11052-1-AP

antibody from Proteintech Group

Targeting: AMD1 SAMDC

Provider product page for 11052-1-AP

Western blot

ELISA

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [21]
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Validations
Immunohistochemistry [1]

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Product number: 11052-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#11052-1-AP, RRID:AB_2226430
Product name: AMD1 antibody
Antibody type: Polyclonal
Description: KD/KO validated AMD1 antibody (Cat. #11052-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IHC, WB, ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

AMD1 protein structure - 11052-1-AP shown in red.

Submitted references Polyamine-dependent metabolic shielding regulates alternative splicing.

Zabala-Letona A, Pujana-Vaquerizo M, Martinez-Laosa B, Ponce-Rodriguez M, Garcia-Longarte S, Mendizabal I, Gimeno A, Rogalska M, Tan J, Cabrera D, van Liempd S, Ximenez-Embun P, Espinosa S, Fagoaga-Eugui M, Peccati F, Zakrzewski M, Astobiza I, Arana-Castañares M, Cherkaoui S, Sendino M, Martín-Barros I, Ercilla A, Bozal-Basterra L, Carlevaris O, Arruabarrena-Aristorena A, Pérez-Andrés E, Santamaría-Zamorano T, Ferrer-Bonsoms JA, Carazo F, Cieśla M, Lobato C, Seoane J, Martín-Martín N, Barrio R, Sutherland JD, Aransay AM, Falcón-Pérez JM, Martínez-Pastor B, Rubio A, Blanco FJ, Hogarty MD, Morscher RJ, Berra E, Serwa RA, Jiménez-Barbero J, Jiménez-Osés G, Efeyan A, Finley L, Lizcano JM, Muñoz J, Valcarcel J, Carracedo A
Nature 2026 Mar;651(8106):819-828

Androgen Receptor Drives Polyamine Synthesis, Creating a Vulnerability for Prostate Cancer.

Kumar R, Jonnatan S, Sanin DE, Vakkala V, Kadam A, Kumar S, Rosen DM, Dalrymple SL, Zhao L, Foley JR, Holbert CE, Nwafor A, Kittane S, Penner E, Apostolova P, Warner S, Dang CV, Toska E, Thompson EA, Isaacs JT, De Marzo AM, Brennen WN, Pearce EL, Stewart TM, Casero RA Jr, Denmeade SR, Sena LA
Cancer research 2026 Mar 2;86(5):1148-1165

Integrative metabolomic and single-cell transcriptomic analysis of recurrent condyloma acuminatum in humans.

Wei Y, Xu Y, Feng C, Chen S, Chen J, Wang J, Pan J, Song Y, Hua C, Cai M, Cheng H, Zhu J
Scientific reports 2026 Feb 4;16(1)

AMD1, a cardiotoxicity target for Maduramicin.

Xie ZF, Liu HM, Zhao JF, Gao Y, Zhao YL, Zheng JY, Pei XW, Zhang N, Tian G
BMC pharmacology & toxicology 2025 Mar 11;26(1):55

Polyamine depletion limits progression of acute leukaemia.

Gao W, Karsa M, Xiao L, Spurling D, Karsa A, Ronca E, Bongers A, Guo X, Mayoh C, Azfar M, Verhelst SHL, Tanaka K, Cheung LC, Kotecha RS, Lock RB, Burns MR, Vangheluwe P, Norris MD, Haber M, Somers K
International journal of cancer 2025 Jun 15;156(12):2360-2376

Polyamine and EIF5A hypusination downstream of c-Myc confers targeted therapy resistance in BRAF mutant melanoma.

Park BS, Jeon H, Kim Y, Kwon H, Choi GE, Chi SG, Park HM, Lee H, Kim T
Molecular cancer 2024 Jul 4;23(1):136

Androgen receptor drives polyamine synthesis creating a vulnerability for prostate cancer.

Kumar R, Jonnatan S, Sanin DE, Vakkala V, Kadam A, Kumar S, Dalrymple SL, Zhao L, Foley J, Holbert CE, Nwafor A, Kittane S, Penner E, Apostolova P, Warner S, Dang CV, Toska E, Thompson EA, Isaacs JT, De Marzo AM, Pearce EL, Stewart TM, Casero RA, Denmeade SR, Sena LA
medRxiv : the preprint server for health sciences 2024 Dec 13;

AMD1 promotes breast cancer aggressiveness via a spermidine-eIF5A hypusination-TCF4 axis.

Liao R, Chen X, Cao Q, Bai L, Ma C, Dai Z, Dong C
Breast cancer research : BCR 2024 Apr 23;26(1):70

Inhibition of Polyamine Catabolism Reduces Cellular Senescence.

Uemura T, Matsunaga M, Yokota Y, Takao K, Furuchi T
International journal of molecular sciences 2023 Aug 29;24(17)

Progesterone and interferon tau regulate expression of polyamine enzymes during the ovine peri-implantation period†.

Halloran KM, Stenhouse C, Moses RM, Seo H, Johnson GA, Wu G, Bazer FW
Biology of reproduction 2022 May 17;106(5):865-878

Angiocrine polyamine production regulates adiposity.

Monelli E, Villacampa P, Zabala-Letona A, Martinez-Romero A, Llena J, Beiroa D, Gouveia L, Chivite I, Zagmutt S, Gama-Perez P, Osorio-Conles O, Muixi L, Martinez-Gonzalez A, Castillo SD, Martín-Martín N, Castel P, Valcarcel-Jimenez L, Garcia-Gonzalez I, Villena JA, Fernandez-Ruiz S, Serra D, Herrero L, Benedito R, Garcia-Roves P, Vidal J, Cohen P, Nogueiras R, Claret M, Carracedo A, Graupera M
Nature metabolism 2022 Mar;4(3):327-343

Genome-wide RNAi screen identifies novel players in human 60S subunit biogenesis including key enzymes of polyamine metabolism.

Dörner K, Badertscher L, Horváth B, Hollandi R, Molnár C, Fuhrer T, Meier R, Sárazová M, van den Heuvel J, Zamboni N, Horvath P, Kutay U
Nucleic acids research 2022 Mar 21;50(5):2872-2888

The KRAS-G12D mutation induces metabolic vulnerability in B-cell acute lymphoblastic leukemia.

Xu Y, Fang H, Chen Y, Tang Y, Sun H, Kong Z, Yang F, Kirschner-Schwabe R, Zhu L, Toker A, Xiao N, Zhou BS, Li H
iScience 2022 Mar 18;25(3):103881

Magnesium Supplementation Attenuates Ultraviolet-B-Induced Damage Mediated through Elevation of Polyamine Production in Human HaCaT Keratinocytes.

Shu S, Kobayashi M, Marunaka K, Yoshino Y, Goto M, Katsuta Y, Ikari A
Cells 2022 Jul 22;11(15)

Polyamine synthesis enzyme AMD1 is closely related to the tumorigenesis and prognosis of human breast cancer.

Gao H, Li H, Wang J, Xu C, Zhu Y, Tuluhong D, Li X, Wang S, Li J
Experimental cell research 2022 Aug 15;417(2):113235

Linkage of methionine addiction, histone lysine hypermethylation, and malignancy.

Yamamoto J, Inubushi S, Han Q, Tashiro Y, Sugisawa N, Hamada K, Aoki Y, Miyake K, Matsuyama R, Bouvet M, Clarke SG, Endo I, Hoffman RM
iScience 2022 Apr 15;25(4):104162

AMD1 upregulates hepatocellular carcinoma cells stemness by FTO mediated mRNA demethylation.

Bian X, Shi D, Xing K, Zhou H, Lu L, Yu D, Wu W
Clinical and translational medicine 2021 Mar;11(3):e352

Correlation of polyamines, acrolein-conjugated lysine and polyamine metabolic enzyme levels with age in human liver.

Uemura T, Akasaka Y, Ikegaya H
Heliyon 2020 Sep;6(9):e05031

Polyamine pathway activity promotes cysteine essentiality in cancer cells.

Zhang T, Bauer C, Newman AC, Uribe AH, Athineos D, Blyth K, Maddocks ODK
Nature metabolism 2020 Oct;2(10):1062-1076

Polyamine synthesis enzyme AMD1 is closely associated with tumorigenesis and prognosis of human gastric cancers.

Xu L, You X, Cao Q, Huang M, Hong LL, Chen XL, Lei L, Ling ZQ, Chen Y
Carcinogenesis 2020 Apr 22;41(2):214-222

mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer.

Zabala-Letona A, Arruabarrena-Aristorena A, Martín-Martín N, Fernandez-Ruiz S, Sutherland JD, Clasquin M, Tomas-Cortazar J, Jimenez J, Torres I, Quang P, Ximenez-Embun P, Bago R, Ugalde-Olano A, Loizaga-Iriarte A, Lacasa-Viscasillas I, Unda M, Torrano V, Cabrera D, van Liempd SM, Cendon Y, Castro E, Murray S, Revandkar A, Alimonti A, Zhang Y, Barnett A, Lein G, Pirman D, Cortazar AR, Arreal L, Prudkin L, Astobiza I, Valcarcel-Jimenez L, Zuñiga-García P, Fernandez-Dominguez I, Piva M, Caro-Maldonado A, Sánchez-Mosquera P, Castillo-Martín M, Serra V, Beraza N, Gentilella A, Thomas G, Azkargorta M, Elortza F, Farràs R, Olmos D, Efeyan A, Anguita J, Muñoz J, Falcón-Pérez JM, Barrio R, Macarulla T, Mato JM, Martinez-Chantar ML, Cordon-Cardo C, Aransay AM, Marks K, Baselga J, Tabernero J, Nuciforo P, Manning BD, Marjon K, Carracedo A
Nature 2017 Jul 6;547(7661):109-113

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The AMD1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human AMD1. This antibody recognizes human, mouse, rat antigen. The AMD1 antibody has been validated for the following applications: ELISA, IHC analysis.
Appendix: 11052-1-AP.pdf

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