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- Product number
- 10664-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10664-1-AP, RRID:AB_2284207
- Product name
- PRDX3 antibody
- Antibody type
- Polyclonal
- Description
- PRDX3 antibody (Cat. #10664-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Mitochondria-located circRCP regulates redox homeostasis via stabilizing LRPPRC/SLIRP complex to promote bladder urothelial carcinoma tumorigenesis.
SIRT4-Mediated Deacetylation of PRDX3 Attenuates Liver Ischemia Reperfusion Injury by Suppressing Ferroptosis.
Clinical value and molecular role of PRDXs family in prostate cancer.
Melatonin protects chicken follicular granulosa cells against oxidative damage-induced apoptosis via inhibiting FOXO1 signaling pathway.
Age-related declines in mitochondrial Prdx6 contribute to dysregulated muscle bioenergetics.
Inhalation of Ultrafine Carbon Black-Induced Mitochondrial Dysfunction in Mouse Heart Through Changes in Acetylation.
Empagliflozin attenuates renal damage in diabetic nephropathy by modulating mitochondrial quality control via Prdx3-PINK1 pathway.
Itaconate modulates immune responses via inhibition of peroxiredoxin 5.
Artesunate induces ferroptosis in diffuse large B-cell lymphoma cells by targeting PRDX1 and PRDX2.
The miR-320a/PRDX3 Axis Alleviates the Oxidative Stress and Fibrotic Alterations in Fibroblasts in Thyroid Eye Disease.
Aminoguanidine hemisulfate improves mitochondrial autophagy, oxidative stress, and muscle force in Duchenne muscular dystrophy via the AKT/FOXO1 pathway in mdx mice.
Inhibited peroxidase activity of peroxiredoxin 1 by palmitic acid exacerbates nonalcoholic steatohepatitis in male mice.
Copper Drives Remodeling of Metabolic State and Progression of Clear Cell Renal Cell Carcinoma.
Modulation of the thiol redox proteome by sugarcane ash-derived silica nanoparticles: insights into chronic kidney disease of unknown etiology.
ONC206 targeting ClpP induces mitochondrial dysfunction and protective autophagy in hepatocellular carcinoma cells.
YAP1 inhibits the senescence of alveolar epithelial cells by targeting Prdx3 to alleviate pulmonary fibrosis.
Acetyl-11-keto-β-boswellia acid attenuates Ti particle-induced osteoblastic oxidative stress and osteolysis through the Foxo3 signaling pathway.
MUC1-C integrates aerobic glycolysis with suppression of oxidative phosphorylation in triple-negative breast cancer stem cells.
MitoQ ameliorates PM(2.5)-induced pulmonary fibrosis through regulating the mitochondria DNA homeostasis.
Peroxiredoxin-3 plays a neuroprotective role in early brain injury after experimental subarachnoid hemorrhage in rats.
Peroxiredoxins and Hypoxia-Inducible Factor-1α in Duodenal Tissue: Emerging Factors in the Pathophysiology of Pediatric Celiac Disease Patients.
Peroxiredoxins Play an Important Role in the Regulation of Immunity and Aging in Drosophila.
Paeoniflorin Upregulates Mitochondrial Thioredoxin of Schwann Cells to Improve Diabetic Peripheral Neuropathy Indicated by 4D Label-Free Quantitative Proteomics.
Hydrogen Peroxide Promotes the Production of Radiation-Derived EVs Containing Mitochondrial Proteins.
Icariin alleviates uveitis by targeting peroxiredoxin 3 to modulate retinal microglia M1/M2 phenotypic polarization.
Oxidative stress as a candidate mechanism for accelerated neuroectodermal differentiation due to trisomy 21.
Selenium Status in Diet Affects Nephrotoxicity Induced by Cisplatin in Mice.
In Situ Peroxidase Labeling Followed by Mass-Spectrometry Reveals TIA1 Interactome.
Phosphorylation of Dynamin-Related Protein 1 (DRP1) Regulates Mitochondrial Dynamics and Skeletal Muscle Wasting in Cancer Cachexia.
Selenium Status in Diet Affects Acetaminophen-Induced Hepatotoxicity via Interruption of Redox Environment.
Maneb alters central carbon metabolism and thiol redox status in a toxicant model of Parkinson's disease.
LRPPRC regulates redox homeostasis via the circANKHD1/FOXM1 axis to enhance bladder urothelial carcinoma tumorigenesis.
Mitochondria-targeted paraquat and metformin mediate ROS production to induce multiple pathways of retrograde signaling: A dose-dependent phenomenon.
Peroxiredoxins are involved in the pathogenesis of multiple sclerosis and neuromyelitis optica spectrum disorder.
Direct Proteomic Mapping of Cysteine Persulfidation.
Casticin prevents DSS induced ulcerative colitis in mice through inhibitions of NF-κB pathway and ROS signaling.
NNT is a key regulator of adrenal redox homeostasis and steroidogenesis in male mice.
Redox homeostasis protects mitochondria through accelerating ROS conversion to enhance hypoxia resistance in cancer cells.
Mechanistic Study of the Phytocompound, 2- β -D-Glucopyranosyloxy-1-hydroxytrideca-5,7,9,11-tetrayne in Human T-Cell Acute Lymphocytic Leukemia Cells by Using Combined Differential Proteomics and Bioinformatics Approaches.
Thioredoxin Reductase 2 (TXNRD2) mutation associated with familial glucocorticoid deficiency (FGD).
Mitochondrial peroxiredoxin 3 regulates sensory cell survival in the cochlea.
Identification of protein targets underlying dietary nitrate-induced protection against doxorubicin cardiotoxicity.
Proteomics characterization of the cytotoxicity mechanism of ganoderic acid D and computer-automated estimation of the possible drug target network.
Zhou ZH, Wen JH, Zhang YZ, Yao K, Li ZY, Li XD, Wang YJ, Jiang LJ, Ye YL, Qin Z, Liu ZW, Zhou FJ, Chen RX, Xie D, Wei WS
Cancer letters 2026 Jan 28;638:218157
Cancer letters 2026 Jan 28;638:218157
SIRT4-Mediated Deacetylation of PRDX3 Attenuates Liver Ischemia Reperfusion Injury by Suppressing Ferroptosis.
Yu Q, Yang D, Ran B, Pan J, Song Y, Cui M, He Q, Mei C, Wang H, Li H, Li G, Meng Y, Wang F, Guo W, Zhu C, Chen S
International journal of biological sciences 2025;21(10):4663-4682
International journal of biological sciences 2025;21(10):4663-4682
Clinical value and molecular role of PRDXs family in prostate cancer.
Yao Y, Zheng Q, Qian C, Gu P, Zhang M, Zhang Z
Frontiers in oncology 2025;15:1713670
Frontiers in oncology 2025;15:1713670
Melatonin protects chicken follicular granulosa cells against oxidative damage-induced apoptosis via inhibiting FOXO1 signaling pathway.
Liu X, Di K, Chen X, Huang C, Hou F, Hou J, Hao E, Bai K, Wang D, Shi L, Chen Y, Chen H
Poultry science 2025 Sep;104(9):105472
Poultry science 2025 Sep;104(9):105472
Age-related declines in mitochondrial Prdx6 contribute to dysregulated muscle bioenergetics.
Arevalo JA, Xing D, Leija RG, Thorwald MA, Moreno-Santillán DD, Allen KN, Selleghin-Veiga G, Avalos HC, Utke E, Conner JL, Brooks GA, Vázquez-Medina JP
Redox biology 2025 Oct;86:103808
Redox biology 2025 Oct;86:103808
Inhalation of Ultrafine Carbon Black-Induced Mitochondrial Dysfunction in Mouse Heart Through Changes in Acetylation.
Islam R, Stewart JE, Mullen WE, Lin D, Hussain S, Thapa D
Cells 2025 Nov 4;14(21)
Cells 2025 Nov 4;14(21)
Empagliflozin attenuates renal damage in diabetic nephropathy by modulating mitochondrial quality control via Prdx3-PINK1 pathway.
Guo C, Zhang T, Du L, Yu K, Zeng S, Li M, Chi Y, Li Y
Biochemical pharmacology 2025 May;235:116821
Biochemical pharmacology 2025 May;235:116821
Itaconate modulates immune responses via inhibition of peroxiredoxin 5.
Paulenda T, Echalar B, Potuckova L, Vachova V, Kleverov DA, Mehringer J, Potekhina E, Jacoby A, Sen D, Nelson C, Stegeman R, Sukhov V, Kemper D, Lichti CF, Day NJ, Zhang T, Husarcikova K, Bambouskova M, Fremont DH, Qian WJ, Djuranovic S, Pavlovic-Djuranovic S, Belousov VV, Krezel AM, Artyomov MN
Nature metabolism 2025 Jun;7(6):1183-1203
Nature metabolism 2025 Jun;7(6):1183-1203
Artesunate induces ferroptosis in diffuse large B-cell lymphoma cells by targeting PRDX1 and PRDX2.
Liu X, Zeng L, Liu J, Huang Y, Yao H, Zhong J, Tan J, Gao X, Xiong D, Liu L
Cell death & disease 2025 Jul 11;16(1):513
Cell death & disease 2025 Jul 11;16(1):513
The miR-320a/PRDX3 Axis Alleviates the Oxidative Stress and Fibrotic Alterations in Fibroblasts in Thyroid Eye Disease.
Liu S, Yi J, Lu S, Cao J, Xie B, Tan Y, Xiong W
Investigative ophthalmology & visual science 2025 Jul 1;66(9):41
Investigative ophthalmology & visual science 2025 Jul 1;66(9):41
Aminoguanidine hemisulfate improves mitochondrial autophagy, oxidative stress, and muscle force in Duchenne muscular dystrophy via the AKT/FOXO1 pathway in mdx mice.
Sun S, Yu T, Huh JY, Cai Y, Yoon S, Javaid HMA
Skeletal muscle 2025 Jan 13;15(1):2
Skeletal muscle 2025 Jan 13;15(1):2
Inhibited peroxidase activity of peroxiredoxin 1 by palmitic acid exacerbates nonalcoholic steatohepatitis in male mice.
Yin W, Xu H, Bai Z, Wu Y, Zhang Y, Liu R, Wang Z, Zhang B, Shen J, Zhang H, Chen X, Ma D, Shi X, Yan L, Zhang C, Jiang H, Chen K, Guo D, Niu W, Yin H, Zhang WJ, Luo C, Xie X
Nature communications 2025 Jan 11;16(1):598
Nature communications 2025 Jan 11;16(1):598
Copper Drives Remodeling of Metabolic State and Progression of Clear Cell Renal Cell Carcinoma.
Bischoff ME, Shamsaei B, Yang J, Secic D, Vemuri B, Reisz JA, D'Alessandro A, Bartolacci C, Adamczak R, Schmidt L, Wang J, Martines A, Venkat J, Tcheuyap VT, Biesiada J, Behrmann CA, Vest KE, Brugarolas J, Scaglioni PP, Plas DR, Patra KC, Gulati S, Landero Figueroa JA, Meller J, Cunningham JT, Czyzyk-Krzeska MF
Cancer discovery 2025 Feb 7;15(2):401-426
Cancer discovery 2025 Feb 7;15(2):401-426
Modulation of the thiol redox proteome by sugarcane ash-derived silica nanoparticles: insights into chronic kidney disease of unknown etiology.
Stem AD, Michel CR, Harris PS, Rogers KL, Gibb M, Roncal-Jimenez CA, Reisdorph R, Johnson RJ, Roede JR, Fritz KS, Brown JM
Particle and fibre toxicology 2025 Feb 6;22(1):3
Particle and fibre toxicology 2025 Feb 6;22(1):3
ONC206 targeting ClpP induces mitochondrial dysfunction and protective autophagy in hepatocellular carcinoma cells.
Cao J, Cao F, Wang C, Jiao Z, You Y, Wang X, Zhao W
Neoplasia (New York, N.Y.) 2024 Sep;55:101015
Neoplasia (New York, N.Y.) 2024 Sep;55:101015
YAP1 inhibits the senescence of alveolar epithelial cells by targeting Prdx3 to alleviate pulmonary fibrosis.
Su W, Guo Y, Wang Q, Ma L, Zhang Q, Zhang Y, Geng Y, Jin T, Guo J, Yang R, Niu Z, Ren L, Wang Y, Ning Z, Li W, He W, Sun J, Li T, Li Z, Shan H, Liang H
Experimental & molecular medicine 2024 Jul;56(7):1643-1654
Experimental & molecular medicine 2024 Jul;56(7):1643-1654
Acetyl-11-keto-β-boswellia acid attenuates Ti particle-induced osteoblastic oxidative stress and osteolysis through the Foxo3 signaling pathway.
Gu Y, Wu Z, Xie H, Qian Z, Li Z, Tang Y, Wang Q, Fang T, Tao H, Chen K, Zhu P, Ding Y, Xu Y, Peng Y, Ye H, Guo X, Tao Y, Gu Y
International immunopharmacology 2024 Dec 25;143(Pt 3):113547
International immunopharmacology 2024 Dec 25;143(Pt 3):113547
MUC1-C integrates aerobic glycolysis with suppression of oxidative phosphorylation in triple-negative breast cancer stem cells.
Yamashita N, Withers H, Morimoto Y, Bhattacharya A, Haratake N, Daimon T, Fushimi A, Nakashoji A, Thorner AR, Isenhart E, Rosario S, Long MD, Kufe D
iScience 2023 Nov 17;26(11):108168
iScience 2023 Nov 17;26(11):108168
MitoQ ameliorates PM(2.5)-induced pulmonary fibrosis through regulating the mitochondria DNA homeostasis.
Li Y, Du Z, Li T, Ren X, Yu Y, Duan J, Sun Z
Chemosphere 2023 Jul;330:138745
Chemosphere 2023 Jul;330:138745
Peroxiredoxin-3 plays a neuroprotective role in early brain injury after experimental subarachnoid hemorrhage in rats.
Li H, Wang Z, Xie X, Luo M, Shen H, Li X, Li H, Wang Z, Li X, Chen G
Brain research bulletin 2023 Feb;193:95-105
Brain research bulletin 2023 Feb;193:95-105
Peroxiredoxins and Hypoxia-Inducible Factor-1α in Duodenal Tissue: Emerging Factors in the Pathophysiology of Pediatric Celiac Disease Patients.
Köse FA, Pabuccuoglu A, Karakoyun M, Aydogdu S
Current issues in molecular biology 2023 Feb 20;45(2):1779-1793
Current issues in molecular biology 2023 Feb 20;45(2):1779-1793
Peroxiredoxins Play an Important Role in the Regulation of Immunity and Aging in Drosophila.
Odnokoz O, Earland N, Badinloo M, Klichko VI, Benes J, Orr WC, Radyuk SN
Antioxidants (Basel, Switzerland) 2023 Aug 15;12(8)
Antioxidants (Basel, Switzerland) 2023 Aug 15;12(8)
Paeoniflorin Upregulates Mitochondrial Thioredoxin of Schwann Cells to Improve Diabetic Peripheral Neuropathy Indicated by 4D Label-Free Quantitative Proteomics.
Yang X, Li X, Zhu Y, Gao Y, Xu L
Oxidative medicine and cellular longevity 2022;2022:4775645
Oxidative medicine and cellular longevity 2022;2022:4775645
Hydrogen Peroxide Promotes the Production of Radiation-Derived EVs Containing Mitochondrial Proteins.
Miller CE, Xu F, Zhao Y, Luo W, Zhong W, Meyer K, Jayswal R, Weiss HL, St Clair WH, St Clair DK, Chaiswing L
Antioxidants (Basel, Switzerland) 2022 Oct 27;11(11)
Antioxidants (Basel, Switzerland) 2022 Oct 27;11(11)
Icariin alleviates uveitis by targeting peroxiredoxin 3 to modulate retinal microglia M1/M2 phenotypic polarization.
Wang G, Li X, Li N, Wang X, He S, Li W, Fan W, Li R, Liu J, Hou S
Redox biology 2022 Jun;52:102297
Redox biology 2022 Jun;52:102297
Oxidative stress as a candidate mechanism for accelerated neuroectodermal differentiation due to trisomy 21.
Prutton KM, Marentette JO, Leifheit BA, Esquer H, LaBarbera DV, Anderson CC, Maclean KN, Roede JR
Free radical biology & medicine 2022 Jun;186:32-42
Free radical biology & medicine 2022 Jun;186:32-42
Selenium Status in Diet Affects Nephrotoxicity Induced by Cisplatin in Mice.
Liu S, Wen X, Huang Q, Zhu M, Lu J
Antioxidants (Basel, Switzerland) 2022 Jun 10;11(6)
Antioxidants (Basel, Switzerland) 2022 Jun 10;11(6)
In Situ Peroxidase Labeling Followed by Mass-Spectrometry Reveals TIA1 Interactome.
Gourdomichali O, Zonke K, Kattan FG, Makridakis M, Kontostathi G, Vlahou A, Doxakis E
Biology 2022 Feb 11;11(2)
Biology 2022 Feb 11;11(2)
Phosphorylation of Dynamin-Related Protein 1 (DRP1) Regulates Mitochondrial Dynamics and Skeletal Muscle Wasting in Cancer Cachexia.
Mao X, Gu Y, Sui X, Shen L, Han J, Wang H, Xi Q, Zhuang Q, Meng Q, Wu G
Frontiers in cell and developmental biology 2021;9:673618
Frontiers in cell and developmental biology 2021;9:673618
Selenium Status in Diet Affects Acetaminophen-Induced Hepatotoxicity via Interruption of Redox Environment.
Li J, Cheng P, Li S, Zhao P, Han B, Ren X, Zhong JL, Lloyd MD, Pourzand C, Holmgren A, Lu J
Antioxidants & redox signaling 2021 Jun 10;34(17):1355-1367
Antioxidants & redox signaling 2021 Jun 10;34(17):1355-1367
Maneb alters central carbon metabolism and thiol redox status in a toxicant model of Parkinson's disease.
Anderson CC, Marentette JO, Rauniyar AK, Prutton KM, Khatri M, Matheson C, Reisz JA, Reigan P, D'Alessandro A, Roede JR
Free radical biology & medicine 2021 Jan;162:65-76
Free radical biology & medicine 2021 Jan;162:65-76
LRPPRC regulates redox homeostasis via the circANKHD1/FOXM1 axis to enhance bladder urothelial carcinoma tumorigenesis.
Wei WS, Wang N, Deng MH, Dong P, Liu JY, Xiang Z, Li XD, Li ZY, Liu ZH, Peng YL, Li Z, Jiang LJ, Yao K, Ye YL, Lu WH, Zhang ZL, Zhou FJ, Liu ZW, Xie D, Yu CP
Redox biology 2021 Dec;48:102201
Redox biology 2021 Dec;48:102201
Mitochondria-targeted paraquat and metformin mediate ROS production to induce multiple pathways of retrograde signaling: A dose-dependent phenomenon.
Chowdhury AR, Zielonka J, Kalyanaraman B, Hartley RC, Murphy MP, Avadhani NG
Redox biology 2020 Sep;36:101606
Redox biology 2020 Sep;36:101606
Peroxiredoxins are involved in the pathogenesis of multiple sclerosis and neuromyelitis optica spectrum disorder.
Uzawa A, Mori M, Masuda H, Ohtani R, Uchida T, Aoki R, Kuwabara S
Clinical and experimental immunology 2020 Nov;202(2):239-248
Clinical and experimental immunology 2020 Nov;202(2):239-248
Direct Proteomic Mapping of Cysteine Persulfidation.
Fu L, Liu K, He J, Tian C, Yu X, Yang J
Antioxidants & redox signaling 2020 Nov 20;33(15):1061-1076
Antioxidants & redox signaling 2020 Nov 20;33(15):1061-1076
Casticin prevents DSS induced ulcerative colitis in mice through inhibitions of NF-κB pathway and ROS signaling.
Ma J, Yin G, Lu Z, Xie P, Zhou H, Liu J, Yu L
Phytotherapy research : PTR 2018 Sep;32(9):1770-1783
Phytotherapy research : PTR 2018 Sep;32(9):1770-1783
NNT is a key regulator of adrenal redox homeostasis and steroidogenesis in male mice.
Meimaridou E, Goldsworthy M, Chortis V, Fragouli E, Foster PA, Arlt W, Cox R, Metherell LA
The Journal of endocrinology 2018 Jan;236(1):13-28
The Journal of endocrinology 2018 Jan;236(1):13-28
Redox homeostasis protects mitochondria through accelerating ROS conversion to enhance hypoxia resistance in cancer cells.
Li P, Zhang D, Shen L, Dong K, Wu M, Ou Z, Shi D
Scientific reports 2016 Mar 9;6:22831
Scientific reports 2016 Mar 9;6:22831
Mechanistic Study of the Phytocompound, 2- β -D-Glucopyranosyloxy-1-hydroxytrideca-5,7,9,11-tetrayne in Human T-Cell Acute Lymphocytic Leukemia Cells by Using Combined Differential Proteomics and Bioinformatics Approaches.
Shiau JY, Yin SY, Chang SL, Hsu YJ, Chen KW, Kuo TF, Feng CS, Yang NS, Shyur LF, Yang WC, Wen TN
Evidence-based complementary and alternative medicine : eCAM 2015;2015:475610
Evidence-based complementary and alternative medicine : eCAM 2015;2015:475610
Thioredoxin Reductase 2 (TXNRD2) mutation associated with familial glucocorticoid deficiency (FGD).
Prasad R, Chan LF, Hughes CR, Kaski JP, Kowalczyk JC, Savage MO, Peters CJ, Nathwani N, Clark AJ, Storr HL, Metherell LA
The Journal of clinical endocrinology and metabolism 2014 Aug;99(8):E1556-63
The Journal of clinical endocrinology and metabolism 2014 Aug;99(8):E1556-63
Mitochondrial peroxiredoxin 3 regulates sensory cell survival in the cochlea.
Chen FQ, Zheng HW, Schacht J, Sha SH
PloS one 2013;8(4):e61999
PloS one 2013;8(4):e61999
Identification of protein targets underlying dietary nitrate-induced protection against doxorubicin cardiotoxicity.
Xi L, Zhu SG, Hobbs DC, Kukreja RC
Journal of cellular and molecular medicine 2011 Nov;15(11):2512-24
Journal of cellular and molecular medicine 2011 Nov;15(11):2512-24
Proteomics characterization of the cytotoxicity mechanism of ganoderic acid D and computer-automated estimation of the possible drug target network.
Yue QX, Cao ZW, Guan SH, Liu XH, Tao L, Wu WY, Li YX, Yang PY, Liu X, Guo DA
Molecular & cellular proteomics : MCP 2008 May;7(5):949-61
Molecular & cellular proteomics : MCP 2008 May;7(5):949-61
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PRX3 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PRX3. This antibody recognizes human,mouse,rat antigen. The PRX3 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
