17082-1-AP

antibody from Proteintech Group

Targeting: RPL24 L24

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunocytochemistry (Supportive data in Antibodypedia)

Immunoprecipitation (Data presented on provider website)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

17082-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#17082-1-AP, RRID:AB_2181728

Product name

RPL24 antibody

Antibody type

Polyclonal

Description

KD/KO validated RPL24 antibody (Cat. #17082-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, IP, WB,ELISA.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Neurons with granulovacuolar degeneration bodies are resilient to tau-induced protein synthesis impairment.

Smits JFM, Ligthart TW, Jorge-Oliva M, Middelhoff S, Schipper F, Pita-Illobre D, Li KW, Scheper W
Science advances 2026 Mar 6;12(10):eaea8940

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Maintenance of neuronal TDP-43 expression requires axonal lysosome transport.

Ryan VH, Lawton S, Reyes JF, Hawrot J, Frankenfield AM, Seddighi S, Ramos DM, Epstein J, Faghri F, Johnson NL, Zou J, Kampmann M, Replogle J, Qi YA, Yuan H, Johnson K, Maric D, Hao L, Nalls MA, Ward ME
eLife 2025 Sep 19;14

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Integrative multiomic analysis links TDP-43-driven splicing defects to cascading proteomic disruption of ALS/FTD pathways.

Kozareva V, Liu Z, Blake K, Qi YA, Rollinson S, Seddighi S, Alsaidi M, Tsitkov S, Prudencio M, Petrucelli L, Dickson DW, Brown AL, Fratta P, Kim HJ, Taylor JP, Ward ME, Fraenkel E, Kargbo-Hill SE
bioRxiv : the preprint server for biology 2025 Nov 1;

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Pre-symptomatic Parkinson's disease blood test quantifying repetitive sequence motifs in transfer RNA fragments.

Madrer N, Vaknine-Treidel S, Zorbaz T, Tzur Y, Bennett ER, Drori P, Suissa N, Greenberg DS, Lerner E, Soreq E, Paldor I, Soreq H
Nature aging 2025 May;5(5):868-882

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Puromycin Proximity Ligation Assay (Puro-PLA) to Assess Local Translation in Axons From Human Neurons.

De Pace R, Bonifacino JS, Ghosh S
Bio-protocol 2025 Mar 5;15(5):e5224

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Altered mRNA transport and local translation in i3Neurons with RNA-binding protein knockdown.

Dargan R, Mikheenko A, Johnson NL, Packer BE, Li Z, Craig EJ, Como CN, Sarbanes SL, Bereda C, Hao Y, Mehta PR, Keuss M, Nalls MA, Qi YA, Weller CA, Fratta P, Ryan VH
Nucleic acids research 2025 Jul 19;53(14)

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N(6)-methyladenosine in 28S rRNA promotes oncogenic mRNA translation and tyrosine catabolism.

Chen B, Li L, Huang Y, Ma J, Ji F, Chen Y, Wu L, Peng H
Cell reports 2025 Jan 28;44(1):115139

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Altered mRNA transport and local translation in iNeurons with RNA binding protein knockdown.

Dargan R, Mikheenko A, Johnson NL, Packer B, Li Z, Craig EJ, Sarbanes SL, Bereda C, Mehta PR, Keuss M, Nalls MA, Qi YA, Weller CA, Fratta P, Ryan VH
bioRxiv : the preprint server for biology 2024 Sep 27;

---

ADAR3 modulates neuronal differentiation and regulates mRNA stability and translation.

Karlström V, Sagredo EA, Planells J, Welinder C, Jungfleisch J, Barrera-Conde A, Engfors L, Daniel C, Gebauer F, Visa N, Öhman M
Nucleic acids research 2024 Oct 28;52(19):12021-12038

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Ribosomal Dysregulation in Metastatic Laryngeal Squamous Cell Carcinoma: Proteomic Insights and CX-5461's Therapeutic Promise.

Gao M, Liu T, Hu K, Chen S, Wang S, Gan D, Li Z, Lin X
Toxics 2024 May 13;12(5)

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Widespread stable noncanonical peptides identified by integrated analyses of ribosome profiling and ORF features.

Yang H, Li Q, Stroup EK, Wang S, Ji Z
Nature communications 2024 Mar 2;15(1):1932

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Messenger RNA transport on lysosomal vesicles maintains axonal mitochondrial homeostasis and prevents axonal degeneration.

De Pace R, Ghosh S, Ryan VH, Sohn M, Jarnik M, Rezvan Sangsari P, Morgan NY, Dale RK, Ward ME, Bonifacino JS
Nature neuroscience 2024 Jun;27(6):1087-1102

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Ribosomal protein L24 mediates mammalian microRNA processing in an evolutionarily conserved manner.

Tzur Y, Dubnov S, Madrer N, Bar A, Nadorp B, Mishra N, Heppenstall P, Bennett ER, Greenberg DS, Winek K, Soreq H
Cellular and molecular life sciences : CMLS 2024 Jan 23;81(1):55

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Axonal endoplasmic reticulum tubules control local translation via P180/RRBP1-mediated ribosome interactions.

Koppers M, Özkan N, Nguyen HH, Jurriens D, McCaughey J, Nguyen DTM, Li CH, Stucchi R, Altelaar M, MacGillavry HD, Kapitein LC, Hoogenraad CC, Farías GG
Developmental cell 2024 Aug 19;59(16):2053-2068.e9

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RPL24 as a potential prognostic biomarker for cervical cancer treated by Cisplatin and concurrent chemoradiotherapy.

Ming C, Bai X, Zhao L, Yu D, Wang X, Wu Y
Frontiers in oncology 2023;13:1131803

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The proteome and transcriptome of stress granules and P bodies during human T lymphocyte activation.

Curdy N, Lanvin O, Cerapio JP, Pont F, Tosolini M, Sarot E, Valle C, Saint-Laurent N, Lhuillier E, Laurent C, Fournié JJ, Franchini DM
Cell reports 2023 Mar 28;42(3):112211

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N(6)-methyladenosine modification in 18S rRNA promotes tumorigenesis and chemoresistance via HSF4b/HSP90B1/mutant p53 axis.

Chen B, Huang Y, He S, Yu P, Wu L, Peng H
Cell chemical biology 2023 Feb 16;30(2):144-158.e10

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ZEA and DON inhibited inflammation after L. monocytogenes infection and induced ribosomal hyperfunction.

Cai G, Zhong F, Cao Q, Bai Y, Zou H, Gu J, Yuan Y, Zhu G, Liu Z, Bian J
Ecotoxicology and environmental safety 2022 May 1;236:113470

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N(6)-methyladenosine (m(6)A) in 18S rRNA promotes fatty acid metabolism and oncogenic transformation.

Peng H, Chen B, Wei W, Guo S, Han H, Yang C, Ma J, Wang L, Peng S, Kuang M, Lin S
Nature metabolism 2022 Aug;4(8):1041-1054

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Proteomic Landscape of Exosomes Reveals the Functional Contributions of CD151 in Triple-Negative Breast Cancer.

Li S, Li X, Yang S, Pi H, Li Z, Yao P, Zhang Q, Wang Q, Shen P, Li X, Ji J
Molecular & cellular proteomics : MCP 2021;20:100121

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HectD1 controls hematopoietic stem cell regeneration by coordinating ribosome assembly and protein synthesis.

Lv K, Gong C, Antony C, Han X, Ren JG, Donaghy R, Cheng Y, Pellegrino S, Warren AJ, Paralkar VR, Tong W
Cell stem cell 2021 Jul 1;28(7):1275-1290.e9

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Local translation in nuclear condensate amyloid bodies.

Theodoridis PR, Bokros M, Marijan D, Balukoff NC, Wang D, Kirk CC, Budine TD, Goldsmith HD, Wang M, Audas TE, Lee S
Proceedings of the National Academy of Sciences of the United States of America 2021 Feb 16;118(7)

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Ribosome ADP-ribosylation inhibits translation and maintains proteostasis in cancers.

Challa S, Khulpateea BR, Nandu T, Camacho CV, Ryu KW, Chen H, Peng Y, Lea JS, Kraus WL
Cell 2021 Aug 19;184(17):4531-4546.e26

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Late Endosomes Act as mRNA Translation Platforms and Sustain Mitochondria in Axons.

Cioni JM, Lin JQ, Holtermann AV, Koppers M, Jakobs MAH, Azizi A, Turner-Bridger B, Shigeoka T, Franze K, Harris WA, Holt CE
Cell 2019 Jan 10;176(1-2):56-72.e15

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Rapid Cue-Specific Remodeling of the Nascent Axonal Proteome.

Cagnetta R, Frese CK, Shigeoka T, Krijgsveld J, Holt CE
Neuron 2018 Jul 11;99(1):29-46.e4

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Jurkat cells were subjected to SDS PAGE followed by western blot with 17082-1-AP(RPL24 antibody) at dilution of 1:500

Sample type

cell line

Immunocytochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunofluorescent analysis of Hela cells, using RPL24 antibody 17082-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).

Sample type

cell line

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human placenta using 17082-1-AP(RPL24 antibody) at dilution of 1:100 (under 10x lens)

Sample type

tissue

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human placenta using 17082-1-AP(RPL24 antibody) at dilution of 1:100 (under 40x lens)

Sample type

tissue