(2):575-588

Ginsenoside Rb1 Ameliorates Age-Related Myocardial Dysfunction by Regulating the NF-[Formula: see text]B Signaling Pathway.

Ke SY, Liu DH, Wu L, Yu XG, Wang M, Shi GY, Wen RH, Zhou B, Hao BS, Liu Y, Zhu JM, Qian XX
The American journal of Chinese medicine 2020;48(6):1369-1383

Diethyldithiocarbamate-copper nanocomplex reinforces disulfiram chemotherapeutic efficacy through light-triggered nuclear targeting.

Ren L, Feng W, Shao J, Ma J, Xu M, Zhu BZ, Zheng N, Liu S
Theranostics 2020;10(14):6384-6398

Telomere dysfunction activates YAP1 to drive tissue inflammation.

Chakravarti D, Hu B, Mao X, Rashid A, Li J, Li J, Liao WT, Whitley EM, Dey P, Hou P, LaBella KA, Chang A, Wang G, Spring DJ, Deng P, Zhao D, Liang X, Lan Z, Lin Y, Sarkar S, Terranova C, Deribe YL, Blutt SE, Okhuysen P, Zhang J, Vilar E, Nielsen OH, Dupont A, Younes M, Patel KR, Shroyer NF, Rai K, Estes MK, Wang YA, Bertuch AA, DePinho RA
Nature communications 2020 Sep 21;11(1):4766

CHK1 monitors spindle assembly checkpoint and DNA damage repair during the first cleavage of mouse early embryos.

Ju JQ, Li XH, Pan MH, Xu Y, Sun MH, Xu Y, Sun SC
Cell proliferation 2020 Oct;53(10):e12895

DNA methylation‑regulated miR‑155‑5p depresses sensitivity of esophageal carcinoma cells to radiation and multiple chemotherapeutic drugs via suppression of MAP3K10.

Luo W, Zhang H, Liang X, Xia R, Deng H, Yi Q, Lv L, Qian L
Oncology reports 2020 May;43(5):1692-1704

A novel lncRNA PLK4 up-regulated by talazoparib represses hepatocellular carcinoma progression by promoting YAP-mediated cell senescence.

Jia Y, Jin H, Gao L, Yang X, Wang F, Ding H, Chen A, Tan S, Zhang F, Shao J, Wang S, Zheng S
Journal of cellular and molecular medicine 2020 May;24(9):5304-5316

A Heterojunction Structured WO(2.9)-WSe(2) Nanoradiosensitizer Increases Local Tumor Ablation and Checkpoint Blockade Immunotherapy upon Low Radiation Dose.

Dong X, Cheng R, Zhu S, Liu H, Zhou R, Zhang C, Chen K, Mei L, Wang C, Su C, Liu X, Gu Z, Zhao Y
ACS nano 2020 May 26;14(5):5400-5416

Promotion effects of mono-2-ethyhexyl phthalate (MEHP) on migration and invasion of human melanoma cells via activation of TGF-β signals.

Fan P, Li Z, Zuo C, Fang M
Cell biochemistry and function 2020 Jan;38(1):38-46

5-(3,4,5-trimethoxybenzoyl)-4-methyl-2-(p-tolyl) imidazol (BZML) targets tubulin and DNA to induce anticancer activity and overcome multidrug resistance in colorectal cancer cells.

Bai Z, Liu X, Guan Q, Ding N, Wei Q, Tong B, Zhao M, Zhang W, Ma L
Chemico-biological interactions 2020 Jan 5;315:108886

β-Elemene enhances radiosensitivity in non-small-cell lung cancer by inhibiting epithelial-mesenchymal transition and cancer stem cell traits via Prx-1/NF-kB/iNOS signaling pathway.

Zou K, Li Z, Zhang Y, Mu L, Chen M, Wang R, Deng W, Zou L, Liu J
Aging 2020 Dec 9;13(2):2575-2592

Progerin accumulation in nucleus pulposus cells impairs mitochondrial function and induces intervertebral disc degeneration and therapeutic effects of sulforaphane.

Xu X, Wang D, Zheng C, Gao B, Fan J, Cheng P, Liu B, Yang L, Luo Z
Theranostics 2019;9(8):2252-2267

Mouse Model of Mutated in Colorectal Cancer Gene Deletion Reveals Novel Pathways in Inflammation and Cancer.

Currey N, Jahan Z, Caldon CE, Tran PN, Benthani F, De Lacavalerie P, Roden DL, Gloss BS, Campos C, Bean EG, Bullman A, Reibe-Pal S, Dinger ME, Febbraio MA, Clarke SJ, Dahlstrom JE, Kohonen-Corish MRJ
Cellular and molecular gastroenterology and hepatology 2019;7(4):819-839

EBV encoded miRNA BART8-3p promotes radioresistance in nasopharyngeal carcinoma by regulating ATM/ATR signaling pathway.

Zhou X, Zheng J, Tang Y, Lin Y, Wang L, Li Y, Liu C, Wu D, Cai L
Bioscience reports 2019 Sep 30;39(9)

Conditioned medium derived from human amniotic stem cells delays H2O2‑induced premature senescence in human dermal fibroblasts.

Pan C, Lang H, Zhang T, Wang R, Lin X, Shi P, Zhao F, Pang X
International journal of molecular medicine 2019 Nov;44(5):1629-1640

Tumor microenvironment-manipulated radiocatalytic sensitizer based on bismuth heteropolytungstate for radiotherapy enhancement.

Zhou R, Wang H, Yang Y, Zhang C, Dong X, Du J, Yan L, Zhang G, Gu Z, Zhao Y
Biomaterials 2019 Jan;189:11-22

Extremely Effective Chemoradiotherapy by Inducing Immunogenic Cell Death and Radio-Triggered Drug Release under Hypoxia Alleviation.

Zhu C, Guo X, Luo L, Wu Z, Luo Z, Jiang M, Zhang J, Qin B, Shi Y, Lou Y, Qiu Y, You J
ACS applied materials & interfaces 2019 Dec 18;11(50):46536-46547

Single-Cell RNA Transcriptome Helps Define the Limbal/Corneal Epithelial Stem/Early Transit Amplifying Cells and How Autophagy Affects This Population.

Kaplan N, Wang J, Wray B, Patel P, Yang W, Peng H, Lavker RM
Investigative ophthalmology & visual science 2019 Aug 1;60(10):3570-3583

Morroniside regulates hair growth and cycle transition via activation of the Wnt/β-catenin signaling pathway.

Zhou L, Wang H, Jing J, Yu L, Wu X, Lu Z
Scientific reports 2018 Sep 13;8(1):13785

Histone methylation regulates Hif-1 signaling cascade in activation of hepatic stellate cells.

Hong F, Wan L, Liu J, Huang K, Xiao Z, Zhang Y, Shi C
FEBS open bio 2018 Mar;8(3):406-415

Lead Induces Genotoxicity via Oxidative Stress and Promoter Methylation of DNA Repair Genes in Human Lymphoblastoid TK6 Cells.

Liu X, Wu J, Shi W, Shi W, Liu H, Wu X
Medical science monitor : international medical journal of experimental and clinical research 2018 Jun 22;24:4295-4304

The Glycosylphosphatidylinositol Transamidase Complex Subunit PbGPI16 of Plasmodium berghei Is Important for Inducing Experimental Cerebral Malaria.

Liu Q, Zhao Y, Zheng L, Zhu X, Cui L, Cao Y
Infection and immunity 2018 Aug;86(8)

Radiosensitizing effects of miR-18a-5p on lung cancer stem-like cells via downregulating both ATM and HIF-1α.

Chen X, Wu L, Li D, Xu Y, Zhang L, Niu K, Kong R, Gu J, Xu Z, Chen Z, Sun J
Cancer medicine 2018 Aug;7(8):3834-3847

Overcoming resistance to mitochondrial apoptosis by BZML-induced mitotic catastrophe is enhanced by inhibition of autophagy in A549/Taxol cells.

Bai Z, Gao M, Xu X, Zhang H, Xu J, Guan Q, Wang Q, Du J, Li Z, Zuo D, Zhang W, Wu Y
Cell proliferation 2018 Aug;51(4):e12450

Role of Peroxiredoxin 2 in the Protection Against Ferrous Sulfate-Induced Oxidative and Inflammatory Injury in PC12 Cells.

Xu W, Li F, Xu Z, Sun B, Cao J, Liu Y
Cellular and molecular neurobiology 2018 Apr;38(3):735-745

MiR-20a-5p promotes radio-resistance by targeting Rab27B in nasopharyngeal cancer cells.

Huang D, Bian G, Pan Y, Han X, Sun Y, Wang Y, Shen G, Cheng M, Fang X, Hu S
Cancer cell international 2017;17:32

Oxidative stress contributes to hepatocyte growth factor-dependent pro-senescence activity of ovarian cancer cells.

Mikuła-Pietrasik J, Uruski P, Pakuła M, Maksin K, Szubert S, Woźniak A, Naumowicz E, Szpurek D, Tykarski A, Książek K
Free radical biology & medicine 2017 Sep;110:270-279

Quercetin exerts synergetic anti-cancer activity with 10-hydroxy camptothecin.

Tang Q, Ji F, Wang J, Guo L, Li Y, Bao Y
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2017 Nov 15;109:223-232

The chromatin remodeler Chd4 maintains embryonic stem cell identity by controlling pluripotency- and differentiation-associated genes.

Zhao H, Han Z, Liu X, Gu J, Tang F, Wei G, Jin Y
The Journal of biological chemistry 2017 May 19;292(20):8507-8519

Anthocyanins from Black Chokeberry (Aroniamelanocarpa Elliot) Delayed Aging-Related Degenerative Changes of Brain.

Wei J, Zhang G, Zhang X, Xu D, Gao J, Fan J, Zhou Z
Journal of agricultural and food chemistry 2017 Jul 26;65(29):5973-5984

Polyoxometalate-Based Radiosensitization Platform for Treating Hypoxic Tumors by Attenuating Radioresistance and Enhancing Radiation Response.

Yong Y, Zhang C, Gu Z, Du J, Guo Z, Dong X, Xie J, Zhang G, Liu X, Zhao Y
ACS nano 2017 Jul 25;11(7):7164-7176

Anthocyanins Delay Ageing-Related Degenerative Changes in the Liver.

Wei J, Zhang G, Zhang X, Xu D, Gao J, Fan J
Plant foods for human nutrition (Dordrecht, Netherlands) 2017 Dec;72(4):425-431

Tert-butylhydroquinone protects PC12 cells against ferrous sulfate-induced oxidative and inflammatory injury via the Nrf2/ARE pathway.

Xu W, Li F, Xu Z, Sun B, Cao J, Liu Y
Chemico-biological interactions 2017 Aug 1;273:28-36

Novel recombinant protein FlaA N/C increases tumor radiosensitivity via NF-κB signaling in murine breast cancer cells.

Xu Y, Wu D, Fan Y, Li P, Du H, Shi J, Wang D, Zhou X
Oncology letters 2016 Oct;12(4):2632-2640

XAB2 functions in mitotic cell cycle progression via transcriptional regulation of CENPE.

Hou S, Li N, Zhang Q, Li H, Wei X, Hao T, Li Y, Azam S, Liu C, Cheng W, Jin B, Liu Q, Li M, Lei H
Cell death & disease 2016 Oct 13;7(10):e2409

Novel Recombinant Protein FlaA N/C Protects against Radiation Injury via NF-κB Signaling.

Xu Y, Wu D, Fan Y, Li P, Du H, Shi J, Wang D, Zhou X
Radiation research 2016 Jan;185(1):77-86

Nuclear PTEN interferes with binding of Ku70 at double-strand breaks through post-translational poly(ADP-ribosyl)ation.

Guan J, Zhao Q, Mao W
Biochimica et biophysica acta 2016 Dec;1863(12):3106-3115

Oxaliplatin triggers necrosis as well as apoptosis in gastric cancer SGC-7901 cells.

Wu P, Zhu X, Jin W, Hao S, Liu Q, Zhang L
Biochemical and biophysical research communications 2015 May 1;460(2):183-90

BRG1 promotes the repair of DNA double-strand breaks by facilitating the replacement of RPA with RAD51.

Qi W, Wang R, Chen H, Wang X, Xiao T, Boldogh I, Ba X, Han L, Zeng X
Journal of cell science 2015 Jan 15;128(2):317-30

Oncogenic miR-17/20a Forms a Positive Feed-forward Loop with the p53 Kinase DAPK3 to Promote Tumorigenesis.

Cai Z, Cao R, Zhang K, Xue Y, Zhang C, Zhou Y, Zhou J, Sun H, Fu XD
The Journal of biological chemistry 2015 Aug 7;290(32):19967-75

Oncogene-triggered suppression of DNA repair leads to DNA instability in cancer.

Yaglom JA, McFarland C, Mirny L, Sherman MY
Oncotarget 2014 Sep 30;5(18):8367-78

Hypoxia-inducible factor-1alpha and MAPK co-regulate activation of hepatic stellate cells upon hypoxia stimulation.

Wang Y, Huang Y, Guan F, Xiao Y, Deng J, Chen H, Chen X, Li J, Huang H, Shi C
PloS one 2013;8(9):e74051

Prosaposin, a regulator of estrogen receptor alpha, promotes breast cancer growth.

Wu Y, Sun L, Zou W, Xu J, Liu H, Wang W, Yun X, Gu J
Cancer science 2012 Oct;103(10):1820-5

Aberrant survivin expression in endometrial hyperplasia: another mechanism of progestin resistance.

Chen X, Zhang Z, Feng Y, Fadare O, Wang J, Ai Z, Jin H, Gu C, Zheng W
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2009 May;22(5):699-708

H2AX: functional roles and potential applications.

Dickey JS, Redon CE, Nakamura AJ, Baird BJ, Sedelnikova OA, Bonner WM
Chromosoma 2009 Dec;118(6):683-92

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Raji cells were subjected to SDS PAGE followed by western blot with 10856-1-AP(H2AFX antibody) at dilution of 1:1000
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of HepG2 cells, using H2AFX antibody 10856-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human lymphoma using 10856-1-AP(H2AFX antibody) at dilution of 1:100 (under 10x lens)
Sample type: tissue