14208-1-AP

antibody from Proteintech Group

Targeting: TRIM24 hTIF1, RNF82, TIF1, Tif1a

Provider product page for 14208-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [40]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [2]

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Product number: 14208-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#14208-1-AP, RRID:AB_2256646
Product name: TRIM24 antibody
Antibody type: Polyclonal
Description: KD/KO validated TRIM24 antibody (Cat. #14208-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

TRIM24 protein structure - 14208-1-AP shown in red.

Submitted references Retinoblastoma-associated protein is important for TRIM24-mediated activation of the mTOR signaling pathway through DUSP2 action in prostate cancer.

Ren D, Li W, Zeng R, Liu X, Liang H, Xiong W, Yang C, Jin X
Cell death and differentiation 2024 May;31(5):592-604

Inhibition of ATM-directed antiviral responses by HIV-1 Vif.

Wong HT, Luperchio AM, Riley S, Salamango DJ
PLoS pathogens 2023 Sep;19(9):e1011634

Upstream Stimulatory Factors Regulate HIV-1 Latency and Are Required for Robust T Cell Activation.

Horvath RM, Sadowski I
Viruses 2023 Jun 28;15(7)

Readout of histone methylation by Trim24 locally restricts chromatin opening by p53.

Isbel L, Iskar M, Durdu S, Weiss J, Grand RS, Hietter-Pfeiffer E, Kozicka Z, Michael AK, Burger L, Thomä NH, Schübeler D
Nature structural & molecular biology 2023 Jul;30(7):948-957

Genome-wide CRISPR-Cas9 screen analyzed by SLIDER identifies network of repressor complexes that regulate TRIM24.

Patel LR, Stratton SA, McLaughlin M, Krause P, Allton K, Rivas AL, Barbosa D, Hart T, Barton MC
iScience 2023 Jul 21;26(7):107126

TRIM24 controls induction of latent HIV-1 by stimulating transcriptional elongation.

Horvath RM, Dahabieh M, Malcolm T, Sadowski I
Communications biology 2023 Jan 23;6(1):86

p53 engages the cGAS/STING cytosolic DNA sensing pathway for tumor suppression.

Ghosh M, Saha S, Li J, Montrose DC, Martinez LA
Molecular cell 2023 Jan 19;83(2):266-280.e6

Inhibition of the TRIM24 bromodomain reactivates latent HIV-1.

Horvath RM, Brumme ZL, Sadowski I
Scientific reports 2023 Jan 11;13(1):556

TRIM24 is critical for the cellular response to DNA double-strand breaks through regulating the recruitment of MRN complex.

Wang Y, Yao Y, Wei Q, Long S, Chen Y, Xie J, Tan R, Jiang W, Zhang Q, Wu D, Xiao S, Wan F, Fu K
Oncogene 2023 Feb;42(8):586-600

Targeting TRIM24 promotes neuroblastoma differentiation and decreases tumorigenicity via LSD1/CoREST complex.

Shi Q, Yu B, Zhang Y, Yang Y, Xu C, Zhang M, Chen G, Luo F, Sun B, Yang R, Li Y, Feng H
Cellular oncology (Dordrecht, Netherlands) 2023 Dec;46(6):1763-1775

USP7 inhibits the progression of nasopharyngeal carcinoma via promoting SPLUNC1-mediated M1 macrophage polarization through TRIM24.

Liu H, Tang L, Gong S, Xiao T, Yang H, Gu W, Wang H, Chen P
Cell death & disease 2023 Dec 21;14(12):852

miR-339-3p inhibits cell growth and epithelial-mesenchymal transition in nasopharyngeal carcinoma by modulating the KAT6A/TRIM24 axis.

Gao P, Zhao K, Lu W, Wang L, Zhang P
International journal of clinical oncology 2022 Nov;27(11):1684-1697

LncRNA PVT1 promotes tumorigenesis of glioblastoma by recruiting COPS5 to deubiquitinate and stabilize TRIM24.

Lv T, Jin Y, Miao Y, Xu T, Jia F, Feng H, Zhang X
Molecular therapy. Nucleic acids 2022 Mar 8;27:109-121

TRIM24 Expression as an Independent Biomarker for Prognosis and Tumor Recurrence in HNSCC.

Klapper L, Idel C, Kuppler P, Jagomast T, von Bernuth A, Bruchhage KL, Rades D, Offermann A, Kirfel J, Perner S, Ribbat-Idel J
Journal of personalized medicine 2022 Jun 17;12(6)

Smoking-associated upregulation of CBX3 suppresses ARHGAP24 expression to activate Rac1 signaling and promote tumor progression in lung adenocarcinoma.

Jin X, Zhang B, Zhang H, Yu H
Oncogene 2022 Jan;41(4):538-549

Mammary-specific expression of Trim24 establishes a mouse model of human metaplastic breast cancer.

Shah VV, Duncan AD, Jiang S, Stratton SA, Allton KL, Yam C, Jain A, Krause PM, Lu Y, Cai S, Tu Y, Zhou X, Zhang X, Jiang Y, Carroll CL, Kang Z, Liu B, Shen J, Gagea M, Manu SM, Huo L, Gilcrease M, Powell RT, Guo L, Stephan C, Davies PJ, Parker-Thornburg J, Lozano G, Behringer RR, Piwnica-Worms H, Chang JT, Moulder SL, Barton MC
Nature communications 2021 Sep 10;12(1):5389

Identification of proximal SUMO-dependent interactors using SUMO-ID.

Barroso-Gomila O, Trulsson F, Muratore V, Canosa I, Merino-Cacho L, Cortazar AR, Pérez C, Azkargorta M, Iloro I, Carracedo A, Aransay AM, Elortza F, Mayor U, Vertegaal ACO, Barrio R, Sutherland JD
Nature communications 2021 Nov 18;12(1):6671

The Sumo proteome of proliferating and neuronal-differentiating cells reveals Utf1 among key Sumo targets involved in neurogenesis.

Correa-Vázquez JF, Juárez-Vicente F, García-Gutiérrez P, Barysch SV, Melchior F, García-Domínguez M
Cell death & disease 2021 Mar 22;12(4):305

E3 ubiquitin ligase TRIM24 deficiency promotes NLRP3/caspase-1/IL-1β-mediated pyroptosis in endometriosis.

Hang Y, Tan L, Chen Q, Liu Q, Jin Y
Cell biology international 2021 Jul;45(7):1561-1570

TRIP12 promotes small-molecule-induced degradation through K29/K48-branched ubiquitin chains.

Kaiho-Soma A, Akizuki Y, Igarashi K, Endo A, Shoda T, Kawase Y, Demizu Y, Naito M, Saeki Y, Tanaka K, Ohtake F
Molecular cell 2021 Apr 1;81(7):1411-1424.e7

BMP8A promotes survival and drug resistance via Nrf2/TRIM24 signaling pathway in clear cell renal cell carcinoma.

Yu YP, Cai LC, Wang XY, Cheng SY, Zhang DM, Jian WG, Wang TD, Yang JK, Yang KB, Zhang C
Cancer science 2020 May;111(5):1555-1566

TRIM24 facilitates antiviral immunity through mediating K63-linked TRAF3 ubiquitination.

Zhu Q, Yu T, Gan S, Wang Y, Pei Y, Zhao Q, Pei S, Hao S, Yuan J, Xu J, Hou F, Wu X, Peng C, Wu P, Qin J, Xiao Y
The Journal of experimental medicine 2020 Jul 6;217(7)

TRIM24 as an independent prognostic biomarker for prostate cancer.

Offermann A, Roth D, Hupe MC, Hohensteiner S, Becker F, Joerg V, Carlsson J, Kuempers C, Ribbat-Idel J, Tharun L, Sailer V, Kirfel J, Svensson M, Andren O, Lubczyk V, Kuefer R, Merseburger AS, Perner S
Urologic oncology 2019 Sep;37(9):576.e1-576.e10

Modulation of M2 macrophage polarization by the crosstalk between Stat6 and Trim24.

Yu T, Gan S, Zhu Q, Dai D, Li N, Wang H, Chen X, Hou D, Wang Y, Pan Q, Xu J, Zhang X, Liu J, Pei S, Peng C, Wu P, Romano S, Mao C, Huang M, Zhu X, Shen K, Qin J, Xiao Y
Nature communications 2019 Sep 25;10(1):4353

Overexpression of TRIM24 Stimulates Proliferation and Glucose Metabolism of Head and Neck Squamous Cell Carcinoma.

Wang H, Xue W, Jiang X
BioMed research international 2018;2018:6142843

Tripartite Motif Containing 24 Acts as a Novel Coactivator of the Constitutive Active/Androstane Receptor.

Kanno Y, Kure Y, Kobayashi S, Mizuno M, Tsuchiya Y, Yamashita N, Nemoto K, Inouye Y
Drug metabolism and disposition: the biological fate of chemicals 2018 Jan;46(1):46-52

Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands.

Gechijian LN, Buckley DL, Lawlor MA, Reyes JM, Paulk J, Ott CJ, Winter GE, Erb MA, Scott TG, Xu M, Seo HS, Dhe-Paganon S, Kwiatkowski NP, Perry JA, Qi J, Gray NS, Bradner JE
Nature chemical biology 2018 Apr;14(4):405-412

Overexpression of TRIM24 is correlated with the progression of human cervical cancer.

Lin L, Zhao W, Sun B, Wang X, Liu Q
American journal of translational research 2017;9(2):620-628

Histone Acetyltransferase KAT6A Upregulates PI3K/AKT Signaling through TRIM24 Binding.

Lv D, Jia F, Hou Y, Sang Y, Alvarez AA, Zhang W, Gao WQ, Hu B, Cheng SY, Ge J, Li Y, Feng H
Cancer research 2017 Nov 15;77(22):6190-6201

TRIM24 is an oncogenic transcriptional co-activator of STAT3 in glioblastoma.

Lv D, Li Y, Zhang W, Alvarez AA, Song L, Tang J, Gao WQ, Hu B, Cheng SY, Feng H
Nature communications 2017 Nov 13;8(1):1454

TRIM24 protein promotes and TRIM32 protein inhibits cardiomyocyte hypertrophy via regulation of dysbindin protein levels.

Borlepawar A, Rangrez AY, Bernt A, Christen L, Sossalla S, Frank D, Frey N
The Journal of biological chemistry 2017 Jun 16;292(24):10180-10196

Clinical significance and prognostic value of TRIM24 expression in esophageal squamous cell carcinoma.

Chi J, Yang Q, Xie XF, Yang XZ, Zhang MY, Wang HY, Xu GL
Aging 2016 Sep 28;8(9):2204-2221

Histone H3 lysine 23 acetylation is associated with oncogene TRIM24 expression and a poor prognosis in breast cancer.

Ma L, Yuan L, An J, Barton MC, Zhang Q, Liu Z
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Nov;37(11):14803-14812

Development of novel cellular histone-binding and chromatin-displacement assays for bromodomain drug discovery.

Zhan Y, Kost-Alimova M, Shi X, Leo E, Bardenhagen JP, Shepard HE, Appikonda S, Vangamudi B, Zhao S, Tieu TN, Jiang S, Heffernan TP, Marszalek JR, Toniatti C, Draetta G, Tyler J, Barton M, Jones P, Palmer WS, Geck Do MK, Andersen JN
Epigenetics & chromatin 2015;8:37

Clinical significance and biological roles of TRIM24 in human bladder carcinoma.

Xue D, Zhang X, Zhang X, Liu J, Li N, Liu C, Liu Y, Wang P
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2015 Sep;36(9):6849-55

TRIM24 is upregulated in human gastric cancer and promotes gastric cancer cell growth and chemoresistance.

Miao ZF, Wang ZN, Zhao TT, Xu YY, Wu JH, Liu XY, Xu H, You Y, Xu HM
Virchows Archiv : an international journal of pathology 2015 May;466(5):525-32

TRIM24 links glucose metabolism with transformation of human mammary epithelial cells.

Pathiraja TN, Thakkar KN, Jiang S, Stratton S, Liu Z, Gagea M, Shi X, Shah PK, Phan L, Lee MH, Andersen J, Stampfer M, Barton MC
Oncogene 2015 May 28;34(22):2836-45

TRIM24 overexpression is common in locally advanced head and neck squamous cell carcinoma and correlates with aggressive malignant phenotypes.

Cui Z, Cao W, Li J, Song X, Mao L, Chen W
PloS one 2013;8(5):e63887

Overexpression of TRIM24 correlates with tumor progression in non-small cell lung cancer.

Li H, Sun L, Tang Z, Fu L, Xu Y, Li Z, Luo W, Qiu X, Wang E
PloS one 2012;7(5):e37657

TRIM24 links a non-canonical histone signature to breast cancer.

Tsai WW, Wang Z, Yiu TT, Akdemir KC, Xia W, Winter S, Tsai CY, Shi X, Schwarzer D, Plunkett W, Aronow B, Gozani O, Fischle W, Hung MC, Patel DJ, Barton MC
Nature 2010 Dec 16;468(7326):927-32

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HeLa cells were subjected to SDS PAGE followed by western blot with 14208-1-AP(TRIM24 antibody) at dilution of 1:500
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human prostate cancer using 14208-1-AP(TRIM24 antibody) at dilution of 1:100 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The TRIM24 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human TRIM24. This antibody recognizes human,mouse,rat antigen. The TRIM24 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 14208-1-AP.pdf

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