Tissue expression
Cell line expression
Protein structure
DMBT1
Deleted in malignant brain tumors 1Gp-340, GP340, hensin, muclin, SALSA, vomeroglandin
Loss of sequences from human chromosome 10q has been associated with the progression of human cancers. This gene was originally isolated based on its deletion in a medulloblastoma cell line. This gene is expressed with transcripts of 6.0, 7.5, and 8.0 kb in fetal lung and with one transcript of 8.0 kb in adult lung, although the 7.5 kb transcript has not been characterized. The encoded protein precursor is a glycoprotein containing multiple scavenger receptor cysteine-rich (SRCR) domains separated by SRCR-interspersed domains (SID). Transcript variant 2 (8.0 kb) has been shown to bind surfactant protein D independently of carbohydrate recognition. This indicates that DMBT1 may not be a classical tumor suppressor gene, but rather play a role in the interaction of tumor cells and the immune system. [provided by RefSeq, Mar 2016]
Top validated antibodies |
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Novus Biologicals | NBP2-23576 | 1 references | Monoclonal |
WB
EL
IHC
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Atlas Antibodies | HPA040778 | Polyclonal |
ICC
IHC |
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Invitrogen Antibodies | PA5-115313 | Polyclonal |
WB
ICC
IHC
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Proteintech Group | 27069-1-AP | Polyclonal |
EL
ICC
IHC
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GeneTex | GTX60958 | Monoclonal |
WB
EL
IHC
|
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