BS7042

antibody from Bioworld Technology, Inc
Targeting: KLK8 HNP, neuropsin, ovasin, PRSS19, TADG14
Provider product page for BS7042

Antibody data

Product number
BS7042 - Provider product page
Provider
Bioworld Technology, Inc
Product name
Cleaved KLK8 (V33) polyclonal antibody
Antibody type
Polyclonal
Antigen
Synthetic peptide, corresponding to amino acids 11-60 of Human KLK8.
Description
Kallikreins (KLKs) belong to the serine protease family of proteolytic enzymes. Kallikrein-8 (KLK8), also called neuropsin precursor, ovasin or serine protease 19, is a 260 amino acid secreted protein involved in hippocampal plasticity. Two isoforms exist for this protein. Isoform 1 is the primary form of KLK8 found predominantly in the pancreas. Isoform 2 contains an additional 46 amino acids after amino acid 23 and is predominantly expressed in adult brain and hippocampus. Isoform 2 is not common to the mouse homolog or other primate homologs. In humans, the T to A mutation (c.71-127T>A) leads to the splice variant seen in the human brain. Both isoforms are detected in fetal brain and placenta. In some cancer cells, KLK8 expression can suppress tumor cell invasiveness and lead to a favorable clinical outcome.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
KLK8 protein structure - BS7042 shown in red.