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- Product number
- ABIN151202 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-O6-Methylguanine-DNA-Methyltransferase (MGMT) antibody
- Antibody type
- Monoclonal
- Description
- Protein G purified
- Reactivity
- Human
- Host
- Mouse
- Isotype
- IgG
- Antibody clone number
- MT 23-2
- Vial size
- 0.1 mL
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
- Handling
- Avoid freeze-thaw cycles
Submitted references MGMT gene variants, temozolomide myelotoxicity and glioma risk. A concise literature survey including an illustrative case.
Temozolomide promotes genomic and phenotypic changes in glioblastoma cells.
IDH-mutant glioma specific association of rs55705857 located at 8q24.21 involves MYC deregulation.
HSP90 regulates DNA repair via the interaction between XRCC1 and DNA polymerase β.
Impact of O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation and MGMT expression on dacarbazine resistance of Hodgkin's lymphoma cells.
Human O6 -methylguanine-DNA methyltransferase containing C145A does not prevent hepatocellular carcinoma in C3HeB/FeJ transgenic mice.
BMP2 sensitizes glioblastoma stem-like cells to Temozolomide by affecting HIF-1α stability and MGMT expression.
MGMT expression and promoter methylation status may depend on the site of surgical sample collection within glioblastoma: a possible pitfall in stratification of patients?
[Induction of repair enzyme O6-methylguanine-DNA methyltransferase gene expression under the influence of cytokine EMAP II in human cells in vitro].
N-methylpurine DNA glycosylase and DNA polymerase beta modulate BER inhibitor potentiation of glioma cells to temozolomide.
Intratumoral hypoxic gradient drives stem cells distribution and MGMT expression in glioblastoma.
Mitochondrial targeting of human O6-methylguanine DNA methyltransferase protects against cell killing by chemotherapeutic alkylating agents.
O6-methylguanine-DNA methyltransferase gene: epigenetic silencing and prognostic value in head and neck squamous cell carcinoma.
Human-yeast chimeric repair protein protects mammalian cells against alkylating agents: enhancement of MGMT protection.
Protection and in vivo selection of hematopoietic stem cells using temozolomide, O6-benzylguanine, and an alkyltransferase-expressing retroviral vector.
Differential degradation rates of inactivated alkyltransferase in blood mononuclear cells and tumors of patients after treatment with O(6)-benzylguanine.
A gene hypermethylation profile of human cancer.
Antitumor activity of temozolomide combined with irinotecan is partly independent of O6-methylguanine-DNA methyltransferase and mismatch repair phenotypes in xenograft models.
A specific CpG methylation pattern of the MGMT promoter region associated with reduced MGMT expression in primary colorectal cancers.
Role of O6-methylguanine-DNA methyltransferase in the resistance of pancreatic tumors to DNA alkylating agents.
Altinoz MA, Elmaci I, Bolukbasi FH, Ekmekci CG, Yenmis G, Sari R, Sav A
Journal of chemotherapy (Florence, Italy) 2017 Aug;29(4):238-244
Journal of chemotherapy (Florence, Italy) 2017 Aug;29(4):238-244
Temozolomide promotes genomic and phenotypic changes in glioblastoma cells.
Stepanenko AA, Andreieva SV, Korets KV, Mykytenko DO, Baklaushev VP, Huleyuk NL, Kovalova OA, Kotsarenko KV, Chekhonin VP, Vassetzky YS, Avdieiev SS, Dmitrenko VV
Cancer cell international 2016;16:36
Cancer cell international 2016;16:36
IDH-mutant glioma specific association of rs55705857 located at 8q24.21 involves MYC deregulation.
Oktay Y, Ülgen E, Can Ö, Akyerli CB, Yüksel Ş, Erdemgil Y, Durası IM, Henegariu OI, Nanni EP, Selevsek N, Grossmann J, Erson-Omay EZ, Bai H, Gupta M, Lee W, Turcan Ş, Özpınar A, Huse JT, Sav MA, Flanagan A, Günel M, Sezerman OU, Yakıcıer MC, Pamir MN, Özduman K
Scientific reports 2016 Jun 10;6:27569
Scientific reports 2016 Jun 10;6:27569
HSP90 regulates DNA repair via the interaction between XRCC1 and DNA polymerase β.
Fang Q, Inanc B, Schamus S, Wang XH, Wei L, Brown AR, Svilar D, Sugrue KF, Goellner EM, Zeng X, Yates NA, Lan L, Vens C, Sobol RW
Nature communications 2014 Nov 26;5:5513
Nature communications 2014 Nov 26;5:5513
Impact of O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation and MGMT expression on dacarbazine resistance of Hodgkin's lymphoma cells.
Kewitz S, Stiefel M, Kramm CM, Staege MS
Leukemia research 2014 Jan;38(1):138-43
Leukemia research 2014 Jan;38(1):138-43
Human O6 -methylguanine-DNA methyltransferase containing C145A does not prevent hepatocellular carcinoma in C3HeB/FeJ transgenic mice.
Herzig MC, Hildreth K, Huamani J, Perez M, Goins BA, McMahan CA, Reddick RL, Walter CA
Molecular carcinogenesis 2013 Apr;52(4):275-85
Molecular carcinogenesis 2013 Apr;52(4):275-85
BMP2 sensitizes glioblastoma stem-like cells to Temozolomide by affecting HIF-1α stability and MGMT expression.
Persano L, Pistollato F, Rampazzo E, Della Puppa A, Abbadi S, Frasson C, Volpin F, Indraccolo S, Scienza R, Basso G
Cell death & disease 2012 Oct 18;3:e412
Cell death & disease 2012 Oct 18;3:e412
MGMT expression and promoter methylation status may depend on the site of surgical sample collection within glioblastoma: a possible pitfall in stratification of patients?
Della Puppa A, Persano L, Masi G, Rampazzo E, Sinigaglia A, Pistollato F, Denaro L, Barzon L, Palù G, Basso G, Scienza R, d'Avella D
Journal of neuro-oncology 2012 Jan;106(1):33-41
Journal of neuro-oncology 2012 Jan;106(1):33-41
[Induction of repair enzyme O6-methylguanine-DNA methyltransferase gene expression under the influence of cytokine EMAP II in human cells in vitro].
Lylo VV, Matsevich LL, Kotsarenko EV, Babenko LA, Korneliuk AI, Sukhorada EM, Lukash LL
TSitologiia i genetika 2011 Nov-Dec;45(6):53-60
TSitologiia i genetika 2011 Nov-Dec;45(6):53-60
N-methylpurine DNA glycosylase and DNA polymerase beta modulate BER inhibitor potentiation of glioma cells to temozolomide.
Tang JB, Svilar D, Trivedi RN, Wang XH, Goellner EM, Moore B, Hamilton RL, Banze LA, Brown AR, Sobol RW
Neuro-oncology 2011 May;13(5):471-86
Neuro-oncology 2011 May;13(5):471-86
Intratumoral hypoxic gradient drives stem cells distribution and MGMT expression in glioblastoma.
Pistollato F, Abbadi S, Rampazzo E, Persano L, Della Puppa A, Frasson C, Sarto E, Scienza R, D'avella D, Basso G
Stem cells (Dayton, Ohio) 2010 May;28(5):851-62
Stem cells (Dayton, Ohio) 2010 May;28(5):851-62
Mitochondrial targeting of human O6-methylguanine DNA methyltransferase protects against cell killing by chemotherapeutic alkylating agents.
Cai S, Xu Y, Cooper RJ, Ferkowicz MJ, Hartwell JR, Pollok KE, Kelley MR
Cancer research 2005 Apr 15;65(8):3319-27
Cancer research 2005 Apr 15;65(8):3319-27
O6-methylguanine-DNA methyltransferase gene: epigenetic silencing and prognostic value in head and neck squamous cell carcinoma.
Zuo C, Ai L, Ratliff P, Suen JY, Hanna E, Brent TP, Fan CY
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2004 Jun;13(6):967-75
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2004 Jun;13(6):967-75
Human-yeast chimeric repair protein protects mammalian cells against alkylating agents: enhancement of MGMT protection.
Roth TJ, Xu Y, Luo M, Kelley MR
Cancer gene therapy 2003 Aug;10(8):603-10
Cancer gene therapy 2003 Aug;10(8):603-10
Protection and in vivo selection of hematopoietic stem cells using temozolomide, O6-benzylguanine, and an alkyltransferase-expressing retroviral vector.
Sawai N, Zhou S, Vanin EF, Houghton P, Brent TP, Sorrentino BP
Molecular therapy : the journal of the American Society of Gene Therapy 2001 Jan;3(1):78-87
Molecular therapy : the journal of the American Society of Gene Therapy 2001 Jan;3(1):78-87
Differential degradation rates of inactivated alkyltransferase in blood mononuclear cells and tumors of patients after treatment with O(6)-benzylguanine.
Liu L, Spiro TP, Qin X, Majka S, Haaga J, Schupp J, Willson JK, Gerson SL
Clinical cancer research : an official journal of the American Association for Cancer Research 2001 Aug;7(8):2318-24
Clinical cancer research : an official journal of the American Association for Cancer Research 2001 Aug;7(8):2318-24
A gene hypermethylation profile of human cancer.
Esteller M, Corn PG, Baylin SB, Herman JG
Cancer research 2001 Apr 15;61(8):3225-9
Cancer research 2001 Apr 15;61(8):3225-9
Antitumor activity of temozolomide combined with irinotecan is partly independent of O6-methylguanine-DNA methyltransferase and mismatch repair phenotypes in xenograft models.
Houghton PJ, Stewart CF, Cheshire PJ, Richmond LB, Kirstein MN, Poquette CA, Tan M, Friedman HS, Brent TP
Clinical cancer research : an official journal of the American Association for Cancer Research 2000 Oct;6(10):4110-8
Clinical cancer research : an official journal of the American Association for Cancer Research 2000 Oct;6(10):4110-8
A specific CpG methylation pattern of the MGMT promoter region associated with reduced MGMT expression in primary colorectal cancers.
Herfarth KK, Brent TP, Danam RP, Remack JS, Kodner IJ, Wells SA Jr, Goodfellow PJ
Molecular carcinogenesis 1999 Feb;24(2):90-8
Molecular carcinogenesis 1999 Feb;24(2):90-8
Role of O6-methylguanine-DNA methyltransferase in the resistance of pancreatic tumors to DNA alkylating agents.
Kokkinakis DM, Ahmed MM, Delgado R, Fruitwala MM, Mohiuddin M, Albores-Saavedra J
Cancer research 1997 Dec 1;57(23):5360-8
Cancer research 1997 Dec 1;57(23):5360-8
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