FNab07759

antibody from FineTest Biotech

Targeting: SESN1 PA26, SEST1

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Antibody Data

Product number

FNab07759

Provider

FineTest Biotech

Product name

SESN1 antibody

Antibody type

Polyclonal

Antigen

Recombinant protein fragment

Description

Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway(PubMed:25263562, PubMed:26449471). This stress-inducible metabolic regulator may also play a role in protection against oxidative and genotoxic stresses(By similarity). May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1(PubMed:23274085). May have an alkylhydroperoxide reductase activity born by the N-terminal domain of the protein(By similarity). Was originally reported to contribute to oxidative stress resistance by reducing PRDX1(PubMed:15105503). However, this could not be confirmed(By similarity).

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Antigen sequence

sestrin 1


Epitope

IgG

Isotype

IgG

Vial size

100¦Ìg

Concentration

Immunogen affinity purified

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)

Handling

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)