PP-B0422-00

antibody from Novus Biologicals

Targeting: EHMT1 bA188C12.1, EHMT1-IT1, Eu-HMTase1, FLJ12879, FLJ40292, KIAA1876, KMT1D

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunoprecipitation (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

PP-B0422-00

Provider

Novus Biologicals

Product name

Mouse Monoclonal GLP/EHMT1 Antibody

Antibody type

Monoclonal

Description

Protein A or G purified from hybridoma culture supernatant. This antibody specifically recognizes mouse GLP and cross-reacts with human GLP. Not yet tested in other species.

Reactivity

Human, Mouse

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Vial size

100 ug

Storage

This antibody is stable for greater than six months when held at -20 degreesC in a manual defrost freezer or at -70 degreesC. Upon thawing, the antibody can be stored at 2-8 degreesC for at least 1 month without detectable loss of activity. Avoid repeated freeze-thaw cycles.

References

Submitted references

G9a regulates temporal preimplantation developmental program and lineage segregation in blastocyst.

Zylicz JJ, Borensztein M, Wong FC, Huang Y, Lee C, Dietmann S, Surani MA
eLife 2018 May 10;7

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Co-repressor CBFA2T2 regulates pluripotency and germline development.

Tu S, Narendra V, Yamaji M, Vidal SE, Rojas LA, Wang X, Kim SY, Garcia BA, Tuschl T, Stadtfeld M, Reinberg D
Nature 2016 Jun 16;534(7607):387-90

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Chromatin landscape defined by repressive histone methylation during oligodendrocyte differentiation.

Liu J, Magri L, Zhang F, Marsh NO, Albrecht S, Huynh JL, Kaur J, Kuhlmann T, Zhang W, Slesinger PA, Casaccia P
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Jan 7;35(1):352-65

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Inhibition of euchromatic histone methyltransferase 1 and 2 sensitizes chronic myeloid leukemia cells to interferon treatment.

Loh SW, Ng WL, Yeo KS, Lim YY, Ea CK
PloS one 2014;9(7):e103915

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The methyltransferase G9a regulates HoxA9-dependent transcription in AML.

Lehnertz B, Pabst C, Su L, Miller M, Liu F, Yi L, Zhang R, Krosl J, Yung E, Kirschner J, Rosten P, Underhill TM, Jin J, Hébert J, Sauvageau G, Humphries RK, Rossi FM
Genes & development 2014 Feb 15;28(4):317-27

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EHMT1 protein binds to nuclear factor-κB p50 and represses gene expression.

Ea CK, Hao S, Yeo KS, Baltimore D
The Journal of biological chemistry 2012 Sep 7;287(37):31207-17

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The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset.

Ceol CJ, Houvras Y, Jane-Valbuena J, Bilodeau S, Orlando DA, Battisti V, Fritsch L, Lin WM, Hollmann TJ, Ferré F, Bourque C, Burke CJ, Turner L, Uong A, Johnson LA, Beroukhim R, Mermel CH, Loda M, Ait-Si-Ali S, Garraway LA, Young RA, Zon LI
Nature 2011 Mar 24;471(7339):513-7

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Control of cognition and adaptive behavior by the GLP/G9a epigenetic suppressor complex.

Schaefer A, Sampath SC, Intrator A, Min A, Gertler TS, Surmeier DJ, Tarakhovsky A, Greengard P
Neuron 2009 Dec 10;64(5):678-91

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DNA methylation in ES cells requires the lysine methyltransferase G9a but not its catalytic activity.

Dong KB, Maksakova IA, Mohn F, Leung D, Appanah R, Lee S, Yang HW, Lam LL, Mager DL, Schübeler D, Tachibana M, Shinkai Y, Lorincz MC
The EMBO journal 2008 Oct 22;27(20):2691-701