Antibody data
- Antibody Data
- Antigen structure
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- Product number
- CABT-B9300 - Provider product page
- Provider
- Creative Diagnostics
- Product name
- Mouse anti-Human PRK monoclonal antibody, clone C48-3
- Antibody type
- Monoclonal
- Description
- PRK (proliferation-related kinase) is a serine/threonine kinase with significant homology to members of the polo family of protein kinases (e.g., mouse fnk/snk, human and mouse plk). There are two domains in the polo family kinases, an amino-terminal kinase domain and a carboxylterminal regulatory domain. Polo kinases have been previously implicated in cell division. Tissue specific expression of PRK mRNA is normally fairly restricted, but includes human placenta, and to a lesser degree, ovaries and peripheral blood leukocytes. PRK mRNA is generally undetectable in many cell lines but may be induced in some cell types by mitogens or following addition of serum to previously serum-deprived cells. PRK expression is tightly regulated at various levels during different stages of the cell cycle. For example, PRK kinase activity in lung fibroblasts is relatively low during mitosis, G1, and G1/S
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