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- Antibody Data
- Antigen structure
- References [21]
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- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [1]
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- Product number
- 11418-2-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11418-2-AP, RRID:AB_2245376
- Product name
- COX5B antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated COX5B antibody (Cat. #11418-2-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references The ISR downstream effector ATF4 promotes mGluR-dependent long-term depression and associated behavior.
Mitochondrial TRPV1 exacerbates cognitive deficits in sepsis-associated encephalopathy by driving microglial metabolic reprogramming.
Integrative Multi-Omics Analysis and Experiments Validation Identify COX5B as a Novel Therapeutic Target for Lung Adenocarcinoma.
HuMSCs-derived exosomal YBX1 participates in oxidative damage repair in granulosa cells by stabilizing COX5B mRNA in an m5C-dependent manner.
NDUFB9 ameliorates CUMS-induced depression-like behavior by promoting mitophagy.
Phosphorylation of POU3F3 Mediated Nuclear Translocation Promotes Proliferation in Non-Small Cell Lung Cancer through Accelerating ATP5PF Transcription and ATP Production.
Tumor cell-intrinsic epigenetic dysregulation shapes cancer-associated fibroblasts heterogeneity to metabolically support pancreatic cancer.
Adipocyte-Targeted Nanocomplex with Synergistic Photothermal and Pharmacological Effects for Combating Obesity and Related Metabolic Syndromes.
A cytosolic surveillance mechanism activates the mitochondrial UPR.
Protein and lipid expansion microscopy with trypsin and tyramide signal amplification for 3D imaging.
CK1δ and CK1ε Signaling Sustains Mitochondrial Metabolism and Cell Survival in Multiple Myeloma.
Glucose Starvation Inhibits Ferroptosis by Activating the LKB1/AMPK Signaling Pathway and Promotes the High Speed Linear Motility of Dairy Goat Sperm.
Global mitochondrial protein import proteomics reveal distinct regulation by translation and translocation machinery.
O-GlcNAcylation on Rab3A attenuates its effects on mitochondrial oxidative phosphorylation and metastasis in hepatocellular carcinoma.
The mitochondrial TMEM177 associates with COX20 during COX2 biogenesis.
Enhanced Respiratory Chain Supercomplex Formation in Response to Exercise in Human Skeletal Muscle.
Mitochondrial respiratory-chain adaptations in macrophages contribute to antibacterial host defense.
Mitochondrial Protein Synthesis Adapts to Influx of Nuclear-Encoded Protein.
Mechanism of super-assembly of respiratory complexes III and IV.
Analysis of the mitochondrial proteome in multiple sclerosis cortex.
Acquisition of temozolomide chemoresistance in gliomas leads to remodeling of mitochondrial electron transport chain.
Mahmood N, Dang CL, Wu PY, Huang Z, Choi JH, Psycharis K, Portugese R, Khoutorsky A, Costa-Mattioli M, McKinney RA, Sonenberg N
Proceedings of the National Academy of Sciences of the United States of America 2026 Feb 24;123(8):e2532796123
Proceedings of the National Academy of Sciences of the United States of America 2026 Feb 24;123(8):e2532796123
Mitochondrial TRPV1 exacerbates cognitive deficits in sepsis-associated encephalopathy by driving microglial metabolic reprogramming.
Fan Z, Du L, Yin L, Liu H, Li M, Li J, Liu F, Yang L, Li J, Wang Q, Wu Y, Ma H, Zhang X
Free radical biology & medicine 2026 Apr;247:448-468
Free radical biology & medicine 2026 Apr;247:448-468
Integrative Multi-Omics Analysis and Experiments Validation Identify COX5B as a Novel Therapeutic Target for Lung Adenocarcinoma.
Ling L, Lu M, Ye L, Chen Y, Lin S, Yang J, Rong Y, Wu G
Oncology research 2025;34(1):22
Oncology research 2025;34(1):22
HuMSCs-derived exosomal YBX1 participates in oxidative damage repair in granulosa cells by stabilizing COX5B mRNA in an m5C-dependent manner.
Zhu X, Lu M, Li WX, Lin L, Liu Y, Zhou J, Shang J, Shi X, Lu J, Xing J, Zhang M, Zhao S, Zhao D
International journal of biological macromolecules 2025 May;310(Pt 4):143288
International journal of biological macromolecules 2025 May;310(Pt 4):143288
NDUFB9 ameliorates CUMS-induced depression-like behavior by promoting mitophagy.
Sun Y, Li L, Yang X, Yin S, Xiao Z
Translational psychiatry 2025 Aug 18;15(1):292
Translational psychiatry 2025 Aug 18;15(1):292
Phosphorylation of POU3F3 Mediated Nuclear Translocation Promotes Proliferation in Non-Small Cell Lung Cancer through Accelerating ATP5PF Transcription and ATP Production.
Zeng QG, Li L, Chang T, Sun Y, Zheng B, Xue LN, Liu CL, Li XQ, Huang RT, Gu JX, An ZR, Yao HT, Zhou DY, Fan J, Dai Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(13):e2411503
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(13):e2411503
Tumor cell-intrinsic epigenetic dysregulation shapes cancer-associated fibroblasts heterogeneity to metabolically support pancreatic cancer.
Niu N, Shen X, Wang Z, Chen Y, Weng Y, Yu F, Tang Y, Lu P, Liu M, Wang L, Sun Y, Yang M, Shen B, Jin J, Lu Z, Jiang K, Shi Y, Xue J
Cancer cell 2024 May 13;42(5):869-884.e9
Cancer cell 2024 May 13;42(5):869-884.e9
Adipocyte-Targeted Nanocomplex with Synergistic Photothermal and Pharmacological Effects for Combating Obesity and Related Metabolic Syndromes.
Zhang Y, Zeng X, Wu F, Yang X, Che T, Zheng Y, Li J, Zhang Y, Zhang X, Wu Z
Nanomaterials (Basel, Switzerland) 2024 Aug 19;14(16)
Nanomaterials (Basel, Switzerland) 2024 Aug 19;14(16)
A cytosolic surveillance mechanism activates the mitochondrial UPR.
Sutandy FXR, Gößner I, Tascher G, Münch C
Nature 2023 Jun;618(7966):849-854
Nature 2023 Jun;618(7966):849-854
Protein and lipid expansion microscopy with trypsin and tyramide signal amplification for 3D imaging.
Wang UT, Tian X, Liou YH, Lee SP, Hu HT, Lu CH, Lin PT, Cheng YJ, Chen P, Chen BC
Scientific reports 2023 Dec 8;13(1):21922
Scientific reports 2023 Dec 8;13(1):21922
CK1δ and CK1ε Signaling Sustains Mitochondrial Metabolism and Cell Survival in Multiple Myeloma.
Burger KL, Fernandez MR, Meads MB, Sudalagunta P, Oliveira PS, Renatino Canevarolo R, Alugubelli RR, Tungsevik A, De Avila G, Silva M, Graeter AI, Dai HA, Vincelette ND, Prabhu A, Magaletti D, Yang C, Li W, Kulkarni A, Hampton O, Koomen JM, Roush WR, Monastyrskyi A, Berglund AE, Silva AS, Cleveland JL, Shain KH
Cancer research 2023 Dec 1;83(23):3901-3919
Cancer research 2023 Dec 1;83(23):3901-3919
Glucose Starvation Inhibits Ferroptosis by Activating the LKB1/AMPK Signaling Pathway and Promotes the High Speed Linear Motility of Dairy Goat Sperm.
Li Y, Zhang G, Wen F, Xian M, Guo S, Zhang X, Feng X, Hu Z, Hu J
Animals : an open access journal from MDPI 2023 Apr 23;13(9)
Animals : an open access journal from MDPI 2023 Apr 23;13(9)
Global mitochondrial protein import proteomics reveal distinct regulation by translation and translocation machinery.
Schäfer JA, Bozkurt S, Michaelis JB, Klann K, Münch C
Molecular cell 2022 Jan 20;82(2):435-446.e7
Molecular cell 2022 Jan 20;82(2):435-446.e7
O-GlcNAcylation on Rab3A attenuates its effects on mitochondrial oxidative phosphorylation and metastasis in hepatocellular carcinoma.
Wu W, Zheng X, Wang J, Yang T, Dai W, Song S, Fang L, Wang Y, Gu J
Cell death & disease 2018 Sep 20;9(10):970
Cell death & disease 2018 Sep 20;9(10):970
The mitochondrial TMEM177 associates with COX20 during COX2 biogenesis.
Lorenzi I, Oeljeklaus S, Aich A, Ronsör C, Callegari S, Dudek J, Warscheid B, Dennerlein S, Rehling P
Biochimica et biophysica acta. Molecular cell research 2018 Feb;1865(2):323-333
Biochimica et biophysica acta. Molecular cell research 2018 Feb;1865(2):323-333
Enhanced Respiratory Chain Supercomplex Formation in Response to Exercise in Human Skeletal Muscle.
Greggio C, Jha P, Kulkarni SS, Lagarrigue S, Broskey NT, Boutant M, Wang X, Conde Alonso S, Ofori E, Auwerx J, Cantó C, Amati F
Cell metabolism 2017 Feb 7;25(2):301-311
Cell metabolism 2017 Feb 7;25(2):301-311
Mitochondrial respiratory-chain adaptations in macrophages contribute to antibacterial host defense.
Garaude J, Acín-Pérez R, Martínez-Cano S, Enamorado M, Ugolini M, Nistal-Villán E, Hervás-Stubbs S, Pelegrín P, Sander LE, Enríquez JA, Sancho D
Nature immunology 2016 Sep;17(9):1037-1045
Nature immunology 2016 Sep;17(9):1037-1045
Mitochondrial Protein Synthesis Adapts to Influx of Nuclear-Encoded Protein.
Richter-Dennerlein R, Oeljeklaus S, Lorenzi I, Ronsör C, Bareth B, Schendzielorz AB, Wang C, Warscheid B, Rehling P, Dennerlein S
Cell 2016 Oct 6;167(2):471-483.e10
Cell 2016 Oct 6;167(2):471-483.e10
Mechanism of super-assembly of respiratory complexes III and IV.
Cogliati S, Calvo E, Loureiro M, Guaras AM, Nieto-Arellano R, Garcia-Poyatos C, Ezkurdia I, Mercader N, Vázquez J, Enriquez JA
Nature 2016 Nov 24;539(7630):579-582
Nature 2016 Nov 24;539(7630):579-582
Analysis of the mitochondrial proteome in multiple sclerosis cortex.
Broadwater L, Pandit A, Clements R, Azzam S, Vadnal J, Sulak M, Yong VW, Freeman EJ, Gregory RB, McDonough J
Biochimica et biophysica acta 2011 May;1812(5):630-41
Biochimica et biophysica acta 2011 May;1812(5):630-41
Acquisition of temozolomide chemoresistance in gliomas leads to remodeling of mitochondrial electron transport chain.
Oliva CR, Nozell SE, Diers A, McClugage SG 3rd, Sarkaria JN, Markert JM, Darley-Usmar VM, Bailey SM, Gillespie GY, Landar A, Griguer CE
The Journal of biological chemistry 2010 Dec 17;285(51):39759-67
The Journal of biological chemistry 2010 Dec 17;285(51):39759-67
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse liver tissue were subjected to SDS PAGE followed by western blot with 11418-2-AP(COX5B antibody) at dilution of 1:1000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of MCF-7 cells, using COX5B antibody 11418-2-AP at 1:50 antibody and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human gliomas using 11418-2-AP(COX5B antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
