Antibody data
- Antibody Data
- Antigen structure
- References [36]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
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Validation data
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- Product number
- 14432-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14432-1-AP, RRID:AB_10898356
- Product name
- GPX4 antibody
- Antibody type
- Polyclonal
- Description
- GPX4 antibody (Cat. #14432-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Oxalate Activates Autophagy to Induce Ferroptosis of Renal Tubular Epithelial Cells and Participates in the Formation of Kidney Stones.
Ulinastatin protects against acetaminophen-induced liver injury by alleviating ferroptosis via the SIRT1/NRF2/HO-1 pathway.
Comprehensive Analysis of the Tumor Microenvironment and Ferroptosis-Related Genes Predict Prognosis with Ovarian Cancer.
Lidocaine Promoted Ferroptosis by Targeting miR-382-5p /SLC7A11 Axis in Ovarian and Breast Cancer.
HIF-1-induced mitochondrial ribosome protein L52: a mechanism for breast cancer cellular adaptation and metastatic initiation in response to hypoxia.
Proteome Analysis of Camellia nitidissima Chi Revealed Its Role in Colon Cancer Through the Apoptosis and Ferroptosis Pathway.
Role of ferroptosis in cisplatin-induced acute nephrotoxicity in mice.
Atractylodin may induce ferroptosis of human hepatocellular carcinoma cells.
Cadmium attenuates testosterone synthesis by promoting ferroptosis and blocking autophagosome-lysosome fusion.
Loss of ferroportin induces memory impairment by promoting ferroptosis in Alzheimer's disease.
Combination of ponatinib with deferoxamine synergistically mitigates ischemic heart injury via simultaneous prevention of necroptosis and ferroptosis.
Guizhi Fuling Capsule ameliorates endometrial hyperplasia through promoting p62-Keap1-NRF2-mediated ferroptosis.
Dihydroisotanshinone I induced ferroptosis and apoptosis of lung cancer cells.
SIRT1-autophagy axis inhibits excess iron-induced ferroptosis of foam cells and subsequently increases IL-1Β and IL-18.
Effects of Loblolly Pine Biochar and Wood Vinegar on Poultry Litter Nutrients and Microbial Abundance.
Role of ferroptosis induced by a high concentration of calcium oxalate in the formation and development of urolithiasis.
Targeted inhibition of Rev-erb-α/β limits ferroptosis to ameliorate folic acid-induced acute kidney injury.
Obacunone Attenuates Liver Fibrosis with Enhancing Anti-Oxidant Effects of GPx-4 and Inhibition of EMT.
Iron deposition-induced ferroptosis in alveolar type II cells promotes the development of pulmonary fibrosis.
miR-324-3p reverses cisplatin resistance by inducing GPX4-mediated ferroptosis in lung adenocarcinoma cell line A549.
IMCA Induces Ferroptosis Mediated by SLC7A11 through the AMPK/mTOR Pathway in Colorectal Cancer.
Mitochondrial Iron Overload-Mediated Inhibition of Nrf2-HO-1/GPX4 Assisted ALI-Induced Nephrotoxicity.
Fasting Drives Nrf2-Related Antioxidant Response in Skeletal Muscle.
Pyroptosis and ferroptosis induced by mixed lineage kinase 3 (MLK3) signaling in cardiomyocytes are essential for myocardial fibrosis in response to pressure overload.
Ferroptosis inhibitor alleviates Radiation-induced lung fibrosis (RILF) via down-regulation of TGF-β1.
Catalpol Exerts a Neuroprotective Effect in the MPTP Mouse Model of Parkinson's Disease.
Danshen Improves Survival of Patients With Breast Cancer and Dihydroisotanshinone I Induces Ferroptosis and Apoptosis of Breast Cancer Cells.
Role of ferroptosis in the process of acute radiation-induced lung injury in mice.
Adipose-Specific Lipin-1 Overexpression Renders Hepatic Ferroptosis and Exacerbates Alcoholic Steatohepatitis in Mice.
Insulin-like growth factor II receptor-α is a novel stress-inducible contributor to cardiac damage underpinning doxorubicin-induced oxidative stress and perturbed mitochondrial autophagy.
Effects of autophagy on the spermatogonia of chronic hypoxic mice.
Choroid plexus glutathione peroxidases are instrumental in protecting the brain fluid environment from hydroperoxides during postnatal development.
Mitochondria-targeted antioxidant SkQ1 improves spermatogenesis in Immp2l mutant mice.
Selenium-sensitive miRNA-181a-5p targeting SBP2 regulates selenoproteins expression in cartilage.
Glutathione maintenance mitigates age-related susceptibility to redox cycling agents.
Alteration of sperm protein profile induced by cigarette smoking.
Song Q, Liao W, Chen X, He Z, Li, Li B, Liu J, Liu L, Xiong Y, Song C, Yang S
Oxidative medicine and cellular longevity 2021;2021:6630343
Oxidative medicine and cellular longevity 2021;2021:6630343
Ulinastatin protects against acetaminophen-induced liver injury by alleviating ferroptosis via the SIRT1/NRF2/HO-1 pathway.
Wang C, Liu T, Tong Y, Cui R, Qu K, Liu C, Zhang J
American journal of translational research 2021;13(6):6031-6042
American journal of translational research 2021;13(6):6031-6042
Comprehensive Analysis of the Tumor Microenvironment and Ferroptosis-Related Genes Predict Prognosis with Ovarian Cancer.
Li XX, Xiong L, Wen Y, Zhang ZJ
Frontiers in genetics 2021;12:774400
Frontiers in genetics 2021;12:774400
Lidocaine Promoted Ferroptosis by Targeting miR-382-5p /SLC7A11 Axis in Ovarian and Breast Cancer.
Sun D, Li YC, Zhang XY
Frontiers in pharmacology 2021;12:681223
Frontiers in pharmacology 2021;12:681223
HIF-1-induced mitochondrial ribosome protein L52: a mechanism for breast cancer cellular adaptation and metastatic initiation in response to hypoxia.
Li X, Wang M, Li S, Chen Y, Wang M, Wu Z, Sun X, Yao L, Dong H, Song Y, Xu Y
Theranostics 2021;11(15):7337-7359
Theranostics 2021;11(15):7337-7359
Proteome Analysis of Camellia nitidissima Chi Revealed Its Role in Colon Cancer Through the Apoptosis and Ferroptosis Pathway.
Chen Y, Zhang F, Du Z, Xie J, Xia L, Hou X, Hao E, Deng J
Frontiers in oncology 2021;11:727130
Frontiers in oncology 2021;11:727130
Role of ferroptosis in cisplatin-induced acute nephrotoxicity in mice.
Ikeda Y, Hamano H, Horinouchi Y, Miyamoto L, Hirayama T, Nagasawa H, Tamaki T, Tsuchiya K
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 2021 Sep;67:126798
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 2021 Sep;67:126798
Atractylodin may induce ferroptosis of human hepatocellular carcinoma cells.
He Y, Fang D, Liang T, Pang H, Nong Y, Tang L, Yang Z, Lu C, Han X, Zhao S, Mo S, Meng Y, Han C, Peng T
Annals of translational medicine 2021 Oct;9(20):1535
Annals of translational medicine 2021 Oct;9(20):1535
Cadmium attenuates testosterone synthesis by promoting ferroptosis and blocking autophagosome-lysosome fusion.
Zeng L, Zhou J, Wang X, Zhang Y, Wang M, Su P
Free radical biology & medicine 2021 Nov 20;176:176-188
Free radical biology & medicine 2021 Nov 20;176:176-188
Loss of ferroportin induces memory impairment by promoting ferroptosis in Alzheimer's disease.
Bao WD, Pang P, Zhou XT, Hu F, Xiong W, Chen K, Wang J, Wang F, Xie D, Hu YZ, Han ZT, Zhang HH, Wang WX, Nelson PT, Chen JG, Lu Y, Man HY, Liu D, Zhu LQ
Cell death and differentiation 2021 May;28(5):1548-1562
Cell death and differentiation 2021 May;28(5):1548-1562
Combination of ponatinib with deferoxamine synergistically mitigates ischemic heart injury via simultaneous prevention of necroptosis and ferroptosis.
Tu H, Zhou YJ, Tang LJ, Xiong XM, Zhang XJ, Ali Sheikh MS, Zhang JJ, Luo XJ, Yuan C, Peng J
European journal of pharmacology 2021 May 5;898:173999
European journal of pharmacology 2021 May 5;898:173999
Guizhi Fuling Capsule ameliorates endometrial hyperplasia through promoting p62-Keap1-NRF2-mediated ferroptosis.
Zhang M, Zhang T, Song C, Qu J, Gu Y, Liu S, Li H, Xiao W, Kong L, Sun Y, Lv W
Journal of ethnopharmacology 2021 Jun 28;274:114064
Journal of ethnopharmacology 2021 Jun 28;274:114064
Dihydroisotanshinone I induced ferroptosis and apoptosis of lung cancer cells.
Wu CY, Yang YH, Lin YS, Chang GH, Tsai MS, Hsu CM, Yeh RA, Shu LH, Cheng YC, Liu HT
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jul;139:111585
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jul;139:111585
SIRT1-autophagy axis inhibits excess iron-induced ferroptosis of foam cells and subsequently increases IL-1Β and IL-18.
Su G, Yang W, Wang S, Geng C, Guan X
Biochemical and biophysical research communications 2021 Jul 5;561:33-39
Biochemical and biophysical research communications 2021 Jul 5;561:33-39
Effects of Loblolly Pine Biochar and Wood Vinegar on Poultry Litter Nutrients and Microbial Abundance.
Mohammadi-Aragh MK, Stokes CE, Street JT, Linhoss JE
Animals : an open access journal from MDPI 2021 Jul 26;11(8)
Animals : an open access journal from MDPI 2021 Jul 26;11(8)
Role of ferroptosis induced by a high concentration of calcium oxalate in the formation and development of urolithiasis.
He Z, Liao W, Song Q, Li B, Liu J, Xiong Y, Song C, Yang S
International journal of molecular medicine 2021 Jan;47(1):289-301
International journal of molecular medicine 2021 Jan;47(1):289-301
Targeted inhibition of Rev-erb-α/β limits ferroptosis to ameliorate folic acid-induced acute kidney injury.
Guo L, Zhang T, Wang F, Chen X, Xu H, Zhou C, Chen M, Yu F, Wang S, Yang D, Wu B
British journal of pharmacology 2021 Jan;178(2):328-345
British journal of pharmacology 2021 Jan;178(2):328-345
Obacunone Attenuates Liver Fibrosis with Enhancing Anti-Oxidant Effects of GPx-4 and Inhibition of EMT.
Bai Y, Wang W, Wang L, Ma L, Zhai D, Wang F, Shi R, Liu C, Xu Q, Chen G, Lu Z
Molecules (Basel, Switzerland) 2021 Jan 9;26(2)
Molecules (Basel, Switzerland) 2021 Jan 9;26(2)
Iron deposition-induced ferroptosis in alveolar type II cells promotes the development of pulmonary fibrosis.
Cheng H, Feng D, Li X, Gao L, Tang S, Liu W, Wu X, Yue S, Li C, Luo Z
Biochimica et biophysica acta. Molecular basis of disease 2021 Dec 1;1867(12):166204
Biochimica et biophysica acta. Molecular basis of disease 2021 Dec 1;1867(12):166204
miR-324-3p reverses cisplatin resistance by inducing GPX4-mediated ferroptosis in lung adenocarcinoma cell line A549.
Deng SH, Wu DM, Li L, Liu T, Zhang T, Li J, Yu Y, He M, Zhao YY, Han R, Xu Y
Biochemical and biophysical research communications 2021 Apr 16;549:54-60
Biochemical and biophysical research communications 2021 Apr 16;549:54-60
IMCA Induces Ferroptosis Mediated by SLC7A11 through the AMPK/mTOR Pathway in Colorectal Cancer.
Zhang L, Liu W, Liu F, Wang Q, Song M, Yu Q, Tang K, Teng T, Wu D, Wang X, Han W, Li Y
Oxidative medicine and cellular longevity 2020;2020:1675613
Oxidative medicine and cellular longevity 2020;2020:1675613
Mitochondrial Iron Overload-Mediated Inhibition of Nrf2-HO-1/GPX4 Assisted ALI-Induced Nephrotoxicity.
Deng HF, Yue LX, Wang NN, Zhou YQ, Zhou W, Liu X, Ni YH, Huang CS, Qiu LZ, Liu H, Tan HL, Tang XL, Wang YG, Ma ZC, Gao Y
Frontiers in pharmacology 2020;11:624529
Frontiers in pharmacology 2020;11:624529
Fasting Drives Nrf2-Related Antioxidant Response in Skeletal Muscle.
Lettieri-Barbato D, Minopoli G, Caggiano R, Izzo R, Santillo M, Aquilano K, Faraonio R
International journal of molecular sciences 2020 Oct 21;21(20)
International journal of molecular sciences 2020 Oct 21;21(20)
Pyroptosis and ferroptosis induced by mixed lineage kinase 3 (MLK3) signaling in cardiomyocytes are essential for myocardial fibrosis in response to pressure overload.
Wang J, Deng B, Liu Q, Huang Y, Chen W, Li J, Zhou Z, Zhang L, Liang B, He J, Chen Z, Yan C, Yang Z, Xian S, Wang L
Cell death & disease 2020 Jul 24;11(7):574
Cell death & disease 2020 Jul 24;11(7):574
Ferroptosis inhibitor alleviates Radiation-induced lung fibrosis (RILF) via down-regulation of TGF-β1.
Li X, Duan L, Yuan S, Zhuang X, Qiao T, He J
Journal of inflammation (London, England) 2019;16:11
Journal of inflammation (London, England) 2019;16:11
Catalpol Exerts a Neuroprotective Effect in the MPTP Mouse Model of Parkinson's Disease.
Wang LY, Yu X, Li XX, Zhao YN, Wang CY, Wang ZY, He ZY
Frontiers in aging neuroscience 2019;11:316
Frontiers in aging neuroscience 2019;11:316
Danshen Improves Survival of Patients With Breast Cancer and Dihydroisotanshinone I Induces Ferroptosis and Apoptosis of Breast Cancer Cells.
Lin YS, Shen YC, Wu CY, Tsai YY, Yang YH, Lin YY, Kuan FC, Lu CN, Chang GH, Tsai MS, Hsu CM, Yeh RA, Yang PR, Lee IY, Shu LH, Cheng YC, Liu HT, Wu YH, Wu YH, Chang DC
Frontiers in pharmacology 2019;10:1226
Frontiers in pharmacology 2019;10:1226
Role of ferroptosis in the process of acute radiation-induced lung injury in mice.
Li X, Zhuang X, Qiao T
Biochemical and biophysical research communications 2019 Nov 5;519(2):240-245
Biochemical and biophysical research communications 2019 Nov 5;519(2):240-245
Adipose-Specific Lipin-1 Overexpression Renders Hepatic Ferroptosis and Exacerbates Alcoholic Steatohepatitis in Mice.
Zhou Z, Ye TJ, Bonavita G, Daniels M, Kainrad N, Jogasuria A, You M
Hepatology communications 2019 May;3(5):656-669
Hepatology communications 2019 May;3(5):656-669
Insulin-like growth factor II receptor-α is a novel stress-inducible contributor to cardiac damage underpinning doxorubicin-induced oxidative stress and perturbed mitochondrial autophagy.
Pandey S, Kuo WW, Shen CY, Yeh YL, Ho TJ, Chen RJ, Chang RL, Pai PY, Viswanadha VP, Huang CY, Huang CY
American journal of physiology. Cell physiology 2019 Aug 1;317(2):C235-C243
American journal of physiology. Cell physiology 2019 Aug 1;317(2):C235-C243
Effects of autophagy on the spermatogonia of chronic hypoxic mice.
Zhu S, Li W, Yang X, Yu W, Rao T, Ruan Y, Ning J, Yuan R, Li H, Jiang K, Li C, Cheng F
American journal of translational research 2018;10(12):4119-4129
American journal of translational research 2018;10(12):4119-4129
Choroid plexus glutathione peroxidases are instrumental in protecting the brain fluid environment from hydroperoxides during postnatal development.
Saudrais E, Strazielle N, Ghersi-Egea JF
American journal of physiology. Cell physiology 2018 Oct 1;315(4):C445-C456
American journal of physiology. Cell physiology 2018 Oct 1;315(4):C445-C456
Mitochondria-targeted antioxidant SkQ1 improves spermatogenesis in Immp2l mutant mice.
Jiang Y, Liu C, Lei B, Xu X, Lu B
Andrologia 2018 Mar;50(2)
Andrologia 2018 Mar;50(2)
Selenium-sensitive miRNA-181a-5p targeting SBP2 regulates selenoproteins expression in cartilage.
Min Z, Guo Y, Sun M, Hussain S, Zhao Y, Guo D, Huang H, Heng L, Zhang F, Ning Q, Han Y, Xu P, Zhong N, Sun J, Lu S
Journal of cellular and molecular medicine 2018 Dec;22(12):5888-5898
Journal of cellular and molecular medicine 2018 Dec;22(12):5888-5898
Glutathione maintenance mitigates age-related susceptibility to redox cycling agents.
Thomas NO, Shay KP, Kelley AR, Butler JA, Hagen TM
Redox biology 2016 Dec;10:45-52
Redox biology 2016 Dec;10:45-52
Alteration of sperm protein profile induced by cigarette smoking.
Chen X, Xu W, Miao M, Zhu Z, Dai J, Chen Z, Fang P, Wu J, Nie D, Wang L, Wang Z, Qiao Z, Shi H
Acta biochimica et biophysica Sinica 2015 Jul;47(7):504-15
Acta biochimica et biophysica Sinica 2015 Jul;47(7):504-15
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse kidney tissue were subjected to SDS PAGE followed by western blot with 14432-1-AP(GPX4 antibody) at dilution of 1:1000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human kidney using 14432-1-AP(GPX4 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The GPX4 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human GPX4. This antibody recognizes human,mouse,rat antigen. The GPX4 antibody has been validated for the following applications: ELISA, WB, IHC analysis.