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- Antibody Data
- Antigen structure
- References [1131]
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- Product number
- 67763-1-Ig - Provider product page
- Provider
- Proteintech Group
- Product name
- GPX4 antibody
- Antibody type
- Monoclonal
- Description
- GPX4 antibody (Cat. #67763-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human, mouse, rat, rabbit, pig and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat, Porcine, Rabbit
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 3F5G5
- Vial size
- 20ul, 150ul
Submitted references IL-22 inhibits ferroptosis and attenuates ischemia-reperfusion-induced acute kidney injury: Association with activation of the P62-Keap1-Nrf2 signaling pathway.
Exosomal lncRNA FENDRR Orchestrates Immune Remodelling and Ferroptosis in the Comorbidity of Lung Cancer and Type 1 Myocardial Infarction.
Aloperine Induces Ferroptosis of Colorectal Cancer Cells via the Nrf2 Pathway.
Actinidia chinensis Planch Root extracts trigger ferroptosis in colorectal cancer via the p53/SLC7A11/GPX4 axis.
The contribution of ferroptosis to the epithelial-mesenchymal transition phenotype in models of age-related macular degeneration.
Identification of potential ferroptosis-related biomarkers in proliferative vitreoretinopathy based on machine learning.
Monitoring early micro-oxidation under refrigeration: iron and oxidative markers predict quality loss in grass carp.
Self-amplifying nanomedicine reprograms redox metabolism to trigger immunogenic ferroptosis in colon cancer: multiomics identifies AMPD3 as a novel regulator.
Genetically engineered Escherichia coli Nissle 1917 enabling on-site melanin synthesis attenuates radiation enteritis through ferroptosis inhibition and gut microbiota modulation.
Cysteine imaging reveals early redox dysregulation and identifies gnetol as a ferroptosis-modulating agent in doxorubicin cardiotoxicity.
Processed phellodendri Chinensis cortex attenuates diabetic nephropathy via ferroptosis inhibition through GPX4/SLC7A11/Nrf2/HO-1 signaling pathway.
Regulation of sepsis-associated acute kidney injury by ELAVL1 through USP14/NCOA4-mediated ferroptosis in renal tubular epithelial cells.
Trimethyltin chloride triggers ferroptosis in myocardial injury: mitochondria-dependent protection by luteolin.
Multi-omics reveals that 4'-O-β-D-glucosyl-5-O-methylvisamminol ameliorates acute liver injury by modulating the miR-30e-3p/Tfrc axis and a multi-dimensional network of ferroptosis, inflammation, metabolism, and gut microbiota.
Ubiquitin-Specific Protease 45 Inhibits Lung Adenocarcinoma Ferroptosis by Regulating Ubiquitination and Stability of Glutathione Peroxidase 4.
A Blood-Triggered Adhesive Hydrogel Loaded with Reactive Oxygen Species-Responsive Liposomes for the Treatment of Acute Kidney Injury.
NUP62 promotes breast cancer progression and inhibits ferroptosis by stabilizing NRF2 in a KEAP1-dependent way.
Glutathione metabolic reprogramming by ferroptosis inducers potentiates cuproptosis and antitumor immunity in osteosarcoma.
Novel Dual-Pharmacophore TrxR Inhibitors Integrating Ferroptosis and Antitumor Immunity: A Closed-Loop Strategy for TIME Remodeling.
In situ delivery of JPH203 via camptothecin-peptide conjugate nanoassemblies to trigger ferroptosis in triple-negative breast cancer.
Squalene epoxidase promotes paraquat-induced pulmonary toxicity through endoplasmic reticulum-mediated ferroptosis.
ENO1 inhibition synergizes with chidamide to induce ferroptosis in PTCL-NOS through metabolic remodeling.
EGR1 promotes ferroptosis in endometriosis through transcriptional activation of HMOX1.
Concurrent Ferroptosis and Apoptosis in Resveratrol-Treated Glioblastoma Cells: Relevance With NRF2 Downregulation and Oxidative Stress.
A multifunctional hydrogel promotes diabetic wound healing by remodeling iron balance and energy metabolism.
c-MAF Transcriptionally Activates Slc40a1 to Repress Ferroptosis in Sepsis-Associated Encephalopathy.
Acceleration of Lactate Uptake and Utilization Contributes to Neuroprotective Action of FGF21 Involved in Naturally Aging Mice.
Rhein-Emodin Combination Activates UQCRC1 to Attenuate MPP(+)-Induced Ferroptosis in Dopaminergic Neurons.
M2 macrophage-derived exosome nanoplatform for targeted H(2)S delivery to alleviate hepatic ischemia-reperfusion injury via synergistic anti-oxidative, anti-inflammatory, and anti-ferroptotic effects.
Apatinib and silver nanoparticles synergize against gastric cancer through the PI3K/Akt signaling pathway-mediated ferroptosis.
Astaxanthin alleviates DSS-induced ulcerative colitis in mice associated with Nrf2-mediated ferroptosis independently of gut microbiota modulation.
L-theanine alleviates muscle oxidative damage by improving mitochondrial function, maintaining calcium homeostasis, and inhibiting ferroptosis.
Copper-induced duodenal injury: Unveiling the dual role of cuproptosis and ferroptosis via the FDX1/GPX4 axis.
Mast Cell-Derived CXCL4: A Key Mediator of Ferroptosis and Cardiac Damage in Septic Cardiomyopathy.
M6A reader IGF2BP3 stabili1zes SLC7A11 to antagonize ferroptosis and promote gastric tumorigenesis.
Quercetin-4'-O-β-D-glucopyranoside inhibits ferroptosis though SIRT5-mediated desuccinylation of TFR1 in diabetic nephropathy.
RRM2/GCH1 signaling decreased cisplatin sensitivity in cervical cancer by modulating the ferroptosis process.
Trolline attenuates diabetic vascular injury by regulating SLC7A11-mediated ferroptosis and mitochondrial dysfunction.
Curcumin protects against difenoconazole-induced kidney injury in carp by inhibiting ferroptosis through the Nrf2/GPX4 axis.
Polystyrene Nanoplastics induced placental toxicology by activating Keap1-mediated ferroptosis via METTL3-dependent m6A methylation.
Cofilin-1 Exacerbates Tau-Induced Mitochondrial Damage, Oxidative Stress, and Apoptosis in Alzheimer's Disease.
A new candidate tumor suppressor tRF-Ser inhibits gastric cancer progression by regulating the CNBP/HSPA8 axis.
[Different Astragalus medicinal pairs improve diabetic nephropathy in mice by regulating lipid peroxidation through PTGS2].
Mechanistic Study of HDAC6 Regulation of Iron Death in Ulcerative Colitis.
Disruption of iron homeostasis by HERC2-FTL axis leads to chondrocyte loss and exacerbates osteoarthritis.
Liproxstatin-1 Attenuates Retinal Ischemia-Reperfusion Injury by Suppressing EGR1-Mediated Ferroptosis.
Omics insights into MYBL2-promoted cancer stem-like cells driving ferroptosis resistance in hepatocellular carcinoma.
IRX4204 sensitizes multiple myeloma to ferroptosis and improves lenalidomide efficacy through the HMOX1-GPX4 axis.
Ginsenoside Rh4 Triggers Ferroptosis in Lung Cancer: Targeting KEAP1/NRF2/HO-1 and Remodeling Gut Microbiota for Butyrate-Mediated ATF3 Activation.
Microneedle patches deliver targeted GLP-1RAs-loaded nanoparticles for the treatment of rheumatoid arthritis.
HMGB1-mediated enhancement of glycolysis activates hepatic stellate cells by inhibiting ferroptosis in alcoholic hepatic fibrosis.
Study on the effects and mechanisms of M2 macrophages on PYCR1-promoted biological behavior of hepatocellular carcinoma cells.
CXCL12 Promotes Peripheral Nerve Injury Repair by Inhibiting the Ferroptosis-Inflammation Axis via the ERK/Nrf2 Pathway.
ROS-Responsive Prodrug Containing Dihydroartemisinin and Cinnamaldehyde for the Potential Treatment of Nonalcoholic Steatohepatitis.
MAPK14/SLC7A11/GPX4 axis dysregulation drives podocyte ferroptosis via mediating glycerophospholipid metabolism.
Paeoniflorin mitigates myocardial hypertrophy by regulating mitophagy and ferroptosis mediated by mitochondria-associated AMPK-Parkin-ACSL4 pathway.
Targeting HIF-1α promotes ferroptosis and boosts antitumor immunity in MSS colorectal cancer.
A mitochondria-targeted nanoantioxidant restores alveolar bone homeostasis in periodontitis by quenching ROS and suppressing the cGAS-STING pathway.
Enhancing exosomes efficacy with engineered nanozymes for a multi-targeted combination strategy in osteoarthritis treatment.
Phycocyanin-functionalized selenium nanoparticles attenuate osteoarthritis through ferroptosis suppression and modulation of the MAPK pathway.
Bufotenidine attenuates astrocyte ferroptosis in depressive-like behaviors through targeting GluA1 to reduce neuronal lipid synthesis.
METTL3-mediated m(6)A modification contributes to anlotinib resistance in osteosarcoma by regulating ferroptosis via the circFAM120B/miR-330-3p/PRKDC axis.
STAT3 inhibition ameliorates cognitive dysfunction in type 2 diabetes mellitus by modulating astrocytes via Nrf2 pathway activation.
Astragaloside IV mitigates myocardial ischemia/reperfusion injury by modulating the 14-3-3η/GPX4 axis, reducing mitochondrial dysfunction, ferroptosis, and apoptosis.
The Berberine Derivative BBR684 Inhibits VDAC Oligomerization to Suppress Ferroptosis in Acute Kidney Injury.
Hydroxyl radical from iridium(III)-based photosensitizer triggers PANoptosis and ferroptosis for hypoxia-tolerant photodynamic immunotherapy.
Synergistic induction of ferroptosis by paclitaxel and sunitinib is mediated through SLC7A11 in lung cancer.
Layered double hydroxide nanoplatform synergizes with sonodynamic therapy to induce dual activation of cuproptosis and ferroptosis for breast cancer treatment.
KLF16 transcriptionally activates HSPB1 to participate in the sorafenib resistance of hepatocellular carcinoma by driving ferroptosis resistance.
CDDO-Me alleviates doxorubicin/lapatinib-induced cardiotoxicity by activating the NRF2/GPX4 axis to inhibit oxidative stress and ferroptosis.
4-Octyl itaconate attenuates radiation-induced intestinal injury associated with ferroptosis inhibition and microbiota rebalance.
DPP4 suppresses pancreatic cancer growth by enhancing ferroptosis sensitivity through stabilization of ACSL4.
Pyrvinium pamoate inhibits the survival of intracellular Mycobacterium tuberculosis through suppression of macrophage ferroptosis.
PTK6 promotes ferroptosis resistance and CD8(+) T cell exhaustion in pancreatic tumors via reprogramming glucose and lipid metabolism.
MDM2-GPX4-ferroptosis regulatory axis exerts neurotoxic effects in intracerebral hemorrhage.
Sodium Houttuyfonate improves cognitive impairment in mice after chronic sleep deprivation by inhibiting microglial inflammation and ferroptosis.
Artemisinin Protects Diabetic Cardiomyopathy by Inhibiting Ferroptosis via Upregulating Nrf2/NQO1 and GPX4 Pathways.
Metformin alleviates presbycusis by activating the SIRT1/PINK1/GPX4 pathway in vitro and in vivo.
Mechanism of tectorigenin in promoting thermal burn wound healing via the Nrf2-mediated ferroptosis pathway: Integrated pharmacological and experimental study.
USP7 inhibitor P5091 enhances the antitumor efficacy of vemurafenib in BRAF(V600E)-mutant thyroid cancer via ferroptosis.
Chloride Channel-3 promotes ferroptosis of traumatic brain injury via SGK1/GSK3β pathway.
Dual-PPARα/δ agonist H11 alleviates tendinopathy via modulating the Nrf2/HO-1/GPX4 pathway.
TRIM37 regulates HMGB1 ubiquitination to inhibit ferroptosis in Schwann cells and alleviate peripheral nerve injury.
SS-31 improves post-cardiac arrest brain injury by inhibiting microglial ferroptosis and polarization.
Fisetin Ameliorates Vascular Calcification by Regulating HNRNPA1-Mediated Ferroptosis.
Shikonin improves intestinal barrier function through modulation of GPX4 expression in intestinal epithelial cells.
Eleutheroside E Attenuates Doxorubicin-Induced Cardiotoxicity by Suppressing Ferroptosis Through Activation of the Nrf2/SLC7A11/GPX4 Signaling Pathway.
Ferroptosis/Apoptosis Induction by an Iridium Complex Encapsulated in PLGA Nanoparticles Enhances Efficacy and Reduces Toxicity in Breast Cancer.
HucMSC-derived exosomes alleviate chemotherapy-induced premature ovarian insufficiency via SMURF1-mediated inhibition of ferroptosis in ovarian granulosa cells.
Chlorella-derived extracellular vesicle-based nanogels suppress cGAS-STING for treatment of radiation-induced lung injury.
Fuxin decoction regulates the Nrf2/SLC7A11/GPX4 pathway to ameliorate doxorubicin-induced ferroptosis in cardiomyocytes.
Dictamnine inhibited keratinocyte hyperproliferation and alleviated psoriasis-like dermatitis via blocking HIF1A-mediated ferroptotic pathway.
Rottlerin triggers dual degradation of SLC7A11 and GPX4 to drive ferroptosis and chemosensitization in hepatocellular carcinoma.
Solasonine inhibits NSCLC malignant progression by regulating SLC7A11 ubiquitination degradation and inducing ferroptosis.
Quercetin induces ferroptosis in ovarian cancer through regulating HSPB1/Notch1 pathway.
Qing-Chang-Hua-Shi granule ameliorates experimental colitis by modulating Lactobacillus gasseri-mediated ferroptosis metabolic pathway.
Inhibition of the RORC/GPX4 mediated ferroptosis regulatory axis suppresses tumor growth and alleviates enzalutamide resistance in prostate cancer.
Ferroptosis-related gene signature predicts prognosis and immunotherapy response in hepatocellular carcinoma: A multi-cohort retrospective study.
Long noncoding RNA PCAT7 confers radioresistance of esophageal squamous cell carcinoma by promoting GCLM-mediated anti-ferroptosis.
MEN1 Promotes Ferroptosis by Disrupting CD44 Alternative Splicing to Suppress Lung Cancer.
Intravesical instillation of pirfenidone/polydopamine nanoparticles for managing neurogenic bladder post-spinal cord injury by alleviating bladder inflammation and fibrosis.
Moscatilin alleviates severe acute pancreatitis by activating the NRF2/HO-1 pathway to inhibit ferroptosis.
Celastrol mitigates diabetic kidney disease by inhibiting ferroptosis via the SIRT1/NRF2/GPX4 pathway.
Erk5-mediated microglial ferroptosis drives ischemic white matter damage via the Nfatc4-Clptm1l axis.
Dunaliella salina-Loaded Diosmetin Carriers Alleviate Oxidative Stress and Inflammation in Cisplatin-Induced Acute Kidney Injury via PI3K/AKT Pathway.
The role of GPD2 on ferroptosis in sepsis-induced acute lung injury.
Licochalcone D modulates macrophage ferroptosis via suppression of VPS4A-mediated lipophagy to alleviate MRSA pneumonia.
Modulation of Macrophage ferroptosis under the guide of infrared thermography promotes the healing of pressure injuries.
Heme oxygenase 1 (HO-1) is a drug target for reversing cisplatin resistance in non-small cell lung cancer.
Hsa-miR-526b-5p Regulates the Sensitivity of Colorectal Cancer to 5-Fluorouracil by Targeting TP53 in Organoid Models.
Soufeng Yuchuan formula alleviates asthma airway inflammation and suppresses the progression of asthma by inhibiting ferroptosis in airway epithelial cells.
Integrating TWAS, chemical-genomic networks, and experimental models: melatonin as a ferroptosis inhibitor in osteoarthritis therapy.
THRA Orchestrates Myocardial Protection Against Hypothyroidism-Induced Ferroptosis via the GATA4-GPX4 Transcriptional Cascade.
Overexpression of OTUD5 in IPSCs-derived extracellular vesicles promotes angiogenesis after myocardial infarction by inhibiting endothelial cell ferroptosis.
Antimony Exposure Promotes Periodontitis by Activating Ferroptosis Pathway.
AGEs promote the metastasis of colorectal cancer cells via centrosome amplification by KLF5-CEP57L1 axis.
Smart responsive injectable hydrogel loaded with icariin inhibits ferroptosis and promotes nucleus pulposus repair in intervertebral disc degeneration.
Herbacetin alleviates Parkinson's disease by inhibiting ferroptosis in PC12 cells through the Nrf2/GPX4 pathway.
Lipid Droplets-Targeted Thermally Activated Delayed Fluorescence Photosensitizer for Photodynamic Therapy-Mediated Ferroptosis: a New Strategy for Tumor Radiosensitization.
A Functional Nanocomposite Tri-Activates Cuproptosis, Ferroptosis, and Mitophagy Death Pathway to Oppose Malignancies.
Melatonin counteracts Iodoacetic acid induced ferroptosis by regulating Nrf2 in porcine oocytes.
Ir(III) Complexes Convert Cold to Hot Tumors via Ferroptosis/Necroptosis-Driven Immunogenic Cell Death and Photosensitized CD47 Downregulation.
HSP70 Interactome-Mediated Proteolysis Targeting Chimera (HSP70-PROTAC) for Ferroptosis-Driven Cancer Treatment.
USP36 inhibits ferroptosis of melanoma cells by stabilizing APEX1.
Chemical induction of ferroptosis through GPX4 inhibition: Rational design of triazole-benzoxazine hybrids for melanoma therapy.
Combining network pharmacology and experimental validation to demonstrate that salidroside alleviates acute lung injury by inhibiting ferroptosis via the MAPK/GPX4 pathway.
Integrative metabolomic and single-cell transcriptomic analysis of recurrent condyloma acuminatum in humans.
miR-320a enhances radiosensitivity in non-small cell lung cancer by targeting RAD51 and modulating ferroptosis via GPX4.
Hydroxytyrosol Prevents Metabolic-Associated Steatohepatitis by Inhibiting SOCS2-Mediated Ferroptosis in High-Fat Diet Mice.
Sinensetin attenuates post-stroke depression via dual modulation of TLR4/NF-κB-NRF2/GPX4 pathways.
Expression patterns of glutathione peroxidases family members during tooth development.
Synergistic microenvironment therapy: a dual-function nanogel of supramolecular collagen ll-mimetic matrix and antioxidant MXene for attenuating intervertebral disc degeneration.
Saposhnikovia divaricata Inhibits Inflammation, Oxidative Stress, and Ferroptosis to Alleviate DSS-Induced Ulcerative Colitis.
SREBP1 knockdown triggers ferroptosis by suppressing the Nrf2-XCT/GPX4 axis in ovarian cancer.
CircRNA-TMEM71 Inhibits Human Aortic Smooth Muscle Cell Ferroptosis and Prevents Aortic Dissection Formation Through IGF2BP3-Mediated Stability of FSP1.
LBPs NPs suppress breast cancer progression by inhibiting YAP1 expression to induce ferroptosis and alter energy metabolism.
Akkermansia muciniphila affects colitis by inhibiting ferroptosis signaling pathway.
Integrated multi-omics analysis reveals GPD1L-mediated dysregulation of glycerophospholipid metabolism facilitates the progression of lung adenocarcinoma.
An intrabody targeting PHD2 protects mice against acetaminophen-induced liver injury by attenuating ferroptosis.
Bromodomain-containing protein 4 knockdown promotes neuronal ferroptosis in a mouse model of subarachnoid hemorrhage.
Multi-omics unravels multiple pharmacological actions in a murine model of infantile hemangioma receiving oxymatrine therapy.
Qigui didang decoction alleviates renal injury in a diabetic kidney disease model with metabolic memory features: association with ferroptosis and the SIRT1/Nrf2 pathway.
Ginkgolic acid targets HSPA8 to trigger ferroptosis in hepatocellular carcinoma via chaperone-mediated autophagy-dependent GPX4 degradation.
Low, plasma level‑informed native curcumin concentrations fail to induce cell death in human lung and colorectal cancer cells.
lncRNA MALAT1-mediated regulation of cholesterol-oxidative stress-iron metabolic dysregulation by paeoniflorin in osteoarthritic chondrocytes.
Endogenous H₂S promotes HSPA8 sulfhydration to downregulate HIF1α and prevent ferroptosis in septic myocardial injury.
EP300 attenuates ferroptosis and stimulates proliferation, migration, and fibrosis of keloid fibroblasts via YY1/GPX4 axis.
Comparative effects of dietary resveratrol and pterostilbene on meat quality, muscle antioxidant capacity, and muscle fiber composition in finishing pigs.
Xin Jia congrong tusizi decoction reverses ferroptosis in granulosa cells to rescue ovarian function decline via p53/Nrf2/SLC7A11/GPX4 signaling pathway.
SIRT7 facilitates ferroptosis resistance of melanocytes via activating the SMAD3-ATF3-GPX4 signaling pathway in vitiligo.
Electroacupuncture regulates neuronal ferroptosis and ferritinophagy through lysosomal-mediated TFEB activation in cerebral ischemia-reperfusion.
Application of a novel myristoylproteomics approach identifies GLIPR2 as a key pro-ferroptotic substrate in non-small cell lung cancer.
Injectable Zn(2+)-Driven carrier-free hydrogel via self-assembly of natural small molecules for liver fibrosis therapy through concurrent autophagy activation and ferroptosis inhibition.
Puerarin promotes nerve regeneration and functional recovery after peripheral nerve injury by inhibiting ACSL4-dependent ferroptosis.
Riboflavin metabolism shapes FSP1-driven ferroptosis resistance.
Nanomagnetic Hyperthermia Sensitizes Gemcitabine Chemosensitivity in Pancreatic Cancer by Inhibiting HSPB1 to Amplify ACSL4-Mediated Ferroptosis.
The ovarian tumor domain-containing protein 4 (OTUD4)-targeted ferroptosis inhibitor Maclekarpine E attenuates ulcerative colitis.
Resveratrol dual efficacy in high-altitude hypoxia and NAFLD: inhibits ferroptosis by modulating key proteins, including HIF-1α, ACSL4, and TfR1.
Apigenin-5-O-glucoside alleviates hepatic fibrosis through NOX4-mediated ferroptosis in zebrafish.
TrxR2 Lactylation Facilitates Mitochondrial Protection and Endothelial Ferroptosis Resistance in Diabetic Cardiomyopathy.
Remimazolam Ameliorates Autistic-Like Behaviors via Suppression of Ferroptosis in VTA Dopaminergic Neurons in a Mouse Model of ASD.
Inhibition of Calcium-Dependent Lipid Droplets Relocation of ACSL4-PKCβ-ALOX15 Complex Alleviates Ferroptosis and Acute Pancreatitis.
TRIM21 Alleviates Alcoholic Liver Fibrosis by Inhibiting Ferroptosis Through Regulation of IDO1 Ubiquitination.
Ferroptosis-STING co-activation drives GzmB(+)CD38(+)CD8(+) T-cell expansion to overcome lymphoma immunosuppression.
OLFM4 mediating ischemia/reperfusion-induced kidney injury by regulating renal tubular epithelial cells ferroptosis via GPX4.
PDK4 acts via hippo signaling to inhibit ferroptosis and reduce gemcitabine sensitivity in pancreatic cancer.
Enalaprilat reverses neutrophil polarization imbalance via targeting taurine-STING axis for treatment of diabetic wounds.
Multi-Ion Channel Nanomedicines Targeting Zinc Transporter 1/ATPase Copper Transporters Disrupt Copper/Iron Homeostasis to Enhance Tumor Immunotherapy.
Gallic acid: A promising anti-non-small cell lung cancer compound targeting early growth response protein-1 for apoptosis and ferroptosis.
Aberrant expression of TRIM26 suppresses ferroptosis through regulating GPX4 protein stability in colorectal cancer.
Molecular mechanism of testicular oxidative stress-induced ferroptosis in Leydig cells caused by cryptorchidism in yak.
Non-steroidal mineralocorticoid receptor antagonist finerenone ameliorates diabetic nephropathy via suppressing SLC7A11-mediated ferroptosis.
Kaempferol protects melanocytes from ferroptosis by modulating the NF-κB/PTGS2 signaling axis in vitiligo.
Saikosaponin D Alleviates Liver Ischemia-Reperfusion Injury by Inhibiting Mitophagy-Associated Ferroptosis via the STAT3/PINK1 Pathway.
Ferrostatin-1 attenuates sepsis-induced lung injury by inhibiting ferroptosis via activation of the SLC7A11/GSH/GPX4 signaling pathway.
EGF-Upregulated lncRNA ESSENCE Promotes Colorectal Cancer Growth through Stabilizing CAD and Ferroptosis Defense.
H2S inhibits high glucose-induced osteoblast injury by inhibiting ferroptosis in diabetic osteoporosis in vitro.
The Combination of Celastrol and Curcumin Enhances the Antitumor Effect in Nasopharyngeal Carcinoma by Inducing Ferroptosis.
Targeting p97/Valosin-Containing Protein Promotes Hepatic Stellate Cell Senescence and Mitigates Liver Fibrosis.
TRIM32 promotes neuronal ferroptosis by enhancing K63-linked ubiquitination and subsequent p62-selective autophagic degradation of GPX4.
Ferroptosis-Resistant Adipocytes Drive Keloid Pathogenesis via GPX4-Mediated Adipocyte-Mesenchymal Transition and Iron-Cystine Metabolic Communication.
HMGB1 Exacerbates Intestinal Barrier Damage by Inducing Ferroptosis Through the TLR4/NF-κB/GPX4 Pathway in Ulcerative Colitis.
Downregulation of NCOA4 expression indicates poor prognosis and promotes the progression of cholangiocarcinoma.
Silencing NRF2 enhances arsenic trioxide-induced ferroptosis in hepatocellular carcinoma cells.
Dapagliflozin inhibits ferroptosis to improve chronic heart failure by regulating Nrf2/HO-1/GPX4 signaling pathway.
Self-Assembled Carrier Free Oligomeric Proanthocyanidin/Tetrandrine Nanoparticles Ameliorate Osteoarthritis via Anti-Inflammatory and Anti-Ferroptotic Pathways.
MXene-Mediated Nanocarrier Delivery Enhances the Chondroprotective Effects of Quercetin in Experimental Osteoarthritis.
Exosomes Derived From Human Mesenchymal Stem Cells Mitigate Follicular Interstitial Cell Ferroptosis via the miR-26a-5p/PTEN/GPX4 Axis in Rats with Chemotherapy-Induced Premature Ovarian Insufficiency.
The Protective Role of DDIT4 in Helicobacter pylori-induced Gastric Metaplasia Through Metabolic Regulation of Ferroptosis.
Wedelolactone Ameliorates Ischemic Stroke by Inhibiting Oxidative Damage and Ferroptosis via HIF-1α/SLC7A11/GPX4 Signaling.
Translocator protein deficiency blocks the ferroptosis of malignant peripheral nerve sheath tumors through glutathione peroxidase 4.
Exploring the Kidney-Brain Crosstalk: Biomarkers for Early Detection of Kidney Injury-Related Alzheimer's Disease.
Astragaloside IV Alleviates Osteoarthritis by Inhibiting Chondrocyte Ferroptosis via the p53/SLC7A11/GPX4 Axis.
Astragaloside IV Attenuates Chronic Prostatitis by Activating Keap1/Nrf2/HO-1 Pathway: Suppressing Ferroptosis and Enhancing Antioxidant Defense.
Ferroptosis-related genes as prognostic markers for survival and immunotherapy in triple-negative breast cancer: analysis of public databases and a single institution.
Resveratrol Induces Oxidative Stress and Downregulates GPX4 and xCT to Activate the Ferroptosis Pathway for Anti-Bladder Cancer Organoids.
Ursolic Acid induces ferroptosis by affecting redox balance and FADS2-mediated unsaturated fatty acid synthesis in Non-Small Cell Lung Cancer.
Farrerol inhibits ferroptosis and protects against LPS-induced acute lung injury by targeting the RUNX1/SLC7A11 axis.
Radiation-induced eCIRP causes macrophage phagocytic dysfunction via mitochondrial impairment and ferroptosis.
Integrated network pharmacology and experimental verification to reveal the mechanisms of curcumin in the treatment of colorectal cancer.
Integrating network analysis and experimental validation to reveal the ferroptosis-associated mechanism of acteoside in the treatment of diabetic nephropathy.
Machine learning integration with multi-omics data constructs a robust prognostic model and identifies PTGES3 as a therapeutic target for precision oncology in lung adenocarcinoma.
Sarsasapogenin protects hair cells from cisplatin-induced ototoxicity by attenuating apoptosis and ferroptosis via alleviating oxidative stress.
Synergistic effect of regorafenib with aminoglycosides in ferroptosis-mediated liver injury.
Licochalcone D mitigates intracerebral hemorrhage-induced ferroptosis of neurons through COX2 inhibition.
Stimulation of regulatory dendritic cells suppresses cytotoxic T cell function and alleviates DEN-induced liver injury, fibrosis and hepatocellular carcinoma.
CircASH1L inhibits ferroptosis and enhances cisplatin resistance by sponging miR-515-5p to regulate cell cycle-related CDCA7/RRM2 in ovarian cancer cells.
Pachymic acid alleviates metabolic dysfunction-associated steatotic liver disease by inhibiting ferroptosis through PPARα.
Pan-cancer analysis reveals MTTP as a prognostic and immunotherapeutic biomarker in human tumors.
Asperosaponin VI suppresses ferroptosis in chondrocytes and ameliorates osteoarthritis by modulating the Nrf2/GPX4/HO-1 signaling pathway.
Semaglutide attenuates myocardial ischemia-reperfusion injury by inhibiting ferroptosis of cardiomyocytes via activation of PKC-S100A9 axis.
Ferulic acid inhibits ox-LDL-induced ferroptosis and apoptosis in RAW 264.7 cells via the HIF-1 signaling pathway.
Berbamine attenuates hind limb ischemia-reperfusion injury by eliminating lipid ROS and inhibiting p65 nuclear translocation.
Gallic acid protects intervertebral disc cells from ferroptosis and alleviates intervertebral disc degeneration by regulating key factors of oxidative stress.
Bioactive natural alkaloid 6-Methoxydihydrosanguinarine exerts anti-tumor effects in hepatocellular carcinoma cells via ferroptosis.
The contrasting regulatory effects of valproic acid on ferroptosis and disulfidptosis in hepatocellular carcinoma.
Oxidative stress-mediated PANoptosis and ferroptosis: Exploration of multimodal cell death triggered by an AIE-active nano-photosensitizer via photodynamic therapy.
Ferroptosis's Master Switch GPX4 emerges as universal biomarker for precision immunotherapy: a pan-cancer study with in vitro experiments validation.
Securinine, a novel alkaloid, regulates cell cycle and EMT in gastric cancer by inducing iron-dependent cell death.
Gypensapogenin I alleviates PANoptosis, ferroptosis, and oxidative stress in myocardial ischemic-reperfusion injury by targeting the NOX2/AMPK pathway.
Methylglyoxal induces oxidative stress and ferroptosis of renal tubular epithelial cells in acute and chronic kidney injury mice.
Jianpi Yangzheng Xiaozheng granule induced ferroptosis to suppress gastric cancer progression through reprogramming lipid metabolism via SCD1/Wnt/β-catenin axis.
Hsp90 C-terminal domain inhibition enhances ferroptosis by disrupting GPX4-VDAC1 interaction to increase HMOX1 release from oligomerized VDAC1 channels.
Multi-omics analysis reveals the mechanism of action of Atractylodin against depression.
The role and mechanism of PGC-1α in oxLDL-induced ferroptosis of vascular endothelial cells.
Oxidative stress activates YAP/TEAD1/NCOA4 axis to promote ferroptosis of endplate chondrocytes and aggravate intervertebral disc degeneration.
Microplastic exposure induces preeclampsia-like symptoms via HIF-1α/TFRC-mediated ferroptosis in placental trophoblast cells.
Changes of N6-methyladenosine and ferroptosis in cadmium-induced reproductive toxicity of male mice fed a high fat and high sugar diet.
Gallium maltolate and cisplatin co-treatment effectively targets triple-negative breast cancer in spheroid and mouse models.
Introduced paeoniflorin reduces the main toxicity induced by diosbulbin B, the major toxic compound of Dioscorea bulbifera L.: involved inhibiting inflammation and ferroptosis.
Complexin 2 contributes to the protective effect of NAD(+) on neuronal survival following neonatal hypoxia-ischemia.
Exploring the potential mechanism of atorvastatin in regulating ferroptosis as a treatment for heart failure based on network pharmacology.
Brucine Inhibits Gastric Cancer via Activation of Ferroptosis Through Regulating the NF-κB Signaling Pathway.
Embelin Mitigates the Impact of Perinatal Inflammation on Neuron Development by Inhibiting 5-Lipoxygenase-Mediated Ferroptosis.
Proanthocyanidin B2 Alleviates Cuprizone-Induced Demyelination by Regulating the Astrocytic xCT/GSH/GPX4 Axis.
PTBP1 acts as a tumor suppressor in glioma by promoting HMOX1-dependent ferroptosis.
Intratumor microbiome-derived butyrate enhances progesterone sensitivity by inducing ferroptosis in endometrial cancer.
Atp7a deficiency induces axonal and myelin developmental defects in zebrafish via ferroptosis.
LncRNA 91234.1 targets PRMT1/ASCL4/GPX4 axis to regulate formaldehyde-induced cardiomyocyte ferroptosis and congenital heart disease.
Placental Ferroptosis May Be Involved in Prenatal Arsenic Exposure Induced Cognitive Impairment in Offspring.
Unraveling the molecular mechanisms of paraquat toxicity: The interplay of ATF4, ferroptosis, and endoplasmic reticulum stress.
Activation of Rab7-mediated lipophagy is required for triptolide to induce ferroptosis in hepatic cells.
Discovery of 8-hydroxy-tetrahydroquinoline ferroptosis inhibitors for the treatment of acute kidney injury.
An SPR-based active ingredient recognition strategy for identifying PLK1-targeting withanolides as natural ferroptosis inducers.
Taraxerol induces ferroptosis in breast cancer by targeting Nrf2 transcriptional activity to promote MIB2-mediated GPX4 ubiquitination.
Formononetin enhances cisplatin chemotherapy sensitivity in osteosarcoma by inducing ferroptosis and reconstructing the immune microenvironment.
USP10 Inhibits Ferroptosis via Deubiquinating POLR2A in Head and Neck Squamous Cell Carcinoma.
TMAO regulates OTUB1-mediated SLC7A11 stability to promote NAFLD progression.
FGF5 alleviates ferroptosis in renal tubular epithelial cells by inducing mitophagy under in vitro ischemia-reperfusion-like injury.
Crotonoside induces ferroptosis and mitochondrial dysfunction in AML.
Baicalein suppresses the malignant progression of acute myeloid leukemia via ROS-dependent metabolic reprogramming: Mechanisms of differentiation induction and ferroptosis activation.
Coelenterazine alleviates sepsis-associated acute kidney injury by inhibiting ferroptosis via the USP14-NCOA4 pathway.
Eucommia ulmoides (Duzhong) extract alleviates cerebral stroke by inhibiting ferroptosis-related gene DNA Damage-Inducible Transcript 4 (DDIT4) expression.
BRD-K20733377 inhibits ferroptosis and alleviates intervertebral disc degeneration via the STAT3/NFKB1 axis: a multiapproach study.
Zingerone treats postmenopausal osteoporosis via increased ferroptosis sensitivity by p53-mediated regulation of SAT1 and GPX4 expression.
Protecting the brain from stroke: Huoxue Rongluo formula (HXRLF) targets ferroptosis for neuroprotection.
Dovitinib Ameliorates Inflammation-Related Diseases by Inhibiting Necroptosis and Ferroptosis.
Protective Effect of Hepcidin on Sepsis-Associated Acute Kidney Injury via Activating the Nrf2/GPX4 Signaling Pathway.
Farrerol ameliorates diabetic cardiomyopathy by inhibiting ferroptosis via miR-29b-3p/SIRT1 signaling pathway in endothelial cells.
Entospletinib alleviates acute liver injury and acute kidney injury by inhibiting ferroptosis.
Osteoblast ferroptosis driven by iron overload: Implications for osteoporosis pathogenesis and FTH1/GPX4-targeted therapy.
Lead binds HIF-1α contributing to depression-like behaviour through modulating mitochondria-associated astrocyte ferroptosis.
Zearalenone induces intestinal damage and flora disturbance in rats by triggering ferroptosis via the system Xc(-)-GSH-GPX4 signaling pathway.
Houttuynia cordata Thunb-derived extracellular vesicle-like particles alleviate ischemic brain injury by miR159a targeting ACSL4 to suppress ferroptosis.
Glycyrrhizic Acid Ameliorates LPS-Induced WI-38 Cell Inflammation, Oxidative Stress, and Ferroptosis via Targeting METTL14 in Infantile Pneumonia.
4-Octyl Itaconate Attenuates Postmenopausal Osteoporosis by Inhibiting Ferroptosis and Enhancing Osteogenesis via the Nrf2 Pathway.
Reprogramming Iron Metabolism via the RIG-I/c-Myc/FTH Axis Mitigates Renal Ischemia-Reperfusion Injury.
Ferritinophagy Is Involved in the Advanced Glycation End Products-Induced Ferroptosis of Vascular Endothelial Cells in Diabetes Mellitus.
Centipede Polypeptide Affects the Inflammatory Reaction and Ferroptosis of Liver Cancer Cells Through the p53/TRAIL Pathway.
Berberine inhibits high glucose-induced ferroptosis in retinal vascular endothelial cells: Mechanism and implications.
3D printed GelMA/HAMA based mechanical microenvironment boosted PDAC chemoresistance via NRF2-repressed ferroptosis.
RTA-408 overcomes cisplatin-resistant lung cancer by inhibiting WWP1-mediated NCOA4 ubiquitination to induce ferritinophagy and ferroptosis.
Panx3 mediates ferroptosis via the AKT/mTOR signaling pathway in oral squamous cell carcinoma.
PIEZO1-GPX4 Axis Mediates Mechanical Stress-Induced Vertebral Growth Plate Dysplasia via Ferroptosis Activation.
Adaptive Antioxidant Nanomedicines Inhibit Ferroptosis in Renal Tubular Epithelial Cells to Alleviate Diabetic Kidney Disease.
SLC25A10 promotes cisplatin resistance by inhibiting ferroptosis in cervical cancer.
Ferroptosis-Enhanced Radiopharmaceutical Therapy via a Manganese-Based Nanoplatform.
Microwave dynamic therapy induces ferroptosis in colorectal cancer by targeting PTK2B to regulate STAT3-mediated GPX4 expression.
Lipid peroxidation and type I interferon coupling fuels pathogenic macrophage activation causing tuberculosis susceptibility.
Fe-doped phase-transition nanodroplets for synergistic photothermal and starvation-enhanced ferroptosis in cancer therapy.
Exocarpium Citri Grandis ameliorates alcoholic liver disease by modulation of hepatic lipid metabolism and iron homeostasis.
Integrated Multiomic Analysis Reveals the Therapeutic Potential of Danhong Injection in Mitigating Radiation-Induced Heart Disease by Modulating Ferroptosis.
Liraglutide attenuates doxorubicin-induced cardiomyocyte ferroptosis via DHHC7-mediated STAT3 palmitoylation.
Human amniotic mesenchymal stem cell-derived exosome inhibits ferroptosis through the suppression of JNK/MAPK-mediated EGR1 expression in spontaneous intracerebral hemorrhage.
P2X7R activation promotes ferroptosis in dopaminergic neurons via NF-κB signaling pathway in vitro and in vivo models of MPP(+)/MPTP-induced Parkinson's disease.
Analysis of the Correlation Between Depression-like Behaviors and Lipid Peroxidation in the Prefrontal Cortex of Mice: The Impact of Early Life Stress.
Ginsenoside Rb3 modulates gut microbiota to alleviate cerebral inflammation and ferroptosis via the NLRP3/NF-κB/GPX4 pathway in rats with cerebral ischemia/reperfusion injury.
SAP30BP aggravates mitochondrial-related ferroptosis in diabetic cardiomyopathy by regulating MFN2-ACSL4 axis.
FASN inhibits ferroptosis in breast cancer via USP5 palmitoylation-dependent regulation of GPX4 deubiquitination.
PK11007 Covalently Inhibits Thioredoxin Reductase 1 to Induce Oxidative Stress and Autophagy Impairment in NSCLC Cells.
Blood flow restriction training attenuates stroke-induced hippocampal ferroptosis, synaptic damage, and cognitive impairment via upregulating SIRT1 pathway.
Mechanistic insights into the renoprotective effects of artesunate in cisplatin-induced acute kidney injury.
MINPP1 promotes ferroptosis in HBV-related hepatocellular carcinoma by regulating CTSB K33-linked deubiquitination via ZRANB1.
METTL3-mediated m6A modification promotes ferroptosis in adenomyosis through GPX4 in a YTHDF1-dependent manner.
Targeting SIRT3 to regulate mitophagy-dependent ferroptosis for preventing glucocorticoid-induced osteoporosis.
TRIM39-mediated deubiquitination upregulates RNF168 to evade autophagy-ferroptosis in triple-negative breast cancer.
Inhibition of ferroptosis by serine protease inhibitor attenuates acute respiratory distress syndrome.
Targeting ZNRF2-mediated SLC3A2 plasma membrane translocation enhances ferroptosis in lung adenocarcinoma.
ML385 increases ferroptosis via inhibiting Nrf2/HO-1 pathway to enhances the sensitivity of MCF-7 TAMR to tamoxifen.
NDUFA8 promotes cell viability and inhibits ferroptosis and cisplatin sensitivity by stabilizing Fe-S clusters in cervical cancer.
Quercetin Targets HSP90α and Regulates Keap1/Nrf2 Pathway to Inhibit Crosstalk between Apoptosis and Ferroptosis in Oxidatively Stressed Neurons.
Jujuboside B Induces Ferroptosis and Overcomes Radioresistance Through the PPARγ-ATF3-Gpx4 Signaling Pathway in Non-Small Cell Lung Cancer.
Structural characterization and functional role of SLC7A6 in GSSG transport and Ferroptosis regulation.
ARID1A loss enhances sensitivity to c-MET inhibition by dual targeting of GPX4 and iron homeostasis, inducing ferroptosis.
Silymarin ameliorates diet-induced gallstone formation by regulating gut microbiota-derived GCDCA to suppress ferroptosis-ROS-NFκB signaling pathway.
Deferoxamine attenuates sepsis-induced liver injury by suppressing ferroptosis.
SFTSV induces liver ferroptosis through m6A-related ferritinophagy.
Mechanism and marker of voriconazole-induced liver injury: insights from a quantitative systems toxicology approach.
CX-5461 inhibits cell proliferation and induces ferroptosis of colorectal cancer cells by inactivating Nrf2 pathway.
Optimized Monothiol Thioredoxin Derivative (ORP100S) Protects In Vitro and In Vivo from Radiation and Chemotoxicity Without Promoting Tumor Proliferation.
Downregulation of acetyl-CoA carboxylase induces ferroptosis and inhibits tumor growth in oral squamous cell carcinoma.
RRM2 contributes to pathogenic phenotype of fibroblast-like synoviocytes by activating NF-κB signaling and inhibiting ferroptosis in rheumatoid arthritis.
Iron addicted colorectal cancers exploit Heme-Complex II axis to resist oxidative cell death.
Palmitic Acid Induces Ferroptosis in Retinal Microvascular Endothelial Cells by Palmitoylation of Keap1 to Affect Diabetic Retinopathy.
Taoren Honghua Jian improves ferroptosis-mediated myocardial damage following myocardial infarction via Nrf2-dependent enhancement of GPX4/FSP1.
PTBP1 functions as a suppressor of ferroptosis in endometrial carcinoma cells by stabilizing SLC7A11 mRNA.
Ferroptosis mediated by ferritinophagy is involved in liver injury caused by sepsis.
Identification of Potential Key Ferroptosis-Related Genes in EV71-Infected Cells Through Bioinformatics Analysis and Experimental Study.
Scutellarin triggers ferroptosis in ovarian cancer cells via inhibiting AKT/mTOR and JAK2/STAT3 pathways.
Self-assembled phenylboronic acid nanomedicine targets sialic acid to synergistically activate ferroptosis via RRM1 suppression and GPX4 Inhibition for precision colon cancer therapy.
Breviscapine targets EGFR and SRC to abrogate diabetes-driven GPX4 lactylation and ferroptosis resistance in gastric cancer.
Verbascoside (VB) Inhibits Ischemic Stroke Progression via Suppression of Cell Damage and Ferroptosis By Targeting LCN2/ALOX5/SLC7A11/GPX4 Expression.
Targeting the ROS-ferroptosis-inflammation cycle with a nanozyme-functionalized hydrogel for intervertebral disc repair.
Targeting cancer stem-like cells via cholesterol modulation and ferroptosis induction using a multifunctional nanoplatform to overcome drug resistance.
WTAP regulates NCOA4-mediated ferroptosis via a YTHDF2-dependent mechanism in preeclampsia.
FGF21-engineered ADSCs promote diabetic wound healing by mitigating ferroptosis and oxidative stress via the SIRT1/NRF2/GPX4 signaling pathway.
Molecular regulatory mechanism of the SIRT2/NF-κB p65 signaling pathway in ferroptosis-promoted spinal cord injury repair.
NCOA4-mediated ferroptosis conducive to EMT inhibition in colorectal cancer cells was achieved through the PI3K/AKT/mTOR pathway.
Dietary supplementation of Chlorella pyrenoidosa attenuated non-alcoholic fatty liver disease via the NF-κB/ferroptosis axis.
NRG1/PDGFC loop between fibroblasts and cancer cells drives paclitaxel resistance via ferroptosis suppression in breast cancer.
CLDND1 as a prognostic ferroptosis-associated biomarker in oral squamous cell carcinoma.
Formoterol, a clinically approved drug, inhibits ferroptosis by suppressing lipid peroxidation and attenuates APAP-induced acute liver injury.
Identification and Validation of Potential Immune-Related Genes for Endometriosis.
FOXO3a-BAP1 axis regulates neuronal ferroptosis in early brain injury after subarachnoid hemorrhage.
Brigatinib activates inflammasomes: Implication for immune-related adverse events.
Sirt1 overexpression inhibits chondrocyte ferroptosis via Ftl deacetylation to suppress the development of osteoarthritis.
The ferroptosis of sertoli cells inducing blood-testis barrier damage is produced by oxidative stress in cryptorchidism.
Adipose stem cells ameliorate erectile dysfunction in diabetes mellitus rats by attenuating ferroptosis through NRP1 with SLC7A11 interaction.
Pad2 deletion induces anxiety‑like behaviors and memory deficits in mice.
Neuroprotective effects of hirudin against cerebral ischemia-reperfusion injury via inhibition of CCL2-mediated ferroptosis and inflammatory pathways.
Polyphyllin VII promotes hepatic stellate cell ferroptosis via the HIC1/CX3CL1/GPX4 axis.
Resveratrol Promotes Wound Healing by Enhancing Angiogenesis via Inhibition of Ferroptosis.
Human antigen R -mediated autophagy-related gene 3 methylation enhances autophagy-driven ferroptosis in Crohn's disease colitis.
OTULIN orchestrates NCOA4-FTH1 complex to alleviate APAP-induced hepatocyte Ferroptosis.
Extracellular vesicles derived from bone marrow mesenchymal stem cells regulate SREBF2/HMGB1 axis by transporting miR-378a-3p to inhibit ferroptosis in intestinal ischemia-reperfusion injury.
Shenfu injection ameliorates hepatic ischemia-reperfusion injury through induction of ferroptosis via JAK2/STAT3 pathway.
Inhibition of Cyclooxygenase-2 Upregulates the Nuclear Factor Erythroid 2-related Factor 2 Signaling Pathway to Mitigate Hepatocyte Ferroptosis in Chronic Liver Injury.
OTUD4 inhibits ferroptosis by stabilizing GPX4 and suppressing autophagic degradation to promote tumor progression.
MSC-derived exosomal miR-125b-5p suppressed retinal microvascular endothelial cell ferroptosis in diabetic retinopathy.
Melatonin inhibits salivary gland epithelial cell ferroptosis via the NRF2/HO-1/GPX4 signaling pathway in primary Sjögren's syndrome.
Astilbin Alleviates IL-17-Induced Hyperproliferation and Inflammation in HaCaT Cells via Inhibiting Ferroptosis Through the cGAS-STING Pathway.
Homocysteine induces endometrial ferroptosis via MAPK pathway in recurrent pregnancy loss.
Arginine Deprivation Induces Quiescence and Confers Vulnerability to Ferroptosis in Colorectal Cancer.
Study on Cellular Mechanism of Improving Inflammatory Effect of Gastrodin.
NCOA5 induces sorafenib resistance in hepatocellular carcinoma by inhibiting ferroptosis.
Cohabitation facilitates microbiome shifts that promote isoflavone transformation to ameliorate liver injury.
Platelet-Rich Plasma-Derived Exosome-Encapsulated Hydrogels Accelerate Diabetic Wound Healing by Inhibiting Fibroblast Ferroptosis.
TRIM21 knockdown alleviates hemorrhage induced hepatic ischemia reperfusion injury by suppressing ferroptosis-induced NETs.
TNF-α inhibits Epstein Barr virus reactivation through the GPX4 mediated glutathione pathway.
The anti-Alzheimer's disease effects of ganoderic acid A by inhibiting ferroptosis-lipid peroxidation via activation of the NRF2/SLC7A11/GPX4 signaling pathway.
LncRNA TCONS_00067339 as a key regulatory factor inducing decreased cell viability and ferroptosis in neonatal hypoxic-ischemic brain damage.
Benzyl butyl phthalate promotes ferroptosis in Sertoli cells via disrupting ceruloplasmin-mediated iron balance.
Bergapten Ameliorates Renal Fibrosis by Inhibiting Ferroptosis.
Integrative bioinformatics analysis reveals CGAS as a ferroptosis-related signature gene in sepsis and screens the potential natural inhibitors of CGAS.
Inhibition of ferroptosis protects intrahepatic bile duct cells against ischemia-reperfusion and bile salt toxicity.
Repurposing alcohol-abuse drug disulfiram for the treatment of KSHV-infected primary effusion lymphoma by activating antiviral innate immunity.
Piceatannol upregulates USP14-mediated GPX4 deubiquitination to inhibit neuronal ferroptosis caused by cerebral ischemia-reperfusion in mice.
Exosome-Derived CDC42 From Hypoxia-Pretreated Neural Stem Cells Inhibits ACSL4-Related Ferroptosis to Alleviate Vascular Injury in Parkinson's Disease Mice Models.
p53 inhibits OTUD5 transcription to promote GPX4 degradation and induce ferroptosis in gastric cancer.
HMGB1 secretion by resveratrol in NSCLC: A pathway to ferroptosis-mediated platelet activation suppression.
The Lactate-Primed KAT8‒PCK2 Axis Exacerbates Hepatic Ferroptosis During Ischemia/Reperfusion Injury by Reprogramming OXSM-Dependent Mitochondrial Fatty Acid Synthesis.
HPV E6/E7-Induced Acetylation of a Peptide Encoded by a Long Non-Coding RNA Inhibits Ferroptosis to Promote the Malignancy of Cervical Cancer.
AC129507.1 is a ferroptosis-related target identified by a novel mitochondria-related lncRNA signature that is involved in the tumor immune microenvironment in gastric cancer.
Gallic acid alleviates ferroptosis by negatively regulating APOC3 and improves nerve function deficit caused by traumatic brain injury.
ALPK1 signaling pathway activation by HMGB1 drives microglial pyroptosis and ferroptosis and brain injury after acute ischemic stroke.
Ovarian aging-associated downregulation of GPX4 expression regulates ovarian follicular development by affecting granulosa cell functions and oocyte quality.
Edaravone dextranol alleviates ferroptosis, Cuproptosis, and blood-brain barrier damage after acute cerebral infarction.
Phenolics and Phenolic Glycosides from Wrightia pubescens and Their Hepatoprotective Activities.
Gancao Xiexin decoction attenuated experimental colitis through suppressing ACSL4-mediated ferroptosis.
USP5 Suppresses Ferroptosis in Bladder Cancer Through Stabilization of GPX4.
Increased melanin induces aberrant keratinocyte - melanocyte - basal - fibroblast cell communication and fibrogenesis by inducing iron overload and ferroptosis resistance in keloids.
Nrf2 ameliorates defective autophagic processes and thereby inhibits ferroptosis in acute pancreatitis by suppressing Beclin1-Slc7a11 complex formation.
Modulating HIF-1α/HIF-2α homeostasis with Shen-Qi-Huo-Xue formula alleviates tubular ferroptosis and epithelial-mesenchymal transition in diabetic kidney disease.
Vagus nerve stimulation alleviates myocardial injury following hepatic ischemia-reperfusion in rats by inhibiting ferroptosis via the activation of the SLC7A11/GPX4 axis.
Bisphenol F induces spermatogenic cell ferroptosis via FTO-mediated m6A regulation of FTH1.
Disorders of Iron Metabolism: A "Sharp Edge" of Deoxynivalenol-Induced Hepatotoxicity.
Exosomal miR-196a-5p Secreted by Bone Marrow Mesenchymal Stem Cells Inhibits Ferroptosis and Promotes Drug Resistance of Acute Myeloid Leukemia.
Silibinin alleviates acute liver failure by modulating AKT/GSK3β/Nrf2/GPX4 pathway.
Quercetin-loaded exosomes delivery system prevents myopia progression by targeting endoplasmic reticulum stress and ferroptosis in scleral fibroblasts.
Sorafenib-loaded metal-organic framework nanoparticles for anti-hepatocellular carcinoma effects through synergistically potentiating ferroptosis and remodeling tumor immune microenvironment.
Injectable deferoxamine-loaded microsphere hydrogels for inhibition of ferroptosis and promotion of third-degree burn wound healing.
Enhanced inhibition of neuronal ferroptosis and regulation of microglial polarization with multifunctional traditional Chinese medicine active ingredients-based selenium nanoparticles for treating spinal cord injury.
Novel pH-responsive lipid nanoparticles deliver UA-mediated mitophagy and ferroptosis for osteoarthritis treatment.
Bufotalin loaded biomimetic nanodrug for combined chemo/photodynamic therapy of cancer.
Optically controllable nanoregulators enable tumor-specific pro-ferroptosis lipometabolic reprogramming for in-situ adjuvant-free vaccination.
Nutrient deficiency-induced downregulation of SNX1 inhibits ferroptosis through PPARs-ACSL1/4 axis in colorectal cancer.
Antitumor/anti-inflammatory effects/tissue healing as an all-in-one therapeutic strategy for nasopharyngeal carcinoma.
Mechanistic evaluation of a traditional herbal decoction in attenuating hepatic fibrosis via Nrf2/GPX4 pathway activation and ferroptosis inhibition.
α9 Nicotinic Acetylcholine Receptor Promotes Tumor Proliferation and Suppresses Ferroptosis in Triple-Negative Breast Cancer.
Oligo-peptide I-C-F-6 mitigates polymicrobial sepsis-induced cardiac dysfunction in mice.
Sirtuin-3 activation by honokiol attenuated anesthesia/surgery-induced cognitive impairment and neuronal ferroptosis via inhibiting mitochondrial GPX4 acetylation.
African swine fever virus A151R downregulates cGAS-STING-mediated IFN-β production by promoting lipid peroxidation through ferritinophagy-induced ferroptosis.
Mitochondrial alanyl-tRNA synthetase 2 mediates histone lactylation to promote ferroptosis in intestinal ischemia-reperfusion injury.
Marsdenia tenacissima extract accelerates ferroptosis of osteosarcoma cells by upregulating HO-1 and activating mitophagy.
Network pharmacology analysis reveals that coumestrol targets ZYX to inhibit ferroptosis and alleviate acute pancreatitis.
CISD2 ameliorates heatstroke-associated early cognitive deficits by inhibiting ferroptosis and maintaining dendritic spine density in hippocampal neurons in mice.
Salidroside Exerts Neuroprotective Effects via Inhibiting Ferroptosis in Mice with Traumatic Brain Injury.
Roles of ACSL4/GPX4 and FSP1 in oxalate-induced acute kidney injury.
Targeting SIX2 as a novel sensitization strategy of sorafenib treatment on advanced hepatocellular carcinoma through modulating METTL9-SLC7A11 axis.
Dingzhen pills inhibit neuronal ferroptosis and neuroinflammation by inhibiting the cGAS-STING pathway for Parkinson's disease mice.
Protein Kinase D Knockdown Alleviates Vascular Calcification Through P53-SLC7A11 Axis-Mediated Ferroptosis.
Genome-guided discovery of coublibactins from Nocardia coubleae and their gallium complexes with potent antileukemic activity.
Integrating network analysis and experimental validation to reveal the ferroptosis-associated mechanism of velvet antler in the treatment of chronic atrophic gastritis.
Polyoxometalate-Containing Nanocomposite Hydrogels for Cascade-Catalytic and Photothermal Dually Enhanced Chemodynamic Therapy.
A Dual-Factor Scaffold for Spinal Cord Injury Repair Targeting Inflammation and Ferroptosis.
BTN3A2 interacted with MFGE8 to alleviate preeclampsia by promoting ferroptosis and inhibiting angiogenesis.
Ambient fine particulate matter induces cardiac fibrosis through triggering ferroptosis by heme degradation induced-iron overload.
Brassinin from Brassica campestris L. inhibits colorectal cancer by inducing p62/NRF2/GPX4-regulated ferroptosis.
Platelet-rich plasma inhibits ferroptosis and inflammation to alleviate frozen shoulder via activating the CST1/GPX4 signaling pathway.
Taurine Attenuates Neuronal Ferroptosis by CSF-Derived Exosomes of GABABR Encephalitis Through GABABR/NF2/P-YAP Pathway.
Carfilzomib promotes Iodine-125 seed radiation-induced apoptosis, paraptosis, and ferroptosis in esophageal squamous cell carcinoma by aggravating endoplasmic reticulum stress.
Lung microbiota metabolite L-malic acid attenuates the airway inflammation in asthma by inhibiting ferroptosis.
Identification of FADS2 as a Contributor of Ferroptosis Escape in Bladder Cancer.
Constitutive Hepatic mTORC1 Activation Aggravates Alcohol-Induced Liver Injury via Endoplasmic Reticulum Stress-Mediated Ferroptosis.
Identification of a new micropeptide altKLF4 derived from KLF4 that influences myeloma chemotherapeutic sensitivity.
p38γ modulates ferroptosis in brain injury caused by ethanol and cerebral ischemia/reperfusion by regulating the p53/SLC7A11 signaling pathway.
PP1A Modulates the Efficacy of Lenvatinib Plus ICIs Therapy by Inhibiting Ferroptosis in Hepatocellular Carcinoma.
Dermal papilla cells-conditioned medium attenuates oxidative stress-induced senescence via ferroptosis inhibition.
Quercetin nanoformulation-embedded hydrogel inhibits osteopontin mediated ferroptosis for intervertebral disc degeneration alleviation.
Design, synthesis, and biological evaluation of quinolinyl-ureido-phenyl-hydrazide derivatives and quinolinyl-hydrazide derivatives as anticancer agents targeting Nur77-mediated ferroptosis.
Nuclear receptor FXR inhibits ferroptosis to alleviate hepatic ischemia-reperfusion injury by targeting GPX4 in a mouse model.
NEFA Induces Ferroptosis in Transition Dairy Cattle Liver by Increasing Lipid Reactive Oxygen Species and Downregulating SLC7A11.
Transcription factor TCF3 promotes bladder cancer development via TMBIM6-Ca(2+)-dependent ferroptosis.
Soy Isoflavone Supplementation in Sow Diet Enhances Antioxidant Status and Promotes Intestinal Health of Newborn Piglets.
Cadmium Inhibits Proliferation of Human Bronchial Epithelial BEAS-2B Cells Through Inducing Ferroptosis via Targeted Regulation of the Nrf2/SLC7A11/GPX4 Pathway.
Large-scale RNA-Seq mining reveals ciclopirox olamine induces TDP-43 cryptic exons.
Ponicidin triggered ferroptosis in esophageal squamous cell carcinoma by suppressing the SLC7A11/Glutathione/GPX4 signalling axis.
Protocatechuic acid suppresses ferroptosis to protect against hypoxic-ischemic encephalopathy by targeting the HIF-1α/VEGFA axis.
Caffeic acid phenethyl ester protects renal tubular epithelial cells against ferroptosis in diabetic kidney disease via restoring PINK1-mediated mitophagy.
Gut microbiota-bile acid crosstalk contributes to calcium oxalate nephropathy through Hsp90α-mediated ferroptosis.
Large-sized polystyrene microplastics induce oxidative stress in AML12 cells.
Low doses of ozone alleviate cardiomyocyte ferroptosis induced by hypoxia-reoxygenation injury via the AMPK-mTOR pathway.
The SDF-1α/MTDH axis inhibits ferroptosis and promotes the formation of anti-VEGF-resistant choroidal neovascularization by facilitating the nuclear translocation of SREBP1.
S-COS-Se mitigates cadmium-induced oxidative stress, inflammation, and immunotoxicity by restoring immune balance and inhibiting mitochondria-pyroptosis crosstalk.
Integrative proteomics and metabolomics analyses reveals the regulation of autophagy and ferroptosis by RAB10 through Slc37a2/mTOR pathway in breast cancer.
Effects of solamargine in hepatic metastasis of colorectal cancer: induction of ferroptosis and elimination of cancer stem cells.
Microglial exosome TREM2 ameliorates ferroptosis and neuroinflammation in alzheimer's disease by activating the Wnt/β-catenin signaling.
Taurine Attenuates Disuse Muscle Atrophy Through Modulation of the xCT-GSH-GPX4 and AMPK-ACC-ACSL4 Pathways.
SETD1B promotes brain cell ferroptosis in ischemic stroke mice via increasing H3K4me3 enrichment on the Tfrc promoter.
Translational medicine research on the role of key gene network modulation mediated by procyanidin B2 in the precise diagnosis and treatment of multiple sclerosis.
A Self-Assembling Chimeric Peptide Gear-Set with "Three-in-One" Function for Precision Photodynamic Therapy.
MiR-125b-5p ameliorates ventilator-induced lung injury in rats by suppressing ferroptosis via the regulation of the Keap1/Nrf2/GPX4 signaling pathway.
cDTL contributes to breast cancer progression through regulating redox homeostasis via affecting the function of system xc().
Dehydrocostus lactone suppresses gastric cancer progression by targeting ACLY to inhibit fatty acid synthesis and autophagic flux.
Biomimetic Nanomotors for Deep Ischemia Penetration and Ferroptosis Inhibition in Neuroprotective Therapy of Ischemic Stroke.
Amelioration of arsenic-induced hepatic injury via sulfated glycosaminoglycan from swim bladder: Modulation of Nrf2 pathway and amino acid metabolism.
Leonurine restrains granulosa cell ferroptosis through SLC7A11/GPX4 axis to promote the treatment of polycystic ovary syndrome.
Ginsenoside Rb1 targets to HO-1 to improve sepsis by inhibiting ferroptosis.
Lipoxin A4 suppresses neutrophil extracellular traps formation through the FPR2-dependent regulation of METTL3 in ischemic stroke.
Disruption of Ferroptosis Inhibition and Immune Evasion with Tumor-Activatable Prodrug for Boosted Photodynamic/Chemotherapy Eradication of Drug-Resistant Tumors.
Quercetin inhibits hydrogen peroxide-induced cleavage of heat shock protein 90 to prevent glutathione peroxidase 4 degradation via chaperone-mediated autophagy.
Bardoxolone methyl triggers Ferroptosis in cardiomyocytes.
Precise Carrier-Free Pt(IV)-Nanobombs for Apoptosis/Ferroptosis Synergistic Tumor Therapy: A New Effective Method to Obtain Good Chemotherapy and Low Toxicity.
Melanin-Deferoxamine Nanoparticles Targeting Ferroptosis Mitigate Acute Kidney Injury via RONS Scavenging and Iron Ion Chelation.
Deciphering the role of the MALT1-RC3H1 axis in regulating GPX4 protein stability.
Gegen Qinlian Decoction inhibits liver ferroptosis in type 2 diabetes mellitus models by targeting Nrf2.
Ethyl acetate fraction of Thesium chinense Turcz. alleviates chronic obstructive pulmonary disease through inhibition of ferroptosis mediated by activating Nrf2/SLC7A11/GPX4 axis.
The RNA Demethyltransferase FTO Regulates Ferroptosis in Major Depressive Disorder.
Isovitexin targets SIRT3 to prevent steroid-induced osteonecrosis of the femoral head by modulating mitophagy-mediated ferroptosis.
Downregulation of ferroptosis-related ATF3 alleviates lupus nephritis progression.
Comprehensive Pan-Cancer Analysis and Functional Studies Reveal SLC2A6 as a Ferroptosis Modulator in Hepatocellular carcinoma.
Melanoma bone metastasis-induced osteocyte ferroptosis via the HIF1α-HMOX1 axis.
ZC3H13 may participate in the ferroptosis process of sepsis-induced cardiomyopathy by regulating the expression of Pnn and Rbm25.
Trehalose Inhibits ferroptosis Through Activating SIRT3/SOD2 Signaling Axis and Alleviates Brain Injury After Traumatic Brain Injury.
Ghrelin Induces Ferroptosis Resistance and M2 Polarization of Microglia to Alleviate Neuroinflammation and Cognitive Impairment in Alzheimer's Disease.
High Salt Exacerbates Myocardial Dysfunction In Vitro and In Vivo by Promoting SIRT1/Nrf2-Mediated Ferroptosis.
Chronic environmental exposure to polystyrene microplastics increases the risk of nonalcoholic fatty liver disease.
Ginkgetin enhances breast cancer radiotherapy sensitization by suppressing NRF2-HO-1 axis activity.
Artemisinin inhibits neuronal ferroptosis in Alzheimer's disease models by targeting KEAP1.
EFNA4-enhanced deubiquitination of SLC7A11 inhibits ferroptosis in hepatocellular carcinoma.
Iron-glucose oxidase nanogel assembly for amplified starvation-ferroptosis anti-tumor therapy.
Betulinic Acid Inhibits Glioma Progression by Inducing Ferroptosis Through the PI3K/Akt and NRF2/HO-1 Pathways.
Heat exposure promotes sarcopenia via gut microbiota-derived metabolites.
Muribaculum intestinale-derived 3-hydroxybutyric acid from Heterophyllin B attenuated pulmonary fibrosis through IDO1-mediated ferroptosis.
Lipid peroxidation inhibition by icaritin and its glycosides as a strategy to combat iron overload-induced osteoporosis in zebrafish.
Modulation of the local angiotensin II: Suppression of ferroptosis and radiosensitivity in nasopharyngeal carcinoma via the HIF-1α-HILPDA axis.
Long non-coding RNA MIR4435-2HG modulates pancreatic cancer stem cells and chemosensitivity to gemcitabine by targeting the miR-1252-5p/STAT1.
Praeruptorin A screened by a ferrous ion probe inhibited DMT1 and ferroptosis to attenuate Doxorubicin-induced cardiomyopathy.
Identification of Isoliensinine as a Ferroptosis Suppressor with Iron-Chelating Activity.
Novel Cell Models to Study Myelin and Microglia Interactions.
Changyanning tablet alleviates Crohn's disease by inhibiting GPX4-mediated ferroptosis.
The GPR30-Mediated BMP-6/HEP/FPN Signaling Pathway Inhibits Ferroptosis in Bone Marrow Mesenchymal Stem Cells to Alleviate Osteoporosis.
Oxygen Nanobubbles Enhance ICG/Fe(III)-Mediated Dual-Modal Therapy To Induce Ferroptosis in Tumor Treatment.
Targeting the Leukemia Inhibitory Factor/Leukemia Inhibitory Factor Receptor Axis Reduces the Growth of Inflammatory Breast Cancer by Promoting Ferroptosis.
Non-invasive in vivo monitoring of PROTAC-mediated protein degradation using an environment-sensitive reporter.
Superoxide dismutase promotes gastric tumorigenesis mediated by Helicobacter pylori and enhances resistance to 5-fluorouracil in gastric cancer.
GluOC Induced SLC7A11 and SLC38A1 to Activate Redox Processes and Resist Ferroptosis in TNBC.
Human spindle-shaped urine-derived stem cell exosomes alleviate severe fatty liver ischemia-reperfusion injury by inhibiting ferroptosis via GPX4.
Metformin Induces Apoptosis and Ferroptosis of Ovarian Cancer Cells Under Energy Stress Conditions.
Bio-nanocomplexes impair iron homeostasis to induce non-canonical ferroptosis in cancer cells.
Ferroptosis and PANoptosis under hypoxia pivoting on the crosstalk between DHODH and GPX4 in corneal epithelium.
IL-27 regulates macrophage ferroptosis by inhibiting the Nrf2/HO1 signaling pathway in sepsis-induced ARDS.
Lactate-Fueled Theranostic Nanoplatforms for Enhanced MRI-Guided Ferroptosis Synergistic with Immunotherapy of Hepatocellular Carcinoma.
β-elemene, a sesquiterpene constituent from Curcuma phaeocaulis inhibits the development of endometriosis by inducing ferroptosis via the MAPK and STAT3 signaling pathways.
The extract from Quzhou Aurantii Fructus attenuates cough variant asthma through inhibiting the TRPV1/Ca(2+)/NFAT/TSLP pathway and ferroptosis via TRPV1 mediation in ovalbumin-induced mice.
Coixol-Loaded Hydrogels Promote Osteochondral Defect Repair via Modulation of Ferroptosis and Autophagy in Chondrocytes.
Integrated network pharmacology, bioinformatics, and experiment analysis to decipher the molecular mechanism of Salidroside on Gastric cancer via targeting NCOA4-mediated ferritinophagy.
Puerarin reduces susceptibility to ventricular arrhythmias and inhibits ferroptosis via Sirt1/Nrf2 signaling in high-fat-diet rats.
Crucial roles of asprosin in cisplatin-induced ferroptosis and acute kidney injury.
Luteolin Inhibits Ferroptosis of HUVEC by Regulating the Sirt1/Nrf2 Pathway.
A photothermally triggered cascade bioreactor for cuproptosis and ferroptosis-driven cancer immunotherapy.
Indirubin regulates M1/M2 polarization and inhibits ferroptosis in dextran sulfate sodium induced colitis and in cultured THP-1 cells.
Exosomal miR-494 from Bone Marrow Mesenchymal Stem Cells Attenuates Ferroptosis and Enhances Spinal Cord Injury Repair by Modulating the SIRT1/HO-1 Pathway.
Propofol in combination with salvianolic acid A protect against lipopolysaccharide-induced cardiac dysfunction and ferroptosis through activating the SIRT1/FoxO1 signaling under diabetic condition.
Membrane-Associated RING-CH-Type Finger 6 Protects against Hypertension-Induced Cardiac Remodeling by Suppressing Cardiomyocyte Ferroptosis Through the Degradation of ACSL4.
Network pharmacology combined with experiments to explore the molecular mechanism of Jiawei Erzhi pill protects against atherosclerosis by inhibiting ferroptosis.
Ozonated olive oil inhibits melanoma proliferation by inducing ferroptosis.
Sodium butyrate enhances sorafenib-induced ferroptosis and immunogenic cell death by modulating IRF2-Oasl2-cGAS pathway in colorectal cancer.
A trojan horse selenium-containing polymer for protective co-delivery of Fe(II) and cisplatin to boost chemo-ferroptosis synergy via GSH-triggered ROS storm.
The umbilical cord blood exosome MFG-E8 alleviates hypoxic-ischemic encephalopathy brain injury in neonatal rats by restoring autophagy flux and inhibiting ferroptosis through GSK3β/β-catenin signaling.
High-Dose Ascorbic Acid Combined With Dihydroartemisinin Inhibits Lung Adenocarcinoma Malignancy by Inducing Ferroptosis via SLC7A11/GPX4 Pathway.
Bavachinin exerts anti-tumor effects by activating TLR4/STING axis-dependent PANoptosis and synergistically enhances chemosensitivity in endometrial cancer.
Oridonin mitigates bacterial pneumonia by regulating mitochondrial integrity and ferroptosis via targeting KEAP1/NRF2 signaling.
PFGA12 ameliorates Hypoxic-Ischemic brain injury by directly regulating PRDX1 and inhibiting ferroptosis.
Astaxanthin suppress ferroptosis through the Akt1-FoxO3a signaling pathway to alleviates brain injury after intracerebral hemorrhage.
Ethanol extract of Corydalis decumbens exerts neuroprotective effects against cerebral ischemia-reperfusion injury by targeting ALOX15 to suppress ferroptosis.
Multi-Enzymatic Cascade Catalysis in Photodynamic Nanozymes for Augmenting Radiotherapy of Breast Cancer.
CBX2 and EZH2 cooperatively contribute to 5-Fu resistance in gastric cancer by suppressing ferroptosis via trimethylation of H3k27.
Dauricine Inhibits Macrophages M2 Polarization and Regulates the Progression and Ferroptosis via HCK/IDO1 in Urinary Bladder Cancer.
Renal denervation attenuates cardiac dysfunction in HFpEF by inhibiting the ATP-P2X7-NLRP3 inflammasome axis.
Erucic Acid, Derived by Lactobacillus Crispatus, Induces Ferroptosis in Cervical Cancer Organoids Through the PPAR-δ Signaling Pathway.
Norepinephrine Induces Sertoli Cell Ferroptosis via Receptors Desensitization Causing Stress-Related Male Reproductive Dysfunction.
Exploring Functionally Enhanced BLP-Trained Macrophage Subpopulations in S. Aureus Infection: Underlying Mechanisms and Therapeutic Significance.
Tumor redox heterogeneity-responsive nanoparticles for enhanced antitumor efficacy through combining chemo/chemodynamic therapy.
Investigating Nickel-Induced Neurotoxicity: Associations with Gut Microbiota Dysbiosis and Ferroptosis.
Functional nano-nucleic acid platform promotes copper-induced gastric cancer cell death.
Heterogeneity of active mast cells, endothelial cells, and fibroblasts in hemophilic arthritis defined by synovial single-cell sequencing.
Discovery of a selenium-containing compound as a promising ferroptosis inducer attenuates prostate cancer progression.
Nicotinamide Mononucleotide Alleviates the Development of Fibrotic Cataract by Modulating the Nrf2/FPN1 Signaling Pathway.
Echinacoside as a Novel Ferroptosis Inducer in Hepatocellular Carcinoma: Mechanistic Insights from TP53/SLC7A11/GPX4 Pathway Modulation.
CXCR4-engineered fibroblast membrane nanovesicles for Photothermal-enhanced ferroptotic therapy through chemokine-navigated tumor homing.
The protective role of TRIM16 in rheumatoid arthritis: mechanisms of modulating ferroptosis.
TCF3 activates super-enhancer-driven TRIB2 overexpression to suppress ferroptosis and promote hepatoblastoma proliferation.
Cytochrome c Oxidase Subunit COX4-1 Reprograms Erastin-Induced Cell Death from Ferroptosis to Apoptosis: A Transmitochondrial Study.
α-Linolenic Acid Alleviates Diabetic Cardiomyopathy by Activating AMPK-STAT3 Pathway to Inhibit Ferritinophagy and Enhance SLC7A11-GPX4 Antioxidant Axis.
Senescence-Primed Ferroptosis Enabled by a Metal-Organic Framework Nanoplatform for Enhanced Cancer Therapy.
NEDD4 suppresses ferroptosis in lung ischemia-reperfusion injury by ubiquitinating and degrading SLC1A5.
Targeting the SMAD3/CISD2 axis suppresses bladder cancer progression by promoting ferroptosis in mesenchymal-like bladder cancer cells.
Microglial RUNX1/RBM47 ablation inhibits neuronal ferroptosis via regulating the cGAS-STING-MEF2C pathway in mice with postoperative cognitive dysfunction.
Synergistic Proteolysis Targeting Chimera Chemotherapy Conjugate for Potent Non-small Cell Lung Cancer Treatment.
The FAK-NRF2 Axis Alleviates DOX-Induced Cardiotoxicity by Inhibiting Ferroptosis.
Design, synthesis, and biological evaluation of arctigenin derivatives as novel GPX4 inhibitors in colorectal cancer cells.
HPDA-based tubule-targeting nanoplatform alleviates oxidative stress and ferroptosis for the reversal of renal interstitial fibrosis.
Melanoma MHC-I-membrane-encapsulated Cu@ferrihydrite induces ferroptosis/cuproptosis and systematic immunity against tumor.
FERMT1 suppresses the ferroptosis of glioma cells by interacting with MBOAT2.
Exercise training ameliorates high-fat diet-induced skeletal muscle atrophy and ferroptosis via downregulation of STING.
Baicalein attenuates metabolic dysfunction-associated steatohepatitis by regulating macrophage ferroptosis through nuclear factor (erythroid-derived 2)-like 2 pathway.
Curcumin derivatives as ferroptosis inducers: design, synthesis and anti breast cancer activity evaluation.
Inhibition of Mettl3-mediated m6A RNA modification of HMGCS1 protects retinal ganglion cells from glutamate excitotoxicity-induced ferroptosis in a rat model of glaucoma.
Anticancer activity of Momordica charantia-derived extracellular vesicle-like particle against cervical cancer.
Salidroside sensitizes Triple-negative breast cancer to ferroptosis by SCD1-mediated lipogenesis and NCOA4-mediated ferritinophagy.
A Common Mutation in the Homeostatic Iron Regulatory Gene Alters Astrocyte Migration and Redox Profile.
Arbutin Preserves Boar Sperm During Storage at 17°C by Enhancing the Antioxidant Capacity via the NRF2/GPX4 Signalling.
SGLT2i continuously prevents cardiac hypertrophy by reducing ferroptosis via AMPK up-regulation.
SETD5 facilitates stemness and represses ferroptosis via m6A-mediating PKM2 stabilization in non-small cell lung cancer.
Lactoferrin prevents heat stroke-induced intestinal barrier damage by reducing ferroptosis via regulating MAPK signaling pathway: In vitro and in vivo studies.
Excessive ultra-processed foods exposure aggravates ulcerative colitis via macrophage ferroptosis.
GPX4 degradation contributes to heat stress-induced liver injury via chaperone-mediated autophagy.
Hydroxysafflor yellow A inhibits neuronal ferroptosis and ferritinophagy in ischemic stroke.
F-box only protein 10 protects against kidney tubulointerstitial fibrosis by inhibiting ACSL4-mediated lipid peroxidation and ferroptosis.
Targeting GPX4 to Induce Ferroptosis Overcomes Chemoresistance Mediated by the PAX8-AS1/GPX4 Axis in Intrahepatic Cholangiocarcinoma.
FSP1 and CoQ10 have the potential to serve as biomarkers for severe preeclampsia.
TCF7L2 regulates GPX4 to resist ferroptosis and enhance osteogenesis in mouse mesenchymal stem cells.
Inhibition of ferroptosis in inflammatory macrophages alleviates intestinal injury in neonatal necrotizing enterocolitis.
FTO-mediated the destabilization of RASGRF1 mRNA impedes thyroid cancer progression and suppresses macrophage M2 polarization.
Trimethylamine N-oxide Induced Chronic Kidney Injury by Triggering PANoptosis.
WTAP Dysregulation Mediates HLF-m6A Modification to Inhibit Trophoblast Ferroptosis in Preeclampsia.
Maimendong decoction and its active ingredient, ophiopogonin D, alleviate bleomycin-induced pulmonary fibrosis by regulating the behavior of lung fibroblasts.
Cancer-associated fibroblast-derived fibulin-5 promotes radioresistance in non-small-cell lung cancer.
USP18 promotes ferroptosis in lipopolysaccharide-induced human kidney organoids by stabilizing STING1.
METTL5 regulates SEPHS2-mediated selenoprotein synthesis to promote multiple myeloma survival and progression.
Effect of Self-Assembled Polydopamine Nanoparticles on Ferroptosis in an MPTP-Induced Parkinson's Disease Mice Model.
TIPE2 suppresses ferroptosis and pro-inflammatory polarization in macrophages triggered by SARS-CoV-2 spike protein.
Recharacterization of the Tumor Suppressive Mechanism of RSL3 Identifies the Selenoproteome as a Druggable Pathway in Colorectal Cancer.
Exosomal SLC1A5 from senescent endothelial cells promotes gastric cancer progression by dampening ferroptosis via the EGFR/SRC/YAP1/GPX4 signaling.
Fut8 regulated Unc5b hyperfucosylation reduces macrophage emigration and accelerates atherosclerosis development via the ferroptosis pathway.
Dental pulp stem cells derived exosomes inhibit ferroptosis via regulating the Nrf2-keap1/GPX4 signaling pathway to ameliorate chronic kidney disease injury.
Quercetin alleviates LPS/iE-DAP-induced liver injury by suppressing ferroptosis via regulating ferritinophagy and intracellular iron efflux.
Histone lactylation drives liver cancer metastasis by facilitating NSF1-mediated ferroptosis resistance after microwave ablation.
TGF-β1 induces ROS to activate ferroptosis via the ERK1/2-WISP1 pathway to promote the progression of renal tubular epithelial cell fibrosis.
Esketamine alleviated cardiomyocyte ferroptosis induced by oxygen-glucose deprivation/reoxygenation (OGD/R) via cyclic GMP-AMP synthase interactor.
Caffeine improves hypoxia/reoxygenation induced neuronal cell injury through inhibiting cellular ferroptosis: an in vitro study.
Heliox alleviates ischemia-reperfusion-induced damage to neuronal cells by repressing the USP46-SNX5 Axis-triggered ferroptosis.
Hyaluronic acid-functionalized nanoparticles enable enhanced chemo/chemodynamic therapy for the targeted treatment of colon cancer.
FePt/MnO(2)@PEG Nanoparticles as Multifunctional Radiosensitizers for Enhancing Ferroptosis and Alleviating Hypoxia in Osteosarcoma Therapy.
Nrf2 alleviates acute ischemic stroke induced ferroptosis via regulating xCT/GPX4 pathway.
Pharmacological Inhibition of TXNRD1 by a Small Molecule Flavonoid Butein Overcomes Cisplatin Resistance in Lung Cancer Cells.
Amino-modified IONPs potentiates ferroptotic cell death due to the release of Fe ion in the lysosome.
β-Diketone Functionalized Microspheres Chelate Reactive Iron via Metal Coordination for Cartilage Repair.
Elevated serum levels of GPX4, NDUFS4, PRDX5, and TXNRD2 as predictive biomarkers for castration resistance in prostate cancer patients: an exploratory study.
Canagliflozin-induced renal glutathione distribution mapping in non-diabetic male rat kidneys.
Dapagliflozin alleviates high-fat-induced obesity cardiomyopathy by inhibiting ferroptosis.
3-D Sustained-Release Culture Carrier Alleviates Rat Intervertebral Disc Degeneration by Targeting STING in Transplanted Skeletal Stem Cells.
Short-term effects of subacute ruminal acidosis on ferroptosis and iron metabolism in the livers of lactating sheep fed a high-grain diet.
Tanshinone IIA Ameliorates Myocardial Ischemia-Reperfusion Injury via Activating HDAC1-Repressed Nrf2-xCT/Gpx4/HO-1 Axis.
New insights into ovarian regression-related mitochondrial dysfunction in the late-laying period.
Tangshenning formula alleviates tubular injury in diabetic kidney disease via the Sestrin2/AMPK/PGC-1α axis: Restoration of mitochondrial function and inhibition of ferroptosis.
The long noncoding RNA APR attenuates PPRV infection-induced accumulation of intracellular iron to inhibit membrane lipid peroxidation and viral replication.
Mechanism of Mitophagy to Protect Yak Kidney from Hypoxia-Induced Fibrosis Damage by Regulating Ferroptosis Pathway.
Pharmacological targeting of the mitochondrial phosphatase PTPMT1 sensitizes hepatocellular carcinoma to ferroptosis.
Inhibition of mitochondrial complex I induces mitochondrial ferroptosis by regulating CoQH2 levels in cancer.
Notopterol mitigates osteoarthritis progression and relieves pain in mice by inhibiting PI3K/Akt/GPX4-mediated ferroptosis.
Identification of HCAR1 as a ferroptosis-related biomarker of gastric cancer based on a novel ferroptosis-related prognostic model and in vitro experiments.
Impact of diabetes and metformin on cuproptosis and ferroptosis in breast cancer patients: an immunohistochemical analysis.
TAZ/NRF2 positive feedback loop contributes to proliferation in bladder cancer through antagonistic ferroptosis.
Inhibition of ferroptosis alleviates atherosclerosis and foam cell formation by regulating lipid metabolism via AMPK activation.
Transcription factor FOS promotes ferroptosis and inflammation in S. aureus- infected osteomyelitis via EIF5A.
Electroacupuncture improves cognitive function in high-fat diet/streptozocin-induced type 2 diabetic mice by inhibiting autophagy-related ferroptosis.
RNF128 promotes gastric cancer progression by inhibiting autophagy-dependent ferroptosis through Beclin1 ubiquitination.
Unraveling the crucial role of SDF-1 in osteoarthritis progression: IL6/HIF-1α positive feedback and chondrocyte ferroptosis.
FADS2 inhibits colorectal cancer cell proliferation by regulating ferroptosis through SLC7A11/GPX4.
Artesunate induces ferroptosis in osteosarcoma through NCOA4-mediated ferritinophagy.
Cold atmospheric plasma drives USP49/HDAC3 axis mediated ferroptosis as a novel therapeutic strategy in endometrial cancer via reinforcing lactylation dependent p53 expression.
TMEM160 inhibits KEAP1 to suppress ferroptosis and induce chemoresistance in gastric cancer.
A Nutrient-Deficient Microenvironment Facilitates Ferroptosis Resistance via the FAM60A-PPAR Axis in Pancreatic Ductal Adenocarcinoma.
GPX4 inhibits apoptosis of thyroid cancer cells through regulating the FKBP8/Bcl-2 axis.
Berberine alleviates AGEs-induced ferroptosis by activating NRF2 in the skin of diabetic mice.
Connexin43 overexpression promoted ferroptosis and increased myocardial vulnerability to ischemia-reperfusion injury in type 1 diabetic mice.
PRDX1 inhibits ferroptosis by binding to Cullin-3 as a molecular chaperone in colorectal cancer.
Ferroptosis-related gene MAPK3 is associated with the neurological outcome after cardiac arrest.
Electroacupuncture ameliorates depression-like behaviors in rats with post-stroke depression by inhibiting ferroptosis in the prefrontal cortex.
Propofol and Dexmedetomidine Ameliorate Endotoxemia-Associated Encephalopathy via Inhibiting Ferroptosis.
Gandouling Regulates Ferroptosis and Improves Neuroinflammation in Wilson's Disease Through the LCN2/NLRP3 Signaling Pathway.
Artemether regulates liver glycogen and lipid utilization through mitochondrial pyruvate oxidation in db/db mice.
miR-141-3p promotes paclitaxel resistance by attenuating ferroptosis via the Keap1-Nrf2 signaling pathway in breast cancer.
Polydatin protects against DSS-induced ulcerative colitis via Nrf2/Slc7a11/Gpx4-dependent inhibition of ferroptosis signalling activation.
Calycosin alleviates ferroptosis and attenuates doxorubicin-induced myocardial injury via the Nrf2/SLC7A11/GPX4 signaling pathway.
Shikonin suppresses proliferation of osteosarcoma cells by inducing ferroptosis through promoting Nrf2 ubiquitination and inhibiting the xCT/GPX4 regulatory axis.
A novel hollow iron nanoparticle system loading PEG-Fe(3)O(4) with C5a receptor antagonist for breast cancer treatment.
Transcription factor MEF2D regulates aberrant expression of ACSL3 and enhances sorafenib resistance by inhibiting ferroptosis in HCC.
Combination decoction of Astragalus mongholicus and Salvia miltiorrhiza mitigates pressure-overload cardiac dysfunction by inhibiting multiple ferroptosis pathways.
Multidimensional role of adapalene in regulating cell death in multiple myeloma.
LSD1 inhibition by tranylcypromine hydrochloride reduces alkali burn-induced corneal neovascularization and ferroptosis by suppressing HIF-1α pathway.
Rabeprazole suppressed gastric intestinal metaplasia through activation of GPX4-mediated ferroptosis.
Discovery of ferroptosis-related genes in renal ischemia reperfusion and evaluate the potential impact on kidney transplantation.
Surufatinib combined with photodynamic therapy induces ferroptosis to inhibit cholangiocarcinoma in vitro and in tumor models.
Photoreceptor-targeted extracellular vesicles-mediated delivery of Cul7 siRNA for retinal degeneration therapy.
Expression of GPX4 by oncolytic vaccinia virus can significantly enhance CD8(+)T cell function and its impact against pancreatic ductal adenocarcinoma.
Propofol and salvianolic acid A synergistically attenuated cardiac ischemia-reperfusion injury in diabetic mice via modulating the CD36/AMPK pathway.
NU7441, a selective inhibitor of DNA-PKcs, alleviates intracerebral hemorrhage injury with suppression of ferroptosis in brain.
Unveiling the mechanism of photothermal therapy in acne man-agement: targeting sebaceous gland ferroptosis via umbilical cord mesenchymal stem cell membrane-encapsulated Au-Ag-PDA.
TYMS Knockdown Suppresses Cells Proliferation, Promotes Ferroptosis via Inhibits PI3K/Akt/mTOR Signaling Pathway Activation in Triple Negative Breast Cancer.
Melatonin Alleviates Osteoarthritis by Regulating NADPH Oxidase 4-Induced Ferroptosis and Mitigating Mitochondrial Dysfunction.
Vitamin E and GPX4 cooperatively protect treg cells from ferroptosis and alleviate intestinal inflammatory damage in necrotizing enterocolitis.
CREG1 attenuates doxorubicin-induced cardiotoxicity by inhibiting the ferroptosis of cardiomyocytes.
Nanoparticles targeting OPN loaded with BY1 inhibits vascular restenosis by inducing FTH1-dependent ferroptosis in vascular smooth muscle cells.
Gandouling ameliorates liver injury in Wilson's disease through the inhibition of ferroptosis by regulating the HSF1/HSPB1 pathway.
NOX1 triggers ferroptosis and ferritinophagy, contributes to Parkinson's disease.
Elucidating the molecular mechanisms behind the therapeutic impact of median nerve stimulation on cognitive dysfunction post-traumatic brain injury.
MiR-1909-5p targeting GPX4 affects the progression of aortic dissection by modulating nicotine-induced ferroptosis.
Identification and validation of ferroptosis-related hub genes and immune infiltration in liver ischemia-reperfusion injury.
RAB17 promotes endometrial cancer progression by inhibiting TFRC-dependent ferroptosis.
Prediction and verification of targets for α-hederin/oxaliplatin dual-loaded rHDL modified liposomes: Reversing effector T-cells dysfunction and improving anti-COAD efficiency in vitro and in vivo.
Aldo-Keto reductase 1C3 reduces myocardial cell damage after acute myocardial infarction by activating the Kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2-antioxidant response element pathway to inhibit ferroptosis.
Heat Shock Protein 90 Interactome-Mediated Proteolysis Targeting Chimera (HIM-PROTAC) Degrading Glutathione Peroxidase 4 to Trigger Ferroptosis.
Ursolic Acid Ameliorates Alcoholic Liver Injury through Attenuating Oxidative Stress-Mediated Ferroptosis and Modulating Gut Microbiota.
SGLT2 inhibition mitigates transition from acute kidney injury to chronic kidney disease by suppressing ferroptosis.
Engineering Biodegradable Hollow Silica/Iron Composite Nanozymes for Breast Tumor Treatment through Activation of the "Ferroptosis Storm".
Cerebroprotein hydrolysate-I ameliorates cognitive dysfunction in APP/PS1 mice by inhibiting ferroptosis via the p53/SAT1/ALOX15 signalling pathway.
Ellagic acid ameliorates arsenic-induced neuronal ferroptosis and cognitive impairment via Nrf2/GPX4 signaling pathway.
Co-delivery of siRNA and cisplatin via electrospun Nanofibrous membranes for synergistic treatment of malignant melanoma.
Oxidative stress induces ferroptosis in tendon stem cells by regulating mitophagy through cGAS-STING pathway.
Neuronal ferroptosis and ferroptosis-mediated endoplasmic reticulum stress: Implications in cognitive dysfunction induced by chronic intermittent hypoxia in mice.
Autophagy aggravates multi-walled carbon nanotube-induced ferroptosis by suppressing PGC-1 dependent-mitochondrial biogenesis in lung epithelial cells.
Borna disease virus 1 induces ferroptosis, contributing to lethal encephalitis.
Targeting GPX4-mediated ferroptosis protection sensitizes BRCA1-deficient cancer cells to PARP inhibitors.
LOX-mediated ECM mechanical stress induces Piezo1 activation in hypoxic-ischemic brain damage and identification of novel inhibitor of LOX.
The Syvn1 inhibits neuronal cell ferroptosis by activating Stat3/Gpx4 axis in rat with spinal cord injury.
Cytochrome P450 F3 promotes colorectal cancer via inhibiting NRF2-mediated ferroptosis.
Ferroptosis contributes to diabetes-induced visual pathway neuronal damage via iron accumulation and GPX4 inactivation.
MEF2C Alleviates Postoperative Cognitive Dysfunction by Repressing Ferroptosis.
CuO Nanozymes Catalyze Cysteine and Glutathione Depletion Induced Ferroptosis and Cuproptosis for Synergistic Tumor Therapy.
FTO alleviated ferroptosis in septic cardiomyopathy via mediating the m6A modification of BACH1.
Sulforaphane improves post-resuscitation myocardial dysfunction by inhibiting cardiomyocytes ferroptosis via the Nrf2/IRF1/GPX4 pathway.
Artemether ameliorates acetaminophen-induced liver injury through Nrf2 pathway.
Inhibition of HOXC11 by artesunate induces ferroptosis and suppresses ovarian cancer progression through transcriptional regulation of the PROM2/PI3K/AKT pathway.
Ferroptosis Regulated by 5-HT3a Receptor via Calcium/Calmodulin Signaling Contributes to Neuropathic Pain in Brachial Plexus Avulsion Rat Models.
GZMA suppressed GPX4-mediated ferroptosis to improve intestinal mucosal barrier function in inflammatory bowel disease.
MDH2 Promotes Hepatocellular Carcinoma Growth Through Ferroptosis Evasion via Stabilizing GPX4.
Suppression of ferroptosis through the SLC7A11/glutathione/glutathione peroxidase 4 axis contributes to the therapeutic action of the Tangshenning formula on diabetic renal tubular injury.
Hyperbaric Oxygen Improves Cognitive Impairment Induced by Hypoxia via Upregulating the Expression of Oleic Acid and MBOAT2 of Mice.
The regulation of GSH/GPX4-mediated lipid accumulation confirms that schisandra polysaccharides should be valued equally as lignans.
A respiratory Streptococcus strain inhibits Acinetobacter baumannii from causing inflammatory damage through ferroptosis.
Human breast milk-derived phospholipid DOPE ameliorates intestinal injury associated with NEC by inhibiting ferroptosis.
The effect of norepinephrine on ovarian dysfunction by mediating ferroptosis in mice model.
Upregulation of PRRX2 by silencing Marveld3 as a protective mechanism against radiation-induced ferroptosis in skin cells.
AMPD3 promotes doxorubicin-induced cardiomyopathy through HSP90α-mediated ferroptosis.
Magnetic-vortex nanodonuts enhance ferroptosis effect of tumor ablation through an imaging-guided hyperthermia/radiosensitization strategy.
CD8+ T cell associated scoring model helps prognostic diagnosis and immunotherapy selection in patients with colon adenocarcinoma.
PRODH Regulates Tamoxifen Resistance through Ferroptosis in Breast Cancer Cells.
PF-PEG@ASIV-EXO Hydrogel Accelerates Diabetic Wound Healing by Ferroptosis Resistance and Promoting Angiogenesis.
Iron-laden macrophage-mediated paracrine profibrotic signaling induces lung fibroblast activation.
A precise microdissection strategy enabled spatial heterogeneity analysis on the targeted region of formalin-fixed paraffin-embedded tissues.
Serum apolipoprotein H determines ferroptosis resistance by modulating cellular lipid composition.
Unveiling the crucial role of ferroptosis in host resistance to streptococcus agalactiae infection.
Silibinin attenuates ferroptosis in acute kidney injury by targeting FTH1.
Rituximab induces ferroptosis and RSL3 overcomes rituximab resistance in diffuse large B-cell lymphoma cells.
Sodium citrate targeting Ca(2+)/CAMKK2 pathway exhibits anti-tumor activity through inducing apoptosis and ferroptosis in ovarian cancer.
Ferritinophagy is involved in hexavalent chromium-induced ferroptosis in Sertoli cells.
USP14 increases the sensitivity of retinoblastoma to cisplatin by mediating the ferroptosis.
Intra-articular injection of platinum nanozyme-loaded silk fibroin/pullulan hydrogels relieves osteoarthritis through ROS scavenging and ferroptosis suppression.
Cancer cell membrane-camouflaged curcumin nanoparticles trigger ferroptosis for accurate gastric cancer therapy.
Mn(II)-Aloe-Emodin Nanoscale Coordination Polymer Enhances Ferroptosis by Synergistically Enhancing Reactive Oxygen Species Generation via the Nrf2-GPX4 Axis.
IL6 Derived from Macrophages under Intermittent Hypoxia Exacerbates NAFLD by Promoting Ferroptosis via MARCH3-Led Ubiquitylation of GPX4.
Role of PI3K/AKT signaling pathway involved in self-renewing and maintaining biological properties of chicken primordial germ cells.
Repurposed genipin targeting UCP2 exhibits antitumor activity through inducing ferroptosis in glioblastoma.
BRAF-Mutated Melanoma Cell Lines Develop Distinct Molecular Signatures After Prolonged Exposure to AZ628 or Dabrafenib: Potential Benefits of the Antiretroviral Treatments Cabotegravir or Doravirine on BRAF-Inhibitor-Resistant Cells.
Iberverin Downregulates GPX4 and SLC7A11 to Induce Ferroptotic Cell Death in Hepatocellular Carcinoma Cells.
MT1E in AML: a gateway to understanding regulatory cell death and immunotherapeutic responses.
Role of ferroptosis in mitochondrial damage in diabetic retinopathy.
25-Hydroxycholecalciferol Improves Cardiac Metabolic Adaption, Mitochondrial Biogenetics, and Redox Status to Ameliorate Pathological Remodeling and Functional Failure in Obese Chickens.
Fibroblast growth factor 21 improves diabetic cardiomyopathy by inhibiting ferroptosis via ferritin pathway.
Nutritional Glutamine-Modified Iron-Delivery System with Enhanced Endocytosis for Ferroptosis Therapy of Pancreatic Tumors.
Huperzine A protected against ferroptosis via activating PI3K/Akt signaling in lipopolysaccharide induced acute lung injury.
Total extracts from Abelmoschus manihot (L.) alleviate radiation-induced cardiomyocyte ferroptosis via regulating redox imbalances mediated by the NOX4/xCT/GPX4 axis.
Carthamin yellow alleviates dextran sodium sulfate-induced ulcerative colitis by repairing the intestinal barrier and activating the Nrf2/GPX4 axis.
Immune Checkpoint-Modulating Photosensitizer That Targets BRD4 for Cancer Photoimmunotherapy.
MDM4 inhibits ferroptosis in p53 mutant colon cancer via regulating TRIM21/GPX4 expression.
LncRNA MALAT1 promotes Erastin-induced ferroptosis in the HBV-infected diffuse large B-cell lymphoma.
LncRNA MALAT1-Targeting Antisense Oligonucleotide Ameliorates the AngII-Induced Vascular Smooth Muscle Cell Proliferation and Migration Through Nrf2/GPX4 Antioxidant Pathway.
Treatment of Parkinson's disease model with human umbilical cord mesenchymal stem cell-derived exosomes loaded with BDNF.
Platycodin D ameliorates polycystic ovary syndrome-induced ovarian damage by upregulating CD44 to attenuate ferroptosis.
The effect of tau K677 lactylation on ferritinophagy and ferroptosis in Alzheimer's disease.
Epithelial Piezo1 deletion ameliorates intestinal barrier damage by regulating ferroptosis in ulcerative colitis.
Identification of ROS and KEAP1-related genes and verified targets of α-hederin induce cell death for CRC.
Icariin‑curcumol promotes ferroptosis in prostate cancer cells through Nrf2/HO‑1 signaling.
N-acetylcysteine Protects Against Myocardial Ischemia-Reperfusion Injury Through Anti-ferroptosis in Type 1 Diabetic Mice.
Iron (II)-based metal-organic framework nanozyme for boosting tumor ferroptosis through inhibiting DNA damage repair and system Xc().
LncRNA-PVT1 Inhibits Ferroptosis through Activating STAT3/GPX4 Axis to Promote Osteosarcoma Progression.
MiR-31-5p alleviates septic cardiomyopathy by targeting BAP1 to inhibit SLC7A11 deubiquitination and ferroptosis.
Ficolin 3 promotes ferroptosis in HCC by downregulating IR/SREBP axis-mediated MUFA synthesis.
αO-Conotoxin GeXIVA[1,2] Suppresses In Vivo Tumor Growth of Triple-Negative Breast Cancer by Inhibiting AKT-mTOR, STAT3 and NF-κB Signaling Mediated Proliferation and Inducing Apoptosis.
Label-Free Three-Dimensional Morphological Characterization of Cell Death Using Holographic Tomography.
Exploring the anti-ferroptosis mechanism of Kai-Xin-San against Alzheimer's disease through integrating network pharmacology, bioinformatics, and experimental validation strategy in vivo and in vitro.
Brusatol hinders the progression of bladder cancer by Chac1/Nrf2/SLC7A11 pathway.
Cadmium exposure induced neuronal ferroptosis and cognitive deficits via the mtROS-ferritinophagy pathway.
Ischemia-inhibited ferric chelate reductase 1 improves ferroptosis-mediated intestinal ischemia injury via Hippo signaling.
MiR-122-5p regulates erastin-induced ferroptosis via CS in nasopharyngeal carcinoma.
Design, synthesis, and evaluation of formylpiperazine analogs of Ferrostatin-1 as novel improved ferroptosis inhibitors.
Therapeutic potential and mechanisms of Rifaximin in ameliorating iron overload-induced ferroptosis and liver fibrosis in vivo and in vitro.
Ca & Mn dual-ion hybrid nanostimulator boosting anti-tumor immunity via ferroptosis and innate immunity awakening.
Glutathione depletion and dihydroorotate dehydrogenase inhibition actuated ferroptosis-augment to surmount triple-negative breast cancer.
The opposite role of lactate dehydrogenase a (LDHA) in cervical cancer under energy stress conditions.
Sestrin2 reduces ferroptosis via the Keap1/Nrf2 signaling pathway after intestinal ischemia-reperfusion.
Propionate promotes ferroptosis and apoptosis through mitophagy and ACSL4-mediated ferroptosis elicits anti-leukemia immunity.
Enhanced glutathione production protects against zearalenone-induced oxidative stress and ferroptosis in female reproductive system.
DTTZ suppresses ferroptosis and reverses mitochondrial dysfunction in normal tissues affected by chemotherapy.
Design, Synthesis, and Biological Evaluation of Hydrophobic-Tagged Glutathione Peroxidase 4 (GPX4) Degraders.
GSTM3 enhances radiosensitivity of nasopharyngeal carcinoma by promoting radiation-induced ferroptosis through USP14/FASN axis and GPX4.
Biomimetic Nanoarchitectonics with Chitosan Nanogels for Collaborative Induction of Ferroptosis and Anticancer Immunity for Cancer Therapy.
LuQi formula attenuates Cardiomyocyte ferroptosis via activating Nrf2/GPX4 signaling axis in heart failure.
VDR Activation Attenuates Renal Tubular Epithelial Cell Ferroptosis by Regulating Nrf2/HO-1 Signaling Pathway in Diabetic Nephropathy.
Polyphyllin B inhibited STAT3/NCOA4 pathway and restored gut microbiota to ameliorate lung tissue injury in cigarette smoke-induced mice.
NRF2 activation ameliorates blood-brain barrier injury after cerebral ischemic stroke by regulating ferroptosis and inflammation.
Silent information regulator sirtuin 1 ameliorates acute liver failure via the p53/glutathione peroxidase 4/gasdermin D axis.
Mechanism of Dendrobium Nobile Polysaccharide Inhibition of Ferroptosis in Rats with Spinal Cord Injury.
The E3 ligase TRIM7 suppresses the tumorigenesis of gastric cancer by targeting SLC7A11.
TfR1 mediated iron metabolism dysfunction as a potential therapeutic target for osteoarthritis.
Tetrahydrobiopterin inhibitor-based antioxidant metabolic strategy for enhanced cancer ferroptosis-immunotherapy.
Cardiomyocyte-fibroblast interaction regulates ferroptosis and fibrosis after myocardial injury.
Cyclin-dependent kinase inhibitor 1A inhibits pyroptosis to enhance human lung adenocarcinoma cell radioresistance by promoting DNA repair.
SAP130 released by ferroptosis tubular epithelial cells promotes macrophage polarization via Mincle signaling in sepsis acute kidney injury.
Glyphosate drives autophagy-dependent ferroptosis to inhibit testosterone synthesis in mouse Leydig cells.
Acupuncture alleviates CUMS-induced depression-like behaviors of rats by regulating oxidative stress, neuroinflammation and ferroptosis.
Moderate mechanical stress suppresses chondrocyte ferroptosis in osteoarthritis by regulating NF-κB p65/GPX4 signaling pathway.
Cell-Cycle-related Protein Centromere Protein F Deficiency Inhibits Cervical Cancer Cell Growth by Inducing Ferroptosis Via Nrf2 Inactivation.
Changes of RNA m(6)A/m(5)C Modification Regulatory Molecules in Ferroptosis of T2DM Rat Pancreas.
A Disintegrin and Metalloproteinase-8 Protects Against Erastin-Induced Neuronal Ferroptosis via Activating Nrf2/HO-1/FTH1 Signaling Pathway.
Nicorandil Regulates Ferroptosis and Mitigates Septic Cardiomyopathy via TLR4/SLC7A11 Signaling Pathway.
Photodynamic therapy inhibits cancer progression and induces ferroptosis and apoptosis by targeting P53/GPX4/SLC7A11 signaling pathways in cholangiocarcinoma.
YTHDF2 Promotes Cardiac Ferroptosis via Degradation of SLC7A11 in Cardiac Ischemia-Reperfusion Injury.
Licochalcone A alleviates ferroptosis in doxorubicin-induced cardiotoxicity via the PI3K/AKT/MDM2/p53 pathway.
Targeting NKAα1 to treat Parkinson's disease through inhibition of mitophagy-dependent ferroptosis.
Downregulated GPX4 in salivary gland epithelial cells contributes to salivary secretion dysfunction in Sjogren's syndrome via lipid ROS/pSTAT4/AQP5 axis.
Cu(2)WS(4)-PEG Nanozyme as Multifunctional Sensitizers for Enhancing Immuno-Radiotherapy by Inducing Ferroptosis.
Botulinum toxin A attenuates osteoarthritis development via inhibiting chondrocyte ferroptosis through SLC7Al1/GPX4 axis.
Gut microbiota regulates the ALK5/NOX1 axis by altering glutamine metabolism to inhibit ferroptosis of intrahepatic cholangiocarcinoma cells.
Stanniocalcin 2 Regulates Autophagy and Ferroptosis in Mammary Epithelial Cells of Dairy Cows Through the Mechanistic Target of Rapamycin Complex 1 Pathway.
MaiJiTong granule attenuates atherosclerosis by reducing ferroptosis via activating STAT6-mediated inhibition of DMT1 and SOCS1/p53 pathways in LDLR(-/-) mice.
Tau Aggregation-Dependent Lipid Peroxide Accumulation Driven by the hsa_circ_0001546/14-3-3/CAMK2D/Tau Complex Inhibits Epithelial Ovarian Cancer Peritoneal Metastasis.
N6022 attenuates cerebral ischemia/reperfusion injury-induced microglia ferroptosis by promoting Nrf2 nuclear translocation and inhibiting the GSNOR/GSTP1 axis.
Remote Ischemic Postconditioning-Mediated Neuroprotection against Stroke by Promoting Ketone Body-Induced Ferroptosis Inhibition.
Bioactive compound schaftoside from Clinacanthus nutans attenuates acute liver injury by inhibiting ferroptosis through activation the Nrf2/GPX4 pathway.
Exploration and Validation of Ferroptosis-Associated Genes in ADAR1 Deletion-Induced NAFLD through RNA-seq Analysis.
ROS-responsive MSC-derived Exosome Mimetics Carrying MHY1485 Alleviate Renal Ischemia Reperfusion Injury through Multiple Mechanisms.
ERRFI1 exacerbates hepatic ischemia reperfusion injury by promoting hepatocyte apoptosis and ferroptosis in a GRB2-dependent manner.
Rack1-mediated ferroptosis affects hindgut development in rats with anorectal malformations: Spatial transcriptome insights.
Sleeve gastrectomy links the attenuation of diabetic kidney disease to the inhibition of renal tubular ferroptosis through down-regulating TGF-β1/Smad3 signaling pathway.
GPX7 reduces chondrocyte inflammation and extracellular matrix degradation triggered by IL‑1β, via a mechanism mediated by ferroptosis.
Dihydroartemisinin induces ferroptosis in T cell acute lymphoblastic leukemia cells by downregulating SLC7A11 and activating the ATF4‑CHOP signaling pathway.
Berberine synergises with ferroptosis inducer sensitizing NSCLC to ferroptosis in p53-dependent SLC7A11-GPX4 pathway.
Baicalin promotes the sensitivity of NSCLC to cisplatin by regulating ferritinophagy and macrophage immunity through the KEAP1-NRF2/HO-1 pathway.
Leonurine Ameliorates Diabetic Nephropathy through GPX4-Mediated Ferroptosis of Endothelial Cells.
Quercetin inhibits neuronal Ferroptosis and promotes immune response by targeting lipid metabolism-related gene PTGS2 to alleviate breast cancer-related depression.
Overexpression of transcription factor TBX5 inhibits the activation of YAP1-TEAD1 pathway to promote ferroptosis in lung cancer cells.
Hesperetin Alleviated Experimental Colitis via Regulating Ferroptosis and Gut Microbiota.
Mitochondrial miR-12294-5p-Regulated Copper Exposure-Caused Mitochondrial-Dependent Ferroptosis by Targeted Inhibition of CISD1 in Chicken Hepatocytes.
Ultrasound-responsive Bi(2)MoO(6)-MXene heterojunction as ferroptosis inducers for stimulating immunogenic cell death against ovarian cancer.
Ferroptosis: First evidence in premature duck ovary induced by polyvinyl chloride microplastics.
An investigation of the distributions of ferroptosis and necroptosis mediators in the maternal-fetal interface at different days of rat pregnancy.
Berberine alleviates contrast-induced nephropathy by activating Akt/Foxo3a/Nrf2 signalling pathway.
Ambra1 in exosomes secreted by HK-2 cells damaged by supersaturated oxalate induce mitophagy and autophagy-ferroptosis in normal HK-2 cells to participate in the occurrence of kidney stones.
KLF6 silencing attenuates MCAO-induced brain injury and cognitive dysfunction via targeting ferroptosis and activating the Nrf2/HO-1 pathway.
Cadmium Induces Kidney Iron Deficiency and Chronic Kidney Injury by Interfering with the Iron Metabolism in Rats.
Targeting PKD2 aggravates ferritinophagy-mediated ferroptosis via promoting autophagosome-lysosome fusion and enhances efficacy of carboplatin in lung adenocarcinoma.
Buddlejasaponin IVb ameliorates ferroptosis of dopaminergic neuron by suppressing IRP2-mediated iron overload in Parkinson's disease.
Multifunctional Fe-based coordination polymer nano-bomb modified with β-lapachone and CaO(2) for targeted tumor dual chemodynamic therapy with enhanced ferroptosis and H(2)O(2) self-supply.
AURKA inhibition induces Ewing's sarcoma apoptosis and ferroptosis through NPM1/YAP1 axis.
Sunitinib induces cardiotoxicity through modulating oxidative stress and Nrf2-dependent ferroptosis in vitro and in vivo.
Bomidin attenuates inflammation of periodontal ligament stem cells and periodontitis in mice via inhibiting ferroptosis.
High-Throughput Sequencing to Investigate the Expression and Potential Role of Differentially Expressed microRNAs in Myocardial Cells after Ischemia-Reperfusion Injury.
α-Ketoglutarate improves cardiac insufficiency through NAD(+)-SIRT1 signaling-mediated mitophagy and ferroptosis in pressure overload-induced mice.
Rapid and comprehensive metabolites identification of 5-demethylnobiletin in rats using UPLC/Triple-TOF-MS/MS based on multiple mass defect filter and their neuroprotection against ferroptosis.
PKCiota Inhibits the Ferroptosis of Esophageal Cancer Cells via Suppressing USP14-Mediated Autophagic Degradation of GPX4.
Hepatic Alterations in a BTBR T + Itpr3tf/J Mouse Model of Autism and Improvement Using Melatonin via Mitigation Oxidative Stress, Inflammation and Ferroptosis.
Heliox Protects SH-SY5Y Cells from Oxygen-Glucose Deprivation/Reperfusion-Induced Ferroptosis.
Resveratrol protected against the development of endometriosis by promoting ferroptosis through miR-21-3p/p53/SLC7A11 signaling pathway.
Hesperetin promotes bladder cancer cells death via the PI3K/AKT pathway by network pharmacology and molecular docking.
Excessive SOX8 reprograms energy and iron metabolism to prime hepatocellular carcinoma for ferroptosis.
Targeting Ferroptosis Promotes Functional Recovery by Mitigating White Matter Injury Following Acute Carbon Monoxide Poisoning.
Integrated analysis and validation of TRIM23/p53 signaling pathway in hepatic stellate cells ferroptosis and liver fibrosis.
Nrf2 protects against cartilage endplate degeneration through inhibiting NCOA4‑mediated ferritinophagy.
SENP1 inhibits ferroptosis and promotes head and neck squamous cell carcinoma by regulating ACSL4 protein stability via SUMO1.
Protective effects of melatonin on DEHP-induced apoptosis and oxidative stress in prepubertal testes via the PI3K/AKT pathway.
Se-(Methyl)-selenocysteine ameliorates blood-brain barrier disruption of focal cerebral ischemia mice via ferroptosis inhibition and tight junction upregulation in an Akt/GSK3β-dependent manner.
Fructus Ligustri Lucidi inhibits ferroptosis in ovariectomy‑induced osteoporosis in rats via the Nrf2/HO‑1 signaling pathway.
WWP2 protects against sepsis-induced cardiac injury through inhibiting cardiomyocyte ferroptosis.
Bile acids inhibit ferroptosis sensitivity through activating farnesoid X receptor in gastric cancer cells.
Inhibiting LCN2 can suppress the development of NSCLC by promoting ferroptosis.
SMG9 is a novel prognostic-related biomarker in glioma correlating with ferroptosis and immune infiltrates.
SKP alleviates the ferroptosis in diabetic kidney disease through suppression of HIF-1α/HO-1 pathway based on network pharmacology analysis and experimental validation.
Inhibition of ferroptosis reverses heart failure with preserved ejection fraction in mice.
Complement components regulates ferroptosis in CVB3 viral myocarditis by interatction with TFRC.
P21 resists ferroptosis in osteoarthritic chondrocytes by regulating GPX4 protein stability.
Pterostilbene attenuates heart failure by inhibiting myocardial ferroptosis through SIRT1/GSK-3β/GPX4 signaling pathway.
Oridonin-induced ferroptosis and apoptosis: a dual approach to suppress the growth of osteosarcoma cells.
1,4-dihydroxy quininib activates ferroptosis pathways in metastatic uveal melanoma and reveals a novel prognostic biomarker signature.
NCF-1 plays a pivotal role in the survival of adenocarcinoma cells of pancreatic and gastric origins.
Apelin deficiency exacerbates cardiac injury following infarction by accelerating cardiomyocyte ferroptosis.
Inhibition of CDGSH iron‑sulfur domain 2 exhibits tumor-suppressing effects on diffuse large B-cell lymphoma (DLBCL) by inducing ferroptosis through the regulation of the NRF2/SLC7A11/GPX4 pathway.
Sirt6 overexpression relieves ferroptosis and delays the progression of diabetic nephropathy via Nrf2/GPX4 pathway.
Identification and validation of protein biomarkers for predicting gastrointestinal stromal tumor recurrence.
The plant extract PNS mitigates atherosclerosis via promoting Nrf2-mediated inhibition of ferroptosis through reducing USP2-mediated Keap1 deubiquitination.
Yanghe Decoction promotes ferroptosis through PPARγ-dependent autophagy to inhibit the malignant progression of triple-negative breast cancer.
Y9, a Gboxin analog, displays anti-tumor effect in non-small cell lung cancer by inducing lysosomal dysfunction and apoptosis.
Ginsenoside compound K alleviates brain aging by inhibiting ferroptosis through modulation of the ASK1-MKK7-JNK signaling pathway.
Naringenin alleviates intestinal ischemia/reperfusion injury by inhibiting ferroptosis via targeting YAP/STAT3 signaling axis.
The Intestinal Transporter SLC30A1 Plays a Critical Role in Regulating Systemic Zinc Homeostasis.
Effects of high-dose selenium-enriched Saccharomyces cerevisiae on growth performance, antioxidant status, tissue fat content and selenium concentration, and selenoenzyme mRNA expression in chicks.
To explore the protective mechanism of promethazine against hippocampal neuron injury based on network pharmacology and experimental verification.
Gypenoside A-loaded mPEG-PLGA nanoparticles ameliorate high-glucose-induced retinal microvasculopathy by inhibiting ferroptosis.
RTA408 alleviates lipopolysaccharide-induced acute lung injury via inhibiting Bach1-mediated ferroptosis.
Simvastatin induces ferroptosis and activates anti-tumor immunity to sensitize anti-PD-1 immunotherapy in microsatellite stable gastric cancer.
OTULIN confers cisplatin resistance in osteosarcoma by mediating GPX4 protein homeostasis to evade the mitochondrial apoptotic pathway.
Apigenin alleviates Sjögren's syndrome-induced salivary gland epithelial cell ferroptosis via ERα signaling-mediated regulation of the ATF3/SLC7A1l axis.
ASIC1a regulates ferroptosis in hepatic stellate cells via the Hippo/Yap-1 pathway in liver fibrosis.
African swine fever virus enhances viral replication by increasing intracellular reduced glutathione levels, which suppresses stress granule formation.
DNMT aberration-incurred GPX4 suppression prompts osteoblast ferroptosis and osteoporosis.
Chemerin attenuates acute kidney injury by inhibiting ferroptosis via the AMPK/NRF2/SLC7A11 axis.
Integrated network pharmacology and transcriptomics to explore the mechanism of compound Dihuang granule (CDG) protects dopaminergic neurons by regulating the Nrf2/HMOX1 pathway in the 6-OHDA/MPP(+)-induced model of Parkinson's disease.
FAM96B negatively regulates FOSL1 to modulate the osteogenic differentiation and regeneration of periodontal ligament stem cells via ferroptosis.
IL-1β-induced mesenchymal stem cell-derived exosomes inhibit neuronal ferroptosis in intracerebral hemorrhage through the HSPA5/GPX4 axis.
Effects of ginger root extract on cognitive impairment and the Nrf2/GPX4/SLC7A11 signaling pathway in aluminum-exposed rats.
Ion channel Piezo1 induces ferroptosis of trabecular meshwork cells: a novel observation in the pathogenesis in primary open angle glaucoma.
Pharmacodynamic insights into maresin 1: Enhancing flap viability via the keap1/Nrf2 axis to control ROS-driven apoptosis and ferroptosis.
A polo-like kinase 1 inhibitor enhances erastin sensitivity in head and neck squamous cell carcinoma cells in vitro.
Ferroptosis is involved in cisplatin sensitivity of the S3 segment of immortalized proximal tubule cells.
Propofol Mitigates Sepsis-Induced Brain Injury by Inhibiting Ferroptosis Via Activation of the Nrf2/HO-1axis.
GOLPH3 inhibits erastin-induced ferroptosis in colorectal cancer cells.
Isobavachalcone induces hepatotoxicity in zebrafish embryos and HepG2 cells via the System Xc(-)-GSH-GPX4 signaling pathway in ferroptosis response.
Curcumin suppresses colorectal cancer by induction of ferroptosis via regulation of p53 and solute carrier family 7 member 11/glutathione/glutathione peroxidase 4 signaling axis.
PRDX6 augments selenium utilization to limit iron toxicity and ferroptosis.
Baicalin protects against hepatocyte injury caused by aflatoxin B(1) via the TP53-related ferroptosis Pathway.
Casticin induces ferroptosis in human osteosarcoma cells through Fe(2+) overload and ROS production mediated by HMOX1 and LC3-NCOA4.
The Deubiquitinase USP22-Stabilized COL17A1 Promotes Lung Adenocarcinoma Progression.
Integrated multi-omics profiling landscape of organising pneumonia.
Exosomes From Muscle-Derived Stem Cells Repair Peripheral Nerve Injury by Inhibiting Ferroptosis via the Keap1-Nrf2-Ho-1 Axis.
The effects of the atrial natriuretic peptide deficiency on renal cortical mitochondrial bioenergetics in the Dahl SS rat.
Effects on Iron Metabolism and System Xc- /GPX4 Pathway from Hydroquinone Suggest Ferroptosis of Jurkat Cells.
Sterigmatocystin declines mouse oocyte quality by inducing ferroptosis and asymmetric division defects.
Recharacterization of RSL3 reveals that the selenoproteome is a druggable target in colorectal cancer.
HO-1 activation contributes to cadmium-induced ferroptosis in renal tubular epithelial cells via increasing the labile iron pool and promoting mitochondrial ROS generation.
Natural Product Auraptene Targets SLC7A11 for Degradation and Induces Hepatocellular Carcinoma Ferroptosis.
Taurine Alleviates Ferroptosis-Induced Metabolic Impairments in C2C12 Myoblasts by Stabilizing the Labile Iron Pool and Improving Redox Homeostasis.
CircEZH2 promotes gallbladder cancer progression and lipid metabolism reprogramming through the miR-556-5p/SCD1 axis.
Tetramethylpyrazine alleviates ferroptosis and promotes functional recovery in spinal cord injury by regulating GPX4/ACSL4.
Exploration and validation of therapeutic molecules for rheumatoid arthritis based on ferroptosis-related genes.
β-Caryophyllene Confers Cardioprotection by Scavenging Radicals and Blocking Ferroptosis.
Autophagy-mediated ferroptosis is involved in development of severe acute pancreatitis.
Human umbilical cord mesenchymal stem cells alleviate chemotherapy-induced premature ovarian insufficiency mouse model by suppressing ferritinophagy-mediated ferroptosis in granulosa cells.
EGCG-NPs inhibition HO-1-mediated reprogram iron metabolism against ferroptosis after subarachnoid hemorrhage.
PRDX6 alleviated heart failure by inhibiting doxorubicin-induced ferroptosis through the JAK2/STAT1 pathway inactivation.
SIRT5 Regulates Ferroptosis through the Nrf2/HO-1 Signaling Axis to Participate in Ischemia-Reperfusion Injury in Ischemic Stroke.
Magnolin alleviated DSS-induced colitis by inhibiting ALOX5-mediated ferroptosis.
Sulfasalazine promotes ferroptosis through AKT-ERK1/2 and P53-SLC7A11 in rheumatoid arthritis.
APE1 inhibition enhances ferroptotic cell death and contributes to hepatocellular carcinoma therapy.
GPX4-mediated bone ferroptosis under mechanical stress decreased bone formation via the YAP-TEAD signalling pathway.
A Pt(II) complex bearing N-heterocycle ring induced ferroptotic cell death in ovarian cancer.
WDR23 mediates NRF2 proteostasis and cytoprotective capacity in the hippocampus.
Copper Exposure Induced Chicken Hepatotoxicity: Involvement of Ferroptosis Mediated by Lipid Peroxidation, Ferritinophagy, and Inhibition of FSP1-CoQ10 and Nrf2/SLC7A11/GPX4 Axis.
Identification and validation of an immunotherapeutic signature for colon cancer based on the regulatory patterns of ferroptosis and their association with the tumor microenvironment.
Co-catalpol alleviates fluoxetine-induced main toxicity: Involvement of ATF3/FSP1 signaling-mediated inhibition of ferroptosis.
Excessive fluoride induces ovarian function impairment by regulating levels of ferroptosis in fluorosis women and ovarian granulosa cells.
A NRF2 Regulated and the Immunosuppressive Microenvironment Reversed Nanoplatform for Cholangiocarcinoma Photodynamic-Gas Therapy.
Chronic Aroclor 1260 exposure alters the mouse liver proteome, selenoproteins, and metals in steatotic liver disease.
PPARγ alleviates preeclampsia development by regulating lipid metabolism and ferroptosis.
Design, synthesis, and evaluation of novel ferrostatin derivatives for the prevention of HG-induced VEC ferroptosis.
Pharmacodynamic and Toxicity Studies of 6-Isopropyldithio-2'-guanosine Analogs in Acute T-Lymphoblastic Leukemia.
Medium-chain chlorinated paraffins (MCCPs) induce renal cell aging and ferroptosis.
ED-71 ameliorates bone regeneration in type 2 diabetes by reducing ferroptosis in osteoblasts via the HIF1α pathway.
Hazel Leaf Polyphenol Extract Alleviated Cisplatin-Induced Acute Kidney Injury by Reducing Ferroptosis through Inhibiting Hippo Signaling.
Detection of Ferroptosis in Patient-Derived Tumor Models.
Pterostilbene Confers Protection against Diquat-Induced Intestinal Damage with Potential Regulation of Redox Status and Ferroptosis in Broiler Chickens.
NF-κB Inhibitor Myrislignan Induces Ferroptosis of Glioblastoma Cells via Regulating Epithelial-Mesenchymal Transformation in a Slug-Dependent Manner.
Curcumin Induces Ferroptosis in Follicular Thyroid Cancer by Upregulating HO-1 Expression.
Vitronectin Destroyed Intestinal Epithelial Cell Differentiation through Activation of PDE4-Mediated Ferroptosis in Inflammatory Bowel Disease.
Timosaponin AIII promotes non-small-cell lung cancer ferroptosis through targeting and facilitating HSP90 mediated GPX4 ubiquitination and degradation.
Inhibition of KMO Ameliorates Myocardial Ischemia Injury via Maintaining Mitochondrial Fusion and Fission Balance.
Sarcoma protein kinase inhibition alleviates liver fibrosis by promoting hepatic stellate cells ferroptosis.
Vancomycin Induced Ferroptosis in Renal Injury Through the Inactivation of Recombinant Glutathione Peroxidase 4 and the Accumulation of Peroxides.
Integrated Analysis of Ferroptosis and Immunity-Related Genes Associated with Diabetic Kidney Disease.
Identification of Novel Targets for Treatment of Dilated Cardiomyopathy Based on the Ferroptosis and Immune Heterogeneity.
Xue-Jie-San restricts ferroptosis in Crohn's disease via inhibiting FGL1/NF-κB/STAT3 positive feedback loop.
Wogonin induces ferroptosis in pancreatic cancer cells by inhibiting the Nrf2/GPX4 axis.
Metabolite Neu5Ac triggers SLC3A2 degradation promoting vascular endothelial ferroptosis and aggravates atherosclerosis progression in ApoE(-/-)mice.
Depletion of PSMD14 suppresses bladder cancer proliferation by regulating GPX4.
Identification of EGFR as an essential regulator in chondrocytes ferroptosis of osteoarthritis using bioinformatics, in vivo, and in vitro study.
Sulforaphane, an NRF2 agonist, alleviates ferroptosis in acute liver failure by regulating HDAC6 activity.
Combination therapy to overcome ferroptosis resistance by biomimetic self-assembly nano-prodrug.
Activation of Nrf2 inhibits ferroptosis and protects against oxaliplatin-induced ototoxicity.
Ozone pretreatment alleviates ischemiareperfusion injury-induced myocardial ferroptosis by activating the Nrf2/Slc7a11/Gpx4 axis.
ACSL4 promotes ferroptosis and M1 macrophage polarization to regulate the tumorigenesis of nasopharyngeal carcinoma.
Small extracellular vesicles from HO-1-modified bone marrow-derived mesenchymal stem cells attenuate ischemia-reperfusion injury after steatotic liver transplantation by suppressing ferroptosis via miR-214-3p.
Metformin induces ferroptosis through the Nrf2/HO-1 signaling in lung cancer.
Cadmium exposure promotes ferroptosis by upregulating Heat Shock Protein 70 in vascular endothelial damage of zebrafish.
Gambogenic acid induces cell death in human osteosarcoma through altering iron metabolism, disturbing the redox balance, and activating the P53 signaling pathway.
An inducible long noncoding RNA, LncZFHX2, facilitates DNA repair to mediate osteoarthritis pathology.
NRF2 Antagonizes HIV-1 Tat and Methamphetamine-Induced BV2 Cell Ferroptosis by Regulating SLC7A11.
Scutellarein alleviates chronic obstructive pulmonary disease through inhibition of ferroptosis by chelating iron and interacting with arachidonate 15-lipoxygenase.
TRAP1 inhibits MARCH5-mediated MIC60 degradation to alleviate mitochondrial dysfunction and apoptosis of cardiomyocytes under diabetic conditions.
Sonodynamic Therapy of NRP2 Monoclonal Antibody-Guided MOFs@COF Targeted Disruption of Mitochondrial and Endoplasmic Reticulum Homeostasis to Induce Autophagy-Dependent Ferroptosis.
Use of Deep-Learning Assisted Assessment of Cardiac Parameters in Zebrafish to Discover Cyanidin Chloride as a Novel Keap1 Inhibitor Against Doxorubicin-Induced Cardiotoxicity.
3β-Hydroxy-12-oleanen-27-oic Acid Exerts an Antiproliferative Effect on Human Colon Carcinoma HCT116 Cells via Targeting FDFT1.
The clinical predictive value and regulation mechanism of microRNA-188-5p in contrast-induced acute kidney injury.
Paeoniae Radix Rubra extract attenuates cerebral ischemia injury by inhibiting ferroptosis and activating autophagy through the PI3K/Akt signalling pathway.
Exogenous H(2)S initiating Nrf2/GPx4/GSH pathway through promoting Syvn1-Keap1 interaction in diabetic hearts.
Targeting ferroptosis attenuates podocytes injury and delays tubulointerstitial fibrosis in focal segmental glomerulosclerosis.
Evodiamine impairs HIF1A histone lactylation to inhibit Sema3A-mediated angiogenesis and PD-L1 by inducing ferroptosis in prostate cancer.
Enriched environment attenuates ferroptosis after cerebral ischemia/reperfusion injury by regulating iron metabolism.
WDR23 mediates NRF2 proteostasis and cytoprotective capacity in the hippocampus.
N-acetylcysteine attenuates the incidence of phlebitis induced by carbomer/vinorelbine gel.
Heme Oxygenase-1-Modified BMMSCs Activate AMPK-Nrf2-FTH1 to Reduce Severe Steatotic Liver Ischemia-Reperfusion Injury.
Acetyl zingerone ameliorates osteoarthritis by inhibiting chondrocyte programmed cell death.
The ferroptosis activity is associated with neurological recovery following chronic compressive spinal cord injury.
The deubiquitinase ZRANB1 is an E3 ubiquitin ligase for SLC7A11 and regulates ferroptotic resistance.
Extracellular vesicle-derived silk fibroin nanoparticles loaded with MFGE8 accelerate skin ulcer healing by targeting the vascular endothelial cells.
Fucoidan Ameliorates Ferroptosis in Ischemia-reperfusion-induced Liver Injury through Nrf2/HO-1/GPX4 Activation.
Phenylarsine oxide induced corneal injury involves oxidative stress mediated unfolded protein response and ferroptotic cell death: Amelioration by NAC.
Activation of the Nrf-2 pathway by pinocembrin safeguards vertebral endplate chondrocytes against apoptosis and degeneration caused by oxidative stress.
Acetyl-CoA Acetyltransferase 2 Confers Radioresistance by Inhibiting Ferroptosis in Esophageal Squamous Cell Carcinoma.
Synergistic ferroptosis-starvation therapy for bladder cancer based on hyaluronic acid modified metal-organic frameworks.
Klotho improves cardiac fibrosis, inflammatory cytokines, ferroptosis, and oxidative stress in mice with myocardial infarction.
MELTF Might Regulate Ferroptosis, Pyroptosis, and Autophagy in Platelet-Rich Plasma-Mediated Endometrial Epithelium Regeneration.
Ambient particulate matter exposure plus chronic ethanol ingestion exacerbates hepatic fibrosis by triggering the mitochondrial ROS-ferroptosis signaling pathway in mice.
CDGSH iron sulfur domain 2 over-expression alleviates neuronal ferroptosis and brain injury by inhibiting lipid peroxidation via AKT/mTOR pathway following intracerebral hemorrhage in mice.
Autophagy inhibition and ferroptosis activation during atherosclerosis: Hypoxia-inducible factor 1α inhibitor PX-478 alleviates atherosclerosis by inducing autophagy and suppressing ferroptosis in macrophages.
An ultrasensitive GSH-specific fluorescent probe unveils celastrol-induced ccRCC ferroptosis.
Polydopamine Nanoparticles Targeting Ferroptosis Mitigate Intervertebral Disc Degeneration Via Reactive Oxygen Species Depletion, Iron Ions Chelation, and GPX4 Ubiquitination Suppression.
Bisphenol A induces testicular oxidative stress in mice leading to ferroptosis.
Rhein Inhibited Ferroptosis and EMT to Attenuate Diabetic Nephropathy by Regulating the Rac1/NOX1/β-Catenin Axis.
DiDang decoction improves mitochondrial function and lipid metabolism via the HIF-1 signaling pathway to treat atherosclerosis and hyperlipidemia.
Epigenetically silenced lncRNA SNAI3-AS1 promotes ferroptosis in glioma via perturbing the m(6)A-dependent recognition of Nrf2 mRNA mediated by SND1.
TRIM21 ubiquitylates GPX4 and promotes ferroptosis to aggravate ischemia/reperfusion-induced acute kidney injury.
Supression Thioredoxin reductase 3 exacerbates the progression of liver cirrhosis via activation of ferroptosis pathway.
Reversal of H(2)O(2)-induced cell death by knockdown of HOTAIR in HTR-8/SVneo cells by mediation of miR-106b-5p/ACSL4 axis.
PM(2.5) caused ferroptosis in spermatocyte via overloading iron and disrupting redox homeostasis.
Liberation of daidzein by gut microbial β-galactosidase suppresses acetaminophen-induced hepatotoxicity in mice.
Hepatocyte ferroptosis contributes to anti-tuberculosis drug-induced liver injury: Involvement of the HIF-1α/SLC7A11/GPx4 axis.
Effects of icariin and curcumol on autophagy, ferroptosis, and lipid metabolism based on miR-7/m-TOR/SREBP1 pathway on prostate cancer.
Uridine Alleviates Sepsis-Induced Acute Lung Injury by Inhibiting Ferroptosis of Macrophage.
HSPA5 Promotes the Proliferation, Metastasis and Regulates Ferroptosis of Bladder Cancer.
A Novel Three-Dimensional Follicle Culture System Decreases Oxidative Stress and Promotes the Prolonged Culture of Human Granulosa Cells.
PTEN inhibitor VO-OHpic protects endplate chondrocytes against apoptosis and calcification via activating Nrf-2 signaling pathway.
Toosendanin induced hepatotoxicity via triggering PERK-eIF2α-ATF4 mediated ferroptosis.
TRIM25 promotes temozolomide resistance in glioma by regulating oxidative stress and ferroptotic cell death via the ubiquitination of keap1.
Employing single valency polyphenol to prepare metal-phenolic network antitumor reagents through FeOOH assistance.
BACH1 promotes intervertebral disc degeneration by regulating HMOX1/GPX4 to mediate oxidative stress, ferroptosis, and lipid metabolism in nucleus pulposus cells.
Astaxanthin suppresses oxidative stress and calcification in vertebral cartilage endplate via activating Nrf-2/HO-1 signaling pathway.
PRMT5 reduces immunotherapy efficacy in triple-negative breast cancer by methylating KEAP1 and inhibiting ferroptosis.
Terpinen-4-ol Induces Ferroptosis of Glioma Cells via Downregulating JUN Proto-Oncogene.
Pien-Tze-Huang prevents hepatocellular carcinoma by inducing ferroptosis via inhibiting SLC7A11-GSH-GPX4 axis.
Dihydroorotate dehydrogenase regulates ferroptosis in neurons after spinal cord injury via the P53-ALOX15 signaling pathway.
SIRT3-mediated autophagy contributes to ferroptosis-induced anticancer by inducing the formation of BECN1-SLC7A11 complex.
Ferrostatin-1 alleviates the damage of C2C12 myoblast and mouse pelvic floor muscle induced by mechanical trauma.
The effect of ferroptosis - related proteins and histone deacetylases1 on neoadjuvant chemotherapy in breast cancer.
SATB1/SLC7A11/HO-1 Axis Ameliorates Ferroptosis in Neuron Cells After Ischemic Stroke by Danhong Injection.
Elabela blunts doxorubicin-induced oxidative stress and ferroptosis in rat aortic adventitial fibroblasts by activating the KLF15/GPX4 signaling.
Dexmedetomidine attenuates airway inflammation and oxidative stress in asthma via the Nrf2 signaling pathway.
A novel 3-phenylglutaric acid derivative (84-B10) alleviates cisplatin-induced acute kidney injury by inhibiting mitochondrial oxidative stress-mediated ferroptosis.
Fibroblast ferroptosis is involved in periodontitis-induced tissue damage and bone loss.
Paeonol ameliorates endometrial hyperplasia in mice via inhibiting PI3K/AKT pathway-related ferroptosis.
Dendrobium Nobile Polysaccharides Attenuates Ferroptosis and Improves Cognitive Function in Vascular Dementia Rats.
Yiqi Chutan Formula Reverses Cisplatin-Induced Apoptosis and Ferroptosis of Skeletal Muscle by Alleviating Oxidative Stress.
Hyperforin Elicits Cytostatic/Cytotoxic Activity in Human Melanoma Cell Lines, Inhibiting Pro-Survival NF-κB, STAT3, AP1 Transcription Factors and the Expression of Functional Proteins Involved in Mitochondrial and Cytosolic Metabolism.
SGK2 promotes prostate cancer metastasis by inhibiting ferroptosis via upregulating GPX4.
Qing-Xin-Jie-Yu Granule inhibits ferroptosis and stabilizes atherosclerotic plaques by regulating the GPX4/xCT signaling pathway.
Berberine hydrochloride alleviates imatinib mesylate - induced cardiotoxicity through the inhibition of Nrf2-dependent ferroptosis.
The natural flavone acacetin protects against high-fat diet-induced lipid accumulation in the liver via the endoplasmic reticulum stress/ferroptosis pathway.
Lipocalin 2 induces visual impairment by promoting ferroptosis in retinal ischemia-reperfusion injury.
Effects of ferroptosis in myocardial ischemia/reperfusion model of rat and its association with Sestrin 1.
Glutathione ameliorates the meiotic defects of copper exposed ovine oocytes via inhibiting the mitochondrial dysfunctions.
Triterpenoids from Uncaria macrophylla as ferroptosis inhibitors.
Transcriptome analysis highlights the role of ferroptosis in palmitic acid-induced endothelial dysfunction.
Neurotoxic A1 astrocytes promote neuronal ferroptosis via CXCL10/CXCR3 axis in epilepsy.
The SIRT3 activator ganoderic acid D regulates airway mucin MUC5AC expression via the NRF2/GPX4 pathway.
Mesenchymal stem cells-derived exosomes ameliorate high glucose and lipopolysaccharide-induced HPMECs injury through the Nrf2/HO-1 pathway.
Curcumin strengthens a spontaneous self-protective mechanism-SP1/PRDX6 pathway, against di-n-butyl phthalate-induced testicular ferroptosis damage.
Xanthohumol attenuates renal ischemia/reperfusion injury by inhibiting ferroptosis.
PUFAs add fuel to Crohn's disease-associated AIEC-induced enteritis by exacerbating intestinal epithelial lipid peroxidation.
Eicosapentaenoic acid enhances the sensitivity of osteosarcoma to cisplatin by inducing ferroptosis through the DNA-PKcs/AKT/NRF2 pathway and reducing PD-L1 expression to attenuate immune evasion.
β-aminoisobutyrics acid, a metabolite of BCAA, activates the AMPK/Nrf-2 pathway to prevent ferroptosis and ameliorates lung ischemia-reperfusion injury.
Imatinib induces ferroptosis in gastrointestinal stromal tumors by promoting STUB1-mediated GPX4 ubiquitination.
Overexpression of FSP1 Ameliorates ferroptosis via PI3K/ AKT /GSK3β pathway in PC12 cells with Oxygen-Glucose Deprivation/Reoxygenation.
A potent phosphodiester Keap1-Nrf2 protein-protein interaction inhibitor as the efficient treatment of Alzheimer's disease.
Effect of P53 nuclear localization mediated by G3BP1 on ferroptosis in acute liver failure.
Role of Escin in breast cancer therapy: potential mechanism for inducing ferroptosis and synergistic antitumor activity with cisplatin.
ETS1 Ameliorates Hyperoxia-Induced Bronchopulmonary Dysplasia in Mice by Activating Nrf2/HO-1 Mediated Ferroptosis.
Gegen Qinlian decoction (GQD) inhibits ulcerative colitis by modulating ferroptosis-dependent pathway in mice and organoids.
Ficolin B secreted by alveolar macrophage exosomes exacerbates bleomycin-induced lung injury via ferroptosis through the cGAS-STING signaling pathway.
MEN1 is a regulator of alternative splicing and prevents R-loop-induced genome instability through suppression of RNA polymerase II elongation.
CXCL8 Promotes Endothelial-to-Mesenchymal Transition of Endothelial Cells and Protects Cells from Erastin-Induced Ferroptosis via CXCR2-Mediated Activation of the NF-κB Signaling Pathway.
Knockdown of SETD2 promotes erastin-induced ferroptosis in ccRCC.
Overexpression of GPX4 attenuates cognitive dysfunction through inhibiting hippocampus ferroptosis and neuroinflammation after traumatic brain injury.
Targeting the Na(+)/K(+) ATPase DR-region with DR-Ab improves doxorubicin-induced cardiotoxicity.
Ketogenic diet alleviates brain iron deposition and cognitive dysfunction via Nrf2-mediated ferroptosis pathway in APP/PS1 mouse.
Erythropoietin inhibits ferroptosis and ameliorates neurological function after spinal cord injury.
Matrine alleviates oxidative stress and ferroptosis in severe acute pancreatitis-induced acute lung injury by activating the UCP2/SIRT3/PGC1α pathway.
Water extract from Herpetospermum pedunculosum attenuates oxidative stress and ferroptosis induced by acetaminophen via regulating Nrf2 and NF-κB pathways.
Combination treatment with FAAH inhibitors/URB597 and ferroptosis inducers significantly decreases the growth and metastasis of renal cell carcinoma cells via the PI3K-AKT signaling pathway.
Butyrate dictates ferroptosis sensitivity through FFAR2-mTOR signaling.
Glucose Starvation Inhibits Ferroptosis by Activating the LKB1/AMPK Signaling Pathway and Promotes the High Speed Linear Motility of Dairy Goat Sperm.
Ginsenoside Rh3 induces pyroptosis and ferroptosis through the Stat3/p53/NRF2 axis in colorectal cancer cells.
Mitoglitazone ameliorates renal ischemia/reperfusion injury by inhibiting ferroptosis via targeting mitoNEET.
Ferroptosis mediates decabromodiphenyl ether-induced liver damage and inflammation.
Hydrogen Sulfide Inhibits Ferroptosis in Cardiomyocytes to Protect Cardiac Function in Aging Rats.
Edaravone Ameliorates Cerebral Ischemia-Reperfusion Injury by Downregulating Ferroptosis via the Nrf2/FPN Pathway in Rats.
Effect of one-time high load exercise on skeletal muscle injury in rats of different genders: oxidative stress and mitochondrial responses.
Attenuation by Time-Restricted Feeding of High-Fat and High-Fructose Diet-Induced NASH in Mice Is Related to Per2 and Ferroptosis.
Cryptotanshinone Protects against PCOS-Induced Damage of Ovarian Tissue via Regulating Oxidative Stress, Mitochondrial Membrane Potential, Inflammation, and Apoptosis via Regulating Ferroptosis.
TUG1/MAZ/FTH1 Axis Attenuates the Antiglioma Effect of Dihydroartemisinin by Inhibiting Ferroptosis.
miR-29a-3p in Exosomes from Heme Oxygenase-1 Modified Bone Marrow Mesenchymal Stem Cells Alleviates Steatotic Liver Ischemia-Reperfusion Injury in Rats by Suppressing Ferroptosis via Iron Responsive Element Binding Protein 2.
miR-127-5p Targets JAM3 to Regulate Ferroptosis, Proliferation, and Metastasis in Malignant Meningioma Cells.
Ginsenoside Rh4 Inhibits Colorectal Cancer Cell Proliferation by Inducing Ferroptosis via Autophagy Activation.
Melatonin Alleviates Acute Kidney Injury by Inhibiting NRF2/Slc7a11 Axis-Mediated Ferroptosis.
Atorvastatin Inhibits Ferroptosis of H9C2 Cells by regulatingSMAD7/Hepcidin Expression to Improve Ischemia-Reperfusion Injury.
SLC7A11/GPX4 Inactivation-Mediated Ferroptosis Contributes to the Pathogenesis of Triptolide-Induced Cardiotoxicity.
Artemether attenuates renal tubular injury by regulating iron metabolism in mice with streptozotocin-induced diabetes.
Icariin protects vertebral endplate chondrocytes against apoptosis and degeneration via activating Nrf-2/HO-1 pathway.
Targeting Mitochondrial ROS-Mediated Ferroptosis by Quercetin Alleviates High-Fat Diet-Induced Hepatic Lipotoxicity.
Silenced LINC01134 Enhances Oxaliplatin Sensitivity by Facilitating Ferroptosis Through GPX4 in Hepatocarcinoma.
Glutathione Peroxidase 4 as a Therapeutic Target for Anti-Colorectal Cancer Drug-Tolerant Persister Cells.
Designer Exosomes for Targeted Delivery of a Novel Therapeutic Cargo to Enhance Sorafenib-Mediated Ferroptosis in Hepatocellular Carcinoma.
FNDC5 Causes Resistance to Sorafenib by Activating the PI3K/Akt/Nrf2 Pathway in Hepatocellular Carcinoma Cells.
PLA2G6 Silencing Suppresses Melanoma Progression and Affects Ferroptosis Revealed by Quantitative Proteomics.
UFL1 alleviates ER stress and apoptosis stimulated by LPS via blocking the ferroptosis pathway in human granulosa-like cells.
Iron overload promotes intervertebral disc degeneration via inducing oxidative stress and ferroptosis in endplate chondrocytes.
Hedyotis diffusa injection induces ferroptosis via the Bax/Bcl2/VDAC2/3 axis in lung adenocarcinoma.
Dexmedetomidine prevents hemorrhagic brain injury by reducing damage induced by ferroptosis in mice.
Gastrodin Ameliorates Cognitive Dysfunction in Vascular Dementia Rats by Suppressing Ferroptosis via the Regulation of the Nrf2/Keap1-GPx4 Signaling Pathway.
IDH1 Promotes Foam Cell Formation by Aggravating Macrophage Ferroptosis.
Elaiophylin triggers paraptosis and preferentially kills ovarian cancer drug-resistant cells by inducing MAPK hyperactivation.
MCTR1 inhibits ferroptosis by promoting NRF2 expression to attenuate hepatic ischemia-reperfusion injury.
New Deferric Amine Compounds Efficiently Chelate Excess Iron to Treat Iron Overload Disorders and to Prevent Ferroptosis.
Hydrogen Peroxide Promotes the Production of Radiation-Derived EVs Containing Mitochondrial Proteins.
Matrix stiffness-dependent STEAP3 coordinated with PD-L2 identify tumor responding to sorafenib treatment in hepatocellular carcinoma.
Identification of FDFT1 as a potential biomarker associated with ferroptosis in ccRCC.
Cadmium induces ferroptosis mediated inflammation by activating Gpx4/Ager/p65 axis in pancreatic β-cells.
Sirtuin 7 mitigates renal ferroptosis, fibrosis and injury in hypertensive mice by facilitating the KLF15/Nrf2 signaling.
Validation of MAPK signalling pathway as a key role of paeoniflorin in the treatment of intrahepatic cholestasis of pregnancy based on network pharmacology and metabolomics.
A multi-target directed ligands strategy for the treatment of Alzheimer's disease: Dimethyl fumarate plus Tranilast modified Dithiocarbate as AChE inhibitor and Nrf2 activator.
Identification of GPX4 as a therapeutic target for lung adenocarcinoma after EGFR-TKI resistance.
β-amyloid protein induces mitophagy-dependent ferroptosis through the CD36/PINK/PARKIN pathway leading to blood-brain barrier destruction in Alzheimer's disease.
Ferritinophagy is Involved in Experimental Subarachnoid Hemorrhage-Induced Neuronal Ferroptosis.
Elabela alleviates ferroptosis, myocardial remodeling, fibrosis and heart dysfunction in hypertensive mice by modulating the IL-6/STAT3/GPX4 signaling.
Obacunone alleviates ferroptosis during lipopolysaccharide-induced acute lung injury by upregulating Nrf2-dependent antioxidant responses.
SSBP1 drives high fructose-induced glomerular podocyte ferroptosis via activating DNA-PK/p53 pathway.
Notch3 regulates ferroptosis via ROS-induced lipid peroxidation in NSCLC cells.
Metformin alleviates osteoarthritis in mice by inhibiting chondrocyte ferroptosis and improving subchondral osteosclerosis and angiogenesis.
Puerarin Attenuates Oxidative Stress and Ferroptosis via AMPK/PGC1α/Nrf2 Pathway after Subarachnoid Hemorrhage in Rats.
Inhibition of AKT induces p53/SIRT6/PARP1-dependent parthanatos to suppress tumor growth.
Role of ferroptosis-related genes in coronary atherosclerosis and identification of key genes: integration of bioinformatics analysis and experimental validation.
Seco-Lupane Triterpene Derivatives Induce Ferroptosis through GPX4/ACSL4 Axis and Target Cyclin D1 to Block the Cell Cycle.
Glutathione-depleting polymer delivering chlorin e6 for enhancing photodynamic therapy.
TFRC upregulation promotes ferroptosis in CVB3 infection via nucleus recruitment of Sp1.
Dihydroartemisinin enhances the inhibitory effect of sorafenib on HepG2 cells by inducing ferroptosis and inhibiting energy metabolism.
Effects of butein on human osteosarcoma cell proliferation, apoptosis, and autophagy through oxidative stress.
Insamgobonhwan Protects Neuronal Cells from Lipid ROS and Improves Deficient Cognitive Function.
APR-246 induces early cell death by ferroptosis in acute myeloid leukemia.
A biomimetic nanodrug self-assembled from small molecules for enhanced ferroptosis therapy.
Ferroptosis as a mechanism of oligodendrocyte loss and demyelination in experimental autoimmune encephalomyelitis.
RSL3 triggers glioma stem cell differentiation via the Tgm2/AKT/ID1 signaling axis.
Liproxstatin-1 alleviates LPS/IL-13-induced bronchial epithelial cell injury and neutrophilic asthma in mice by inhibiting ferroptosis.
The mechanism of the imbalance between proliferation and ferroptosis in pulmonary artery smooth muscle cells based on the activation of SLC7A11.
Comprehensive analysis of placental gene-expression profiles and identification of EGFR-mediated autophagy and ferroptosis suppression in intrahepatic cholestasis of pregnancy.
Inhibition of the PIN1-NRF2/GPX4 axis imparts sensitivity to cisplatin in cervical cancer cells.
Maresin1 Suppresses High-Glucose-Induced Ferroptosis in Osteoblasts via NRF2 Activation in Type 2 Diabetic Osteoporosis.
GPX4 suppresses ferroptosis to promote malignant progression of endometrial carcinoma via transcriptional activation by ELK1.
Melatonin ameliorates diabetic hyperglycaemia-induced impairment of Leydig cell steroidogenic function through activation of SIRT1 pathway.
Phyto-sesquiterpene lactones DET and DETD-35 induce ferroptosis in vemurafenib sensitive and resistant melanoma via GPX4 inhibition and metabolic reprogramming.
Dexamethasone induces ferroptosis via P53/SLC7A11/GPX4 pathway in glucocorticoid-induced osteonecrosis of the femoral head.
Silencing of lncRNA MALAT1 facilitates erastin-induced ferroptosis in endometriosis through miR-145-5p/MUC1 signaling.
Ferritinophagy-Mediated ROS Production Contributed to Proliferation Inhibition, Apoptosis, and Ferroptosis Induction in Action of Mechanism of 2-Pyridylhydrazone Dithiocarbamate Acetate.
Ferritinophagic Flux Was a Driving Force in Determination of Status of EMT, Ferroptosis, and NDRG1 Activation in Action of Mechanism of 2-Pyridylhydrazone Dithiocarbamate S-Acetic Acid.
Calorie Restriction Protects against Contrast-Induced Nephropathy via SIRT1/GPX4 Activation.
Mesenchymal Stem Cells Alleviate Post-resuscitation Cardiac and Cerebral Injuries by Inhibiting Cell Pyroptosis and Ferroptosis in a Swine Model of Cardiac Arrest.
Characterization of Interplay Between Autophagy and Ferroptosis and Their Synergistical Roles on Manipulating Immunological Tumor Microenvironment in Squamous Cell Carcinomas.
Inhibition of DNMT-1 alleviates ferroptosis through NCOA4 mediated ferritinophagy during diabetes myocardial ischemia/reperfusion injury.
Activation of NRF2/FPN1 pathway attenuates myocardial ischemia-reperfusion injury in diabetic rats by regulating iron homeostasis and ferroptosis.
Lipoxin A4 protects primary spinal cord neurons from Erastin-induced ferroptosis by activating the Akt/Nrf2/HO-1 signaling pathway.
Knockdown of Trnau1ap inhibits the proliferation and migration of NIH3T3, JEG-3 and Bewo cells via the PI3K/Akt signaling pathway.
Zhang L, Luo F, Chai Y, Sun L, Wang X, Yin L, Luo C
PloS one 2026;21(2):e0342335
PloS one 2026;21(2):e0342335
Exosomal lncRNA FENDRR Orchestrates Immune Remodelling and Ferroptosis in the Comorbidity of Lung Cancer and Type 1 Myocardial Infarction.
He Y, Qian Y, Zheng Z, Zhou Y, Li C, Wu Q, Ren M
Human mutation 2026;2026:8861747
Human mutation 2026;2026:8861747
Aloperine Induces Ferroptosis of Colorectal Cancer Cells via the Nrf2 Pathway.
An J, Tian L, Wang R, Ma D, Song J, Yuan R, Wu J, Bu Y, Wang J
OncoTargets and therapy 2026;19:575500
OncoTargets and therapy 2026;19:575500
Actinidia chinensis Planch Root extracts trigger ferroptosis in colorectal cancer via the p53/SLC7A11/GPX4 axis.
Ma C, Chen R, Wang H, Qiu K, Xia Q, Yang S, Wang J, Cheng Z, Cui W, Lu J, Duan S
Frontiers in pharmacology 2026;17:1724983
Frontiers in pharmacology 2026;17:1724983
The contribution of ferroptosis to the epithelial-mesenchymal transition phenotype in models of age-related macular degeneration.
Yang X, Xu W, Xie H, Guo X, Zhu F, Xing Y, Chen C
Frontiers in cell and developmental biology 2026;14:1718715
Frontiers in cell and developmental biology 2026;14:1718715
Identification of potential ferroptosis-related biomarkers in proliferative vitreoretinopathy based on machine learning.
Liu J, Zhang S, Wu L, Xue Y, Liu B, Song H, Xu Q
Frontiers in molecular biosciences 2026;13:1725407
Frontiers in molecular biosciences 2026;13:1725407
Monitoring early micro-oxidation under refrigeration: iron and oxidative markers predict quality loss in grass carp.
Xiong X, Feng R, Zhang H, Ding N, Zhuang S, Tan Y, Ma H, Hong H, Luo Y
Current research in food science 2026;12:101307
Current research in food science 2026;12:101307
Self-amplifying nanomedicine reprograms redox metabolism to trigger immunogenic ferroptosis in colon cancer: multiomics identifies AMPD3 as a novel regulator.
Huang X, Wang L, Guan Q, Chen L, Qi H, Wang H, Qian Y, Song D, Hui Q, Yu H, Wei M, Zheng W, Li Z
Biomaterials 2026 Oct;333:124196
Biomaterials 2026 Oct;333:124196
Genetically engineered Escherichia coli Nissle 1917 enabling on-site melanin synthesis attenuates radiation enteritis through ferroptosis inhibition and gut microbiota modulation.
Lv C, Li H, Li X, Shi W, Li W, Li Z, Hu X, Liu X, Ai Y, Wen Z, Liu F, Ru Y, Xiao H, Li J, Chen X, Liu K
Redox biology 2026 May;92:104141
Redox biology 2026 May;92:104141
Cysteine imaging reveals early redox dysregulation and identifies gnetol as a ferroptosis-modulating agent in doxorubicin cardiotoxicity.
Chen Y, Zhang B, Wei Y, Dai Y, Zhang B, Li J, Wu KJ, Sun N, Shao C
Redox biology 2026 May;92:104131
Redox biology 2026 May;92:104131
Processed phellodendri Chinensis cortex attenuates diabetic nephropathy via ferroptosis inhibition through GPX4/SLC7A11/Nrf2/HO-1 signaling pathway.
Zhou Y, Xu G, Ren W, Chen Y, Jiang S, Zhang S, Ge X, Gao H, Zhang F
Journal of natural medicines 2026 May;80(3):776-796
Journal of natural medicines 2026 May;80(3):776-796
Regulation of sepsis-associated acute kidney injury by ELAVL1 through USP14/NCOA4-mediated ferroptosis in renal tubular epithelial cells.
Zhu X, Zheng P, Jin H, Zhao Q, Kong K, Zheng L, Huang X, Zheng M
Molecular and cellular biochemistry 2026 May;481(5):2253-2266
Molecular and cellular biochemistry 2026 May;481(5):2253-2266
Trimethyltin chloride triggers ferroptosis in myocardial injury: mitochondria-dependent protection by luteolin.
Wang P, Zhang X, Ding N, Liu A, Zhang S, Song Y, Yang L, He H, Chen M, Guo X, Zhang Y
Environment international 2026 May;211:110262
Environment international 2026 May;211:110262
Multi-omics reveals that 4'-O-β-D-glucosyl-5-O-methylvisamminol ameliorates acute liver injury by modulating the miR-30e-3p/Tfrc axis and a multi-dimensional network of ferroptosis, inflammation, metabolism, and gut microbiota.
Zhang T, Zou R, Chen Z, Li Y, Sun X, Sun X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 May;154:158022
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 May;154:158022
Ubiquitin-Specific Protease 45 Inhibits Lung Adenocarcinoma Ferroptosis by Regulating Ubiquitination and Stability of Glutathione Peroxidase 4.
Huang M, Fang M, Wang Y, Liu S, Li F
Cancer medicine 2026 May;15(5):e71901
Cancer medicine 2026 May;15(5):e71901
A Blood-Triggered Adhesive Hydrogel Loaded with Reactive Oxygen Species-Responsive Liposomes for the Treatment of Acute Kidney Injury.
Wang J, Feng J, Li H, Chang X, Chen W, Lai D, Bi Q, Zhao X, Xuan Y, Ye J, Li X, Li Y, Shen D, Ma X
ACS nano 2026 May 5;20(17):12859-12877
ACS nano 2026 May 5;20(17):12859-12877
NUP62 promotes breast cancer progression and inhibits ferroptosis by stabilizing NRF2 in a KEAP1-dependent way.
Qiu Z, Lin Y, Chen S, Cao W, Yang J, Li R, Chen Y, Yao X, Fu S, Jin N
iScience 2026 May 15;29(5):115484
iScience 2026 May 15;29(5):115484
Glutathione metabolic reprogramming by ferroptosis inducers potentiates cuproptosis and antitumor immunity in osteosarcoma.
Xu S, Zhao Y, Yao J, Chen H, Lyu J, Ding Y, Zeng H, Chen H, Hu C, Zhao C
International immunopharmacology 2026 May 15;177:116495
International immunopharmacology 2026 May 15;177:116495
Novel Dual-Pharmacophore TrxR Inhibitors Integrating Ferroptosis and Antitumor Immunity: A Closed-Loop Strategy for TIME Remodeling.
Xu Z, Yang Z, Lv L, Yang J, Liu W
Journal of medicinal chemistry 2026 May 14;69(9):10811-10827
Journal of medicinal chemistry 2026 May 14;69(9):10811-10827
In situ delivery of JPH203 via camptothecin-peptide conjugate nanoassemblies to trigger ferroptosis in triple-negative breast cancer.
Zhang W, Chen L, Dong Y, Zeng Y, Chen Y, Liu Y, Wang J, Shi F
Journal of controlled release : official journal of the Controlled Release Society 2026 May 10;393:114829
Journal of controlled release : official journal of the Controlled Release Society 2026 May 10;393:114829
Squalene epoxidase promotes paraquat-induced pulmonary toxicity through endoplasmic reticulum-mediated ferroptosis.
Zhu Y, Zhao W, Li W, Wang J, Chen H, Wang Z, Wang X, Chen X
Journal of advanced research 2026 Mar;81:673-687
Journal of advanced research 2026 Mar;81:673-687
ENO1 inhibition synergizes with chidamide to induce ferroptosis in PTCL-NOS through metabolic remodeling.
Zhu F, Tian M, Lu K, Wang C, Liu J, Li X, Gu X, Lv B, Huang Z, Zeng L, Li Z, Lu H, Xu K
Blood science (Baltimore, Md.) 2026 Mar;8(1):e00272
Blood science (Baltimore, Md.) 2026 Mar;8(1):e00272
EGR1 promotes ferroptosis in endometriosis through transcriptional activation of HMOX1.
Yang F, Liu D, Hu L, Tan H, Wei Y, Yang R, Huang B, Zou Q, Wu Q, He Y, Mai H, Lan X, Yan Y, Huang Z, Huang X, Fu Z, Deng Z, Huang Q, Yao S, Liang Y
Molecular and cellular endocrinology 2026 Mar;613:112721
Molecular and cellular endocrinology 2026 Mar;613:112721
Concurrent Ferroptosis and Apoptosis in Resveratrol-Treated Glioblastoma Cells: Relevance With NRF2 Downregulation and Oxidative Stress.
Farman A, Zheng X, Wu ML, Hong L, Qian W, Liu J
Cell biology international 2026 Mar;50(3):e70153
Cell biology international 2026 Mar;50(3):e70153
Artemisiae Scopariae Herba (Yinchen) suppresses ferroptosis in mice with osteoporosis via the Nrf2/Slc7a11/Gpx4 pathway
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Li P, Wan X, Li W, Cheng D, Yang Y, Wang Y, Zhu R, Chen Y, Liu H, Zhang Z
Molecular medicine reports 2026 Mar;33(3)
Molecular medicine reports 2026 Mar;33(3)
A multifunctional hydrogel promotes diabetic wound healing by remodeling iron balance and energy metabolism.
Jin C, Lin YZ, Zhang RY, Zhang DP, Xue KK, Xu J, Jiang XQ, Han LJ, Liu LY, Shi YF, Jin MQ, Miu JS, Lu YF, Cai LY, Lin Z, Yang L, Xiao J
Biomaterials 2026 Mar;326:123640
Biomaterials 2026 Mar;326:123640
c-MAF Transcriptionally Activates Slc40a1 to Repress Ferroptosis in Sepsis-Associated Encephalopathy.
Song W, Shen Q, Zhang H, Bu X, Gao W, Wang W
CNS neuroscience & therapeutics 2026 Mar;32(3):e70820
CNS neuroscience & therapeutics 2026 Mar;32(3):e70820
Acceleration of Lactate Uptake and Utilization Contributes to Neuroprotective Action of FGF21 Involved in Naturally Aging Mice.
Ji K, Wei H, Wang R, Wu Y, Li C, Gao H, Zhao L
Aging cell 2026 Mar;25(3):e70423
Aging cell 2026 Mar;25(3):e70423
Rhein-Emodin Combination Activates UQCRC1 to Attenuate MPP(+)-Induced Ferroptosis in Dopaminergic Neurons.
Yusun A, Wan H, Li S, Liu Y, Chen H, Sun M, Ding X, Zhang C
Chemistry & biodiversity 2026 Mar;23(3):e02053
Chemistry & biodiversity 2026 Mar;23(3):e02053
M2 macrophage-derived exosome nanoplatform for targeted H(2)S delivery to alleviate hepatic ischemia-reperfusion injury via synergistic anti-oxidative, anti-inflammatory, and anti-ferroptotic effects.
Zuo T, Shi C, Li J, Li D, Luo X, Xu M, Su M, Lu H, Zhang Y, Hu X, Zhou Q, Shubhra QTH, He X, Cai X
Acta biomaterialia 2026 Mar;212:593-612
Acta biomaterialia 2026 Mar;212:593-612
Apatinib and silver nanoparticles synergize against gastric cancer through the PI3K/Akt signaling pathway-mediated ferroptosis.
Lin Z, Deng Z, Liang J, Chen B, Huang Y, Liu B, Zhao Y
Journal of pharmaceutical analysis 2026 Mar;16(3):101400
Journal of pharmaceutical analysis 2026 Mar;16(3):101400
Astaxanthin alleviates DSS-induced ulcerative colitis in mice associated with Nrf2-mediated ferroptosis independently of gut microbiota modulation.
Wei MX, Wu XY, Lin JW, Huang JY, Cheng J, Huang WF, Xu GH, Yi LT
The Journal of nutritional biochemistry 2026 Mar;149:110212
The Journal of nutritional biochemistry 2026 Mar;149:110212
L-theanine alleviates muscle oxidative damage by improving mitochondrial function, maintaining calcium homeostasis, and inhibiting ferroptosis.
Huang Y, Huang Z, Jia G, Zhao H, Chen X
The Journal of nutritional biochemistry 2026 Mar;149:110182
The Journal of nutritional biochemistry 2026 Mar;149:110182
Copper-induced duodenal injury: Unveiling the dual role of cuproptosis and ferroptosis via the FDX1/GPX4 axis.
Zhang T, Dai X, Wang H, Hu Y, Gao X, Shu X, Cao H, Hu G, Xing C, Yang F
The Journal of nutritional biochemistry 2026 Mar;149:110181
The Journal of nutritional biochemistry 2026 Mar;149:110181
Mast Cell-Derived CXCL4: A Key Mediator of Ferroptosis and Cardiac Damage in Septic Cardiomyopathy.
Wei J, Jiang ZY, Ye LF, Lu HX
Immunity, inflammation and disease 2026 Mar;14(3):e70359
Immunity, inflammation and disease 2026 Mar;14(3):e70359
M6A reader IGF2BP3 stabili1zes SLC7A11 to antagonize ferroptosis and promote gastric tumorigenesis.
Yang Y, Ye H, Qin S, Lin M, Liu Y, Li X
Cellular signalling 2026 Mar;139:112295
Cellular signalling 2026 Mar;139:112295
Quercetin-4'-O-β-D-glucopyranoside inhibits ferroptosis though SIRT5-mediated desuccinylation of TFR1 in diabetic nephropathy.
Wu M, Ye W, Ye X
Scientific reports 2026 Mar 6;16(1)
Scientific reports 2026 Mar 6;16(1)
RRM2/GCH1 signaling decreased cisplatin sensitivity in cervical cancer by modulating the ferroptosis process.
Zhao J, Wang L, Shao N, Qu Y, Chen W, Sun H
Histology and histopathology 2026 Mar 6;:25056
Histology and histopathology 2026 Mar 6;:25056
Trolline attenuates diabetic vascular injury by regulating SLC7A11-mediated ferroptosis and mitochondrial dysfunction.
Liu W, Lu C, Yang B, Liu Y, Yan J, Song T, Wang X
Gene 2026 Mar 5;981:149968
Gene 2026 Mar 5;981:149968
Curcumin protects against difenoconazole-induced kidney injury in carp by inhibiting ferroptosis through the Nrf2/GPX4 axis.
Zhang S, Li X, Gao Y, Dong Q, Jin X, Shi P, Dong J
Fish physiology and biochemistry 2026 Mar 5;52(2)
Fish physiology and biochemistry 2026 Mar 5;52(2)
Polystyrene Nanoplastics induced placental toxicology by activating Keap1-mediated ferroptosis via METTL3-dependent m6A methylation.
Chen Y, Liu Y, Zhang M, Li S, Yan Y, Yin C
Cell biology and toxicology 2026 Mar 3;42(1)
Cell biology and toxicology 2026 Mar 3;42(1)
Cofilin-1 Exacerbates Tau-Induced Mitochondrial Damage, Oxidative Stress, and Apoptosis in Alzheimer's Disease.
Chen Y, Zhang D, Zhang Q, Li Q, Yan D, Qin H, Xiong Y, Zhang C, Wan Y, Yan M
Neurochemical research 2026 Mar 25;51(2)
Neurochemical research 2026 Mar 25;51(2)
A new candidate tumor suppressor tRF-Ser inhibits gastric cancer progression by regulating the CNBP/HSPA8 axis.
Jiao J, Wang G, Liu J, Xiao K, Gao Z, Dong D, Shan K, Cui H, Shang L, Li L, Zhang C
Cell death & disease 2026 Mar 25;17(1)
Cell death & disease 2026 Mar 25;17(1)
[Different Astragalus medicinal pairs improve diabetic nephropathy in mice by regulating lipid peroxidation through PTGS2].
Chen X, Jing Y, Liang H, Zhong J, Chen Z, Peng Y, Dai J, Xiao Y
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2026 Mar 20;46(3):592-603
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2026 Mar 20;46(3):592-603
Mechanistic Study of HDAC6 Regulation of Iron Death in Ulcerative Colitis.
Song JQ, Chen HX, Liu J, Wang YF, Yang ZW
Biological trace element research 2026 Mar 20;
Biological trace element research 2026 Mar 20;
Disruption of iron homeostasis by HERC2-FTL axis leads to chondrocyte loss and exacerbates osteoarthritis.
Zhong Y, Duan J, Chen Z, Ye W, Cai W, Wu R, Mao X, Dai X, Dou P
Apoptosis : an international journal on programmed cell death 2026 Mar 19;31(3)
Apoptosis : an international journal on programmed cell death 2026 Mar 19;31(3)
Liproxstatin-1 Attenuates Retinal Ischemia-Reperfusion Injury by Suppressing EGR1-Mediated Ferroptosis.
Huang W, Dong Y, Zhou X, Lin H, Yao J, Wu Z, Tam WI, Tan Y, Zuo C, Lin M
Antioxidants (Basel, Switzerland) 2026 Mar 19;15(3)
Antioxidants (Basel, Switzerland) 2026 Mar 19;15(3)
Omics insights into MYBL2-promoted cancer stem-like cells driving ferroptosis resistance in hepatocellular carcinoma.
Chen Y, Li X, Luo C, Lin G, Zhou X, Wen Z, Su H, Meng W, Chen C, Lu J, Luo X, Jiang D, Liu H, Ning Z, Chen Y, Tam PK, Pan X
Journal of advanced research 2026 Mar 19;
Journal of advanced research 2026 Mar 19;
IRX4204 sensitizes multiple myeloma to ferroptosis and improves lenalidomide efficacy through the HMOX1-GPX4 axis.
Wu J, Yan Z, Burcher K, Han Z, Nikiforov MA, Vuligonda V, Sanders M, Kang Y
Scientific reports 2026 Mar 17;16(1)
Scientific reports 2026 Mar 17;16(1)
Ginsenoside Rh4 Triggers Ferroptosis in Lung Cancer: Targeting KEAP1/NRF2/HO-1 and Remodeling Gut Microbiota for Butyrate-Mediated ATF3 Activation.
Zhu Q, Xu W, Yang G, Gao Y, Zhao Y, Zhao Z, Kang Y, Li S, Zhao L
International journal of molecular sciences 2026 Mar 16;27(6)
International journal of molecular sciences 2026 Mar 16;27(6)
Microneedle patches deliver targeted GLP-1RAs-loaded nanoparticles for the treatment of rheumatoid arthritis.
Zhang H, Liu Y, Zhang S, Wang Z, Zhang X, Zhang Y, Zhang J, Liang S, Li C, Su M, Tian Z, Luo L
Journal of nanobiotechnology 2026 Mar 16;24(1)
Journal of nanobiotechnology 2026 Mar 16;24(1)
HMGB1-mediated enhancement of glycolysis activates hepatic stellate cells by inhibiting ferroptosis in alcoholic hepatic fibrosis.
Li Y, Wang Q, Liao Z, Wu J, Yu S, Yan H, Xie Z
Stem cell research & therapy 2026 Mar 16;17(1)
Stem cell research & therapy 2026 Mar 16;17(1)
Study on the effects and mechanisms of M2 macrophages on PYCR1-promoted biological behavior of hepatocellular carcinoma cells.
Jin X, Hou Y, Guo J, Zhang J, Wu W
Scientific reports 2026 Mar 16;16(1)
Scientific reports 2026 Mar 16;16(1)
CXCL12 Promotes Peripheral Nerve Injury Repair by Inhibiting the Ferroptosis-Inflammation Axis via the ERK/Nrf2 Pathway.
Yuan Y, Jiang Y, Du S, Yuan G, Yang Z, Wang P
Inflammation 2026 Mar 12;49(1)
Inflammation 2026 Mar 12;49(1)
ROS-Responsive Prodrug Containing Dihydroartemisinin and Cinnamaldehyde for the Potential Treatment of Nonalcoholic Steatohepatitis.
Hao R, Sun Y, Wang C, Wang Y, Li L, Sun H, Chen L
ACS applied materials & interfaces 2026 Mar 11;18(9):13384-13397
ACS applied materials & interfaces 2026 Mar 11;18(9):13384-13397
MAPK14/SLC7A11/GPX4 axis dysregulation drives podocyte ferroptosis via mediating glycerophospholipid metabolism.
Qiu S, Xie D, Guo S, Wang Z, Cai Y, Wang X, Hu Z, Wang S, Lin C, Yao H, Yang Q, Guan Y, Zhao Q, Tang S, Sun W, Xie Y, Zhang A
Cell death discovery 2026 Mar 11;12(1)
Cell death discovery 2026 Mar 11;12(1)
Paeoniflorin mitigates myocardial hypertrophy by regulating mitophagy and ferroptosis mediated by mitochondria-associated AMPK-Parkin-ACSL4 pathway.
Wang Y, Lin S, Liu J, Hu S, Zeng J, Wang M, Li X, He Y, Ren S, Lyu Y, Jia W, Zhao Y, Lin Y
Free radical biology & medicine 2026 Mar 1;245:98-114
Free radical biology & medicine 2026 Mar 1;245:98-114
Targeting HIF-1α promotes ferroptosis and boosts antitumor immunity in MSS colorectal cancer.
Yang Z, Ma R, Wu W, Shi Y, Chen Y, Luo X, Li K, Wu L, Wang B, Zhang B, Yuan P
Redox biology 2026 Jun;93:104151
Redox biology 2026 Jun;93:104151
A mitochondria-targeted nanoantioxidant restores alveolar bone homeostasis in periodontitis by quenching ROS and suppressing the cGAS-STING pathway.
Huang N, Cao L, Xu Y, Pan L, Zheng A, Wang X, Jiang X
Bioactive materials 2026 Jun;60:574-589
Bioactive materials 2026 Jun;60:574-589
Enhancing exosomes efficacy with engineered nanozymes for a multi-targeted combination strategy in osteoarthritis treatment.
Xu C, Ni Z, Wang Q, Li H, Wu L, Shi Y, Chen X, Li Z, Kang H, Liu Y, Liu Z, Wang F
Materials today. Bio 2026 Jun;38:103118
Materials today. Bio 2026 Jun;38:103118
Phycocyanin-functionalized selenium nanoparticles attenuate osteoarthritis through ferroptosis suppression and modulation of the MAPK pathway.
Hu J, Luo P, Zhang W, Chen T, Yang X, Chen Z, Huang S, Zhang X, Kuang Z, Zhang B
Materials today. Bio 2026 Jun;38:103113
Materials today. Bio 2026 Jun;38:103113
Bufotenidine attenuates astrocyte ferroptosis in depressive-like behaviors through targeting GluA1 to reduce neuronal lipid synthesis.
Wu W, Chen Z, Xu Y, Xie X, Tan A, Hu M, Xu D, Lv X, Chen W, Zhou J, Zhu Y, Ma H
Free radical biology & medicine 2026 Jun;249:589-602
Free radical biology & medicine 2026 Jun;249:589-602
METTL3-mediated m(6)A modification contributes to anlotinib resistance in osteosarcoma by regulating ferroptosis via the circFAM120B/miR-330-3p/PRKDC axis.
Zhang Y, Meng T, Chen L, Li J, Li K
Free radical biology & medicine 2026 Jun;249:409-423
Free radical biology & medicine 2026 Jun;249:409-423
STAT3 inhibition ameliorates cognitive dysfunction in type 2 diabetes mellitus by modulating astrocytes via Nrf2 pathway activation.
Wang J, Chen P, Li Y, Wang R, Ding W, Yu R, Qin Q, Wu R, Wei W, Shi J, Yuan H, Zhuang C, Sun Y
Free radical biology & medicine 2026 Jun;249:165-179
Free radical biology & medicine 2026 Jun;249:165-179
Astragaloside IV mitigates myocardial ischemia/reperfusion injury by modulating the 14-3-3η/GPX4 axis, reducing mitochondrial dysfunction, ferroptosis, and apoptosis.
Zeng RY, Qiu ZC, Zhao ST, Lai SQ, Qiu RB, Wu ZM, Xu ZQ, Li JN, Luo XD, Wang BL, Wan L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158082
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158082
The Berberine Derivative BBR684 Inhibits VDAC Oligomerization to Suppress Ferroptosis in Acute Kidney Injury.
Jiang Z, Zhang W, Zhu J, Wang C, Chen G, Guo Y
Current therapeutic research, clinical and experimental 2026 Jun;104:100825
Current therapeutic research, clinical and experimental 2026 Jun;104:100825
Hydroxyl radical from iridium(III)-based photosensitizer triggers PANoptosis and ferroptosis for hypoxia-tolerant photodynamic immunotherapy.
Liu Y, Kang T, Shi C, Wei F, Zhong Y, Hong X, Zhang J, Li K
Bioorganic chemistry 2026 Jun 5;173:109623
Bioorganic chemistry 2026 Jun 5;173:109623
Synergistic induction of ferroptosis by paclitaxel and sunitinib is mediated through SLC7A11 in lung cancer.
Jin M, Hu J, Zheng A, Wu H, Liu S, Wu C, Liu J, Shen H, Han F
International immunopharmacology 2026 Jun 15;179:116595
International immunopharmacology 2026 Jun 15;179:116595
Layered double hydroxide nanoplatform synergizes with sonodynamic therapy to induce dual activation of cuproptosis and ferroptosis for breast cancer treatment.
Zhu Q, Wang Z, Xia L, Zhou F, Zhou Z, Sun J, Li Y, Wang L, Li Y, Yan L, Mei W, Yang Q, Zhang M, Wang W
Bioorganic chemistry 2026 Jun 15;174:109746
Bioorganic chemistry 2026 Jun 15;174:109746
KLF16 transcriptionally activates HSPB1 to participate in the sorafenib resistance of hepatocellular carcinoma by driving ferroptosis resistance.
Kong S, Zhao C, Lu F, Li Y
Pathology, research and practice 2026 Jul;283:156496
Pathology, research and practice 2026 Jul;283:156496
CDDO-Me alleviates doxorubicin/lapatinib-induced cardiotoxicity by activating the NRF2/GPX4 axis to inhibit oxidative stress and ferroptosis.
Chen X, Chen B, Hu Q, Suo L, Yin M, Huang G, Huang Z, Yin Y, Zhou W
Free radical biology & medicine 2026 Jul;250:468-482
Free radical biology & medicine 2026 Jul;250:468-482
4-Octyl itaconate attenuates radiation-induced intestinal injury associated with ferroptosis inhibition and microbiota rebalance.
Zhang S, Yue T, Jin P, Zhang X, Huo Q, Li W, Tian C, Dong H, Dong Y, Zhao Y, Li D
Free radical biology & medicine 2026 Jul;250:386-398
Free radical biology & medicine 2026 Jul;250:386-398
DPP4 suppresses pancreatic cancer growth by enhancing ferroptosis sensitivity through stabilization of ACSL4.
Zhou X, Kong L, Zhang B, Xie S, Wang W, Chen G
Cellular signalling 2026 Jul;143:112446
Cellular signalling 2026 Jul;143:112446
Pyrvinium pamoate inhibits the survival of intracellular Mycobacterium tuberculosis through suppression of macrophage ferroptosis.
Guan Q, Zhou Y, Han JL, Guo F, Li Z, Zhou Y, Zhang XL
Bioorganic chemistry 2026 Jul 5;175:109753
Bioorganic chemistry 2026 Jul 5;175:109753
PTK6 promotes ferroptosis resistance and CD8(+) T cell exhaustion in pancreatic tumors via reprogramming glucose and lipid metabolism.
Zheng R, Wang S, Li D, Tian X, Sun L, Wang J, Wang Y, Pan X, Liang Y, Yang Z
International immunopharmacology 2026 Jul 15;181:116744
International immunopharmacology 2026 Jul 15;181:116744
MDM2-GPX4-ferroptosis regulatory axis exerts neurotoxic effects in intracerebral hemorrhage.
Yu Y, Liu T, Cai Y, Song Y, Zhou H, Cao F, Jiang R
Neural regeneration research 2026 Jul 1;21(7):3063-3072
Neural regeneration research 2026 Jul 1;21(7):3063-3072
Sodium Houttuyfonate improves cognitive impairment in mice after chronic sleep deprivation by inhibiting microglial inflammation and ferroptosis.
Li R, Zhu Y, Wei H, Yu M, Xu Y
International immunopharmacology 2026 Jul 1;180:116688
International immunopharmacology 2026 Jul 1;180:116688
Artemisinin Protects Diabetic Cardiomyopathy by Inhibiting Ferroptosis via Upregulating Nrf2/NQO1 and GPX4 Pathways.
Li D, Song C, Huang L, Zhao X
Molecular nutrition & food research 2026 Jan;70(1):e70296
Molecular nutrition & food research 2026 Jan;70(1):e70296
Metformin alleviates presbycusis by activating the SIRT1/PINK1/GPX4 pathway in vitro and in vivo.
Zeng C, Lin W, Gu X, Chen X, Lin Y, Chen Y, Chen Z, Lin C
Inflammopharmacology 2026 Jan;34(1):729-741
Inflammopharmacology 2026 Jan;34(1):729-741
Mechanism of tectorigenin in promoting thermal burn wound healing via the Nrf2-mediated ferroptosis pathway: Integrated pharmacological and experimental study.
Bashir A, Mei W, Zhang L, Khan MA, Nisar MF, Zhong JL
International journal of biological macromolecules 2026 Jan;339(Pt 1):149890
International journal of biological macromolecules 2026 Jan;339(Pt 1):149890
USP7 inhibitor P5091 enhances the antitumor efficacy of vemurafenib in BRAF(V600E)-mutant thyroid cancer via ferroptosis.
Hu C, Tian W, Tang Y, Wang P, Kuan T, Wei W, Chen D, Li P, Su X
Biochemical pharmacology 2026 Jan;243(Pt 2):117522
Biochemical pharmacology 2026 Jan;243(Pt 2):117522
Chloride Channel-3 promotes ferroptosis of traumatic brain injury via SGK1/GSK3β pathway.
Nie Z, Fu H, Lu C, Tan L, Zhou J, Niu J, Liang R, Fang L, Fu Y, Zheng L, Wang B
Free radical biology & medicine 2026 Jan;242:474-484
Free radical biology & medicine 2026 Jan;242:474-484
Dual-PPARα/δ agonist H11 alleviates tendinopathy via modulating the Nrf2/HO-1/GPX4 pathway.
Lu Y, Yang S, Liu H, Zhang Y, Li Z, Lu J, Jiang Q, Xu X
Free radical biology & medicine 2026 Jan;242:333-344
Free radical biology & medicine 2026 Jan;242:333-344
TRIM37 regulates HMGB1 ubiquitination to inhibit ferroptosis in Schwann cells and alleviate peripheral nerve injury.
Zhou X, You Y, Zhong L, Peng W, Yang Y, Qi J
Brain research bulletin 2026 Jan;234:111701
Brain research bulletin 2026 Jan;234:111701
SS-31 improves post-cardiac arrest brain injury by inhibiting microglial ferroptosis and polarization.
Jiang T, Zhang H, Sun Y, Ji X, Xue L, Pan C, Guo Y, Xu F
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2026 Jan;23(1):e00772
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2026 Jan;23(1):e00772
Fisetin Ameliorates Vascular Calcification by Regulating HNRNPA1-Mediated Ferroptosis.
Feng Q, He L, He Y, Li X, Xu R, Xu X, Jiang T, He Y
Annals of vascular surgery 2026 Jan;122:76-85
Annals of vascular surgery 2026 Jan;122:76-85
Shikonin improves intestinal barrier function through modulation of GPX4 expression in intestinal epithelial cells.
Yang F, Liang P, Guo H, Yan W, Wang G, Tang X, Liang Z
International journal of immunopathology and pharmacology 2026 Jan-Dec;40:3946320261427239
International journal of immunopathology and pharmacology 2026 Jan-Dec;40:3946320261427239
Eleutheroside E Attenuates Doxorubicin-Induced Cardiotoxicity by Suppressing Ferroptosis Through Activation of the Nrf2/SLC7A11/GPX4 Signaling Pathway.
Sun P, Chen L, Chen X, Zhang X, Guan J, Mo H, Liang Y, Li J, Yan J, Chen D, Zhong C, Yang P
Journal of cardiovascular pharmacology and therapeutics 2026 Jan-Dec;31:10742484261428559
Journal of cardiovascular pharmacology and therapeutics 2026 Jan-Dec;31:10742484261428559
Ferroptosis/Apoptosis Induction by an Iridium Complex Encapsulated in PLGA Nanoparticles Enhances Efficacy and Reduces Toxicity in Breast Cancer.
Liu S, Wu W, Fang L, Rao Z, Peng J, Wang X, Yu C, Wang J
Journal of medicinal chemistry 2026 Jan 8;69(1):146-162
Journal of medicinal chemistry 2026 Jan 8;69(1):146-162
HucMSC-derived exosomes alleviate chemotherapy-induced premature ovarian insufficiency via SMURF1-mediated inhibition of ferroptosis in ovarian granulosa cells.
Xu B, Han H, Hao Y, Shang Y, Deng Y, Zhang Z, Ding L, Pei X, Fu X
Stem cell research & therapy 2026 Jan 8;17(1):70
Stem cell research & therapy 2026 Jan 8;17(1):70
Chlorella-derived extracellular vesicle-based nanogels suppress cGAS-STING for treatment of radiation-induced lung injury.
Hu H, Lu F, Zhang W, Zhang Z, Cui J, Lei X, Xia J, Xu F
Nature communications 2026 Jan 8;17(1):1403
Nature communications 2026 Jan 8;17(1):1403
Fuxin decoction regulates the Nrf2/SLC7A11/GPX4 pathway to ameliorate doxorubicin-induced ferroptosis in cardiomyocytes.
Han Q, Guo Y, Yu Y, Shi J, Yuan H, Yu H, Liu X, Xue Y, Li Y
Journal of ethnopharmacology 2026 Jan 30;355(Pt B):120037
Journal of ethnopharmacology 2026 Jan 30;355(Pt B):120037
Dictamnine inhibited keratinocyte hyperproliferation and alleviated psoriasis-like dermatitis via blocking HIF1A-mediated ferroptotic pathway.
Wang W, Zhang J, Jiang SL, Rao ZM, Liu H, Wang L, Cai CL, Xu XC, Yu CH, Wang W
Journal of ethnopharmacology 2026 Jan 30;355(Pt A):120607
Journal of ethnopharmacology 2026 Jan 30;355(Pt A):120607
Rottlerin triggers dual degradation of SLC7A11 and GPX4 to drive ferroptosis and chemosensitization in hepatocellular carcinoma.
Luo H, Jin X, Gao C, Deng Q, Han L, Hu F, Tong R, Li D, Yang H, Bian X
Cell death discovery 2026 Jan 30;12(1):89
Cell death discovery 2026 Jan 30;12(1):89
Solasonine inhibits NSCLC malignant progression by regulating SLC7A11 ubiquitination degradation and inducing ferroptosis.
Wang Y, Li X, Zhou C, Qian M, Zou Z, Yang W, Wilfred NSJ, Huang G, Xu X, Xue F, Jin M
Respiratory research 2026 Jan 28;27(1):90
Respiratory research 2026 Jan 28;27(1):90
Quercetin induces ferroptosis in ovarian cancer through regulating HSPB1/Notch1 pathway.
Zhao B, Zhu H, Qian H, Zhang J, Hu X, Fu F, Ji H, Zhu X
Journal of ovarian research 2026 Jan 28;19(1)
Journal of ovarian research 2026 Jan 28;19(1)
Qing-Chang-Hua-Shi granule ameliorates experimental colitis by modulating Lactobacillus gasseri-mediated ferroptosis metabolic pathway.
Cheng C, Zhu L, Hu J, Feng W, Li W, Au R, Li Y, Xu F, Wu Y, Cui Y, Di Z, Li B, Miao Y, Lin Y, Ge L, Shen H
Chinese medicine 2026 Jan 26;21(1):52
Chinese medicine 2026 Jan 26;21(1):52
Inhibition of the RORC/GPX4 mediated ferroptosis regulatory axis suppresses tumor growth and alleviates enzalutamide resistance in prostate cancer.
Li Y, Zhang B, Zhang Z, Yan W, Wang H, Xu X, Lv A, Liao Z, Guo L
Cellular & molecular biology letters 2026 Jan 24;31(1):11
Cellular & molecular biology letters 2026 Jan 24;31(1):11
Ferroptosis-related gene signature predicts prognosis and immunotherapy response in hepatocellular carcinoma: A multi-cohort retrospective study.
Li L, Pang J, Chen J, Pan Y, Liang L, Bai X, He Y, Yang H
Medicine 2026 Jan 23;105(4):e47262
Medicine 2026 Jan 23;105(4):e47262
Long noncoding RNA PCAT7 confers radioresistance of esophageal squamous cell carcinoma by promoting GCLM-mediated anti-ferroptosis.
Hao Y, Zhao X, Shi X, Zhang J, Zhang X, Ke Y, Guo W, Ma X, Liu X, Wang Y, Zhang R, Wang X, Ma H, Pan S
Journal of translational medicine 2026 Jan 21;24(1):242
Journal of translational medicine 2026 Jan 21;24(1):242
MEN1 Promotes Ferroptosis by Disrupting CD44 Alternative Splicing to Suppress Lung Cancer.
Pan T, Zhu J, Wang X, Tang D, Wang Z, Yang Y, Teng Y, Tian Q, Dan G, Chen C, Yu D, Liu M, Wang H, Zhang T, Guo B, Chen T, Jin B
Cancer research 2026 Jan 2;86(1):146-166
Cancer research 2026 Jan 2;86(1):146-166
Intravesical instillation of pirfenidone/polydopamine nanoparticles for managing neurogenic bladder post-spinal cord injury by alleviating bladder inflammation and fibrosis.
Zhang J, Li H, Zhang L, Lv L, Zang M, Wang X, Wang S, Chen L, Yang Z, Yang L, Zhao J, Gao X, Guo D, Shi B, Zhang Z, Li Y
Journal of nanobiotechnology 2026 Jan 17;24(1):154
Journal of nanobiotechnology 2026 Jan 17;24(1):154
Moscatilin alleviates severe acute pancreatitis by activating the NRF2/HO-1 pathway to inhibit ferroptosis.
Niu L, Yang Z, Zeng Y, Huang Z, Yang T, Liu S, Zhong H, Ye M, Lei S, Gao L, Tan P, Fu W
International immunopharmacology 2026 Jan 15;169:115972
International immunopharmacology 2026 Jan 15;169:115972
Celastrol mitigates diabetic kidney disease by inhibiting ferroptosis via the SIRT1/NRF2/GPX4 pathway.
Tang YW, Xu TJ, Cao JW, Jiang MY, Yang RC, Wan F
Diabetology & metabolic syndrome 2026 Jan 13;18(1):55
Diabetology & metabolic syndrome 2026 Jan 13;18(1):55
Erk5-mediated microglial ferroptosis drives ischemic white matter damage via the Nfatc4-Clptm1l axis.
Chu YH, Zhang LY, He JY, Wang YF, Dong MH, You YF, Pang XW, Zhu LF, Zhang H, Xu LL, Chen L, Zhou LQ, Xiao J, Shang K, Gong JK, Wang W, Tian DS, Qin C
Proceedings of the National Academy of Sciences of the United States of America 2026 Jan 13;123(2):e2521757123
Proceedings of the National Academy of Sciences of the United States of America 2026 Jan 13;123(2):e2521757123
Dunaliella salina-Loaded Diosmetin Carriers Alleviate Oxidative Stress and Inflammation in Cisplatin-Induced Acute Kidney Injury via PI3K/AKT Pathway.
Huangfu Y, Chen W, Guo D, Wang P, Li A, Yang Y, Li S, Wang Q, Wang B, Feng S
Pharmaceutics 2026 Jan 12;18(1)
Pharmaceutics 2026 Jan 12;18(1)
The role of GPD2 on ferroptosis in sepsis-induced acute lung injury.
Han Y, Dai C, Hu D, Yao Y, Peng W, Zheng Y, Zeng Q, Xie H, Huang J
Biochemical and biophysical research communications 2026 Jan 1;794:153066
Biochemical and biophysical research communications 2026 Jan 1;794:153066
Licochalcone D modulates macrophage ferroptosis via suppression of VPS4A-mediated lipophagy to alleviate MRSA pneumonia.
Zhang H, Liu X, Han Q, Zhang Q, Lv N, Gan X, Tong Z, Zhang J, Zhang W, Shi L
International immunopharmacology 2026 Jan 1;168(Pt 2):115918
International immunopharmacology 2026 Jan 1;168(Pt 2):115918
Modulation of Macrophage ferroptosis under the guide of infrared thermography promotes the healing of pressure injuries.
Jiang X, Zhang X, Deng H, Lin L, Wang Y, Wang Y, Huang J, Yang N, Xu S, Wang J, Shi K, Tao K, Chen Z, Cai F, Zhou K, Xiao J
Journal of advanced research 2026 Feb;80:265-285
Journal of advanced research 2026 Feb;80:265-285
Heme oxygenase 1 (HO-1) is a drug target for reversing cisplatin resistance in non-small cell lung cancer.
Mei J, Tian HX, Zhang XY, Chen YS, Wang LY, Zhang Z, Zhang YL, Rong DC, Zeng J, Dong M, Gao Y, Yin JY, Wu HJ, Wang PY, Zhang W
Journal of advanced research 2026 Feb;80:1121-1137
Journal of advanced research 2026 Feb;80:1121-1137
Hsa-miR-526b-5p Regulates the Sensitivity of Colorectal Cancer to 5-Fluorouracil by Targeting TP53 in Organoid Models.
Huang L, Liao C, Xiong Z, Chen Z, Zhang S
Biochemical genetics 2026 Feb;64(1):660-683
Biochemical genetics 2026 Feb;64(1):660-683
Soufeng Yuchuan formula alleviates asthma airway inflammation and suppresses the progression of asthma by inhibiting ferroptosis in airway epithelial cells.
Mumu W, Xiaoyu Y, Yujing Z, Xinxin Z, Yongbin Y
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2026 Feb;46(1):73-84
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2026 Feb;46(1):73-84
Integrating TWAS, chemical-genomic networks, and experimental models: melatonin as a ferroptosis inhibitor in osteoarthritis therapy.
Feng R, Aihaiti Y, Yu H, Xu K, Lu C, Xu P
Clinical rheumatology 2026 Feb;45(2):1559-1572
Clinical rheumatology 2026 Feb;45(2):1559-1572
THRA Orchestrates Myocardial Protection Against Hypothyroidism-Induced Ferroptosis via the GATA4-GPX4 Transcriptional Cascade.
Runfang Z, Fa X
Antioxidants & redox signaling 2026 Feb;44(4-6):236-250
Antioxidants & redox signaling 2026 Feb;44(4-6):236-250
Overexpression of OTUD5 in IPSCs-derived extracellular vesicles promotes angiogenesis after myocardial infarction by inhibiting endothelial cell ferroptosis.
Lu D, Chen D, Cao R, Zhang X, Liang J, Zhu F, Si K, Jiang W
Nutrition, metabolism, and cardiovascular diseases : NMCD 2026 Feb;36(2):104374
Nutrition, metabolism, and cardiovascular diseases : NMCD 2026 Feb;36(2):104374
Antimony Exposure Promotes Periodontitis by Activating Ferroptosis Pathway.
Zhou Y, Yuan F, Zhang R, Wang J, Muhaisen BOM, Tang C
Oral diseases 2026 Feb;32(2):550-565
Oral diseases 2026 Feb;32(2):550-565
AGEs promote the metastasis of colorectal cancer cells via centrosome amplification by KLF5-CEP57L1 axis.
Zhao JZ, Fan SX, Guo JL, Lu YC, Bian XK, Han YW, Xu SX, Zhao ML, Li YF, Li RP, Lee SC
The Journal of biological chemistry 2026 Feb;302(2):111098
The Journal of biological chemistry 2026 Feb;302(2):111098
Smart responsive injectable hydrogel loaded with icariin inhibits ferroptosis and promotes nucleus pulposus repair in intervertebral disc degeneration.
Lin Z, Mai L, Luo H, Wang Z, Lin Y, Wang H, Chen S, Su G, Hu X, Chen B, Cao X
Biomaterials advances 2026 Feb;179:214513
Biomaterials advances 2026 Feb;179:214513
Herbacetin alleviates Parkinson's disease by inhibiting ferroptosis in PC12 cells through the Nrf2/GPX4 pathway.
Liu Y, Wang Y, Xi J, Fang J
Bioorganic chemistry 2026 Feb;169:109375
Bioorganic chemistry 2026 Feb;169:109375
Lipid Droplets-Targeted Thermally Activated Delayed Fluorescence Photosensitizer for Photodynamic Therapy-Mediated Ferroptosis: a New Strategy for Tumor Radiosensitization.
Xu S, Wang X, Pu K, Liu T, Pei J, Zhao X, Yu J, Liu J, Hu HY
Advanced healthcare materials 2026 Feb;15(7):e04496
Advanced healthcare materials 2026 Feb;15(7):e04496
A Functional Nanocomposite Tri-Activates Cuproptosis, Ferroptosis, and Mitophagy Death Pathway to Oppose Malignancies.
Deng K, Gao W, Wen Y, Huang J, Li X, Yang X, Wu M
Advanced healthcare materials 2026 Feb;15(6):e03530
Advanced healthcare materials 2026 Feb;15(6):e03530
Melatonin counteracts Iodoacetic acid induced ferroptosis by regulating Nrf2 in porcine oocytes.
Lu QY, Zhan CL, Lee SH, Li XH, Kim JD, Lee GH, Sim JM, Song HJ, Jin YY, Cui XS
Cellular signalling 2026 Feb;138:112257
Cellular signalling 2026 Feb;138:112257
Ir(III) Complexes Convert Cold to Hot Tumors via Ferroptosis/Necroptosis-Driven Immunogenic Cell Death and Photosensitized CD47 Downregulation.
Yu LB, Wang P, Shen QH, Guan QX, Li ZY, Han YY, Zhang XY, Hu QY, Tan CP
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(8):e14256
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(8):e14256
HSP70 Interactome-Mediated Proteolysis Targeting Chimera (HSP70-PROTAC) for Ferroptosis-Driven Cancer Treatment.
Dong J, Li Y, Liang H, Wu Z, Wang S, Wang Y, Xu J, Lan Y, Cai M, Pan G, Yang H, Miao K, Chen ZS, Tao F, Ma X, Qin JJ
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(12):e13655
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(12):e13655
USP36 inhibits ferroptosis of melanoma cells by stabilizing APEX1.
Zhang L, Zhang Y, Yin H
Clinical and experimental medicine 2026 Feb 6;26(1):142
Clinical and experimental medicine 2026 Feb 6;26(1):142
Chemical induction of ferroptosis through GPX4 inhibition: Rational design of triazole-benzoxazine hybrids for melanoma therapy.
Feng B, Chen Y, Fu H, Li Y, Guo J, Hou X, Xu H, Xu S
European journal of medicinal chemistry 2026 Feb 5;303:118434
European journal of medicinal chemistry 2026 Feb 5;303:118434
Combining network pharmacology and experimental validation to demonstrate that salidroside alleviates acute lung injury by inhibiting ferroptosis via the MAPK/GPX4 pathway.
Zhao M, Fang W, Chen M, Wang MQ, Lin W
Respiratory research 2026 Feb 4;27(1)
Respiratory research 2026 Feb 4;27(1)
Integrative metabolomic and single-cell transcriptomic analysis of recurrent condyloma acuminatum in humans.
Wei Y, Xu Y, Feng C, Chen S, Chen J, Wang J, Pan J, Song Y, Hua C, Cai M, Cheng H, Zhu J
Scientific reports 2026 Feb 4;16(1)
Scientific reports 2026 Feb 4;16(1)
miR-320a enhances radiosensitivity in non-small cell lung cancer by targeting RAD51 and modulating ferroptosis via GPX4.
Lv J, Zhang C, Ren X, Geng F, Li S, Wang Z, Quan X, Cheng Z, Wang R
Scientific reports 2026 Feb 28;16(1)
Scientific reports 2026 Feb 28;16(1)
Hydroxytyrosol Prevents Metabolic-Associated Steatohepatitis by Inhibiting SOCS2-Mediated Ferroptosis in High-Fat Diet Mice.
Yi D, Wu Z, Li X, Shao B, Xiao Y, Li T, Zhang X, Zhu J, Yang T, Deng Y, Huang T, Qiu T, Bai J, Shi X, Wu C, Wu Z, Sun X, Wang N
Journal of agricultural and food chemistry 2026 Feb 25;74(7):6265-6277
Journal of agricultural and food chemistry 2026 Feb 25;74(7):6265-6277
Sinensetin attenuates post-stroke depression via dual modulation of TLR4/NF-κB-NRF2/GPX4 pathways.
Fan Q, Huang R, Luo K, Chen J, Yin X, Zhao E, Liu Y, Sheng L, Wang Q, Cai W
Scientific reports 2026 Feb 21;16(1)
Scientific reports 2026 Feb 21;16(1)
Expression patterns of glutathione peroxidases family members during tooth development.
Zhou K, Tian Q, Zheng L, Du W
Journal of molecular histology 2026 Feb 20;57(2)
Journal of molecular histology 2026 Feb 20;57(2)
Synergistic microenvironment therapy: a dual-function nanogel of supramolecular collagen ll-mimetic matrix and antioxidant MXene for attenuating intervertebral disc degeneration.
Lyu G, Gao Z, Cao Z, Zhou Q, Chen Y, Yang S, Liang H, Lu X, Li S, Wang X, Sun S, Gao X, Zhou Y, Wu A, Zhou X, Wang X
Journal of nanobiotechnology 2026 Feb 19;24(1)
Journal of nanobiotechnology 2026 Feb 19;24(1)
Saposhnikovia divaricata Inhibits Inflammation, Oxidative Stress, and Ferroptosis to Alleviate DSS-Induced Ulcerative Colitis.
Liu L, Dou Q, Zhao X, Liang Y, Tian Z, Su D, Zhou L, Hu X
Antioxidants (Basel, Switzerland) 2026 Feb 18;15(2)
Antioxidants (Basel, Switzerland) 2026 Feb 18;15(2)
SREBP1 knockdown triggers ferroptosis by suppressing the Nrf2-XCT/GPX4 axis in ovarian cancer.
Nie R, Zhou H, Chen L, Quan H, Zhang Y, Lin Z
Cell death discovery 2026 Feb 18;12(1)
Cell death discovery 2026 Feb 18;12(1)
CircRNA-TMEM71 Inhibits Human Aortic Smooth Muscle Cell Ferroptosis and Prevents Aortic Dissection Formation Through IGF2BP3-Mediated Stability of FSP1.
Zhu L, He C, Shi H, Shao G, Sun L
Journal of the American Heart Association 2026 Feb 17;15(4):e043108
Journal of the American Heart Association 2026 Feb 17;15(4):e043108
LBPs NPs suppress breast cancer progression by inhibiting YAP1 expression to induce ferroptosis and alter energy metabolism.
Zhao F, Yang S, He T, Yang L, Mo T, Kang J, Cao H, Sun X, Yu Y
Scientific reports 2026 Feb 16;16(1)
Scientific reports 2026 Feb 16;16(1)
Akkermansia muciniphila affects colitis by inhibiting ferroptosis signaling pathway.
Zhang L, Liu Y, Wei K, Wang J, Lin W, Zhuo S, Guan G
Scientific reports 2026 Feb 16;16(1)
Scientific reports 2026 Feb 16;16(1)
Integrated multi-omics analysis reveals GPD1L-mediated dysregulation of glycerophospholipid metabolism facilitates the progression of lung adenocarcinoma.
Sun Y, Yan Y, Zhou Y, Chen Y, Liu C, Bao Y, Zhang Y, Han H, Chen H
Respiratory research 2026 Feb 14;27(1):86
Respiratory research 2026 Feb 14;27(1):86
An intrabody targeting PHD2 protects mice against acetaminophen-induced liver injury by attenuating ferroptosis.
Ren Z, Wang Y, Cheng C, Zhang Y, Liu Y, Wei Y, Liu Z, Zhang J, Shi Z, Yu J, Hu W, Ye J, Wang J, Qiu S, Li G
Free radical biology & medicine 2026 Feb 1;243:260-275
Free radical biology & medicine 2026 Feb 1;243:260-275
Bromodomain-containing protein 4 knockdown promotes neuronal ferroptosis in a mouse model of subarachnoid hemorrhage.
Lu P, Zhang F, Yang L, He Y, Kong X, Guo K, Xie Y, Xie H, Xie B, Jiang Y, Peng J
Neural regeneration research 2026 Feb 1;21(2):715-729
Neural regeneration research 2026 Feb 1;21(2):715-729
Multi-omics unravels multiple pharmacological actions in a murine model of infantile hemangioma receiving oxymatrine therapy.
Wang Y, Peng J, Qiu M, Dai Y, Wang S, Ou J, Yan J
Discover oncology 2026 Feb 1;17(1)
Discover oncology 2026 Feb 1;17(1)
Qigui didang decoction alleviates renal injury in a diabetic kidney disease model with metabolic memory features: association with ferroptosis and the SIRT1/Nrf2 pathway.
Wu Y, Fan L, You H, Lu Y, Lin M
Pharmaceutical biology 2026 Dec;64(1):536-555
Pharmaceutical biology 2026 Dec;64(1):536-555
Ginkgolic acid targets HSPA8 to trigger ferroptosis in hepatocellular carcinoma via chaperone-mediated autophagy-dependent GPX4 degradation.
Liu R, Zhang Y, Zou H, Zhang M, Yang Z, Liao K, Wang G, Liu B, Tang L, Kang X, Zheng S
Pharmaceutical biology 2026 Dec;64(1):514-535
Pharmaceutical biology 2026 Dec;64(1):514-535
Low, plasma level‑informed native curcumin concentrations fail to induce cell death in human lung and colorectal cancer cells.
Imtiaz I, Schloss J, Bugarcic A
Pharmaceutical biology 2026 Dec;64(1):471-486
Pharmaceutical biology 2026 Dec;64(1):471-486
lncRNA MALAT1-mediated regulation of cholesterol-oxidative stress-iron metabolic dysregulation by paeoniflorin in osteoarthritic chondrocytes.
Fu C, Lan S, Lin Y, Chen D, Yang Z, Chen C, Chen Y, Yuan Y, Zhong W, Lin Q, Huang Z
Pharmaceutical biology 2026 Dec;64(1):278-294
Pharmaceutical biology 2026 Dec;64(1):278-294
Endogenous H₂S promotes HSPA8 sulfhydration to downregulate HIF1α and prevent ferroptosis in septic myocardial injury.
Jiankui D, Zhang S, Li Z, Li W, Weina L, Miao W, Jian X, Changnan W
Redox report : communications in free radical research 2026 Dec;31(1):2626159
Redox report : communications in free radical research 2026 Dec;31(1):2626159
EP300 attenuates ferroptosis and stimulates proliferation, migration, and fibrosis of keloid fibroblasts via YY1/GPX4 axis.
Jin J, Wang K, Lu C, Yao C, Xie F
Cell cycle (Georgetown, Tex.) 2026 Dec;25(1):1-16
Cell cycle (Georgetown, Tex.) 2026 Dec;25(1):1-16
Comparative effects of dietary resveratrol and pterostilbene on meat quality, muscle antioxidant capacity, and muscle fiber composition in finishing pigs.
Huang T, Chen X, Chen D, Yu B, Zheng P, Yan H, Luo Y, Huang Z
Meat science 2026 Aug;238:110113
Meat science 2026 Aug;238:110113
Xin Jia congrong tusizi decoction reverses ferroptosis in granulosa cells to rescue ovarian function decline via p53/Nrf2/SLC7A11/GPX4 signaling pathway.
Liu M, Sun Y, Liu X, Wei S, Yang J, Wang Y, Wu K, Wu Y
Journal of ethnopharmacology 2026 Aug 10;367:121659
Journal of ethnopharmacology 2026 Aug 10;367:121659
SIRT7 facilitates ferroptosis resistance of melanocytes via activating the SMAD3-ATF3-GPX4 signaling pathway in vitiligo.
Wu L, Guo W, Wang H, Yang Y, Zhang H, He L, Chen J, He K, Wang X, Kang P, Chen J, Jiang L, Guo S, Chang Y, Jian Z, Li S, Sato Y, Yamagata K, Gao T, Yi X, Li C
Journal of advanced research 2026 Apr;82:901-916
Journal of advanced research 2026 Apr;82:901-916
Electroacupuncture regulates neuronal ferroptosis and ferritinophagy through lysosomal-mediated TFEB activation in cerebral ischemia-reperfusion.
Tang B, Xu X, Zhao W, Zhou Q, Du G, Wang H
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2026 Apr;46(4):963-975
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2026 Apr;46(4):963-975
Application of a novel myristoylproteomics approach identifies GLIPR2 as a key pro-ferroptotic substrate in non-small cell lung cancer.
Wang Y, Guo S, Guo W, Tian X, Miao Y, Qiu S, Xue X, Wang Y, Cui J, Xu X, Wang J, Zhang X
Materials today. Bio 2026 Apr;37:102945
Materials today. Bio 2026 Apr;37:102945
Injectable Zn(2+)-Driven carrier-free hydrogel via self-assembly of natural small molecules for liver fibrosis therapy through concurrent autophagy activation and ferroptosis inhibition.
Zhu C, Jia S, Wang J, Gao F, Lin Y, Nie A, Guo Z, Zhou Z, Xu B, Lei H
Materials today. Bio 2026 Apr;37:102828
Materials today. Bio 2026 Apr;37:102828
Puerarin promotes nerve regeneration and functional recovery after peripheral nerve injury by inhibiting ACSL4-dependent ferroptosis.
Sun T, Huang L, Zhao Y, Sun Q, Luo X, Wu Z, Sun J, Li M, Huo Q, Wang H
International journal of biological macromolecules 2026 Apr;357:151404
International journal of biological macromolecules 2026 Apr;357:151404
Riboflavin metabolism shapes FSP1-driven ferroptosis resistance.
Skafar V, de Souza I, Ghosh B, Ferreira Dos Santos A, Porto Freitas F, Chen Z, Sun S, Donate Castillo M, Nepachalovich P, Seufert L, Bothe S, Tschuck J, Mathur A, Nunes-Alves A, Buhr J, Aponte-Santamaría C, Schmitz W, Mack M, Eilers M, Bargou R, Chaufan M, Kaur M, Palma M, Ubellacker JM, Elling U, Augustin HG, Hadian K, Meierjohann S, Proneth B, Conrad M, Fedorova M, Alborzinia H, Friedmann Angeli JP
Nature cell biology 2026 Apr;28(4):696-706
Nature cell biology 2026 Apr;28(4):696-706
Nanomagnetic Hyperthermia Sensitizes Gemcitabine Chemosensitivity in Pancreatic Cancer by Inhibiting HSPB1 to Amplify ACSL4-Mediated Ferroptosis.
Ren J, Wu S, Su T, Li H, Ding J, Chen F, Mo J, Li J, Wang Z, Han L, Wu Z
Small (Weinheim an der Bergstrasse, Germany) 2026 Apr;22(22):e14973
Small (Weinheim an der Bergstrasse, Germany) 2026 Apr;22(22):e14973
The ovarian tumor domain-containing protein 4 (OTUD4)-targeted ferroptosis inhibitor Maclekarpine E attenuates ulcerative colitis.
Lv X, He Z, Xue J, Yang Y, Tang Y, Cai H, Luo H, Li X, Dong Z, Liu Y, Zeng J, Yang Z, Cheng P
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:157999
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:157999
Resveratrol dual efficacy in high-altitude hypoxia and NAFLD: inhibits ferroptosis by modulating key proteins, including HIF-1α, ACSL4, and TfR1.
Zhao M, Mu H, Ji Q, Song J, Zheng F, Liu T, Li W, Wang R
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:157992
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:157992
Apigenin-5-O-glucoside alleviates hepatic fibrosis through NOX4-mediated ferroptosis in zebrafish.
Li M, Deng K, Cheng J, Shi H, Li Y, Wang Y, Wen J, Lv Z, Huang S
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:157956
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:157956
TrxR2 Lactylation Facilitates Mitochondrial Protection and Endothelial Ferroptosis Resistance in Diabetic Cardiomyopathy.
Li S, Liu M, Chen C, Li X, Yan X, Zhu W, Qiu W, Li Q, Sun X, Huang C, Yin M, Chen Z, Lu Y, Ge J, Kong X, Qian J, Chen Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(22):e21997
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(22):e21997
Remimazolam Ameliorates Autistic-Like Behaviors via Suppression of Ferroptosis in VTA Dopaminergic Neurons in a Mouse Model of ASD.
Zhang Y, Lin J, Tong C, Fu X, Shan M, Huang Y, Zhang K, Zheng J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(20):e08520
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(20):e08520
Inhibition of Calcium-Dependent Lipid Droplets Relocation of ACSL4-PKCβ-ALOX15 Complex Alleviates Ferroptosis and Acute Pancreatitis.
Hou G, Luan J, Xu X, Qin J, Ma S, He J, Sun N, Zhang W, Gao M
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(19):e15768
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(19):e15768
TRIM21 Alleviates Alcoholic Liver Fibrosis by Inhibiting Ferroptosis Through Regulation of IDO1 Ubiquitination.
Zhong W, Luo L, Liu Y, Huang F, Meng Q, Deng G, Li Y, Liu X, Tong G, Xing Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Apr 30;40(8):e71773
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Apr 30;40(8):e71773
Ferroptosis-STING co-activation drives GzmB(+)CD38(+)CD8(+) T-cell expansion to overcome lymphoma immunosuppression.
Zhu X, Zhang D, Zhang J, Fang Z, Zhang Y, Jiang C, Xu R, Hu X
Biomaterials 2026 Apr 27;334:124250
Biomaterials 2026 Apr 27;334:124250
OLFM4 mediating ischemia/reperfusion-induced kidney injury by regulating renal tubular epithelial cells ferroptosis via GPX4.
Zhang Z, Wang Y, Mu Z, Zhao S, Zhang T, Zhang Z, Sun S, Bai M
Molecular biology reports 2026 Apr 25;53(1)
Molecular biology reports 2026 Apr 25;53(1)
PDK4 acts via hippo signaling to inhibit ferroptosis and reduce gemcitabine sensitivity in pancreatic cancer.
Jin L, Pan M, Yuan X, Zhu X, Gao T, Chen C
Journal of molecular histology 2026 Apr 22;57(3)
Journal of molecular histology 2026 Apr 22;57(3)
Enalaprilat reverses neutrophil polarization imbalance via targeting taurine-STING axis for treatment of diabetic wounds.
Lu L, Xiong Y, Liao J, Zhou J, Wang G, Qin Y, Zhang S, Zhao Y, Zhong X, Wang M, Zha K, Al-Smadi F, Liu G, Zhao Y, Mi B
Cell reports. Medicine 2026 Apr 21;7(4):102714
Cell reports. Medicine 2026 Apr 21;7(4):102714
Multi-Ion Channel Nanomedicines Targeting Zinc Transporter 1/ATPase Copper Transporters Disrupt Copper/Iron Homeostasis to Enhance Tumor Immunotherapy.
Ma G, Li Y, Li X, Yu D, Chao M, Li J, Guo J, Wang K, Liu Z, Sun R, Gao F
ACS nano 2026 Apr 21;20(15):11801-11821
ACS nano 2026 Apr 21;20(15):11801-11821
Gallic acid: A promising anti-non-small cell lung cancer compound targeting early growth response protein-1 for apoptosis and ferroptosis.
Li BB, Zhang JT, Jiang YY, Li X, Wang DN, Zang JM, Liu ZL, Hu FX, Zhu X, Shen CC, Zhang W, Xu F
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr 19;156:158220
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr 19;156:158220
Aberrant expression of TRIM26 suppresses ferroptosis through regulating GPX4 protein stability in colorectal cancer.
Wu G, Zheng K, Xu S, Wang J, Xu J
Molecular biology reports 2026 Apr 16;53(1)
Molecular biology reports 2026 Apr 16;53(1)
Molecular mechanism of testicular oxidative stress-induced ferroptosis in Leydig cells caused by cryptorchidism in yak.
Zeng J, Yuan L, Qi Y, Chen G, Chen Y, Li H, Song Y, Zhang Y
Theriogenology 2026 Apr 15;261:117946
Theriogenology 2026 Apr 15;261:117946
Non-steroidal mineralocorticoid receptor antagonist finerenone ameliorates diabetic nephropathy via suppressing SLC7A11-mediated ferroptosis.
Yu L, Zhai Z, Wang Y, Wang L, Li Q, Guo Y, Liang Y, Tang L
International immunopharmacology 2026 Apr 15;175:116448
International immunopharmacology 2026 Apr 15;175:116448
Kaempferol protects melanocytes from ferroptosis by modulating the NF-κB/PTGS2 signaling axis in vitiligo.
Xu X, Lei Z, Hu W, Wang H, Xiang F, Ding Y, Kang X
Apoptosis : an international journal on programmed cell death 2026 Apr 14;31(4)
Apoptosis : an international journal on programmed cell death 2026 Apr 14;31(4)
Saikosaponin D Alleviates Liver Ischemia-Reperfusion Injury by Inhibiting Mitophagy-Associated Ferroptosis via the STAT3/PINK1 Pathway.
Liu X, Xu Y, Yu X, Feng X, Han Y, Cai H, Du J, Chen L
Phytotherapy research : PTR 2026 Apr 12;
Phytotherapy research : PTR 2026 Apr 12;
Ferrostatin-1 attenuates sepsis-induced lung injury by inhibiting ferroptosis via activation of the SLC7A11/GSH/GPX4 signaling pathway.
Zhang H, Li H, Liu S, Zheng J, Li P
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2026 Apr 1;1273:124962
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2026 Apr 1;1273:124962
EGF-Upregulated lncRNA ESSENCE Promotes Colorectal Cancer Growth through Stabilizing CAD and Ferroptosis Defense.
Xie X, Zhang B, Peng J, Ma N, Pan Q, Wei Y, Jin H, Yu F, Huang X, Zhang P, Wang J, Zheng J, Ying X, Liu RY, Yu H, Lee MH, Meng X
Research (Washington, D.C.) 2025;8:0649
Research (Washington, D.C.) 2025;8:0649
H2S inhibits high glucose-induced osteoblast injury by inhibiting ferroptosis in diabetic osteoporosis in vitro.
Shi Q, Chen F, Wu W
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 2025;58:e14679
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 2025;58:e14679
The Combination of Celastrol and Curcumin Enhances the Antitumor Effect in Nasopharyngeal Carcinoma by Inducing Ferroptosis.
Feng T, Hu G, Luo Y, Zhang X, Chen H, Liang Z, He X, Ma S, Wei J, Fang X, Li B, Wang J, Liao S
Biological & pharmaceutical bulletin 2025;48(7):1096-1106
Biological & pharmaceutical bulletin 2025;48(7):1096-1106
Targeting p97/Valosin-Containing Protein Promotes Hepatic Stellate Cell Senescence and Mitigates Liver Fibrosis.
Yang Y, Zhang Y, Wang L, He G, Yang X, Qing J
DNA and cell biology 2025;44(3):132-143
DNA and cell biology 2025;44(3):132-143
TRIM32 promotes neuronal ferroptosis by enhancing K63-linked ubiquitination and subsequent p62-selective autophagic degradation of GPX4.
Zhou X, Zhao Y, Huang S, Shu H, Zhang Y, Yang H, Ren Y, Zhou X, Liu W, Song T, Zhao J, Ma J
International journal of biological sciences 2025;21(3):1259-1274
International journal of biological sciences 2025;21(3):1259-1274
Ferroptosis-Resistant Adipocytes Drive Keloid Pathogenesis via GPX4-Mediated Adipocyte-Mesenchymal Transition and Iron-Cystine Metabolic Communication.
Shi X, Xia X, Xiao Y, Shu H, Xu Z, Liu M, Shi C, Zhang Y, Wei Y, Gong Y, Wang W, Chen Y, Liu J, Huang J, Shi M, Wang J, Wu W
International journal of biological sciences 2025;21(11):5097-5115
International journal of biological sciences 2025;21(11):5097-5115
HMGB1 Exacerbates Intestinal Barrier Damage by Inducing Ferroptosis Through the TLR4/NF-κB/GPX4 Pathway in Ulcerative Colitis.
Zhu N, Ge X, Zhang L, Chen X, Xiang W, Mei Q
Mediators of inflammation 2025;2025:2395557
Mediators of inflammation 2025;2025:2395557
Downregulation of NCOA4 expression indicates poor prognosis and promotes the progression of cholangiocarcinoma.
Shen W, Liu Y, Dai B, Qin C, Fu Y, Li X, Liu C
PloS one 2025;20(8):e0327722
PloS one 2025;20(8):e0327722
Silencing NRF2 enhances arsenic trioxide-induced ferroptosis in hepatocellular carcinoma cells.
Huang M, Li D, Xia Z, Liao S, Si W, Yuan C, Liao Y, Wu W, Jiang M, Yu X, Quan Y
PloS one 2025;20(5):e0322746
PloS one 2025;20(5):e0322746
Dapagliflozin inhibits ferroptosis to improve chronic heart failure by regulating Nrf2/HO-1/GPX4 signaling pathway.
Zhang J, Chen X, Lv S, Hao Q
PloS one 2025;20(1):e0317295
PloS one 2025;20(1):e0317295
Self-Assembled Carrier Free Oligomeric Proanthocyanidin/Tetrandrine Nanoparticles Ameliorate Osteoarthritis via Anti-Inflammatory and Anti-Ferroptotic Pathways.
Xing C, Wu Y, Huang Y, Li W, Wang X, Chen H
International journal of nanomedicine 2025;20:13165-13181
International journal of nanomedicine 2025;20:13165-13181
MXene-Mediated Nanocarrier Delivery Enhances the Chondroprotective Effects of Quercetin in Experimental Osteoarthritis.
Gan K, Li J, Zhang X, Feng Z, Liu J, Zhao F
International journal of nanomedicine 2025;20:11553-11567
International journal of nanomedicine 2025;20:11553-11567
Exosomes Derived From Human Mesenchymal Stem Cells Mitigate Follicular Interstitial Cell Ferroptosis via the miR-26a-5p/PTEN/GPX4 Axis in Rats with Chemotherapy-Induced Premature Ovarian Insufficiency.
Chen J, Huo X, Qian M, Xue Q, He Y, Xu P, Wang Y, Tang X, Luo Q, Bao H, Xiong Y
International journal of nanomedicine 2025;20:10195-10212
International journal of nanomedicine 2025;20:10195-10212
The Protective Role of DDIT4 in Helicobacter pylori-induced Gastric Metaplasia Through Metabolic Regulation of Ferroptosis.
Wang H, Xu X, Ouyang Y, Fei X, He C, Yang X, Ren Y, Zhou Y, Chen S, Hu Y, Liu J, Ge Z, Wu WKK, Lu N, Xie C, Wu X, Zhu Y, Li N
Cellular and molecular gastroenterology and hepatology 2025;19(5):101448
Cellular and molecular gastroenterology and hepatology 2025;19(5):101448
Wedelolactone Ameliorates Ischemic Stroke by Inhibiting Oxidative Damage and Ferroptosis via HIF-1α/SLC7A11/GPX4 Signaling.
Tao X, Zhao M, Gao K, Zhang W, Xu D, Li W, Mu F, Lin R, Guo C, Li R, Wang J
Drug design, development and therapy 2025;19:6849-6868
Drug design, development and therapy 2025;19:6849-6868
Translocator protein deficiency blocks the ferroptosis of malignant peripheral nerve sheath tumors through glutathione peroxidase 4.
Zhang X, Pu Z, Ran C, Zhang X, Guo C, Deng Y, Liu J, Chen Y, Feng J, Liu S
Frontiers in cellular neuroscience 2025;19:1624817
Frontiers in cellular neuroscience 2025;19:1624817
Exploring the Kidney-Brain Crosstalk: Biomarkers for Early Detection of Kidney Injury-Related Alzheimer's Disease.
Cai Y, Huang G, Ren M, Chai Y, Fu Y, Yan T, Zhu L
Journal of inflammation research 2025;18:827-846
Journal of inflammation research 2025;18:827-846
Astragaloside IV Alleviates Osteoarthritis by Inhibiting Chondrocyte Ferroptosis via the p53/SLC7A11/GPX4 Axis.
Tang Z, Cheng L, Li M, Chen J, Huang C
Journal of inflammation research 2025;18:16169-16186
Journal of inflammation research 2025;18:16169-16186
Astragaloside IV Attenuates Chronic Prostatitis by Activating Keap1/Nrf2/HO-1 Pathway: Suppressing Ferroptosis and Enhancing Antioxidant Defense.
Shi J, Xuan Y, Zhang Q, Chen J, Zhu W, Zhang H, Duan Y
Journal of inflammation research 2025;18:10061-10079
Journal of inflammation research 2025;18:10061-10079
Ferroptosis-related genes as prognostic markers for survival and immunotherapy in triple-negative breast cancer: analysis of public databases and a single institution.
Xie Y, Tao Z, Wang B, Zhao Y, Chen X, Li B, Wang J, Chen G, Hu X
Therapeutic advances in medical oncology 2025;17:17588359251322291
Therapeutic advances in medical oncology 2025;17:17588359251322291
Resveratrol Induces Oxidative Stress and Downregulates GPX4 and xCT to Activate the Ferroptosis Pathway for Anti-Bladder Cancer Organoids.
Chen X, Lu JL, Li H, Liu GY, Li TT, Xiao KH, Ye HS, Li S, Chen X, Liu J
Journal of Cancer 2025;16(8):2613-2625
Journal of Cancer 2025;16(8):2613-2625
Ursolic Acid induces ferroptosis by affecting redox balance and FADS2-mediated unsaturated fatty acid synthesis in Non-Small Cell Lung Cancer.
Yang L, Fang Y, Wang Y, Luo Y, Pan Y, Wu J, Li Y
Journal of Cancer 2025;16(8):2553-2566
Journal of Cancer 2025;16(8):2553-2566
Farrerol inhibits ferroptosis and protects against LPS-induced acute lung injury by targeting the RUNX1/SLC7A11 axis.
Yang Y, Deng S, Liu T, Yin Q, Yang M, Zhang X, Jiang Z, Wang X, Zhang S, Zhang T, Wu D, Xu Y
Frontiers in immunology 2025;16:1720843
Frontiers in immunology 2025;16:1720843
Radiation-induced eCIRP causes macrophage phagocytic dysfunction via mitochondrial impairment and ferroptosis.
Zhou M, Ma G, Li J, Yamaga S, Brenner M, Aziz M, Wang P
Frontiers in immunology 2025;16:1719613
Frontiers in immunology 2025;16:1719613
Integrated network pharmacology and experimental verification to reveal the mechanisms of curcumin in the treatment of colorectal cancer.
Yuan Z, Hu J, Cai C, Liu F, Chen H, Zeng B
Frontiers in pharmacology 2025;16:1703562
Frontiers in pharmacology 2025;16:1703562
Integrating network analysis and experimental validation to reveal the ferroptosis-associated mechanism of acteoside in the treatment of diabetic nephropathy.
Luo Z, Zhang SJ, Tang JY, Deng Y, Kang Y, Zhang XH, Lu HM, Wang YX, Liu WJ, Ma Y
Frontiers in pharmacology 2025;16:1660227
Frontiers in pharmacology 2025;16:1660227
Machine learning integration with multi-omics data constructs a robust prognostic model and identifies PTGES3 as a therapeutic target for precision oncology in lung adenocarcinoma.
Ruan LJ, Weng KQ, Zhang WY, Zhuang YN, Li J, Lin LM, Chen YT, Zeng YM
Frontiers in immunology 2025;16:1651270
Frontiers in immunology 2025;16:1651270
Sarsasapogenin protects hair cells from cisplatin-induced ototoxicity by attenuating apoptosis and ferroptosis via alleviating oxidative stress.
Chen Z, Xie T, Chen C, Lin T, Wu X, Chen Y, Lin Y, Luo X, Zeng C, Lin C
Frontiers in pharmacology 2025;16:1641174
Frontiers in pharmacology 2025;16:1641174
Synergistic effect of regorafenib with aminoglycosides in ferroptosis-mediated liver injury.
Raja Dahar M, Zhou S, Hu H, Lei J, Zeng K, Yu L
Frontiers in pharmacology 2025;16:1586578
Frontiers in pharmacology 2025;16:1586578
Licochalcone D mitigates intracerebral hemorrhage-induced ferroptosis of neurons through COX2 inhibition.
Song J, Qiao H, Dong S, Tang J, Li B, Zhou X, Lv S, Lv R
Frontiers in pharmacology 2025;16:1566724
Frontiers in pharmacology 2025;16:1566724
Stimulation of regulatory dendritic cells suppresses cytotoxic T cell function and alleviates DEN-induced liver injury, fibrosis and hepatocellular carcinoma.
Wang J, Gong P, Liu Q, Wang M, Wu D, Li M, Zheng S, Wang H, Long Q
Frontiers in immunology 2025;16:1565486
Frontiers in immunology 2025;16:1565486
CircASH1L inhibits ferroptosis and enhances cisplatin resistance by sponging miR-515-5p to regulate cell cycle-related CDCA7/RRM2 in ovarian cancer cells.
Feng L, Zou X, Tang L, Yuan Y, He T, Su B, Tang Y, Wang J, Liu K, Li J
Frontiers in pharmacology 2025;16:1563869
Frontiers in pharmacology 2025;16:1563869
Pachymic acid alleviates metabolic dysfunction-associated steatotic liver disease by inhibiting ferroptosis through PPARα.
Ren G, Lin Y, Qiu J, Zhang C, Chen L, Zhu L, Fan X, Dou X, Liu Q
Frontiers in pharmacology 2025;16:1554850
Frontiers in pharmacology 2025;16:1554850
Pan-cancer analysis reveals MTTP as a prognostic and immunotherapeutic biomarker in human tumors.
Wang W, Gao Y, Liu Y, Xia S, Xu J, Qin L, Jia Y, Qin Y
Frontiers in immunology 2025;16:1549965
Frontiers in immunology 2025;16:1549965
Asperosaponin VI suppresses ferroptosis in chondrocytes and ameliorates osteoarthritis by modulating the Nrf2/GPX4/HO-1 signaling pathway.
Zhang Z, Yuan D, Jin X, Chang W, Zhang Y, Xie W
Frontiers in pharmacology 2025;16:1539092
Frontiers in pharmacology 2025;16:1539092
Semaglutide attenuates myocardial ischemia-reperfusion injury by inhibiting ferroptosis of cardiomyocytes via activation of PKC-S100A9 axis.
Liu Y, Li Z, Xu X, Zou Y, Zhang M, Chen Y, Zhu W, Han B
Frontiers in pharmacology 2025;16:1529652
Frontiers in pharmacology 2025;16:1529652
Ferulic acid inhibits ox-LDL-induced ferroptosis and apoptosis in RAW 264.7 cells via the HIF-1 signaling pathway.
Wu X, Pan X, Kang J, Huang Y, Ren J, Pan J, Yu K, Li Y
Frontiers in pharmacology 2025;16:1524736
Frontiers in pharmacology 2025;16:1524736
Berbamine attenuates hind limb ischemia-reperfusion injury by eliminating lipid ROS and inhibiting p65 nuclear translocation.
Zheng L, Zhao B, Ji R, Zhang Z, Liu Y, Zhao X, Cai J, Qiao T
Frontiers in pharmacology 2025;16:1509860
Frontiers in pharmacology 2025;16:1509860
Gallic acid protects intervertebral disc cells from ferroptosis and alleviates intervertebral disc degeneration by regulating key factors of oxidative stress.
Zhu Z, Huang Z, Zhang C, Xu B, Chen H, Pei S, Zhang B, Jie L, Shi X, Liu Y, Li Y, Shen X
Frontiers in pharmacology 2025;16:1501725
Frontiers in pharmacology 2025;16:1501725
Bioactive natural alkaloid 6-Methoxydihydrosanguinarine exerts anti-tumor effects in hepatocellular carcinoma cells via ferroptosis.
Han L, Gao C, Jin X, Li Y, Chen L, Li D, Deng Q, Bian X
Frontiers in pharmacology 2025;16:1500461
Frontiers in pharmacology 2025;16:1500461
The contrasting regulatory effects of valproic acid on ferroptosis and disulfidptosis in hepatocellular carcinoma.
Liu R, Li X, Xu J, Yan L, Hu K, Shi M, Zhang Y, Zhao Y, Fan Y, Wang G, Guo Y, Feng Y, Liu P
Theranostics 2025;15(17):9091-9113
Theranostics 2025;15(17):9091-9113
Oxidative stress-mediated PANoptosis and ferroptosis: Exploration of multimodal cell death triggered by an AIE-active nano-photosensitizer via photodynamic therapy.
Wang Y, Chai C, Lin W, Cao J, Li Z, Jin Y, Xu Y, Zhang J, Qu Y, Zhan J, Zhao T, Chen Y, Gao M, Huang C, Li M
Theranostics 2025;15(14):6665-6685
Theranostics 2025;15(14):6665-6685
Ferroptosis's Master Switch GPX4 emerges as universal biomarker for precision immunotherapy: a pan-cancer study with in vitro experiments validation.
Li X, Zhu M, Dong R
Frontiers in oncology 2025;15:1643235
Frontiers in oncology 2025;15:1643235
Securinine, a novel alkaloid, regulates cell cycle and EMT in gastric cancer by inducing iron-dependent cell death.
Yuan W, Song H, Shi Y, Han J, Jiao S, Liang S, Xu Y, Jiang Y, Ji Y, Chen Z, Liu L, Xu A, Xu Z
Frontiers in oncology 2025;15:1599680
Frontiers in oncology 2025;15:1599680
Gypensapogenin I alleviates PANoptosis, ferroptosis, and oxidative stress in myocardial ischemic-reperfusion injury by targeting the NOX2/AMPK pathway.
Chen Y, Guan B, Lu J, Yan X, Huang C, Qiu Y, Li X, Sun X, Chen L, Li W, Mao W, Sun Z, Xu B, Li S, Chen C
Frontiers in cell and developmental biology 2025;13:1623846
Frontiers in cell and developmental biology 2025;13:1623846
Methylglyoxal induces oxidative stress and ferroptosis of renal tubular epithelial cells in acute and chronic kidney injury mice.
Zhang Y, Zhang X, Ren J, Sun H, Yang Z, Wang J
Frontiers in cell and developmental biology 2025;13:1604575
Frontiers in cell and developmental biology 2025;13:1604575
Jianpi Yangzheng Xiaozheng granule induced ferroptosis to suppress gastric cancer progression through reprogramming lipid metabolism via SCD1/Wnt/β-catenin axis.
Wang X, Li J, Qin R, Yin Y, Li J, Lin S, Zou X
Frontiers in molecular biosciences 2025;12:1523494
Frontiers in molecular biosciences 2025;12:1523494
Hsp90 C-terminal domain inhibition enhances ferroptosis by disrupting GPX4-VDAC1 interaction to increase HMOX1 release from oligomerized VDAC1 channels.
Li J, Wu G, Su H, Liang M, Cen S, Liao Y, Zhou X, Xie G, Deng Z, Tan W, Li Y, Xiao W, Liu L, Zhang J, Zheng Z, Deng Y, Huang Y, Shi X, Liu Y, Zhang G, Chen X
Redox biology 2025 Sep;85:103672
Redox biology 2025 Sep;85:103672
Multi-omics analysis reveals the mechanism of action of Atractylodin against depression.
Bao S, Feng M, Zhang X, Xie M, Teng J
Journal of natural medicines 2025 Sep;79(5):1067-1080
Journal of natural medicines 2025 Sep;79(5):1067-1080
The role and mechanism of PGC-1α in oxLDL-induced ferroptosis of vascular endothelial cells.
Li J, He P, Zhang Y, Zhao R, Shen C, Li C, Liu W, Liu Z, Long X, Wang Y, Shi B
Atherosclerosis plus 2025 Sep;61:1-11
Atherosclerosis plus 2025 Sep;61:1-11
Oxidative stress activates YAP/TEAD1/NCOA4 axis to promote ferroptosis of endplate chondrocytes and aggravate intervertebral disc degeneration.
Wang H, Liu X, Jing X, Zhang B, Liu X, Liu X, Jia F, Su C, Wang W, Cui X
Journal of orthopaedic translation 2025 Sep;54:8-25
Journal of orthopaedic translation 2025 Sep;54:8-25
Microplastic exposure induces preeclampsia-like symptoms via HIF-1α/TFRC-mediated ferroptosis in placental trophoblast cells.
Jia H, Liu S, Wang W, He P, Zhao F, Xu X
Toxicology 2025 Sep;516:154197
Toxicology 2025 Sep;516:154197
Changes of N6-methyladenosine and ferroptosis in cadmium-induced reproductive toxicity of male mice fed a high fat and high sugar diet.
Liu D, Zhao Y, Dai J, Li R, Yuan J, Shen K, He Z, Gu S
Toxicology 2025 Sep;516:154172
Toxicology 2025 Sep;516:154172
Gallium maltolate and cisplatin co-treatment effectively targets triple-negative breast cancer in spheroid and mouse models.
Yang YW, Hsieh YC, Liu CY, Pan CK, Pan ZY, Lo KY
Toxicology and applied pharmacology 2025 Sep;502:117460
Toxicology and applied pharmacology 2025 Sep;502:117460
Introduced paeoniflorin reduces the main toxicity induced by diosbulbin B, the major toxic compound of Dioscorea bulbifera L.: involved inhibiting inflammation and ferroptosis.
Zhang T, Li B, Wang J, Wu X, Song L, Wang Y, Zhang Y, Li Y
Drug and chemical toxicology 2025 Sep;48(5):1080-1089
Drug and chemical toxicology 2025 Sep;48(5):1080-1089
Complexin 2 contributes to the protective effect of NAD(+) on neuronal survival following neonatal hypoxia-ischemia.
Xu XW, Zhou XW, Zhang L, Wang Q, Wang XX, Jin YM, Li LL, Jin MF, Wu HY, Ding X, Ni H
Acta pharmacologica Sinica 2025 Sep;46(9):2363-2375
Acta pharmacologica Sinica 2025 Sep;46(9):2363-2375
Exploring the potential mechanism of atorvastatin in regulating ferroptosis as a treatment for heart failure based on network pharmacology.
Bai YT, Wang YQ, Liu YM, Gong ZX, Wugeng S, Guo WL, Shi MZ, Liu XQ, Su XL
Naunyn-Schmiedeberg's archives of pharmacology 2025 Sep;398(9):12227-12239
Naunyn-Schmiedeberg's archives of pharmacology 2025 Sep;398(9):12227-12239
Brucine Inhibits Gastric Cancer via Activation of Ferroptosis Through Regulating the NF-κB Signaling Pathway.
Zhang B, Yu C, Zhang S, Zhang M
Journal of biochemical and molecular toxicology 2025 Sep;39(9):e70479
Journal of biochemical and molecular toxicology 2025 Sep;39(9):e70479
Embelin Mitigates the Impact of Perinatal Inflammation on Neuron Development by Inhibiting 5-Lipoxygenase-Mediated Ferroptosis.
Zhang F, Sun M, Ma S, Sun J, Li Y, Li X, Jiang H
Phytotherapy research : PTR 2025 Sep;39(9):4060-4080
Phytotherapy research : PTR 2025 Sep;39(9):4060-4080
Proanthocyanidin B2 Alleviates Cuprizone-Induced Demyelination by Regulating the Astrocytic xCT/GSH/GPX4 Axis.
Liu J, Hou YX, Chen Y, Liang YJ, Pu M, Zheng LL, Zhang ZW, Xiao Y, Mao Z, Ma CG, Wang Q
CNS neuroscience & therapeutics 2025 Sep;31(9):e70598
CNS neuroscience & therapeutics 2025 Sep;31(9):e70598
PTBP1 acts as a tumor suppressor in glioma by promoting HMOX1-dependent ferroptosis.
Sun J, Xue B, Sun T, Xu X, Zhang D, Shan Z, Wang Y, Chen B
Biochemical pharmacology 2025 Sep;239:117041
Biochemical pharmacology 2025 Sep;239:117041
Intratumor microbiome-derived butyrate enhances progesterone sensitivity by inducing ferroptosis in endometrial cancer.
Li X, Wang Y, Wu Y, Wang J, Qi Y, Bi X, Wang J
Pharmacological research 2025 Sep;219:107902
Pharmacological research 2025 Sep;219:107902
Atp7a deficiency induces axonal and myelin developmental defects in zebrafish via ferroptosis.
Wu Y, Li J, Zhai W, Liu W, Wu H, Liu H, Min J, Wang F, Liu JX
Neurobiology of disease 2025 Sep;213:107027
Neurobiology of disease 2025 Sep;213:107027
LncRNA 91234.1 targets PRMT1/ASCL4/GPX4 axis to regulate formaldehyde-induced cardiomyocyte ferroptosis and congenital heart disease.
Zhao S, Sun P, Wang C, Li X, Xiu Z, Tian Y, Song X, He X, Yu T, Jiang Z
Journal of molecular and cellular cardiology 2025 Sep;206:76-90
Journal of molecular and cellular cardiology 2025 Sep;206:76-90
Placental Ferroptosis May Be Involved in Prenatal Arsenic Exposure Induced Cognitive Impairment in Offspring.
Li M, Hu Y, Wu X, Tong J, Tao J, Tang A, Ji Y, Yao Y, Tao F, Liang C
Biological trace element research 2025 Sep;203(9):4543-4560
Biological trace element research 2025 Sep;203(9):4543-4560
Unraveling the molecular mechanisms of paraquat toxicity: The interplay of ATF4, ferroptosis, and endoplasmic reticulum stress.
Ke J, Cai Q, Ge X, Zhang S
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Sep;203:115602
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Sep;203:115602
Activation of Rab7-mediated lipophagy is required for triptolide to induce ferroptosis in hepatic cells.
Liu S, Su Y, Han B, Yin L, Li H, Wang Y, Zhou K, Li P, Wei Y
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Sep;203:115568
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Sep;203:115568
Discovery of 8-hydroxy-tetrahydroquinoline ferroptosis inhibitors for the treatment of acute kidney injury.
Sheng XH, Teng LS, Meng XS, Song YH, Liu ZH, Sun JW, Wu DF, Ma JP, Zhang L
Bioorganic chemistry 2025 Sep;164:108874
Bioorganic chemistry 2025 Sep;164:108874
An SPR-based active ingredient recognition strategy for identifying PLK1-targeting withanolides as natural ferroptosis inducers.
Zhu R, Yan H, Xu W, Liang J, Xiang K, Liu Y, Yang Y, Li H, Chen L
Bioorganic chemistry 2025 Sep;164:108849
Bioorganic chemistry 2025 Sep;164:108849
Taraxerol induces ferroptosis in breast cancer by targeting Nrf2 transcriptional activity to promote MIB2-mediated GPX4 ubiquitination.
Du P, Han A, Liu J, Li W, Feng X, Chen L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:157024
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:157024
Formononetin enhances cisplatin chemotherapy sensitivity in osteosarcoma by inducing ferroptosis and reconstructing the immune microenvironment.
Liu Y, Xie T, Liang J, Feng W, Yang M, Li S, Xiong L, Luo K, Li F, Tang S, Liu S, Huang Q, Tang H, Tang F, Wei Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:156960
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:156960
USP10 Inhibits Ferroptosis via Deubiquinating POLR2A in Head and Neck Squamous Cell Carcinoma.
Zhang D, Wang X, Lu S, Gao Y, Zhu G, Li G, Yu Z, Hou J, Yan H, Yuan W, Zhang X, Hung MC, Liu Z, Liu Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(36):e12271
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(36):e12271
TMAO regulates OTUB1-mediated SLC7A11 stability to promote NAFLD progression.
Zhong B, Zhu Q, Wei P, Wang X
Biochemical and biophysical research communications 2025 Sep 8;778:152352
Biochemical and biophysical research communications 2025 Sep 8;778:152352
FGF5 alleviates ferroptosis in renal tubular epithelial cells by inducing mitophagy under in vitro ischemia-reperfusion-like injury.
Lin D, Wu T, Huang H, Hong X
Journal of molecular histology 2025 Sep 6;56(5):299
Journal of molecular histology 2025 Sep 6;56(5):299
Crotonoside induces ferroptosis and mitochondrial dysfunction in AML.
Ma C, Wang J, Cui S, Xu R
European journal of pharmacology 2025 Sep 5;1002:177859
European journal of pharmacology 2025 Sep 5;1002:177859
Baicalein suppresses the malignant progression of acute myeloid leukemia via ROS-dependent metabolic reprogramming: Mechanisms of differentiation induction and ferroptosis activation.
Wang M, Wang Y, Chen L, Yu S, Li X, Huang G, Jin M
European journal of pharmacology 2025 Sep 5;1002:177839
European journal of pharmacology 2025 Sep 5;1002:177839
Coelenterazine alleviates sepsis-associated acute kidney injury by inhibiting ferroptosis via the USP14-NCOA4 pathway.
Bao D, Sha X, Zhao C, Xie X, Lai Y, Liu L, Fan R, Huang W, Zhang Y, Wu G, Ye D, Li H, Lai C
Translational andrology and urology 2025 Sep 30;14(9):2606-2621
Translational andrology and urology 2025 Sep 30;14(9):2606-2621
Eucommia ulmoides (Duzhong) extract alleviates cerebral stroke by inhibiting ferroptosis-related gene DNA Damage-Inducible Transcript 4 (DDIT4) expression.
Qi X, Deng M, Li M, Ma W, Zhou Y
Human cell 2025 Sep 29;38(6):166
Human cell 2025 Sep 29;38(6):166
BRD-K20733377 inhibits ferroptosis and alleviates intervertebral disc degeneration via the STAT3/NFKB1 axis: a multiapproach study.
Sun H, You X, Li Z, Li Z, Hua B, Liu C, Zhang Y, Wu H, Zai S, Zhang L
Stem cell research & therapy 2025 Sep 29;16(1):531
Stem cell research & therapy 2025 Sep 29;16(1):531
Zingerone treats postmenopausal osteoporosis via increased ferroptosis sensitivity by p53-mediated regulation of SAT1 and GPX4 expression.
Li H, Cao F, Liu D, Tao L
Communications biology 2025 Sep 26;8(1):1367
Communications biology 2025 Sep 26;8(1):1367
Protecting the brain from stroke: Huoxue Rongluo formula (HXRLF) targets ferroptosis for neuroprotection.
Ma Q, Luo L, Liao Y, Yang R, Ouyang X, Zhang Y, Yan S, Gong C, Liu L, Zhou D
Journal of ethnopharmacology 2025 Sep 25;353(Pt A):120329
Journal of ethnopharmacology 2025 Sep 25;353(Pt A):120329
Dovitinib Ameliorates Inflammation-Related Diseases by Inhibiting Necroptosis and Ferroptosis.
Lin Y, Feng J, Zhao M, Zhang L, Li Y, Chen X, Lin C, Lin J, Lin Q, Li J, Wu L, Li L
ACS chemical biology 2025 Sep 19;20(9):2191-2203
ACS chemical biology 2025 Sep 19;20(9):2191-2203
Protective Effect of Hepcidin on Sepsis-Associated Acute Kidney Injury via Activating the Nrf2/GPX4 Signaling Pathway.
Guo LB, Wu SS, Xu F, Chen XX, Fan H
Current issues in molecular biology 2025 Sep 18;47(9)
Current issues in molecular biology 2025 Sep 18;47(9)
Farrerol ameliorates diabetic cardiomyopathy by inhibiting ferroptosis via miR-29b-3p/SIRT1 signaling pathway in endothelial cells.
Guo Y, Yu XR, Gu HD, Wang YJ, Yang ZG, Chi JF, Zhang LP, Lin H
World journal of diabetes 2025 Sep 15;16(9):109553
World journal of diabetes 2025 Sep 15;16(9):109553
Entospletinib alleviates acute liver injury and acute kidney injury by inhibiting ferroptosis.
Zhao M, Lin Y, Zeng Q, Li Y, Feng J, Chen X, Lin C, Zhang L, Zhong Y, Lin J, Lin Q, Li J, Wu L, Liu X, Li L
European journal of pharmacology 2025 Sep 15;1003:177939
European journal of pharmacology 2025 Sep 15;1003:177939
Osteoblast ferroptosis driven by iron overload: Implications for osteoporosis pathogenesis and FTH1/GPX4-targeted therapy.
Wan S, He Y, Chong B, Xia Z, Qiu Y, Zhang R, Hu M, An Z, Li Y, Xie J, Li S
Biochemical and biophysical research communications 2025 Sep 12;779:152439
Biochemical and biophysical research communications 2025 Sep 12;779:152439
Lead binds HIF-1α contributing to depression-like behaviour through modulating mitochondria-associated astrocyte ferroptosis.
Shi F, Wang Y, Hao H, Zhao Y, Wu F, Ge Y, Liu SC, Liu P, Wang W, Zhang Y
Communications biology 2025 Sep 11;8(1):1342
Communications biology 2025 Sep 11;8(1):1342
Zearalenone induces intestinal damage and flora disturbance in rats by triggering ferroptosis via the system Xc(-)-GSH-GPX4 signaling pathway.
Huangfu B, Li J, Xu T, Ren X, Zhang R, Chen Y, Wang J, Huang K, He X
Ecotoxicology and environmental safety 2025 Sep 1;302:118600
Ecotoxicology and environmental safety 2025 Sep 1;302:118600
Houttuynia cordata Thunb-derived extracellular vesicle-like particles alleviate ischemic brain injury by miR159a targeting ACSL4 to suppress ferroptosis.
Zhang S, Liang Z, Wu C, Qin Z, Wei X, Liu Y, Su R, Li L, Sun B, Huang L, Wang W, Shen J, Wang G, Qi S
Chinese medicine 2025 Sep 1;20(1):141
Chinese medicine 2025 Sep 1;20(1):141
Glycyrrhizic Acid Ameliorates LPS-Induced WI-38 Cell Inflammation, Oxidative Stress, and Ferroptosis via Targeting METTL14 in Infantile Pneumonia.
Xie X, Wang C, Sun Y, Sun T, Song Y, Wang N, Wang Z, Wang Y
Clinical and experimental pharmacology & physiology 2025 Oct;52(10):e70068
Clinical and experimental pharmacology & physiology 2025 Oct;52(10):e70068
4-Octyl Itaconate Attenuates Postmenopausal Osteoporosis by Inhibiting Ferroptosis and Enhancing Osteogenesis via the Nrf2 Pathway.
Li Y, Li Y, Li P, Yang L, Li H
Inflammation 2025 Oct;48(5):3326-3339
Inflammation 2025 Oct;48(5):3326-3339
Reprogramming Iron Metabolism via the RIG-I/c-Myc/FTH Axis Mitigates Renal Ischemia-Reperfusion Injury.
Zhang Y, Xing J, Yao L, Zou Y, Peng H, Yi X, Bai L, Yu Y, Liu H, Li X, Zhai X
Antioxidants & redox signaling 2025 Oct;43(10-12):622-636
Antioxidants & redox signaling 2025 Oct;43(10-12):622-636
Ferritinophagy Is Involved in the Advanced Glycation End Products-Induced Ferroptosis of Vascular Endothelial Cells in Diabetes Mellitus.
Huang Y, Jin Y, Hu J, Li M, Tian M, Zeng G, Huang R
Journal of cellular and molecular medicine 2025 Oct;29(20):e70857
Journal of cellular and molecular medicine 2025 Oct;29(20):e70857
Centipede Polypeptide Affects the Inflammatory Reaction and Ferroptosis of Liver Cancer Cells Through the p53/TRAIL Pathway.
Xing X, Lu L, Huang Z, Wang J, Wang L, Hu Y, Yin S, Tian S
Journal of cellular and molecular medicine 2025 Oct;29(19):e70844
Journal of cellular and molecular medicine 2025 Oct;29(19):e70844
Berberine inhibits high glucose-induced ferroptosis in retinal vascular endothelial cells: Mechanism and implications.
Chen J, Peng W, Yang W, You Z, Zou Y
Experimental eye research 2025 Oct;259:110531
Experimental eye research 2025 Oct;259:110531
3D printed GelMA/HAMA based mechanical microenvironment boosted PDAC chemoresistance via NRF2-repressed ferroptosis.
Yan J, Wu D, Zhu B, Guan X, Zhang X, Guo Y, Lu Y
Colloids and surfaces. B, Biointerfaces 2025 Oct;254:114816
Colloids and surfaces. B, Biointerfaces 2025 Oct;254:114816
RTA-408 overcomes cisplatin-resistant lung cancer by inhibiting WWP1-mediated NCOA4 ubiquitination to induce ferritinophagy and ferroptosis.
Wang X, Liu T, Fei Y, Zhang S, Yang Y, Chen Z, Zhu R, Deng S, Zhang T, Wu D, Xu Y
Free radical biology & medicine 2025 Oct;238:595-610
Free radical biology & medicine 2025 Oct;238:595-610
Panx3 mediates ferroptosis via the AKT/mTOR signaling pathway in oral squamous cell carcinoma.
Li X, Zhao Y, Liu Y, Zhang CS, Xu ZY, Wang SR, Zhang TM, Zhang Y, Liang SX, Yan YB
Cellular signalling 2025 Oct;134:111908
Cellular signalling 2025 Oct;134:111908
PIEZO1-GPX4 Axis Mediates Mechanical Stress-Induced Vertebral Growth Plate Dysplasia via Ferroptosis Activation.
Chen F, Peng F, Chen S, Du Y, Li J, Fan Y, Cui Z, Gu G, Zhang H, Jiang Z, Wang G, Jing X, Dong J, Li T, Xi Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(39):e02052
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(39):e02052
Adaptive Antioxidant Nanomedicines Inhibit Ferroptosis in Renal Tubular Epithelial Cells to Alleviate Diabetic Kidney Disease.
Liu Z, Huang T, Hong Y, Yang Y, Chen W, Zeng Q, Chen Q, Yang Y, Ying X, Zeng W, Wu Z, Zhao T, Wan X, Chen J, Ai K, Huang Q
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(37):e05168
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(37):e05168
SLC25A10 promotes cisplatin resistance by inhibiting ferroptosis in cervical cancer.
Ma C, Lu X, Ni C, Gao Y, Yang F, Chen S, Du Y, Zhao F, Cao Y, Huang H
Cell death discovery 2025 Oct 7;11(1):447
Cell death discovery 2025 Oct 7;11(1):447
Ferroptosis-Enhanced Radiopharmaceutical Therapy via a Manganese-Based Nanoplatform.
Zhu Z, Yang B, Wang K, Li Y, Zhu K, Gao H, Ma H, Shao F, Li F, An R, Liu N, Zhang W
Molecular pharmaceutics 2025 Oct 6;22(10):6215-6227
Molecular pharmaceutics 2025 Oct 6;22(10):6215-6227
Microwave dynamic therapy induces ferroptosis in colorectal cancer by targeting PTK2B to regulate STAT3-mediated GPX4 expression.
Zhou H, Zhang Z, Liu Z, Xiong L, Ran X, Liu J, Ran Y, Wen Y, Chen W, Xu J
Molecular biomedicine 2025 Oct 30;6(1):91
Molecular biomedicine 2025 Oct 30;6(1):91
Lipid peroxidation and type I interferon coupling fuels pathogenic macrophage activation causing tuberculosis susceptibility.
Yabaji SM, Zhernovkov V, Araveti PB, Lata S, Rukhlenko OS, Abdullatif SA, Vanvalkenburg A, Alekseyev YO, Ma Q, Dayama G, Lau NC, Johnson WE, Bishai WR, Crossland NA, Campbell JD, Kholodenko BN, Gimelbrant AA, Kobzik L, Kramnik I
eLife 2025 Oct 2;14
eLife 2025 Oct 2;14
Fe-doped phase-transition nanodroplets for synergistic photothermal and starvation-enhanced ferroptosis in cancer therapy.
Tian Y, He X, Yuan Y, Wang C, Zhang M, Jiang H, Yang H, Yang K, Jing H
Journal of nanobiotechnology 2025 Oct 16;23(1):684
Journal of nanobiotechnology 2025 Oct 16;23(1):684
Exocarpium Citri Grandis ameliorates alcoholic liver disease by modulation of hepatic lipid metabolism and iron homeostasis.
Li YJ, Zhang YX, Xu S, Qin MC, Deng GH, Li JJ, Shen XF, Guo H, Liao YX, Zhou CY, Huang SH, Liu MH, Zhao WX, Gao L
Chinese medicine 2025 Oct 16;20(1):174
Chinese medicine 2025 Oct 16;20(1):174
Integrated Multiomic Analysis Reveals the Therapeutic Potential of Danhong Injection in Mitigating Radiation-Induced Heart Disease by Modulating Ferroptosis.
Wang BW, Wang G, Zhang Z, Lu WJ, Li YL, Shu YB, Xie P
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Oct 15;39(19):e71106
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Oct 15;39(19):e71106
Liraglutide attenuates doxorubicin-induced cardiomyocyte ferroptosis via DHHC7-mediated STAT3 palmitoylation.
Gao G, Shen C, Wang M, Ji C, Fang F, Jiang Y, Shi L, Chen W, Zhang J
Life sciences 2025 Oct 15;379:123912
Life sciences 2025 Oct 15;379:123912
Human amniotic mesenchymal stem cell-derived exosome inhibits ferroptosis through the suppression of JNK/MAPK-mediated EGR1 expression in spontaneous intracerebral hemorrhage.
Wang Y, Zhou L, Xu K
Brain research bulletin 2025 Oct 15;231:111553
Brain research bulletin 2025 Oct 15;231:111553
P2X7R activation promotes ferroptosis in dopaminergic neurons via NF-κB signaling pathway in vitro and in vivo models of MPP(+)/MPTP-induced Parkinson's disease.
Si Y, Yan S, Li X, Ding W, Zhang X, Jia K, Yao L, Yang F, Shi W
Brain research 2025 Oct 15;1865:149824
Brain research 2025 Oct 15;1865:149824
Analysis of the Correlation Between Depression-like Behaviors and Lipid Peroxidation in the Prefrontal Cortex of Mice: The Impact of Early Life Stress.
Mi X, Ye ZL, Zhang XJ, Dai XM, Luo ZS
Brain sciences 2025 Oct 15;15(10)
Brain sciences 2025 Oct 15;15(10)
Ginsenoside Rb3 modulates gut microbiota to alleviate cerebral inflammation and ferroptosis via the NLRP3/NF-κB/GPX4 pathway in rats with cerebral ischemia/reperfusion injury.
Xie X, Ge W, Luo Y, Xing X, Sun X
European journal of pharmacology 2025 Oct 15;1005:178091
European journal of pharmacology 2025 Oct 15;1005:178091
SAP30BP aggravates mitochondrial-related ferroptosis in diabetic cardiomyopathy by regulating MFN2-ACSL4 axis.
Zhao T, Chen C, Zhao W, Han J, Omar Jan M, Lou H, Chen Z, Liu X, Jing S
European journal of pharmacology 2025 Oct 15;1005:178046
European journal of pharmacology 2025 Oct 15;1005:178046
FASN inhibits ferroptosis in breast cancer via USP5 palmitoylation-dependent regulation of GPX4 deubiquitination.
Qian Z, Jiang Y, Cai Y, Gao E, Wang C, Dong J, Wang F, Liu L, Wu D, Zhang F, Wang Y, Ning X, Li Q, You Y, Gu Y, Mei J, Zhao X, Zhang Y
Journal of experimental & clinical cancer research : CR 2025 Oct 14;44(1):289
Journal of experimental & clinical cancer research : CR 2025 Oct 14;44(1):289
PK11007 Covalently Inhibits Thioredoxin Reductase 1 to Induce Oxidative Stress and Autophagy Impairment in NSCLC Cells.
Zhou H, Sun S, Liu H, Li T, Xu Y, Yang R, Liu H, He L, Xu W, Guan S, Xu J
Antioxidants (Basel, Switzerland) 2025 Oct 11;14(10)
Antioxidants (Basel, Switzerland) 2025 Oct 11;14(10)
Blood flow restriction training attenuates stroke-induced hippocampal ferroptosis, synaptic damage, and cognitive impairment via upregulating SIRT1 pathway.
Zhou F, Zhu X, Zhang X, Lin C, Ma Y, Lin Q, Li X
Neuroscience 2025 Oct 1;584:295-310
Neuroscience 2025 Oct 1;584:295-310
Mechanistic insights into the renoprotective effects of artesunate in cisplatin-induced acute kidney injury.
Chen H, Guo R, Zhang C, Zhang L, Hu H, Du P, Duan J, Chen L, Ma X, Xue J, Mao Y, Jiang T
Life sciences 2025 Oct 1;378:123820
Life sciences 2025 Oct 1;378:123820
MINPP1 promotes ferroptosis in HBV-related hepatocellular carcinoma by regulating CTSB K33-linked deubiquitination via ZRANB1.
Chen W, Song Y, Wang L, Xiong F, Zhang S
Biology direct 2025 Oct 1;20(1):100
Biology direct 2025 Oct 1;20(1):100
METTL3-mediated m6A modification promotes ferroptosis in adenomyosis through GPX4 in a YTHDF1-dependent manner.
Tang Y, Li Z, Zhao X, Niu X, Ning S, Liu L, Liu Z, Zhang J, Zhao Q, Han L
Reproduction (Cambridge, England) 2025 Oct 1;170(4)
Reproduction (Cambridge, England) 2025 Oct 1;170(4)
Targeting SIRT3 to regulate mitophagy-dependent ferroptosis for preventing glucocorticoid-induced osteoporosis.
Hu Y, Lu H, Fang H, Chen B, Chen Z, Jiang M, Zhou Y, Li Z, Gao S, Huang Z, Zhou C, Liu Y, Chen Z, Fan Y
International journal of surgery (London, England) 2025 Oct 1;111(10):6647-6662
International journal of surgery (London, England) 2025 Oct 1;111(10):6647-6662
TRIM39-mediated deubiquitination upregulates RNF168 to evade autophagy-ferroptosis in triple-negative breast cancer.
Yao X, Shen X, Fan Y, Wang H
NPJ breast cancer 2025 Oct 1;11(1):108
NPJ breast cancer 2025 Oct 1;11(1):108
Inhibition of ferroptosis by serine protease inhibitor attenuates acute respiratory distress syndrome.
Guo Q, Gao X, Ren J, Deng G, Li R, Zhang C, Xu X, Li J, Liu W, Qin L, Wang G
Archives of biochemistry and biophysics 2025 Nov;773:110596
Archives of biochemistry and biophysics 2025 Nov;773:110596
Targeting ZNRF2-mediated SLC3A2 plasma membrane translocation enhances ferroptosis in lung adenocarcinoma.
Zhang W, Li J, Zhao J, Lu D, Zhang M, Ma C, Yang Y, Gu L, Zhu J, Zeng Y, Huang JA, Liu Z
Oncogene 2025 Nov;44(45):4339-4351
Oncogene 2025 Nov;44(45):4339-4351
ML385 increases ferroptosis via inhibiting Nrf2/HO-1 pathway to enhances the sensitivity of MCF-7 TAMR to tamoxifen.
Yuan J, Huang W, Lin M, Sun S, Zhong F, Ye L, Yin H, Ou X, Zeng Z
Naunyn-Schmiedeberg's archives of pharmacology 2025 Nov;398(11):16081-16093
Naunyn-Schmiedeberg's archives of pharmacology 2025 Nov;398(11):16081-16093
NDUFA8 promotes cell viability and inhibits ferroptosis and cisplatin sensitivity by stabilizing Fe-S clusters in cervical cancer.
Xiang H, Sun J, Kong L, Wang Y, Qiu X, Zeng J, Li G, He J
Naunyn-Schmiedeberg's archives of pharmacology 2025 Nov;398(11):15547-15559
Naunyn-Schmiedeberg's archives of pharmacology 2025 Nov;398(11):15547-15559
Quercetin Targets HSP90α and Regulates Keap1/Nrf2 Pathway to Inhibit Crosstalk between Apoptosis and Ferroptosis in Oxidatively Stressed Neurons.
Liu J, Zhang ZZ, Yu GR, Han X
Journal of biochemical and molecular toxicology 2025 Nov;39(11):e70583
Journal of biochemical and molecular toxicology 2025 Nov;39(11):e70583
Jujuboside B Induces Ferroptosis and Overcomes Radioresistance Through the PPARγ-ATF3-Gpx4 Signaling Pathway in Non-Small Cell Lung Cancer.
Kim TW, Ko SG
Phytotherapy research : PTR 2025 Nov;39(11):5345-5364
Phytotherapy research : PTR 2025 Nov;39(11):5345-5364
Structural characterization and functional role of SLC7A6 in GSSG transport and Ferroptosis regulation.
Yan G, Chen M, Lu Z, Huang H, Wang X, Qin W, Mo S, Zhong P, Han C, Ye X
International journal of biological macromolecules 2025 Nov;330(Pt 3):148008
International journal of biological macromolecules 2025 Nov;330(Pt 3):148008
ARID1A loss enhances sensitivity to c-MET inhibition by dual targeting of GPX4 and iron homeostasis, inducing ferroptosis.
Zhang X, Wang Z, He Y, Wang K, Xiang C, Liu Y, Song Y, Li A, Wang Z, Yu Y, Peng W, Liu S, Shim JS, Wu C
Cell death and differentiation 2025 Nov;32(11):2009-2021
Cell death and differentiation 2025 Nov;32(11):2009-2021
Silymarin ameliorates diet-induced gallstone formation by regulating gut microbiota-derived GCDCA to suppress ferroptosis-ROS-NFκB signaling pathway.
Wang Q, Han C, Zheng Y, Liu X, Lv Z, Du Z, Liu T, Hao C, Meng X, Li T, Xue D
Free radical biology & medicine 2025 Nov;239:496-512
Free radical biology & medicine 2025 Nov;239:496-512
Deferoxamine attenuates sepsis-induced liver injury by suppressing ferroptosis.
Zhang H, Li H, Liu S, Zheng J, Li P
Immunobiology 2025 Nov;230(6):153125
Immunobiology 2025 Nov;230(6):153125
SFTSV induces liver ferroptosis through m6A-related ferritinophagy.
Liu B, Tian X, Li L, Jiang N, Cheng M, Zhu J, Wu Z
Autophagy 2025 Nov;21(11):2353-2366
Autophagy 2025 Nov;21(11):2353-2366
Mechanism and marker of voriconazole-induced liver injury: insights from a quantitative systems toxicology approach.
Du Q, Qiu Y, Yang L, Wang C, Teng M, Chen J, Luo Y, Sun J, Wang T, Chen S, Dong Y
Regulatory toxicology and pharmacology : RTP 2025 Nov;162:105871
Regulatory toxicology and pharmacology : RTP 2025 Nov;162:105871
CX-5461 inhibits cell proliferation and induces ferroptosis of colorectal cancer cells by inactivating Nrf2 pathway.
Chang X, Zhang Y, Wang Q, Yang W, Zhang R, Cong X, Xiao W, Piao J, Lin Z, Jin A
Cellular signalling 2025 Nov;135:111998
Cellular signalling 2025 Nov;135:111998
Optimized Monothiol Thioredoxin Derivative (ORP100S) Protects In Vitro and In Vivo from Radiation and Chemotoxicity Without Promoting Tumor Proliferation.
Wu J, Wang X, Mathews P, Jabbar S, Zhang M, Moskowitz H, Duan W, Nichols DP, Schaaf GW, Olson JD, Macintyre AN, Bourland JD, Spasojevic I, Chi JA, Ross J, Chao N, Cline JM, Heifetz PB, Kang Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(42):e04426
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(42):e04426
Downregulation of acetyl-CoA carboxylase induces ferroptosis and inhibits tumor growth in oral squamous cell carcinoma.
Xu Z, Jia G
Biotechnic & histochemistry : official publication of the Biological Stain Commission 2025 Nov;100(8):451-459
Biotechnic & histochemistry : official publication of the Biological Stain Commission 2025 Nov;100(8):451-459
RRM2 contributes to pathogenic phenotype of fibroblast-like synoviocytes by activating NF-κB signaling and inhibiting ferroptosis in rheumatoid arthritis.
Zhang L, Wang Z, Zheng J, Zhong Q
Journal of orthopaedic surgery and research 2025 Nov 7;20(1):976
Journal of orthopaedic surgery and research 2025 Nov 7;20(1):976
Iron addicted colorectal cancers exploit Heme-Complex II axis to resist oxidative cell death.
Jain C, Essani M, Kumar R, Das NK, Singhal R, Rossiter NJ, Chen B, Huang W, Lee ZH, Solanki S, Zhang Y, Sajjakulnukit P, Zhang L, Dalal PJ, Hanna DA, McCollum S, Stoffel EM, Greenson JK, Maher LJ, Lyssiotis CA, Banerjee R, Shah YM
bioRxiv : the preprint server for biology 2025 Nov 6;
bioRxiv : the preprint server for biology 2025 Nov 6;
Palmitic Acid Induces Ferroptosis in Retinal Microvascular Endothelial Cells by Palmitoylation of Keap1 to Affect Diabetic Retinopathy.
Mao Z, Yang W, Chao Y, Chen Z, Zou Y
Investigative ophthalmology & visual science 2025 Nov 3;66(14):41
Investigative ophthalmology & visual science 2025 Nov 3;66(14):41
Taoren Honghua Jian improves ferroptosis-mediated myocardial damage following myocardial infarction via Nrf2-dependent enhancement of GPX4/FSP1.
Zhang GY, Zhang F, Xie LP, Han X, Wang ZX, Wang WL, Peng Y, Xu HL, Xu T, Pang MJ, Liu B, Wang D, Zhou YC, Wu YT
The Journal of pharmacy and pharmacology 2025 Nov 28;77(12):1726-1741
The Journal of pharmacy and pharmacology 2025 Nov 28;77(12):1726-1741
PTBP1 functions as a suppressor of ferroptosis in endometrial carcinoma cells by stabilizing SLC7A11 mRNA.
Zhu K, Zhang K, Li H, Shen Y, Wang L, Hu Q, Xing H, Han L
Discover oncology 2025 Nov 28;16(1):2341
Discover oncology 2025 Nov 28;16(1):2341
Ferroptosis mediated by ferritinophagy is involved in liver injury caused by sepsis.
Zhang H, Li H, Liu S, Zheng J, Li P
Scientific reports 2025 Nov 27;15(1):45489
Scientific reports 2025 Nov 27;15(1):45489
Identification of Potential Key Ferroptosis-Related Genes in EV71-Infected Cells Through Bioinformatics Analysis and Experimental Study.
Zhang Y, Zhou M, Yang L, Wang J, Wen X, Shi L, Liu Y, Shi Y, Liu
Current microbiology 2025 Nov 25;83(1):40
Current microbiology 2025 Nov 25;83(1):40
Scutellarin triggers ferroptosis in ovarian cancer cells via inhibiting AKT/mTOR and JAK2/STAT3 pathways.
Wang S, Zhang M, Tang C, Xia T, Gao L, Chen Q, Gao F, Ye W, Wang H, Jin M, Jiang X, Gao L, Xu Z, Zhu R, Yan X, Zhu J, Ye Z, Yan J, Zhang G, Wang W
Medical oncology (Northwood, London, England) 2025 Nov 25;43(1):24
Medical oncology (Northwood, London, England) 2025 Nov 25;43(1):24
Self-assembled phenylboronic acid nanomedicine targets sialic acid to synergistically activate ferroptosis via RRM1 suppression and GPX4 Inhibition for precision colon cancer therapy.
Song D, Li J, Zhu Y, Hui Q, Qi H, Yu H, Chen L, Qian Y, Guo Y, Wei M, Guan Q, Li Z
Journal of nanobiotechnology 2025 Nov 25;23(1):735
Journal of nanobiotechnology 2025 Nov 25;23(1):735
Breviscapine targets EGFR and SRC to abrogate diabetes-driven GPX4 lactylation and ferroptosis resistance in gastric cancer.
Hu HM, Deng JL, Pan Y, Wang ZH, Zhang J, Yu Gu X, Fan SX, Zhao JZ
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157387
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157387
Verbascoside (VB) Inhibits Ischemic Stroke Progression via Suppression of Cell Damage and Ferroptosis By Targeting LCN2/ALOX5/SLC7A11/GPX4 Expression.
Zhang C, You J, Zhou X, Feng J, Li Q, Zhou H
Molecular neurobiology 2025 Nov 21;63(1):116
Molecular neurobiology 2025 Nov 21;63(1):116
Targeting the ROS-ferroptosis-inflammation cycle with a nanozyme-functionalized hydrogel for intervertebral disc repair.
Wang Y, Tan L, Yang Y, Duan H, Liu C, Zhao J, Zhou Y, Li C, Liu M
Nature communications 2025 Nov 20;16(1):11253
Nature communications 2025 Nov 20;16(1):11253
Targeting cancer stem-like cells via cholesterol modulation and ferroptosis induction using a multifunctional nanoplatform to overcome drug resistance.
Ye L, Zhu J, Wang X, Chen N, Sun Y, Zeng X, Liu S, Yan S
Journal of nanobiotechnology 2025 Nov 19;23(1):722
Journal of nanobiotechnology 2025 Nov 19;23(1):722
WTAP regulates NCOA4-mediated ferroptosis via a YTHDF2-dependent mechanism in preeclampsia.
Li C, Li Z, Ma C, Xu L, Zhang N, Li Y, Lv Q, Li C, Zhao S
Clinical epigenetics 2025 Nov 19;17(1):195
Clinical epigenetics 2025 Nov 19;17(1):195
FGF21-engineered ADSCs promote diabetic wound healing by mitigating ferroptosis and oxidative stress via the SIRT1/NRF2/GPX4 signaling pathway.
Liang Z, Gu Y, Li Y, Wu Z, Xu X, Wei G, Wang N, Zhang Z, Hao Q, Peng Y, Wang H, Yu Z, Song B
Stem cell research & therapy 2025 Nov 19;16(1):650
Stem cell research & therapy 2025 Nov 19;16(1):650
Molecular regulatory mechanism of the SIRT2/NF-κB p65 signaling pathway in ferroptosis-promoted spinal cord injury repair.
Shi S, Zhang Z, Huang X, Gong C, Zhao Z, Wang T, Zhou Y, Zhang M, Gao J, Shi P, Yu X
BMC neurology 2025 Nov 12;25(1):463
BMC neurology 2025 Nov 12;25(1):463
NCOA4-mediated ferroptosis conducive to EMT inhibition in colorectal cancer cells was achieved through the PI3K/AKT/mTOR pathway.
Fu Y, Zhao Q, Li Y, Sun Y, He B, Li C, Zhang W, Yin Y, Li C
Scientific reports 2025 Nov 11;15(1):39542
Scientific reports 2025 Nov 11;15(1):39542
Dietary supplementation of Chlorella pyrenoidosa attenuated non-alcoholic fatty liver disease via the NF-κB/ferroptosis axis.
Zhao T, Lu D, Qiu M, Yan B, Fu T
Food & function 2025 Nov 10;16(22):8773-8790
Food & function 2025 Nov 10;16(22):8773-8790
NRG1/PDGFC loop between fibroblasts and cancer cells drives paclitaxel resistance via ferroptosis suppression in breast cancer.
Duan WL, Wang XJ, Gu LH, Guo A, Ding YY, Lin P, Zhang BG
Cell death discovery 2025 Nov 10;11(1):520
Cell death discovery 2025 Nov 10;11(1):520
CLDND1 as a prognostic ferroptosis-associated biomarker in oral squamous cell carcinoma.
Zang X, Yan D, Liu Y, Sun X, Zhang S, Li X, Wang X
Biochemical and biophysical research communications 2025 Nov 1;787:152788
Biochemical and biophysical research communications 2025 Nov 1;787:152788
Formoterol, a clinically approved drug, inhibits ferroptosis by suppressing lipid peroxidation and attenuates APAP-induced acute liver injury.
Teng LS, Ying ZD, Sun XH, Hou HC, Qiu SD, Liu P, Li KJ, Zhang L, Sheng XH
Chemico-biological interactions 2025 Nov 1;421:111724
Chemico-biological interactions 2025 Nov 1;421:111724
Identification and Validation of Potential Immune-Related Genes for Endometriosis.
Zhang Y, Wu L, Yuan W, Ren Z, Tang L, Kuang J, Li L, Liang Y
American journal of reproductive immunology (New York, N.Y. : 1989) 2025 May;93(5):e70091
American journal of reproductive immunology (New York, N.Y. : 1989) 2025 May;93(5):e70091
FOXO3a-BAP1 axis regulates neuronal ferroptosis in early brain injury after subarachnoid hemorrhage.
Liu C, Tian Q, Li Z, Wang G, Han W, Jiang S, Sun Z, Xu Q, Wang L, Liao J, Li M
Redox biology 2025 May;82:103550
Redox biology 2025 May;82:103550
Brigatinib activates inflammasomes: Implication for immune-related adverse events.
Noda T, Tanaka S, Maruta Y, Haruna M, Mizuguchi S, Fujimoto A, Urashima K, Kohda Y, Kato R
Toxicology and applied pharmacology 2025 May;498:117310
Toxicology and applied pharmacology 2025 May;498:117310
Sirt1 overexpression inhibits chondrocyte ferroptosis via Ftl deacetylation to suppress the development of osteoarthritis.
Xiong X, Huang H, Wang N, Zhou K, Song X
Journal of bone and mineral metabolism 2025 May;43(3):203-215
Journal of bone and mineral metabolism 2025 May;43(3):203-215
The ferroptosis of sertoli cells inducing blood-testis barrier damage is produced by oxidative stress in cryptorchidism.
Zeng J, Yuan L, Chen G, Qi Y, Qie X, Jin Y, Chen Y, Li H
Free radical biology & medicine 2025 May;232:97-106
Free radical biology & medicine 2025 May;232:97-106
Adipose stem cells ameliorate erectile dysfunction in diabetes mellitus rats by attenuating ferroptosis through NRP1 with SLC7A11 interaction.
Luo JQ, Wang L, Liao ZQ, Lu BX, Luo CY, He HY, Ou Yang ZH, Duan SB, He SH, Wei AY, Zhang HB
Free radical biology & medicine 2025 May;232:40-55
Free radical biology & medicine 2025 May;232:40-55
Pad2 deletion induces anxiety‑like behaviors and memory deficits in mice.
Lv X, Deng H, Li C, Gao W, Zhang Y, Gao Y, Zhao B, Shi C, Gao J, Liu Z
Brain research bulletin 2025 May;224:111327
Brain research bulletin 2025 May;224:111327
Neuroprotective effects of hirudin against cerebral ischemia-reperfusion injury via inhibition of CCL2-mediated ferroptosis and inflammatory pathways.
Liao J, Chen H, Liao Y, Luo C, Wang Z, Zhang F, Fu C
Brain research bulletin 2025 May;224:111293
Brain research bulletin 2025 May;224:111293
Polyphyllin VII promotes hepatic stellate cell ferroptosis via the HIC1/CX3CL1/GPX4 axis.
Jiang F, Li X, Li M, Zhang W, Li Y, Lin L, He L, Zheng J
Journal of pharmaceutical analysis 2025 May;15(5):101147
Journal of pharmaceutical analysis 2025 May;15(5):101147
Resveratrol Promotes Wound Healing by Enhancing Angiogenesis via Inhibition of Ferroptosis.
Pan Y, Xia M, Luo J, Lu S
Food science & nutrition 2025 May;13(5):e70254
Food science & nutrition 2025 May;13(5):e70254
Human antigen R -mediated autophagy-related gene 3 methylation enhances autophagy-driven ferroptosis in Crohn's disease colitis.
Li Z, Chang Y, He D, Dong K, Zhang H, Wang S
International immunopharmacology 2025 May 8;154:114565
International immunopharmacology 2025 May 8;154:114565
OTULIN orchestrates NCOA4-FTH1 complex to alleviate APAP-induced hepatocyte Ferroptosis.
Gao L, Chang X, Han Y, Li J, Meng Y, Yang X, Jiang Z
International immunopharmacology 2025 May 8;154:114490
International immunopharmacology 2025 May 8;154:114490
Extracellular vesicles derived from bone marrow mesenchymal stem cells regulate SREBF2/HMGB1 axis by transporting miR-378a-3p to inhibit ferroptosis in intestinal ischemia-reperfusion injury.
Liu Z, Zhao Z, Xiao Z, Li M, Wang X, Huang Y, Li Y
Cell death discovery 2025 May 7;11(1):223
Cell death discovery 2025 May 7;11(1):223
Shenfu injection ameliorates hepatic ischemia-reperfusion injury through induction of ferroptosis via JAK2/STAT3 pathway.
Huang P, Yu X, Gao Z, Yang Q, Lin Y, Tu J, Cao Y, Liu Y, Su W, Cao G
Journal of ethnopharmacology 2025 May 28;348:119889
Journal of ethnopharmacology 2025 May 28;348:119889
Inhibition of Cyclooxygenase-2 Upregulates the Nuclear Factor Erythroid 2-related Factor 2 Signaling Pathway to Mitigate Hepatocyte Ferroptosis in Chronic Liver Injury.
Yang Z, Tai Y, Lan T, Zhao C, Gao JH, Tang CW, Tong H
Journal of clinical and translational hepatology 2025 May 28;13(5):409-417
Journal of clinical and translational hepatology 2025 May 28;13(5):409-417
OTUD4 inhibits ferroptosis by stabilizing GPX4 and suppressing autophagic degradation to promote tumor progression.
Chen J, Huang C, Mei J, Lin Q, Chen W, Tang J, Wei X, Mo C, Zhang Y, Zeng Q, Mo X, Tang W, Luo T
Cell reports 2025 May 27;44(5):115681
Cell reports 2025 May 27;44(5):115681
MSC-derived exosomal miR-125b-5p suppressed retinal microvascular endothelial cell ferroptosis in diabetic retinopathy.
Tong J, Chen Y, Ling X, Huang Z, Yao G, Xie Z
Stem cells (Dayton, Ohio) 2025 May 27;43(6)
Stem cells (Dayton, Ohio) 2025 May 27;43(6)
Melatonin inhibits salivary gland epithelial cell ferroptosis via the NRF2/HO-1/GPX4 signaling pathway in primary Sjögren's syndrome.
Weng X, Wang S, Wang Q, Wei M, Cheng B
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2025 May 24;74(1):84
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2025 May 24;74(1):84
Astilbin Alleviates IL-17-Induced Hyperproliferation and Inflammation in HaCaT Cells via Inhibiting Ferroptosis Through the cGAS-STING Pathway.
Xu X, Zhang H, Chang A, Peng H, Li S, Zhang K, Wang W, Yin X, Qu C, Dong X, Ni J
International journal of molecular sciences 2025 May 24;26(11)
International journal of molecular sciences 2025 May 24;26(11)
Homocysteine induces endometrial ferroptosis via MAPK pathway in recurrent pregnancy loss.
Yang X, Wang L, Wang R, Ding N, He Y, Wang F
Placenta 2025 May 23;165:148-161
Placenta 2025 May 23;165:148-161
Arginine Deprivation Induces Quiescence and Confers Vulnerability to Ferroptosis in Colorectal Cancer.
Lin Y, Zhang Y, Huang T, Chen J, Li G, Zhang B, Xu L, Wang K, He H, Chen H, Liu D, Guo S, He X, Lan P
Cancer research 2025 May 2;85(9):1663-1679
Cancer research 2025 May 2;85(9):1663-1679
Study on Cellular Mechanism of Improving Inflammatory Effect of Gastrodin.
Zheng X, Gong T, Yu W, Xu S, Tang C, Zhong Y, Zhu Z
The Tohoku journal of experimental medicine 2025 May 2;265(4):249-259
The Tohoku journal of experimental medicine 2025 May 2;265(4):249-259
NCOA5 induces sorafenib resistance in hepatocellular carcinoma by inhibiting ferroptosis.
Gao S, Fan L, Wang H, Wang A, Hu M, Zhang L, Sun G
Cell death discovery 2025 May 2;11(1):215
Cell death discovery 2025 May 2;11(1):215
Cohabitation facilitates microbiome shifts that promote isoflavone transformation to ameliorate liver injury.
Zeng Y, Wu R, He Y, Zhang Q, Wang Z, Qin P, Yang F, Han Y, Hao M, Zheng Y, Gao L, Chen X, Zhao X, Zeng Z, Lian ZX, Xiao W, Liu Z, Zhao ZB, Gong S
Cell host & microbe 2025 May 14;33(5):688-704.e10
Cell host & microbe 2025 May 14;33(5):688-704.e10
Platelet-Rich Plasma-Derived Exosome-Encapsulated Hydrogels Accelerate Diabetic Wound Healing by Inhibiting Fibroblast Ferroptosis.
Wang S, Wu J, Ren K, Zhang Y, Gao F, Chen Y, Chen C, Lu J
ACS applied materials & interfaces 2025 May 14;17(19):27923-27936
ACS applied materials & interfaces 2025 May 14;17(19):27923-27936
TRIM21 knockdown alleviates hemorrhage induced hepatic ischemia reperfusion injury by suppressing ferroptosis-induced NETs.
Wang S, Li Z, Chang Y, He D, Dong K, Cheng X
Scientific reports 2025 May 14;15(1):16731
Scientific reports 2025 May 14;15(1):16731
TNF-α inhibits Epstein Barr virus reactivation through the GPX4 mediated glutathione pathway.
Zhang Y, Wu Y, Ding B, Li Q, Chen X, Liu H, Xu M, Lan Y, Li Y
Scientific reports 2025 May 12;15(1):16448
Scientific reports 2025 May 12;15(1):16448
The anti-Alzheimer's disease effects of ganoderic acid A by inhibiting ferroptosis-lipid peroxidation via activation of the NRF2/SLC7A11/GPX4 signaling pathway.
Lu Q, Shao N, Fang Z, Ouyang Z, Shen Y, Yang R, Liu H, Cai B, Wei T
Chemico-biological interactions 2025 May 1;412:111459
Chemico-biological interactions 2025 May 1;412:111459
LncRNA TCONS_00067339 as a key regulatory factor inducing decreased cell viability and ferroptosis in neonatal hypoxic-ischemic brain damage.
Li Y, Sun J, Lai C, Li T, Zhang L, Zhang F, Ma S, Sun M, Jiang H
Brain research 2025 May 1;1854:149562
Brain research 2025 May 1;1854:149562
Benzyl butyl phthalate promotes ferroptosis in Sertoli cells via disrupting ceruloplasmin-mediated iron balance.
Dong Y, Shu S, Yu X, Chen X, Li Q, Shen X, Yu Y
Toxicology 2025 Mar;512:154078
Toxicology 2025 Mar;512:154078
Bergapten Ameliorates Renal Fibrosis by Inhibiting Ferroptosis.
Li L, Cai W, Zhang H, Tang J, Yang Y, Huang Y, Xi Q, Zhang R
Phytotherapy research : PTR 2025 Mar;39(3):1355-1371
Phytotherapy research : PTR 2025 Mar;39(3):1355-1371
Integrative bioinformatics analysis reveals CGAS as a ferroptosis-related signature gene in sepsis and screens the potential natural inhibitors of CGAS.
Chen J, Feng M, Zhang T, Zhong M, Wang Y, Zhang Q, Sun Y
International journal of biological macromolecules 2025 Mar;297:139778
International journal of biological macromolecules 2025 Mar;297:139778
Inhibition of ferroptosis protects intrahepatic bile duct cells against ischemia-reperfusion and bile salt toxicity.
Zhou H, Zhou X, Huang G, Zhao Y, Lan P, Chen Z
Biochemical pharmacology 2025 Mar;233:116788
Biochemical pharmacology 2025 Mar;233:116788
Repurposing alcohol-abuse drug disulfiram for the treatment of KSHV-infected primary effusion lymphoma by activating antiviral innate immunity.
Wang L, Liu Z, Xu Z, Wang W, Yang J, Zhang J, He S, Liang Q, Li T
PLoS pathogens 2025 Mar;21(3):e1012957
PLoS pathogens 2025 Mar;21(3):e1012957
Piceatannol upregulates USP14-mediated GPX4 deubiquitination to inhibit neuronal ferroptosis caused by cerebral ischemia-reperfusion in mice.
Zhao Q, Wang X, Zhang T, Guo S, Liu X, Wan S, Guo Y, Zhang Q, Li J, Wang S, Dong L
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Mar;197:115281
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Mar;197:115281
Exosome-Derived CDC42 From Hypoxia-Pretreated Neural Stem Cells Inhibits ACSL4-Related Ferroptosis to Alleviate Vascular Injury in Parkinson's Disease Mice Models.
Li Y, Jiang J, Li J, Liu S, Wang C, Yu Z, Xia Y
Journal of neurochemistry 2025 Mar;169(3):e70027
Journal of neurochemistry 2025 Mar;169(3):e70027
p53 inhibits OTUD5 transcription to promote GPX4 degradation and induce ferroptosis in gastric cancer.
Zhang J, Tian T, Li X, Xu K, Lu Y, Li X, Zhao X, Cui Z, Wang Z, Zhou Y, Xu Y, Li H, Zhang Y, Du Y, Lv L, Xu Y
Clinical and translational medicine 2025 Mar;15(3):e70271
Clinical and translational medicine 2025 Mar;15(3):e70271
HMGB1 secretion by resveratrol in NSCLC: A pathway to ferroptosis-mediated platelet activation suppression.
Zhang Y, Bao S, Zeng J, Liu J, Li X, Zhang B, Wang H, Cheng Y, Zhang H, Xia W, Zu L, Xu X, Xu S, Song Z
Cellular signalling 2025 Mar;127:111607
Cellular signalling 2025 Mar;127:111607
The Lactate-Primed KAT8‒PCK2 Axis Exacerbates Hepatic Ferroptosis During Ischemia/Reperfusion Injury by Reprogramming OXSM-Dependent Mitochondrial Fatty Acid Synthesis.
Yuan J, Yang M, Wu Z, Wu J, Zheng K, Wang J, Zeng Q, Chen M, Lv T, Shi Y, Yang J, Yang J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Mar;12(11):e2414141
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Mar;12(11):e2414141
HPV E6/E7-Induced Acetylation of a Peptide Encoded by a Long Non-Coding RNA Inhibits Ferroptosis to Promote the Malignancy of Cervical Cancer.
Qi X, Zhou J, Wang X, Shen Y, Cao Y, Jiang L, Shen M, Zhang H, Wang T, Wei P, Xu R, Yang Y, Ding X, Wang C, Jia X, Yan Q, Li W, Lu C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Mar;12(10):e2414018
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Mar;12(10):e2414018
AC129507.1 is a ferroptosis-related target identified by a novel mitochondria-related lncRNA signature that is involved in the tumor immune microenvironment in gastric cancer.
Yu S, Liang J, Liu L, Chen M, Chen C, Zhou D
Journal of translational medicine 2025 Mar 6;23(1):290
Journal of translational medicine 2025 Mar 6;23(1):290
Gallic acid alleviates ferroptosis by negatively regulating APOC3 and improves nerve function deficit caused by traumatic brain injury.
Liu Y, Fu X, Li J, Guo J, Zhao Z, Zheng J
Scientific reports 2025 Mar 6;15(1):7815
Scientific reports 2025 Mar 6;15(1):7815
ALPK1 signaling pathway activation by HMGB1 drives microglial pyroptosis and ferroptosis and brain injury after acute ischemic stroke.
Du O, Yan YL, Yang HY, Yang YX, Wu AG, Guo YK, Li K, Qiao G, Du JR, Long FY
International immunopharmacology 2025 Mar 6;149:114229
International immunopharmacology 2025 Mar 6;149:114229
Ovarian aging-associated downregulation of GPX4 expression regulates ovarian follicular development by affecting granulosa cell functions and oocyte quality.
Hu J, Wang H, Fang J, Jiang R, Kong Y, Zhang T, Yang G, Jin H, Shi S, Song N, Qi L, Huang X, Wu Z, Yao G
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Mar 31;39(6):e70469
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Mar 31;39(6):e70469
Edaravone dextranol alleviates ferroptosis, Cuproptosis, and blood-brain barrier damage after acute cerebral infarction.
Jin G, Han W, Duan T, Xue Z, Song C, Xu Y, Yu M
Metabolic brain disease 2025 Mar 3;40(3):134
Metabolic brain disease 2025 Mar 3;40(3):134
Phenolics and Phenolic Glycosides from Wrightia pubescens and Their Hepatoprotective Activities.
Chen X, Yi P, Lv H, Zhang M, Yang J, Zhang Z, Zhao Z, Mu Y, Han L, Huang X
Journal of natural products 2025 Mar 28;88(3):631-643
Journal of natural products 2025 Mar 28;88(3):631-643
Gancao Xiexin decoction attenuated experimental colitis through suppressing ACSL4-mediated ferroptosis.
Pan Z, Gan C, Zhi S, Yang Y, Zhang Y, Li L, Zhang S, Huang Q
Journal of ethnopharmacology 2025 Mar 26;344:119532
Journal of ethnopharmacology 2025 Mar 26;344:119532
USP5 Suppresses Ferroptosis in Bladder Cancer Through Stabilization of GPX4.
Liu C, Deng Y, Huang L, Nie X, Jiang Y, Zhang X, Zhang H
Current issues in molecular biology 2025 Mar 20;47(3)
Current issues in molecular biology 2025 Mar 20;47(3)
Increased melanin induces aberrant keratinocyte - melanocyte - basal - fibroblast cell communication and fibrogenesis by inducing iron overload and ferroptosis resistance in keloids.
Shi X, Xia X, Xiao Y, Zhang Y, Gong Y, Chen Y, Shi C, Wang W, Liu J, Huang J, Liu M, Xu Z, Ma Y, Shi M, Wang J, Wu W
Cell communication and signaling : CCS 2025 Mar 18;23(1):141
Cell communication and signaling : CCS 2025 Mar 18;23(1):141
Nrf2 ameliorates defective autophagic processes and thereby inhibits ferroptosis in acute pancreatitis by suppressing Beclin1-Slc7a11 complex formation.
Li J, Jia YC, Zhang H, Wang Z, Ding Y, Cao F, Wang G, Li F
Free radical biology & medicine 2025 Mar 16;230:294-308
Free radical biology & medicine 2025 Mar 16;230:294-308
Modulating HIF-1α/HIF-2α homeostasis with Shen-Qi-Huo-Xue formula alleviates tubular ferroptosis and epithelial-mesenchymal transition in diabetic kidney disease.
Yang R, Liu W, Zhou Y, Cheng B, Liu S, Wu R, Liu Y, Li J
Journal of ethnopharmacology 2025 Mar 13;343:119478
Journal of ethnopharmacology 2025 Mar 13;343:119478
Vagus nerve stimulation alleviates myocardial injury following hepatic ischemia-reperfusion in rats by inhibiting ferroptosis via the activation of the SLC7A11/GPX4 axis.
Zhang P, Qin Y, Wang H, Wang J
European journal of medical research 2025 Mar 12;30(1):162
European journal of medical research 2025 Mar 12;30(1):162
Bisphenol F induces spermatogenic cell ferroptosis via FTO-mediated m6A regulation of FTH1.
Zhou SM, Shi Y, Li JY, Wang N, Zeng Y, Chen HQ, Tan YP, Deng SW, Liu QQ, Huang XQ, Wang YQ, Zhou ZY, Liu WB
Free radical biology & medicine 2025 Mar 1;229:364-373
Free radical biology & medicine 2025 Mar 1;229:364-373
Disorders of Iron Metabolism: A "Sharp Edge" of Deoxynivalenol-Induced Hepatotoxicity.
Guan H, Cui Y, Hua Z, Deng Y, Deng H, Deng J
Metabolites 2025 Mar 1;15(3)
Metabolites 2025 Mar 1;15(3)
Exosomal miR-196a-5p Secreted by Bone Marrow Mesenchymal Stem Cells Inhibits Ferroptosis and Promotes Drug Resistance of Acute Myeloid Leukemia.
Fan B, Wang L, Hu T, Zheng L, Wang J
Antioxidants & redox signaling 2025 Jun;42(16-18):933-953
Antioxidants & redox signaling 2025 Jun;42(16-18):933-953
Silibinin alleviates acute liver failure by modulating AKT/GSK3β/Nrf2/GPX4 pathway.
Li Y, Li H, Sun M, Chen H, Xiao Y, Wang J, Zhang Y, Fang S, Kou J
Naunyn-Schmiedeberg's archives of pharmacology 2025 Jun;398(6):7625-7639
Naunyn-Schmiedeberg's archives of pharmacology 2025 Jun;398(6):7625-7639
Quercetin-loaded exosomes delivery system prevents myopia progression by targeting endoplasmic reticulum stress and ferroptosis in scleral fibroblasts.
Zhao L, Dong X, Guo B, Song J, Bi H
Materials today. Bio 2025 Jun;32:101896
Materials today. Bio 2025 Jun;32:101896
Sorafenib-loaded metal-organic framework nanoparticles for anti-hepatocellular carcinoma effects through synergistically potentiating ferroptosis and remodeling tumor immune microenvironment.
Yan Y, Hu J, Han N, Li HT, Yang X, Li LG, Xu Z, Xia F, Li J, Li TF, Chen R
Materials today. Bio 2025 Jun;32:101848
Materials today. Bio 2025 Jun;32:101848
Injectable deferoxamine-loaded microsphere hydrogels for inhibition of ferroptosis and promotion of third-degree burn wound healing.
Chai L, Huang J, Wang M, Huang Y, Huang Z, Zhang R, He L, Wang H, Chen D, Lei Y, Guo L
Materials today. Bio 2025 Jun;32:101806
Materials today. Bio 2025 Jun;32:101806
Enhanced inhibition of neuronal ferroptosis and regulation of microglial polarization with multifunctional traditional Chinese medicine active ingredients-based selenium nanoparticles for treating spinal cord injury.
Mai L, Liu J, Wu H, Wang H, Lin Z, Rao S, Sun W, Tan A, Lin Y, Chen B
Materials today. Bio 2025 Jun;32:101758
Materials today. Bio 2025 Jun;32:101758
Novel pH-responsive lipid nanoparticles deliver UA-mediated mitophagy and ferroptosis for osteoarthritis treatment.
Yi G, Li M, Zhou J, Li J, Song X, Li S, Liu J, Zhang H, Chen Z
Materials today. Bio 2025 Jun;32:101697
Materials today. Bio 2025 Jun;32:101697
Bufotalin loaded biomimetic nanodrug for combined chemo/photodynamic therapy of cancer.
Chen S, Fan J, Xie Q, Qin Y, Xie H, Xiao C, Wang W, Liu B
Materials today. Bio 2025 Jun;32:101684
Materials today. Bio 2025 Jun;32:101684
Optically controllable nanoregulators enable tumor-specific pro-ferroptosis lipometabolic reprogramming for in-situ adjuvant-free vaccination.
Li M, Li Y, Yao X, Liu Y, Cai K, Yang H, Luo Z
Biomaterials 2025 Jun;317:123096
Biomaterials 2025 Jun;317:123096
Nutrient deficiency-induced downregulation of SNX1 inhibits ferroptosis through PPARs-ACSL1/4 axis in colorectal cancer.
Qian LH, Wen KL, Guo Y, Liao YN, Li MY, Li ZQ, Li SX, Nie HZ
Apoptosis : an international journal on programmed cell death 2025 Jun;30(5-6):1391-1409
Apoptosis : an international journal on programmed cell death 2025 Jun;30(5-6):1391-1409
Antitumor/anti-inflammatory effects/tissue healing as an all-in-one therapeutic strategy for nasopharyngeal carcinoma.
Ni F, Lv H, Lin L, Zhang Y, Qiao Y, Zhang X, Li Z, Wang X, Dai X, Dong J
Journal of nanobiotechnology 2025 Jun 9;23(1):431
Journal of nanobiotechnology 2025 Jun 9;23(1):431
Mechanistic evaluation of a traditional herbal decoction in attenuating hepatic fibrosis via Nrf2/GPX4 pathway activation and ferroptosis inhibition.
Liu JJ, Zhou XQ, Zhou JL, Tong LJ, Hu LX, Liu X, Hu LM, Zhou CX, Dai Q
Hereditas 2025 Jun 9;162(1):100
Hereditas 2025 Jun 9;162(1):100
α9 Nicotinic Acetylcholine Receptor Promotes Tumor Proliferation and Suppresses Ferroptosis in Triple-Negative Breast Cancer.
Feng X, Tian Y, Guo X, Lei JH, Yu J, Zheng C, Chen M, Ding RB, Kwok HF, Luo S, Bao J
Biomolecules 2025 Jun 8;15(6)
Biomolecules 2025 Jun 8;15(6)
Oligo-peptide I-C-F-6 mitigates polymicrobial sepsis-induced cardiac dysfunction in mice.
Li H, Li G, Gao Y, Ma Y, Yu Z, Zhang A, Yang G, Hou Z, Zhang Y, Yu Y, Zhang Z
European journal of pharmacology 2025 Jun 5;996:177545
European journal of pharmacology 2025 Jun 5;996:177545
Sirtuin-3 activation by honokiol attenuated anesthesia/surgery-induced cognitive impairment and neuronal ferroptosis via inhibiting mitochondrial GPX4 acetylation.
Zeng L, Hu P, Wang X, Ding X, Wang Q, Luo L, Zhang Y, Li M, Zhao Y, Li S, Luo A
Journal of nanobiotechnology 2025 Jun 4;23(1):414
Journal of nanobiotechnology 2025 Jun 4;23(1):414
African swine fever virus A151R downregulates cGAS-STING-mediated IFN-β production by promoting lipid peroxidation through ferritinophagy-induced ferroptosis.
Chen Y, Wang J, Zhou Y, Liu M, Li W, Deng Y, Yang Y, Fang C, Niu S, Dai J, Dai H
Cellular and molecular life sciences : CMLS 2025 Jun 28;82(1):263
Cellular and molecular life sciences : CMLS 2025 Jun 28;82(1):263
Mitochondrial alanyl-tRNA synthetase 2 mediates histone lactylation to promote ferroptosis in intestinal ischemia-reperfusion injury.
Dong W, Huang SX, Qin ML, Pan Z
World journal of gastrointestinal surgery 2025 Jun 27;17(6):106777
World journal of gastrointestinal surgery 2025 Jun 27;17(6):106777
Marsdenia tenacissima extract accelerates ferroptosis of osteosarcoma cells by upregulating HO-1 and activating mitophagy.
Xiang D, Zhang X, Xue X, Liang H, Meng J, Zhao S, Yang J, Zhou Y, Hu Y, Xu L, Shi M, Zhang J, Wang M, Chen J, Han Y
Journal of ethnopharmacology 2025 Jun 26;350:120055
Journal of ethnopharmacology 2025 Jun 26;350:120055
Network pharmacology analysis reveals that coumestrol targets ZYX to inhibit ferroptosis and alleviate acute pancreatitis.
Chen J, Xu H, Gao L, Niu L, Huang Z, Liu S, Huang S, Chen Y, Li J, Tan P, Fu W
International immunopharmacology 2025 Jun 26;159:114948
International immunopharmacology 2025 Jun 26;159:114948
CISD2 ameliorates heatstroke-associated early cognitive deficits by inhibiting ferroptosis and maintaining dendritic spine density in hippocampal neurons in mice.
Zeng L, Sun J, Ji K, Zhang L, Niu J, Ma K, Yan Y, Hei Z, Sun Y
Neuroscience 2025 Jun 21;577:282-299
Neuroscience 2025 Jun 21;577:282-299
Salidroside Exerts Neuroprotective Effects via Inhibiting Ferroptosis in Mice with Traumatic Brain Injury.
Huang Y, He Y, Zhao X, Zou Y, Ding W, Wei L
Neurochemical research 2025 Jun 21;50(4):204
Neurochemical research 2025 Jun 21;50(4):204
Roles of ACSL4/GPX4 and FSP1 in oxalate-induced acute kidney injury.
Ye K, Lan R, Chen Z, Lai K, Song Y, Li G, Ma H, Chen H, Xu Y
Cell death discovery 2025 Jun 17;11(1):279
Cell death discovery 2025 Jun 17;11(1):279
Targeting SIX2 as a novel sensitization strategy of sorafenib treatment on advanced hepatocellular carcinoma through modulating METTL9-SLC7A11 axis.
Lu J, Cai D, Qian L, Wang Y, Ai S, Song P, Sun F, Sun Y, Liang M, Jiang H, Wang X, Wang M, Lu X, Guan W, Shen X
NPJ precision oncology 2025 Jun 16;9(1):186
NPJ precision oncology 2025 Jun 16;9(1):186
Dingzhen pills inhibit neuronal ferroptosis and neuroinflammation by inhibiting the cGAS-STING pathway for Parkinson's disease mice.
Fu G, Li T, Zhao Y, Zhang S, Xue X, Yang Y, Li T, Luo S, Yue G, Lei T
Chinese medicine 2025 Jun 16;20(1):87
Chinese medicine 2025 Jun 16;20(1):87
Protein Kinase D Knockdown Alleviates Vascular Calcification Through P53-SLC7A11 Axis-Mediated Ferroptosis.
He W, Meng Y, Liu W, Geng J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jun 15;39(11):e70706
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jun 15;39(11):e70706
Genome-guided discovery of coublibactins from Nocardia coubleae and their gallium complexes with potent antileukemic activity.
Tao Q, Cai T, Xiao Y, Han T, Shen L, Cheng C, Xu S, Li A, Zhang P, Chen J, Zhang Y, Tong Q, Cai X
Bioorganic chemistry 2025 Jun 15;160:108508
Bioorganic chemistry 2025 Jun 15;160:108508
Integrating network analysis and experimental validation to reveal the ferroptosis-associated mechanism of velvet antler in the treatment of chronic atrophic gastritis.
Liao Q, Guo Z, Ding C, Zuo R, Liu G
Journal of food and drug analysis 2025 Jun 13;33(2):119-131
Journal of food and drug analysis 2025 Jun 13;33(2):119-131
Polyoxometalate-Containing Nanocomposite Hydrogels for Cascade-Catalytic and Photothermal Dually Enhanced Chemodynamic Therapy.
Cao F, Shao W, Liu Y, Lei W, Pang S, Zhou S, Xu K, Zhong W
ACS applied materials & interfaces 2025 Jun 11;17(23):33633-33647
ACS applied materials & interfaces 2025 Jun 11;17(23):33633-33647
A Dual-Factor Scaffold for Spinal Cord Injury Repair Targeting Inflammation and Ferroptosis.
Zou X, Zhu Y, Shu H, Su X, Xiong J, Ye W, Tang P, Wang H, Gao Y, Song T, Zou Z, Cai W
ACS applied materials & interfaces 2025 Jun 11;17(23):33540-33554
ACS applied materials & interfaces 2025 Jun 11;17(23):33540-33554
BTN3A2 interacted with MFGE8 to alleviate preeclampsia by promoting ferroptosis and inhibiting angiogenesis.
Yuan X, Wang Q, Hu C, Yong W, Li P
Life sciences 2025 Jun 1;370:123584
Life sciences 2025 Jun 1;370:123584
Ambient fine particulate matter induces cardiac fibrosis through triggering ferroptosis by heme degradation induced-iron overload.
Jiang J, Li Y, Chen Y, Wu Q, Ding S
Ecotoxicology and environmental safety 2025 Jun 1;297:118227
Ecotoxicology and environmental safety 2025 Jun 1;297:118227
Brassinin from Brassica campestris L. inhibits colorectal cancer by inducing p62/NRF2/GPX4-regulated ferroptosis.
Wen SY, Gao RR, Chen YY, Wang YJ, Wang XT, Liu HX
Animal models and experimental medicine 2025 Jul;8(7):1155-1165
Animal models and experimental medicine 2025 Jul;8(7):1155-1165
Platelet-rich plasma inhibits ferroptosis and inflammation to alleviate frozen shoulder via activating the CST1/GPX4 signaling pathway.
Ren Z, Hu Z, Zhou Y, Cai G, Xiang S, Ao Z, Hu W, Li X, Wei L
Archives of biochemistry and biophysics 2025 Jul;769:110429
Archives of biochemistry and biophysics 2025 Jul;769:110429
Taurine Attenuates Neuronal Ferroptosis by CSF-Derived Exosomes of GABABR Encephalitis Through GABABR/NF2/P-YAP Pathway.
Zhang C, Zhou T, Qiao S, Lu L, Zhu M, Wang A, Zhang S
Molecular neurobiology 2025 Jul;62(7):9052-9073
Molecular neurobiology 2025 Jul;62(7):9052-9073
Carfilzomib promotes Iodine-125 seed radiation-induced apoptosis, paraptosis, and ferroptosis in esophageal squamous cell carcinoma by aggravating endoplasmic reticulum stress.
Wang C, Zha YL, Wang H, Sun B, Qiang WG, Yuan Y, Shi HB, Hu WW
Translational oncology 2025 Jul;57:102393
Translational oncology 2025 Jul;57:102393
Lung microbiota metabolite L-malic acid attenuates the airway inflammation in asthma by inhibiting ferroptosis.
Lin L, Huang D, Huang H, Xie L, Huang Y, Ye C, Chu L, Qiao Y, Meng X, Cai S, Dong H
Toxicology and applied pharmacology 2025 Jul;500:117396
Toxicology and applied pharmacology 2025 Jul;500:117396
Identification of FADS2 as a Contributor of Ferroptosis Escape in Bladder Cancer.
Li P, Yao S, Qi W, Liu H, Zhang X, Zhou B, Zhang S, Zhang Y, Liang H, Huang H, Zhao Y, Shi B, Chen J, Liu J
Journal of cellular and molecular medicine 2025 Jul;29(14):e70710
Journal of cellular and molecular medicine 2025 Jul;29(14):e70710
Constitutive Hepatic mTORC1 Activation Aggravates Alcohol-Induced Liver Injury via Endoplasmic Reticulum Stress-Mediated Ferroptosis.
Xu L, Zhao Y, Yang Y, Qi E, Liu B, Zhuang P, Song S, Chang T, Chen Z, Kang X, Xiong X
The American journal of pathology 2025 Jul;195(7):1209-1222
The American journal of pathology 2025 Jul;195(7):1209-1222
Identification of a new micropeptide altKLF4 derived from KLF4 that influences myeloma chemotherapeutic sensitivity.
Yao R, Zeng Y, Zhang Y, Cao X, Mao J, Li W, Xu K, Liu L
Cellular signalling 2025 Jul;131:111767
Cellular signalling 2025 Jul;131:111767
p38γ modulates ferroptosis in brain injury caused by ethanol and cerebral ischemia/reperfusion by regulating the p53/SLC7A11 signaling pathway.
Zhu X, Zhao Z, Zhang Y, Li H, Zhou X, Zhu Y, Chen Q, Kan S, Zhou L, Zhao G
Cellular signalling 2025 Jul;131:111728
Cellular signalling 2025 Jul;131:111728
PP1A Modulates the Efficacy of Lenvatinib Plus ICIs Therapy by Inhibiting Ferroptosis in Hepatocellular Carcinoma.
Zhou J, Gao M, Zhang S, Guo WW, He W, Zhang M, Chen X, Dongzhi C, Li X, Yuan Y, Ma W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jul;12(27):e2501730
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jul;12(27):e2501730
Dermal papilla cells-conditioned medium attenuates oxidative stress-induced senescence via ferroptosis inhibition.
Ru Z, Wu Y, Qu Q, Miao Y, Zhu L, Hu Z
Scientific reports 2025 Jul 9;15(1):24789
Scientific reports 2025 Jul 9;15(1):24789
Quercetin nanoformulation-embedded hydrogel inhibits osteopontin mediated ferroptosis for intervertebral disc degeneration alleviation.
Li J, Ren L, Wan L, Liu M, Zhao M, Lin Y, Zheng J, Tang Y, Luo Y, Ma Y, Wang L, Cao P, Chen Z, Ren W, Wang F
Journal of nanobiotechnology 2025 Jul 8;23(1):492
Journal of nanobiotechnology 2025 Jul 8;23(1):492
Design, synthesis, and biological evaluation of quinolinyl-ureido-phenyl-hydrazide derivatives and quinolinyl-hydrazide derivatives as anticancer agents targeting Nur77-mediated ferroptosis.
Gao YF, Yang YJ, Qin JB, Yu MY, Hu SW, Zhang HF, Lin FH, Hu HY, Fang MJ, Zeng JZ
European journal of medicinal chemistry 2025 Jul 5;291:117559
European journal of medicinal chemistry 2025 Jul 5;291:117559
Nuclear receptor FXR inhibits ferroptosis to alleviate hepatic ischemia-reperfusion injury by targeting GPX4 in a mouse model.
Chen M, Guo S, Huang X, Mo Q, Chen Q, Zhang S, Zhang Y, Liu C
Journal of molecular histology 2025 Jul 31;56(4):243
Journal of molecular histology 2025 Jul 31;56(4):243
NEFA Induces Ferroptosis in Transition Dairy Cattle Liver by Increasing Lipid Reactive Oxygen Species and Downregulating SLC7A11.
Zhu Y, Wang G, Feng D, Li S, Zhang X, Yao J, Deng L, Lei X
Journal of agricultural and food chemistry 2025 Jul 30;73(30):18733-18745
Journal of agricultural and food chemistry 2025 Jul 30;73(30):18733-18745
Transcription factor TCF3 promotes bladder cancer development via TMBIM6-Ca(2+)-dependent ferroptosis.
Yang WF, Guo WM, Luo QT, Lu J, Tan ZK, Ye YC, Fan G
Cell death discovery 2025 Jul 3;11(1):303
Cell death discovery 2025 Jul 3;11(1):303
Soy Isoflavone Supplementation in Sow Diet Enhances Antioxidant Status and Promotes Intestinal Health of Newborn Piglets.
Liu L, Niu L, Xu M, Yu Q, Chen L, Deng H, Chen W, Che L
Animals : an open access journal from MDPI 2025 Jul 28;15(15)
Animals : an open access journal from MDPI 2025 Jul 28;15(15)
Cadmium Inhibits Proliferation of Human Bronchial Epithelial BEAS-2B Cells Through Inducing Ferroptosis via Targeted Regulation of the Nrf2/SLC7A11/GPX4 Pathway.
Li H, Qiu Z, Chen L, Zhang T, Wei D, Chen X, Wang Y
International journal of molecular sciences 2025 Jul 25;26(15)
International journal of molecular sciences 2025 Jul 25;26(15)
Large-scale RNA-Seq mining reveals ciclopirox olamine induces TDP-43 cryptic exons.
Sinha IR, Sandal PS, Spence H, Burns GD, Mallika AP, Abbasinejad F, Irwin KE, Cruz ALF, Wang V, Marx SR, Rodríguez JL, Langmead B, Gregory JM, Wong PC, Ling JP
Nature communications 2025 Jul 25;16(1):6878
Nature communications 2025 Jul 25;16(1):6878
Ponicidin triggered ferroptosis in esophageal squamous cell carcinoma by suppressing the SLC7A11/Glutathione/GPX4 signalling axis.
Liu W, Zhang J, Wu M, Ren D, Chen C, Du Z, Li Q, Chang J, Pu Q, Liu Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156925
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156925
Protocatechuic acid suppresses ferroptosis to protect against hypoxic-ischemic encephalopathy by targeting the HIF-1α/VEGFA axis.
Zhang X, Luo J, Bharati L, Hua Z, Chen S, Dong Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156900
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156900
Caffeic acid phenethyl ester protects renal tubular epithelial cells against ferroptosis in diabetic kidney disease via restoring PINK1-mediated mitophagy.
Lu Y, Zhu Y, Feng S, Cong Q, Chen S, Zeng Y, Song K, Hu J
Molecular medicine (Cambridge, Mass.) 2025 Jul 24;31(1):264
Molecular medicine (Cambridge, Mass.) 2025 Jul 24;31(1):264
Gut microbiota-bile acid crosstalk contributes to calcium oxalate nephropathy through Hsp90α-mediated ferroptosis.
Liu L, Ma Y, Jian Z, Liao B, Li Y, Lin L, Wang M, Chen J, Wei J, Yang M, Liu Y, Yuan Y, Wen J, Xiang L, Qi S, Jin X, Wang K
Cell reports 2025 Jul 22;44(7):115936
Cell reports 2025 Jul 22;44(7):115936
Large-sized polystyrene microplastics induce oxidative stress in AML12 cells.
Zhao B, Liu R, Guo S, Li S, Huang Z, Wang Y, Yu C, Hou Z, Zhang Y, Zhang Y, Liu X
Scientific reports 2025 Jul 22;15(1):26616
Scientific reports 2025 Jul 22;15(1):26616
Low doses of ozone alleviate cardiomyocyte ferroptosis induced by hypoxia-reoxygenation injury via the AMPK-mTOR pathway.
Ding Y, Hong T
European journal of medical research 2025 Jul 2;30(1):558
European journal of medical research 2025 Jul 2;30(1):558
The SDF-1α/MTDH axis inhibits ferroptosis and promotes the formation of anti-VEGF-resistant choroidal neovascularization by facilitating the nuclear translocation of SREBP1.
Zou R, Zhang X, Dai X, Yuan Y, Dai J, Yuan F
Cell biology and toxicology 2025 Jul 17;41(1):118
Cell biology and toxicology 2025 Jul 17;41(1):118
S-COS-Se mitigates cadmium-induced oxidative stress, inflammation, and immunotoxicity by restoring immune balance and inhibiting mitochondria-pyroptosis crosstalk.
Zheng H, Dong W, Qiu H, Gao S, Hou L, Dong J, Zhao P, Chen F
Ecotoxicology and environmental safety 2025 Jul 15;300:118462
Ecotoxicology and environmental safety 2025 Jul 15;300:118462
Integrative proteomics and metabolomics analyses reveals the regulation of autophagy and ferroptosis by RAB10 through Slc37a2/mTOR pathway in breast cancer.
Ji Y, Li R, Tang G, Xiao Y, Ye R, Shi J, Geng C, Ran R, Zhu C, Wang W, Chen C, Yang Q
Cellular and molecular life sciences : CMLS 2025 Jul 14;82(1):275
Cellular and molecular life sciences : CMLS 2025 Jul 14;82(1):275
Effects of solamargine in hepatic metastasis of colorectal cancer: induction of ferroptosis and elimination of cancer stem cells.
Liu S, Wu J, Huang H, Hu B, Xie D, Cao F, Li J, Guo C, Peng W, Jin Y, Dai W
Chinese medicine 2025 Jul 11;20(1):110
Chinese medicine 2025 Jul 11;20(1):110
Microglial exosome TREM2 ameliorates ferroptosis and neuroinflammation in alzheimer's disease by activating the Wnt/β-catenin signaling.
Zhu L, Zhou T, Wu L, Zhu X, Chen L, Zhang M, Zhou J, Wang F
Scientific reports 2025 Jul 10;15(1):24968
Scientific reports 2025 Jul 10;15(1):24968
Taurine Attenuates Disuse Muscle Atrophy Through Modulation of the xCT-GSH-GPX4 and AMPK-ACC-ACSL4 Pathways.
Liu X, Chen Y, Zhang L, Qi Z, Yang L, Huang C, Wang L, Lin D
Antioxidants (Basel, Switzerland) 2025 Jul 10;14(7)
Antioxidants (Basel, Switzerland) 2025 Jul 10;14(7)
SETD1B promotes brain cell ferroptosis in ischemic stroke mice via increasing H3K4me3 enrichment on the Tfrc promoter.
Wang L, Liu HR, Liu HQ, Li XS, Tang TT, Wang KJ, Wei GR, Tian J, Zhang YY, Luo XJ
Life sciences 2025 Jul 1;372:123625
Life sciences 2025 Jul 1;372:123625
Translational medicine research on the role of key gene network modulation mediated by procyanidin B2 in the precise diagnosis and treatment of multiple sclerosis.
Liu J, Pu M, Guo D, Xiao Y, Yin JZ, Ma D, Ma CG, Wang Q
Journal of translational medicine 2025 Jul 1;23(1):721
Journal of translational medicine 2025 Jul 1;23(1):721
A Self-Assembling Chimeric Peptide Gear-Set with "Three-in-One" Function for Precision Photodynamic Therapy.
Jiao Q, Zhang T, Zhou S, Luo X, Pei S, Zheng Y, Xu K, Zhong W
Acta biomaterialia 2025 Jul 1;201:559-573
Acta biomaterialia 2025 Jul 1;201:559-573
MiR-125b-5p ameliorates ventilator-induced lung injury in rats by suppressing ferroptosis via the regulation of the Keap1/Nrf2/GPX4 signaling pathway.
Zhang J, He S, Wu K, Wei Y, Li C, Zhu Q, Lian S, Wang L, Wan F, Peng F, Zhang J, Chen Z, Zhang X
Scientific reports 2025 Jul 1;15(1):21199
Scientific reports 2025 Jul 1;15(1):21199
cDTL contributes to breast cancer progression through regulating redox homeostasis via affecting the function of system xc().
Wang S, Liu L, Li X, Li Q, Wang Y, Feng X
Biochemical and biophysical research communications 2025 Jan;744:151196
Biochemical and biophysical research communications 2025 Jan;744:151196
Dehydrocostus lactone suppresses gastric cancer progression by targeting ACLY to inhibit fatty acid synthesis and autophagic flux.
Chen Y, Shen J, Yuan M, Li H, Li Y, Zheng S, Han B, Zhang C, Liu S, Sun Q, Wu J
Journal of advanced research 2025 Jan;67:331-348
Journal of advanced research 2025 Jan;67:331-348
Biomimetic Nanomotors for Deep Ischemia Penetration and Ferroptosis Inhibition in Neuroprotective Therapy of Ischemic Stroke.
Wang R, Nie W, Yan X, Luo K, Zhang Q, Wang T, Lu E, Chen Y, Luo Y, Zhang Z, Wang H, Zhao J, Sha X
Advanced materials (Deerfield Beach, Fla.) 2025 Jan;37(3):e2409176
Advanced materials (Deerfield Beach, Fla.) 2025 Jan;37(3):e2409176
Amelioration of arsenic-induced hepatic injury via sulfated glycosaminoglycan from swim bladder: Modulation of Nrf2 pathway and amino acid metabolism.
Ou J, Liu X, Chen J, Huang H, Wang Z, Xu B, Zhong S
International journal of biological macromolecules 2025 Jan;287:138528
International journal of biological macromolecules 2025 Jan;287:138528
Leonurine restrains granulosa cell ferroptosis through SLC7A11/GPX4 axis to promote the treatment of polycystic ovary syndrome.
Huang X, Geng H, Liang C, Xiong X, Du X, Zhuan Q, Liu Z, Meng L, Zhou D, Zhang L, Fu X, Qi X, Hou Y
Free radical biology & medicine 2025 Jan;226:330-347
Free radical biology & medicine 2025 Jan;226:330-347
Ginsenoside Rb1 targets to HO-1 to improve sepsis by inhibiting ferroptosis.
He S, Ye H, Wang Q, He Y, Liu X, Song J, Zhao C, Hu Y, Luo L, Guo Y, Liu Q
Free radical biology & medicine 2025 Jan;226:13-28
Free radical biology & medicine 2025 Jan;226:13-28
Lipoxin A4 suppresses neutrophil extracellular traps formation through the FPR2-dependent regulation of METTL3 in ischemic stroke.
Wei N, Lu T, Gu J, Cai H
Brain research bulletin 2025 Jan;220:111178
Brain research bulletin 2025 Jan;220:111178
Disruption of Ferroptosis Inhibition and Immune Evasion with Tumor-Activatable Prodrug for Boosted Photodynamic/Chemotherapy Eradication of Drug-Resistant Tumors.
Bi T, Zhao Q, Wang T, Huang R, Liu B, Liu X, Wang Y, Sun Q, Yang Y, Liu Z
Advanced healthcare materials 2025 Jan;14(2):e2403473
Advanced healthcare materials 2025 Jan;14(2):e2403473
Quercetin inhibits hydrogen peroxide-induced cleavage of heat shock protein 90 to prevent glutathione peroxidase 4 degradation via chaperone-mediated autophagy.
Peng C, Li H, Mao Q, Tang K, Sun M, Ai Q, Yang Y, Liu F
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156286
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156286
Bardoxolone methyl triggers Ferroptosis in cardiomyocytes.
Li H, Hong M, Liu Y, Rahman SU, Li X, Zheng F
Human & experimental toxicology 2025 Jan-Dec;44:9603271251394706
Human & experimental toxicology 2025 Jan-Dec;44:9603271251394706
Precise Carrier-Free Pt(IV)-Nanobombs for Apoptosis/Ferroptosis Synergistic Tumor Therapy: A New Effective Method to Obtain Good Chemotherapy and Low Toxicity.
Guo X, Liang XJ, Liu JL, Li ZH, You Z, Zhao D, Song Y, Li L, Song XQ
Journal of medicinal chemistry 2025 Jan 9;68(1):387-404
Journal of medicinal chemistry 2025 Jan 9;68(1):387-404
Melanin-Deferoxamine Nanoparticles Targeting Ferroptosis Mitigate Acute Kidney Injury via RONS Scavenging and Iron Ion Chelation.
Sun J, Shen H, Dong J, Zhang J, Yue T, Zhang R
ACS applied materials & interfaces 2025 Jan 8;17(1):282-296
ACS applied materials & interfaces 2025 Jan 8;17(1):282-296
Deciphering the role of the MALT1-RC3H1 axis in regulating GPX4 protein stability.
Wang J, Liao L, Miao B, Yang B, Li B, Ma X, Fitz A, Wu S, He J, Zhang Q, Ji S, Jin G, Zhang J, Cao Y, Wang H, Qin W, Sun C, Bernards R, Wang C
Proceedings of the National Academy of Sciences of the United States of America 2025 Jan 7;122(1):e2419625121
Proceedings of the National Academy of Sciences of the United States of America 2025 Jan 7;122(1):e2419625121
Gegen Qinlian Decoction inhibits liver ferroptosis in type 2 diabetes mellitus models by targeting Nrf2.
Zhang X, Ji Z, He Q, Yang D, Wang X, Liu C, Zhang C, Yuan J, Xu N, Chu J
Journal of ethnopharmacology 2025 Jan 31;340:119290
Journal of ethnopharmacology 2025 Jan 31;340:119290
Ethyl acetate fraction of Thesium chinense Turcz. alleviates chronic obstructive pulmonary disease through inhibition of ferroptosis mediated by activating Nrf2/SLC7A11/GPX4 axis.
Liu MJ, Xu ZP, Guan YQ, Wang YY, Wen XS, Li GH, Wang XN, Shen T
Journal of ethnopharmacology 2025 Jan 30;337(Pt 1):118776
Journal of ethnopharmacology 2025 Jan 30;337(Pt 1):118776
The RNA Demethyltransferase FTO Regulates Ferroptosis in Major Depressive Disorder.
Meng K, Liu Z, Yu Y, Zhang E, Yu X, Meng P, Xiu J
International journal of molecular sciences 2025 Jan 26;26(3)
International journal of molecular sciences 2025 Jan 26;26(3)
Isovitexin targets SIRT3 to prevent steroid-induced osteonecrosis of the femoral head by modulating mitophagy-mediated ferroptosis.
Fan Y, Chen Z, Wang H, Jiang M, Lu H, Wei Y, Hu Y, Mo L, Liu Y, Zhou C, He W, Chen Z
Bone research 2025 Jan 26;13(1):18
Bone research 2025 Jan 26;13(1):18
Downregulation of ferroptosis-related ATF3 alleviates lupus nephritis progression.
Xiao G, Tang S, Zhang Y, Yuan Q, Sun D, Wang W
Gene 2025 Jan 20;934:149009
Gene 2025 Jan 20;934:149009
Comprehensive Pan-Cancer Analysis and Functional Studies Reveal SLC2A6 as a Ferroptosis Modulator in Hepatocellular carcinoma.
Yan G, Huang H, Lu Z, Chen M, Wang X, Zhong P, Qin C, Mo S, Han C, Luo X, Ye X
Scientific reports 2025 Jan 20;15(1):2545
Scientific reports 2025 Jan 20;15(1):2545
Melanoma bone metastasis-induced osteocyte ferroptosis via the HIF1α-HMOX1 axis.
Jia Y, Li R, Li Y, Kachler K, Meng X, Gießl A, Qin Y, Zhang F, Liu N, Andreev D, Schett G, Bozec A
Bone research 2025 Jan 16;13(1):9
Bone research 2025 Jan 16;13(1):9
ZC3H13 may participate in the ferroptosis process of sepsis-induced cardiomyopathy by regulating the expression of Pnn and Rbm25.
Lin W, Li H, Chang J, Huang Y
Gene 2025 Jan 15;933:148944
Gene 2025 Jan 15;933:148944
Trehalose Inhibits ferroptosis Through Activating SIRT3/SOD2 Signaling Axis and Alleviates Brain Injury After Traumatic Brain Injury.
Mu Z, Sun Z, Wu S, Yang J, Wang P, Zhao X
Neurochemical research 2025 Jan 11;50(1):78
Neurochemical research 2025 Jan 11;50(1):78
Ghrelin Induces Ferroptosis Resistance and M2 Polarization of Microglia to Alleviate Neuroinflammation and Cognitive Impairment in Alzheimer's Disease.
Guo Y, Zhao J, Liu X, Lu P, Liang F, Wang X, Wu J, Hai Y
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2025 Jan 11;20(1):6
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2025 Jan 11;20(1):6
High Salt Exacerbates Myocardial Dysfunction In Vitro and In Vivo by Promoting SIRT1/Nrf2-Mediated Ferroptosis.
Guanji W, Fuqiang L, Fei Y, Zhang T, Xiaolin C
Clinical and experimental pharmacology & physiology 2025 Feb;52(2):e70016
Clinical and experimental pharmacology & physiology 2025 Feb;52(2):e70016
Chronic environmental exposure to polystyrene microplastics increases the risk of nonalcoholic fatty liver disease.
Shi Y, Hong R, Fan Z, Huan R, Gao Y, Ma M, Liu T, Pan C
Toxicology 2025 Feb;511:154067
Toxicology 2025 Feb;511:154067
Ginkgetin enhances breast cancer radiotherapy sensitization by suppressing NRF2-HO-1 axis activity.
Duan Q, Cui Z, Wang M, Li R, Han F, Ma J
Toxicology and applied pharmacology 2025 Feb;495:117199
Toxicology and applied pharmacology 2025 Feb;495:117199
Artemisinin inhibits neuronal ferroptosis in Alzheimer's disease models by targeting KEAP1.
Deng PX, Silva M, Yang N, Wang Q, Meng X, Ye KQ, Gao HC, Zheng WH
Acta pharmacologica Sinica 2025 Feb;46(2):326-337
Acta pharmacologica Sinica 2025 Feb;46(2):326-337
EFNA4-enhanced deubiquitination of SLC7A11 inhibits ferroptosis in hepatocellular carcinoma.
Zhong X, Zhu Z, Du Y, Long L, Xie Z, Zhang Y, Yao H, Lin J, Chen F
Apoptosis : an international journal on programmed cell death 2025 Feb;30(1-2):349-363
Apoptosis : an international journal on programmed cell death 2025 Feb;30(1-2):349-363
Iron-glucose oxidase nanogel assembly for amplified starvation-ferroptosis anti-tumor therapy.
Mao L, Ma Y, Wen X, Luo Z, Zhu H, Kong J, Liu S, Fan X, Wang J, He C, Wu YL
International journal of biological macromolecules 2025 Feb;289:138804
International journal of biological macromolecules 2025 Feb;289:138804
Betulinic Acid Inhibits Glioma Progression by Inducing Ferroptosis Through the PI3K/Akt and NRF2/HO-1 Pathways.
Huang J, Li Q, Wang H, Zhang S, Zhou X, Huang F, Chen J, Xu L, Kang D
The journal of gene medicine 2025 Feb;27(2):e70011
The journal of gene medicine 2025 Feb;27(2):e70011
Heat exposure promotes sarcopenia via gut microbiota-derived metabolites.
Guo YF, Liu ZY, Zhou M, Kuang WH, Liu Y, Huang Y, Yin P, Xia ZY
Aging cell 2025 Feb;24(2):e14370
Aging cell 2025 Feb;24(2):e14370
Muribaculum intestinale-derived 3-hydroxybutyric acid from Heterophyllin B attenuated pulmonary fibrosis through IDO1-mediated ferroptosis.
Chen C, Wang J, Cheng M, Xie H, Li W, Zhang C
Pharmacological research 2025 Feb;212:107587
Pharmacological research 2025 Feb;212:107587
Lipid peroxidation inhibition by icaritin and its glycosides as a strategy to combat iron overload-induced osteoporosis in zebrafish.
Yan CY, Gu XY, Tan SY, Mei AY, Mao JH, Dai Y, Niu J, Li WX, Kurihara H, Li YF, He RR
Food research international (Ottawa, Ont.) 2025 Feb;203:115900
Food research international (Ottawa, Ont.) 2025 Feb;203:115900
Modulation of the local angiotensin II: Suppression of ferroptosis and radiosensitivity in nasopharyngeal carcinoma via the HIF-1α-HILPDA axis.
Huang X, Lin K, Chen W, Zhang D, Khan M, Ye X, Wang B, Chen C, Tian Y, Yuan Y, Lin J
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2025 Feb;203:110686
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2025 Feb;203:110686
Long non-coding RNA MIR4435-2HG modulates pancreatic cancer stem cells and chemosensitivity to gemcitabine by targeting the miR-1252-5p/STAT1.
Xie B, Wu P, Liu H, Yang X, Huang L
Journal of translational medicine 2025 Feb 7;23(1):165
Journal of translational medicine 2025 Feb 7;23(1):165
Praeruptorin A screened by a ferrous ion probe inhibited DMT1 and ferroptosis to attenuate Doxorubicin-induced cardiomyopathy.
Li D, Chen Y, Zhang B, Heng X, Yin J, Zhao P, Sun N, Shao C
European journal of medicinal chemistry 2025 Feb 5;283:117108
European journal of medicinal chemistry 2025 Feb 5;283:117108
Identification of Isoliensinine as a Ferroptosis Suppressor with Iron-Chelating Activity.
Song Y, Li M, Li Y, Zhang T, Zhang J, Han D, Lian F, Liu X, Fang X
Journal of natural products 2025 Feb 28;88(2):245-254
Journal of natural products 2025 Feb 28;88(2):245-254
Novel Cell Models to Study Myelin and Microglia Interactions.
Santacreu-Vilaseca M, Moreno-Magallon J, Juanes-Casado A, Gil-Sánchez A, González-Mingot C, Torres P, Brieva L
International journal of molecular sciences 2025 Feb 28;26(5)
International journal of molecular sciences 2025 Feb 28;26(5)
Changyanning tablet alleviates Crohn's disease by inhibiting GPX4-mediated ferroptosis.
Huang Y, Ru Q, Ruan H, Zhang J, Wang Y, Wang C, Chen C, Yu D, Luo J, Yang M
Journal of ethnopharmacology 2025 Feb 27;342:119415
Journal of ethnopharmacology 2025 Feb 27;342:119415
The GPR30-Mediated BMP-6/HEP/FPN Signaling Pathway Inhibits Ferroptosis in Bone Marrow Mesenchymal Stem Cells to Alleviate Osteoporosis.
Chen S, Xiao J, Zhou S, Wumiti T, Zhao Z, Zhao R, Pan Y, Wang Q, Ma Y, Wu L, Guo Y
International journal of molecular sciences 2025 Feb 26;26(5)
International journal of molecular sciences 2025 Feb 26;26(5)
Oxygen Nanobubbles Enhance ICG/Fe(III)-Mediated Dual-Modal Therapy To Induce Ferroptosis in Tumor Treatment.
Yang L, Zhang WH, Li Y, An YL, Wu YM, Gu N, Teng GJ
ACS applied materials & interfaces 2025 Feb 26;17(8):11718-11730
ACS applied materials & interfaces 2025 Feb 26;17(8):11718-11730
Targeting the Leukemia Inhibitory Factor/Leukemia Inhibitory Factor Receptor Axis Reduces the Growth of Inflammatory Breast Cancer by Promoting Ferroptosis.
Romo B, Fuentes Z, Randolph L, Mahajan M, Aller EJ, Ebrahimi B, Santhamma B, Pratap UP, Subbarayalu P, Nagandla H, Thomas C, Nair HB, Vadlamudi RK, Viswanadhapalli S
Cancers 2025 Feb 25;17(5)
Cancers 2025 Feb 25;17(5)
Non-invasive in vivo monitoring of PROTAC-mediated protein degradation using an environment-sensitive reporter.
Li T, Zong Q, Dong H, Ullah I, Pan Z, Yuan Y
Nature communications 2025 Feb 22;16(1):1892
Nature communications 2025 Feb 22;16(1):1892
Superoxide dismutase promotes gastric tumorigenesis mediated by Helicobacter pylori and enhances resistance to 5-fluorouracil in gastric cancer.
Fu H, Zhang Y, Duan Y, Zhang X, Yao J, Yang D, Wei Z, Zhu Z, Xu J, Hu Z, You Q, Yan R, Wang W
iScience 2025 Feb 21;28(2):111553
iScience 2025 Feb 21;28(2):111553
GluOC Induced SLC7A11 and SLC38A1 to Activate Redox Processes and Resist Ferroptosis in TNBC.
Xu J, Bai X, Dong K, Du Q, Ma P, Zhang Z, Yang J
Cancers 2025 Feb 21;17(5)
Cancers 2025 Feb 21;17(5)
Human spindle-shaped urine-derived stem cell exosomes alleviate severe fatty liver ischemia-reperfusion injury by inhibiting ferroptosis via GPX4.
Shi S, Zhu C, Shi S, Li X, Muhammad I, Xu Q, Li X, Zhao Z, Liu H, Fu G, Song M, Huang X, Wang F, Cai J
Stem cell research & therapy 2025 Feb 21;16(1):81
Stem cell research & therapy 2025 Feb 21;16(1):81
Metformin Induces Apoptosis and Ferroptosis of Ovarian Cancer Cells Under Energy Stress Conditions.
Wu Y, Zhang Z, Ren M, Chen Y, Zhang J, Li J, Gao F, Bao Y, Huang Y, Yang X, Song Z
Cells 2025 Feb 2;14(3)
Cells 2025 Feb 2;14(3)
Bio-nanocomplexes impair iron homeostasis to induce non-canonical ferroptosis in cancer cells.
Wang X, Zhang T, Wang S, Shi H, Dong H, Huang Y, Lai W, Hu Y, Yue C
Journal of nanobiotechnology 2025 Feb 19;23(1):121
Journal of nanobiotechnology 2025 Feb 19;23(1):121
Ferroptosis and PANoptosis under hypoxia pivoting on the crosstalk between DHODH and GPX4 in corneal epithelium.
Wu MF, Peng X, Zhang MC, Guo H, Xie HT
Free radical biology & medicine 2025 Feb 16;228:173-182
Free radical biology & medicine 2025 Feb 16;228:173-182
IL-27 regulates macrophage ferroptosis by inhibiting the Nrf2/HO1 signaling pathway in sepsis-induced ARDS.
Xiong M, Luo R, Zhang Z, Liu P, Peng Q, Xu F, Guo M
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2025 Feb 13;74(1):39
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2025 Feb 13;74(1):39
Lactate-Fueled Theranostic Nanoplatforms for Enhanced MRI-Guided Ferroptosis Synergistic with Immunotherapy of Hepatocellular Carcinoma.
Chen X, Zhang F, Lu C, Wu R, Yang B, Liao T, Du B, Wu F, Ding J, Fang S, Zhao Z, Chen M, Shu G, Chen W, Ji J
ACS applied materials & interfaces 2025 Feb 12;17(6):9155-9172
ACS applied materials & interfaces 2025 Feb 12;17(6):9155-9172
β-elemene, a sesquiterpene constituent from Curcuma phaeocaulis inhibits the development of endometriosis by inducing ferroptosis via the MAPK and STAT3 signaling pathways.
Fu Z, Liu H, Kuang Y, Yang J, Luo M, Cao L, Zheng W
Journal of ethnopharmacology 2025 Feb 11;341:119344
Journal of ethnopharmacology 2025 Feb 11;341:119344
The extract from Quzhou Aurantii Fructus attenuates cough variant asthma through inhibiting the TRPV1/Ca(2+)/NFAT/TSLP pathway and ferroptosis via TRPV1 mediation in ovalbumin-induced mice.
Tian M, Huang W, Chen J, Liu X, Wang H, Pan X, Wang L, Li Q, Gao L, Ye Y
Journal of ethnopharmacology 2025 Feb 10;338(Pt 1):119038
Journal of ethnopharmacology 2025 Feb 10;338(Pt 1):119038
Coixol-Loaded Hydrogels Promote Osteochondral Defect Repair via Modulation of Ferroptosis and Autophagy in Chondrocytes.
Zhang L, Zheng G, Zhao W, He C, Huang Z
ACS biomaterials science & engineering 2025 Feb 10;11(2):1096-1105
ACS biomaterials science & engineering 2025 Feb 10;11(2):1096-1105
Integrated network pharmacology, bioinformatics, and experiment analysis to decipher the molecular mechanism of Salidroside on Gastric cancer via targeting NCOA4-mediated ferritinophagy.
Fu Y, Huang G, Cai Y, Ren M, Cheng R, Chai Y, Wang Y, An Y, Yan T, Zhu L, Liu X
Chemico-biological interactions 2025 Feb 1;407:111368
Chemico-biological interactions 2025 Feb 1;407:111368
Puerarin reduces susceptibility to ventricular arrhythmias and inhibits ferroptosis via Sirt1/Nrf2 signaling in high-fat-diet rats.
Jiang S, Qiu S, Mu Y, Liu C, Han Y, Jiang J, Wang Y
Free radical biology & medicine 2025 Feb 1;227:472-484
Free radical biology & medicine 2025 Feb 1;227:472-484
Crucial roles of asprosin in cisplatin-induced ferroptosis and acute kidney injury.
Zheng F, Lei JZ, Wang JX, Xu XY, Zhou B, Ge R, Dai M, Dong HK, Wu N, Li YH, Zhu GQ, Zhou YB
Free radical biology & medicine 2025 Feb 1;227:296-311
Free radical biology & medicine 2025 Feb 1;227:296-311
Luteolin Inhibits Ferroptosis of HUVEC by Regulating the Sirt1/Nrf2 Pathway.
Xiang M, Lin X, Chen H
Cell biochemistry and biophysics 2025 Dec;83(4):5127-5140
Cell biochemistry and biophysics 2025 Dec;83(4):5127-5140
A photothermally triggered cascade bioreactor for cuproptosis and ferroptosis-driven cancer immunotherapy.
Xu J, Wang Y, Williams GR, Zheng Y, Zhang Y, Wang T, Du C, Wang Y, Wu YL, Zhu LM
Journal of colloid and interface science 2025 Dec;699(Pt 1):138100
Journal of colloid and interface science 2025 Dec;699(Pt 1):138100
Indirubin regulates M1/M2 polarization and inhibits ferroptosis in dextran sulfate sodium induced colitis and in cultured THP-1 cells.
Huang YX, Zhang JR, Fu SH, Liu Z, Zhong HJ, Zhong QY, Luo YD, Hu YJ, Zhu HP, Wen B, Chen S
Pharmaceutical biology 2025 Dec;63(1):698-715
Pharmaceutical biology 2025 Dec;63(1):698-715
Exosomal miR-494 from Bone Marrow Mesenchymal Stem Cells Attenuates Ferroptosis and Enhances Spinal Cord Injury Repair by Modulating the SIRT1/HO-1 Pathway.
Shi S, Zhang Z, Shi P, Gong C, Zhao Z, Wang T, Zhou Y, Zhang M, Gao J, Qin S, Wang J, Yu X
Molecular neurobiology 2025 Dec;62(12):16575-16591
Molecular neurobiology 2025 Dec;62(12):16575-16591
Propofol in combination with salvianolic acid A protect against lipopolysaccharide-induced cardiac dysfunction and ferroptosis through activating the SIRT1/FoxO1 signaling under diabetic condition.
Han R, Han K, Zhu J, Zhang A, Zhou J, Huang H, Han H, Zhang L, Liu X, Tang J, Yi B, Ma X, Chu Q, Mo G, Shao Y, Xia Z
Annals of medicine 2025 Dec;57(1):2570796
Annals of medicine 2025 Dec;57(1):2570796
Membrane-Associated RING-CH-Type Finger 6 Protects against Hypertension-Induced Cardiac Remodeling by Suppressing Cardiomyocyte Ferroptosis Through the Degradation of ACSL4.
Hao R, Wang X, Liu C, Xue J
Inflammation 2025 Dec;48(6):4475-4491
Inflammation 2025 Dec;48(6):4475-4491
Network pharmacology combined with experiments to explore the molecular mechanism of Jiawei Erzhi pill protects against atherosclerosis by inhibiting ferroptosis.
Guiping MA, Ran C, Junlong LI, Le S, Shiping HU, Yiyi Z, Chuangxiong H
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2025 Dec;45(6):1330-1341
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2025 Dec;45(6):1330-1341
Ozonated olive oil inhibits melanoma proliferation by inducing ferroptosis.
An SJ, Kashiwakura JI, Katsuyama A, Togi S, Kitai Y, Muromoto R, Miura T, Ichikawa S, Matsuda T
Biochemistry and biophysics reports 2025 Dec;44:102267
Biochemistry and biophysics reports 2025 Dec;44:102267
Sodium butyrate enhances sorafenib-induced ferroptosis and immunogenic cell death by modulating IRF2-Oasl2-cGAS pathway in colorectal cancer.
Xiang Y, Zheng J, Zhao X, Zhou L, Yan Q, Ma Y, Zhou Y, Jiang P, Fang Y, Li W, Pan Y, Tao H, Li W, Xiang F, Hua Y, Li Y, Zheng C, Ge W, Li Y, Yan S, Zhu Y, Xu G
Materials today. Bio 2025 Dec;35:102498
Materials today. Bio 2025 Dec;35:102498
A trojan horse selenium-containing polymer for protective co-delivery of Fe(II) and cisplatin to boost chemo-ferroptosis synergy via GSH-triggered ROS storm.
Luo Z, Hu H, Zheng Z, Chen Y, Lin Y, Teng CP, Loh XJ, Ren C, Wu YL, Yang B
Materials today. Bio 2025 Dec;35:102488
Materials today. Bio 2025 Dec;35:102488
The umbilical cord blood exosome MFG-E8 alleviates hypoxic-ischemic encephalopathy brain injury in neonatal rats by restoring autophagy flux and inhibiting ferroptosis through GSK3β/β-catenin signaling.
Zhao M, Wu Y, Huang L, Wang J, Zhang A
Regenerative therapy 2025 Dec;30:321-332
Regenerative therapy 2025 Dec;30:321-332
High-Dose Ascorbic Acid Combined With Dihydroartemisinin Inhibits Lung Adenocarcinoma Malignancy by Inducing Ferroptosis via SLC7A11/GPX4 Pathway.
Li L, Lu F, Shu S, Jiang X, Lu H, Cao K, Chen Z, Gao J, Liu M, Chang L, Li W
Journal of cellular and molecular medicine 2025 Dec;29(24):e70993
Journal of cellular and molecular medicine 2025 Dec;29(24):e70993
Bavachinin exerts anti-tumor effects by activating TLR4/STING axis-dependent PANoptosis and synergistically enhances chemosensitivity in endometrial cancer.
Shu W, Chen G, Zhang J, Dong K, Zhou T, Cheng S, Zhang T, Zhang J, Li H, Yao Y, Yu S, Liu Y, Zhou X, Shen X, Wang H
Biochemical pharmacology 2025 Dec;242(Pt 2):117321
Biochemical pharmacology 2025 Dec;242(Pt 2):117321
Oridonin mitigates bacterial pneumonia by regulating mitochondrial integrity and ferroptosis via targeting KEAP1/NRF2 signaling.
Zhang W, Chen X, Zhang H, Liu X, Chen C, Lv N, Gao Y, Gao L, Shi L
Biochemical pharmacology 2025 Dec;242(Pt 2):117310
Biochemical pharmacology 2025 Dec;242(Pt 2):117310
PFGA12 ameliorates Hypoxic-Ischemic brain injury by directly regulating PRDX1 and inhibiting ferroptosis.
Chen H, Zhao J, Kang Y, Wang S, Qin D, Yu L, Zhao Y, Zhang G, Dong X
Biochemical pharmacology 2025 Dec;242(Pt 2):117307
Biochemical pharmacology 2025 Dec;242(Pt 2):117307
Astaxanthin suppress ferroptosis through the Akt1-FoxO3a signaling pathway to alleviates brain injury after intracerebral hemorrhage.
Zhang J, Hua Q, Gao L, Yang S, Lu M, Cai Q
Journal of pharmacological sciences 2025 Dec;159(4):310-321
Journal of pharmacological sciences 2025 Dec;159(4):310-321
Ethanol extract of Corydalis decumbens exerts neuroprotective effects against cerebral ischemia-reperfusion injury by targeting ALOX15 to suppress ferroptosis.
Zhang W, Li X, Wang Y, Jiang Y, Lu Y, Tu P
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Dec;149:157546
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Dec;149:157546
Multi-Enzymatic Cascade Catalysis in Photodynamic Nanozymes for Augmenting Radiotherapy of Breast Cancer.
Cui G, Lu Z, Shi J, He X, Wang Y, Chen H, Jia Z, Chen J, Han J, He H, Guo Z
Advanced healthcare materials 2025 Dec;14(32):e02530
Advanced healthcare materials 2025 Dec;14(32):e02530
CBX2 and EZH2 cooperatively contribute to 5-Fu resistance in gastric cancer by suppressing ferroptosis via trimethylation of H3k27.
Zeng M, Li B, Guan Q, Cai H
Cellular signalling 2025 Dec;136:112078
Cellular signalling 2025 Dec;136:112078
Dauricine Inhibits Macrophages M2 Polarization and Regulates the Progression and Ferroptosis via HCK/IDO1 in Urinary Bladder Cancer.
Gong J, Sun D, Zheng Y, Mao C, Yu B, Li X, Xuan Y
Food science & nutrition 2025 Dec;13(12):e71341
Food science & nutrition 2025 Dec;13(12):e71341
Renal denervation attenuates cardiac dysfunction in HFpEF by inhibiting the ATP-P2X7-NLRP3 inflammasome axis.
Li Z, Sun X, Wang Y, Zhang F, Wang L, Ai C, Zhang X, Yin X, Liu C, Li C, Lu C
Basic research in cardiology 2025 Dec;120(6):1225-1247
Basic research in cardiology 2025 Dec;120(6):1225-1247
Erucic Acid, Derived by Lactobacillus Crispatus, Induces Ferroptosis in Cervical Cancer Organoids Through the PPAR-δ Signaling Pathway.
Zhen Q, Xu Y, Xu Y, Liu X, Zhang Y, Ye D, Han S, Liu S, Zhang Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(48):e12599
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(48):e12599
Norepinephrine Induces Sertoli Cell Ferroptosis via Receptors Desensitization Causing Stress-Related Male Reproductive Dysfunction.
Zhang L, Gao S, Xiong X, Liu X, Li R, Wang X, Han L, Xiao X, Wang X, Li W, Chang Y, Du Y, Yang J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(48):e04817
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(48):e04817
Exploring Functionally Enhanced BLP-Trained Macrophage Subpopulations in S. Aureus Infection: Underlying Mechanisms and Therapeutic Significance.
Wan Y, Hong Y, Ji X, Xiang J, Liu J, Liang L, Ren M, Chen W, Xu T, Li Z, Shi T, Jiang Y, Liang H, Liu J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(47):e17142
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(47):e17142
Tumor redox heterogeneity-responsive nanoparticles for enhanced antitumor efficacy through combining chemo/chemodynamic therapy.
Cui S, Yu L, Liu H, Liu W, Shi D
International journal of pharmaceutics: X 2025 Dec;10:100455
International journal of pharmaceutics: X 2025 Dec;10:100455
Investigating Nickel-Induced Neurotoxicity: Associations with Gut Microbiota Dysbiosis and Ferroptosis.
Shen Y, Cao K, Zhang W, Chen C, Gao C, Wang J, Xin T, Li C, Tang S, Pei X, Li D
Antioxidants (Basel, Switzerland) 2025 Dec 9;14(12)
Antioxidants (Basel, Switzerland) 2025 Dec 9;14(12)
Functional nano-nucleic acid platform promotes copper-induced gastric cancer cell death.
Zhang H, Ding B, Kou Q
RSC advances 2025 Dec 8;15(57):49643-49651
RSC advances 2025 Dec 8;15(57):49643-49651
Heterogeneity of active mast cells, endothelial cells, and fibroblasts in hemophilic arthritis defined by synovial single-cell sequencing.
Lin K, Fan S, Yang X, Hou W, Zhang J, Liao J, Han L, Peng P, Xiao F, Fang W, He X, Tian J, Lu S, Yang F, Wei Q, He M
Scientific reports 2025 Dec 8;15(1):43350
Scientific reports 2025 Dec 8;15(1):43350
Discovery of a selenium-containing compound as a promising ferroptosis inducer attenuates prostate cancer progression.
Xu L, Wang X, Xu Y, Wang Z, Li H, Che Z
European journal of medicinal chemistry 2025 Dec 5;299:118067
European journal of medicinal chemistry 2025 Dec 5;299:118067
Nicotinamide Mononucleotide Alleviates the Development of Fibrotic Cataract by Modulating the Nrf2/FPN1 Signaling Pathway.
Bao X, Pan Y, Xu Y, Xing Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Dec 31;39(24):e71348
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Dec 31;39(24):e71348
Echinacoside as a Novel Ferroptosis Inducer in Hepatocellular Carcinoma: Mechanistic Insights from TP53/SLC7A11/GPX4 Pathway Modulation.
Wang P, Lin J, Su D
International journal of molecular sciences 2025 Dec 30;27(1)
International journal of molecular sciences 2025 Dec 30;27(1)
CXCR4-engineered fibroblast membrane nanovesicles for Photothermal-enhanced ferroptotic therapy through chemokine-navigated tumor homing.
Bai L, Tan YN, Zhang LF, Luo M, Luo J, Yang YM, Liu YZ, Ho-Fun Lee V, Feng-Ming Kong S, Guan XY
Journal of nanobiotechnology 2025 Dec 30;24(1):102
Journal of nanobiotechnology 2025 Dec 30;24(1):102
The protective role of TRIM16 in rheumatoid arthritis: mechanisms of modulating ferroptosis.
Xu N, Fu W, Wu J, Zhao S, Tian C
International immunopharmacology 2025 Dec 3;166:115573
International immunopharmacology 2025 Dec 3;166:115573
TCF3 activates super-enhancer-driven TRIB2 overexpression to suppress ferroptosis and promote hepatoblastoma proliferation.
Wu H, Zhu G, Zhu Q, Ma J, Mao S, Ding M, Zhu J, Tang X, Bian Z, Shan Y, Gu S, Sun F, Jiang C, Pan Q
Journal of experimental & clinical cancer research : CR 2025 Dec 29;44(1):329
Journal of experimental & clinical cancer research : CR 2025 Dec 29;44(1):329
Cytochrome c Oxidase Subunit COX4-1 Reprograms Erastin-Induced Cell Death from Ferroptosis to Apoptosis: A Transmitochondrial Study.
Oliva CR, Flor S, Griguer CE
Antioxidants (Basel, Switzerland) 2025 Dec 28;15(1)
Antioxidants (Basel, Switzerland) 2025 Dec 28;15(1)
α-Linolenic Acid Alleviates Diabetic Cardiomyopathy by Activating AMPK-STAT3 Pathway to Inhibit Ferritinophagy and Enhance SLC7A11-GPX4 Antioxidant Axis.
Zhang Z, Bai X, Du Q, Yang J
Molecules (Basel, Switzerland) 2025 Dec 24;31(1)
Molecules (Basel, Switzerland) 2025 Dec 24;31(1)
Senescence-Primed Ferroptosis Enabled by a Metal-Organic Framework Nanoplatform for Enhanced Cancer Therapy.
Yang Z, Peng Y, Zang J, Wang J, Wang Z, Zhang G, Sun J, Chen H, Xie Y, Peng X, Shan X, Wang Y, Zhang L, Li Y
ACS nano 2025 Dec 23;19(50):42689-42704
ACS nano 2025 Dec 23;19(50):42689-42704
NEDD4 suppresses ferroptosis in lung ischemia-reperfusion injury by ubiquitinating and degrading SLC1A5.
Li J, Meng F, Qian X, Chen S
Scientific reports 2025 Dec 23;16(1):2568
Scientific reports 2025 Dec 23;16(1):2568
Targeting the SMAD3/CISD2 axis suppresses bladder cancer progression by promoting ferroptosis in mesenchymal-like bladder cancer cells.
Sun Y, Wang J, Gu D, Lou H, Sun J, Cui Z, Kang W
Cell death & disease 2025 Dec 18;17(1):101
Cell death & disease 2025 Dec 18;17(1):101
Microglial RUNX1/RBM47 ablation inhibits neuronal ferroptosis via regulating the cGAS-STING-MEF2C pathway in mice with postoperative cognitive dysfunction.
Wang S, Wu Z, Song W, Zhang H, Bu X, Gao W, Wu K, Xia Z, Zhao B, Wang W
Communications biology 2025 Dec 17;8(1):1813
Communications biology 2025 Dec 17;8(1):1813
Synergistic Proteolysis Targeting Chimera Chemotherapy Conjugate for Potent Non-small Cell Lung Cancer Treatment.
Zhao Q, Zeng R, Bi T, Yang X, Wang T, Chen L, Huang J, Dai X, Xu H, Sun Q, Liu Z
ACS applied materials & interfaces 2025 Dec 17;17(50):67595-67608
ACS applied materials & interfaces 2025 Dec 17;17(50):67595-67608
The FAK-NRF2 Axis Alleviates DOX-Induced Cardiotoxicity by Inhibiting Ferroptosis.
Zhao Y, Chen M, Kong L, Wu S, Teng C, Hu S, Xie K, Du J, Zhu X, Wang P, Xu P
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Dec 15;39(23):e71289
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Dec 15;39(23):e71289
Design, synthesis, and biological evaluation of arctigenin derivatives as novel GPX4 inhibitors in colorectal cancer cells.
Wang YX, Zhu L, Zhang L, Bao F, Liao BZ, Li YL, Kong LY, Luo JG, Chen C
European journal of medicinal chemistry 2025 Dec 15;300:118181
European journal of medicinal chemistry 2025 Dec 15;300:118181
HPDA-based tubule-targeting nanoplatform alleviates oxidative stress and ferroptosis for the reversal of renal interstitial fibrosis.
Xiao Z, Luo P, Li G, Tan H, Zhou C, Zeng D, Chen Y, Li Y
Journal of nanobiotechnology 2025 Dec 13;24(1):57
Journal of nanobiotechnology 2025 Dec 13;24(1):57
Melanoma MHC-I-membrane-encapsulated Cu@ferrihydrite induces ferroptosis/cuproptosis and systematic immunity against tumor.
Yang R, Deng F, Gao Z, Li X, Huangfu S, Tian Q, Wang H, Liu H, Wang X, Chen Y, Yang Y, Cheng G, Zhang L
Journal of controlled release : official journal of the Controlled Release Society 2025 Dec 10;388(Pt 1):114281
Journal of controlled release : official journal of the Controlled Release Society 2025 Dec 10;388(Pt 1):114281
FERMT1 suppresses the ferroptosis of glioma cells by interacting with MBOAT2.
Pan Z, Ke C, Zhang B, Lin Q, Zheng H, Zheng S, Huang J, Hu W
Experimental cell research 2025 Dec 1;453(2):114794
Experimental cell research 2025 Dec 1;453(2):114794
Exercise training ameliorates high-fat diet-induced skeletal muscle atrophy and ferroptosis via downregulation of STING.
Xu Z, Ma Z, Ren H, Yang Y, Zhao X, Pan S, Tang J, Zhang B
Free radical biology & medicine 2025 Dec 1;240:373-383
Free radical biology & medicine 2025 Dec 1;240:373-383
Baicalein attenuates metabolic dysfunction-associated steatohepatitis by regulating macrophage ferroptosis through nuclear factor (erythroid-derived 2)-like 2 pathway.
Wang Y, Zhao Y, Zhao W, Chen H, Cao Z, Li H, Tang Y, Zhu X, Yao P
Free radical biology & medicine 2025 Dec 1;240:238-252
Free radical biology & medicine 2025 Dec 1;240:238-252
Curcumin derivatives as ferroptosis inducers: design, synthesis and anti breast cancer activity evaluation.
Wu N, Zhang Y, Yin X, Du P, Piao Y, Zhao J, Zhu J, Quan Z, Wu CZ, Jin L, Zhang C
Bioorganic & medicinal chemistry 2025 Dec 1;130:118374
Bioorganic & medicinal chemistry 2025 Dec 1;130:118374
Inhibition of Mettl3-mediated m6A RNA modification of HMGCS1 protects retinal ganglion cells from glutamate excitotoxicity-induced ferroptosis in a rat model of glaucoma.
Wang C, Feng L, Fang W, Zhang C, Zhang W, Zhu W, He Y, Xia Z, Song W, Xia X
International journal of surgery (London, England) 2025 Dec 1;111(12):9147-9165
International journal of surgery (London, England) 2025 Dec 1;111(12):9147-9165
Anticancer activity of Momordica charantia-derived extracellular vesicle-like particle against cervical cancer.
Yin Q, Sun B, Qi X, Wu C, Li M, Wang B, Xu Y, Li S, Huang L, Chen B, Qi S
Tissue & cell 2025 Aug;95:102897
Tissue & cell 2025 Aug;95:102897
Salidroside sensitizes Triple-negative breast cancer to ferroptosis by SCD1-mediated lipogenesis and NCOA4-mediated ferritinophagy.
Huang G, Cai Y, Ren M, Zhang X, Fu Y, Cheng R, Wang Y, Miao M, Zhu L, Yan T
Journal of advanced research 2025 Aug;74:589-607
Journal of advanced research 2025 Aug;74:589-607
A Common Mutation in the Homeostatic Iron Regulatory Gene Alters Astrocyte Migration and Redox Profile.
Nolt M, Neely E, Kheirabadi S, Jaberi A, Sheikhi A, Connor J
FASEB bioAdvances 2025 Aug;7(8):e70042
FASEB bioAdvances 2025 Aug;7(8):e70042
Arbutin Preserves Boar Sperm During Storage at 17°C by Enhancing the Antioxidant Capacity via the NRF2/GPX4 Signalling.
Liu W, Li W, Lin R, Wang Y, Zhou P, Pang W, Li R, Zheng Y
Reproduction in domestic animals = Zuchthygiene 2025 Aug;60(8):e70103
Reproduction in domestic animals = Zuchthygiene 2025 Aug;60(8):e70103
SGLT2i continuously prevents cardiac hypertrophy by reducing ferroptosis via AMPK up-regulation.
Zhao BB, Wang J, Zhang LL, Li C, Xue HH, Zhao L, Han QH, Shi HT
Molecular and cellular biochemistry 2025 Aug;480(8):4849-4864
Molecular and cellular biochemistry 2025 Aug;480(8):4849-4864
SETD5 facilitates stemness and represses ferroptosis via m6A-mediating PKM2 stabilization in non-small cell lung cancer.
Liu X, Cui Y, Gong J, Yu X, Cui Y, Xuan Y
Oncogene 2025 Aug;44(29):2474-2489
Oncogene 2025 Aug;44(29):2474-2489
Lactoferrin prevents heat stroke-induced intestinal barrier damage by reducing ferroptosis via regulating MAPK signaling pathway: In vitro and in vivo studies.
Li L, Wang Y, Pei Y, Chen J, Zhou J, Gong Y, You J, Cao Y, Chen J, Cai Y, Chang W, Ma J, Ma W, Li X, Song Q, Xu S
International journal of biological macromolecules 2025 Aug;319(Pt 2):145454
International journal of biological macromolecules 2025 Aug;319(Pt 2):145454
Excessive ultra-processed foods exposure aggravates ulcerative colitis via macrophage ferroptosis.
Pang X, Yan J, Lv X, Wang J, Chen Q, Qi Y, Xu X, Wang B, Cao H
Environment international 2025 Aug;202:109706
Environment international 2025 Aug;202:109706
GPX4 degradation contributes to heat stress-induced liver injury via chaperone-mediated autophagy.
Wang T, Liu X, Feng X, Zhang Z, Lv R, Feng W, Zhou Y, Liao X, Tang H, Xu M
Biochimica et biophysica acta. Molecular cell research 2025 Aug;1872(6):119988
Biochimica et biophysica acta. Molecular cell research 2025 Aug;1872(6):119988
Hydroxysafflor yellow A inhibits neuronal ferroptosis and ferritinophagy in ischemic stroke.
Wu Y, Yin L, Wang Z, Yuan S, Ma D, Wen C, Tian H, Xiao B, Ma C, Song L
Biochimica et biophysica acta. Molecular basis of disease 2025 Aug;1871(6):167867
Biochimica et biophysica acta. Molecular basis of disease 2025 Aug;1871(6):167867
F-box only protein 10 protects against kidney tubulointerstitial fibrosis by inhibiting ACSL4-mediated lipid peroxidation and ferroptosis.
Hu J, Ma F, Chen X, Lu X, Lu Y, Jiang Y
Cellular signalling 2025 Aug;132:111841
Cellular signalling 2025 Aug;132:111841
Targeting GPX4 to Induce Ferroptosis Overcomes Chemoresistance Mediated by the PAX8-AS1/GPX4 Axis in Intrahepatic Cholangiocarcinoma.
Chen ZW, Shan JJ, Chen M, Wu Z, Zhao YM, Zhu HX, Jin X, Wang YX, Wu YB, Xiang Z, Ding ZW, Lin ZH, Wang LR, Wang L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(30):e01042
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(30):e01042
FSP1 and CoQ10 have the potential to serve as biomarkers for severe preeclampsia.
Li P, Liu Y, Liao J, Rao M, Peng L, Wang Y, Shang L, Liu X, Xiao Z
BMC pregnancy and childbirth 2025 Aug 6;25(1):813
BMC pregnancy and childbirth 2025 Aug 6;25(1):813
TCF7L2 regulates GPX4 to resist ferroptosis and enhance osteogenesis in mouse mesenchymal stem cells.
Lei M, Liu B, Wan B, Feng Y, Teng Y, Xi D, Zeng G, Zong S
European journal of medical research 2025 Aug 5;30(1):713
European journal of medical research 2025 Aug 5;30(1):713
Inhibition of ferroptosis in inflammatory macrophages alleviates intestinal injury in neonatal necrotizing enterocolitis.
Shen L, Chen J, Tou J
Cell death discovery 2025 Aug 5;11(1):365
Cell death discovery 2025 Aug 5;11(1):365
FTO-mediated the destabilization of RASGRF1 mRNA impedes thyroid cancer progression and suppresses macrophage M2 polarization.
Li Z, Ma J, Guan H, Lai J, Xu F, Cao G
Cell biology and toxicology 2025 Aug 4;41(1):123
Cell biology and toxicology 2025 Aug 4;41(1):123
Trimethylamine N-oxide Induced Chronic Kidney Injury by Triggering PANoptosis.
Shao D, Bai L, Chen Q, Chen Y, Qiu Z, Liu Y, Jin S, Wu Y, Dai J
Physiological research 2025 Aug 31;74(4):613-622
Physiological research 2025 Aug 31;74(4):613-622
WTAP Dysregulation Mediates HLF-m6A Modification to Inhibit Trophoblast Ferroptosis in Preeclampsia.
Liu S, Zhang L, Li Y, Jia X, Kang J, Sun M, Zhang X, Tang J, Meng T
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Aug 31;39(16):e70961
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Aug 31;39(16):e70961
Maimendong decoction and its active ingredient, ophiopogonin D, alleviate bleomycin-induced pulmonary fibrosis by regulating the behavior of lung fibroblasts.
Yang M, Zhang X, Bao S, Yang S, Zhang Y, Liu Y, Li C, Zou J, Li J, Yan S
Chinese medicine 2025 Aug 29;20(1):135
Chinese medicine 2025 Aug 29;20(1):135
Cancer-associated fibroblast-derived fibulin-5 promotes radioresistance in non-small-cell lung cancer.
Zhang R, Yan W, Yuan J, Ma Y, Ren Z, Chen X, Lv J, Wu M, Yu J, Chen D
Cell reports 2025 Aug 26;44(8):116018
Cell reports 2025 Aug 26;44(8):116018
USP18 promotes ferroptosis in lipopolysaccharide-induced human kidney organoids by stabilizing STING1.
Yang H, Zhao L, Kong W, Liu S, Zhou Q, Lang X, Lan L, Wang Y
Cell biology and toxicology 2025 Aug 20;41(1):126
Cell biology and toxicology 2025 Aug 20;41(1):126
METTL5 regulates SEPHS2-mediated selenoprotein synthesis to promote multiple myeloma survival and progression.
Jiang J, Zhong F, Xiao Z, Yao F, Liu J, Li M, Zeng H, Qiu Y, Zhang J, Zhang H, Li S, Huang T, Feng W, Huang Z, Huang B, Wang X
Cell death & disease 2025 Aug 2;16(1):585
Cell death & disease 2025 Aug 2;16(1):585
Effect of Self-Assembled Polydopamine Nanoparticles on Ferroptosis in an MPTP-Induced Parkinson's Disease Mice Model.
Xu Q, Xie D, Qie X, Chi B, Liu H
ACS applied bio materials 2025 Aug 18;8(8):7410-7419
ACS applied bio materials 2025 Aug 18;8(8):7410-7419
TIPE2 suppresses ferroptosis and pro-inflammatory polarization in macrophages triggered by SARS-CoV-2 spike protein.
Zhu S, Li W, Hao Y, Zhang L, Gao P
Scientific reports 2025 Aug 18;15(1):30246
Scientific reports 2025 Aug 18;15(1):30246
Recharacterization of the Tumor Suppressive Mechanism of RSL3 Identifies the Selenoproteome as a Druggable Pathway in Colorectal Cancer.
DeAngelo SL, Zhao L, Dziechciarz S, Shin M, Solanki S, Balia A, El-Derany MO, Castillo C, Qin Y, Das NK, Bell HN, Paulo JA, Zhang Y, Rossiter NJ, McCulla EC, He J, Talukder I, Ng BW, Schafer ZT, Neamati N, Mancias JD, Koutmos M, Shah YM
Cancer research 2025 Aug 1;85(15):2788-2804
Cancer research 2025 Aug 1;85(15):2788-2804
Exosomal SLC1A5 from senescent endothelial cells promotes gastric cancer progression by dampening ferroptosis via the EGFR/SRC/YAP1/GPX4 signaling.
Zhang Y, Ren Y, Wang Z, Zhang X, Li X, Yu Y, Qian L, Xiong Y
Free radical biology & medicine 2025 Aug 1;235:25-42
Free radical biology & medicine 2025 Aug 1;235:25-42
Fut8 regulated Unc5b hyperfucosylation reduces macrophage emigration and accelerates atherosclerosis development via the ferroptosis pathway.
Liu R, Dai L, Jia S, Geng S, Niu Y, Chen J, Dong C, Li C, Shi Y, Wang X, Zhang J, Zhao N, Gao Z, Yang X, Gao S
Free radical biology & medicine 2025 Aug 1;235:1-14
Free radical biology & medicine 2025 Aug 1;235:1-14
Dental pulp stem cells derived exosomes inhibit ferroptosis via regulating the Nrf2-keap1/GPX4 signaling pathway to ameliorate chronic kidney disease injury.
Luo L, Wang J, Zhao J, Yang B, Ma W, Lin J
Tissue & cell 2025 Apr;93:102670
Tissue & cell 2025 Apr;93:102670
Quercetin alleviates LPS/iE-DAP-induced liver injury by suppressing ferroptosis via regulating ferritinophagy and intracellular iron efflux.
Zhang H, Shi H, Li X, Zhou S, Song X, Ma N, Meng M, Chang G, Shen X
Redox biology 2025 Apr;81:103557
Redox biology 2025 Apr;81:103557
Histone lactylation drives liver cancer metastasis by facilitating NSF1-mediated ferroptosis resistance after microwave ablation.
Huang J, Xie H, Li J, Huang X, Cai Y, Yang R, Yang D, Bao W, Zhou Y, Li T, Lu Q
Redox biology 2025 Apr;81:103553
Redox biology 2025 Apr;81:103553
TGF-β1 induces ROS to activate ferroptosis via the ERK1/2-WISP1 pathway to promote the progression of renal tubular epithelial cell fibrosis.
Zhou Y, Luan F, Feng X, Yu M, Li L, Guo X, Yin X
Cytotechnology 2025 Apr;77(2):61
Cytotechnology 2025 Apr;77(2):61
Esketamine alleviated cardiomyocyte ferroptosis induced by oxygen-glucose deprivation/reoxygenation (OGD/R) via cyclic GMP-AMP synthase interactor.
Ouyang J, Xiao W, Wu D, Bai M, Zhao Q, Li Y
Cytotechnology 2025 Apr;77(2):57
Cytotechnology 2025 Apr;77(2):57
Caffeine improves hypoxia/reoxygenation induced neuronal cell injury through inhibiting cellular ferroptosis: an in vitro study.
Jia H, Fan H, Liang J, He R
Neurological research 2025 Apr;47(4):242-250
Neurological research 2025 Apr;47(4):242-250
Heliox alleviates ischemia-reperfusion-induced damage to neuronal cells by repressing the USP46-SNX5 Axis-triggered ferroptosis.
Yang H, Wang Z, Xiong W, Zhou L, Yu S
Experimental neurology 2025 Apr;386:115175
Experimental neurology 2025 Apr;386:115175
Hyaluronic acid-functionalized nanoparticles enable enhanced chemo/chemodynamic therapy for the targeted treatment of colon cancer.
Liu S, Tong S, Liu G, Wang S, Zhang K, Qiu Z
International journal of biological macromolecules 2025 Apr;303:140553
International journal of biological macromolecules 2025 Apr;303:140553
FePt/MnO(2)@PEG Nanoparticles as Multifunctional Radiosensitizers for Enhancing Ferroptosis and Alleviating Hypoxia in Osteosarcoma Therapy.
Han Z, Wang Y, Zang X, Liu H, Su J, Zhou Y
IEEE transactions on nanobioscience 2025 Apr;24(2):180-190
IEEE transactions on nanobioscience 2025 Apr;24(2):180-190
Nrf2 alleviates acute ischemic stroke induced ferroptosis via regulating xCT/GPX4 pathway.
Ye Y, Xie X, Bi Y, Liu Q, Qiu L, Zhao H, Wang C, Zhu W, Zeng T
Free radical biology & medicine 2025 Apr;231:153-162
Free radical biology & medicine 2025 Apr;231:153-162
Pharmacological Inhibition of TXNRD1 by a Small Molecule Flavonoid Butein Overcomes Cisplatin Resistance in Lung Cancer Cells.
Yang R, Sun S, Zhang Q, Liu H, Wang L, Meng Y, Chen N, Wang Z, Liu H, Ji F, Dai Y, He G, Xu W, Ye Z, Zhang J, Ma Q, Xu J
Biological trace element research 2025 Apr;203(4):1949-1960
Biological trace element research 2025 Apr;203(4):1949-1960
Amino-modified IONPs potentiates ferroptotic cell death due to the release of Fe ion in the lysosome.
Qi Z, Huang X, Jing J, Feng W, Xu M, Yan L, Gao M, Liu S, Yu XF
Journal of environmental sciences (China) 2025 Apr;150:1-13
Journal of environmental sciences (China) 2025 Apr;150:1-13
β-Diketone Functionalized Microspheres Chelate Reactive Iron via Metal Coordination for Cartilage Repair.
Xu Y, Gu X, Li X, Chen Y, Wei Z, Wang J, Liu Y, Ji Y, Cheng Q, Jiang S, Yu J, Li X, Cui W, Ye X
Advanced healthcare materials 2025 Apr;14(10):e2403933
Advanced healthcare materials 2025 Apr;14(10):e2403933
Elevated serum levels of GPX4, NDUFS4, PRDX5, and TXNRD2 as predictive biomarkers for castration resistance in prostate cancer patients: an exploratory study.
Wang R, Wang S, Mi Y, Huang T, Wang J, Ni J, Wang J, Yin J, Li M, Ran X, Fan S, Sun Q, Tan SY, Phillip Koeffler H, Ding L, Chen YQ, Feng N
British journal of cancer 2025 Apr;132(6):543-557
British journal of cancer 2025 Apr;132(6):543-557
Canagliflozin-induced renal glutathione distribution mapping in non-diabetic male rat kidneys.
Watanabe G, Horita S, Moriya RF, Masuishi Y, Misaka S, Taira S, Shimomura K, Shimabukuro M, Kazama JJ
Physiological reports 2025 Apr;13(7):e70320
Physiological reports 2025 Apr;13(7):e70320
Dapagliflozin alleviates high-fat-induced obesity cardiomyopathy by inhibiting ferroptosis.
Chen D, Shi J, Wu Y, Miao L, Wang Z, Wang Y, Xu S, Lou Y
ESC heart failure 2025 Apr;12(2):1358-1373
ESC heart failure 2025 Apr;12(2):1358-1373
3-D Sustained-Release Culture Carrier Alleviates Rat Intervertebral Disc Degeneration by Targeting STING in Transplanted Skeletal Stem Cells.
Luo L, Zhang S, Gong J, Zhang J, Xie P, Yin J, Zhang M, Zhang C, Chen H, Liu Y, Ni B, Li C, Tian Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(15):e2410151
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(15):e2410151
Short-term effects of subacute ruminal acidosis on ferroptosis and iron metabolism in the livers of lactating sheep fed a high-grain diet.
Zhang H, Shi H, Zhou S, Meng M, Ma N, Chang G, Shen X
Journal of dairy science 2025 Apr;108(4):4365-4380
Journal of dairy science 2025 Apr;108(4):4365-4380
Tanshinone IIA Ameliorates Myocardial Ischemia-Reperfusion Injury via Activating HDAC1-Repressed Nrf2-xCT/Gpx4/HO-1 Axis.
Yan K, Yu S, Gao X, Li L, Ding L
Chemical biology & drug design 2025 Apr;105(4):e70095
Chemical biology & drug design 2025 Apr;105(4):e70095
New insights into ovarian regression-related mitochondrial dysfunction in the late-laying period.
Gu T, Liu J, Zeng T, Chen L, Tian Y, Xu W, Lu L
Poultry science 2025 Apr;104(4):104938
Poultry science 2025 Apr;104(4):104938
Tangshenning formula alleviates tubular injury in diabetic kidney disease via the Sestrin2/AMPK/PGC-1α axis: Restoration of mitochondrial function and inhibition of ferroptosis.
Shan XM, Lu C, Chen CW, Wang CT, Liu TT, An T, Zhu ZY, Zou DW, Gao YB
Journal of ethnopharmacology 2025 Apr 9;345:119579
Journal of ethnopharmacology 2025 Apr 9;345:119579
The long noncoding RNA APR attenuates PPRV infection-induced accumulation of intracellular iron to inhibit membrane lipid peroxidation and viral replication.
Wen B, Chang W, Yang L, Lv D, Wang L, Wang L, Xu Y, Hu J, Ding K, Xue Q, Qi X, Yang B, Wang J
mBio 2025 Apr 9;16(4):e0012725
mBio 2025 Apr 9;16(4):e0012725
Mechanism of Mitophagy to Protect Yak Kidney from Hypoxia-Induced Fibrosis Damage by Regulating Ferroptosis Pathway.
Bai X, Lu H, Ma R, Yu S, Yang S, He J, Cui Y
Biomolecules 2025 Apr 9;15(4)
Biomolecules 2025 Apr 9;15(4)
Pharmacological targeting of the mitochondrial phosphatase PTPMT1 sensitizes hepatocellular carcinoma to ferroptosis.
Li M, Wang Y, Li X, Xu J, Yan L, Tang S, Liu C, Shi M, Liu R, Zhao Y, Zhang Y, Yang L, Zhang Y, Wang G, Li Z, Guo Y, Feng Y, Liu P
Cell death & disease 2025 Apr 6;16(1):257
Cell death & disease 2025 Apr 6;16(1):257
Inhibition of mitochondrial complex I induces mitochondrial ferroptosis by regulating CoQH2 levels in cancer.
Deng R, Fu L, Liang H, Ai X, Liu F, Li N, Wu L, Li S, Yang X, Lin Y, Huang Y, Yun J
Cell death & disease 2025 Apr 5;16(1):254
Cell death & disease 2025 Apr 5;16(1):254
Notopterol mitigates osteoarthritis progression and relieves pain in mice by inhibiting PI3K/Akt/GPX4-mediated ferroptosis.
Zhou X, Pan Y, Li J, Zhuang R, Tong P, Xia H
International immunopharmacology 2025 Apr 4;151:114323
International immunopharmacology 2025 Apr 4;151:114323
Identification of HCAR1 as a ferroptosis-related biomarker of gastric cancer based on a novel ferroptosis-related prognostic model and in vitro experiments.
Zhang H, Zhan J, Zhou J, Liu L, He Y, Le Y, Liu W, Zhou L, Liu Y, Xiang X
Carcinogenesis 2025 Apr 3;46(2)
Carcinogenesis 2025 Apr 3;46(2)
Impact of diabetes and metformin on cuproptosis and ferroptosis in breast cancer patients: an immunohistochemical analysis.
Li C, Chen T, Li Y, Zhou C, Du J, Li X, Tang C, Ma C, Deng N, Cui H
Discover oncology 2025 Apr 29;16(1):634
Discover oncology 2025 Apr 29;16(1):634
TAZ/NRF2 positive feedback loop contributes to proliferation in bladder cancer through antagonistic ferroptosis.
Song Z, Gui S, Rao X, Zhang G, Cheng Y, Zeng T
Cell death discovery 2025 Apr 29;11(1):208
Cell death discovery 2025 Apr 29;11(1):208
Inhibition of ferroptosis alleviates atherosclerosis and foam cell formation by regulating lipid metabolism via AMPK activation.
Yang Y, Chen Z, Song D, Wu J, Wang J, YouyouYan
International immunopharmacology 2025 Apr 24;153:114553
International immunopharmacology 2025 Apr 24;153:114553
Transcription factor FOS promotes ferroptosis and inflammation in S. aureus- infected osteomyelitis via EIF5A.
Gao L, Tang Z, Zhang Z, Wei D, Wang J
Journal of orthopaedic surgery and research 2025 Apr 23;20(1):412
Journal of orthopaedic surgery and research 2025 Apr 23;20(1):412
Electroacupuncture improves cognitive function in high-fat diet/streptozocin-induced type 2 diabetic mice by inhibiting autophagy-related ferroptosis.
Wang J, Huang Z, Li Y, Li Q, Li X, Chen L
Experimental animals 2025 Apr 20;74(2):197-208
Experimental animals 2025 Apr 20;74(2):197-208
RNF128 promotes gastric cancer progression by inhibiting autophagy-dependent ferroptosis through Beclin1 ubiquitination.
Zhu Z, Chen Q, Song S, Peng S, Ding H, Li B, Liu C, Jin X, Li L, Zhu J, Zhang G
Cell death discovery 2025 Apr 19;11(1):187
Cell death discovery 2025 Apr 19;11(1):187
Unraveling the crucial role of SDF-1 in osteoarthritis progression: IL6/HIF-1α positive feedback and chondrocyte ferroptosis.
Yang T, Yang X, Wang G, Jia D, Li Y
International immunopharmacology 2025 Apr 16;152:114400
International immunopharmacology 2025 Apr 16;152:114400
FADS2 inhibits colorectal cancer cell proliferation by regulating ferroptosis through SLC7A11/GPX4.
Yang Q, Zhang H, Luo J, Yu H, Yang X, Wang C
Molecular biology reports 2025 Apr 15;52(1):394
Molecular biology reports 2025 Apr 15;52(1):394
Artesunate induces ferroptosis in osteosarcoma through NCOA4-mediated ferritinophagy.
Huang R, Xu R, Shi J, Yang Z, Zheng J, Wei D
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Apr 15;39(7):e70488
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Apr 15;39(7):e70488
Cold atmospheric plasma drives USP49/HDAC3 axis mediated ferroptosis as a novel therapeutic strategy in endometrial cancer via reinforcing lactylation dependent p53 expression.
Liu J, Li Y, Ma R, Chen Y, Wang J, Zhang L, Wang B, Zhang Z, Huang L, Zhang H, Wan J, Liu H
Journal of translational medicine 2025 Apr 15;23(1):442
Journal of translational medicine 2025 Apr 15;23(1):442
TMEM160 inhibits KEAP1 to suppress ferroptosis and induce chemoresistance in gastric cancer.
Huang C, Zeng Q, Chen J, Wen Q, Jin W, Dai X, Ruan R, Zhong H, Xia Y, Wu Z, Huang R, Zhang J, Yao Y, Li L, Lei W, Xiong J, Deng J
Cell death & disease 2025 Apr 13;16(1):287
Cell death & disease 2025 Apr 13;16(1):287
A Nutrient-Deficient Microenvironment Facilitates Ferroptosis Resistance via the FAM60A-PPAR Axis in Pancreatic Ductal Adenocarcinoma.
Pan H, Sun Y, Qian LH, Liao YN, Gai YZ, Huo YM, Li ZQ, Nie HZ
Research (Washington, D.C.) 2024;7:0300
Research (Washington, D.C.) 2024;7:0300
GPX4 inhibits apoptosis of thyroid cancer cells through regulating the FKBP8/Bcl-2 axis.
Dang T, Yu J, Yu Y, Jiang J, Shi Y, Yu S, Peng C, Min X, Xiong Y, Long P, Zhou W, Dai D
Cancer biomarkers : section A of Disease markers 2024;39(4):349-360
Cancer biomarkers : section A of Disease markers 2024;39(4):349-360
Berberine alleviates AGEs-induced ferroptosis by activating NRF2 in the skin of diabetic mice.
Jiang C, Lao G, Ran J, Zhu P
Experimental biology and medicine (Maywood, N.J.) 2024;249:10280
Experimental biology and medicine (Maywood, N.J.) 2024;249:10280
Connexin43 overexpression promoted ferroptosis and increased myocardial vulnerability to ischemia-reperfusion injury in type 1 diabetic mice.
Yang Y, Chen J, Zhou J, Zhou D, Zhang A, Jiang Y, Lin J, Xia W, Cai Y, Han R, Lu Y, Liu D, Xia Z
International journal of medical sciences 2024;21(12):2365-2378
International journal of medical sciences 2024;21(12):2365-2378
PRDX1 inhibits ferroptosis by binding to Cullin-3 as a molecular chaperone in colorectal cancer.
Song Y, Wang X, Sun Y, Yu N, Tian Y, Han J, Qu X, Yu X
International journal of biological sciences 2024;20(13):5070-5086
International journal of biological sciences 2024;20(13):5070-5086
Ferroptosis-related gene MAPK3 is associated with the neurological outcome after cardiac arrest.
Hou HX, Pang L, Zhao L, Xing J
PloS one 2024;19(6):e0301647
PloS one 2024;19(6):e0301647
Electroacupuncture ameliorates depression-like behaviors in rats with post-stroke depression by inhibiting ferroptosis in the prefrontal cortex.
Gao J, Song X, Feng Y, Wu L, Ding Z, Qi S, Yu M, Wu R, Zheng X, Qin Y, Tang Y, Wang M, Feng X, Zhang Q
Frontiers in neuroscience 2024;18:1422638
Frontiers in neuroscience 2024;18:1422638
Propofol and Dexmedetomidine Ameliorate Endotoxemia-Associated Encephalopathy via Inhibiting Ferroptosis.
Zhou Y, Yang Y, Yi L, Pan M, Tang W, Duan H
Drug design, development and therapy 2024;18:1349-1368
Drug design, development and therapy 2024;18:1349-1368
Gandouling Regulates Ferroptosis and Improves Neuroinflammation in Wilson's Disease Through the LCN2/NLRP3 Signaling Pathway.
Wen Y, Zhao C, Chen J, Tian L, Wu B, Xie W, Dong T
Journal of inflammation research 2024;17:5599-5618
Journal of inflammation research 2024;17:5599-5618
Artemether regulates liver glycogen and lipid utilization through mitochondrial pyruvate oxidation in db/db mice.
Weng W, Shen L, Yu X, Yuan R, Shao M, Han P, Sun H
American journal of translational research 2024;16(1):27-38
American journal of translational research 2024;16(1):27-38
miR-141-3p promotes paclitaxel resistance by attenuating ferroptosis via the Keap1-Nrf2 signaling pathway in breast cancer.
Duan WL, Wang XJ, Guo A, Gu LH, Sheng ZM, Luo H, Yang LX, Wang WH, Zhang BG
Journal of Cancer 2024;15(17):5622-5635
Journal of Cancer 2024;15(17):5622-5635
Polydatin protects against DSS-induced ulcerative colitis via Nrf2/Slc7a11/Gpx4-dependent inhibition of ferroptosis signalling activation.
Zheng S, Yin J, Wang B, Ye Q, Huang J, Liang X, Wu J, Yue H, Zhang T
Frontiers in pharmacology 2024;15:1513020
Frontiers in pharmacology 2024;15:1513020
Calycosin alleviates ferroptosis and attenuates doxorubicin-induced myocardial injury via the Nrf2/SLC7A11/GPX4 signaling pathway.
Han Q, Shi J, Yu Y, Yuan H, Guo Y, Liu X, Xue Y, Li Y
Frontiers in pharmacology 2024;15:1497733
Frontiers in pharmacology 2024;15:1497733
Shikonin suppresses proliferation of osteosarcoma cells by inducing ferroptosis through promoting Nrf2 ubiquitination and inhibiting the xCT/GPX4 regulatory axis.
Huang R, Chu D, Shi J, Xu R, Wang K
Frontiers in pharmacology 2024;15:1490759
Frontiers in pharmacology 2024;15:1490759
A novel hollow iron nanoparticle system loading PEG-Fe(3)O(4) with C5a receptor antagonist for breast cancer treatment.
Yang H, Li G, Zhang J, Zhao J, Zhao Y, Wu Y, Sun Z, Song S, Zou Y, Zou Z, Han X, Deng B, Wang L, Rao H, Xu G, Wang S, Guo S, Ding H, Shi Y, Wu Y, Chen J
Frontiers in immunology 2024;15:1466180
Frontiers in immunology 2024;15:1466180
Transcription factor MEF2D regulates aberrant expression of ACSL3 and enhances sorafenib resistance by inhibiting ferroptosis in HCC.
Li X, Chen S, Shi Y, Wang Y, Wang X, Lin Q, Wu C, Fang W, Sun P, Ma L
Frontiers in pharmacology 2024;15:1464852
Frontiers in pharmacology 2024;15:1464852
Combination decoction of Astragalus mongholicus and Salvia miltiorrhiza mitigates pressure-overload cardiac dysfunction by inhibiting multiple ferroptosis pathways.
Xu Q, Liu X, Chen Z, Guo C, Lu P, Zhang S, Wang X, Shen J
Frontiers in pharmacology 2024;15:1447546
Frontiers in pharmacology 2024;15:1447546
Multidimensional role of adapalene in regulating cell death in multiple myeloma.
Cao X, Xiang J, Zhang Q, Liu J, Zhou D, Xu Y, Xu P, Chen B, Bai H
Frontiers in pharmacology 2024;15:1415224
Frontiers in pharmacology 2024;15:1415224
LSD1 inhibition by tranylcypromine hydrochloride reduces alkali burn-induced corneal neovascularization and ferroptosis by suppressing HIF-1α pathway.
Deng Q, Gao Y, Wang Y, Mao J, Yan Y, Yang Z, Cong Y, Yang Y, Wan S
Frontiers in pharmacology 2024;15:1411513
Frontiers in pharmacology 2024;15:1411513
Rabeprazole suppressed gastric intestinal metaplasia through activation of GPX4-mediated ferroptosis.
Xie J, Liang X, Xie F, Huang C, Lin Z, Xie S, Yang F, Zheng F, Geng L, Xu W, Gong S, Xiang L
Frontiers in pharmacology 2024;15:1409001
Frontiers in pharmacology 2024;15:1409001
Discovery of ferroptosis-related genes in renal ischemia reperfusion and evaluate the potential impact on kidney transplantation.
Zhou Y, Yang Y, Wang B, Chen W, Wei Y, Wu R, Meng L, Lyu L
Frontiers in immunology 2024;15:1394477
Frontiers in immunology 2024;15:1394477
Surufatinib combined with photodynamic therapy induces ferroptosis to inhibit cholangiocarcinoma in vitro and in tumor models.
Huang YP, Wang YX, Zhou H, Liu ZT, Zhang ZJ, Xiong L, Zou H, Wen Y
Frontiers in pharmacology 2024;15:1288255
Frontiers in pharmacology 2024;15:1288255
Photoreceptor-targeted extracellular vesicles-mediated delivery of Cul7 siRNA for retinal degeneration therapy.
Guo D, Sun Y, Wu J, Ding L, Jiang Y, Xue Y, Ma Y, Sun F
Theranostics 2024;14(13):4916-4932
Theranostics 2024;14(13):4916-4932
Expression of GPX4 by oncolytic vaccinia virus can significantly enhance CD8(+)T cell function and its impact against pancreatic ductal adenocarcinoma.
Wei W, Tian L, Zheng X, Zhong L, Chen Y, Dong H, Zhang G, Wang S, Tong X
Oncoimmunology 2024;13(1):2322173
Oncoimmunology 2024;13(1):2322173
Propofol and salvianolic acid A synergistically attenuated cardiac ischemia-reperfusion injury in diabetic mice via modulating the CD36/AMPK pathway.
Zhou J, Xia W, Chen J, Han K, Jiang Y, Zhang A, Zhou D, Liu D, Lin J, Cai Y, Chen G, Zhang L, Xu A, Xu Y, Han R, Xia Z
Burns & trauma 2024;12:tkad055
Burns & trauma 2024;12:tkad055
NU7441, a selective inhibitor of DNA-PKcs, alleviates intracerebral hemorrhage injury with suppression of ferroptosis in brain.
Gong X, Peng C, Zeng Z
PeerJ 2024;12:e18489
PeerJ 2024;12:e18489
Unveiling the mechanism of photothermal therapy in acne man-agement: targeting sebaceous gland ferroptosis via umbilical cord mesenchymal stem cell membrane-encapsulated Au-Ag-PDA.
Wu R, Li J, Tian H, Song D, Zhao T, Tian Y, Zouboulis CC, Jiang J, Zhu M
Frontiers in bioengineering and biotechnology 2024;12:1426477
Frontiers in bioengineering and biotechnology 2024;12:1426477
TYMS Knockdown Suppresses Cells Proliferation, Promotes Ferroptosis via Inhibits PI3K/Akt/mTOR Signaling Pathway Activation in Triple Negative Breast Cancer.
Wang L, Wu Z, Wang Y, Chen C, Li Y, Dong H, Yao T, Jin G, Wang Z
Cell biochemistry and biophysics 2024 Sep;82(3):2717-2726
Cell biochemistry and biophysics 2024 Sep;82(3):2717-2726
Melatonin Alleviates Osteoarthritis by Regulating NADPH Oxidase 4-Induced Ferroptosis and Mitigating Mitochondrial Dysfunction.
Wang Q, Qi B, Shi S, Jiang W, Li D, Jiang X, Yi C
Journal of pineal research 2024 Sep;76(6):e12992
Journal of pineal research 2024 Sep;76(6):e12992
Vitamin E and GPX4 cooperatively protect treg cells from ferroptosis and alleviate intestinal inflammatory damage in necrotizing enterocolitis.
Luo S, Zeng Y, Chen B, Yan J, Ma F, Zhuang G, Hao H, Cao G, Xiao X, Li S
Redox biology 2024 Sep;75:103303
Redox biology 2024 Sep;75:103303
CREG1 attenuates doxorubicin-induced cardiotoxicity by inhibiting the ferroptosis of cardiomyocytes.
Liu D, Cheng X, Wu H, Song H, Bu Y, Wang J, Zhang X, Yan C, Han Y
Redox biology 2024 Sep;75:103293
Redox biology 2024 Sep;75:103293
Nanoparticles targeting OPN loaded with BY1 inhibits vascular restenosis by inducing FTH1-dependent ferroptosis in vascular smooth muscle cells.
Zhang Y, Zheng BY, Zhang QF, Zhao YN, Yu QM, Liu X, Ding SY, Qian SS, Wu H, Wu QY, Zhang YH, Zheng L, Zhang XH, Zhang HF, Hao YM, Lu JC, Wang L, Wen JK, Zheng B
Biomaterials 2024 Sep;309:122613
Biomaterials 2024 Sep;309:122613
Gandouling ameliorates liver injury in Wilson's disease through the inhibition of ferroptosis by regulating the HSF1/HSPB1 pathway.
Zhao C, Chen J, Tian L, Wen Y, Wu M, Tang L, Zhou A, Xie W, Dong T
Journal of cellular and molecular medicine 2024 Sep;28(17):e70018
Journal of cellular and molecular medicine 2024 Sep;28(17):e70018
NOX1 triggers ferroptosis and ferritinophagy, contributes to Parkinson's disease.
Wang H, Mao W, Zhang Y, Feng W, Bai B, Ji B, Chen J, Cheng B, Yan F
Free radical biology & medicine 2024 Sep;222:331-343
Free radical biology & medicine 2024 Sep;222:331-343
Elucidating the molecular mechanisms behind the therapeutic impact of median nerve stimulation on cognitive dysfunction post-traumatic brain injury.
Zhong YJ, Liu LL, Zhao Y, Feng Z, Liu Y
Experimental gerontology 2024 Sep;194:112500
Experimental gerontology 2024 Sep;194:112500
MiR-1909-5p targeting GPX4 affects the progression of aortic dissection by modulating nicotine-induced ferroptosis.
Tao Y, Li G, Wang Z, Wang S, Peng X, Tang G, Li X, Liu J, Yu T, Fu X
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Sep;191:114826
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Sep;191:114826
Identification and validation of ferroptosis-related hub genes and immune infiltration in liver ischemia-reperfusion injury.
Li X, Meng Z, Hua Y, Li Z, Yin B, Qian B, Yu H, Li Z, Zhou Y, Feng Z, Lu S, Ke S, Bai M, Fu Y, Ma Y
Genomics 2024 Sep;116(5):110918
Genomics 2024 Sep;116(5):110918
RAB17 promotes endometrial cancer progression by inhibiting TFRC-dependent ferroptosis.
Zhou X, Nie M, Xin X, Hua T, Zhang J, Shi R, Dong K, Shu W, Yan B, Wang H
Cell death & disease 2024 Sep 6;15(9):655
Cell death & disease 2024 Sep 6;15(9):655
Prediction and verification of targets for α-hederin/oxaliplatin dual-loaded rHDL modified liposomes: Reversing effector T-cells dysfunction and improving anti-COAD efficiency in vitro and in vivo.
Wang G, Xu XN, Zhi-Min Z, Wang K, Li F
International journal of pharmaceutics 2024 Sep 5;662:124512
International journal of pharmaceutics 2024 Sep 5;662:124512
Aldo-Keto reductase 1C3 reduces myocardial cell damage after acute myocardial infarction by activating the Kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2-antioxidant response element pathway to inhibit ferroptosis.
Miao W, Hu YZ
Journal of geriatric cardiology : JGC 2024 Sep 28;21(9):899-912
Journal of geriatric cardiology : JGC 2024 Sep 28;21(9):899-912
Heat Shock Protein 90 Interactome-Mediated Proteolysis Targeting Chimera (HIM-PROTAC) Degrading Glutathione Peroxidase 4 to Trigger Ferroptosis.
Dong J, Ma F, Cai M, Cao F, Li H, Liang H, Li Y, Ding G, Li J, Cheng X, Qin JJ
Journal of medicinal chemistry 2024 Sep 26;67(18):16712-16736
Journal of medicinal chemistry 2024 Sep 26;67(18):16712-16736
Ursolic Acid Ameliorates Alcoholic Liver Injury through Attenuating Oxidative Stress-Mediated Ferroptosis and Modulating Gut Microbiota.
Zhou L, Xiao M, Li Y, Chitrakar B, Sheng Q, Zhao W
Journal of agricultural and food chemistry 2024 Sep 25;72(38):21181-21192
Journal of agricultural and food chemistry 2024 Sep 25;72(38):21181-21192
SGLT2 inhibition mitigates transition from acute kidney injury to chronic kidney disease by suppressing ferroptosis.
Hirashima Y, Nakano T, Torisu K, Aihara S, Wakisaka M, Kitazono T
Scientific reports 2024 Sep 2;14(1):20386
Scientific reports 2024 Sep 2;14(1):20386
Engineering Biodegradable Hollow Silica/Iron Composite Nanozymes for Breast Tumor Treatment through Activation of the "Ferroptosis Storm".
Xue P, Zhuang H, Shao S, Bai T, Zeng X, Yan S
ACS nano 2024 Sep 17;18(37):25795-25812
ACS nano 2024 Sep 17;18(37):25795-25812
Cerebroprotein hydrolysate-I ameliorates cognitive dysfunction in APP/PS1 mice by inhibiting ferroptosis via the p53/SAT1/ALOX15 signalling pathway.
Ren X, Wen Y, Yuan M, Li C, Zhang J, Li S, Zhang X, Wang L, Wang S
European journal of pharmacology 2024 Sep 15;979:176820
European journal of pharmacology 2024 Sep 15;979:176820
Ellagic acid ameliorates arsenic-induced neuronal ferroptosis and cognitive impairment via Nrf2/GPX4 signaling pathway.
Yang X, Chu F, Jiao Z, Yu H, Yang W, Li Y, Lu C, Ma H, Wang S, Liu Z, Qin S, Sun H
Ecotoxicology and environmental safety 2024 Sep 15;283:116833
Ecotoxicology and environmental safety 2024 Sep 15;283:116833
Co-delivery of siRNA and cisplatin via electrospun Nanofibrous membranes for synergistic treatment of malignant melanoma.
Zhang X, Zheng G, Zhou Z, Zhu M, Tang S
Heliyon 2024 Sep 15;10(17):e37517
Heliyon 2024 Sep 15;10(17):e37517
Oxidative stress induces ferroptosis in tendon stem cells by regulating mitophagy through cGAS-STING pathway.
Gao Y, Sun W, Wang J, Zhao D, Tian H, Qiu Y, Ji S, Wang S, Fu Q, Zhang F, Zhang Z, Wang F, Shao J, Zheng S, Meng J
International immunopharmacology 2024 Sep 10;138:112652
International immunopharmacology 2024 Sep 10;138:112652
Neuronal ferroptosis and ferroptosis-mediated endoplasmic reticulum stress: Implications in cognitive dysfunction induced by chronic intermittent hypoxia in mice.
Zhong P, Li L, Feng X, Teng C, Cai W, Zheng W, Wei J, Li X, He Y, Chen B, An X, Cai X
International immunopharmacology 2024 Sep 10;138:112579
International immunopharmacology 2024 Sep 10;138:112579
Autophagy aggravates multi-walled carbon nanotube-induced ferroptosis by suppressing PGC-1 dependent-mitochondrial biogenesis in lung epithelial cells.
Zhu L, Zhu D, Ran J, Li M, Lai Z, Zhou Y, Luo L, Liu X, Mao K, Tian K
Chemico-biological interactions 2024 Sep 1;400:111158
Chemico-biological interactions 2024 Sep 1;400:111158
Borna disease virus 1 induces ferroptosis, contributing to lethal encephalitis.
Tan Q, Yang H, He Y, Shen X, Sun L, Du X, Lin G, Zhou N, Wang N, Zhou Q, Liu D, Xu X, Zhao L, Xie P
Journal of medical virology 2024 Oct;96(10):e29945
Journal of medical virology 2024 Oct;96(10):e29945
Targeting GPX4-mediated ferroptosis protection sensitizes BRCA1-deficient cancer cells to PARP inhibitors.
Xie X, Chen C, Wang C, Guo Y, Sun B, Tian J, Yan J, Li D, Chen G
Redox biology 2024 Oct;76:103350
Redox biology 2024 Oct;76:103350
LOX-mediated ECM mechanical stress induces Piezo1 activation in hypoxic-ischemic brain damage and identification of novel inhibitor of LOX.
Jiang D, Zhao J, Zheng J, Zhao Y, Le M, Qin D, Huang Q, Huang J, Zhao Q, Wang L, Dong X
Redox biology 2024 Oct;76:103346
Redox biology 2024 Oct;76:103346
The Syvn1 inhibits neuronal cell ferroptosis by activating Stat3/Gpx4 axis in rat with spinal cord injury.
Xiao S, Zhang Y, Wang S, Liu J, Dan F, Yang F, Hong S, Liu N, Zeng Y, Huang K, Xie X, Zhong Y, Liu Z
Cell proliferation 2024 Oct;57(10):e13658
Cell proliferation 2024 Oct;57(10):e13658
Cytochrome P450 F3 promotes colorectal cancer via inhibiting NRF2-mediated ferroptosis.
Xu Z, Xu C, Lu J, He C, Wang X, Zhu D, Wang A, Zhang Z, Jiang C
Translational oncology 2024 Oct;48:102077
Translational oncology 2024 Oct;48:102077
Ferroptosis contributes to diabetes-induced visual pathway neuronal damage via iron accumulation and GPX4 inactivation.
Wang B, Jin Y, Ouyang X, Zhu R, Wang X, Li S, Jiang F
Metabolic brain disease 2024 Oct;39(7):1459-1468
Metabolic brain disease 2024 Oct;39(7):1459-1468
MEF2C Alleviates Postoperative Cognitive Dysfunction by Repressing Ferroptosis.
Wang S, Wu Z, Bu X, Peng X, Zhou Q, Song W, Gao W, Wang W, Xia Z
CNS neuroscience & therapeutics 2024 Oct;30(10):e70066
CNS neuroscience & therapeutics 2024 Oct;30(10):e70066
CuO Nanozymes Catalyze Cysteine and Glutathione Depletion Induced Ferroptosis and Cuproptosis for Synergistic Tumor Therapy.
Bai J, Zhang X, Zhao Z, Sun S, Cheng W, Yu H, Chang X, Wang B
Small (Weinheim an der Bergstrasse, Germany) 2024 Oct;20(40):e2400326
Small (Weinheim an der Bergstrasse, Germany) 2024 Oct;20(40):e2400326
FTO alleviated ferroptosis in septic cardiomyopathy via mediating the m6A modification of BACH1.
Zeng H, Xu J, Wu R, Wang X, Jiang Y, Wang Q, Guo J, Xiao F
Biochimica et biophysica acta. Molecular basis of disease 2024 Oct;1870(7):167307
Biochimica et biophysica acta. Molecular basis of disease 2024 Oct;1870(7):167307
Sulforaphane improves post-resuscitation myocardial dysfunction by inhibiting cardiomyocytes ferroptosis via the Nrf2/IRF1/GPX4 pathway.
Zheng Z, Xu J, Mao Y, Mei Z, Zhu J, Lan P, Wu X, Xu S, Zhang M
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Oct;179:117408
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Oct;179:117408
Artemether ameliorates acetaminophen-induced liver injury through Nrf2 pathway.
Yu S, Yang N, Li H, Hu X, Zhang L, Li S
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Oct;179:117280
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Oct;179:117280
Inhibition of HOXC11 by artesunate induces ferroptosis and suppresses ovarian cancer progression through transcriptional regulation of the PROM2/PI3K/AKT pathway.
Li J, Feng L, Yuan Y, He T, Zou X, Su B, Liu K, Yang X
World journal of surgical oncology 2024 Oct 8;22(1):268
World journal of surgical oncology 2024 Oct 8;22(1):268
Ferroptosis Regulated by 5-HT3a Receptor via Calcium/Calmodulin Signaling Contributes to Neuropathic Pain in Brachial Plexus Avulsion Rat Models.
Liao C, Guo J, Li S, Rui J, Gao K, Lao J, Zhou Y
ACS chemical neuroscience 2024 Oct 6;
ACS chemical neuroscience 2024 Oct 6;
GZMA suppressed GPX4-mediated ferroptosis to improve intestinal mucosal barrier function in inflammatory bowel disease.
Niu R, Lan J, Liang D, Xiang L, Wu J, Zhang X, Li Z, Chen H, Geng L, Xu W, Gong S, Yang M
Cell communication and signaling : CCS 2024 Oct 4;22(1):474
Cell communication and signaling : CCS 2024 Oct 4;22(1):474
MDH2 Promotes Hepatocellular Carcinoma Growth Through Ferroptosis Evasion via Stabilizing GPX4.
Yu W, Li Y, Gao C, Li D, Chen L, Dai B, Yang H, Han L, Deng Q, Bian X
International journal of molecular sciences 2024 Oct 29;25(21)
International journal of molecular sciences 2024 Oct 29;25(21)
Suppression of ferroptosis through the SLC7A11/glutathione/glutathione peroxidase 4 axis contributes to the therapeutic action of the Tangshenning formula on diabetic renal tubular injury.
Shan XM, Chen CW, Zou DW, Gao YB, Ba YY, He JX, Zhu ZY, Liang JJ
Chinese medicine 2024 Oct 29;19(1):151
Chinese medicine 2024 Oct 29;19(1):151
Hyperbaric Oxygen Improves Cognitive Impairment Induced by Hypoxia via Upregulating the Expression of Oleic Acid and MBOAT2 of Mice.
Li Z, Fu J, Jiang K, Gao J, Guo Y, Li C, Zhao L, Nam J, Gao H
Antioxidants (Basel, Switzerland) 2024 Oct 29;13(11)
Antioxidants (Basel, Switzerland) 2024 Oct 29;13(11)
The regulation of GSH/GPX4-mediated lipid accumulation confirms that schisandra polysaccharides should be valued equally as lignans.
Xue L, Wang L, Xu Y, Shen Y, Shi Z, Li X, Feng H, Xie X, Xie L, Wang G, Liang Y
Journal of ethnopharmacology 2024 Oct 28;333:118483
Journal of ethnopharmacology 2024 Oct 28;333:118483
A respiratory Streptococcus strain inhibits Acinetobacter baumannii from causing inflammatory damage through ferroptosis.
Sun Y, Li S, Che Y, Liang H, Guo Y, Xiao C
BMC microbiology 2024 Oct 28;24(1):437
BMC microbiology 2024 Oct 28;24(1):437
Human breast milk-derived phospholipid DOPE ameliorates intestinal injury associated with NEC by inhibiting ferroptosis.
Chen Y, Chen W, Dai Y, Yan X, Jiang C, Zhang F, Zhang M, Hu X, Zhao J, Wu T, Li S, Han S, Chen X
Food & function 2024 Oct 28;15(21):10811-10822
Food & function 2024 Oct 28;15(21):10811-10822
The effect of norepinephrine on ovarian dysfunction by mediating ferroptosis in mice model.
Hong H, Xiao C, Weng L, Wang Q, Lai D
Acta biochimica et biophysica Sinica 2024 Oct 22;57(4):542-553
Acta biochimica et biophysica Sinica 2024 Oct 22;57(4):542-553
Upregulation of PRRX2 by silencing Marveld3 as a protective mechanism against radiation-induced ferroptosis in skin cells.
Cao J, Wu M, Mo W, Zhao M, Gu L, Wang X, Zhang B, Cao J
Molecular medicine (Cambridge, Mass.) 2024 Oct 21;30(1):182
Molecular medicine (Cambridge, Mass.) 2024 Oct 21;30(1):182
AMPD3 promotes doxorubicin-induced cardiomyopathy through HSP90α-mediated ferroptosis.
Cheng L, Zhu M, Xu X, Li X, Yao Y, Liu C, He K
iScience 2024 Oct 18;27(10):111005
iScience 2024 Oct 18;27(10):111005
Magnetic-vortex nanodonuts enhance ferroptosis effect of tumor ablation through an imaging-guided hyperthermia/radiosensitization strategy.
Guo SS, Chen MM, Yang YH, Zhang YY, Pang X, Shi YP, Zhuang YC, Fan DD, Bao JF, Ji ZY
iScience 2024 Oct 18;27(10):110533
iScience 2024 Oct 18;27(10):110533
CD8+ T cell associated scoring model helps prognostic diagnosis and immunotherapy selection in patients with colon adenocarcinoma.
Zhao Z, Chen M, Sun K, Gu X
Heliyon 2024 Oct 15;10(19):e37998
Heliyon 2024 Oct 15;10(19):e37998
PRODH Regulates Tamoxifen Resistance through Ferroptosis in Breast Cancer Cells.
Zhang P, Qian N, Lai H, Chen S, Wu K, Luo X, Lei B, Liu M, Cui J
Genes 2024 Oct 14;15(10)
Genes 2024 Oct 14;15(10)
PF-PEG@ASIV-EXO Hydrogel Accelerates Diabetic Wound Healing by Ferroptosis Resistance and Promoting Angiogenesis.
Xiong W, Zhang X, Hu J, Zou X, Huang H, Qu W, Cai S, Li C, Wei Y, Zhong X, Cai Z, Huang Z
ACS biomaterials science & engineering 2024 Oct 14;10(10):6263-6285
ACS biomaterials science & engineering 2024 Oct 14;10(10):6263-6285
Iron-laden macrophage-mediated paracrine profibrotic signaling induces lung fibroblast activation.
Li Y, Du X, Hu Y, Wang D, Duan L, Zhang H, Zhang R, Xu Y, Zhou R, Zhang X, Zhang M, Liu J, Lv Z, Chen Y, Wang W, Sun Y, Cui Y
American journal of physiology. Cell physiology 2024 Oct 1;327(4):C979-C993
American journal of physiology. Cell physiology 2024 Oct 1;327(4):C979-C993
A precise microdissection strategy enabled spatial heterogeneity analysis on the targeted region of formalin-fixed paraffin-embedded tissues.
Chen C, Li Y, Wei W, Lu Y, Zou B, Zhang L, Shan J, Zhu Y, Wang S, Wu H, Su H, Zhou G
Talanta 2024 Oct 1;278:126501
Talanta 2024 Oct 1;278:126501
Serum apolipoprotein H determines ferroptosis resistance by modulating cellular lipid composition.
He X, Zhang J, Huang M, Wang J, Yang S, Yu X, Xu Y, Yang W
Cell death & disease 2024 Oct 1;15(10):718
Cell death & disease 2024 Oct 1;15(10):718
Unveiling the crucial role of ferroptosis in host resistance to streptococcus agalactiae infection.
Yi JX, Sun ZY, Liu P, Wang YH, Liu H, Lv QY, Kong DC, Huang WH, Ren YH, Li Q, Jiang YQ, Li J, Jiang H
Cell death discovery 2024 Oct 1;10(1):423
Cell death discovery 2024 Oct 1;10(1):423
Silibinin attenuates ferroptosis in acute kidney injury by targeting FTH1.
Deng Y, Zeng L, Liu H, Zuo A, Zhou J, Yang Y, You Y, Zhou X, Peng B, Lu H, Ji S, Wang M, Lai Y, Kwan HY, Sun X, Wang Q, Zhao X
Redox biology 2024 Nov;77:103360
Redox biology 2024 Nov;77:103360
Rituximab induces ferroptosis and RSL3 overcomes rituximab resistance in diffuse large B-cell lymphoma cells.
Wu H, Zou L, Jin Y, Wang G, Cho WC, Li W, Cai Y, Song G
Archives of biochemistry and biophysics 2024 Nov;761:110188
Archives of biochemistry and biophysics 2024 Nov;761:110188
Sodium citrate targeting Ca(2+)/CAMKK2 pathway exhibits anti-tumor activity through inducing apoptosis and ferroptosis in ovarian cancer.
Wu Y, Jia C, Liu W, Zhan W, Chen Y, Lu J, Bao Y, Wang S, Yu C, Zheng L, Sun L, Song Z
Journal of advanced research 2024 Nov;65:89-104
Journal of advanced research 2024 Nov;65:89-104
Ferritinophagy is involved in hexavalent chromium-induced ferroptosis in Sertoli cells.
Zhuge R, Zhang L, Xue Q, Wang R, Xu J, Wang C, Meng C, Lu R, Yin F, Guo L
Toxicology and applied pharmacology 2024 Nov;492:117139
Toxicology and applied pharmacology 2024 Nov;492:117139
USP14 increases the sensitivity of retinoblastoma to cisplatin by mediating the ferroptosis.
Liu H, Gan Q, Lai Y, Pan Z, Jin Q, Li J, Wang N, Jiao S, Chai Y
Naunyn-Schmiedeberg's archives of pharmacology 2024 Nov;397(11):8671-8680
Naunyn-Schmiedeberg's archives of pharmacology 2024 Nov;397(11):8671-8680
Intra-articular injection of platinum nanozyme-loaded silk fibroin/pullulan hydrogels relieves osteoarthritis through ROS scavenging and ferroptosis suppression.
Feng J, Deng X, Hao P, Zhu Z, Li T, Yuan X, Hu J, Wang Y
International journal of biological macromolecules 2024 Nov;280(Pt 2):135863
International journal of biological macromolecules 2024 Nov;280(Pt 2):135863
Cancer cell membrane-camouflaged curcumin nanoparticles trigger ferroptosis for accurate gastric cancer therapy.
Fan Y, Zhang X, Zhao J, Chen S, Liang J
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 2024 Nov;204:114509
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 2024 Nov;204:114509
Mn(II)-Aloe-Emodin Nanoscale Coordination Polymer Enhances Ferroptosis by Synergistically Enhancing Reactive Oxygen Species Generation via the Nrf2-GPX4 Axis.
Yang X, Li C, Ge M, Li X, Zhao W, Guo H, Nie H, Liu J
Advanced healthcare materials 2024 Nov;13(28):e2400474
Advanced healthcare materials 2024 Nov;13(28):e2400474
IL6 Derived from Macrophages under Intermittent Hypoxia Exacerbates NAFLD by Promoting Ferroptosis via MARCH3-Led Ubiquitylation of GPX4.
Cai W, Wu S, Ming X, Li Z, Pan D, Yang X, Yang M, Yuan Y, Chen X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Nov;11(41):e2402241
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Nov;11(41):e2402241
Role of PI3K/AKT signaling pathway involved in self-renewing and maintaining biological properties of chicken primordial germ cells.
Liu X, Ye L, Ding Y, Gong W, Qian H, Jin K, Niu Y, Zuo Q, Song J, Han W, Chen G, Li B
Poultry science 2024 Nov;103(11):104140
Poultry science 2024 Nov;103(11):104140
Repurposed genipin targeting UCP2 exhibits antitumor activity through inducing ferroptosis in glioblastoma.
Dong H, Sun K, Wang X, Cui M, Ma Y, Li K, Duan W, Zhang H, Zhang L, Sheng Z, He M, Zhang B
Acta biochimica et biophysica Sinica 2024 Nov 8;57(3):403-414
Acta biochimica et biophysica Sinica 2024 Nov 8;57(3):403-414
BRAF-Mutated Melanoma Cell Lines Develop Distinct Molecular Signatures After Prolonged Exposure to AZ628 or Dabrafenib: Potential Benefits of the Antiretroviral Treatments Cabotegravir or Doravirine on BRAF-Inhibitor-Resistant Cells.
Zanrè V, Bellinato F, Cardile A, Passarini C, Di Bella S, Menegazzi M
International journal of molecular sciences 2024 Nov 6;25(22)
International journal of molecular sciences 2024 Nov 6;25(22)
Iberverin Downregulates GPX4 and SLC7A11 to Induce Ferroptotic Cell Death in Hepatocellular Carcinoma Cells.
Yang H, Dai B, Chen L, Li Y, Jin X, Gao C, Han L, Bian X
Biomolecules 2024 Nov 5;14(11)
Biomolecules 2024 Nov 5;14(11)
MT1E in AML: a gateway to understanding regulatory cell death and immunotherapeutic responses.
Zhuang X, Chen P, Yang K, Yang R, Man X, Wang R, Shi Y
Journal of leukocyte biology 2024 Nov 27;116(6):1515-1529
Journal of leukocyte biology 2024 Nov 27;116(6):1515-1529
Role of ferroptosis in mitochondrial damage in diabetic retinopathy.
Malaviya P, Kumar J, Kowluru RA
Free radical biology & medicine 2024 Nov 20;225:821-832
Free radical biology & medicine 2024 Nov 20;225:821-832
25-Hydroxycholecalciferol Improves Cardiac Metabolic Adaption, Mitochondrial Biogenetics, and Redox Status to Ameliorate Pathological Remodeling and Functional Failure in Obese Chickens.
Chiang SK, Sin MY, Lin JW, Siregar M, Valdez G, Chen YH, Chung TK, Walzem RL, Chang LC, Chen SE
Antioxidants (Basel, Switzerland) 2024 Nov 20;13(11)
Antioxidants (Basel, Switzerland) 2024 Nov 20;13(11)
Fibroblast growth factor 21 improves diabetic cardiomyopathy by inhibiting ferroptosis via ferritin pathway.
Wang R, Zhang X, Ye H, Yang X, Zhao Y, Wu L, Liu H, Wen Y, Wang J, Wang Y, Yu M, Ma C, Wang L
Cardiovascular diabetology 2024 Nov 2;23(1):394
Cardiovascular diabetology 2024 Nov 2;23(1):394
Nutritional Glutamine-Modified Iron-Delivery System with Enhanced Endocytosis for Ferroptosis Therapy of Pancreatic Tumors.
Chen Y, Xu W, Jin H, Zhang M, Liu S, Liu Y, Zhang H
ACS nano 2024 Nov 19;18(46):31846-31868
ACS nano 2024 Nov 19;18(46):31846-31868
Huperzine A protected against ferroptosis via activating PI3K/Akt signaling in lipopolysaccharide induced acute lung injury.
Shi J, Chen W, Tang J, Zhang C, Qi M, Zheng X, Wang J, Liu Q, Liu L, Chen X, Han Z
European journal of pharmacology 2024 Nov 15;983:177004
European journal of pharmacology 2024 Nov 15;983:177004
Total extracts from Abelmoschus manihot (L.) alleviate radiation-induced cardiomyocyte ferroptosis via regulating redox imbalances mediated by the NOX4/xCT/GPX4 axis.
Xu Z, Wang Y, Yang W, Han W, Ma B, Zhao Y, Bao T, Zhang Q, Lin X
Journal of ethnopharmacology 2024 Nov 15;334:118582
Journal of ethnopharmacology 2024 Nov 15;334:118582
Carthamin yellow alleviates dextran sodium sulfate-induced ulcerative colitis by repairing the intestinal barrier and activating the Nrf2/GPX4 axis.
Bian W, Wei L, Wang K
International immunopharmacology 2024 Nov 15;141:113020
International immunopharmacology 2024 Nov 15;141:113020
Immune Checkpoint-Modulating Photosensitizer That Targets BRD4 for Cancer Photoimmunotherapy.
Li P, Du Y, Qiu J, Jiang Q, Chen W, Zhang X, Li G, Li D, Shan G
Journal of medicinal chemistry 2024 Nov 14;67(21):18930-18942
Journal of medicinal chemistry 2024 Nov 14;67(21):18930-18942
MDM4 inhibits ferroptosis in p53 mutant colon cancer via regulating TRIM21/GPX4 expression.
Liu J, Wei X, Xie Y, Yan Y, Xue S, Wang X, Chen H, Pan Q, Yan S, Zheng X, Huang Q
Cell death & disease 2024 Nov 14;15(11):825
Cell death & disease 2024 Nov 14;15(11):825
LncRNA MALAT1 promotes Erastin-induced ferroptosis in the HBV-infected diffuse large B-cell lymphoma.
Bai X, Li J, Guo X, Huang Y, Xu X, Tan A, Jia Y, Sun Q, Guo X, Chen J, Kang J
Cell death & disease 2024 Nov 12;15(11):819
Cell death & disease 2024 Nov 12;15(11):819
LncRNA MALAT1-Targeting Antisense Oligonucleotide Ameliorates the AngII-Induced Vascular Smooth Muscle Cell Proliferation and Migration Through Nrf2/GPX4 Antioxidant Pathway.
Liao Z, Ni Z, Cao J, Liao J, Zhu H, Zhong X, Cao G, Huang L, Li X, Jiang G, Pei F
Journal of cardiovascular pharmacology 2024 Nov 1;84(5):515-527
Journal of cardiovascular pharmacology 2024 Nov 1;84(5):515-527
Treatment of Parkinson's disease model with human umbilical cord mesenchymal stem cell-derived exosomes loaded with BDNF.
Wang CC, Hu XM, Long YF, Huang HR, He Y, Xu ZR, Qi ZQ
Life sciences 2024 Nov 1;356:123014
Life sciences 2024 Nov 1;356:123014
Platycodin D ameliorates polycystic ovary syndrome-induced ovarian damage by upregulating CD44 to attenuate ferroptosis.
Ji R, Wang S, Chen X, Yang Z, Zhang Z, Bao S, Xiao Z, Zhang Y, Yin T, Yang J
Free radical biology & medicine 2024 Nov 1;224:707-722
Free radical biology & medicine 2024 Nov 1;224:707-722
The effect of tau K677 lactylation on ferritinophagy and ferroptosis in Alzheimer's disease.
An X, He J, Xie P, Li C, Xia M, Guo D, Bi B, Wu G, Xu J, Yu W, Ren Z
Free radical biology & medicine 2024 Nov 1;224:685-706
Free radical biology & medicine 2024 Nov 1;224:685-706
Epithelial Piezo1 deletion ameliorates intestinal barrier damage by regulating ferroptosis in ulcerative colitis.
Zhu J, Wu Y, Zhang L, Bai B, Han W, Wang H, Mei Q
Free radical biology & medicine 2024 Nov 1;224:272-286
Free radical biology & medicine 2024 Nov 1;224:272-286
Identification of ROS and KEAP1-related genes and verified targets of α-hederin induce cell death for CRC.
Wang G, Zhu ZM, Wang K
Drug development research 2024 May;85(3):e22200
Drug development research 2024 May;85(3):e22200
Icariin‑curcumol promotes ferroptosis in prostate cancer cells through Nrf2/HO‑1 signaling.
Sheng W, Li B, Sun T, Zhu C, Li Y, Xu W
Experimental and therapeutic medicine 2024 May;27(5):232
Experimental and therapeutic medicine 2024 May;27(5):232
N-acetylcysteine Protects Against Myocardial Ischemia-Reperfusion Injury Through Anti-ferroptosis in Type 1 Diabetic Mice.
Zhou D, Yang Y, Chen J, Zhou J, He J, Liu D, Zhang A, Yuan B, Jiang Y, Xia W, Han R, Xia Z
Cardiovascular toxicology 2024 May;24(5):481-498
Cardiovascular toxicology 2024 May;24(5):481-498
Iron (II)-based metal-organic framework nanozyme for boosting tumor ferroptosis through inhibiting DNA damage repair and system Xc().
Xue P, Zhuang H, Bai T, Zeng X, Deng J, Shao S, Yan S
Journal of nanobiotechnology 2024 May 8;22(1):228
Journal of nanobiotechnology 2024 May 8;22(1):228
LncRNA-PVT1 Inhibits Ferroptosis through Activating STAT3/GPX4 Axis to Promote Osteosarcoma Progression.
Li G, Feng J, Huang S, Li Q
Frontiers in bioscience (Landmark edition) 2024 May 30;29(6):207
Frontiers in bioscience (Landmark edition) 2024 May 30;29(6):207
MiR-31-5p alleviates septic cardiomyopathy by targeting BAP1 to inhibit SLC7A11 deubiquitination and ferroptosis.
Liu Y, Hu N, Ai B, Xia H, Li W
BMC cardiovascular disorders 2024 May 30;24(1):286
BMC cardiovascular disorders 2024 May 30;24(1):286
Ficolin 3 promotes ferroptosis in HCC by downregulating IR/SREBP axis-mediated MUFA synthesis.
Yuan Y, Xu J, Jiang Q, Yang C, Wang N, Liu X, Piao HL, Lu S, Zhang X, Han L, Liu Z, Cai J, Liu F, Chen S, Liu J
Journal of experimental & clinical cancer research : CR 2024 May 3;43(1):133
Journal of experimental & clinical cancer research : CR 2024 May 3;43(1):133
αO-Conotoxin GeXIVA[1,2] Suppresses In Vivo Tumor Growth of Triple-Negative Breast Cancer by Inhibiting AKT-mTOR, STAT3 and NF-κB Signaling Mediated Proliferation and Inducing Apoptosis.
Guo X, He L, Xu W, Wang W, Feng X, Fu Y, Zhang X, Ding RB, Qi X, Bao J, Luo S
Marine drugs 2024 May 29;22(6)
Marine drugs 2024 May 29;22(6)
Label-Free Three-Dimensional Morphological Characterization of Cell Death Using Holographic Tomography.
Huang CH, Lai YJ, Chen LN, Hung YH, Tu HY, Cheng CJ
Sensors (Basel, Switzerland) 2024 May 26;24(11)
Sensors (Basel, Switzerland) 2024 May 26;24(11)
Exploring the anti-ferroptosis mechanism of Kai-Xin-San against Alzheimer's disease through integrating network pharmacology, bioinformatics, and experimental validation strategy in vivo and in vitro.
Yan C, Yang S, Shao S, Zu R, Lu H, Chen Y, Zhou Y, Ying X, Xiang S, Zhang P, Li Z, Yuan Y, Zhang Z, Wang P, Xie Z, Wang W, Ma H, Sun Y
Journal of ethnopharmacology 2024 May 23;326:117915
Journal of ethnopharmacology 2024 May 23;326:117915
Brusatol hinders the progression of bladder cancer by Chac1/Nrf2/SLC7A11 pathway.
Yu X, He Z, Wang Z, Ke S, Wang H, Wang Q, Li S
Experimental cell research 2024 May 15;438(2):114053
Experimental cell research 2024 May 15;438(2):114053
Cadmium exposure induced neuronal ferroptosis and cognitive deficits via the mtROS-ferritinophagy pathway.
Wang D, Wu Y, Zhou X, Liang C, Ma Y, Yuan Q, Wu Z, Hao X, Zhu X, Li X, Shi J, Chen J, Fan H
Environmental pollution (Barking, Essex : 1987) 2024 May 15;349:123958
Environmental pollution (Barking, Essex : 1987) 2024 May 15;349:123958
Ischemia-inhibited ferric chelate reductase 1 improves ferroptosis-mediated intestinal ischemia injury via Hippo signaling.
Liang P, Xie W, Wang X, Du Z, Zheng C, Zhao H, Wang Z, Ji Z
International immunopharmacology 2024 May 10;132:111900
International immunopharmacology 2024 May 10;132:111900
MiR-122-5p regulates erastin-induced ferroptosis via CS in nasopharyngeal carcinoma.
Guo L, Wang Z, Fu Y, Wu S, Zhu Y, Yuan J, Liu Y
Scientific reports 2024 May 1;14(1):10019
Scientific reports 2024 May 1;14(1):10019
Design, synthesis, and evaluation of formylpiperazine analogs of Ferrostatin-1 as novel improved ferroptosis inhibitors.
Ji HL, Zhang YF, Zhang NY, Wang KM, Meng N, Zhang J, Jiang CS
Bioorganic & medicinal chemistry 2024 May 1;105:117716
Bioorganic & medicinal chemistry 2024 May 1;105:117716
Therapeutic potential and mechanisms of Rifaximin in ameliorating iron overload-induced ferroptosis and liver fibrosis in vivo and in vitro.
Yuan Q, Fang Y, Guo J, Zhang Z, Liao J, Kuang J
Toxicology and applied pharmacology 2024 Mar;484:116845
Toxicology and applied pharmacology 2024 Mar;484:116845
Ca & Mn dual-ion hybrid nanostimulator boosting anti-tumor immunity via ferroptosis and innate immunity awakening.
Deng X, Liu T, Zhu Y, Chen J, Song Z, Shi Z, Chen H
Bioactive materials 2024 Mar;33:483-496
Bioactive materials 2024 Mar;33:483-496
Glutathione depletion and dihydroorotate dehydrogenase inhibition actuated ferroptosis-augment to surmount triple-negative breast cancer.
Zhou TJ, Zhang MM, Liu DM, Huang LL, Yu HQ, Wang Y, Xing L, Jiang HL
Biomaterials 2024 Mar;305:122447
Biomaterials 2024 Mar;305:122447
The opposite role of lactate dehydrogenase a (LDHA) in cervical cancer under energy stress conditions.
Jia C, Wu Y, Gao F, Liu W, Li N, Chen Y, Sun L, Wang S, Yu C, Bao Y, Song Z
Free radical biology & medicine 2024 Mar;214:2-18
Free radical biology & medicine 2024 Mar;214:2-18
Sestrin2 reduces ferroptosis via the Keap1/Nrf2 signaling pathway after intestinal ischemia-reperfusion.
Zhang LL, Ding K, Liao SS, Zhang YG, Liao HY, Chen R, Meng QT
Free radical biology & medicine 2024 Mar;214:115-128
Free radical biology & medicine 2024 Mar;214:115-128
Propionate promotes ferroptosis and apoptosis through mitophagy and ACSL4-mediated ferroptosis elicits anti-leukemia immunity.
Wei Y, Liu W, Wang R, Chen Y, Liu J, Guo X, Can C, Yang X, Wang D, Hu X, Ma D
Free radical biology & medicine 2024 Mar;213:36-51
Free radical biology & medicine 2024 Mar;213:36-51
Enhanced glutathione production protects against zearalenone-induced oxidative stress and ferroptosis in female reproductive system.
Fu W, Dai C, Ma Z, Li Q, Lan D, Sun C, Wu X, Li J, Wang S
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Mar;185:114462
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Mar;185:114462
DTTZ suppresses ferroptosis and reverses mitochondrial dysfunction in normal tissues affected by chemotherapy.
Yang Y, Chen Y, Tang H, Zhang Z, Zhou X, Xu W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Mar;172:116227
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Mar;172:116227
Design, Synthesis, and Biological Evaluation of Hydrophobic-Tagged Glutathione Peroxidase 4 (GPX4) Degraders.
Li X, Hu M, Zhang Y, Hua H, Sun Y, Xiang Q, Zhu D
Bioorganic chemistry 2024 Mar;144:107115
Bioorganic chemistry 2024 Mar;144:107115
GSTM3 enhances radiosensitivity of nasopharyngeal carcinoma by promoting radiation-induced ferroptosis through USP14/FASN axis and GPX4.
Chen Y, Feng Y, Lin Y, Zhou X, Wang L, Zhou Y, Lin K, Cai L
British journal of cancer 2024 Mar;130(5):755-768
British journal of cancer 2024 Mar;130(5):755-768
Biomimetic Nanoarchitectonics with Chitosan Nanogels for Collaborative Induction of Ferroptosis and Anticancer Immunity for Cancer Therapy.
Yang N, Pan X, Zhou X, Liu Z, Yang J, Zhang J, Jia Z, Shen Q
Advanced healthcare materials 2024 Mar;13(7):e2302752
Advanced healthcare materials 2024 Mar;13(7):e2302752
LuQi formula attenuates Cardiomyocyte ferroptosis via activating Nrf2/GPX4 signaling axis in heart failure.
Cheng P, Wang X, Liu Q, Yang T, Dai E, Sha W, Qu H, Zhou H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Mar;125:155357
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Mar;125:155357
VDR Activation Attenuates Renal Tubular Epithelial Cell Ferroptosis by Regulating Nrf2/HO-1 Signaling Pathway in Diabetic Nephropathy.
Wang H, Yu X, Liu D, Qiao Y, Huo J, Pan S, Zhou L, Wang R, Feng Q, Liu Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Mar;11(10):e2305563
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Mar;11(10):e2305563
Polyphyllin B inhibited STAT3/NCOA4 pathway and restored gut microbiota to ameliorate lung tissue injury in cigarette smoke-induced mice.
Wang Q, He Z, Zhu J, Hu M, Yang L, Yang H
BMC biotechnology 2024 Mar 8;24(1):13
BMC biotechnology 2024 Mar 8;24(1):13
NRF2 activation ameliorates blood-brain barrier injury after cerebral ischemic stroke by regulating ferroptosis and inflammation.
Fan W, Chen H, Li M, Fan X, Jiang F, Xu C, Wang Y, Wei W, Song J, Zhong D, Li G
Scientific reports 2024 Mar 4;14(1):5300
Scientific reports 2024 Mar 4;14(1):5300
Silent information regulator sirtuin 1 ameliorates acute liver failure via the p53/glutathione peroxidase 4/gasdermin D axis.
Zhou XN, Zhang Q, Peng H, Qin YJ, Liu YH, Wang L, Cheng ML, Luo XH, Li H
World journal of gastroenterology 2024 Mar 21;30(11):1588-1608
World journal of gastroenterology 2024 Mar 21;30(11):1588-1608
Mechanism of Dendrobium Nobile Polysaccharide Inhibition of Ferroptosis in Rats with Spinal Cord Injury.
Huang J, Luo J, Huang Y, Wang L, Zhu H, Li Z, Chen J
Journal of integrative neuroscience 2024 Mar 21;23(3):65
Journal of integrative neuroscience 2024 Mar 21;23(3):65
The E3 ligase TRIM7 suppresses the tumorigenesis of gastric cancer by targeting SLC7A11.
Chen Q, Zhang T, Zeng R, Zhang K, Li B, Zhu Z, Ma X, Zhang Y, Li L, Zhu J, Zhang G
Scientific reports 2024 Mar 20;14(1):6655
Scientific reports 2024 Mar 20;14(1):6655
TfR1 mediated iron metabolism dysfunction as a potential therapeutic target for osteoarthritis.
Wang W, Ma Z, Feng X, Ren J, Sun S, Shao Y, Zhang W, Yang X, Zhang J, Jing X
Arthritis research & therapy 2024 Mar 16;26(1):71
Arthritis research & therapy 2024 Mar 16;26(1):71
Tetrahydrobiopterin inhibitor-based antioxidant metabolic strategy for enhanced cancer ferroptosis-immunotherapy.
Liu Z, Kang R, Yang N, Pan X, Yang J, Yu H, Deng W, Jia Z, Zhang J, Shen Q
Journal of colloid and interface science 2024 Mar 15;658:100-113
Journal of colloid and interface science 2024 Mar 15;658:100-113
Cardiomyocyte-fibroblast interaction regulates ferroptosis and fibrosis after myocardial injury.
Mohr ME, Li S, Trouten AM, Stairley RA, Roddy PL, Liu C, Zhang M, Sucov HM, Tao G
iScience 2024 Mar 15;27(3):109219
iScience 2024 Mar 15;27(3):109219
Cyclin-dependent kinase inhibitor 1A inhibits pyroptosis to enhance human lung adenocarcinoma cell radioresistance by promoting DNA repair.
Li J, Liu T, Tang N, Lin S, Zhang F, Yuan W, Zhang T, Deng SH, Wu DM, Xu Y
Heliyon 2024 Mar 15;10(5):e26975
Heliyon 2024 Mar 15;10(5):e26975
SAP130 released by ferroptosis tubular epithelial cells promotes macrophage polarization via Mincle signaling in sepsis acute kidney injury.
Zhang J, Jiang J, Wang B, Wang Y, Qian Y, Suo J, Li Y, Peng Z
International immunopharmacology 2024 Mar 10;129:111564
International immunopharmacology 2024 Mar 10;129:111564
Glyphosate drives autophagy-dependent ferroptosis to inhibit testosterone synthesis in mouse Leydig cells.
Lu L, Lian CY, Lv YT, Zhang SH, Wang L, Wang L
The Science of the total environment 2024 Mar 1;914:169927
The Science of the total environment 2024 Mar 1;914:169927
Acupuncture alleviates CUMS-induced depression-like behaviors of rats by regulating oxidative stress, neuroinflammation and ferroptosis.
Shen J, Hao C, Yuan S, Chen W, Tong T, Chen Y, Shahzad Aslam M, Yan S, Li J, Zeng J, Liu S, Chen Y, Jiang Y, Li P, Meng X
Brain research 2024 Mar 1;1826:148715
Brain research 2024 Mar 1;1826:148715
Moderate mechanical stress suppresses chondrocyte ferroptosis in osteoarthritis by regulating NF-κB p65/GPX4 signaling pathway.
Han J, Zhan LN, Huang Y, Guo S, Zhou X, Kapilevich L, Wang Z, Ning K, Sun M, Zhang XA
Scientific reports 2024 Mar 1;14(1):5078
Scientific reports 2024 Mar 1;14(1):5078
Cell-Cycle-related Protein Centromere Protein F Deficiency Inhibits Cervical Cancer Cell Growth by Inducing Ferroptosis Via Nrf2 Inactivation.
Tang XH, Zhao TN, Guo L, Liu XY, Zhang WN, Zhang P
Cell biochemistry and biophysics 2024 Jun;82(2):997-1006
Cell biochemistry and biophysics 2024 Jun;82(2):997-1006
Changes of RNA m(6)A/m(5)C Modification Regulatory Molecules in Ferroptosis of T2DM Rat Pancreas.
Liu X, Wang N, Gu S, He Z
Cell biochemistry and biophysics 2024 Jun;82(2):1279-1289
Cell biochemistry and biophysics 2024 Jun;82(2):1279-1289
A Disintegrin and Metalloproteinase-8 Protects Against Erastin-Induced Neuronal Ferroptosis via Activating Nrf2/HO-1/FTH1 Signaling Pathway.
Qian Z, Zhang Q, Li P, Li Y, Zhang Y, Li R, Zhao T, Xia M, Chen Y, Hong X
Molecular neurobiology 2024 Jun;61(6):3490-3502
Molecular neurobiology 2024 Jun;61(6):3490-3502
Nicorandil Regulates Ferroptosis and Mitigates Septic Cardiomyopathy via TLR4/SLC7A11 Signaling Pathway.
Lu JS, Wang JH, Han K, Li N
Inflammation 2024 Jun;47(3):975-988
Inflammation 2024 Jun;47(3):975-988
Photodynamic therapy inhibits cancer progression and induces ferroptosis and apoptosis by targeting P53/GPX4/SLC7A11 signaling pathways in cholangiocarcinoma.
Yan X, Li Z, Chen H, Yang F, Tian Q, Zhang Y
Photodiagnosis and photodynamic therapy 2024 Jun;47:104104
Photodiagnosis and photodynamic therapy 2024 Jun;47:104104
YTHDF2 Promotes Cardiac Ferroptosis via Degradation of SLC7A11 in Cardiac Ischemia-Reperfusion Injury.
Pang P, Si W, Wu H, Ju J, Liu K, Wang C, Jia Y, Diao H, Zeng L, Jiang W, Yang Y, Xiong Y, Kong X, Zhang Z, Zhang F, Song J, Wang N, Yang B, Bian Y
Antioxidants & redox signaling 2024 Jun;40(16-18):889-905
Antioxidants & redox signaling 2024 Jun;40(16-18):889-905
Licochalcone A alleviates ferroptosis in doxorubicin-induced cardiotoxicity via the PI3K/AKT/MDM2/p53 pathway.
Chen G, Luo S, Guo H, Lin J, Xu S
Naunyn-Schmiedeberg's archives of pharmacology 2024 Jun;397(6):4247-4262
Naunyn-Schmiedeberg's archives of pharmacology 2024 Jun;397(6):4247-4262
Targeting NKAα1 to treat Parkinson's disease through inhibition of mitophagy-dependent ferroptosis.
Zhang X, Li G, Chen H, Nie XW, Bian JS
Free radical biology & medicine 2024 Jun;218:190-204
Free radical biology & medicine 2024 Jun;218:190-204
Downregulated GPX4 in salivary gland epithelial cells contributes to salivary secretion dysfunction in Sjogren's syndrome via lipid ROS/pSTAT4/AQP5 axis.
Zhou J, Pathak JL, Wu L, Chen B, Cao T, Wei W, Wu X, Chen G, Watanabe N, Li X, Li J
Free radical biology & medicine 2024 Jun;218:1-15
Free radical biology & medicine 2024 Jun;218:1-15
Cu(2)WS(4)-PEG Nanozyme as Multifunctional Sensitizers for Enhancing Immuno-Radiotherapy by Inducing Ferroptosis.
Fu S, Li Y, Shen L, Chen Y, Lu J, Ran Y, Zhao Y, Tang H, Tan L, Lin Q, Hao Y
Small (Weinheim an der Bergstrasse, Germany) 2024 Jun;20(26):e2309537
Small (Weinheim an der Bergstrasse, Germany) 2024 Jun;20(26):e2309537
Botulinum toxin A attenuates osteoarthritis development via inhibiting chondrocyte ferroptosis through SLC7Al1/GPX4 axis.
Zeng L, Liu Y, Wang Q, Wan H, Meng X, Tu P, Chen H, Luo A, Hu P, Ding X
Biochimica et biophysica acta. Molecular basis of disease 2024 Jun;1870(5):167215
Biochimica et biophysica acta. Molecular basis of disease 2024 Jun;1870(5):167215
Gut microbiota regulates the ALK5/NOX1 axis by altering glutamine metabolism to inhibit ferroptosis of intrahepatic cholangiocarcinoma cells.
Zhang Q, Zhou J, Zhai D, Jiang Q, Yang M, Zhou M
Biochimica et biophysica acta. Molecular basis of disease 2024 Jun;1870(5):167152
Biochimica et biophysica acta. Molecular basis of disease 2024 Jun;1870(5):167152
Stanniocalcin 2 Regulates Autophagy and Ferroptosis in Mammary Epithelial Cells of Dairy Cows Through the Mechanistic Target of Rapamycin Complex 1 Pathway.
Li R, Geng H, Tan X, Wang J, Deng L
The Journal of nutrition 2024 Jun;154(6):1790-1802
The Journal of nutrition 2024 Jun;154(6):1790-1802
MaiJiTong granule attenuates atherosclerosis by reducing ferroptosis via activating STAT6-mediated inhibition of DMT1 and SOCS1/p53 pathways in LDLR(-/-) mice.
Shi J, Yang MM, Yang S, Fan F, Zheng G, Miao Y, Hua Y, Zhang J, Cheng Y, Liu S, Guo Y, Guo L, Yang X, Fan G, Ma C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jun;128:155489
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jun;128:155489
Tau Aggregation-Dependent Lipid Peroxide Accumulation Driven by the hsa_circ_0001546/14-3-3/CAMK2D/Tau Complex Inhibits Epithelial Ovarian Cancer Peritoneal Metastasis.
Chai B, Wu Y, Yang H, Fan B, Cao S, Zhang X, Xie Y, Hu Z, Ma Z, Zhang Y, Pan W, Meng W, Meng J, Tian W, Zhang J, Li Y, Shao Y, Wang S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jun;11(23):e2310134
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jun;11(23):e2310134
N6022 attenuates cerebral ischemia/reperfusion injury-induced microglia ferroptosis by promoting Nrf2 nuclear translocation and inhibiting the GSNOR/GSTP1 axis.
Duan WL, Ma YP, Wang XJ, Ma CS, Han B, Sheng ZM, Dong H, Zhang LY, Li PA, Zhang BG, He MT
European journal of pharmacology 2024 Jun 5;972:176553
European journal of pharmacology 2024 Jun 5;972:176553
Remote Ischemic Postconditioning-Mediated Neuroprotection against Stroke by Promoting Ketone Body-Induced Ferroptosis Inhibition.
Huang LY, Zhang YD, Liu YN, Liang ZY, Chen J, Wang B, Yin QL, Wang PP, Wang W, Qi SH
ACS chemical neuroscience 2024 Jun 5;15(11):2223-2232
ACS chemical neuroscience 2024 Jun 5;15(11):2223-2232
Bioactive compound schaftoside from Clinacanthus nutans attenuates acute liver injury by inhibiting ferroptosis through activation the Nrf2/GPX4 pathway.
Yu Y, Liang J, Yuan Z, Wang A, Liu X, Chen Y, Zhang M, Gao Y, Zhang H, Liu Y
Journal of ethnopharmacology 2024 Jun 28;328:118135
Journal of ethnopharmacology 2024 Jun 28;328:118135
Exploration and Validation of Ferroptosis-Associated Genes in ADAR1 Deletion-Induced NAFLD through RNA-seq Analysis.
Yin X, Mi Y, Wang X, Li Y, Zhu X, Bukhari I, Wang Q, Zheng P, Xue X, Tang Y
International immunopharmacology 2024 Jun 15;134:112177
International immunopharmacology 2024 Jun 15;134:112177
ROS-responsive MSC-derived Exosome Mimetics Carrying MHY1485 Alleviate Renal Ischemia Reperfusion Injury through Multiple Mechanisms.
Qian Z, Zhang X, Huang J, Niu X, Zhu C, Tai Z, Zhu Q, Chen Z, Zhu T, Wu G
ACS omega 2024 Jun 11;9(23):24853-24863
ACS omega 2024 Jun 11;9(23):24853-24863
ERRFI1 exacerbates hepatic ischemia reperfusion injury by promoting hepatocyte apoptosis and ferroptosis in a GRB2-dependent manner.
Zhao H, Mao H
Molecular medicine (Cambridge, Mass.) 2024 Jun 11;30(1):82
Molecular medicine (Cambridge, Mass.) 2024 Jun 11;30(1):82
Rack1-mediated ferroptosis affects hindgut development in rats with anorectal malformations: Spatial transcriptome insights.
Wang CY, Li MY, Li SY, Wei XG, Dong NX, Liu ST, Yuan ZW, Li B, Pierro A, Tang XB, Bai YZ
Cell proliferation 2024 Jul;57(7):e13618
Cell proliferation 2024 Jul;57(7):e13618
Sleeve gastrectomy links the attenuation of diabetic kidney disease to the inhibition of renal tubular ferroptosis through down-regulating TGF-β1/Smad3 signaling pathway.
Liu C, Zhong M, Jin X, Zhu J, Cheng Y, Li L, Xu Q, Liu Q, Ding H, Zhang G
Journal of endocrinological investigation 2024 Jul;47(7):1763-1776
Journal of endocrinological investigation 2024 Jul;47(7):1763-1776
GPX7 reduces chondrocyte inflammation and extracellular matrix degradation triggered by IL‑1β, via a mechanism mediated by ferroptosis.
Chen B, Fu W, Jie C, Zhang G, Li Z, Liu Y, Zhou S
Molecular medicine reports 2024 Jul;30(1)
Molecular medicine reports 2024 Jul;30(1)
Dihydroartemisinin induces ferroptosis in T cell acute lymphoblastic leukemia cells by downregulating SLC7A11 and activating the ATF4‑CHOP signaling pathway.
Tang N, Liu X, Liu Y, Wang H, Zhao Y, Wang H, Hu Z
Oncology letters 2024 Jul;28(1):337
Oncology letters 2024 Jul;28(1):337
Berberine synergises with ferroptosis inducer sensitizing NSCLC to ferroptosis in p53-dependent SLC7A11-GPX4 pathway.
Liao W, Zhang R, Chen G, Zhu X, Wu W, Chen Z, Jiang C, Lin Z, Ma L, Yu H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jul;176:116832
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jul;176:116832
Baicalin promotes the sensitivity of NSCLC to cisplatin by regulating ferritinophagy and macrophage immunity through the KEAP1-NRF2/HO-1 pathway.
Chen Y, Bao S, Wang Z, Fang Z, Tang H
European journal of medical research 2024 Jul 26;29(1):387
European journal of medical research 2024 Jul 26;29(1):387
Leonurine Ameliorates Diabetic Nephropathy through GPX4-Mediated Ferroptosis of Endothelial Cells.
Yu X, Li Y, Zhang Y, Yin K, Chen X, Zhu X
Frontiers in bioscience (Landmark edition) 2024 Jul 25;29(7):270
Frontiers in bioscience (Landmark edition) 2024 Jul 25;29(7):270
Quercetin inhibits neuronal Ferroptosis and promotes immune response by targeting lipid metabolism-related gene PTGS2 to alleviate breast cancer-related depression.
Zhu Q, Han Y, He Y, Meng P, Fu Y, Yang H, He G, Long M, Shi Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155560
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155560
Overexpression of transcription factor TBX5 inhibits the activation of YAP1-TEAD1 pathway to promote ferroptosis in lung cancer cells.
Ma R, Hu K, Dai S, Wang Y
Biochemical and biophysical research communications 2024 Jul 23;718:150037
Biochemical and biophysical research communications 2024 Jul 23;718:150037
Hesperetin Alleviated Experimental Colitis via Regulating Ferroptosis and Gut Microbiota.
Wang J, Yao Y, Yao T, Shi Q, Zeng Y, Li L
Nutrients 2024 Jul 19;16(14)
Nutrients 2024 Jul 19;16(14)
Mitochondrial miR-12294-5p-Regulated Copper Exposure-Caused Mitochondrial-Dependent Ferroptosis by Targeted Inhibition of CISD1 in Chicken Hepatocytes.
Zhong G, Wang M, Sun B, Ma F, Yu W, Hu L, Liao J, Tang Z
Journal of agricultural and food chemistry 2024 Jul 17;72(28):15948-15958
Journal of agricultural and food chemistry 2024 Jul 17;72(28):15948-15958
Ultrasound-responsive Bi(2)MoO(6)-MXene heterojunction as ferroptosis inducers for stimulating immunogenic cell death against ovarian cancer.
Cheng S, Zhou T, Luo Y, Zhang J, Dong K, Zhang Q, Shu W, Zhang T, Zhang Q, Shi R, Yao Y, Wang H
Journal of nanobiotechnology 2024 Jul 11;22(1):408
Journal of nanobiotechnology 2024 Jul 11;22(1):408
Ferroptosis: First evidence in premature duck ovary induced by polyvinyl chloride microplastics.
Ali W, Chen Y, Shah MG, Buriro RS, Sun J, Liu Z, Zou H
The Science of the total environment 2024 Jul 10;933:173032
The Science of the total environment 2024 Jul 10;933:173032
An investigation of the distributions of ferroptosis and necroptosis mediators in the maternal-fetal interface at different days of rat pregnancy.
Tatar M, Tüfekci KK
Anatomia, histologia, embryologia 2024 Jan;53(1):e12991
Anatomia, histologia, embryologia 2024 Jan;53(1):e12991
Berberine alleviates contrast-induced nephropathy by activating Akt/Foxo3a/Nrf2 signalling pathway.
Wang W, Yu R, Wu C, Li Q, Chen J, Xiao Y, Chen H, Song J, Ji M, Zuo Z
Journal of cellular and molecular medicine 2024 Jan;28(1):e18016
Journal of cellular and molecular medicine 2024 Jan;28(1):e18016
Ambra1 in exosomes secreted by HK-2 cells damaged by supersaturated oxalate induce mitophagy and autophagy-ferroptosis in normal HK-2 cells to participate in the occurrence of kidney stones.
Su X, Song C, He Z, Song Q, Meng L, Dong C, Zhou J, Ke H, Xiong Y, Liu J, Liao W, Yang S
Biochimica et biophysica acta. Molecular cell research 2024 Jan;1871(1):119604
Biochimica et biophysica acta. Molecular cell research 2024 Jan;1871(1):119604
KLF6 silencing attenuates MCAO-induced brain injury and cognitive dysfunction via targeting ferroptosis and activating the Nrf2/HO-1 pathway.
Qian H, Zhou S, Qian R, Li Q, Zhang J, Ding Y, Wang C
Human & experimental toxicology 2024 Jan-Dec;43:9603271241304372
Human & experimental toxicology 2024 Jan-Dec;43:9603271241304372
Cadmium Induces Kidney Iron Deficiency and Chronic Kidney Injury by Interfering with the Iron Metabolism in Rats.
Zhang K, Long M, Dong W, Li J, Wang X, Liu W, Huang Q, Ping Y, Zou H, Song R, Liu G, Ran D, Liu Z
International journal of molecular sciences 2024 Jan 7;25(2)
International journal of molecular sciences 2024 Jan 7;25(2)
Targeting PKD2 aggravates ferritinophagy-mediated ferroptosis via promoting autophagosome-lysosome fusion and enhances efficacy of carboplatin in lung adenocarcinoma.
Liu Y, Pang Z, Wang Y, Liu J, Wang G, Du J
Chemico-biological interactions 2024 Jan 5;387:110794
Chemico-biological interactions 2024 Jan 5;387:110794
Buddlejasaponin IVb ameliorates ferroptosis of dopaminergic neuron by suppressing IRP2-mediated iron overload in Parkinson's disease.
Li QM, Xu T, Zha XQ, Feng XW, Zhang FY, Luo JP
Journal of ethnopharmacology 2024 Jan 30;319(Pt 1):117196
Journal of ethnopharmacology 2024 Jan 30;319(Pt 1):117196
Multifunctional Fe-based coordination polymer nano-bomb modified with β-lapachone and CaO(2) for targeted tumor dual chemodynamic therapy with enhanced ferroptosis and H(2)O(2) self-supply.
Zhao P, Gong L, Chang L, Du H, Geng M, Meng S, Dai L
Journal of nanobiotechnology 2024 Jan 3;22(1):3
Journal of nanobiotechnology 2024 Jan 3;22(1):3
AURKA inhibition induces Ewing's sarcoma apoptosis and ferroptosis through NPM1/YAP1 axis.
Chen H, Hu J, Xiong X, Chen H, Lin B, Chen Y, Li Y, Cheng D, Li Z
Cell death & disease 2024 Jan 29;15(1):99
Cell death & disease 2024 Jan 29;15(1):99
Sunitinib induces cardiotoxicity through modulating oxidative stress and Nrf2-dependent ferroptosis in vitro and in vivo.
Li D, Song C, Song C, Tian X, Zhang H, Zhang J, Zhao X
Chemico-biological interactions 2024 Jan 25;388:110829
Chemico-biological interactions 2024 Jan 25;388:110829
Bomidin attenuates inflammation of periodontal ligament stem cells and periodontitis in mice via inhibiting ferroptosis.
Wu W, Li G, Dong S, Huihan Chu C, Ma S, Zhang Z, Yuan S, Wu J, Guo Z, Shen Y, Wang J, Tang C
International immunopharmacology 2024 Jan 25;127:111423
International immunopharmacology 2024 Jan 25;127:111423
High-Throughput Sequencing to Investigate the Expression and Potential Role of Differentially Expressed microRNAs in Myocardial Cells after Ischemia-Reperfusion Injury.
Li S, Lv D, Lu Y, Zhang Y, Jia Y
Frontiers in bioscience (Landmark edition) 2024 Jan 23;29(1):38
Frontiers in bioscience (Landmark edition) 2024 Jan 23;29(1):38
α-Ketoglutarate improves cardiac insufficiency through NAD(+)-SIRT1 signaling-mediated mitophagy and ferroptosis in pressure overload-induced mice.
Yu H, Gan D, Luo Z, Yang Q, An D, Zhang H, Hu Y, Ma Z, Zeng Q, Xu D, Ren H
Molecular medicine (Cambridge, Mass.) 2024 Jan 22;30(1):15
Molecular medicine (Cambridge, Mass.) 2024 Jan 22;30(1):15
Rapid and comprehensive metabolites identification of 5-demethylnobiletin in rats using UPLC/Triple-TOF-MS/MS based on multiple mass defect filter and their neuroprotection against ferroptosis.
Yuan S, Gao P, Wu S, Liang X, Xiao Y, Tu P, Jiang Y
Journal of pharmaceutical and biomedical analysis 2024 Jan 20;238:115842
Journal of pharmaceutical and biomedical analysis 2024 Jan 20;238:115842
PKCiota Inhibits the Ferroptosis of Esophageal Cancer Cells via Suppressing USP14-Mediated Autophagic Degradation of GPX4.
Tao H, Song SJ, Fan ZW, Li WT, Jin X, Jiang W, Bai J, Shi ZZ
Antioxidants (Basel, Switzerland) 2024 Jan 17;13(1)
Antioxidants (Basel, Switzerland) 2024 Jan 17;13(1)
Hepatic Alterations in a BTBR T + Itpr3tf/J Mouse Model of Autism and Improvement Using Melatonin via Mitigation Oxidative Stress, Inflammation and Ferroptosis.
Rezzani R, Gianò M, Pinto D, Rinaldi F, van Noorden CJF, Favero G
International journal of molecular sciences 2024 Jan 16;25(2)
International journal of molecular sciences 2024 Jan 16;25(2)
Heliox Protects SH-SY5Y Cells from Oxygen-Glucose Deprivation/Reperfusion-Induced Ferroptosis.
Yu S, Xiong W, Xu W, Chen Y
Journal of integrative neuroscience 2024 Jan 16;23(1):14
Journal of integrative neuroscience 2024 Jan 16;23(1):14
Resveratrol protected against the development of endometriosis by promoting ferroptosis through miR-21-3p/p53/SLC7A11 signaling pathway.
Zou W, Wang X, Xia X, Zhang T, Nie M, Xiong J, Fang X
Biochemical and biophysical research communications 2024 Jan 15;692:149338
Biochemical and biophysical research communications 2024 Jan 15;692:149338
Hesperetin promotes bladder cancer cells death via the PI3K/AKT pathway by network pharmacology and molecular docking.
Lv Y, Liu Z, Deng L, Xia S, Mu Q, Xiao B, Xiu Y, Liu Z
Scientific reports 2024 Jan 10;14(1):1009
Scientific reports 2024 Jan 10;14(1):1009
Excessive SOX8 reprograms energy and iron metabolism to prime hepatocellular carcinoma for ferroptosis.
Yang X, Gu C, Cai J, Li F, He X, Luo L, Xiao W, Hu B, Hu J, Qian H, Ren S, Zhang L, Zhu X, Yang L, Yang J, Yang Z, Zheng Y, Huang X, Wang Z
Redox biology 2024 Feb;69:103002
Redox biology 2024 Feb;69:103002
Targeting Ferroptosis Promotes Functional Recovery by Mitigating White Matter Injury Following Acute Carbon Monoxide Poisoning.
Wang S, Xiong B, Tian Y, Hu Q, Jiang X, Zhang J, Chen L, Wang R, Li M, Zhou X, Zhang T, Ge H, Yu A
Molecular neurobiology 2024 Feb;61(2):1157-1174
Molecular neurobiology 2024 Feb;61(2):1157-1174
Integrated analysis and validation of TRIM23/p53 signaling pathway in hepatic stellate cells ferroptosis and liver fibrosis.
Chen J, Zhang R, Li F, Lin S, Wang J
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2024 Feb;56(2):281-290
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2024 Feb;56(2):281-290
Nrf2 protects against cartilage endplate degeneration through inhibiting NCOA4‑mediated ferritinophagy.
Ma Z, Lu H, Feng X, Du T, Li J, Zhang Q, Gu X, Shao Y, Jing X, Su C
International journal of molecular medicine 2024 Feb;53(2)
International journal of molecular medicine 2024 Feb;53(2)
SENP1 inhibits ferroptosis and promotes head and neck squamous cell carcinoma by regulating ACSL4 protein stability via SUMO1.
Xu X, Mao Y, Feng Z, Dai F, Gu T, Zheng J
Oncology reports 2024 Feb;51(2)
Oncology reports 2024 Feb;51(2)
Protective effects of melatonin on DEHP-induced apoptosis and oxidative stress in prepubertal testes via the PI3K/AKT pathway.
Chen J, Zhao T, Zheng X, Kang L, Wang J, Wei Y, Wu Y, Shen L, Long C, Wei G, Wu S
Environmental toxicology 2024 Feb;39(2):952-964
Environmental toxicology 2024 Feb;39(2):952-964
Se-(Methyl)-selenocysteine ameliorates blood-brain barrier disruption of focal cerebral ischemia mice via ferroptosis inhibition and tight junction upregulation in an Akt/GSK3β-dependent manner.
Fei Y, Li T, Wu R, Xu X, Hu S, Yang Y, Jin C, Tang W, Zhang X, Du Q, Liu C
Psychopharmacology 2024 Feb;241(2):379-399
Psychopharmacology 2024 Feb;241(2):379-399
Fructus Ligustri Lucidi inhibits ferroptosis in ovariectomy‑induced osteoporosis in rats via the Nrf2/HO‑1 signaling pathway.
Li P, Wang Y, Yan Q, Yang Y, Zhu R, Ma J, Chen Y, Liu H, Zhang Z
Biomedical reports 2024 Feb;20(2):27
Biomedical reports 2024 Feb;20(2):27
WWP2 protects against sepsis-induced cardiac injury through inhibiting cardiomyocyte ferroptosis.
Li Z, Wu B, Chen J, Ye N, Ma R, Song C, Sun Y, Zhang X, Sun G
Journal of translational internal medicine 2024 Feb;12(1):35-50
Journal of translational internal medicine 2024 Feb;12(1):35-50
Bile acids inhibit ferroptosis sensitivity through activating farnesoid X receptor in gastric cancer cells.
Liu CX, Gao Y, Xu XF, Jin X, Zhang Y, Xu Q, Ding HX, Li BJ, Du FK, Li LC, Zhong MW, Zhu JK, Zhang GY
World journal of gastroenterology 2024 Feb 7;30(5):485-498
World journal of gastroenterology 2024 Feb 7;30(5):485-498
Inhibiting LCN2 can suppress the development of NSCLC by promoting ferroptosis.
Pan Z, Li B, Lu P, Rong G, Wang X
Gene 2024 Feb 5;894:148026
Gene 2024 Feb 5;894:148026
SMG9 is a novel prognostic-related biomarker in glioma correlating with ferroptosis and immune infiltrates.
Dai Y, Zhang H, Feng S, Guo C, Tian W, Sun Y, Zhang Y
Heliyon 2024 Feb 29;10(4):e25716
Heliyon 2024 Feb 29;10(4):e25716
SKP alleviates the ferroptosis in diabetic kidney disease through suppression of HIF-1α/HO-1 pathway based on network pharmacology analysis and experimental validation.
Yan Y, Yuan N, Chen Y, Ma Y, Chen A, Wang F, Yan S, He Z, He J, Zhang C, Wang H, Wang M, Diao J, Xiao W
Chinese medicine 2024 Feb 25;19(1):31
Chinese medicine 2024 Feb 25;19(1):31
Inhibition of ferroptosis reverses heart failure with preserved ejection fraction in mice.
Xiong Y, Liu X, Jiang L, Hao T, Wang Y, Li T
Journal of translational medicine 2024 Feb 24;22(1):199
Journal of translational medicine 2024 Feb 24;22(1):199
Complement components regulates ferroptosis in CVB3 viral myocarditis by interatction with TFRC.
Yi L, Yang Y, Hu Y, Wu Z, Kong M, Zuoyuan B, Xin X, Yang Z
Free radical biology & medicine 2024 Feb 20;212:349-359
Free radical biology & medicine 2024 Feb 20;212:349-359
P21 resists ferroptosis in osteoarthritic chondrocytes by regulating GPX4 protein stability.
Zheng Z, Shang X, Sun K, Hou Y, Zhang X, Xu J, Liu H, Ruan Z, Hou L, Guo Z, Wang G, Xu F, Guo F
Free radical biology & medicine 2024 Feb 20;212:336-348
Free radical biology & medicine 2024 Feb 20;212:336-348
Pterostilbene attenuates heart failure by inhibiting myocardial ferroptosis through SIRT1/GSK-3β/GPX4 signaling pathway.
Zhang F, Zeng Z, Zhang J, Li X, Yang W, Wei Y, Guo X
Heliyon 2024 Feb 15;10(3):e24562
Heliyon 2024 Feb 15;10(3):e24562
Oridonin-induced ferroptosis and apoptosis: a dual approach to suppress the growth of osteosarcoma cells.
Zhang F, Hao Y, Yang N, Liu M, Luo Y, Zhang Y, Zhou J, Liu H, Li J
BMC cancer 2024 Feb 12;24(1):198
BMC cancer 2024 Feb 12;24(1):198
1,4-dihydroxy quininib activates ferroptosis pathways in metastatic uveal melanoma and reveals a novel prognostic biomarker signature.
Tonelotto V, Costa-Garcia M, O'Reilly E, Smith KF, Slater K, Dillon ET, Pendino M, Higgins C, Sist P, Bosch R, Passamonti S, Piulats JM, Villanueva A, Tramer F, Vanella L, Carey M, Kennedy BN
Cell death discovery 2024 Feb 10;10(1):70
Cell death discovery 2024 Feb 10;10(1):70
NCF-1 plays a pivotal role in the survival of adenocarcinoma cells of pancreatic and gastric origins.
Furuya-Ikude C, Kitta A, Tomonobu N, Kawasaki Y, Sakaguchi M, Kondo E
In vitro cellular & developmental biology. Animal 2024 Dec;60(10):1151-1159
In vitro cellular & developmental biology. Animal 2024 Dec;60(10):1151-1159
Apelin deficiency exacerbates cardiac injury following infarction by accelerating cardiomyocyte ferroptosis.
Zhao Y, Liang X, Li T, Shao Z, Cao Z, Zeng Y, Yan X, Chen Q, Zhou H, Li W, Cheng G, Jiang Y, Li X, Zhang Y, Hu B
Free radical research 2024 Dec;58(12):854-867
Free radical research 2024 Dec;58(12):854-867
Inhibition of CDGSH iron‑sulfur domain 2 exhibits tumor-suppressing effects on diffuse large B-cell lymphoma (DLBCL) by inducing ferroptosis through the regulation of the NRF2/SLC7A11/GPX4 pathway.
Zhang J, Wang T, Zhang H, Li N, Liu B, Fang L
Toxicology and applied pharmacology 2024 Dec;493:117148
Toxicology and applied pharmacology 2024 Dec;493:117148
Sirt6 overexpression relieves ferroptosis and delays the progression of diabetic nephropathy via Nrf2/GPX4 pathway.
Du L, Guo C, Zeng S, Yu K, Liu M, Li Y
Renal failure 2024 Dec;46(2):2377785
Renal failure 2024 Dec;46(2):2377785
Identification and validation of protein biomarkers for predicting gastrointestinal stromal tumor recurrence.
Sun J, Li J, He Y, Kang W, Ye X
Computational and structural biotechnology journal 2024 Dec;23:1065-1075
Computational and structural biotechnology journal 2024 Dec;23:1065-1075
The plant extract PNS mitigates atherosclerosis via promoting Nrf2-mediated inhibition of ferroptosis through reducing USP2-mediated Keap1 deubiquitination.
Zhao Y, Zheng G, Yang S, Liu S, Wu Y, Miao Y, Liang Z, Hua Y, Zhang J, Shi J, Li D, Cheng Y, Zhang Y, Chen Y, Fan G, Ma C
British journal of pharmacology 2024 Dec;181(23):4822-4844
British journal of pharmacology 2024 Dec;181(23):4822-4844
Yanghe Decoction promotes ferroptosis through PPARγ-dependent autophagy to inhibit the malignant progression of triple-negative breast cancer.
Cheng Y, Yu G, Du C, Chen Z, Liu X
Prostaglandins & other lipid mediators 2024 Dec;175:106909
Prostaglandins & other lipid mediators 2024 Dec;175:106909
Y9, a Gboxin analog, displays anti-tumor effect in non-small cell lung cancer by inducing lysosomal dysfunction and apoptosis.
Yin J, Ding L, Yao S, Huang J, Xiao Y, Wang Y, Zhang B, Rehmutulla M, Gu L, Tong Q, Zhang Y
Bioorganic chemistry 2024 Dec;153:107820
Bioorganic chemistry 2024 Dec;153:107820
Ginsenoside compound K alleviates brain aging by inhibiting ferroptosis through modulation of the ASK1-MKK7-JNK signaling pathway.
Yan X, Bai X, Sun G, Duan Z, Fu R, Zeng W, Zhu C, Fan D
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156239
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156239
Naringenin alleviates intestinal ischemia/reperfusion injury by inhibiting ferroptosis via targeting YAP/STAT3 signaling axis.
Hou M, Li X, Chen F, Tan Z, Han X, Liu J, Zhou J, Shi Y, Zhang J, Lv J, Leng Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156095
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156095
The Intestinal Transporter SLC30A1 Plays a Critical Role in Regulating Systemic Zinc Homeostasis.
Sun S, Xie E, Xu S, Ji S, Wang S, Shen J, Wang R, Shen X, Su Y, Song Z, Wu X, Zhou J, Cai Z, Li X, Zhang Y, Min J, Wang F
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Dec;11(46):e2406421
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Dec;11(46):e2406421
Effects of high-dose selenium-enriched Saccharomyces cerevisiae on growth performance, antioxidant status, tissue fat content and selenium concentration, and selenoenzyme mRNA expression in chicks.
Gao S, Qiu H, Chen F, Yang G, Hou L, Dong J, Dong W
Poultry science 2024 Dec;103(12):104312
Poultry science 2024 Dec;103(12):104312
To explore the protective mechanism of promethazine against hippocampal neuron injury based on network pharmacology and experimental verification.
Bai L, Li F
Medicine 2024 Dec 6;103(49):e40550
Medicine 2024 Dec 6;103(49):e40550
Gypenoside A-loaded mPEG-PLGA nanoparticles ameliorate high-glucose-induced retinal microvasculopathy by inhibiting ferroptosis.
Chen Q, Qiu FS, Xie W, Yu WY, Su ZA, Qin GM, Kang YK, Jiang SL, Yu CH
International journal of pharmaceutics 2024 Dec 5;666:124758
International journal of pharmaceutics 2024 Dec 5;666:124758
RTA408 alleviates lipopolysaccharide-induced acute lung injury via inhibiting Bach1-mediated ferroptosis.
Wu Y, Zhang Y, Ge L, He S, Zhang Y, Chen D, Nie Y, Zhu M, Pang Q
International immunopharmacology 2024 Dec 5;142(Pt B):113250
International immunopharmacology 2024 Dec 5;142(Pt B):113250
Simvastatin induces ferroptosis and activates anti-tumor immunity to sensitize anti-PD-1 immunotherapy in microsatellite stable gastric cancer.
Ning Y, Fang S, Zhang R, Fang J, Lin K, Ding Y, Nie H, Zhou J, Zhao Q, Ke H, Wang H, Wang F
International immunopharmacology 2024 Dec 5;142(Pt B):113244
International immunopharmacology 2024 Dec 5;142(Pt B):113244
OTULIN confers cisplatin resistance in osteosarcoma by mediating GPX4 protein homeostasis to evade the mitochondrial apoptotic pathway.
Zheng Z, Zeng Y, Bao X, Huang C, Guo F, Xu F, Luo Z
Journal of experimental & clinical cancer research : CR 2024 Dec 26;43(1):330
Journal of experimental & clinical cancer research : CR 2024 Dec 26;43(1):330
Apigenin alleviates Sjögren's syndrome-induced salivary gland epithelial cell ferroptosis via ERα signaling-mediated regulation of the ATF3/SLC7A1l axis.
Liu Q, Mao T, Liu F, Chen B, Liu Z, Pathak JL, Li J
International immunopharmacology 2024 Dec 25;143(Pt 2):113409
International immunopharmacology 2024 Dec 25;143(Pt 2):113409
ASIC1a regulates ferroptosis in hepatic stellate cells via the Hippo/Yap-1 pathway in liver fibrosis.
Zhu Y, Cao C, Li Z, Xu Z, Qian S, Zhang J, Li M, Hu X, Zhang A, Du N, Pan X, Wang X, Sun Y, Wang J, Huang Y
International immunopharmacology 2024 Dec 25;143(Pt 1):113226
International immunopharmacology 2024 Dec 25;143(Pt 1):113226
African swine fever virus enhances viral replication by increasing intracellular reduced glutathione levels, which suppresses stress granule formation.
Gao H, Gu T, Gao X, Song Z, Liu J, Song Y, Zhang G, Sun Y
Veterinary research 2024 Dec 20;55(1):172
Veterinary research 2024 Dec 20;55(1):172
DNMT aberration-incurred GPX4 suppression prompts osteoblast ferroptosis and osteoporosis.
Ruan B, Dong J, Wei F, Huang Z, Yang B, Zhang L, Li C, Dong H, Cao W, Wang H, Wang Y
Bone research 2024 Dec 2;12(1):68
Bone research 2024 Dec 2;12(1):68
Chemerin attenuates acute kidney injury by inhibiting ferroptosis via the AMPK/NRF2/SLC7A11 axis.
Ma Y, Fei S, Chen X, Gui Y, Zhou B, Xiang T, Liu J, Yue K, Li Q, Jiang W, Sun C, Huang X
Communications biology 2024 Dec 19;7(1):1679
Communications biology 2024 Dec 19;7(1):1679
Integrated network pharmacology and transcriptomics to explore the mechanism of compound Dihuang granule (CDG) protects dopaminergic neurons by regulating the Nrf2/HMOX1 pathway in the 6-OHDA/MPP(+)-induced model of Parkinson's disease.
Sun X, Yang S, He Z, Wang L, He J
Chinese medicine 2024 Dec 18;19(1):170
Chinese medicine 2024 Dec 18;19(1):170
FAM96B negatively regulates FOSL1 to modulate the osteogenic differentiation and regeneration of periodontal ligament stem cells via ferroptosis.
Qin Q, Yang H, Guo R, Zheng Y, Huang Y, Jin L, Fan Z, Li W
Stem cell research & therapy 2024 Dec 18;15(1):471
Stem cell research & therapy 2024 Dec 18;15(1):471
IL-1β-induced mesenchymal stem cell-derived exosomes inhibit neuronal ferroptosis in intracerebral hemorrhage through the HSPA5/GPX4 axis.
Li J, Lin L, Yu Z, He J, Li Y, Jiang J, Xia Y
Brain research 2024 Dec 15;1845:149219
Brain research 2024 Dec 15;1845:149219
Effects of ginger root extract on cognitive impairment and the Nrf2/GPX4/SLC7A11 signaling pathway in aluminum-exposed rats.
Qin L, Jiang X, Wei Y, Xie J, Yang L
Metabolic brain disease 2024 Dec 11;40(1):60
Metabolic brain disease 2024 Dec 11;40(1):60
Ion channel Piezo1 induces ferroptosis of trabecular meshwork cells: a novel observation in the pathogenesis in primary open angle glaucoma.
Liu K, Xu J, Yang R, Wang F, Su Y
American journal of physiology. Cell physiology 2024 Dec 1;327(6):C1591-C1603
American journal of physiology. Cell physiology 2024 Dec 1;327(6):C1591-C1603
Pharmacodynamic insights into maresin 1: Enhancing flap viability via the keap1/Nrf2 axis to control ROS-driven apoptosis and ferroptosis.
Fang P, Cheng S, Lai Y, Ma X, Lu K, Lu J, Li G, Yang E, Yang N, Gao W, Jiang R
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2024 Dec 1;203:106923
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2024 Dec 1;203:106923
A polo-like kinase 1 inhibitor enhances erastin sensitivity in head and neck squamous cell carcinoma cells in vitro.
Wu X, Wu J
Cancer chemotherapy and pharmacology 2024 Aug;94(2):183-195
Cancer chemotherapy and pharmacology 2024 Aug;94(2):183-195
Ferroptosis is involved in cisplatin sensitivity of the S3 segment of immortalized proximal tubule cells.
Taguchi H, Sumi D, Himeno S, Fujishiro H
Toxicology 2024 Aug;506:153840
Toxicology 2024 Aug;506:153840
Propofol Mitigates Sepsis-Induced Brain Injury by Inhibiting Ferroptosis Via Activation of the Nrf2/HO-1axis.
Zhou Y, Yang Y, Yi L, Pan M, Tang W, Duan H
Neurochemical research 2024 Aug;49(8):2131-2147
Neurochemical research 2024 Aug;49(8):2131-2147
GOLPH3 inhibits erastin-induced ferroptosis in colorectal cancer cells.
Chen L, Wang C, Chen X, Wu Y, Chen M, Deng X, Qiu C
Cell biology international 2024 Aug;48(8):1198-1211
Cell biology international 2024 Aug;48(8):1198-1211
Isobavachalcone induces hepatotoxicity in zebrafish embryos and HepG2 cells via the System Xc(-)-GSH-GPX4 signaling pathway in ferroptosis response.
Ni X, Gao C, Zhu X, Zhang X, Fang Y, Hao Z
Journal of applied toxicology : JAT 2024 Aug;44(8):1139-1152
Journal of applied toxicology : JAT 2024 Aug;44(8):1139-1152
Curcumin suppresses colorectal cancer by induction of ferroptosis via regulation of p53 and solute carrier family 7 member 11/glutathione/glutathione peroxidase 4 signaling axis.
Ming T, Lei J, Peng Y, Wang M, Liang Y, Tang S, Tao Q, Wang M, Tang X, He Z, Liu X, Xu H
Phytotherapy research : PTR 2024 Aug;38(8):3954-3972
Phytotherapy research : PTR 2024 Aug;38(8):3954-3972
PRDX6 augments selenium utilization to limit iron toxicity and ferroptosis.
Fujita H, Tanaka YK, Ogata S, Suzuki N, Kuno S, Barayeu U, Akaike T, Ogra Y, Iwai K
Nature structural & molecular biology 2024 Aug;31(8):1277-1285
Nature structural & molecular biology 2024 Aug;31(8):1277-1285
Baicalin protects against hepatocyte injury caused by aflatoxin B(1) via the TP53-related ferroptosis Pathway.
Zhang HJ, Luo JZ, Lan CL, Teng X, Ge B, Liu JQ, Xie HX, Yang KJ, Qin CJ, Zhou X, Peng T
Ecotoxicology and environmental safety 2024 Aug;281:116661
Ecotoxicology and environmental safety 2024 Aug;281:116661
Casticin induces ferroptosis in human osteosarcoma cells through Fe(2+) overload and ROS production mediated by HMOX1 and LC3-NCOA4.
Jiwa H, Xie Z, Qu X, Xu J, Huang Y, Huang X, Zhang J, Wang N, Li N, Luo J, Luo X
Biochemical pharmacology 2024 Aug;226:116346
Biochemical pharmacology 2024 Aug;226:116346
The Deubiquitinase USP22-Stabilized COL17A1 Promotes Lung Adenocarcinoma Progression.
Chen G, Du D, Wang H, Li H
The clinical respiratory journal 2024 Aug;18(8):e13824
The clinical respiratory journal 2024 Aug;18(8):e13824
Integrated multi-omics profiling landscape of organising pneumonia.
Tang Y, Chu C, Bu S, Sun Q, Liu A, Xie J, Qiao S, Huang L, Wang H
Clinical and translational medicine 2024 Aug;14(8):e1782
Clinical and translational medicine 2024 Aug;14(8):e1782
Exosomes From Muscle-Derived Stem Cells Repair Peripheral Nerve Injury by Inhibiting Ferroptosis via the Keap1-Nrf2-Ho-1 Axis.
Liu Z, Zeng X, Bian W, Li H, Tegeleqi B, Gao Z, Liu J
Journal of cellular biochemistry 2024 Aug;125(8):e30614
Journal of cellular biochemistry 2024 Aug;125(8):e30614
The effects of the atrial natriuretic peptide deficiency on renal cortical mitochondrial bioenergetics in the Dahl SS rat.
Cherezova A, Sudarikova A, Vasileva V, Iurchenko R, Nikiforova A, Spires DR, Zamaro AS, Jones AC, Schibalski RS, Dong Z, Palygin O, Stadler K, Ilatovskaya DV
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Aug 31;38(16):e23891
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Aug 31;38(16):e23891
Effects on Iron Metabolism and System Xc- /GPX4 Pathway from Hydroquinone Suggest Ferroptosis of Jurkat Cells.
Liu N, Liu G, Li Q, Hu Y, Wang H
Toxics 2024 Aug 31;12(9)
Toxics 2024 Aug 31;12(9)
Sterigmatocystin declines mouse oocyte quality by inducing ferroptosis and asymmetric division defects.
Wang S, Wu X, Yang J, Peng Y, Miao F, Li M, Zeng J
Journal of ovarian research 2024 Aug 28;17(1):175
Journal of ovarian research 2024 Aug 28;17(1):175
Recharacterization of RSL3 reveals that the selenoproteome is a druggable target in colorectal cancer.
DeAngelo SL, Zhao L, Dziechciarz S, Shin M, Solanki S, Balia A, El-Derany MO, Castillo C, Qin Y, Das NK, Bell HN, Paulo JA, Zhang Y, Rossiter NJ, McCulla EC, He J, Talukder I, Ng BW, Schafer ZT, Neamati N, Mancias JD, Koutmos M, Shah YM
bioRxiv : the preprint server for biology 2024 Aug 27;
bioRxiv : the preprint server for biology 2024 Aug 27;
HO-1 activation contributes to cadmium-induced ferroptosis in renal tubular epithelial cells via increasing the labile iron pool and promoting mitochondrial ROS generation.
Lv YT, Liu TB, Li Y, Wang ZY, Lian CY, Wang L
Chemico-biological interactions 2024 Aug 25;399:111152
Chemico-biological interactions 2024 Aug 25;399:111152
Natural Product Auraptene Targets SLC7A11 for Degradation and Induces Hepatocellular Carcinoma Ferroptosis.
Li D, Li Y, Chen L, Gao C, Dai B, Yu W, Yang H, Pi J, Bian X
Antioxidants (Basel, Switzerland) 2024 Aug 20;13(8)
Antioxidants (Basel, Switzerland) 2024 Aug 20;13(8)
Taurine Alleviates Ferroptosis-Induced Metabolic Impairments in C2C12 Myoblasts by Stabilizing the Labile Iron Pool and Improving Redox Homeostasis.
Liu X, Zhou Y, Qi Z, Huang C, Lin D
Journal of proteome research 2024 Aug 2;23(8):3444-3459
Journal of proteome research 2024 Aug 2;23(8):3444-3459
CircEZH2 promotes gallbladder cancer progression and lipid metabolism reprogramming through the miR-556-5p/SCD1 axis.
Tong H, Yu X, Zhou D, Shen Z, Chen J, Si Y, Zhang L, Lu B, Yu J, Wang S, Tang Z
iScience 2024 Aug 16;27(8):110428
iScience 2024 Aug 16;27(8):110428
Tetramethylpyrazine alleviates ferroptosis and promotes functional recovery in spinal cord injury by regulating GPX4/ACSL4.
Liu G, Deng B, Huo L, Fan X, Bai H, Zhao Y, Xu L, Gao F, Mu X
European journal of pharmacology 2024 Aug 15;977:176710
European journal of pharmacology 2024 Aug 15;977:176710
Exploration and validation of therapeutic molecules for rheumatoid arthritis based on ferroptosis-related genes.
Aihaiti Y, Zheng H, Cai Y, Tuerhong X, Kaerman M, Wang F, Xu P
Life sciences 2024 Aug 15;351:122780
Life sciences 2024 Aug 15;351:122780
β-Caryophyllene Confers Cardioprotection by Scavenging Radicals and Blocking Ferroptosis.
Li Y, Wu W, Song Y, Zhang J, Han D, Shu C, Lian F, Fang X
Journal of agricultural and food chemistry 2024 Aug 14;72(32):18003-18012
Journal of agricultural and food chemistry 2024 Aug 14;72(32):18003-18012
Autophagy-mediated ferroptosis is involved in development of severe acute pancreatitis.
Li H, Wu D, Zhang H, Liu S, Zhen J, Yan Y, Li P
BMC gastroenterology 2024 Aug 1;24(1):245
BMC gastroenterology 2024 Aug 1;24(1):245
Human umbilical cord mesenchymal stem cells alleviate chemotherapy-induced premature ovarian insufficiency mouse model by suppressing ferritinophagy-mediated ferroptosis in granulosa cells.
Dai W, Xu B, Ding L, Zhang Z, Yang H, He T, Liu L, Pei X, Fu X
Free radical biology & medicine 2024 Aug 1;220:1-14
Free radical biology & medicine 2024 Aug 1;220:1-14
EGCG-NPs inhibition HO-1-mediated reprogram iron metabolism against ferroptosis after subarachnoid hemorrhage.
Huang L, Wang X, Zheng Y, Lang D, Wang J, Yan S, Chen Y
Redox biology 2024 Apr;70:103075
Redox biology 2024 Apr;70:103075
PRDX6 alleviated heart failure by inhibiting doxorubicin-induced ferroptosis through the JAK2/STAT1 pathway inactivation.
Xiong J, Zhou R, Deng X
In vitro cellular & developmental biology. Animal 2024 Apr;60(4):354-364
In vitro cellular & developmental biology. Animal 2024 Apr;60(4):354-364
SIRT5 Regulates Ferroptosis through the Nrf2/HO-1 Signaling Axis to Participate in Ischemia-Reperfusion Injury in Ischemic Stroke.
Li J, Wei G, Song Z, Chen Z, Gu J, Zhang L, Wang Z
Neurochemical research 2024 Apr;49(4):998-1007
Neurochemical research 2024 Apr;49(4):998-1007
Magnolin alleviated DSS-induced colitis by inhibiting ALOX5-mediated ferroptosis.
Yao T, Yao YY, Wang JZ, Jiang SM, Li LJ
The Kaohsiung journal of medical sciences 2024 Apr;40(4):360-373
The Kaohsiung journal of medical sciences 2024 Apr;40(4):360-373
Sulfasalazine promotes ferroptosis through AKT-ERK1/2 and P53-SLC7A11 in rheumatoid arthritis.
Zhao C, Yu Y, Yin G, Xu C, Wang J, Wang L, Zhao G, Ni S, Zhang H, Zhou B, Wang Y
Inflammopharmacology 2024 Apr;32(2):1277-1294
Inflammopharmacology 2024 Apr;32(2):1277-1294
APE1 inhibition enhances ferroptotic cell death and contributes to hepatocellular carcinoma therapy.
Du Y, Zhou Y, Yan X, Pan F, He L, Guo Z, Hu Z
Cell death and differentiation 2024 Apr;31(4):431-446
Cell death and differentiation 2024 Apr;31(4):431-446
GPX4-mediated bone ferroptosis under mechanical stress decreased bone formation via the YAP-TEAD signalling pathway.
Mengjia W, Jun J, Xin Z, Jiahao Z, Jie G
Journal of cellular and molecular medicine 2024 Apr;28(7):e18231
Journal of cellular and molecular medicine 2024 Apr;28(7):e18231
A Pt(II) complex bearing N-heterocycle ring induced ferroptotic cell death in ovarian cancer.
Shen X, Peng Y, Zhou H, Ye X, Han Z, Shi X
Journal of inorganic biochemistry 2024 Apr;253:112502
Journal of inorganic biochemistry 2024 Apr;253:112502
WDR23 mediates NRF2 proteostasis and cytoprotective capacity in the hippocampus.
Liu J, Duangjan C, Irwin RW, Curran SP
Mechanisms of ageing and development 2024 Apr;218:111914
Mechanisms of ageing and development 2024 Apr;218:111914
Copper Exposure Induced Chicken Hepatotoxicity: Involvement of Ferroptosis Mediated by Lipid Peroxidation, Ferritinophagy, and Inhibition of FSP1-CoQ10 and Nrf2/SLC7A11/GPX4 Axis.
Zhong G, Li Y, Ma F, Huo Y, Liao J, Han Q, Hu L, Tang Z
Biological trace element research 2024 Apr;202(4):1711-1721
Biological trace element research 2024 Apr;202(4):1711-1721
Identification and validation of an immunotherapeutic signature for colon cancer based on the regulatory patterns of ferroptosis and their association with the tumor microenvironment.
Liu Y, Zhao J, Huang B, Liang Y, Jiang G, Zhou X, Chen Y, He T, Zheng M, Huang Z
Biochimica et biophysica acta. Molecular cell research 2024 Apr;1871(4):119698
Biochimica et biophysica acta. Molecular cell research 2024 Apr;1871(4):119698
Co-catalpol alleviates fluoxetine-induced main toxicity: Involvement of ATF3/FSP1 signaling-mediated inhibition of ferroptosis.
Wu X, Guan Y, Wang J, Song L, Zhang Y, Wang Y, Li Y, Qin L, He Q, Zhang T, Long B, Ji L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Apr;126:155340
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Apr;126:155340
Excessive fluoride induces ovarian function impairment by regulating levels of ferroptosis in fluorosis women and ovarian granulosa cells.
Geng N, Dong S, Xie P, Zhang Y, Shi R, Chen C, Xu Z, Chen Q
Reproductive toxicology (Elmsford, N.Y.) 2024 Apr;125:108556
Reproductive toxicology (Elmsford, N.Y.) 2024 Apr;125:108556
A NRF2 Regulated and the Immunosuppressive Microenvironment Reversed Nanoplatform for Cholangiocarcinoma Photodynamic-Gas Therapy.
Wang W, Gao Y, Xu J, Zou T, Yang B, Hu S, Cheng X, Xia Y, Zheng Q
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Apr;11(14):e2307143
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Apr;11(14):e2307143
Chronic Aroclor 1260 exposure alters the mouse liver proteome, selenoproteins, and metals in steatotic liver disease.
Piell KM, Petri BJ, Xu J, Cai L, Rai SN, Li M, Wilkey DW, Merchant ML, Cave MC, Klinge CM
Environmental toxicology and pharmacology 2024 Apr;107:104430
Environmental toxicology and pharmacology 2024 Apr;107:104430
PPARγ alleviates preeclampsia development by regulating lipid metabolism and ferroptosis.
Lai W, Yu L, Deng Y
Communications biology 2024 Apr 9;7(1):429
Communications biology 2024 Apr 9;7(1):429
Design, synthesis, and evaluation of novel ferrostatin derivatives for the prevention of HG-induced VEC ferroptosis.
Wang XX, Wang RJ, Ji HL, Liu XY, Zhang NY, Wang KM, Chen K, Liu PP, Meng N, Jiang CS
RSC medicinal chemistry 2024 Apr 24;15(4):1198-1209
RSC medicinal chemistry 2024 Apr 24;15(4):1198-1209
Pharmacodynamic and Toxicity Studies of 6-Isopropyldithio-2'-guanosine Analogs in Acute T-Lymphoblastic Leukemia.
Song T, Yu Z, Shen Q, Xu Y, Hu H, Liu J, Zeng K, Lei J, Yu L
Cancers 2024 Apr 23;16(9)
Cancers 2024 Apr 23;16(9)
Medium-chain chlorinated paraffins (MCCPs) induce renal cell aging and ferroptosis.
Zhang D, Li Z, Gao Y, Sun H
Aging 2024 Apr 19;16(8):7277-7292
Aging 2024 Apr 19;16(8):7277-7292
ED-71 ameliorates bone regeneration in type 2 diabetes by reducing ferroptosis in osteoblasts via the HIF1α pathway.
Wang M, Liu Y, Gui H, Ma G, Li B, Zhang Z, Yu G, Wu A, Xu X, Zhang D
European journal of pharmacology 2024 Apr 15;969:176303
European journal of pharmacology 2024 Apr 15;969:176303
Hazel Leaf Polyphenol Extract Alleviated Cisplatin-Induced Acute Kidney Injury by Reducing Ferroptosis through Inhibiting Hippo Signaling.
Sun M, Chang H, Jiang F, Zhang W, Yang Q, Wang X, Lv G, Lin H, Luo H, Lin Z, Wang Y
Molecules (Basel, Switzerland) 2024 Apr 11;29(8)
Molecules (Basel, Switzerland) 2024 Apr 11;29(8)
Detection of Ferroptosis in Patient-Derived Tumor Models.
Zhang W, Wang Y
Methods in molecular biology (Clifton, N.J.) 2023;2712:187-197
Methods in molecular biology (Clifton, N.J.) 2023;2712:187-197
Pterostilbene Confers Protection against Diquat-Induced Intestinal Damage with Potential Regulation of Redox Status and Ferroptosis in Broiler Chickens.
Chen Y, Zhang H, Li Y, Wang T
Oxidative medicine and cellular longevity 2023;2023:8258354
Oxidative medicine and cellular longevity 2023;2023:8258354
NF-κB Inhibitor Myrislignan Induces Ferroptosis of Glioblastoma Cells via Regulating Epithelial-Mesenchymal Transformation in a Slug-Dependent Manner.
Zhou Y, Qian W, Li X, Wei W
Oxidative medicine and cellular longevity 2023;2023:7098313
Oxidative medicine and cellular longevity 2023;2023:7098313
Curcumin Induces Ferroptosis in Follicular Thyroid Cancer by Upregulating HO-1 Expression.
Chen H, Li Z, Xu J, Zhang N, Chen J, Wang G, Zhao Y
Oxidative medicine and cellular longevity 2023;2023:6896790
Oxidative medicine and cellular longevity 2023;2023:6896790
Vitronectin Destroyed Intestinal Epithelial Cell Differentiation through Activation of PDE4-Mediated Ferroptosis in Inflammatory Bowel Disease.
Pan W, Xiang L, Liang X, Du W, Zhao J, Zhang S, Zhou X, Geng L, Gong S, Xu W
Mediators of inflammation 2023;2023:6623329
Mediators of inflammation 2023;2023:6623329
Timosaponin AIII promotes non-small-cell lung cancer ferroptosis through targeting and facilitating HSP90 mediated GPX4 ubiquitination and degradation.
Zhou C, Yu T, Zhu R, Lu J, Ouyang X, Zhang Z, Chen Q, Li J, Cui J, Jiang F, Jin KY, Sarapultsev A, Li F, Zhang G, Luo S, Hu D
International journal of biological sciences 2023;19(5):1471-1489
International journal of biological sciences 2023;19(5):1471-1489
Inhibition of KMO Ameliorates Myocardial Ischemia Injury via Maintaining Mitochondrial Fusion and Fission Balance.
Lai Q, Wu L, Dong S, Zhu X, Fan Z, Kou J, Liu F, Yu B, Li F
International journal of biological sciences 2023;19(10):3077-3098
International journal of biological sciences 2023;19(10):3077-3098
Sarcoma protein kinase inhibition alleviates liver fibrosis by promoting hepatic stellate cells ferroptosis.
Cheng Z, Zhang X, Chen P, Wang H, Wang K, Shen Y
Open life sciences 2023;18(1):20220781
Open life sciences 2023;18(1):20220781
Vancomycin Induced Ferroptosis in Renal Injury Through the Inactivation of Recombinant Glutathione Peroxidase 4 and the Accumulation of Peroxides.
Yin X, Yang Q, Li H, Kang Y, Li Z
Drug design, development and therapy 2023;17:283-295
Drug design, development and therapy 2023;17:283-295
Integrated Analysis of Ferroptosis and Immunity-Related Genes Associated with Diabetic Kidney Disease.
Wang J, Wang L, Pang Z, Ge Q, Wu Y, Qi X
Diabetes, metabolic syndrome and obesity : targets and therapy 2023;16:3773-3793
Diabetes, metabolic syndrome and obesity : targets and therapy 2023;16:3773-3793
Identification of Novel Targets for Treatment of Dilated Cardiomyopathy Based on the Ferroptosis and Immune Heterogeneity.
Lu H, Xie Y, Zhou Z, Hong P, Chen J
Journal of inflammation research 2023;16:2461-2476
Journal of inflammation research 2023;16:2461-2476
Xue-Jie-San restricts ferroptosis in Crohn's disease via inhibiting FGL1/NF-κB/STAT3 positive feedback loop.
Gao Y, Zhang Z, Du J, Yang X, Wang X, Wen K, Sun X
Frontiers in pharmacology 2023;14:1148770
Frontiers in pharmacology 2023;14:1148770
Wogonin induces ferroptosis in pancreatic cancer cells by inhibiting the Nrf2/GPX4 axis.
Liu X, Peng X, Cen S, Yang C, Ma Z, Shi X
Frontiers in pharmacology 2023;14:1129662
Frontiers in pharmacology 2023;14:1129662
Metabolite Neu5Ac triggers SLC3A2 degradation promoting vascular endothelial ferroptosis and aggravates atherosclerosis progression in ApoE(-/-)mice.
Xiang P, Chen Q, Chen L, Lei J, Yuan Z, Hu H, Lu Y, Wang X, Wang T, Yu R, Zhang W, Zhang J, Yu C, Ma L
Theranostics 2023;13(14):4993-5016
Theranostics 2023;13(14):4993-5016
Depletion of PSMD14 suppresses bladder cancer proliferation by regulating GPX4.
Jia C, Zhang X, Qu T, Wu X, Li Y, Zhao Y, Sun L, Wang Q
PeerJ 2023;11:e14654
PeerJ 2023;11:e14654
Identification of EGFR as an essential regulator in chondrocytes ferroptosis of osteoarthritis using bioinformatics, in vivo, and in vitro study.
Sun H, Peng G, Chen K, Xiong Z, Zhuang Y, Liu M, Ning X, Yang H, Deng J
Heliyon 2023 Sep;9(9):e19975
Heliyon 2023 Sep;9(9):e19975
Sulforaphane, an NRF2 agonist, alleviates ferroptosis in acute liver failure by regulating HDAC6 activity.
Zhang YQ, Shi CX, Zhang DM, Zhang LY, Wang LW, Gong ZJ
Journal of integrative medicine 2023 Sep;21(5):464-473
Journal of integrative medicine 2023 Sep;21(5):464-473
Combination therapy to overcome ferroptosis resistance by biomimetic self-assembly nano-prodrug.
Huang Y, Lin Y, Li B, Zhang F, Zhan C, Xie X, Yao Z, Wu C, Ping Y, Shen J
Asian journal of pharmaceutical sciences 2023 Sep;18(5):100844
Asian journal of pharmaceutical sciences 2023 Sep;18(5):100844
Activation of Nrf2 inhibits ferroptosis and protects against oxaliplatin-induced ototoxicity.
Xu K, Chang X, Bai X, Liu HB, Chen XB, Chen HP, Liu YH
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Sep;165:115248
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Sep;165:115248
Ozone pretreatment alleviates ischemiareperfusion injury-induced myocardial ferroptosis by activating the Nrf2/Slc7a11/Gpx4 axis.
Ding S, Duanmu X, Xu L, Zhu L, Wu Z
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Sep;165:115185
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Sep;165:115185
ACSL4 promotes ferroptosis and M1 macrophage polarization to regulate the tumorigenesis of nasopharyngeal carcinoma.
Chen P, Wang D, Xiao T, Gu W, Yang H, Yang M, Wang H
International immunopharmacology 2023 Sep;122:110629
International immunopharmacology 2023 Sep;122:110629
Small extracellular vesicles from HO-1-modified bone marrow-derived mesenchymal stem cells attenuate ischemia-reperfusion injury after steatotic liver transplantation by suppressing ferroptosis via miR-214-3p.
Zuo H, Wang Y, Yuan M, Zheng W, Tian X, Pi Y, Zhang X, Song H
Cellular signalling 2023 Sep;109:110793
Cellular signalling 2023 Sep;109:110793
Metformin induces ferroptosis through the Nrf2/HO-1 signaling in lung cancer.
Deng C, Xiong L, Chen Y, Wu K, Wu J
BMC pulmonary medicine 2023 Sep 25;23(1):360
BMC pulmonary medicine 2023 Sep 25;23(1):360
Cadmium exposure promotes ferroptosis by upregulating Heat Shock Protein 70 in vascular endothelial damage of zebrafish.
Zhang T, Yan W, Liu C, Duan W, Duan Y, Li Y, Yu Q, Sun Y, Tian J, Zhou J, Xia Z, Wang G, Xu S
Ecotoxicology and environmental safety 2023 Sep 15;263:115241
Ecotoxicology and environmental safety 2023 Sep 15;263:115241
Gambogenic acid induces cell death in human osteosarcoma through altering iron metabolism, disturbing the redox balance, and activating the P53 signaling pathway.
Liu Z, Wang X, Li J, Yang X, Huang J, Ji C, Li X, Li L, Zhou J, Hu Y
Chemico-biological interactions 2023 Sep 1;382:110602
Chemico-biological interactions 2023 Sep 1;382:110602
An inducible long noncoding RNA, LncZFHX2, facilitates DNA repair to mediate osteoarthritis pathology.
Ni W, Zhang H, Mei Z, Hongyi Z, Wu Y, Xu W, Ma Y, Yang W, Liang Y, Gu T, Su Y, Fan S, Shen S, Hu Z
Redox biology 2023 Oct;66:102858
Redox biology 2023 Oct;66:102858
NRF2 Antagonizes HIV-1 Tat and Methamphetamine-Induced BV2 Cell Ferroptosis by Regulating SLC7A11.
Lin S, Cheng H, Yang G, Wang C, Leung CK, Zhang S, Tan Y, Zhang H, Wang H, Miao L, Li Y, Huang Y, Li J, Zhang R, Zeng X
Neurotoxicity research 2023 Oct;41(5):398-407
Neurotoxicity research 2023 Oct;41(5):398-407
Scutellarein alleviates chronic obstructive pulmonary disease through inhibition of ferroptosis by chelating iron and interacting with arachidonate 15-lipoxygenase.
Liu L, Zhang Y, Wang L, Liu Y, Chen H, Hu Q, Xie C, Meng X, Shen X
Phytotherapy research : PTR 2023 Oct;37(10):4587-4606
Phytotherapy research : PTR 2023 Oct;37(10):4587-4606
TRAP1 inhibits MARCH5-mediated MIC60 degradation to alleviate mitochondrial dysfunction and apoptosis of cardiomyocytes under diabetic conditions.
Zhang L, Luo Y, Lv L, Chen S, Liu G, Zhao T
Cell death and differentiation 2023 Oct;30(10):2336-2350
Cell death and differentiation 2023 Oct;30(10):2336-2350
Sonodynamic Therapy of NRP2 Monoclonal Antibody-Guided MOFs@COF Targeted Disruption of Mitochondrial and Endoplasmic Reticulum Homeostasis to Induce Autophagy-Dependent Ferroptosis.
Zhao Z, Wu Y, Liang X, Liu J, Luo Y, Zhang Y, Li T, Liu C, Luo X, Chen J, Wang Y, Wang S, Wu T, Zhang S, Yang D, Li W, Yan J, Ke Z, Luo F
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Oct;10(30):e2303872
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Oct;10(30):e2303872
Use of Deep-Learning Assisted Assessment of Cardiac Parameters in Zebrafish to Discover Cyanidin Chloride as a Novel Keap1 Inhibitor Against Doxorubicin-Induced Cardiotoxicity.
Liu C, Wang Y, Zeng Y, Kang Z, Zhao H, Qi K, Wu H, Zhao L, Wang Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Oct;10(30):e2301136
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Oct;10(30):e2301136
3β-Hydroxy-12-oleanen-27-oic Acid Exerts an Antiproliferative Effect on Human Colon Carcinoma HCT116 Cells via Targeting FDFT1.
Tu J, Meng X, Wang J, Han Z, Yu Z, Sun H
International journal of molecular sciences 2023 Oct 9;24(19)
International journal of molecular sciences 2023 Oct 9;24(19)
The clinical predictive value and regulation mechanism of microRNA-188-5p in contrast-induced acute kidney injury.
Yu R, Wu C, Xiao Y, Li Q, Chen J, Song J, Chen H, Wang Z, Wang W
Biochemical and biophysical research communications 2023 Oct 30;679:215-223
Biochemical and biophysical research communications 2023 Oct 30;679:215-223
Paeoniae Radix Rubra extract attenuates cerebral ischemia injury by inhibiting ferroptosis and activating autophagy through the PI3K/Akt signalling pathway.
Zhao F, Peng C, Li H, Chen H, Yang Y, Ai Q, Chen N, Liu F
Journal of ethnopharmacology 2023 Oct 28;315:116567
Journal of ethnopharmacology 2023 Oct 28;315:116567
Exogenous H(2)S initiating Nrf2/GPx4/GSH pathway through promoting Syvn1-Keap1 interaction in diabetic hearts.
Wang M, Tang J, Zhang S, Pang K, Zhao Y, Liu N, Huang J, Kang J, Dong S, Li H, Tian Z, Duan B, Lu F, Zhang W
Cell death discovery 2023 Oct 24;9(1):394
Cell death discovery 2023 Oct 24;9(1):394
Targeting ferroptosis attenuates podocytes injury and delays tubulointerstitial fibrosis in focal segmental glomerulosclerosis.
He X, Yang L, Wang M, Zhang P, Wang R, Ji D, Gao C, Xia Z
Biochemical and biophysical research communications 2023 Oct 20;678:11-16
Biochemical and biophysical research communications 2023 Oct 20;678:11-16
Evodiamine impairs HIF1A histone lactylation to inhibit Sema3A-mediated angiogenesis and PD-L1 by inducing ferroptosis in prostate cancer.
Yu Y, Huang X, Liang C, Zhang P
European journal of pharmacology 2023 Oct 15;957:176007
European journal of pharmacology 2023 Oct 15;957:176007
Enriched environment attenuates ferroptosis after cerebral ischemia/reperfusion injury by regulating iron metabolism.
Luo Q, Zheng J, Fan B, Liu J, Liao W, Zhang X
Brain research bulletin 2023 Oct 15;203:110778
Brain research bulletin 2023 Oct 15;203:110778
WDR23 mediates NRF2 proteostasis and cytoprotective capacity in the hippocampus.
Liu J, Duangjan C, Irwin RW, Curran SP
bioRxiv : the preprint server for biology 2023 Oct 11;
bioRxiv : the preprint server for biology 2023 Oct 11;
N-acetylcysteine attenuates the incidence of phlebitis induced by carbomer/vinorelbine gel.
Zhang H, Gong J, Zhang S, Luo L, Luo C, Bi K, Wang L, Kan X, Tian Z, Wang X
Heliyon 2023 Nov;9(11):e21235
Heliyon 2023 Nov;9(11):e21235
Heme Oxygenase-1-Modified BMMSCs Activate AMPK-Nrf2-FTH1 to Reduce Severe Steatotic Liver Ischemia-Reperfusion Injury.
Tian X, Wang Y, Yuan M, Zheng W, Zuo H, Zhang X, Song H
Digestive diseases and sciences 2023 Nov;68(11):4196-4211
Digestive diseases and sciences 2023 Nov;68(11):4196-4211
Acetyl zingerone ameliorates osteoarthritis by inhibiting chondrocyte programmed cell death.
Chen X, Chen J, Miao C, Yin G, Zhang Z, Sun R, Ni S
Molecular medicine reports 2023 Nov;28(5)
Molecular medicine reports 2023 Nov;28(5)
The ferroptosis activity is associated with neurological recovery following chronic compressive spinal cord injury.
Yu Z, Cheng X, Pan W, Yu C, Duan Y
Neural regeneration research 2023 Nov;18(11):2482-2488
Neural regeneration research 2023 Nov;18(11):2482-2488
The deubiquitinase ZRANB1 is an E3 ubiquitin ligase for SLC7A11 and regulates ferroptotic resistance.
Huang S, Zhang Q, Zhao M, Wang X, Zhang Y, Gan B, Zhang P
The Journal of cell biology 2023 Nov 6;222(11)
The Journal of cell biology 2023 Nov 6;222(11)
Extracellular vesicle-derived silk fibroin nanoparticles loaded with MFGE8 accelerate skin ulcer healing by targeting the vascular endothelial cells.
Luo L, Zhang H, Zhang S, Luo C, Kan X, Lv J, Zhao P, Tian Z, Li C
Journal of nanobiotechnology 2023 Nov 29;21(1):455
Journal of nanobiotechnology 2023 Nov 29;21(1):455
Fucoidan Ameliorates Ferroptosis in Ischemia-reperfusion-induced Liver Injury through Nrf2/HO-1/GPX4 Activation.
Li JJ, Dai WQ, Mo WH, Xu WQ, Li YY, Guo CY, Xu XF
Journal of clinical and translational hepatology 2023 Nov 28;11(6):1341-1354
Journal of clinical and translational hepatology 2023 Nov 28;11(6):1341-1354
Phenylarsine oxide induced corneal injury involves oxidative stress mediated unfolded protein response and ferroptotic cell death: Amelioration by NAC.
Kandhari K, Kant R, Mishra N, Agarwal C, Agarwal R
Free radical biology & medicine 2023 Nov 20;209(Pt 2):265-281
Free radical biology & medicine 2023 Nov 20;209(Pt 2):265-281
Activation of the Nrf-2 pathway by pinocembrin safeguards vertebral endplate chondrocytes against apoptosis and degeneration caused by oxidative stress.
Wang H, Liu X, Yang H, Jing X, Wang W, Liu X, Zhang B, Liu X, Shao Y, Cui X
Life sciences 2023 Nov 15;333:122162
Life sciences 2023 Nov 15;333:122162
Acetyl-CoA Acetyltransferase 2 Confers Radioresistance by Inhibiting Ferroptosis in Esophageal Squamous Cell Carcinoma.
Heng J, Li Z, Liu L, Zheng Z, Zheng Y, Xu X, Liao L, Xu H, Huang H, Li E, Xu L
International journal of radiation oncology, biology, physics 2023 Nov 15;117(4):966-978
International journal of radiation oncology, biology, physics 2023 Nov 15;117(4):966-978
Synergistic ferroptosis-starvation therapy for bladder cancer based on hyaluronic acid modified metal-organic frameworks.
Wang Y, Xie K, Chen W, Fang Y, Mo Q, Zhang H, Zhao X, Li D, Tan W, Zhao P, Li F
Bioengineering & translational medicine 2023 May;8(3):e10515
Bioengineering & translational medicine 2023 May;8(3):e10515
Klotho improves cardiac fibrosis, inflammatory cytokines, ferroptosis, and oxidative stress in mice with myocardial infarction.
Wang K, Li Z, Ding Y, Liu Z, Li Y, Liu X, Sun Y, Hong J, Zheng W, Qian L, Xu D
Journal of physiology and biochemistry 2023 May;79(2):341-353
Journal of physiology and biochemistry 2023 May;79(2):341-353
MELTF Might Regulate Ferroptosis, Pyroptosis, and Autophagy in Platelet-Rich Plasma-Mediated Endometrial Epithelium Regeneration.
Mao Y, Wang M, Xiong Y, Wen X, Zhang M, Ma L, Zhang Y
Reproductive sciences (Thousand Oaks, Calif.) 2023 May;30(5):1506-1520
Reproductive sciences (Thousand Oaks, Calif.) 2023 May;30(5):1506-1520
Ambient particulate matter exposure plus chronic ethanol ingestion exacerbates hepatic fibrosis by triggering the mitochondrial ROS-ferroptosis signaling pathway in mice.
Ding S, Jiang J, Zhang G, Yu M, Zheng Y
Ecotoxicology and environmental safety 2023 May;256:114897
Ecotoxicology and environmental safety 2023 May;256:114897
CDGSH iron sulfur domain 2 over-expression alleviates neuronal ferroptosis and brain injury by inhibiting lipid peroxidation via AKT/mTOR pathway following intracerebral hemorrhage in mice.
Li R, Zhang X, Gu L, Yuan Y, Luo X, Shen W, Xie Z
Journal of neurochemistry 2023 May;165(3):426-444
Journal of neurochemistry 2023 May;165(3):426-444
Autophagy inhibition and ferroptosis activation during atherosclerosis: Hypoxia-inducible factor 1α inhibitor PX-478 alleviates atherosclerosis by inducing autophagy and suppressing ferroptosis in macrophages.
Hu G, Yuan Z, Wang J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 May;161:114333
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 May;161:114333
An ultrasensitive GSH-specific fluorescent probe unveils celastrol-induced ccRCC ferroptosis.
Li H, Deng C, Zhu N, Zhang C, Zeng Q, Qin L
Bioorganic chemistry 2023 May;134:106454
Bioorganic chemistry 2023 May;134:106454
Polydopamine Nanoparticles Targeting Ferroptosis Mitigate Intervertebral Disc Degeneration Via Reactive Oxygen Species Depletion, Iron Ions Chelation, and GPX4 Ubiquitination Suppression.
Yang X, Chen Y, Guo J, Li J, Zhang P, Yang H, Rong K, Zhou T, Fu J, Zhao J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 May;10(13):e2207216
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 May;10(13):e2207216
Bisphenol A induces testicular oxidative stress in mice leading to ferroptosis.
Li L, Wang MY, Jiang HB, Guo CR, Zhu XD, Yao XQ, Zeng WW, Zhao Y, Chi LK
Asian journal of andrology 2023 May-Jun;25(3):375-381
Asian journal of andrology 2023 May-Jun;25(3):375-381
Rhein Inhibited Ferroptosis and EMT to Attenuate Diabetic Nephropathy by Regulating the Rac1/NOX1/β-Catenin Axis.
Xiong D, Hu W, Han X, Cai Y
Frontiers in bioscience (Landmark edition) 2023 May 25;28(5):100
Frontiers in bioscience (Landmark edition) 2023 May 25;28(5):100
DiDang decoction improves mitochondrial function and lipid metabolism via the HIF-1 signaling pathway to treat atherosclerosis and hyperlipidemia.
Wu X, Pan J, Yu JJ, Kang J, Hou S, Cheng M, Xu L, Gong L, Li Y
Journal of ethnopharmacology 2023 May 23;308:116289
Journal of ethnopharmacology 2023 May 23;308:116289
Epigenetically silenced lncRNA SNAI3-AS1 promotes ferroptosis in glioma via perturbing the m(6)A-dependent recognition of Nrf2 mRNA mediated by SND1.
Zheng J, Zhang Q, Zhao Z, Qiu Y, Zhou Y, Wu Z, Jiang C, Wang X, Jiang X
Journal of experimental & clinical cancer research : CR 2023 May 19;42(1):127
Journal of experimental & clinical cancer research : CR 2023 May 19;42(1):127
TRIM21 ubiquitylates GPX4 and promotes ferroptosis to aggravate ischemia/reperfusion-induced acute kidney injury.
Sun X, Huang N, Li P, Dong X, Yang J, Zhang X, Zong WX, Gao S, Xin H
Life sciences 2023 May 15;321:121608
Life sciences 2023 May 15;321:121608
Supression Thioredoxin reductase 3 exacerbates the progression of liver cirrhosis via activation of ferroptosis pathway.
Liu Q, Xu L, Ren G, Zhao J, Shao Y, Lu T
Life sciences 2023 May 15;321:121591
Life sciences 2023 May 15;321:121591
Reversal of H(2)O(2)-induced cell death by knockdown of HOTAIR in HTR-8/SVneo cells by mediation of miR-106b-5p/ACSL4 axis.
Cao M, Jin W, Li Y, Wang M, Wan F, Ren Y, Gu Y, Ma J, Zhang L
Functional & integrative genomics 2023 May 15;23(2):161
Functional & integrative genomics 2023 May 15;23(2):161
PM(2.5) caused ferroptosis in spermatocyte via overloading iron and disrupting redox homeostasis.
Wang J, Zhang Z, Shi F, Li Y, Tang Y, Liu C, Wang Y, Chen J, Jiang X, Yang H, Sun L, Chen Q, Ao L, Han F, Liu J, Cao J
The Science of the total environment 2023 May 10;872:162089
The Science of the total environment 2023 May 10;872:162089
Liberation of daidzein by gut microbial β-galactosidase suppresses acetaminophen-induced hepatotoxicity in mice.
Zeng Y, Wu R, Wang F, Li S, Li L, Li Y, Qin P, Wei M, Yang J, Wu J, Chen A, Ke G, Yan Z, Yang H, Chen Z, Wang Z, Xiao W, Jiang Y, Chen X, Zeng Z, Zhao X, Chen P, Gong S
Cell host & microbe 2023 May 10;31(5):766-780.e7
Cell host & microbe 2023 May 10;31(5):766-780.e7
Hepatocyte ferroptosis contributes to anti-tuberculosis drug-induced liver injury: Involvement of the HIF-1α/SLC7A11/GPx4 axis.
Liu Y, Chen W, Cen Y, Zhao X, Chen Z, Liang Y, Huang Z, He X, Yang G
Chemico-biological interactions 2023 May 1;376:110439
Chemico-biological interactions 2023 May 1;376:110439
Effects of icariin and curcumol on autophagy, ferroptosis, and lipid metabolism based on miR-7/m-TOR/SREBP1 pathway on prostate cancer.
Xu W, Ding J, Li B, Sun T, You X, He Q, Sheng W
BioFactors (Oxford, England) 2023 Mar;49(2):438-456
BioFactors (Oxford, England) 2023 Mar;49(2):438-456
Uridine Alleviates Sepsis-Induced Acute Lung Injury by Inhibiting Ferroptosis of Macrophage.
Lai K, Song C, Gao M, Deng Y, Lu Z, Li N, Geng Q
International journal of molecular sciences 2023 Mar 7;24(6)
International journal of molecular sciences 2023 Mar 7;24(6)
HSPA5 Promotes the Proliferation, Metastasis and Regulates Ferroptosis of Bladder Cancer.
Wang Q, Ke S, Liu Z, Shao H, He M, Guo J
International journal of molecular sciences 2023 Mar 7;24(6)
International journal of molecular sciences 2023 Mar 7;24(6)
A Novel Three-Dimensional Follicle Culture System Decreases Oxidative Stress and Promotes the Prolonged Culture of Human Granulosa Cells.
Zhao X, Zhang S, Gao S, Chang HM, Leung PCK, Tan J
ACS applied materials & interfaces 2023 Mar 29;15(12):15084-15095
ACS applied materials & interfaces 2023 Mar 29;15(12):15084-15095
PTEN inhibitor VO-OHpic protects endplate chondrocytes against apoptosis and calcification via activating Nrf-2 signaling pathway.
Cui X, Liu X, Kong P, Du T, Li T, Yang G, Zhang W, Jing X, Wang W
Aging 2023 Mar 24;15(6):2275-2292
Aging 2023 Mar 24;15(6):2275-2292
Toosendanin induced hepatotoxicity via triggering PERK-eIF2α-ATF4 mediated ferroptosis.
Liang Y, Chen S, Han S, Luo L, Shen F, Huang Z
Toxicology letters 2023 Mar 15;377:51-61
Toxicology letters 2023 Mar 15;377:51-61
TRIM25 promotes temozolomide resistance in glioma by regulating oxidative stress and ferroptotic cell death via the ubiquitination of keap1.
Wei J, Wang L, Zhang Y, Sun T, Zhang C, Hu Z, Zhou L, Liu X, Wan J, Ma L
Oncogene 2023 Jun;42(26):2103-2112
Oncogene 2023 Jun;42(26):2103-2112
Employing single valency polyphenol to prepare metal-phenolic network antitumor reagents through FeOOH assistance.
Zhang M, Wang L, Jin H, Zhao N, Liu Y, Lan S, Liu S, Zhang H
Journal of controlled release : official journal of the Controlled Release Society 2023 Jun;358:612-625
Journal of controlled release : official journal of the Controlled Release Society 2023 Jun;358:612-625
BACH1 promotes intervertebral disc degeneration by regulating HMOX1/GPX4 to mediate oxidative stress, ferroptosis, and lipid metabolism in nucleus pulposus cells.
Yao B, Cai Y, Wan L, Deng J, Zhao L, Wang W, Han Z
The journal of gene medicine 2023 Jun;25(6):e3488
The journal of gene medicine 2023 Jun;25(6):e3488
Astaxanthin suppresses oxidative stress and calcification in vertebral cartilage endplate via activating Nrf-2/HO-1 signaling pathway.
Yang G, Liu X, Jing X, Wang J, Wang H, Chen F, Wang W, Shao Y, Cui X
International immunopharmacology 2023 Jun;119:110159
International immunopharmacology 2023 Jun;119:110159
PRMT5 reduces immunotherapy efficacy in triple-negative breast cancer by methylating KEAP1 and inhibiting ferroptosis.
Wang Z, Li R, Hou N, Zhang J, Wang T, Fan P, Ji C, Zhang B, Liu L, Wang Y, Kong J, Yao Q, Duan J, Zhao G, Ling R, Zhang J
Journal for immunotherapy of cancer 2023 Jun;11(6)
Journal for immunotherapy of cancer 2023 Jun;11(6)
Terpinen-4-ol Induces Ferroptosis of Glioma Cells via Downregulating JUN Proto-Oncogene.
Cao W, Li Y, Zeng Z, Lei S
Molecules (Basel, Switzerland) 2023 Jun 8;28(12)
Molecules (Basel, Switzerland) 2023 Jun 8;28(12)
Pien-Tze-Huang prevents hepatocellular carcinoma by inducing ferroptosis via inhibiting SLC7A11-GSH-GPX4 axis.
Yan X, Liu Y, Li C, Mao X, Xu T, Hu Z, Zhang C, Lin N, Lin Y, Zhang Y
Cancer cell international 2023 Jun 6;23(1):109
Cancer cell international 2023 Jun 6;23(1):109
Dihydroorotate dehydrogenase regulates ferroptosis in neurons after spinal cord injury via the P53-ALOX15 signaling pathway.
Li D, Lu X, Xu G, Liu S, Gong Z, Lu F, Xia X, Jiang J, Wang H, Zou F, Ma X
CNS neuroscience & therapeutics 2023 Jul;29(7):1923-1939
CNS neuroscience & therapeutics 2023 Jul;29(7):1923-1939
SIRT3-mediated autophagy contributes to ferroptosis-induced anticancer by inducing the formation of BECN1-SLC7A11 complex.
Huang P, Zhao H, Pan X, Li J, Pan W, Dai H, Wang J, Xia C, Liu F
Biochemical pharmacology 2023 Jul;213:115592
Biochemical pharmacology 2023 Jul;213:115592
Ferrostatin-1 alleviates the damage of C2C12 myoblast and mouse pelvic floor muscle induced by mechanical trauma.
He Y, Huang G, Hong S, Zuo X, Zhao Z, Hong L
Cell death discovery 2023 Jul 7;9(1):232
Cell death discovery 2023 Jul 7;9(1):232
The effect of ferroptosis - related proteins and histone deacetylases1 on neoadjuvant chemotherapy in breast cancer.
Sun H, Lin Y, Liu J, Zheng X, Wang Y, Cai J, Wei X
Medicine 2023 Jul 28;102(30):e34444
Medicine 2023 Jul 28;102(30):e34444
SATB1/SLC7A11/HO-1 Axis Ameliorates Ferroptosis in Neuron Cells After Ischemic Stroke by Danhong Injection.
Zhan S, Liang J, Lin H, Cai J, Yang X, Wu H, Wei J, Wang S, Xian M
Molecular neurobiology 2023 Jan;60(1):413-427
Molecular neurobiology 2023 Jan;60(1):413-427
Elabela blunts doxorubicin-induced oxidative stress and ferroptosis in rat aortic adventitial fibroblasts by activating the KLF15/GPX4 signaling.
Zhang MW, Li XT, Zhang ZZ, Liu Y, Song JW, Liu XM, Chen YH, Wang N, Guo Y, Liang LR, Zhong JC
Cell stress & chaperones 2023 Jan;28(1):91-103
Cell stress & chaperones 2023 Jan;28(1):91-103
Dexmedetomidine attenuates airway inflammation and oxidative stress in asthma via the Nrf2 signaling pathway.
Xiao S, Zhou Y, Gao H, Yang D
Molecular medicine reports 2023 Jan;27(1)
Molecular medicine reports 2023 Jan;27(1)
A novel 3-phenylglutaric acid derivative (84-B10) alleviates cisplatin-induced acute kidney injury by inhibiting mitochondrial oxidative stress-mediated ferroptosis.
Fan J, Xu X, Li Y, Zhang L, Miao M, Niu Y, Zhang Y, Zhang A, Jia Z, Wu M
Free radical biology & medicine 2023 Jan;194:84-98
Free radical biology & medicine 2023 Jan;194:84-98
Fibroblast ferroptosis is involved in periodontitis-induced tissue damage and bone loss.
Xing L, Dong W, Chen Y, Dai W, Xiao X, Liu Z, Zhang X, Bai D, Xu H
International immunopharmacology 2023 Jan;114:109607
International immunopharmacology 2023 Jan;114:109607
Paeonol ameliorates endometrial hyperplasia in mice via inhibiting PI3K/AKT pathway-related ferroptosis.
Liu S, Cao X, Zhang T, Zhang C, Qu J, Sun Y, Lv W, Qu F
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jan;109:154593
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jan;109:154593
Dendrobium Nobile Polysaccharides Attenuates Ferroptosis and Improves Cognitive Function in Vascular Dementia Rats.
Ming M, Hu W, Xie G, Chen J, Huang Y
American journal of Alzheimer's disease and other dementias 2023 Jan-Dec;38:15333175231185236
American journal of Alzheimer's disease and other dementias 2023 Jan-Dec;38:15333175231185236
Yiqi Chutan Formula Reverses Cisplatin-Induced Apoptosis and Ferroptosis of Skeletal Muscle by Alleviating Oxidative Stress.
Wu Y, Pi D, Zhou S, Wang W, Ye H, Yi Z, Chen Y, Ouyang M
Integrative cancer therapies 2023 Jan-Dec;22:15347354231172117
Integrative cancer therapies 2023 Jan-Dec;22:15347354231172117
Hyperforin Elicits Cytostatic/Cytotoxic Activity in Human Melanoma Cell Lines, Inhibiting Pro-Survival NF-κB, STAT3, AP1 Transcription Factors and the Expression of Functional Proteins Involved in Mitochondrial and Cytosolic Metabolism.
Cardile A, Zanrè V, Campagnari R, Asson F, Addo SS, Orlandi E, Menegazzi M
International journal of molecular sciences 2023 Jan 9;24(2)
International journal of molecular sciences 2023 Jan 9;24(2)
SGK2 promotes prostate cancer metastasis by inhibiting ferroptosis via upregulating GPX4.
Cheng L, He Q, Liu B, Chen L, Lv F, Li X, Li Y, Liu C, Song Y, Xing Y
Cell death & disease 2023 Jan 31;14(1):74
Cell death & disease 2023 Jan 31;14(1):74
Qing-Xin-Jie-Yu Granule inhibits ferroptosis and stabilizes atherosclerotic plaques by regulating the GPX4/xCT signaling pathway.
Zhang J, Wang X, Guan B, Wang X, An X, Wang T, Chen X, Zhao L, Jia J, Song L, Ma D, Li Q, Zhang H, Ju J, Xu H
Journal of ethnopharmacology 2023 Jan 30;301:115852
Journal of ethnopharmacology 2023 Jan 30;301:115852
Berberine hydrochloride alleviates imatinib mesylate - induced cardiotoxicity through the inhibition of Nrf2-dependent ferroptosis.
Song C, Li D, Zhang J, Zhao X
Food & function 2023 Jan 23;14(2):1087-1098
Food & function 2023 Jan 23;14(2):1087-1098
The natural flavone acacetin protects against high-fat diet-induced lipid accumulation in the liver via the endoplasmic reticulum stress/ferroptosis pathway.
Jiang Z, Sun H, Miao J, Sheng Q, Xu J, Gao Z, Zhang X, Song Y, Chen K
Biochemical and biophysical research communications 2023 Jan 15;640:183-191
Biochemical and biophysical research communications 2023 Jan 15;640:183-191
Lipocalin 2 induces visual impairment by promoting ferroptosis in retinal ischemia-reperfusion injury.
Mei T, Wu J, Wu K, Zhao M, Luo J, Liu X, Shang B, Xu W, Yang Z, Lai Y, Liu C, Gong H, Gao X, Zhuo Y, Lin M, Zhao L
Annals of translational medicine 2023 Jan 15;11(1):3
Annals of translational medicine 2023 Jan 15;11(1):3
Effects of ferroptosis in myocardial ischemia/reperfusion model of rat and its association with Sestrin 1.
Yang F, Wang W, Zhang Y, Nong J, Zhang L
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2023 Feb;32(2):219-231
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2023 Feb;32(2):219-231
Glutathione ameliorates the meiotic defects of copper exposed ovine oocytes via inhibiting the mitochondrial dysfunctions.
Ren J, Wang B, Li L, Li S, Ma Y, Su L, Liu G, Liu Y, Dai Y
Ecotoxicology and environmental safety 2023 Feb;251:114530
Ecotoxicology and environmental safety 2023 Feb;251:114530
Triterpenoids from Uncaria macrophylla as ferroptosis inhibitors.
Liang X, Wei Y, Hou X, Guo Q, Liang H, Zeng K, Tu P, Zhang Q
Phytochemistry 2023 Feb;206:113530
Phytochemistry 2023 Feb;206:113530
Transcriptome analysis highlights the role of ferroptosis in palmitic acid-induced endothelial dysfunction.
Tan XH, Gu YY, Song WP, Nan TG, Song WD, Fang D, Yuan YM, Xin ZC, Li XS, Guan RL
Sexual medicine 2023 Feb;11(1):qfac008
Sexual medicine 2023 Feb;11(1):qfac008
Neurotoxic A1 astrocytes promote neuronal ferroptosis via CXCL10/CXCR3 axis in epilepsy.
Liang P, Zhang X, Zhang Y, Wu Y, Song Y, Wang X, Chen T, Liu W, Peng B, Yin J, He F, Fan Y, Han S, He X
Free radical biology & medicine 2023 Feb 1;195:329-342
Free radical biology & medicine 2023 Feb 1;195:329-342
The SIRT3 activator ganoderic acid D regulates airway mucin MUC5AC expression via the NRF2/GPX4 pathway.
Wang J, Li J, He Y, Huang X, Feng J, Liu L, Liu Y, Jiang X, Jia J
Pulmonary pharmacology & therapeutics 2023 Dec;83:102262
Pulmonary pharmacology & therapeutics 2023 Dec;83:102262
Mesenchymal stem cells-derived exosomes ameliorate high glucose and lipopolysaccharide-induced HPMECs injury through the Nrf2/HO-1 pathway.
Sun H, Lu S, Qu G, Li J, Song B
Autoimmunity 2023 Dec;56(1):2290357
Autoimmunity 2023 Dec;56(1):2290357
Curcumin strengthens a spontaneous self-protective mechanism-SP1/PRDX6 pathway, against di-n-butyl phthalate-induced testicular ferroptosis damage.
Bu H, Wang B, Wu Y, Li P, Cui Y, Jiang X, Yu X, Liu B, Tang M
Environmental science and pollution research international 2023 Dec;30(58):122165-122181
Environmental science and pollution research international 2023 Dec;30(58):122165-122181
Xanthohumol attenuates renal ischemia/reperfusion injury by inhibiting ferroptosis.
Tang Z, Feng Y, Nie W, Li C
Experimental and therapeutic medicine 2023 Dec;26(6):571
Experimental and therapeutic medicine 2023 Dec;26(6):571
PUFAs add fuel to Crohn's disease-associated AIEC-induced enteritis by exacerbating intestinal epithelial lipid peroxidation.
Wen W, Xu Y, Qian W, Huang L, Gong J, Li Y, Zhu W, Guo Z
Gut microbes 2023 Dec;15(2):2265578
Gut microbes 2023 Dec;15(2):2265578
Eicosapentaenoic acid enhances the sensitivity of osteosarcoma to cisplatin by inducing ferroptosis through the DNA-PKcs/AKT/NRF2 pathway and reducing PD-L1 expression to attenuate immune evasion.
Zhang Y, Shen G, Meng T, Lv Z, Li X, Li J, Li K
International immunopharmacology 2023 Dec;125(Pt B):111181
International immunopharmacology 2023 Dec;125(Pt B):111181
β-aminoisobutyrics acid, a metabolite of BCAA, activates the AMPK/Nrf-2 pathway to prevent ferroptosis and ameliorates lung ischemia-reperfusion injury.
Zhang Z, Li X, Guo J, He B, Wu L, Yang R, Li X, Fang D, Yang X, Yang D, Wang F, Tang M, Han Y, Jose PA, Wang H, Zeng C
Molecular medicine (Cambridge, Mass.) 2023 Dec 4;29(1):164
Molecular medicine (Cambridge, Mass.) 2023 Dec 4;29(1):164
Imatinib induces ferroptosis in gastrointestinal stromal tumors by promoting STUB1-mediated GPX4 ubiquitination.
Sun X, Zhang Q, Lin X, Shu P, Gao X, Shen K
Cell death & disease 2023 Dec 18;14(12):839
Cell death & disease 2023 Dec 18;14(12):839
Overexpression of FSP1 Ameliorates ferroptosis via PI3K/ AKT /GSK3β pathway in PC12 cells with Oxygen-Glucose Deprivation/Reoxygenation.
Wu Y, Shi H, Zheng J, Yang Y, Lei X, Qian X, Zhu J
Heliyon 2023 Aug;9(8):e18449
Heliyon 2023 Aug;9(8):e18449
A potent phosphodiester Keap1-Nrf2 protein-protein interaction inhibitor as the efficient treatment of Alzheimer's disease.
Sun Y, Xu L, Zheng D, Wang J, Liu G, Mo Z, Liu C, Zhang W, Yu J, Xing C, He L, Zhuang C
Redox biology 2023 Aug;64:102793
Redox biology 2023 Aug;64:102793
Effect of P53 nuclear localization mediated by G3BP1 on ferroptosis in acute liver failure.
Li W, Li W, Li X, Wang L, Wang Y
Apoptosis : an international journal on programmed cell death 2023 Aug;28(7-8):1226-1240
Apoptosis : an international journal on programmed cell death 2023 Aug;28(7-8):1226-1240
Role of Escin in breast cancer therapy: potential mechanism for inducing ferroptosis and synergistic antitumor activity with cisplatin.
Li C, He Z, Yao F, Liao S, Sun K, Sun S, Li Z, Wang Z
Apoptosis : an international journal on programmed cell death 2023 Aug;28(7-8):1154-1167
Apoptosis : an international journal on programmed cell death 2023 Aug;28(7-8):1154-1167
ETS1 Ameliorates Hyperoxia-Induced Bronchopulmonary Dysplasia in Mice by Activating Nrf2/HO-1 Mediated Ferroptosis.
Yang M, Chen Y, Huang X, Shen F, Meng Y
Lung 2023 Aug;201(4):425-441
Lung 2023 Aug;201(4):425-441
Gegen Qinlian decoction (GQD) inhibits ulcerative colitis by modulating ferroptosis-dependent pathway in mice and organoids.
Wang X, Quan J, Xiu C, Wang J, Zhang J
Chinese medicine 2023 Aug 30;18(1):110
Chinese medicine 2023 Aug 30;18(1):110
Ficolin B secreted by alveolar macrophage exosomes exacerbates bleomycin-induced lung injury via ferroptosis through the cGAS-STING signaling pathway.
Wu X, Jiang Y, Li R, Xia Y, Li F, Zhao M, Li G, Tan X
Cell death & disease 2023 Aug 30;14(8):577
Cell death & disease 2023 Aug 30;14(8):577
MEN1 is a regulator of alternative splicing and prevents R-loop-induced genome instability through suppression of RNA polymerase II elongation.
Jin B, Zhu J, Pan T, Yang Y, Liang L, Zhou Y, Zhang T, Teng Y, Wang Z, Wang X, Tian Q, Guo B, Li H, Chen T
Nucleic acids research 2023 Aug 25;51(15):7951-7971
Nucleic acids research 2023 Aug 25;51(15):7951-7971
CXCL8 Promotes Endothelial-to-Mesenchymal Transition of Endothelial Cells and Protects Cells from Erastin-Induced Ferroptosis via CXCR2-Mediated Activation of the NF-κB Signaling Pathway.
Ji HZ, Chen L, Ren M, Li S, Liu TY, Chen HJ, Yu HH, Sun Y
Pharmaceuticals (Basel, Switzerland) 2023 Aug 25;16(9)
Pharmaceuticals (Basel, Switzerland) 2023 Aug 25;16(9)
Knockdown of SETD2 promotes erastin-induced ferroptosis in ccRCC.
Xue W, Jian W, Meng Y, Wang T, Cai L, Yu Y, Yu Y, Xia Z, Zhang C
Cell death & disease 2023 Aug 21;14(8):539
Cell death & disease 2023 Aug 21;14(8):539
Overexpression of GPX4 attenuates cognitive dysfunction through inhibiting hippocampus ferroptosis and neuroinflammation after traumatic brain injury.
Fang J, Yuan Q, Du Z, Zhang Q, Yang L, Wang M, Yang W, Yuan C, Yu J, Wu G, Hu J
Free radical biology & medicine 2023 Aug 1;204:68-81
Free radical biology & medicine 2023 Aug 1;204:68-81
Targeting the Na(+)/K(+) ATPase DR-region with DR-Ab improves doxorubicin-induced cardiotoxicity.
Leng B, Deng L, Tan J, Lee WT, Cao CR, Wang ZP, Huang DJ, Nie X, Bian JS
Free radical biology & medicine 2023 Aug 1;204:38-53
Free radical biology & medicine 2023 Aug 1;204:38-53
Ketogenic diet alleviates brain iron deposition and cognitive dysfunction via Nrf2-mediated ferroptosis pathway in APP/PS1 mouse.
Qin Y, Bai D, Tang M, Zhang M, Zhao L, Li J, Yang R, Jiang G
Brain research 2023 Aug 1;1812:148404
Brain research 2023 Aug 1;1812:148404
Erythropoietin inhibits ferroptosis and ameliorates neurological function after spinal cord injury.
Kang Y, Zhu R, Li S, Qin KP, Tang H, Shan WS, Yin ZS
Neural regeneration research 2023 Apr;18(4):881-888
Neural regeneration research 2023 Apr;18(4):881-888
Matrine alleviates oxidative stress and ferroptosis in severe acute pancreatitis-induced acute lung injury by activating the UCP2/SIRT3/PGC1α pathway.
Jin H, Zhao K, Li J, Xu Z, Liao S, Sun S
International immunopharmacology 2023 Apr;117:109981
International immunopharmacology 2023 Apr;117:109981
Water extract from Herpetospermum pedunculosum attenuates oxidative stress and ferroptosis induced by acetaminophen via regulating Nrf2 and NF-κB pathways.
Li J, Lu Q, Peng M, Liao J, Zhang B, Yang D, Huang P, Yang Y, Zhao Q, Han B, Li J
Journal of ethnopharmacology 2023 Apr 6;305:116069
Journal of ethnopharmacology 2023 Apr 6;305:116069
Combination treatment with FAAH inhibitors/URB597 and ferroptosis inducers significantly decreases the growth and metastasis of renal cell carcinoma cells via the PI3K-AKT signaling pathway.
Hao J, Chen Q, Feng Y, Jiang Q, Sun H, Deng B, Huang X, Guan J, Chen Q, Liu X, Wang Y, Cao P, Feng F, Li X
Cell death & disease 2023 Apr 6;14(4):247
Cell death & disease 2023 Apr 6;14(4):247
Butyrate dictates ferroptosis sensitivity through FFAR2-mTOR signaling.
Wang G, Qin S, Chen L, Geng H, Zheng Y, Xia C, Yao J, Deng L
Cell death & disease 2023 Apr 25;14(4):292
Cell death & disease 2023 Apr 25;14(4):292
Glucose Starvation Inhibits Ferroptosis by Activating the LKB1/AMPK Signaling Pathway and Promotes the High Speed Linear Motility of Dairy Goat Sperm.
Li Y, Zhang G, Wen F, Xian M, Guo S, Zhang X, Feng X, Hu Z, Hu J
Animals : an open access journal from MDPI 2023 Apr 23;13(9)
Animals : an open access journal from MDPI 2023 Apr 23;13(9)
Ginsenoside Rh3 induces pyroptosis and ferroptosis through the Stat3/p53/NRF2 axis in colorectal cancer cells.
Wu Y, Pi D, Zhou S, Yi Z, Dong Y, Wang W, Ye H, Chen Y, Zuo Q, Ouyang M
Acta biochimica et biophysica Sinica 2023 Apr 19;55(4):587-600
Acta biochimica et biophysica Sinica 2023 Apr 19;55(4):587-600
Mitoglitazone ameliorates renal ischemia/reperfusion injury by inhibiting ferroptosis via targeting mitoNEET.
Qi Y, Hu M, Qiu Y, Zhang L, Yan Y, Feng Y, Feng C, Hou X, Wang Z, Zhang D, Zhao J
Toxicology and applied pharmacology 2023 Apr 15;465:116440
Toxicology and applied pharmacology 2023 Apr 15;465:116440
Ferroptosis mediates decabromodiphenyl ether-induced liver damage and inflammation.
Wang Y, Zhang Y, Xue J, Gao L, Li X, Zhao M, Zhao D, Zhou X
Ecotoxicology and environmental safety 2023 Apr 15;255:114771
Ecotoxicology and environmental safety 2023 Apr 15;255:114771
Hydrogen Sulfide Inhibits Ferroptosis in Cardiomyocytes to Protect Cardiac Function in Aging Rats.
Liang Z, Miao Y, Teng X, Xiao L, Guo Q, Xue H, Tian D, Jin S, Wu Y
Frontiers in molecular biosciences 2022;9:947778
Frontiers in molecular biosciences 2022;9:947778
Edaravone Ameliorates Cerebral Ischemia-Reperfusion Injury by Downregulating Ferroptosis via the Nrf2/FPN Pathway in Rats.
Liu W, Wang L, Liu C, Dai Z, Li T, Tang B
Biological & pharmaceutical bulletin 2022;45(9):1269-1275
Biological & pharmaceutical bulletin 2022;45(9):1269-1275
Effect of one-time high load exercise on skeletal muscle injury in rats of different genders: oxidative stress and mitochondrial responses.
Wang Y, Chen M, Gao Y, He K, Yang Z, Li Y, Zhang S, Zhao L
Acta cirurgica brasileira 2022;37(8):e370805
Acta cirurgica brasileira 2022;37(8):e370805
Attenuation by Time-Restricted Feeding of High-Fat and High-Fructose Diet-Induced NASH in Mice Is Related to Per2 and Ferroptosis.
Shu YY, Gao WK, Chu HK, Yang L, Pan XL, Ye J
Oxidative medicine and cellular longevity 2022;2022:8063897
Oxidative medicine and cellular longevity 2022;2022:8063897
Cryptotanshinone Protects against PCOS-Induced Damage of Ovarian Tissue via Regulating Oxidative Stress, Mitochondrial Membrane Potential, Inflammation, and Apoptosis via Regulating Ferroptosis.
Liu H, Xie J, Fan L, Xia Y, Peng X, Zhou J, Ni X
Oxidative medicine and cellular longevity 2022;2022:8011850
Oxidative medicine and cellular longevity 2022;2022:8011850
TUG1/MAZ/FTH1 Axis Attenuates the Antiglioma Effect of Dihydroartemisinin by Inhibiting Ferroptosis.
Gong H, Gao M, Lin Y, Liu J, Hu Z, Liu J
Oxidative medicine and cellular longevity 2022;2022:7843863
Oxidative medicine and cellular longevity 2022;2022:7843863
miR-29a-3p in Exosomes from Heme Oxygenase-1 Modified Bone Marrow Mesenchymal Stem Cells Alleviates Steatotic Liver Ischemia-Reperfusion Injury in Rats by Suppressing Ferroptosis via Iron Responsive Element Binding Protein 2.
Li X, Wu L, Tian X, Zheng W, Yuan M, Tian X, Zuo H, Song H, Shen Z
Oxidative medicine and cellular longevity 2022;2022:6520789
Oxidative medicine and cellular longevity 2022;2022:6520789
miR-127-5p Targets JAM3 to Regulate Ferroptosis, Proliferation, and Metastasis in Malignant Meningioma Cells.
Zhang J, Liu Z, Dong Y
Disease markers 2022;2022:6423237
Disease markers 2022;2022:6423237
Ginsenoside Rh4 Inhibits Colorectal Cancer Cell Proliferation by Inducing Ferroptosis via Autophagy Activation.
Wu Y, Pi D, Chen Y, Zuo Q, Zhou S, Ouyang M
Evidence-based complementary and alternative medicine : eCAM 2022;2022:6177553
Evidence-based complementary and alternative medicine : eCAM 2022;2022:6177553
Melatonin Alleviates Acute Kidney Injury by Inhibiting NRF2/Slc7a11 Axis-Mediated Ferroptosis.
Huang YB, Jiang L, Liu XQ, Wang X, Gao L, Zeng HX, Zhu W, Hu XR, Wu YG
Oxidative medicine and cellular longevity 2022;2022:4776243
Oxidative medicine and cellular longevity 2022;2022:4776243
Atorvastatin Inhibits Ferroptosis of H9C2 Cells by regulatingSMAD7/Hepcidin Expression to Improve Ischemia-Reperfusion Injury.
Peng Y, Liao B, Zhou Y, Zeng W, Zeng ZY
Cardiology research and practice 2022;2022:3972829
Cardiology research and practice 2022;2022:3972829
SLC7A11/GPX4 Inactivation-Mediated Ferroptosis Contributes to the Pathogenesis of Triptolide-Induced Cardiotoxicity.
Liu X, Chen C, Han D, Zhou W, Cui Y, Tang X, Xiao C, Wang Y, Gao Y
Oxidative medicine and cellular longevity 2022;2022:3192607
Oxidative medicine and cellular longevity 2022;2022:3192607
Artemether attenuates renal tubular injury by regulating iron metabolism in mice with streptozotocin-induced diabetes.
Rong G, Cai Y, Weng W, Chen Y, Yu X, Shao M, Han P, Sun H
American journal of translational research 2022;14(9):6095-6106
American journal of translational research 2022;14(9):6095-6106
Icariin protects vertebral endplate chondrocytes against apoptosis and degeneration via activating Nrf-2/HO-1 pathway.
Shao Y, Sun L, Yang G, Wang W, Liu X, Du T, Chen F, Jing X, Cui X
Frontiers in pharmacology 2022;13:937502
Frontiers in pharmacology 2022;13:937502
Targeting Mitochondrial ROS-Mediated Ferroptosis by Quercetin Alleviates High-Fat Diet-Induced Hepatic Lipotoxicity.
Jiang JJ, Zhang GF, Zheng JY, Sun JH, Ding SB
Frontiers in pharmacology 2022;13:876550
Frontiers in pharmacology 2022;13:876550
Silenced LINC01134 Enhances Oxaliplatin Sensitivity by Facilitating Ferroptosis Through GPX4 in Hepatocarcinoma.
Kang X, Huo Y, Jia S, He F, Li H, Zhou Q, Chang N, Liu D, Li R, Hu Y, Zhang P, Xu A
Frontiers in oncology 2022;12:939605
Frontiers in oncology 2022;12:939605
Glutathione Peroxidase 4 as a Therapeutic Target for Anti-Colorectal Cancer Drug-Tolerant Persister Cells.
Zhang X, Ma Y, Ma J, Yang L, Song Q, Wang H, Lv G
Frontiers in oncology 2022;12:913669
Frontiers in oncology 2022;12:913669
Designer Exosomes for Targeted Delivery of a Novel Therapeutic Cargo to Enhance Sorafenib-Mediated Ferroptosis in Hepatocellular Carcinoma.
Li X, Yu Q, Zhao R, Guo X, Liu C, Zhang K, Zhang W, Liu J, Yu J, Wang S, Hao Q, Li W, Zhang W, Li M, Zhang Y, Zhang C, Gao Y
Frontiers in oncology 2022;12:898156
Frontiers in oncology 2022;12:898156
FNDC5 Causes Resistance to Sorafenib by Activating the PI3K/Akt/Nrf2 Pathway in Hepatocellular Carcinoma Cells.
Liu H, Zhao L, Wang M, Yang K, Jin Z, Zhao C, Shi G
Frontiers in oncology 2022;12:852095
Frontiers in oncology 2022;12:852095
PLA2G6 Silencing Suppresses Melanoma Progression and Affects Ferroptosis Revealed by Quantitative Proteomics.
Wang Y, Song H, Miao Q, Wang Y, Qi J, Xu X, Sun J
Frontiers in oncology 2022;12:819235
Frontiers in oncology 2022;12:819235
UFL1 alleviates ER stress and apoptosis stimulated by LPS via blocking the ferroptosis pathway in human granulosa-like cells.
Li J, Tang X, Tu X, Jin Z, Dong H, Yang Q, Yao T, Pan Z
Cell stress & chaperones 2022 Sep;27(5):485-497
Cell stress & chaperones 2022 Sep;27(5):485-497
Iron overload promotes intervertebral disc degeneration via inducing oxidative stress and ferroptosis in endplate chondrocytes.
Wang W, Jing X, Du T, Ren J, Liu X, Chen F, Shao Y, Sun S, Yang G, Cui X
Free radical biology & medicine 2022 Sep;190:234-246
Free radical biology & medicine 2022 Sep;190:234-246
Hedyotis diffusa injection induces ferroptosis via the Bax/Bcl2/VDAC2/3 axis in lung adenocarcinoma.
Huang F, Pang J, Xu L, Niu W, Zhang Y, Li S, Li X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Sep;104:154319
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Sep;104:154319
Dexmedetomidine prevents hemorrhagic brain injury by reducing damage induced by ferroptosis in mice.
Liu MJ, Zhao XC, Gong HS, You YQ, Li JY
Neuroscience letters 2022 Sep 25;788:136842
Neuroscience letters 2022 Sep 25;788:136842
Gastrodin Ameliorates Cognitive Dysfunction in Vascular Dementia Rats by Suppressing Ferroptosis via the Regulation of the Nrf2/Keap1-GPx4 Signaling Pathway.
Li Y, Zhang E, Yang H, Chen Y, Tao L, Xu Y, Chen T, Shen X
Molecules (Basel, Switzerland) 2022 Sep 24;27(19)
Molecules (Basel, Switzerland) 2022 Sep 24;27(19)
IDH1 Promotes Foam Cell Formation by Aggravating Macrophage Ferroptosis.
Li B, Wang C, Lu P, Ji Y, Wang X, Liu C, Lu X, Xu X, Wang X
Biology 2022 Sep 23;11(10)
Biology 2022 Sep 23;11(10)
Elaiophylin triggers paraptosis and preferentially kills ovarian cancer drug-resistant cells by inducing MAPK hyperactivation.
Li GN, Zhao XJ, Wang Z, Luo MS, Shi SN, Yan DM, Li HY, Liu JH, Yang Y, Tan JH, Zhang ZY, Chen RQ, Lai HL, Huang XY, Zhou JF, Ma D, Fang Y, Gao QL
Signal transduction and targeted therapy 2022 Sep 12;7(1):317
Signal transduction and targeted therapy 2022 Sep 12;7(1):317
MCTR1 inhibits ferroptosis by promoting NRF2 expression to attenuate hepatic ischemia-reperfusion injury.
Ye J, Peng J, Liu K, Zhang T, Huang W
American journal of physiology. Gastrointestinal and liver physiology 2022 Sep 1;323(3):G283-G293
American journal of physiology. Gastrointestinal and liver physiology 2022 Sep 1;323(3):G283-G293
New Deferric Amine Compounds Efficiently Chelate Excess Iron to Treat Iron Overload Disorders and to Prevent Ferroptosis.
Feng W, Xiao Y, Zhao C, Zhang Z, Liu W, Ma J, Ganz T, Zhang J, Liu S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Oct;9(29):e2202679
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Oct;9(29):e2202679
Hydrogen Peroxide Promotes the Production of Radiation-Derived EVs Containing Mitochondrial Proteins.
Miller CE, Xu F, Zhao Y, Luo W, Zhong W, Meyer K, Jayswal R, Weiss HL, St Clair WH, St Clair DK, Chaiswing L
Antioxidants (Basel, Switzerland) 2022 Oct 27;11(11)
Antioxidants (Basel, Switzerland) 2022 Oct 27;11(11)
Matrix stiffness-dependent STEAP3 coordinated with PD-L2 identify tumor responding to sorafenib treatment in hepatocellular carcinoma.
Wang S, Chen L, Liu W
Cancer cell international 2022 Oct 13;22(1):318
Cancer cell international 2022 Oct 13;22(1):318
Identification of FDFT1 as a potential biomarker associated with ferroptosis in ccRCC.
Huang R, Zhang C, Wang X, Zou X, Xiang Z, Wang Z, Gui B, Lin T, Hu H
Cancer medicine 2022 Nov;11(21):3993-4004
Cancer medicine 2022 Nov;11(21):3993-4004
Cadmium induces ferroptosis mediated inflammation by activating Gpx4/Ager/p65 axis in pancreatic β-cells.
Hong H, Lin X, Xu Y, Tong T, Zhang J, He H, Yang L, Lu Y, Zhou Z
The Science of the total environment 2022 Nov 25;849:157819
The Science of the total environment 2022 Nov 25;849:157819
Sirtuin 7 mitigates renal ferroptosis, fibrosis and injury in hypertensive mice by facilitating the KLF15/Nrf2 signaling.
Li XT, Song JW, Zhang ZZ, Zhang MW, Liang LR, Miao R, Liu Y, Chen YH, Liu XY, Zhong JC
Free radical biology & medicine 2022 Nov 20;193(Pt 1):459-473
Free radical biology & medicine 2022 Nov 20;193(Pt 1):459-473
Validation of MAPK signalling pathway as a key role of paeoniflorin in the treatment of intrahepatic cholestasis of pregnancy based on network pharmacology and metabolomics.
Wang J, Wen J, Ma X, Yang J, Zhang Z, Xie S, Wei S, Jing M, Li H, Lang L, Zhou X, Zhao Y
European journal of pharmacology 2022 Nov 15;935:175331
European journal of pharmacology 2022 Nov 15;935:175331
A multi-target directed ligands strategy for the treatment of Alzheimer's disease: Dimethyl fumarate plus Tranilast modified Dithiocarbate as AChE inhibitor and Nrf2 activator.
Guo J, Cheng M, Liu P, Cao D, Luo J, Wan Y, Fang Y, Jin Y, Xie SS, Liu J
European journal of medicinal chemistry 2022 Nov 15;242:114630
European journal of medicinal chemistry 2022 Nov 15;242:114630
Identification of GPX4 as a therapeutic target for lung adenocarcinoma after EGFR-TKI resistance.
Zhang C, Wang C, Yang Z, Bai Y, Shukuya T, Poh ME, Ekman S, Li J, Xu Y, Deng S
Translational lung cancer research 2022 May;11(5):786-801
Translational lung cancer research 2022 May;11(5):786-801
β-amyloid protein induces mitophagy-dependent ferroptosis through the CD36/PINK/PARKIN pathway leading to blood-brain barrier destruction in Alzheimer's disease.
Li J, Li M, Ge Y, Chen J, Ma J, Wang C, Sun M, Wang L, Yao S, Yao C
Cell & bioscience 2022 May 26;12(1):69
Cell & bioscience 2022 May 26;12(1):69
Ferritinophagy is Involved in Experimental Subarachnoid Hemorrhage-Induced Neuronal Ferroptosis.
Liang Y, Deng Y, Zhao J, Liu L, Wang J, Chen P, Zhang Q, Sun C, Wang Y, Xiang Y, He Z
Neurochemical research 2022 Mar;47(3):692-700
Neurochemical research 2022 Mar;47(3):692-700
Elabela alleviates ferroptosis, myocardial remodeling, fibrosis and heart dysfunction in hypertensive mice by modulating the IL-6/STAT3/GPX4 signaling.
Zhang Z, Tang J, Song J, Xie M, Liu Y, Dong Z, Liu X, Li X, Zhang M, Chen Y, Shi H, Zhong J
Free radical biology & medicine 2022 Mar;181:130-142
Free radical biology & medicine 2022 Mar;181:130-142
Obacunone alleviates ferroptosis during lipopolysaccharide-induced acute lung injury by upregulating Nrf2-dependent antioxidant responses.
Li J, Deng SH, Li J, Li L, Zhang F, Zou Y, Wu DM, Xu Y
Cellular & molecular biology letters 2022 Mar 19;27(1):29
Cellular & molecular biology letters 2022 Mar 19;27(1):29
SSBP1 drives high fructose-induced glomerular podocyte ferroptosis via activating DNA-PK/p53 pathway.
Wu WY, Wang ZX, Li TS, Ding XQ, Liu ZH, Yang J, Fang L, Kong LD
Redox biology 2022 Jun;52:102303
Redox biology 2022 Jun;52:102303
Notch3 regulates ferroptosis via ROS-induced lipid peroxidation in NSCLC cells.
Li Z, Xiao J, Liu M, Cui J, Lian B, Sun Y, Li C
FEBS open bio 2022 Jun;12(6):1197-1205
FEBS open bio 2022 Jun;12(6):1197-1205
Metformin alleviates osteoarthritis in mice by inhibiting chondrocyte ferroptosis and improving subchondral osteosclerosis and angiogenesis.
Yan J, Feng G, Ma L, Chen Z, Jin Q
Journal of orthopaedic surgery and research 2022 Jun 28;17(1):333
Journal of orthopaedic surgery and research 2022 Jun 28;17(1):333
Puerarin Attenuates Oxidative Stress and Ferroptosis via AMPK/PGC1α/Nrf2 Pathway after Subarachnoid Hemorrhage in Rats.
Huang Y, Wu H, Hu Y, Zhou C, Wu J, Wu Y, Wang H, Lenahan C, Huang L, Nie S, Gao X, Sun J
Antioxidants (Basel, Switzerland) 2022 Jun 27;11(7)
Antioxidants (Basel, Switzerland) 2022 Jun 27;11(7)
Inhibition of AKT induces p53/SIRT6/PARP1-dependent parthanatos to suppress tumor growth.
Zhang Y, Zhang C, Li J, Jiang M, Guo S, Yang G, Zhang L, Wang F, Yi S, Wang J, Fu Y, Zhang Y
Cell communication and signaling : CCS 2022 Jun 17;20(1):93
Cell communication and signaling : CCS 2022 Jun 17;20(1):93
Role of ferroptosis-related genes in coronary atherosclerosis and identification of key genes: integration of bioinformatics analysis and experimental validation.
Meng Q, Xu Y, Ling X, Liu H, Ding S, Wu H, Yan D, Fang X, Li T, Liu Q
BMC cardiovascular disorders 2022 Jul 29;22(1):339
BMC cardiovascular disorders 2022 Jul 29;22(1):339
Seco-Lupane Triterpene Derivatives Induce Ferroptosis through GPX4/ACSL4 Axis and Target Cyclin D1 to Block the Cell Cycle.
Wang H, Wu D, Gao C, Teng H, Zhao Y, He Z, Chen W, Zong Y, Du R
Journal of medicinal chemistry 2022 Jul 28;65(14):10014-10044
Journal of medicinal chemistry 2022 Jul 28;65(14):10014-10044
Glutathione-depleting polymer delivering chlorin e6 for enhancing photodynamic therapy.
Wang SY, Chen G, Chen JF, Wang J, Deng SH, Cheng D
RSC advances 2022 Jul 21;12(33):21609-21620
RSC advances 2022 Jul 21;12(33):21609-21620
TFRC upregulation promotes ferroptosis in CVB3 infection via nucleus recruitment of Sp1.
Yi L, Hu Y, Wu Z, Li Y, Kong M, Kang Z, Zuoyuan B, Yang Z
Cell death & disease 2022 Jul 11;13(7):592
Cell death & disease 2022 Jul 11;13(7):592
Dihydroartemisinin enhances the inhibitory effect of sorafenib on HepG2 cells by inducing ferroptosis and inhibiting energy metabolism.
Cui Z, Wang H, Li S, Qin T, Shi H, Ma J, Li L, Yu G, Jiang T, Li C
Journal of pharmacological sciences 2022 Jan;148(1):73-85
Journal of pharmacological sciences 2022 Jan;148(1):73-85
Effects of butein on human osteosarcoma cell proliferation, apoptosis, and autophagy through oxidative stress.
Zhang P, Zhang J, Quan H, Chen P, Wang J, Liang Y
Human & experimental toxicology 2022 Jan-Dec;41:9603271221074346
Human & experimental toxicology 2022 Jan-Dec;41:9603271221074346
Insamgobonhwan Protects Neuronal Cells from Lipid ROS and Improves Deficient Cognitive Function.
Yang JH, Nguyen CD, Lee G, Na CS
Antioxidants (Basel, Switzerland) 2022 Jan 31;11(2)
Antioxidants (Basel, Switzerland) 2022 Jan 31;11(2)
APR-246 induces early cell death by ferroptosis in acute myeloid leukemia.
Birsen R, Larrue C, Decroocq J, Johnson N, Guiraud N, Gotanegre M, Cantero-Aguilar L, Grignano E, Huynh T, Fontenay M, Kosmider O, Mayeux P, Chapuis N, Sarry JE, Tamburini J, Bouscary D
Haematologica 2022 Feb 1;107(2):403-416
Haematologica 2022 Feb 1;107(2):403-416
A biomimetic nanodrug self-assembled from small molecules for enhanced ferroptosis therapy.
Xu X, Chen Y, Gui J, Liu P, Huang Y, Shao B, Ping Y, Li B
Biomaterials science 2022 Feb 1;10(3):770-780
Biomaterials science 2022 Feb 1;10(3):770-780
Ferroptosis as a mechanism of oligodendrocyte loss and demyelination in experimental autoimmune encephalomyelitis.
Li X, Chu Y, Ma R, Dou M, Li S, Song Y, Lv Y, Zhu L
Journal of neuroimmunology 2022 Dec 15;373:577995
Journal of neuroimmunology 2022 Dec 15;373:577995
RSL3 triggers glioma stem cell differentiation via the Tgm2/AKT/ID1 signaling axis.
Li M, Song D, Chen X, Wang X, Xu L, Yang M, Yang J, Kalvakolanu DV, Wei X, Liu X, Li Y, Guo B, Zhang L
Biochimica et biophysica acta. Molecular basis of disease 2022 Dec 1;1868(12):166529
Biochimica et biophysica acta. Molecular basis of disease 2022 Dec 1;1868(12):166529
Liproxstatin-1 alleviates LPS/IL-13-induced bronchial epithelial cell injury and neutrophilic asthma in mice by inhibiting ferroptosis.
Bao C, Liu C, Liu Q, Hua L, Hu J, Li Z, Xu S
International immunopharmacology 2022 Aug;109:108770
International immunopharmacology 2022 Aug;109:108770
The mechanism of the imbalance between proliferation and ferroptosis in pulmonary artery smooth muscle cells based on the activation of SLC7A11.
Hu P, Xu Y, Jiang Y, Huang J, Liu Y, Wang D, Tao T, Sun Z, Liu Y
European journal of pharmacology 2022 Aug 5;928:175093
European journal of pharmacology 2022 Aug 5;928:175093
Comprehensive analysis of placental gene-expression profiles and identification of EGFR-mediated autophagy and ferroptosis suppression in intrahepatic cholestasis of pregnancy.
Fang Y, Fang D
Gene 2022 Aug 5;834:146594
Gene 2022 Aug 5;834:146594
Inhibition of the PIN1-NRF2/GPX4 axis imparts sensitivity to cisplatin in cervical cancer cells.
Zhang Z, Hu Q, Ye S, Xiang L
Acta biochimica et biophysica Sinica 2022 Aug 25;54(9):1325-1335
Acta biochimica et biophysica Sinica 2022 Aug 25;54(9):1325-1335
Maresin1 Suppresses High-Glucose-Induced Ferroptosis in Osteoblasts via NRF2 Activation in Type 2 Diabetic Osteoporosis.
Zhang Z, Ji C, Wang YN, Liu S, Wang M, Xu X, Zhang D
Cells 2022 Aug 17;11(16)
Cells 2022 Aug 17;11(16)
GPX4 suppresses ferroptosis to promote malignant progression of endometrial carcinoma via transcriptional activation by ELK1.
Wei S, Yu Z, Shi R, An L, Zhang Q, Zhang Q, Zhang T, Zhang J, Wang H
BMC cancer 2022 Aug 12;22(1):881
BMC cancer 2022 Aug 12;22(1):881
Melatonin ameliorates diabetic hyperglycaemia-induced impairment of Leydig cell steroidogenic function through activation of SIRT1 pathway.
Wang P, Zhang S, Lin S, Lv Z
Reproductive biology and endocrinology : RB&E 2022 Aug 12;20(1):117
Reproductive biology and endocrinology : RB&E 2022 Aug 12;20(1):117
Phyto-sesquiterpene lactones DET and DETD-35 induce ferroptosis in vemurafenib sensitive and resistant melanoma via GPX4 inhibition and metabolic reprogramming.
Chang MT, Tsai LC, Nakagawa-Goto K, Lee KH, Shyur LF
Pharmacological research 2022 Apr;178:106148
Pharmacological research 2022 Apr;178:106148
Dexamethasone induces ferroptosis via P53/SLC7A11/GPX4 pathway in glucocorticoid-induced osteonecrosis of the femoral head.
Sun F, Zhou JL, Liu ZL, Jiang ZW, Peng H
Biochemical and biophysical research communications 2022 Apr 30;602:149-155
Biochemical and biophysical research communications 2022 Apr 30;602:149-155
Silencing of lncRNA MALAT1 facilitates erastin-induced ferroptosis in endometriosis through miR-145-5p/MUC1 signaling.
Liang Z, Wu Q, Wang H, Tan J, Wang H, Gou Y, Cao Y, Li Z, Zhang Z
Cell death discovery 2022 Apr 11;8(1):190
Cell death discovery 2022 Apr 11;8(1):190
Ferritinophagy-Mediated ROS Production Contributed to Proliferation Inhibition, Apoptosis, and Ferroptosis Induction in Action of Mechanism of 2-Pyridylhydrazone Dithiocarbamate Acetate.
Li L, Li H, Li Y, Feng J, Guan D, Zhang Y, Fu Y, Li S, Li C
Oxidative medicine and cellular longevity 2021;2021:5594059
Oxidative medicine and cellular longevity 2021;2021:5594059
Ferritinophagic Flux Was a Driving Force in Determination of Status of EMT, Ferroptosis, and NDRG1 Activation in Action of Mechanism of 2-Pyridylhydrazone Dithiocarbamate S-Acetic Acid.
Li H, Zhou W, Wei H, Li L, Wang X, Li Y, Li S, Li C
Journal of oncology 2021;2021:3015710
Journal of oncology 2021;2021:3015710
Calorie Restriction Protects against Contrast-Induced Nephropathy via SIRT1/GPX4 Activation.
Fang D, Wang Y, Zhang Z, Yang D, Gu D, He B, Zhang X, He D, Wang H, Jose PA, Han Y, Zeng C
Oxidative medicine and cellular longevity 2021;2021:2999296
Oxidative medicine and cellular longevity 2021;2021:2999296
Mesenchymal Stem Cells Alleviate Post-resuscitation Cardiac and Cerebral Injuries by Inhibiting Cell Pyroptosis and Ferroptosis in a Swine Model of Cardiac Arrest.
Xu J, Zhang M, Liu F, Shi L, Jiang X, Chen C, Wang J, Diao M, Khan ZU, Zhang M
Frontiers in pharmacology 2021;12:793829
Frontiers in pharmacology 2021;12:793829
Characterization of Interplay Between Autophagy and Ferroptosis and Their Synergistical Roles on Manipulating Immunological Tumor Microenvironment in Squamous Cell Carcinomas.
Chen L, Niu X, Qiao X, Liu S, Ma H, Shi X, He X, Zhong M
Frontiers in immunology 2021;12:739039
Frontiers in immunology 2021;12:739039
Inhibition of DNMT-1 alleviates ferroptosis through NCOA4 mediated ferritinophagy during diabetes myocardial ischemia/reperfusion injury.
Li W, Li W, Wang Y, Leng Y, Xia Z
Cell death discovery 2021 Sep 29;7(1):267
Cell death discovery 2021 Sep 29;7(1):267
Activation of NRF2/FPN1 pathway attenuates myocardial ischemia-reperfusion injury in diabetic rats by regulating iron homeostasis and ferroptosis.
Tian H, Xiong Y, Zhang Y, Leng Y, Tao J, Li L, Qiu Z, Xia Z
Cell stress & chaperones 2021 Mar;27(2):149-164
Cell stress & chaperones 2021 Mar;27(2):149-164
Lipoxin A4 protects primary spinal cord neurons from Erastin-induced ferroptosis by activating the Akt/Nrf2/HO-1 signaling pathway.
Wei N, Lu T, Yang L, Dong Y, Liu X
FEBS open bio 2021 Aug;11(8):2118-2126
FEBS open bio 2021 Aug;11(8):2118-2126
Knockdown of Trnau1ap inhibits the proliferation and migration of NIH3T3, JEG-3 and Bewo cells via the PI3K/Akt signaling pathway.
Hu X, Luo J, Lai H, Li M, Zheng X, Nie T, Li F, Li H
Biochemical and biophysical research communications 2018 Sep 5;503(2):521-527
Biochemical and biophysical research communications 2018 Sep 5;503(2):521-527
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