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- Product number
- 55011-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#55011-1-AP, RRID:AB_10859830
- Product name
- HTRA1 antibody
- Antibody type
- Polyclonal
- Description
- HTRA1 antibody (Cat. #55011-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references N-acetyl-l-leucine lowers α-synuclein levels and improves synaptic function in Parkinson's disease models.
Human papillomavirus E7 inhibits immune responses in keratinocytes by activating HTRA1‑mediated mitophagy.
VDAC1 protein derived from extracellular vesicles promotes paclitaxel resistance in gastric cancer through autophagy and mitophagy.
A novel gene edited rat model of cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL).
Comprehensive human proteome profiles across a 50-year lifespan reveal aging trajectories and signatures.
Role of alpha-1 antitrypsin in Bruch's membrane integrity.
Secretome from Magnetically Stimulated Muscle Exhibits Anticancer Potency: Novel Preconditioning Methodology Highlighting HTRA1 Action.
Instrumental variable and colocalization analyses identify endotrophin and HTRA1 as potential therapeutic targets for coronary artery disease.
Contribution of Streptococcus pseudopneumoniae and Streptococcus salivarius to vocal fold mucosal integrity and function.
HtrA3: a promising prognostic biomarker and therapeutic target for head and neck squamous cell carcinoma.
The identification of hub-methylated differentially expressed genes in osteoarthritis patients is based on epigenomic and transcriptomic data.
Inhibiting HIF-1 signaling alleviates HTRA1-induced RPE senescence in retinal degeneration.
Long non-coding RNA lincRNA-erythroid prosurvival (EPS) alleviates cerebral ischemia/reperfusion injury by maintaining high-temperature requirement protein A1 (Htra1) stability through recruiting heterogeneous nuclear ribonucleoprotein L (HNRNPL).
Brief exposure to directionally-specific pulsed electromagnetic fields stimulates extracellular vesicle release and is antagonized by streptomycin: A potential regenerative medicine and food industry paradigm.
The "Matrisome" reveals the characterization of skin keloid microenvironment.
Murine osteoclasts secrete serine protease HtrA1 capable of degrading osteoprotegerin in the bone microenvironment.
High-Temperature Requirement A 1 Causes Photoreceptor Cell Death in Zebrafish Disease Models.
Emodin Alleviates Sodium Taurocholate-Induced Pancreatic Acinar Cell Injury via MicroRNA-30a-5p-Mediated Inhibition of High-Temperature Requirement A/Transforming Growth Factor Beta 1 Inflammatory Signaling.
Proteolytic Degradation and Inflammation Play Critical Roles in Polypoidal Choroidal Vasculopathy.
A frameshift mutation in HTRA1 expands CARASIL syndrome and peripheral small arterial disease to the Chinese population.
Song P, Chen C, Franchini R, Duong B, Wang YZ, Coukos R, Xie Z, Savas JN, Zhou Y, Bertoldi M, Surmeier DJ, Parisiadou L, Krainc D
The Journal of clinical investigation 2026 Mar 2;136(5)
The Journal of clinical investigation 2026 Mar 2;136(5)
Human papillomavirus E7 inhibits immune responses in keratinocytes by activating HTRA1‑mediated mitophagy.
Zhang B, Kong D, Chen S, Sun X, Cheng H
International journal of molecular medicine 2026 Jan;57(1)
International journal of molecular medicine 2026 Jan;57(1)
VDAC1 protein derived from extracellular vesicles promotes paclitaxel resistance in gastric cancer through autophagy and mitophagy.
Bi Y, Wei S, Zhang Z, Wang Y, Wen Y, Wang H, Li K, Zhang C, Wang Y, Zhao L, Sun G
Cancer biology & medicine 2026 Feb 17;23(2):252-75
Cancer biology & medicine 2026 Feb 17;23(2):252-75
A novel gene edited rat model of cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL).
Monte B, Davis J, Zhu X, Xu F, Majchrzak M, Cabral MJ, Van Nostrand WM, Healey B, Koundal S, Lee H, Robinson JK, Benveniste H, Van Nostrand WE
Cerebral circulation - cognition and behavior 2025;9:100401
Cerebral circulation - cognition and behavior 2025;9:100401
Comprehensive human proteome profiles across a 50-year lifespan reveal aging trajectories and signatures.
Ding Y, Zuo Y, Zhang B, Fan Y, Xu G, Cheng Z, Ma S, Fang S, Tian A, Gao D, Xu X, Wang Q, Jing Y, Jiang M, Xiong M, Li J, Han Z, Sun S, Wang S, He F, Yang J, Qu J, Zhang W, Liu GH
Cell 2025 Oct 2;188(20):5763-5784.e26
Cell 2025 Oct 2;188(20):5763-5784.e26
Role of alpha-1 antitrypsin in Bruch's membrane integrity.
Cheng SY, Giguere D, Silverstein I, Conza A, Seddon JM, Kim S, Iwata T, Mueller C, Punzo C
Scientific reports 2025 Apr 10;15(1):12223
Scientific reports 2025 Apr 10;15(1):12223
Secretome from Magnetically Stimulated Muscle Exhibits Anticancer Potency: Novel Preconditioning Methodology Highlighting HTRA1 Action.
Tai YK, Iversen JN, Chan KKW, Fong CHH, Abdul Razar RB, Ramanan S, Yap LYJ, Yin JN, Toh SJ, Wong CJK, Koh PFA, Huang RYJ, Franco-Obregón A
Cells 2024 Mar 5;13(5)
Cells 2024 Mar 5;13(5)
Instrumental variable and colocalization analyses identify endotrophin and HTRA1 as potential therapeutic targets for coronary artery disease.
Lee PC, Jung IH, Thussu S, Patel V, Wagoner R, Burks KH, Amrute J, Elenbaas JS, Kang CJ, Young EP, Scherer PE, Stitziel NO
iScience 2024 Jul 19;27(7):110104
iScience 2024 Jul 19;27(7):110104
Contribution of Streptococcus pseudopneumoniae and Streptococcus salivarius to vocal fold mucosal integrity and function.
Lungova V, Gowda M, Fernandez JM, Bartley S, Venkatraman A, Rey FE, Thibeault SL
Disease models & mechanisms 2024 Jul 1;17(7)
Disease models & mechanisms 2024 Jul 1;17(7)
HtrA3: a promising prognostic biomarker and therapeutic target for head and neck squamous cell carcinoma.
Chen Y, Yang J, Jin H, Wen W, Xu Y, Zhang X, Wang Y
PeerJ 2023;11:e16237
PeerJ 2023;11:e16237
The identification of hub-methylated differentially expressed genes in osteoarthritis patients is based on epigenomic and transcriptomic data.
Chu ZC, Cong T, Zhao JY, Zhang J, Lou ZY, Gao Y, Tang X
Frontiers in medicine 2023;10:1219830
Frontiers in medicine 2023;10:1219830
Inhibiting HIF-1 signaling alleviates HTRA1-induced RPE senescence in retinal degeneration.
Xu W, Liu X, Han W, Wu K, Zhao M, Mei T, Shang B, Wu J, Luo J, Lai Y, Yang B, Zhuo Y, Lu L, Liu Y, Tian XL, Zhao L
Cell communication and signaling : CCS 2023 Jun 14;21(1):134
Cell communication and signaling : CCS 2023 Jun 14;21(1):134
Long non-coding RNA lincRNA-erythroid prosurvival (EPS) alleviates cerebral ischemia/reperfusion injury by maintaining high-temperature requirement protein A1 (Htra1) stability through recruiting heterogeneous nuclear ribonucleoprotein L (HNRNPL).
Guo H, Guo X, Jiang S
Bioengineered 2022 May;13(5):12248-12260
Bioengineered 2022 May;13(5):12248-12260
Brief exposure to directionally-specific pulsed electromagnetic fields stimulates extracellular vesicle release and is antagonized by streptomycin: A potential regenerative medicine and food industry paradigm.
Wong CJK, Tai YK, Yap JLY, Fong CHH, Loo LSW, Kukumberg M, Fröhlich J, Zhang S, Li JZ, Wang JW, Rufaihah AJ, Franco-Obregón A
Biomaterials 2022 Aug;287:121658
Biomaterials 2022 Aug;287:121658
The "Matrisome" reveals the characterization of skin keloid microenvironment.
Zhang S, Liu B, Wang W, Lv L, Gao D, Chai M, Li M, Wu Z, Zhu Y, Ma J, Leng L
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Apr;35(4):e21237
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Apr;35(4):e21237
Murine osteoclasts secrete serine protease HtrA1 capable of degrading osteoprotegerin in the bone microenvironment.
Ochiai N, Nakachi Y, Yokoo T, Ichihara T, Eriksson T, Yonemoto Y, Kato T, Ogata H, Fujimoto N, Kobayashi Y, Udagawa N, Kaku S, Ueki T, Okazaki Y, Takahashi N, Suda T
Communications biology 2019;2:86
Communications biology 2019;2:86
High-Temperature Requirement A 1 Causes Photoreceptor Cell Death in Zebrafish Disease Models.
Oura Y, Nakamura M, Takigawa T, Fukushima Y, Wakabayashi T, Tsujikawa M, Nishida K
The American journal of pathology 2018 Dec;188(12):2729-2744
The American journal of pathology 2018 Dec;188(12):2729-2744
Emodin Alleviates Sodium Taurocholate-Induced Pancreatic Acinar Cell Injury via MicroRNA-30a-5p-Mediated Inhibition of High-Temperature Requirement A/Transforming Growth Factor Beta 1 Inflammatory Signaling.
Xiang H, Tao X, Xia S, Qu J, Song H, Liu J, Shang D
Frontiers in immunology 2017;8:1488
Frontiers in immunology 2017;8:1488
Proteolytic Degradation and Inflammation Play Critical Roles in Polypoidal Choroidal Vasculopathy.
Kumar S, Nakashizuka H, Jones A, Lambert A, Zhao X, Shen M, Parker M, Wang S, Berriochoa Z, Fnu A, VanBeuge S, Chévez-Barrios P, Tso M, Rainier J, Fu Y
The American journal of pathology 2017 Dec;187(12):2841-2857
The American journal of pathology 2017 Dec;187(12):2841-2857
A frameshift mutation in HTRA1 expands CARASIL syndrome and peripheral small arterial disease to the Chinese population.
Cai B, Zeng J, Lin Y, Lin Y, Lin W, Lin W, Li Z, Wang N
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 2015 Aug;36(8):1387-91
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 2015 Aug;36(8):1387-91
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Supportive validation
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- Proteintech Group (provider)
- Main image
- Experimental details
- The HTRA1 antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human HTRA1. This antibody recognizes human, mouse, rat antigen. The HTRA1 antibody has been validated for the following applications: ELISA, WB analysis.
