Explore
Validate
Learn
Western blot
ImmunohistochemistryAntibody data
- Antibody Data
- Antigen structure
- References [3]
- Comments [0]
- Validations
- Immunohistochemistry [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- HPA057002 - Provider product page
- Provider
- Atlas Antibodies
- Proper citation
- Atlas Antibodies Cat#HPA057002, RRID:AB_2683308
- Product name
- Anti-AKR1D1
- Antibody type
- Polyclonal
- Description
- Polyclonal Antibody against Human AKR1D1, Gene description: aldo-keto reductase family 1, member D1, Alternative Gene Names: SRD5B1, Validated applications: IHC, WB, Uniprot ID: P51857, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 µl
- Concentration
- 0.05 mg/ml
- Storage
- Store at +4°C for short term storage. Long time storage is recommended at -20°C.
- Handling
- The antibody solution should be gently mixed before use.
Submitted references Differential activity and expression of human 5β-reductase (AKR1D1) splice variants.
Glucocorticoids regulate AKR1D1 activity in human liver in vitro and in vivo.
AKR1D1 is a novel regulator of metabolic phenotype in human hepatocytes and is dysregulated in non-alcoholic fatty liver disease.
Appanna N, Gibson H, Gangitano E, Dempster NJ, Morris K, George S, Arvaniti A, Gathercole LL, Keevil B, Penning TM, Storbeck KH, Tomlinson JW, Nikolaou N
Journal of molecular endocrinology 2021 Mar;66(3):181-194
Journal of molecular endocrinology 2021 Mar;66(3):181-194
Glucocorticoids regulate AKR1D1 activity in human liver in vitro and in vivo.
Nikolaou N, Arvaniti A, Appanna N, Sharp A, Hughes BA, Digweed D, Whitaker MJ, Ross R, Arlt W, Penning TM, Morris K, George S, Keevil BG, Hodson L, Gathercole LL, Tomlinson JW
The Journal of endocrinology 2020 May;245(2):207-218
The Journal of endocrinology 2020 May;245(2):207-218
AKR1D1 is a novel regulator of metabolic phenotype in human hepatocytes and is dysregulated in non-alcoholic fatty liver disease.
Nikolaou N, Gathercole LL, Marchand L, Althari S, Dempster NJ, Green CJ, van de Bunt M, McNeil C, Arvaniti A, Hughes BA, Sgromo B, Gillies RS, Marschall HU, Penning TM, Ryan J, Arlt W, Hodson L, Tomlinson JW
Metabolism: clinical and experimental 2019 Oct;99:67-80
Metabolism: clinical and experimental 2019 Oct;99:67-80
No comments: Submit comment
Supportive validation
- Submitted by
- Atlas Antibodies (provider)
- Enhanced method
- Orthogonal validation
- Main image
- Experimental details
- Immunohistochemistry analysis in human liver and kidney tissues using HPA057002 antibody. Corresponding AKR1D1 RNA-seq data are presented for the same tissues.
- Sample type
- Human
- Protocol
- Protocol
