Antibody data
- Antibody Data
- Antigen structure
- References [9]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
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Validation data
Reference
Comment
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- Product number
- 17195-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#17195-1-AP, RRID:AB_2143221
- Product name
- MGMT antibody
- Antibody type
- Polyclonal
- Description
- MGMT antibody (Cat. #17195-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Targeting JUN, CEBPB, and HDAC3: A Novel Strategy to Overcome Drug Resistance in Hypoxic Glioblastoma.
FoxD2-AS1 is a prognostic factor in glioma and promotes temozolomide resistance in a O6-methylguanine-DNA methyltransferase-dependent manner.
Novel predictive epigenetic signature for temozolomide in non-G-CIMP glioblastomas.
DNA damage triggers tubular endoplasmic reticulum extension to promote apoptosis by facilitating ER-mitochondria signaling.
Knockdown of SALL4 expression using RNA interference induces cell cycle arrest, enhances early apoptosis, inhibits invasion and increases chemosensitivity to temozolomide in U251 glioma cells.
Renal cell carcinoma with synchronous ipsilateral urothelial carcinoma of the renal pelvis.
Enhancing the cytotoxicity of chemoradiation with radiation-guided delivery of anti-MGMT morpholino oligonucleotides in non-methylated solid tumors.
GANT61, a GLI inhibitor, sensitizes glioma cells to the temozolomide treatment.
Global and MGMT promoter hypomethylation independently associated with genomic instability of lymphocytes in subjects exposed to high-dose polycyclic aromatic hydrocarbon.
Gao Y, Liu B, Feng L, Sun B, He S, Yang Y, Wu G, E G, Liu C, Gao Y, Zhang E, Zhu B
Frontiers in oncology 2019;9:33
Frontiers in oncology 2019;9:33
FoxD2-AS1 is a prognostic factor in glioma and promotes temozolomide resistance in a O6-methylguanine-DNA methyltransferase-dependent manner.
Shangguan W, Lv X, Tian N
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2019 Nov;23(6):475-482
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2019 Nov;23(6):475-482
Novel predictive epigenetic signature for temozolomide in non-G-CIMP glioblastomas.
Yin AA, He YL, Etcheverry A, Liu YH, Aubry M, Barnholtz-Sloan J, Liu BL, Mosser J, Lu ZF, Zhang X
Clinical epigenetics 2019 May 14;11(1):76
Clinical epigenetics 2019 May 14;11(1):76
DNA damage triggers tubular endoplasmic reticulum extension to promote apoptosis by facilitating ER-mitochondria signaling.
Zheng P, Chen Q, Tian X, Qian N, Chai P, Liu B, Hu J, Blackstone C, Zhu D, Teng J, Chen J
Cell research 2018 Aug;28(8):833-854
Cell research 2018 Aug;28(8):833-854
Knockdown of SALL4 expression using RNA interference induces cell cycle arrest, enhances early apoptosis, inhibits invasion and increases chemosensitivity to temozolomide in U251 glioma cells.
Zhang L, Yan Y, Jiang Y, Qian J, Jiang L, Hu G, Lu Y, Luo C
Oncology letters 2017 Oct;14(4):4263-4269
Oncology letters 2017 Oct;14(4):4263-4269
Renal cell carcinoma with synchronous ipsilateral urothelial carcinoma of the renal pelvis.
Lu Q, Zhuang J, Guo H
Oncology letters 2017 Jun;13(6):4521-4525
Oncology letters 2017 Jun;13(6):4521-4525
Enhancing the cytotoxicity of chemoradiation with radiation-guided delivery of anti-MGMT morpholino oligonucleotides in non-methylated solid tumors.
Ambady P, Wu YJ, Walker JM, Kersch C, Pagel MA, Woltjer RL, Fu R, Muldoon LL, Neuwelt EA
Cancer gene therapy 2017 Aug;24(8):348-357
Cancer gene therapy 2017 Aug;24(8):348-357
GANT61, a GLI inhibitor, sensitizes glioma cells to the temozolomide treatment.
Li J, Cai J, Zhao S, Yao K, Sun Y, Li Y, Chen L, Li R, Zhai X, Zhang J, Jiang C
Journal of experimental & clinical cancer research : CR 2016 Nov 28;35(1):184
Journal of experimental & clinical cancer research : CR 2016 Nov 28;35(1):184
Global and MGMT promoter hypomethylation independently associated with genomic instability of lymphocytes in subjects exposed to high-dose polycyclic aromatic hydrocarbon.
Duan H, He Z, Ma J, Zhang B, Sheng Z, Bin P, Cheng J, Niu Y, Dong H, Lin H, Dai Y, Zhu B, Chen W, Xiao Y, Zheng Y
Archives of toxicology 2013 Nov;87(11):2013-2022
Archives of toxicology 2013 Nov;87(11):2013-2022
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Jurkat cells were subjected to SDS PAGE followed by western blot with 17195-1-AP(MGMT antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human kidney using 17195-1-AP(MGMT antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The MGMT antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human MGMT. This antibody recognizes human antigen. The MGMT antibody has been validated for the following applications: ELISA, WB, IHC analysis.