Antibody data
- Antibody Data
- Antigen structure
- References [4]
- Comments [0]
- Validations
- Immunohistochemistry [1]
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- Product number
- 14-6604-80 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- Lactoferrin Monoclonal Antibody (B97), eBioscience™
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- Description: This B97 monoclonal antibody reacts with human lactoferrin. This 80-kDa glycoprotein is detectable in the kidney, lung, pancreas, gallbladder, prostate, seminal vesicle, gut, and liver. Lactoferrin is also present in mucosal secretions such as breast milk, tears, and saliva. In immune cells, high levels of lactoferrin can be found within the secondary granules of neutrophils, but not in lymphocytes or monocytes. A member of the transferrin family of proteins, lactoferrin binds two iron molecules to mediate its transport and storage. Lactoferrin plays an important role in host defense against pathogens and can regulate adaptive immune responses. Receptors for lactoferrin are present on the surface of lymphocytes, granulocytes, monocytes, mast cells, epithelial, and endothelial cells.
- Antibody clone number
- B97
- Concentration
- 0.5 mg/mL
Submitted references Lactoferrin as a natural immune modulator.
Identification of an alternative form of human lactoferrin mRNA that is expressed differentially in normal tissues and tumor-derived cell lines.
Immunoreactive lactoferrin in resting, activated, and neoplastic lymphocytes.
Lactoferrin--specific localization in the nuclei of human polymorphonuclear neutrophilic leukocytes.
Actor JK, Hwang SA, Kruzel ML
Current pharmaceutical design 2009;15(17):1956-73
Current pharmaceutical design 2009;15(17):1956-73
Identification of an alternative form of human lactoferrin mRNA that is expressed differentially in normal tissues and tumor-derived cell lines.
Siebert PD, Huang BC
Proceedings of the National Academy of Sciences of the United States of America 1997 Mar 18;94(6):2198-203
Proceedings of the National Academy of Sciences of the United States of America 1997 Mar 18;94(6):2198-203
Immunoreactive lactoferrin in resting, activated, and neoplastic lymphocytes.
Butler TW, Grossi CE, Canessa A, Pistoia V, Barton JC
Leukemia research 1990;14(5):441-7
Leukemia research 1990;14(5):441-7
Lactoferrin--specific localization in the nuclei of human polymorphonuclear neutrophilic leukocytes.
Green I, Kirkpatrick CH, Dale DC
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1971 Sep;137(4):1311-7
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1971 Sep;137(4):1311-7
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Supportive validation
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- Invitrogen Antibodies (provider)
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- Experimental details
- Immunohistochemistry on formalin-fixed paraffin embedded human infiltrating ductal carcinoma using 10 µg/mL of Mouse IgG1 k Isotype Control Purified (Product # 14-4714-82) (left) or Anti-Human Lactoferrin Purified (right) followed by Anti-Mouse IgG Biotin (Product # 13-4013-85) and DAB visualization. Nuclei are counterstained with hematoxylin.