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- Antibody Data
- Antigen structure
- References [22]
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- Validations
- Western blot [1]
- Immunoprecipitation [1]
- Immunohistochemistry [1]
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- Product number
- 11083-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11083-1-AP, RRID:AB_2121957
- Product name
- IFT57 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated IFT57 antibody (Cat. #11083-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat, Canine and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat, Canine
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references XIAP-mediated degradation of IFT88 disrupts HSC cilia to stimulate HSC activation and liver fibrosis.
PIH1D3-knockout rats exhibit full ciliopathy features and dysfunctional pre-assembly and loading of dynein arms in motile cilia.
Coordination of canonical and noncanonical Hedgehog signalling pathways mediated by WDR11 during primordial germ cell development.
Rabl2 GTP hydrolysis licenses BBSome-mediated export to fine-tune ciliary signaling.
Cooperation of the IFT-A complex with the IFT-B complex is required for ciliary retrograde protein trafficking and GPCR import.
Human IFT52 mutations uncover a novel role for the protein in microtubule dynamics and centrosome cohesion.
Dynein-2 intermediate chains play crucial but distinct roles in primary cilia formation and function.
FGFR1-mediated protocadherin-15 loading mediates cargo specificity during intraflagellar transport in inner ear hair-cell kinocilia.
BBSome function is required for both the morphogenesis and maintenance of the photoreceptor outer segment.
In Vitro Modeling Using Ciliopathy-Patient-Derived Cells Reveals Distinct Cilia Dysfunctions Caused by CEP290 Mutations.
The CEP19-RABL2 GTPase Complex Binds IFT-B to Initiate Intraflagellar Transport at the Ciliary Base.
IFT proteins spatially control the geometry of cleavage furrow ingression and lumen positioning.
Overall Architecture of the Intraflagellar Transport (IFT)-B Complex Containing Cluap1/IFT38 as an Essential Component of the IFT-B Peripheral Subcomplex.
Chibby functions to preserve normal ciliary morphology through the regulation of intraflagellar transport in airway ciliated cells.
Characterization of tetratricopeptide repeat-containing proteins critical for cilia formation and function.
Systematic proteomics of the VCP-UBXD adaptor network identifies a role for UBXN10 in regulating ciliogenesis.
DYNC2LI1 mutations broaden the clinical spectrum of dynein-2 defects.
Primary cilia signaling mediates intraocular pressure sensation.
The intraflagellar transport protein IFT27 promotes BBSome exit from cilia through the GTPase ARL6/BBS3.
The Cep63 paralogue Deup1 enables massive de novo centriole biogenesis for vertebrate multiciliogenesis.
BBS proteins interact genetically with the IFT pathway to influence SHH-related phenotypes.
A novel protein LZTFL1 regulates ciliary trafficking of the BBSome and Smoothened.
Hong R, Tan Y, Tian X, Huang Z, Wang J, Ni H, Yang J, Bu W, Yang S, Li T, Yu F, Zhong W, Sun T, Wang X, Li D, Liu M, Yang Y, Zhou J
EMBO reports 2024 Mar;25(3):1055-1074
EMBO reports 2024 Mar;25(3):1055-1074
PIH1D3-knockout rats exhibit full ciliopathy features and dysfunctional pre-assembly and loading of dynein arms in motile cilia.
Zhang T, Cui S, Xiong X, Liu Y, Cao Q, Xia XG, Zhou H
Frontiers in cell and developmental biology 2023;11:1282787
Frontiers in cell and developmental biology 2023;11:1282787
Coordination of canonical and noncanonical Hedgehog signalling pathways mediated by WDR11 during primordial germ cell development.
Lee J, Kim Y, Ataliotis P, Kim HG, Kim DW, Bennett DC, Brown NA, Layman LC, Kim SH
Scientific reports 2023 Jul 29;13(1):12309
Scientific reports 2023 Jul 29;13(1):12309
Rabl2 GTP hydrolysis licenses BBSome-mediated export to fine-tune ciliary signaling.
Duan S, Li H, Zhang Y, Yang S, Chen Y, Qiu B, Huang C, Wang J, Li J, Zhu X, Yan X
The EMBO journal 2021 Jan 15;40(2):e105499
The EMBO journal 2021 Jan 15;40(2):e105499
Cooperation of the IFT-A complex with the IFT-B complex is required for ciliary retrograde protein trafficking and GPCR import.
Kobayashi T, Ishida Y, Hirano T, Katoh Y, Nakayama K
Molecular biology of the cell 2021 Jan 1;32(1):45-56
Molecular biology of the cell 2021 Jan 1;32(1):45-56
Human IFT52 mutations uncover a novel role for the protein in microtubule dynamics and centrosome cohesion.
Dupont MA, Humbert C, Huber C, Siour Q, Guerrera IC, Jung V, Christensen A, Pouliet A, Garfa-Traoré M, Nitschké P, Injeyan M, Millar K, Chitayat D, Shannon P, Girisha KM, Shukla A, Mechler C, Lorentzen E, Benmerah A, Cormier-Daire V, Jeanpierre C, Saunier S, Delous M
Human molecular genetics 2019 Aug 15;28(16):2720-2737
Human molecular genetics 2019 Aug 15;28(16):2720-2737
Dynein-2 intermediate chains play crucial but distinct roles in primary cilia formation and function.
Vuolo L, Stevenson NL, Heesom KJ, Stephens DJ
eLife 2018 Oct 16;7
eLife 2018 Oct 16;7
FGFR1-mediated protocadherin-15 loading mediates cargo specificity during intraflagellar transport in inner ear hair-cell kinocilia.
Honda A, Kita T, Seshadri SV, Misaki K, Ahmed Z, Ladbury JE, Richardson GP, Yonemura S, Ladher RK
Proceedings of the National Academy of Sciences of the United States of America 2018 Aug 14;115(33):8388-8393
Proceedings of the National Academy of Sciences of the United States of America 2018 Aug 14;115(33):8388-8393
BBSome function is required for both the morphogenesis and maintenance of the photoreceptor outer segment.
Hsu Y, Garrison JE, Kim G, Schmitz AR, Searby CC, Zhang Q, Datta P, Nishimura DY, Seo S, Sheffield VC
PLoS genetics 2017 Oct;13(10):e1007057
PLoS genetics 2017 Oct;13(10):e1007057
In Vitro Modeling Using Ciliopathy-Patient-Derived Cells Reveals Distinct Cilia Dysfunctions Caused by CEP290 Mutations.
Shimada H, Lu Q, Insinna-Kettenhofen C, Nagashima K, English MA, Semler EM, Mahgerefteh J, Cideciyan AV, Li T, Brooks BP, Gunay-Aygun M, Jacobson SG, Cogliati T, Westlake CJ, Swaroop A
Cell reports 2017 Jul 11;20(2):384-396
Cell reports 2017 Jul 11;20(2):384-396
The CEP19-RABL2 GTPase Complex Binds IFT-B to Initiate Intraflagellar Transport at the Ciliary Base.
Kanie T, Abbott KL, Mooney NA, Plowey ED, Demeter J, Jackson PK
Developmental cell 2017 Jul 10;42(1):22-36.e12
Developmental cell 2017 Jul 10;42(1):22-36.e12
IFT proteins spatially control the geometry of cleavage furrow ingression and lumen positioning.
Taulet N, Vitre B, Anguille C, Douanier A, Rocancourt M, Taschner M, Lorentzen E, Echard A, Delaval B
Nature communications 2017 Dec 4;8(1):1928
Nature communications 2017 Dec 4;8(1):1928
Overall Architecture of the Intraflagellar Transport (IFT)-B Complex Containing Cluap1/IFT38 as an Essential Component of the IFT-B Peripheral Subcomplex.
Katoh Y, Terada M, Nishijima Y, Takei R, Nozaki S, Hamada H, Nakayama K
The Journal of biological chemistry 2016 May 20;291(21):10962-75
The Journal of biological chemistry 2016 May 20;291(21):10962-75
Chibby functions to preserve normal ciliary morphology through the regulation of intraflagellar transport in airway ciliated cells.
Siller SS, Burke MC, Li FQ, Takemaru K
Cell cycle (Georgetown, Tex.) 2015;14(19):3163-72
Cell cycle (Georgetown, Tex.) 2015;14(19):3163-72
Characterization of tetratricopeptide repeat-containing proteins critical for cilia formation and function.
Xu Y, Cao J, Huang S, Feng D, Zhang W, Zhu X, Yan X
PloS one 2015;10(4):e0124378
PloS one 2015;10(4):e0124378
Systematic proteomics of the VCP-UBXD adaptor network identifies a role for UBXN10 in regulating ciliogenesis.
Raman M, Sergeev M, Garnaas M, Lydeard JR, Huttlin EL, Goessling W, Shah JV, Harper JW
Nature cell biology 2015 Oct;17(10):1356-69
Nature cell biology 2015 Oct;17(10):1356-69
DYNC2LI1 mutations broaden the clinical spectrum of dynein-2 defects.
Kessler K, Wunderlich I, Uebe S, Falk NS, Gießl A, Brandstätter JH, Popp B, Klinger P, Ekici AB, Sticht H, Dörr HG, Reis A, Roepman R, Seemanová E, Thiel CT
Scientific reports 2015 Jul 1;5:11649
Scientific reports 2015 Jul 1;5:11649
Primary cilia signaling mediates intraocular pressure sensation.
Luo N, Conwell MD, Chen X, Kettenhofen CI, Westlake CJ, Cantor LB, Wells CD, Weinreb RN, Corson TW, Spandau DF, Joos KM, Iomini C, Obukhov AG, Sun Y
Proceedings of the National Academy of Sciences of the United States of America 2014 Sep 2;111(35):12871-6
Proceedings of the National Academy of Sciences of the United States of America 2014 Sep 2;111(35):12871-6
The intraflagellar transport protein IFT27 promotes BBSome exit from cilia through the GTPase ARL6/BBS3.
Liew GM, Ye F, Nager AR, Murphy JP, Lee JS, Aguiar M, Breslow DK, Gygi SP, Nachury MV
Developmental cell 2014 Nov 10;31(3):265-278
Developmental cell 2014 Nov 10;31(3):265-278
The Cep63 paralogue Deup1 enables massive de novo centriole biogenesis for vertebrate multiciliogenesis.
Zhao H, Zhu L, Zhu Y, Cao J, Li S, Huang Q, Xu T, Huang X, Yan X, Zhu X
Nature cell biology 2013 Dec;15(12):1434-44
Nature cell biology 2013 Dec;15(12):1434-44
BBS proteins interact genetically with the IFT pathway to influence SHH-related phenotypes.
Zhang Q, Seo S, Bugge K, Stone EM, Sheffield VC
Human molecular genetics 2012 May 1;21(9):1945-53
Human molecular genetics 2012 May 1;21(9):1945-53
A novel protein LZTFL1 regulates ciliary trafficking of the BBSome and Smoothened.
Seo S, Zhang Q, Bugge K, Breslow DK, Searby CC, Nachury MV, Sheffield VC
PLoS genetics 2011 Nov;7(11):e1002358
PLoS genetics 2011 Nov;7(11):e1002358
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse retina tissue were subjected to SDS PAGE followed by western blot with 11083-1-AP(IFT57 antibody) at dilution of 1:1000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-IFT57 (IP:11083-1-AP, 5ug; Detection:11083-1-AP 1:800) with HEK-293 cells lysate 2000ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The IFT57 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human IFT57. This antibody recognizes human,mouse,rat antigen. The IFT57 antibody has been validated for the following applications: ELISA, WB, IHC, IP analysis.
