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- Antigen structure
- References [18]
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- Product number
- 21668-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#21668-1-AP, RRID:AB_10793724
- Product name
- SESN1 antibody
- Antibody type
- Polyclonal
- Description
- SESN1 antibody (Cat. #21668-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Overexpression of SESN1 improves mitochondrial damage and mitophagy, a potential therapeutic strategy for cognitive dysfunction after anaesthesia.
Resistance exercise preconditioning prevents disuse muscle atrophy by inhibiting apoptosis and protein degradation via SESN2 in C57BL/6J mice.
Exercise ameliorates chronic inflammatory response induced by high-fat diet via Sestrin2 in an Nrf2-dependent manner.
Ring domains are essential for GATOR2-dependent mTORC1 activation.
Tyrosine Is a Booster of Leucine-Induced Muscle Anabolic Response.
Effects of Leucine Ingestion and Contraction on the Sestrin/GATOR2 Pathway and mTORC1 Activation in Rat Fast-Twitch muscle.
Zonated leucine sensing by Sestrin-mTORC1 in the liver controls the response to dietary leucine.
Exercise improves lipid metabolism disorders induced by high-fat diet in a SESN2/JNK-independent manner.
Inhibition of mTORC1 through ATF4-induced REDD1 and Sestrin2 expression by Metformin.
SAR1B senses leucine levels to regulate mTORC1 signalling.
Pentamethylquercetin Attenuates Cardiac Remodeling via Activation of the Sestrins/Keap1/Nrf2 Pathway in MSG-Induced Obese Mice.
Evidence for a role for Sestrin1 in mediating leucine-induced activation of mTORC1 in skeletal muscle.
Sestrin-Mediated Inhibition of Stress-Induced Intervertebral Disc Degradation Through the Enhancement of Autophagy.
Repressors of mTORC1 act to blunt the anabolic response to feeding in the soleus muscle of a cast-immobilized mouse hindlimb.
Exercise improves glucose uptake in murine myotubes through the AMPKα2-mediated induction of Sestrins.
Defective interplay between mTORC1 activity and endoplasmic reticulum stress-unfolded protein response in uremic vascular calcification.
Suppression of Sestrins in aging and osteoarthritic cartilage: dysfunction of an important stress defense mechanism.
Sestrin 3 protein enhances hepatic insulin sensitivity by direct activation of the mTORC2-Akt signaling.
Sun L, Hong X, Wang D, Li Y
The European journal of neuroscience 2024 Jan;59(2):208-219
The European journal of neuroscience 2024 Jan;59(2):208-219
Resistance exercise preconditioning prevents disuse muscle atrophy by inhibiting apoptosis and protein degradation via SESN2 in C57BL/6J mice.
Huang Y, Jiang C, Li X, Liu S, Niu Y, Fu L
Biochimica et biophysica acta. Molecular basis of disease 2024 Apr;1870(4):167111
Biochimica et biophysica acta. Molecular basis of disease 2024 Apr;1870(4):167111
Exercise ameliorates chronic inflammatory response induced by high-fat diet via Sestrin2 in an Nrf2-dependent manner.
Liu S, Li H, Zhang Y, Song H, Fu L
Biochimica et biophysica acta. Molecular basis of disease 2023 Oct;1869(7):166792
Biochimica et biophysica acta. Molecular basis of disease 2023 Oct;1869(7):166792
Ring domains are essential for GATOR2-dependent mTORC1 activation.
Jiang C, Dai X, He S, Zhou H, Fang L, Guo J, Liu S, Zhang T, Pan W, Yu H, Fu T, Li D, Inuzuka H, Wang P, Xiao J, Wei W
Molecular cell 2023 Jan 5;83(1):74-89.e9
Molecular cell 2023 Jan 5;83(1):74-89.e9
Tyrosine Is a Booster of Leucine-Induced Muscle Anabolic Response.
Tamura K, Kitazawa H, Sugita S, Hashizume K, Iwashita M, Ishigami T, Minegishi Y, Shimotoyodome A, Ota N
Nutrients 2023 Dec 26;16(1)
Nutrients 2023 Dec 26;16(1)
Effects of Leucine Ingestion and Contraction on the Sestrin/GATOR2 Pathway and mTORC1 Activation in Rat Fast-Twitch muscle.
Kanzaki K, Wada M
The Journal of nutrition 2023 Aug;153(8):2228-2236
The Journal of nutrition 2023 Aug;153(8):2228-2236
Zonated leucine sensing by Sestrin-mTORC1 in the liver controls the response to dietary leucine.
Cangelosi AL, Puszynska AM, Roberts JM, Armani A, Nguyen TP, Spinelli JB, Kunchok T, Wang B, Chan SH, Lewis CA, Comb WC, Bell GW, Helman A, Sabatini DM
Science (New York, N.Y.) 2022 Jul;377(6601):47-56
Science (New York, N.Y.) 2022 Jul;377(6601):47-56
Exercise improves lipid metabolism disorders induced by high-fat diet in a SESN2/JNK-independent manner.
Wang T, Hu W, Niu Y, Liu S, Fu L
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 2021 Nov;46(11):1322-1330
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 2021 Nov;46(11):1322-1330
Inhibition of mTORC1 through ATF4-induced REDD1 and Sestrin2 expression by Metformin.
Jang SK, Hong SE, Lee DH, Kim JY, Kim JY, Ye SK, Hong J, Park IC, Jin HO
BMC cancer 2021 Jul 12;21(1):803
BMC cancer 2021 Jul 12;21(1):803
SAR1B senses leucine levels to regulate mTORC1 signalling.
Chen J, Ou Y, Luo R, Wang J, Wang D, Guan J, Li Y, Xia P, Chen PR, Liu Y
Nature 2021 Aug;596(7871):281-284
Nature 2021 Aug;596(7871):281-284
Pentamethylquercetin Attenuates Cardiac Remodeling via Activation of the Sestrins/Keap1/Nrf2 Pathway in MSG-Induced Obese Mice.
Du J, He W, Zhang C, Wu J, Li Z, Wang M, Feng S, Liang G
BioMed research international 2020;2020:3243906
BioMed research international 2020;2020:3243906
Evidence for a role for Sestrin1 in mediating leucine-induced activation of mTORC1 in skeletal muscle.
Xu D, Shimkus KL, Lacko HA, Kutzler L, Jefferson LS, Kimball SR
American journal of physiology. Endocrinology and metabolism 2019 May 1;316(5):E817-E828
American journal of physiology. Endocrinology and metabolism 2019 May 1;316(5):E817-E828
Sestrin-Mediated Inhibition of Stress-Induced Intervertebral Disc Degradation Through the Enhancement of Autophagy.
Tu J, Li W, Li S, Liu W, Zhang Y, Wu X, Luo R, Hua W, Wang K, Song Y, Kang L, Yang W, Yang S, Yang C
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;45(5):1940-1954
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;45(5):1940-1954
Repressors of mTORC1 act to blunt the anabolic response to feeding in the soleus muscle of a cast-immobilized mouse hindlimb.
Shimkus KL, Jefferson LS, Gordon BS, Kimball SR
Physiological reports 2018 Oct;6(20):e13891
Physiological reports 2018 Oct;6(20):e13891
Exercise improves glucose uptake in murine myotubes through the AMPKα2-mediated induction of Sestrins.
Wang T, Niu Y, Liu S, Yuan H, Liu X, Fu L
Biochimica et biophysica acta. Molecular basis of disease 2018 Oct;1864(10):3368-3377
Biochimica et biophysica acta. Molecular basis of disease 2018 Oct;1864(10):3368-3377
Defective interplay between mTORC1 activity and endoplasmic reticulum stress-unfolded protein response in uremic vascular calcification.
Panda DK, Bai X, Sabbagh Y, Zhang Y, Zaun HC, Karellis A, Koromilas AE, Lipman ML, Karaplis AC
American journal of physiology. Renal physiology 2018 Jun 1;314(6):F1046-F1061
American journal of physiology. Renal physiology 2018 Jun 1;314(6):F1046-F1061
Suppression of Sestrins in aging and osteoarthritic cartilage: dysfunction of an important stress defense mechanism.
Shen T, Alvarez-Garcia O, Li Y, Olmer M, Lotz MK
Osteoarthritis and cartilage 2017 Feb;25(2):287-296
Osteoarthritis and cartilage 2017 Feb;25(2):287-296
Sestrin 3 protein enhances hepatic insulin sensitivity by direct activation of the mTORC2-Akt signaling.
Tao R, Xiong X, Liangpunsakul S, Dong XC
Diabetes 2015 Apr;64(4):1211-23
Diabetes 2015 Apr;64(4):1211-23
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The SESN1 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human SESN1. This antibody recognizes human,mouse,rat antigen. The SESN1 antibody has been validated for the following applications: ELISA, WB analysis.
