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- References [5]
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- Validations
- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 16905-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#16905-1-AP, RRID:AB_2212713
- Product name
- UNC13D/Munc13-4 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated UNC13D/Munc13-4 antibody (Cat. #16905-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IHC, IP, WB, ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Integrative omics indicate FMRP sequesters mRNA from translation and deadenylation in human neuronal cells.
Alternative UNC13D Promoter Encodes a Functional Munc13-4 Isoform Predominantly Expressed in Lymphocytes and Platelets.
A novel Munc13-4/S100A10/annexin A2 complex promotes Weibel-Palade body exocytosis in endothelial cells.
Transcriptional regulation of Munc13-4 expression in cytotoxic lymphocytes is disrupted by an intronic mutation associated with a primary immunodeficiency.
Familial hemophagocytic lymphohistiocytosis type 3 (FHL3) caused by deep intronic mutation and inversion in UNC13D.
Kurosaki T, Mitsutomi S, Hewko A, Akimitsu N, Maquat LE
Molecular cell 2022 Dec 1;82(23):4564-4581.e11
Molecular cell 2022 Dec 1;82(23):4564-4581.e11
Alternative UNC13D Promoter Encodes a Functional Munc13-4 Isoform Predominantly Expressed in Lymphocytes and Platelets.
Galgano D, Soheili T, Voss M, Torralba-Raga L, Tesi B, Cichocki F, Andre I, Rettig J, Cavazzana M, Bryceson Y
Frontiers in immunology 2020;11:1154
Frontiers in immunology 2020;11:1154
A novel Munc13-4/S100A10/annexin A2 complex promotes Weibel-Palade body exocytosis in endothelial cells.
Chehab T, Santos NC, Holthenrich A, Koerdt SN, Disse J, Schuberth C, Nazmi AR, Neeft M, Koch H, Man KNM, Wojcik SM, Martin TFJ, van der Sluijs P, Brose N, Gerke V
Molecular biology of the cell 2017 Jun 15;28(12):1688-1700
Molecular biology of the cell 2017 Jun 15;28(12):1688-1700
Transcriptional regulation of Munc13-4 expression in cytotoxic lymphocytes is disrupted by an intronic mutation associated with a primary immunodeficiency.
Cichocki F, Schlums H, Li H, Stache V, Holmes T, Lenvik TR, Chiang SC, Miller JS, Meeths M, Anderson SK, Bryceson YT
The Journal of experimental medicine 2014 Jun 2;211(6):1079-91
The Journal of experimental medicine 2014 Jun 2;211(6):1079-91
Familial hemophagocytic lymphohistiocytosis type 3 (FHL3) caused by deep intronic mutation and inversion in UNC13D.
Meeths M, Chiang SC, Wood SM, Entesarian M, Schlums H, Bang B, Nordenskjöld E, Björklund C, Jakovljevic G, Jazbec J, Hasle H, Holmqvist BM, Rajic L, Pfeifer S, Rosthøj S, Sabel M, Salmi TT, Stokland T, Winiarski J, Ljunggren HG, Fadeel B, Nordenskjöld M, Henter JI, Bryceson YT
Blood 2011 Nov 24;118(22):5783-93
Blood 2011 Nov 24;118(22):5783-93
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Jurkat cells were subjected to SDS PAGE followed by western blot with 16905-1-AP(UNC13D antibody) at dilution of 1:300
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human spleen using 16905-1-AP(UNC13D antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The UNC13D/Munc13-4 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human UNC13D/Munc13-4. This antibody recognizes human,mouse,rat antigen. The UNC13D/Munc13-4 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
