14427-1-AP

antibody from Proteintech Group

Targeting: APOA1

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Immunoprecipitation (Data presented on provider website)

Immunohistochemistry (Supportive data in Antibodypedia)

Flow cytometry (Data presented on provider website)

Antibody Data

Product number

14427-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#14427-1-AP, RRID:AB_2056524

Product name

Apolipoprotein AI antibody

Antibody type

Polyclonal

Description

Apolipoprotein AI antibody (Cat. #14427-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: FC, IF, IHC, IP, WB,ELISA.

Reactivity

Human, Mouse

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Apolipoprotein A-1 Accelerated Liver Regeneration Through Regulating Autophagy Via AMPK-ULK1 Pathway.

Wang ZY, Chen RX, Wang JF, Liu SC, Xu X, Zhou T, Chen YAL, Zhang YD, Li XC, Li CX
Cellular and molecular gastroenterology and hepatology 2024;17(4):539-551

---

Apolipoprotein A-1 downregulation promotes basal-like breast cancer cell proliferation and migration associated with DNA methylation.

Wang C, Chen S, Zhang R, Chen M, Yang X, He Y, Shangguan Z, Mao Q, Zhang Z, Ying S
Oncology letters 2024 Jul;28(1):295

---

Lipid-mediated protein corona regulation with increased apolipoprotein A-I recruitment for glioma targeting.

Zhang Y, Xiao W, He S, Xia X, Yang W, Yang Z, Hu H, Wang Y, Wang X, Li H, Huang Y, Gao H
Journal of controlled release : official journal of the Controlled Release Society 2024 Apr;368:42-51

---

Mechanical injury accentuates lipid deposition in ApoE(-/-) mice and advance aortic valve stenosis: A novel modified aortic valve stenosis model.

Wen D, Hu L, Shan J, Zhang H, Hu L, Yuan A, Pu J, Xue S
Frontiers in cardiovascular medicine 2023;10:1119746

---

Inhibiting Phosphatidylcholine Remodeling in Adipose Tissue Increases Insulin Sensitivity.

He M, Li Z, Tung VSK, Pan M, Han X, Evgrafov O, Jiang XC
Diabetes 2023 Nov 1;72(11):1547-1559

---

Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration.

Wu L, Zhou L, An J, Shao X, Zhang H, Wang C, Zhao G, Chen S, Cui X, Zhang X, Yang F, Li X, Zhang X
Journal of translational medicine 2023 Jun 15;21(1):388

---

Single-cell transcriptomics reveals intestinal cell heterogeneity and identifies Ep300 as a potential therapeutic target in mice with acute liver failure.

Yin J, Zhao Z, Huang J, Xiao Y, Rehmutulla M, Zhang B, Zhang Z, Xiang M, Tong Q, Zhang Y
Cell discovery 2023 Jul 25;9(1):77

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Apolipoprotein A-1 protected hepatic ischaemia-reperfusion injury through suppressing macrophage pyroptosis via TLR4-NF-κB pathway.

Chen RX, Jiang WJ, Liu SC, Wang ZY, Wang ZB, Zhou T, Chen YA, Wang JF, Chang J, Wang YR, Zhang YD, Wang XH, Li XC, Li CX
Liver international : official journal of the International Association for the Study of the Liver 2023 Jan;43(1):234-248

---

Effect of Total Sphingomyelin Synthase Activity on Low Density Lipoprotein Catabolism in Mice.

Li Z, He M, Chen G, Worgall TS, Jiang XC
bioRxiv : the preprint server for biology 2023 Feb 7;

---

Skeletal muscle releases extracellular vesicles with distinct protein and microRNA signatures that function in the muscle microenvironment.

Watanabe S, Sudo Y, Makino T, Kimura S, Tomita K, Noguchi M, Sakurai H, Shimizu M, Takahashi Y, Sato R, Yamauchi Y
PNAS nexus 2022 Sep;1(4):pgac173

---

Exercise promotes angiogenesis by enhancing endothelial cell fatty acid utilization via liver-derived extracellular vesicle miR-122-5p.

Lou J, Wu J, Feng M, Dang X, Wu G, Yang H, Wang Y, Li J, Zhao Y, Shi C, Liu J, Zhao L, Zhang X, Gao F
Journal of sport and health science 2022 Jul;11(4):495-508

---

Lubiprostone significantly represses fatty liver diseases via induction of mucin and HDL release in mice.

Kim MY, Lee SJ, Randolph G, Han YH
Life sciences 2022 Dec 15;311(Pt A):121176

---

Incidence and Characterization of Concealed Cardiac Amyloidosis Among Unselected Elderly Patients Undergoing Post-mortem Examination.

Porcari A, Bussani R, Merlo M, Varrà GG, Pagura L, Rozze D, Sinagra G
Frontiers in cardiovascular medicine 2021;8:749523

---

Exosome-mediated delivery of inflammation-responsive Il-10 mRNA for controlled atherosclerosis treatment.

Bu T, Li Z, Hou Y, Sun W, Zhang R, Zhao L, Wei M, Yang G, Yuan L
Theranostics 2021;11(20):9988-10000

---

Tear dynamics testing and quantitative proteomics analysis in patients with chronic renal failure.

Zong RR, Zhu FF, Han W, Wang YX, Wang GL, Wang YZ, Mao YB, Guan TJ, Liu ZG, Xue YH, Li C
Journal of proteomics 2021 Sep 30;248:104351

---

Vitamin A and retinoic acid accelerate the attenuation of intestinal adaptability upon feeding induced by high-fat diet in mice.

Hong W, Xu D, Song X, Niu B, Zhuang Z, Lu Y, Lei X, Ma R, Lu C, Sun N, Mao Y, Li X
The Journal of nutritional biochemistry 2021 Nov;97:108803

---

Upregulation of ENDOU in cytotrophoblasts from placenta complicated with preeclampsia and fetal growth restriction.

Nomoto M, Kotani T, Miki R, Ushida T, Imai K, Iitani Y, Tano S, Wang J, Moriyama Y, Kobayashi T, Mimura N, Iriyama T, Kikkawa F, Kajiyama H
Journal of clinical biochemistry and nutrition 2021 Nov;69(3):280-285

---

TRIM15 promotes the invasion and metastasis of pancreatic cancer cells by mediating APOA1 ubiquitination and degradation.

Sun Y, Ren D, Yang C, Yang W, Zhao J, Zhou Y, Jin X, Wu H
Biochimica et biophysica acta. Molecular basis of disease 2021 Nov 1;1867(11):166213

---

Quantitative proteomics of plasma and liver reveals the mechanism of turmeric in preventing hyperlipidemia in mice.

Wang M, Wang R, Li L, Yan Y, Jia S, Jiang H, Du Z
Food & function 2021 Nov 1;12(21):10484-10499

---

Association of urinary ketamine and APOA1 levels with bladder dysfunction in ketamine abusers revealed via proteomics and targeted metabolite analyses.

Liu JC, Chen YT, Hsieh YJ, Wu CC, Huang MC, Hsu YC, Wu CT, Chen CK, Dash S, Yu JS
Scientific reports 2021 May 5;11(1):9583

---

Proteomic Analysis of Plasma sEVs Reveals That TNFAIP8 Is a New Biomarker of Cell Proliferation in Diabetic Retinopathy.

Xiao J, Zhang H, Yang F, Xiao M, Zhou L, Yu R, Shao X, Ea V, Su L, Zhang X, Li X
Journal of proteome research 2021 Mar 5;20(3):1770-1782

---

Astrocytic ApoE reprograms neuronal cholesterol metabolism and histone-acetylation-mediated memory.

Li X, Zhang J, Li D, He C, He K, Xue T, Wan L, Zhang C, Liu Q
Neuron 2021 Mar 17;109(6):957-970.e8

---

miR-33a-5p in small extracellular vesicles as non-invasive biomarker for oxaliplatin sensitivity in human colorectal cancer cells.

Tanaka S, Hosokawa M, Miyamoto T, Nakagawa A, Haruna M, Ueda K, Iwakawa S, Ogawara KI
Biochemistry and biophysics reports 2021 Jul;26:100996

---

Enterically derived high-density lipoprotein restrains liver injury through the portal vein.

Han YH, Onufer EJ, Huang LH, Sprung RW, Davidson WS, Czepielewski RS, Wohltmann M, Sorci-Thomas MG, Warner BW, Randolph GJ
Science (New York, N.Y.) 2021 Jul 23;373(6553)

---

Binding of Macrophage Receptor MARCO, LDL, and LDLR to Disease-Associated Crystalline Structures.

Alberts A, Klingberg A, Hoffmeister L, Wessig AK, Brand K, Pich A, Neumann K
Frontiers in immunology 2020;11:596103

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A novel apoA-I mimetic peptide suppresses atherosclerosis by promoting physiological HDL function in apoE(-/-) mice.

Gou S, Wang L, Zhong C, Chen X, Ouyang X, Li B, Bao G, Liu H, Zhang Y, Ni J
British journal of pharmacology 2020 Oct;177(20):4627-4644

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Bromelain Confers Protection against the Non-Alcoholic Fatty Liver Disease in Male C57bl/6 Mice.

Hu PA, Chen CH, Guo BC, Kou YR, Lee TS
Nutrients 2020 May 18;12(5)

---

Serum proteomic predicts effectiveness and reveals potential biomarkers for complications in liver transplant patients.

Wang W, Wang B, Liu C, Yan J, Xiong X, Wang X, Yang J, Guo B, Huang C
Aging 2020 Jun 12;12(12):12119-12141

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Disruption in the balance between apolipoprotein A-I and mast cell chymase in chronic hypersensitivity pneumonitis.

Inoue Y, Okamoto T, Honda T, Nukui Y, Akashi T, Takemura T, Tozuka M, Miyazaki Y
Immunity, inflammation and disease 2020 Dec;8(4):659-671

---

Apolipoprotein A-I improves hepatic autophagy through the AMPK pathway.

Rao X, Wang Y
Biochimie 2019 Oct;165:210-218

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Proteomic analysis of mouse ovaries during the prepubertal stages.

Xiong J, Wu M, Zhang Q, Zhang C, Xiong G, Ma L, Lu Z, Wang S
Experimental cell research 2019 Apr 15;377(1-2):36-46

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Effects of sepsis on the metabolism of sphingomyelin and cholesterol in mice with liver dysfunction.

Li J, Xia K, Xiong M, Wang X, Yan N
Experimental and therapeutic medicine 2017 Dec;14(6):5635-5640

---

A new panel of pancreatic cancer biomarkers discovered using a mass spectrometry-based pipeline.

Liu X, Zheng W, Wang W, Shen H, Liu L, Lou W, Wang X, Yang P
British journal of cancer 2017 Dec 5;117(12):1846-1854

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Proteomics approaches for identification of tumor relevant protein targets in pulmonary squamous cell carcinoma by 2D-DIGE-MS.

Lihong H, Linlin G, Yiping G, Yang S, Xiaoyu Q, Zhuzhu G, Xiaohan Y, Xin Z, Liyan X, Shujuan S
PloS one 2014;9(4):e95121

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Trophoblast apoptosis from pregnancies complicated by fetal growth restriction is associated with enhanced p53 expression.

Levy R, Smith SD, Yusuf K, Huettner PC, Kraus FT, Sadovsky Y, Nelson DM
American journal of obstetrics and gynecology 2002 May;186(5):1056-61

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

human blood tissue were subjected to SDS PAGE followed by western blot with 14427-1-AP(APOA1 antibody) at dilution of 1:1000

Sample type

tissue

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human liver cancer using 14427-1-AP(APOA1 antibody) at dilution of 1:100 (under 10x lens)

Sample type

tissue

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

The Apolipoprotein AI antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Apolipoprotein AI. This antibody recognizes human, mouse antigen. The Apolipoprotein AI antibody has been validated for the following applications: ELISA, WB, IHC analysis.

Appendix

14427-1-AP.pdf

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