20339-1-AP

antibody from Proteintech Group

Targeting: YBX1 BP-8, CSDA2, CSDB, DBPB, MDR-NF1, NSEP-1, NSEP1, YB-1, YB1

Provider product page for 20339-1-AP

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ELISA

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Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [103]
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Validations
Western blot [1]
Immunohistochemistry [2]

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Product number: 20339-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#20339-1-AP, RRID:AB_10665424
Product name: YBX1 antibody
Antibody type: Polyclonal
Description: KD/KO validated YBX1 antibody (Cat. #20339-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

YBX1 protein structure - 20339-1-AP shown in red.

Submitted references PTPN1 Regulation via YBX1-PTBP1 Interaction Promotes Fibroblast Activation and Fibrotic Remodeling in the Lung.

Liu H, Xia C, Zhang Y, Gan Y, Cheng L, Wang X, Chang A, Zhao W, Li B, Wang Y, Li Y, Rosas I, Yang J, Yu G, Wang L
International journal of biological sciences 2026;22(5):2233-2246

Context-specific Angiogenin-mediated tRNA fragments (tDRs) biogenesis shapes the mitochondrial stress response.

Al-Mesitef S, Ando D, Saigasaki T, Sakaguchi Y, Akagi S, Mousa A, Rashad S, Niizuma K
Redox biology 2026 Mar;90:104038

YBX1 promotes angiogenesis after myocardial infarction by stabilizing HIF1α mRNA via m(6)A signaling.

Bi F, Yu T, Liu H, Cao M, He Y, Li J, Wang H, Kong C, Xiao H, Tian H, Liu F, Wu Y, Zhou Y, Shan H
iScience 2026 Mar 20;29(3):114810

Pseudoginsenoside F11 enhances YBX1-mediated transcriptional repression of PRPS2 to inhibit the stemness and pulmonary metastasis of triple- negative breast cancer.

Xu K, Bai Y, Chen H, Liu Y, Liu H, Liu Y, Wan X, Liu Y, Chen Y, Shi Y, Xiang R, Zeng B, Cui Y, Fan Y, Li J, Wang L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158064

The oncogenic role of NSUN2 in lung adenocarcinoma by stabilizing CCT5 mRNA via a YBX1-dependent m5C modification.

Li M, Du N, Tang P
Molecular and cellular biochemistry 2026 Jan;481(1):231-243

YBX1 orchestrates LDHA-mediated metabolic reprogramming and NF-κB activation to drive clear cell renal cell carcinoma progression.

Dong Y, Qiu A, Liu S, Pan Y, Lin T, Wang R, Chen R, Jiang H, Yu Y, Wang Y, Yue D
Cell death & disease 2026 Jan 8;17(1):11

YBX1 Modulated Corneal Neovascularization Induced by Alkali Burn via m5C-Dependent Regulation of the STAT3/HIF-1α/VEGFA Axis.

Yang Z, Yan Y, Deng Q, Gao Y, Mao J, Ke L, Wan S, Yang Y
Investigative ophthalmology & visual science 2026 Feb 2;67(2):42

Tet2 deficiency-induced expansion of monocyte-derived macrophages promotes liver fibrosis.

Feng J, Wu B, Li Y, Sun P, Liu Q, Xiao Q, Cai JB, Zheng Y, Chen H, Xu Y, Liu Y, Shi GM, Tan L, Shi YG
The Journal of experimental medicine 2026 Feb 2;223(2)

M(5)C-driven stabilization of SERPINB5 promotes cervical cancer progression and chemotherapy resistance.

Liu J, Zhou L, Yao P, Zhang N, Guo X, Chen F, Yang S, Du X, Wang H, Zhou Y, Chen Y, Zhou L
Cell death & disease 2026 Feb 11;17(1):215

ST7 binds YBX1 to suppress MMP14 expression and inhibit metastasis in non-small cell lung cancer.

Qin Y, Chen Y, Cao Q, Zhang B, Wan Y
Cellular signalling 2026 Aug;144:112554

Dietary fiber-derived butyrate ameliorates pulmonary fibrosis by inhibiting YBX1 ubiquitination.

Li M, Pan T, Ma X, Hu X, Jiang J, Zhang Y, Zhang L, Pan X, Wang Y
The Journal of nutritional biochemistry 2026 Apr;150:110210

Uridine metabolism promotes lung adenocarcinoma progression by activating FBL transcription via YBX1.

Wang X, Chen L, Li Y, Chen L, Hao C, Yan Q, Yu S, Zhang C, Li R, Xu B, Yao Y, Song Q
Journal of translational medicine 2026 Apr 15;24(1)

Genome-wide CRISPR screen identified NEK6 as a determinant of sensitivity to CDK4/6 inhibitor in endometrial cancer.

Jian F, Zhu C, Wang Y, Zhou T, Yang C, Feng W
Frontiers in pharmacology 2025;16:1725886

The TMBIM1-YBX1 axis orchestrates MDSC recruitment and immunosuppressive microenvironment in pancreatic cancer.

Tong X, Xiao M, Yang J, Xu J, Wang W, Yu X, Shi S
Theranostics 2025;15(7):2794-2813

Long non-coding RNA PRSS23-AS1 as ceRNA promotes breast cancer progression by regulating EMT via miR-3176 /YBX1 axis.

Huang Y, Feng M, Jiang Y, Wang M, Wang M, Cao Z
Cancer gene therapy 2025 Sep;32(9):1018-1029

ALKBH5-Mediated M(6)A Demethylation of G3BP1 Attenuates Ferroptosis Via Cytoplasmic Retention of YBX1/p53 in Diabetic Myocardial Ischemia-Reperfusion Injury.

Li W, Li W, Leng Y, Xu H, Xia Z, Wang Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(35):e07254

Menin regulates YBX1 nucleus translocation to boost the HKDC1 transcription and affects pancreatic cancer glycolysis.

Ni C, Yang J, Lu Y, Ma H, Hu H, Shi X, He T, Zhang Y, Jin G, Cheng P
iScience 2025 Sep 19;28(9):113245

Targeting the Phosphoinositide 3-Kinase/Protein Kinase B Pathway Suppresses Y-Box Binding Protein 1 Expression and Inhibits Colorectal Cancer Progression.

Shan H, Wang Y, Hu S, Wang Y, Qin R, Zhang N, Tian G, Qiu Z
World journal of oncology 2025 Oct;16(5):487-501

Enhanced 5-methylcytosine methylation of PSD4 facilitates vasculogenic mimicry in breast cancer brain metastases through ferroptotic resistance.

Li M, Cui C, Li J, Zhou J, Chen S, Yan J, Zhang D, Zhang Y, Xie P, Yao Y, Ni F, An M, Zhang W, Fu B
Cellular signalling 2025 Nov;135:112022

Histone Lactylation-Driven Upregulation of VRK1 Expression Promotes Stemness and Proliferation of Glioma Stem Cells.

Li J, Tang C, Zhang X, Xing R, Guo Q
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(44):e03897

Discovery of a novel Genipin derivative targeting YB-1 to enhance the P-glycoprotein-mediated paclitaxel sensitivity of paclitaxel-resistant non-small cell lung cancer.

Deng L, Zhang G, He M, Wang Y, Li J, Xu X, Hao X, Fan Y, Mu S
European journal of medicinal chemistry 2025 Nov 5;297:117910

YBX1 regulation of alveolar type II epithelial cells in idiopathic pulmonary fibrosis: mechanistic insights and small-molecule drug screening.

He Y, Li J, Xie Y, Wu Y, Wang L, Ren J, Zhang Z, Yu T, Jiang S, Shan H, Wu Y, Zhou Y
Journal of translational medicine 2025 Nov 18;23(1):1301

CILP1 interacting with YBX1 promotes hypertrophic scar formation by suppressing PPARs transcription.

Wang J, Du J, Song Y, Tan X, Wu J, Wang T, Shi Y, Xu X, Yu Z, Song B
Cell death & disease 2025 May 9;16(1):371

Aberrant downregulation of Y-box binding protein 1 expression impairs the cell cycle in an m(5)C-dependent manner in human granulosa cells from patients with primary ovarian insufficiency.

Chen Q, Wang S, Zhang M, Xiang Y, Chen Q, Li Z, Song Y, Bai L, Zhu Y
Cellular and molecular life sciences : CMLS 2025 May 21;82(1):206

Loss of MNX1 Sensitizes Tumors to Cytotoxic T Cells by Degradation of PD-L1 mRNA.

Li Z, Chen L, Zhang G, Wang S, Xu E, Teng J, Xu J, Peng F, Min Q, Wang Z, Shao S, Zhao L, Shan B, Wang Y, Zhan Q, Liu X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Mar;12(12):e2403077

piRNA28846 has the potential to be a novel RNA nucleic acid drug for ovarian cancer.

Qin HL, Han Y, Li JQ, Wu QH, Du YP, Li QH, Chen X, Wang YP, Guan X, Sheng XJ, Chen S, Zhao Y
NPJ precision oncology 2025 Mar 8;9(1):65

RNA-targeted proteomics identifies YBX1 as critical for efficient HCMV mRNA translation.

Dickmander RJ, Lenarcic EM, Sears JD, Hale AE, Moorman NJ
Proceedings of the National Academy of Sciences of the United States of America 2025 Mar 11;122(10):e2421155122

circADARB1 enhances ZEB1 expression in an m(6)A-dependent manner to promote the invasion and migration of nasopharyngeal carcinoma.

Wang D, Mendoza JJ, Xiang P, Zhang Y, Tang L, Zhang J, Fan C, Qu H, Wang Y, Peng Z, Zhou M, Xiang B, Guo C, Xiong W, Shi L, Chen P, Zeng Z
International journal of biological macromolecules 2025 Jul;318(Pt 4):145187

5-methylcytosine regulated CCNL2 promotes tumorigenesis and cisplatin resistance of ovarian cancer with therapeutic implications.

Zhang K, Cheng G, Jiang W, Kong B, Yao S, Liu X
Journal of ovarian research 2025 Jul 24;18(1):162

The SOX12-YBX1-LDHA signaling axis drives metastasis in papillary thyroid carcinoma.

Ruan X, Huang Y, Zeng Y, Zhao Z, Tao M, Zhao Z, Wang Y, Xu G, Zhang W, Yu J, Luo W, Wei S, Li X, Gao M, Yu Y, Li P, Zheng X
Cell death & disease 2025 Jul 1;16(1):474

CircSMAD3 represses VSMC phenotype switching and neointima formation via promoting hnRNPA1 ubiquitination degradation.

Mei S, Ma X, Zhou L, Wuyun Q, Cai Z, Yan J, Ding H
Cell proliferation 2025 Jan;58(1):e13742

YBX1 is required for assembly of viral replication complexes of chikungunya virus and replication of multiple alphaviruses.

Li Z-Q, Zhao L-X, Wang S-Y, Hu C-Y, Wang Y-Y, Yang Y
Journal of virology 2025 Feb 25;99(2):e0201524

KAT7-acetylated YBX1 promotes hepatocellular carcinoma proliferation by reprogramming nucleotide metabolism.

Huang H, Ren L, Zhou Y, Chen P, Zhao H, Li S, Wang H, Li X
BMC cancer 2025 Feb 21;25(1):311

Dynamic Arginine Methylation of YBX1 Relay Controls Its Phase Separation and Chemoradiotherapy Resistance in Rectal Cancer.

Shi Y, Wan T, Liu S, Liu H, Zeng Z, Li W, Liang Z, Xiong L, Luo S, Yuan Y, Huang L, Kang L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(46):e02786

Novel m(5)C-dependent post-transcriptional regulation of KIF11 drives lymphatic metastasis in gastric cancer.

Zhang Y, He R, Ye J, Xu X, Gui X, Wu Y, Lin X, Lin X, Chen K
Scientific reports 2025 Dec 29;15(1):44782

BFAR Promotes Neutrophil Infiltration and Immunosuppressive Reprogramming through the PRP19-YBX1 Axis to Induce Immune Evasion in Gastric Cancer.

Ma X, Liu Y, Chen Y, Wang J, Zhang F, Liang W, Zhang P, Zhou Y, Miao B, Fei S, Yamamoto M, Tsukamoto T, Nomura S, Li L, Wang J
Cancer immunology research 2025 Dec 2;13(12):2037-2053

piR-RCC Suppresses Renal Cell Carcinoma Progression by Facilitating YBX-1 Cytoplasm Localization.

Wang R, Li F, Lin Y, Lu Z, Luo W, Xu Z, Zhu Z, Lu Y, Mao X, Li Y, Shen Z, Lu H, Chen Y, Xia L, Wang M, Ding L, Li G
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(30):e14398

N4-Acetylcytidine-Mediated CD2BP2-DT Drives YBX1 Phase Separation to Stabilize CDK1 and Promote Breast Cancer Progression.

Wang H, Zhao B, Zhang J, Hu Q, Zhou L, Zhang Y, Cai Y, Qu Y, Jiang T, Zhang D
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(15):e2411834

o8G-modified circKIAA1797 promotes lung cancer development by inhibiting cuproptosis.

Xu H, Zhao Q, Cai D, Chen X, Zhou X, Gao Y, Wu J, Yuan S, Li D, Zhang R, Peng W, Li G, Nan A
Journal of experimental & clinical cancer research : CR 2025 Apr 2;44(1):110

LINC02167 stabilizes KSR1 mRNA in an m(5)C-dependent manner to regulate the ERK/MAPK signaling pathway and promotes colorectal cancer metastasis.

Qi J, Jiang T, Liu B, Hu Q, Chen J, Ma N, Xu Y, Song H, Song J
Journal of experimental & clinical cancer research : CR 2025 Apr 15;44(1):121

CircPRKCA facilitates esophageal squamous cell carcinoma metastasis via m5C-dependent CSF2 mRNA stabilization.

Wu L, Gu L, Zheng Y, Liu J, Wei Z, Liu F, Li J, Meng L, Sang Y, Sang M, Zhao L, Shan B
Journal of translational medicine 2025 Apr 1;23(1):385

Apolipoprotein L3 inhibits breast cancer proliferation and modulates cell cycle via the P53 pathway.

Yu H, Li S, Li X, Liu Y, Wang Z, Cui M, Jin F, Yu X
Journal of Cancer 2024;15(14):4623-4635

Engineered targeting OIP5 sensitizes bladder cancer to chemotherapy resistance via TRIP12-PPP1CB-YBX1 axis.

Wang X, Guo T, Niu L, Zheng B, Huang W, Xu H, Huang W
Oncogene 2024 Sep;43(38):2850-2867

Autophagy Deficiency Induced by SAT1 Potentiates Tumor Progression in Triple-Negative Breast Cancer.

Tian W, Zhu L, Luo Y, Tang Y, Tan Q, Zou Y, Chen K, Deng X, Tang H, Li H, Cai M, Xie X, Ye F
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Sep;11(36):e2309903

M(6)A-mediated upregulation of lncRNA TUG1 in liver cancer cells regulates the antitumor response of CD8(+) T cells and phagocytosis of macrophages.

Xi Q, Yang G, He X, Zhuang H, Li L, Lin B, Wang L, Wang X, Fang C, Chen Q, Yang Y, Yu Z, Zhang H, Cai W, Li Y, Shen H, Liu L, Zhang R
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Sep;11(34):e2400695

RRM2 promotes liver metastasis of pancreatic cancer by stabilizing YBX1 and activating the TGF-beta pathway.

Du Z, Zhang Q, Xiang X, Li W, Yang Q, Yu H, Liu T
iScience 2024 Oct 18;27(10):110864

YBX1 as a therapeutic target to suppress the LRP1-β-catenin-RRM1 axis and overcome gemcitabine resistance in pancreatic cancer.

Li B, Xing F, Wang J, Wang X, Zhou C, Fan G, Zhuo Q, Ji S, Yu X, Xu X, Qin Y, Li Z
Cancer letters 2024 Oct 10;602:217197

Isthmin-1 promotes growth and progression of colorectal cancer through the interaction with EGFR and YBX-1.

Zhou X, Zhang K, Wang C, Teng Y, Yu P, Cai W, Gao W, Li M, Ding Y, Sun P, Chen F, Wang Y, Ma J, Maeshige N, Ma X, Li Q, Liang X, Zhang Y, Su D
Cancer letters 2024 May 28;590:216868

RNA m(5)C modification upregulates E2F1 expression in a manner dependent on YBX1 phase separation and promotes tumor progression in ovarian cancer.

Liu X, Wei Q, Yang C, Zhao H, Xu J, Mobet Y, Luo Q, Yang D, Zuo X, Chen N, Yang Y, Li L, Wang W, Yu J, Xu J, Liu T, Yi P
Experimental & molecular medicine 2024 Mar;56(3):600-615

CDKL1 potentiates the antitumor efficacy of radioimmunotherapy by binding to transcription factor YBX1 and blocking PD-L1 expression in lung cancer.

Li Z, Xue H, Li J, Zheng Z, Liu Z, Dong X, Wang H, Chen J, Xu S
Journal of experimental & clinical cancer research : CR 2024 Mar 22;43(1):89

The m(6)A modification mediated-lncRNA POU6F2-AS1 reprograms fatty acid metabolism and facilitates the growth of colorectal cancer via upregulation of FASN.

Jiang T, Qi J, Xue Z, Liu B, Liu J, Hu Q, Li Y, Ren J, Song H, Xu Y, Xu T, Fan R, Song J
Molecular cancer 2024 Mar 16;23(1):55

HMGA2 overexpression activates IGF2BP2 to stabilize APLP2 via m6A modification and promote pancreatic cancer progression.

Liu K, Wei C, Yu H, Zhang Q, Du Z
Heliyon 2024 Mar 15;10(5):e27268

Mechanism of Endogenous Peptide PDYBX1 and Precursor Protein YBX1 in Hirschsprung's Disease.

Sun Q, Zhi Z, Wang C, Du C, Tang J, Li H, Tang W
Neuroscience bulletin 2024 Jun;40(6):695-706

Stress-induced TDP-43 nuclear condensation causes splicing loss of function and STMN2 depletion.

Huang WP, Ellis BCS, Hodgson RE, Sanchez Avila A, Kumar V, Rayment J, Moll T, Shelkovnikova TA
Cell reports 2024 Jul 23;43(7):114421

The recruitment of CD8(+) T cells through YBX1 stabilization abrogates tumor intrinsic oncogenic role of MIR155HG in lung adenocarcinoma.

Li R, Zhang Y, Wang A, Feng Y, Zhang T, Wang H, Chen Y, Yu X, Song X, Ding H, Xu L, Dong G, Jiang F
Cell death discovery 2024 Jul 23;10(1):334

CircSMAD3 represses SMAD3 phosphorylation and ameliorates cardiac remodeling by recruiting YBX1.

Mei S, Ma X, Zhou L, Wuyun Q, Wang J, Xiao Q, Wang M, Zhang K, Chen C, Yan J, Ding H
iScience 2024 Jul 19;27(7):110200

SETD8 inhibits apoptosis and ferroptosis of Ewing's sarcoma through YBX1/RAC3 axis.

Chen H, Hu J, Xiong X, Chen H, Liao Q, Lin B, Chen Y, Peng Y, Li Y, Cheng D, Li Z
Cell death & disease 2024 Jul 10;15(7):494

Stabilization of KPNB1 by deubiquitinase USP7 promotes glioblastoma progression through the YBX1-NLGN3 axis.

Li J, Zhang B, Feng Z, An D, Zhou Z, Wan C, Hu Y, Sun Y, Wang Y, Liu X, Wei W, Yang X, Meng J, Che M, Sheng Y, Wu B, Wen L, Huang F, Li Y, Yang K
Journal of experimental & clinical cancer research : CR 2024 Jan 23;43(1):28

LncRNA LY6E-DT and its encoded metastatic-related protein play oncogenic roles via different pathways and promote breast cancer progression.

Liu HT, Gao ZX, Li F, Guo XY, Li CL, Zhang H, Zhao RN, Liu Y, Shi DB, Zhu WJ, Gao P
Cell death and differentiation 2024 Feb;31(2):188-202

Histone methyltransferase WHSC1 cooperate with YBX1 promote glioblastoma progression via regulating PLK1 expression.

Lu S, Zheng Z, Zhu C
Cellular signalling 2024 Dec;124:111471

NSUN2 mediates distinct pathways to regulate enterovirus 71 replication.

Liu L, Chen Z, Zhang K, Hao H, Ma L, Liu H, Yu B, Ding S, Zhang X, Zhu M, Guo X, Liu Y, Liu H, Huang F, Peng K, Guan W
Virologica Sinica 2024 Aug;39(4):574-586

TAGLN2 induces resistance signature ISGs by activating AKT-YBX1 signal with dual pathways and mediates the IFN-related DNA damage resistance in gastric cancer.

Zhuo H, Hou J, Hong Z, Yu S, Peng H, Zhang L, Xie W, Hong X
Cell death & disease 2024 Aug 21;15(8):608

MS0621, a novel small-molecule modulator of Ewing sarcoma chromatin accessibility, interacts with an RNA-associated macromolecular complex and influences RNA splicing.

Vital T, Wali A, Butler KV, Xiong Y, Foster JP 2nd, Marcel SS, McFadden AW, Nguyen VU, Bailey BM, Lamb KN, James LI, Frye SV, Mosely AL, Jin J, Pattenden SG, Davis IJ
Frontiers in oncology 2023;13:1099550

Knockdown of Y-box binding protein 1 induces autophagy in early porcine embryos.

Jiang WJ, Lee SH, Heo G, Chung HJ, Cho ES, Sa SJ, Hochi S, Cui XS
Frontiers in cell and developmental biology 2023;11:1238546

YBX1 as an oncogenic factor in T-cell acute lymphoblastic leukemia.

Li H, Zhang D, Fu Q, Wang S, Wang Z, Zhang X, Chen X, Zhu X, An N, Chen Y, Zhou L, Lu D, Zhao N
Blood advances 2023 Sep 12;7(17):4874-4885

A circular RNA activated by TGFβ promotes tumor metastasis through enhancing IGF2BP3-mediated PDPN mRNA stability.

Li K, Guo J, Ming Y, Chen S, Zhang T, Ma H, Fu X, Wang J, Liu W, Peng Y
Nature communications 2023 Oct 28;14(1):6876

Silencing circSERPINE2 restrains mesenchymal stem cell senescence via the YBX3/PCNA/p21 axis.

Chen F, Wang S, Zeng C, Tang S, Gu H, Wang Z, Li J, Feng P, Zhang Y, Wang P, Wu Y, Shen H
Cellular and molecular life sciences : CMLS 2023 Oct 13;80(11):325

Long non-coding RNA KCND1 protects hearts from hypertrophy by targeting YBX1.

Yang R, Li L, Hou Y, Li Y, Zhang J, Yang N, Zhang Y, Ji W, Yu T, Lv L, Liang H, Li X, Li T, Shan H
Cell death & disease 2023 May 30;14(5):344

The proteome and transcriptome of stress granules and P bodies during human T lymphocyte activation.

Curdy N, Lanvin O, Cerapio JP, Pont F, Tosolini M, Sarot E, Valle C, Saint-Laurent N, Lhuillier E, Laurent C, Fournié JJ, Franchini DM
Cell reports 2023 Mar 28;42(3):112211

Y-box binding protein 1 influences zygotic genome activation by regulating N6-methyladenosine in porcine embryos.

Jiang WJ, Sun MH, Li XH, Lee SH, Heo G, Zhou D, Cui XS
Journal of cellular physiology 2023 Jul;238(7):1592-1604

THOC3 interacts with YBX1 to promote lung squamous cell carcinoma progression through PFKFB4 mRNA modification.

Yu T, Zhang Q, Yu SK, Nie FQ, Zhang ML, Wang Q, Lu KH
Cell death & disease 2023 Jul 27;14(7):475

TET2 is required to suppress mTORC1 signaling through urea cycle with therapeutic potential.

He J, Lin M, Zhang X, Zhang R, Tian T, Zhou Y, Dong W, Yang Y, Sun X, Dai Y, Xu Y, Zhang Z, Xu M, Lei QY, Xu Y, Lv L
Cell discovery 2023 Aug 8;9(1):84

YB-1 is a positive regulator of KLF5 transcription factor in basal-like breast cancer.

Jiang D, Qiu T, Peng J, Li S, Tala, Ren W, Yang C, Wen Y, Chen CH, Sun J, Wu Y, Liu R, Zhou J, Wu K, Liu W, Mao X, Zhou Z, Chen C
Cell death and differentiation 2022 Jun;29(6):1283-1295

CTPS1 promotes malignant progression of triple-negative breast cancer with transcriptional activation by YBX1.

Lin Y, Zhang J, Li Y, Guo W, Chen L, Chen M, Chen X, Zhang W, Jin X, Jiang M, Xiao H, Wang C, Song C, Fu F
Journal of translational medicine 2022 Jan 6;20(1):17

Coordinated post-transcriptional control of oncogene-induced senescence by UNR/CSDE1.

Avolio R, Inglés-Ferrándiz M, Ciocia A, Coll O, Bonnin S, Guitart T, Ribó A, Gebauer F
Cell reports 2022 Jan 11;38(2):110211

TGF-β/YB-1/Atg7 axis promotes the proliferation of hepatic progenitor cells and liver fibrogenesis.

Guo Y, Zhu J, Xu X, Shen B, Shen Z, Li B, Li F, Gu T, Cai X, Dong H, Lu L
Biochimica et biophysica acta. Molecular basis of disease 2022 Jan 1;1868(1):166290

Profiling and functional characterization of maternal mRNA translation during mouse maternal-to-zygotic transition.

Zhang C, Wang M, Li Y, Zhang Y
Science advances 2022 Feb 4;8(5):eabj3967

LncRNA ELF3-AS1 inhibits gastric cancer by forming a negative feedback loop with SNAI2 and regulates ELF3 mRNA stability via interacting with ILF2/ILF3 complex.

Li D, Shen L, Zhang X, Chen Z, Huang P, Huang C, Qin S
Journal of experimental & clinical cancer research : CR 2022 Dec 2;41(1):332

Selective sorting and secretion of hY4 RNA fragments into extracellular vesicles mediated by methylated YBX1 to promote lung cancer progression.

Li C, Wang W, Sun Y, Ni Y, Qin F, Li X, Wang T, Guo M, Sun G
Journal of experimental & clinical cancer research : CR 2022 Apr 11;41(1):136

hTERT Promotes CRC Proliferation and Migration by Recruiting YBX1 to Increase NRF2 Expression.

Gong C, Yang H, Wang S, Liu J, Li Z, Hu Y, Chen Y, Huang Y, Luo Q, Wu Y, Liu E, Xiao Y
Frontiers in cell and developmental biology 2021;9:658101

Flightless I Homolog Reverses Enzalutamide Resistance through PD-L1-Mediated Immune Evasion in Prostate Cancer.

Ruan H, Bao L, Tao Z, Chen K
Cancer immunology research 2021 Jul;9(7):838-852

Effects of Y Box Binding Protein-1 in Progression and Prognosis of Cholangiocarcinoma.

Chen Y, Jiang P, Tian F, Chen G, Peng T, Deng X, Li Z, Huang D, Zhu J, Zhen P, Xie C, Wang S
Journal of investigative surgery : the official journal of the Academy of Surgical Research 2021 Jan;34(1):55-63

Targeting USP47 overcomes tyrosine kinase inhibitor resistance and eradicates leukemia stem/progenitor cells in chronic myelogenous leukemia.

Lei H, Xu HZ, Shan HZ, Liu M, Lu Y, Fang ZX, Jin J, Jing B, Xiao XH, Gao SM, Gao FH, Xia L, Yang L, Liu LG, Wang WW, Liu CX, Tong Y, Wu YZ, Zheng JK, Chen GQ, Zhou L, Wu YL
Nature communications 2021 Jan 4;12(1):51

Long noncoding RNA SNHG6 promotes carcinogenesis by enhancing YBX1-mediated translation of HIF1α in clear cell renal cell carcinoma.

Zhao P, Deng Y, Wu Y, Guo Q, Zhou L, Yang X, Wang C
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Feb;35(2):e21160

Proteomic Profile of Sperm in Infertile Males Reveals Changes in Metabolic Pathways.

Liang J, Zheng Y, Zeng W, Chen L, Yang S, Du P, Wang Y, Yu X, Zhang X
The protein journal 2021 Dec;40(6):929-939

A reciprocal feedback of miR-548ac/YB-1/Snail induces EndMT of HUVECs during acidity microenvironment.

Chen J, Han S, Chen J, Hu P, Zeng Z, Hu Y, Xiong H, Ke Z, Zhang Y, Xu F, Zhao G
Cancer cell international 2021 Dec 20;21(1):692

The long noncoding RNA AATBC promotes breast cancer migration and invasion by interacting with YBX1 and activating the YAP1/Hippo signaling pathway.

Wang M, Dai M, Wang D, Tang T, Xiong F, Xiang B, Zhou M, Li X, Li Y, Xiong W, Li G, Zeng Z, Guo C
Cancer letters 2021 Aug 1;512:60-72

Comparison of proteomic profiles from the testicular tissue of males with impaired and normal spermatogenesis.

Liang J, Zheng Y, Zeng W, Chen L, Yang S, Du P, Wang Y, Yu X, Zhang X
Systems biology in reproductive medicine 2021 Apr;67(2):127-136

Enhanced YB1/EphA2 axis signaling promotes acquired resistance to sunitinib and metastatic potential in renal cell carcinoma.

Ruan H, Li S, Bao L, Zhang X
Oncogene 2020 Sep;39(38):6113-6128

Y-box binding protein 1 acts as a negative regulator of stearoyl CoA desaturase 1 in clear cell renal cell carcinoma.

Jeffords E, Freeman S, Cole B, Root K, Chekouo T, Melvin RG, Bemis L, Simmons GE Jr
Oncology letters 2020 Nov;20(5):165

LncRNA LINC00472 regulates cell stiffness and inhibits the migration and invasion of lung adenocarcinoma by binding to YBX1.

Deng X, Xiong W, Jiang X, Zhang S, Li Z, Zhou Y, Xiang B, Zhou M, Li X, Li G, Zeng Z, Gong Z
Cell death & disease 2020 Nov 3;11(11):945

IMPDH1/YB-1 Positive Feedback Loop Assembles Cytoophidia and Represents a Therapeutic Target in Metastatic Tumors.

Ruan H, Song Z, Cao Q, Ni D, Xu T, Wang K, Bao L, Tong J, Xiao H, Xiao W, Cheng G, Xiong Z, Liang H, Liu D, Wang L, Olivier T, Jane BH, Yang H, Zhang X, Chen K
Molecular therapy : the journal of the American Society of Gene Therapy 2020 May 6;28(5):1299-1313

CircFOXK2 Promotes Growth and Metastasis of Pancreatic Ductal Adenocarcinoma by Complexing with RNA-Binding Proteins and Sponging MiR-942.

Wong CH, Lou UK, Li Y, Chan SL, Tong JH, To KF, Chen Y
Cancer research 2020 Jun 1;80(11):2138-2149

Systematic quantitative analysis of ribosome inventory during nutrient stress.

An H, Ordureau A, Körner M, Paulo JA, Harper JW
Nature 2020 Jul;583(7815):303-309

SWI/SNF complex subunit BAF60a represses hepatic ureagenesis through a crosstalk between YB-1 and PGC-1α.

Zhang W, Dong Z, Xu M, Zhang S, Liu C, Chen S
Molecular metabolism 2020 Feb;32:85-96

Peptidome characterization of ovarian cancer serum and the identification of tumor suppressive peptide ZYX(36-58).

Wang X, Liu G, Sheng N, Zhang M, Pan X, Liu S, Huang K, Cong Y, Xu Q, Jia X, Xu J
Annals of translational medicine 2020 Aug;8(15):925

Long noncoding RNA GAS5 induces abdominal aortic aneurysm formation by promoting smooth muscle apoptosis.

He X, Wang S, Li M, Zhong L, Zheng H, Sun Y, Lai Y, Chen X, Wei G, Si X, Han Y, Huang S, Li X, Liao W, Liao Y, Bin J
Theranostics 2019;9(19):5558-5576

Targeting the YB-1/PD-L1 Axis to Enhance Chemotherapy and Antitumor Immunity.

Tao Z, Ruan H, Sun L, Kuang D, Song Y, Wang Q, Wang T, Hao Y, Chen K
Cancer immunology research 2019 Jul;7(7):1135-1147

PTBP3 contributes to colorectal cancer growth and metastasis via translational activation of HIF-1α.

Hou P, Chen F, Yong H, Lin T, Li J, Pan Y, Jiang T, Li M, Chen Y, Song J, Zheng J, Bai J
Journal of experimental & clinical cancer research : CR 2019 Jul 10;38(1):301

Antiviral Immune Response as a Trigger of FUS Proteinopathy in Amyotrophic Lateral Sclerosis.

Shelkovnikova TA, An H, Skelt L, Tregoning JS, Humphreys IR, Buchman VL
Cell reports 2019 Dec 24;29(13):4496-4508.e4

Stress granules regulate stress-induced paraspeckle assembly.

An H, Tan JT, Shelkovnikova TA
The Journal of cell biology 2019 Dec 2;218(12):4127-4140

YB-1 regulates tiRNA-induced Stress Granule formation but not translational repression.

Lyons SM, Achorn C, Kedersha NL, Anderson PJ, Ivanov P
Nucleic acids research 2016 Aug 19;44(14):6949-60

Methods for the characterization of stress granules in virus infected cells.

Panas MD, Kedersha N, McInerney GM
Methods (San Diego, Calif.) 2015 Nov 15;90:57-64

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: MCF7 cells were subjected to SDS PAGE followed by western blot with 20339-1-AP(YBX1 antibody) at dilution of 1:500
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human placenta using 20339-1-AP(YBX1 antibody) at dilution of 1:100 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The YBX1 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human YBX1. This antibody recognizes human, mouse antigen. The YBX1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 20339-1-AP.pdf

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