CABT-L1337

antibody from Creative Diagnostics

Targeting: H3-3B H3.3B, H3F3B

Western blot (Recommended by provider)

ELISA (Recommended by provider)

Antibody Data

Product number

CABT-L1337

Provider

Creative Diagnostics

Product name

Rabbit Anti-Human Histone H3.3 monoclonal antibody, clone SN200

Antibody type

Monoclonal

Description

Histone H3 is one of the four core proteins of the nucleosome, and it is involved in transcription regulation, DNA repair, DNA replication and chromosomal stability. The N-terminal tail of Histone H3 undergoes many post-translational modifications, including phosphorylation, acetylation, multiple methylation, ubiquitination, and ADP-ribosylation to achieve its diverse functions. HistoneH3 is acetylated and deacetylated on N-terminal lysine residues. Acetylation removes the positive charge on the histone, decreasing the interaction with the negatively charged phosphate groups of DNA, and resulting in a more relaxed structure associated with greater levels of gene transcription. Acetylation of histone H3 at lysine 9 (H3K9Ac) is one of the most well-known epigenetic markers enriched in the promoter region of activated genes.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

SN200

Concentration

1 mg/ml

Storage

-20°C, Avoid Freeze/Thaw Cycles