NOXA1

This gene encodes a protein which activates NADPH oxidases, enzymes which catalyze a reaction generating reactive oxygen species. The encoded protein contains four N-terminal tetratricopeptide domains and a C-terminal Src homology 3 domain. Interaction between the encoded protein and proteins in the oxidase regulatory complex occur via the tetratricopeptide domains. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Description

NADPH oxidase activator 1

Tissue specificity

Low tissue specificity

Subcell location

Vesicles

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

9 (137423350 - 137434406)

Ensembl ID

ENSG00000188747  (ver. 103.38)

Orthologs

Mouse Noxa1: ENSMUSG00000036805

UniProt

Q86UR1

neXtProt

NX_Q86UR1

Human splice variants
Mouse splice variants

Protein structure