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- Product number
- ABIN250668 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-gamma Histone Variant H2AX (GAMMA-H2AX) (C-Term), (pSer139) antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Epitope
- pSer139, C-Term
- Isotype
- IgG
- Vial size
- 0.1 mL
- Storage
- Store at 4°C. Do not freeze.
- Handling
- Do not freeze.
Submitted references Establishment and characterization of a canine soft tissue sarcoma patient-derived xenograft model.
Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression.
Lurbinectedin induces depletion of tumor-associated macrophages, an essential component of its in vivo synergism with gemcitabine, in pancreatic adenocarcinoma mouse models.
The polarity protein Scrib mediates epidermal development and exerts a tumor suppressive function during skin carcinogenesis.
Fibulin-5 Blocks Microenvironmental ROS in Pancreatic Cancer.
Increased expression of stathmin and elongation factor 1α in precancerous nodules with telomere dysfunction in hepatitis B viral cirrhotic patients.
PinX1, a telomere repeat-binding factor 1 (TRF1)-interacting protein, maintains telomere integrity by modulating TRF1 homeostasis, the process in which human telomerase reverse Transcriptase (hTERT) plays dual roles.
Wee1 inhibition by MK-1775 leads to tumor inhibition and enhances efficacy of gemcitabine in human sarcomas.
E2F7 represses a network of oscillating cell cycle genes to control S-phase progression.
Mutant telomerase RNAs induce DNA damage and apoptosis via the TRF2-ATM pathway in telomerase-overexpressing primary fibroblasts.
Loss of fibulin-5 binding to beta1 integrins inhibits tumor growth by increasing the level of ROS.
Chemopreventive agent 3,3'-diindolylmethane selectively induces proteasomal degradation of class I histone deacetylases.
Potentiation of temozolomide cytotoxicity by inhibition of DNA polymerase beta is accentuated by BRCA2 mutation.
Dual phosphoinositide 3-kinase/mammalian target of rapamycin blockade is an effective radiosensitizing strategy for the treatment of non-small cell lung cancer harboring K-RAS mutations.
Frazier JP, Beirne E, Ditzler SH, Tretyak I, Casalini JR, Thirstrup DJ, Knoblaugh S, Ward JG, Tripp CD, Klinghoffer RA
Veterinary and comparative oncology 2017 Sep;15(3):754-763
Veterinary and comparative oncology 2017 Sep;15(3):754-763
Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression.
Franz A, Pirson PA, Pilger D, Halder S, Achuthankutty D, Kashkar H, Ramadan K, Hoppe T
Nature communications 2016 Feb 4;7:10612
Nature communications 2016 Feb 4;7:10612
Lurbinectedin induces depletion of tumor-associated macrophages, an essential component of its in vivo synergism with gemcitabine, in pancreatic adenocarcinoma mouse models.
Céspedes MV, Guillén MJ, López-Casas PP, Sarno F, Gallardo A, Álamo P, Cuevas C, Hidalgo M, Galmarini CM, Allavena P, Avilés P, Mangues R
Disease models & mechanisms 2016 Dec 1;9(12):1461-1471
Disease models & mechanisms 2016 Dec 1;9(12):1461-1471
The polarity protein Scrib mediates epidermal development and exerts a tumor suppressive function during skin carcinogenesis.
Pearson HB, McGlinn E, Phesse TJ, Schlüter H, Srikumar A, Gödde NJ, Woelwer CB, Ryan A, Phillips WA, Ernst M, Kaur P, Humbert P
Molecular cancer 2015 Sep 17;14:169
Molecular cancer 2015 Sep 17;14:169
Fibulin-5 Blocks Microenvironmental ROS in Pancreatic Cancer.
Wang M, Topalovski M, Toombs JE, Wright CM, Moore ZR, Boothman DA, Yanagisawa H, Wang H, Witkiewicz A, Castrillon DH, Brekken RA
Cancer research 2015 Dec 1;75(23):5058-69
Cancer research 2015 Dec 1;75(23):5058-69
Increased expression of stathmin and elongation factor 1α in precancerous nodules with telomere dysfunction in hepatitis B viral cirrhotic patients.
Ahn EY, Yoo JE, Rhee H, Kim MS, Choi J, Ko JE, Lee JS, Park YN
Journal of translational medicine 2014 May 31;12:154
Journal of translational medicine 2014 May 31;12:154
PinX1, a telomere repeat-binding factor 1 (TRF1)-interacting protein, maintains telomere integrity by modulating TRF1 homeostasis, the process in which human telomerase reverse Transcriptase (hTERT) plays dual roles.
Yoo JE, Park YN, Oh BK
The Journal of biological chemistry 2014 Mar 7;289(10):6886-98
The Journal of biological chemistry 2014 Mar 7;289(10):6886-98
Wee1 inhibition by MK-1775 leads to tumor inhibition and enhances efficacy of gemcitabine in human sarcomas.
Kreahling JM, Foroutan P, Reed D, Martinez G, Razabdouski T, Bui MM, Raghavan M, Letson D, Gillies RJ, Altiok S
PloS one 2013;8(3):e57523
PloS one 2013;8(3):e57523
E2F7 represses a network of oscillating cell cycle genes to control S-phase progression.
Westendorp B, Mokry M, Groot Koerkamp MJ, Holstege FC, Cuppen E, de Bruin A
Nucleic acids research 2012 Apr;40(8):3511-23
Nucleic acids research 2012 Apr;40(8):3511-23
Mutant telomerase RNAs induce DNA damage and apoptosis via the TRF2-ATM pathway in telomerase-overexpressing primary fibroblasts.
Mahalingam D, Tay LL, Tan WH, Chai JH, Wang X
The FEBS journal 2011 Oct;278(19):3724-38
The FEBS journal 2011 Oct;278(19):3724-38
Loss of fibulin-5 binding to beta1 integrins inhibits tumor growth by increasing the level of ROS.
Schluterman MK, Chapman SL, Korpanty G, Ozumi K, Fukai T, Yanagisawa H, Brekken RA
Disease models & mechanisms 2010 May-Jun;3(5-6):333-42
Disease models & mechanisms 2010 May-Jun;3(5-6):333-42
Chemopreventive agent 3,3'-diindolylmethane selectively induces proteasomal degradation of class I histone deacetylases.
Li Y, Li X, Guo B
Cancer research 2010 Jan 15;70(2):646-54
Cancer research 2010 Jan 15;70(2):646-54
Potentiation of temozolomide cytotoxicity by inhibition of DNA polymerase beta is accentuated by BRCA2 mutation.
Stachelek GC, Dalal S, Donigan KA, Campisi Hegan D, Sweasy JB, Glazer PM
Cancer research 2010 Jan 1;70(1):409-17
Cancer research 2010 Jan 1;70(1):409-17
Dual phosphoinositide 3-kinase/mammalian target of rapamycin blockade is an effective radiosensitizing strategy for the treatment of non-small cell lung cancer harboring K-RAS mutations.
Konstantinidou G, Bey EA, Rabellino A, Schuster K, Maira MS, Gazdar AF, Amici A, Boothman DA, Scaglioni PP
Cancer research 2009 Oct 1;69(19):7644-52
Cancer research 2009 Oct 1;69(19):7644-52
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