RA0134

antibody from Oursmab

Targeting: CD96 TACTILE

Western blot (Supportive data in Antibodypedia)

ELISA (Supportive data in Antibodypedia)

Immunocytochemistry (Recommended by provider)

Flow cytometry (Recommended by provider)

Functional assay (Recommended by provider)

Antibody Data

Product number

RA0134

Provider

Oursmab

Product name

Nelistotug (Biosimilar Reference Antibody) (CD96)

Antibody type

Monoclonal

Description

Nelistotug (also known as GSK6097608) is a human IgG1-kappa monoclonal antibody that specifically targets CD96 (T-cell-activated increased late expression, TACTILE), an immune checkpoint receptor belonging to the immunoglobulin superfamily. As an IgG1 isotype, it is designed to engage immune effector functions such as antibody-dependent cellular cytotoxicity (ADCC) and/or block receptor-ligand interactions. CD96 is primarily expressed on natural killer (NK) cells and T cells, where it binds to ligands such as CD155 (PVR) and CD111 (Nectin-1), often transmitting inhibitory signals. By binding to CD96, nelistotug aims to block these interactions, thereby reversing immune suppression and enhancing NK-cell and T-cell anti-tumor activity. It is being developed as an immune checkpoint inhibitor for the treatment of advanced solid tumors.

Reactivity

Human

Isotype

IgG

Vial size

100 ¦Ìg,1 mg,5 mg,10 mg,25 mg,50 mg,100 mg

Concentration

Bottled at the concentration indicated on the vial.

Storage

Store at -20¡ãC or -80¡ãC. Avoid repeated freeze.

Western blot

Supportive validation

Submitted by

Oursmab (provider)

Main image

Experimental details

Nelistotug (Biosimilar Reference Antibody) (CD96)-RA0134-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.

ELISA

Supportive validation

Submitted by

Oursmab (provider)

Main image

Experimental details

ELISA plate pre-coated Antigen protein, can bind Nelistotug (Biosimilar Reference Antibody) (CD96)-RA0134 in a linear range of 0.18¨C15 ng/mL.