675302

antibody from BioLegend
Targeting: DDX1 DBP-RB
Provider product page for 675302
Western blot
Immunocytochemistry

Antibody data

Product number
675302 - Provider product page
Provider
BioLegend
Proper citation
BioLegend Cat#675302, RRID:AB_2565509
Product name
Purified anti-DDX1
Antibody type
Monoclonal
Antigen
Partial human DDX1 recombinant protein (1-107 a.a.) expressed in E. coli.
Description
DDX1, also known as DEAD box protein retinoblastoma, is a member of the DEAD (Asp-Glu-Ala-Asp)-box RNA helicase family. DDX1 possesses RNA nuclease, binding, unwinding, and ATPase activities, and is thus involved in RNA metabolism, pre-mRNA splicing, translation initiation, and ribosome biogenesis. DDX1 interacts with the Rev protein of HIV-1 and has been shown to be crucial in the viral RNA replication. DDX1 was found to locate to the area of DNA damage induced by ionizing radiation and is implicated to participate in double-strand DNA break repair. DDX1 also acts as a transcriptional coactivator to facilitate NF-κB mediated gene activation. Elevated expression of DDX1 was observed in a number of tumors such as retinoblastoma, neuroblastoma, and testicular carcinoma. The accumulation of DDX1 is associated with cancer metastasis and poor survival.
Reactivity
Human, Mouse
Host
Mouse
Conjugate
Unconjugated
Antibody clone number
9F12B04
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
2°C-8°C
Handling
Ambient RT
DDX1 protein structure - 675302 shown in red.