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- References [20]
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- Validations
- Western blot [1]
- Immunoprecipitation [1]
- Immunohistochemistry [1]
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- Product number
- 11357-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11357-1-AP, RRID:AB_2092222
- Product name
- DDX1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated DDX1 antibody (Cat. #11357-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references CircInpp5b Ameliorates Renal Interstitial Fibrosis by Promoting the Lysosomal Degradation of DDX1.
DEAD-box helicase 1 inhibited CD8(+) T cell antitumor activity by inducing PD-L1 expression in hepatocellular carcinoma.
Long non-coding RNA LncCplx2 regulates glucose homeostasis and pancreatic β cell function.
The RNA-Splicing Ligase RTCB Promotes Influenza A Virus Replication by Suppressing Innate Immunity via Interaction with RNA Helicase DDX1.
HNRNPU facilitates antibody class-switch recombination through C-NHEJ promotion and R-loop suppression.
Knockdown of ZBTB11 impedes R-loop elimination and increases the sensitivity to cisplatin by inhibiting DDX1 transcription in bladder cancer.
RNA helicase, DDX3X, is actively recruited to sites of DNA damage in live cells.
Genome-wide analysis of pseudogenes reveals HBBP1's human-specific essentiality in erythropoiesis and implication in β-thalassemia.
Nucleocytoplasmic shuttling of Gle1 impacts DDX1 at transcription termination sites.
CircLONP2 enhances colorectal carcinoma invasion and metastasis through modulating the maturation and exosomal dissemination of microRNA-17.
Modulation of RNA Condensation by the DEAD-Box Protein eIF4A.
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
RNA Helicase DDX1 Converts RNA G-Quadruplex Structures into R-Loops to Promote IgH Class Switch Recombination.
DDX1 regulates alternative splicing and insulin secretion in pancreatic β cells.
A Survey of DDX21 Activity During Rev/RRE Complex Formation.
RNA-binding protein DDX1 is responsible for fatty acid-mediated repression of insulin translation.
DEAD box protein DDX1 promotes colorectal tumorigenesis through transcriptional activation of the LGR5 gene.
BEX1 is an RNA-dependent mediator of cardiomyopathy.
RNase L activates the NLRP3 inflammasome during viral infections.
DDX1 is an RNA-dependent ATPase involved in HIV-1 Rev function and virus replication.
Fang X, Tang C, Zeng D, Shan Y, Liu Q, Yin X, Li Y
Biomolecules 2024 May 23;14(6)
Biomolecules 2024 May 23;14(6)
DEAD-box helicase 1 inhibited CD8(+) T cell antitumor activity by inducing PD-L1 expression in hepatocellular carcinoma.
Liu J, Yang T, Luo Y, Ma Z, Yu Z, Zhang L, Liu G, Wen J, Lu G, Zhang G, Zhao Y, Luo W, Li Y, Yang N, Zhou J, Lu Y, Chen S, Zeng X
Cancer science 2024 Mar;115(3):763-776
Cancer science 2024 Mar;115(3):763-776
Long non-coding RNA LncCplx2 regulates glucose homeostasis and pancreatic β cell function.
Wang L, Hu L, Wang X, Geng Z, Wan M, Hao J, Liu H, Fan Y, Xu T, Li Z
Molecular metabolism 2024 Feb;80:101878
Molecular metabolism 2024 Feb;80:101878
The RNA-Splicing Ligase RTCB Promotes Influenza A Virus Replication by Suppressing Innate Immunity via Interaction with RNA Helicase DDX1.
Cao L, Hui X, Xu T, Mao H, Lin X, Huang K, Zhao L, Jin M
Journal of immunology (Baltimore, Md. : 1950) 2023 Sep 15;211(6):1020-1031
Journal of immunology (Baltimore, Md. : 1950) 2023 Sep 15;211(6):1020-1031
HNRNPU facilitates antibody class-switch recombination through C-NHEJ promotion and R-loop suppression.
Refaat AM, Nakata M, Husain A, Kosako H, Honjo T, Begum NA
Cell reports 2023 Mar 28;42(3):112284
Cell reports 2023 Mar 28;42(3):112284
Knockdown of ZBTB11 impedes R-loop elimination and increases the sensitivity to cisplatin by inhibiting DDX1 transcription in bladder cancer.
Chen L, Liu Z, Tang H, Zhou Z, Chen J, Ma Z, Deng M, Li X, Wu Y, Zheng L, Zhou L, Zheng X, Liu Z
Cell proliferation 2022 Dec;55(12):e13325
Cell proliferation 2022 Dec;55(12):e13325
RNA helicase, DDX3X, is actively recruited to sites of DNA damage in live cells.
Cargill MJ, Morales A, Ravishankar S, Warren EH
DNA repair 2021 Jul;103:103137
DNA repair 2021 Jul;103:103137
Genome-wide analysis of pseudogenes reveals HBBP1's human-specific essentiality in erythropoiesis and implication in β-thalassemia.
Ma Y, Liu S, Gao J, Chen C, Zhang X, Yuan H, Chen Z, Yin X, Sun C, Mao Y, Zhou F, Shao Y, Liu Q, Xu J, Cheng L, Yu D, Li P, Yi P, He J, Geng G, Guo Q, Si Y, Zhao H, Li H, Banes GL, Liu H, Nakamura Y, Kurita R, Huang Y, Wang X, Wang F, Fang G, Engel JD, Shi L, Zhang YE, Yu J
Developmental cell 2021 Feb 22;56(4):478-493.e11
Developmental cell 2021 Feb 22;56(4):478-493.e11
Nucleocytoplasmic shuttling of Gle1 impacts DDX1 at transcription termination sites.
Sharma M, Wente SR
Molecular biology of the cell 2020 Oct 1;31(21):2398-2408
Molecular biology of the cell 2020 Oct 1;31(21):2398-2408
CircLONP2 enhances colorectal carcinoma invasion and metastasis through modulating the maturation and exosomal dissemination of microRNA-17.
Han K, Wang FW, Cao CH, Ling H, Chen JW, Chen RX, Feng ZH, Luo J, Jin XH, Duan JL, Li SM, Ma NF, Yun JP, Guan XY, Pan ZZ, Lan P, Xu RH, Xie D
Molecular cancer 2020 Mar 18;19(1):60
Molecular cancer 2020 Mar 18;19(1):60
Modulation of RNA Condensation by the DEAD-Box Protein eIF4A.
Tauber D, Tauber G, Khong A, Van Treeck B, Pelletier J, Parker R
Cell 2020 Feb 6;180(3):411-426.e16
Cell 2020 Feb 6;180(3):411-426.e16
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Pourhaghighi R, Ash PEA, Phanse S, Goebels F, Hu LZM, Chen S, Zhang Y, Wierbowski SD, Boudeau S, Moutaoufik MT, Malty RH, Malolepsza E, Tsafou K, Nathan A, Cromar G, Guo H, Abdullatif AA, Apicco DJ, Becker LA, Gitler AD, Pulst SM, Youssef A, Hekman R, Havugimana PC, White CA, Blum BC, Ratti A, Bryant CD, Parkinson J, Lage K, Babu M, Yu H, Bader GD, Wolozin B, Emili A
Cell systems 2020 Apr 22;10(4):333-350.e14
Cell systems 2020 Apr 22;10(4):333-350.e14
RNA Helicase DDX1 Converts RNA G-Quadruplex Structures into R-Loops to Promote IgH Class Switch Recombination.
Ribeiro de Almeida C, Dhir S, Dhir A, Moghaddam AE, Sattentau Q, Meinhart A, Proudfoot NJ
Molecular cell 2018 May 17;70(4):650-662.e8
Molecular cell 2018 May 17;70(4):650-662.e8
DDX1 regulates alternative splicing and insulin secretion in pancreatic β cells.
Zhong W, Li Z, Zhou M, Xu T, Wang Y
Biochemical and biophysical research communications 2018 Jun 7;500(3):751-757
Biochemical and biophysical research communications 2018 Jun 7;500(3):751-757
A Survey of DDX21 Activity During Rev/RRE Complex Formation.
Hammond JA, Zhou L, Lamichhane R, Chu HY, Millar DP, Gerace L, Williamson JR
Journal of molecular biology 2018 Feb 16;430(4):537-553
Journal of molecular biology 2018 Feb 16;430(4):537-553
RNA-binding protein DDX1 is responsible for fatty acid-mediated repression of insulin translation.
Li Z, Zhou M, Cai Z, Liu H, Zhong W, Hao Q, Cheng D, Hu X, Hou J, Xu P, Xue Y, Zhou Y, Xu T
Nucleic acids research 2018 Dec 14;46(22):12052-12066
Nucleic acids research 2018 Dec 14;46(22):12052-12066
DEAD box protein DDX1 promotes colorectal tumorigenesis through transcriptional activation of the LGR5 gene.
Tanaka K, Ikeda N, Miyashita K, Nuriya H, Hara T
Cancer science 2018 Aug;109(8):2479-2489
Cancer science 2018 Aug;109(8):2479-2489
BEX1 is an RNA-dependent mediator of cardiomyopathy.
Accornero F, Schips TG, Petrosino JM, Gu SQ, Kanisicak O, van Berlo JH, Molkentin JD
Nature communications 2017 Nov 30;8(1):1875
Nature communications 2017 Nov 30;8(1):1875
RNase L activates the NLRP3 inflammasome during viral infections.
Chakrabarti A, Banerjee S, Franchi L, Loo YM, Gale M Jr, Núñez G, Silverman RH
Cell host & microbe 2015 Apr 8;17(4):466-77
Cell host & microbe 2015 Apr 8;17(4):466-77
DDX1 is an RNA-dependent ATPase involved in HIV-1 Rev function and virus replication.
Edgcomb SP, Carmel AB, Naji S, Ambrus-Aikelin G, Reyes JR, Saphire AC, Gerace L, Williamson JR
Journal of molecular biology 2012 Jan 6;415(1):61-74
Journal of molecular biology 2012 Jan 6;415(1):61-74
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 11357-1-AP(DDX1 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-DDX1 (IP:11357-1-AP, 3ug; Detection:11357-1-AP 1:1000) with PC-3 cells lysate 5000ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The DDX1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human DDX1. This antibody recognizes human,mouse,rat antigen. The DDX1 antibody has been validated for the following applications: ELISA, WB, IHC, IP analysis.
