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- Antigen structure
- References [18]
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- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 17193-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- RSPO3 antibody
- Antibody type
- Polyclonal
- Description
- RSPO3 antibody (Cat. #17193-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Exosomal Rspondin3 serves as a master regulator of immunometabolic repair in sepsis: synergistic activation of macrophage M2 polarization and endothelial BMP10 signaling.
R-spondin 3 is a myokine that mediates type I fiber determination during skeletal muscle regeneration.
From Gene to Scar: Proteome-Wide Causal Insights into Keloid Pathogenesis and Prevention.
Lonicerin targets ADRA1D and RSPO3 to ameliorate diabetes-induced vascular injury through Ca(2+)/Calcineurin/NFAT1-dependent anti-EndMT pathway.
Wnt signaling drives stromal inflammation in inflammatory arthritis.
Hepatic stellate cells control liver zonation, size and functions via R-spondin 3.
Jawbone periosteum-derived cells with high osteogenic potential controlled by R-spondin 3.
Decreased RSPO3 and β-Catenin in Preeclampsia: Correlation with Blood Pressure and Pregnancy Outcomes.
Astragalus polysaccharide improves diabetic ulcers by promoting M2-polarization of macrophages to reduce excessive inflammation via the β-catenin/ NF-κB axis at the late phase of wound-healing.
RSPO3 induced by Helicobacter pylori extracts promotes gastric cancer stem cell properties through the GNG7/β-catenin signaling pathway.
Endothelial cell-derived RSPO3 activates Gαi1/3-Erk signaling and protects neurons from ischemia/reperfusion injury.
Disturbed flow increases endothelial inflammation and permeability via a Frizzled-4-β-catenin-dependent pathway.
Subtypes in pancreatic ductal adenocarcinoma based on niche factor dependency show distinct drug treatment responses.
Role of R-spondin 2 in arterial lymphangiogenesis and atherosclerosis.
Tumor Microenvironment-Derived R-spondins Enhance Antitumor Immunity to Suppress Tumor Growth and Sensitize for Immune Checkpoint Blockade Therapy.
R-spondin3 promotes the tumor growth of choriocarcinoma JEG-3 cells.
R-Spondin chromosome rearrangements drive Wnt-dependent tumour initiation and maintenance in the intestine.
RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.
Fang B, Long D, Li T, Fu H, Dong Y, Tian Y
International immunopharmacology 2026 May 1;176:116372
International immunopharmacology 2026 May 1;176:116372
R-spondin 3 is a myokine that mediates type I fiber determination during skeletal muscle regeneration.
Hu T, Mita Y, Zhu X, Furuichi Y, Nakagawa Y, Manabe Y, Fujii NL
Molecular biology reports 2025 Oct 9;52(1):995
Molecular biology reports 2025 Oct 9;52(1):995
From Gene to Scar: Proteome-Wide Causal Insights into Keloid Pathogenesis and Prevention.
Xu Y, Liu JC, Jiang Z, Zhang J, He R, Wan M, Zhao S
Advances in wound care 2025 Nov 5;
Advances in wound care 2025 Nov 5;
Lonicerin targets ADRA1D and RSPO3 to ameliorate diabetes-induced vascular injury through Ca(2+)/Calcineurin/NFAT1-dependent anti-EndMT pathway.
Wang M, Cai H, Wang M, Gao H, Zhao X, Rong R, Zhang J, Zhang Z, Liu G, Yuan T, Xia F, Zhu L, Yan Z, Kong X, Qin W
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156832
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156832
Wnt signaling drives stromal inflammation in inflammatory arthritis.
Mueller AA, Zou AE, Marsh LJ, Kemble S, Nayar S, Watts GFM, Murphy CL, Taylor E, Major T, Gardner D, Buckley CD, Wei K, Raychaudhuri S, Korsunsky I, Filer A, Croft AP, Brenner MB
bioRxiv : the preprint server for biology 2025 Jan 8;
bioRxiv : the preprint server for biology 2025 Jan 8;
Hepatic stellate cells control liver zonation, size and functions via R-spondin 3.
Sugimoto A, Saito Y, Wang G, Sun Q, Yin C, Lee KH, Geng Y, Rajbhandari P, Hernandez C, Steffani M, Qie J, Savage T, Goyal DM, Ray KC, Neelakantan TV, Yin D, Melms J, Lehrich BM, Yasaka TM, Liu S, Oertel M, Lan T, Guillot A, Peiseler M, Filliol A, Kanzaki H, Fujiwara N, Ravi S, Izar B, Brosch M, Hampe J, Remotti H, Argemi J, Sun Z, Kendall TJ, Hoshida Y, Tacke F, Fallowfield JA, Blockley-Powell SK, Haeusler RA, Steinman JB, Pajvani UB, Monga SP, Bataller R, Masoodi M, Arpaia N, Lee YA, Stockwell BR, Augustin HG, Schwabe RF
Nature 2025 Apr;640(8059):752-761
Nature 2025 Apr;640(8059):752-761
Jawbone periosteum-derived cells with high osteogenic potential controlled by R-spondin 3.
Zhang S, Zhu J, Jin S, Sun W, Ji W, Chen Z
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Oct 15;38(19):e70079
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Oct 15;38(19):e70079
Decreased RSPO3 and β-Catenin in Preeclampsia: Correlation with Blood Pressure and Pregnancy Outcomes.
Liu Y, Li P, Liao J, Rao M, Peng L, Gan H, Shang L, Xiao Z, Liu X
Medical science monitor : international medical journal of experimental and clinical research 2024 Nov 21;30:e945848
Medical science monitor : international medical journal of experimental and clinical research 2024 Nov 21;30:e945848
Astragalus polysaccharide improves diabetic ulcers by promoting M2-polarization of macrophages to reduce excessive inflammation via the β-catenin/ NF-κB axis at the late phase of wound-healing.
Zhen Z, Wei S, Yunfei W, Jie X, Jienan X, Yiting S, Wen X, Shuyu G, Yue L, Xuanyu W, Yumei Z, Huafa Q
Heliyon 2024 Feb 29;10(4):e24644
Heliyon 2024 Feb 29;10(4):e24644
RSPO3 induced by Helicobacter pylori extracts promotes gastric cancer stem cell properties through the GNG7/β-catenin signaling pathway.
Rao X, Zhang Z, Pu Y, Han G, Gong H, Hu H, Ji Q, Liu N
Cancer medicine 2024 Apr;13(7):e7092
Cancer medicine 2024 Apr;13(7):e7092
Endothelial cell-derived RSPO3 activates Gαi1/3-Erk signaling and protects neurons from ischemia/reperfusion injury.
Liu TT, Shi X, Hu HW, Chen JP, Jiang Q, Zhen YF, Cao C, Liu XW, Liu JG
Cell death & disease 2023 Oct 7;14(10):654
Cell death & disease 2023 Oct 7;14(10):654
Disturbed flow increases endothelial inflammation and permeability via a Frizzled-4-β-catenin-dependent pathway.
Rickman M, Ghim M, Pang K, von Huelsen Rocha AC, Drudi EM, Sureda-Vives M, Ayoub N, Tajadura-Ortega V, George SJ, Weinberg PD, Warboys CM
Journal of cell science 2023 Mar 15;136(6)
Journal of cell science 2023 Mar 15;136(6)
Subtypes in pancreatic ductal adenocarcinoma based on niche factor dependency show distinct drug treatment responses.
Shinkawa T, Ohuchida K, Mochida Y, Sakihama K, Iwamoto C, Abe T, Ideno N, Mizuuchi Y, Shindo K, Ikenaga N, Moriyama T, Nakata K, Oda Y, Nakamura M
Journal of experimental & clinical cancer research : CR 2022 Mar 10;41(1):89
Journal of experimental & clinical cancer research : CR 2022 Mar 10;41(1):89
Role of R-spondin 2 in arterial lymphangiogenesis and atherosclerosis.
Singla B, Lin HP, Chen A, Ahn W, Ghoshal P, Cherian-Shaw M, White J, Stansfield BK, Csányi G
Cardiovascular research 2021 May 25;117(6):1489-1509
Cardiovascular research 2021 May 25;117(6):1489-1509
Tumor Microenvironment-Derived R-spondins Enhance Antitumor Immunity to Suppress Tumor Growth and Sensitize for Immune Checkpoint Blockade Therapy.
Tang Y, Xu Q, Hu L, Yan X, Feng X, Yokota A, Wang W, Zhan D, Krishnamurthy D, Ochayon DE, Wen L, Huo L, Zeng H, Luo Y, Huang LF, Wunderlich M, Zhang J, Vivier E, Zhou J, Waggoner SN, Huang G
Cancer discovery 2021 Dec 1;11(12):3142-3157
Cancer discovery 2021 Dec 1;11(12):3142-3157
R-spondin3 promotes the tumor growth of choriocarcinoma JEG-3 cells.
Chen Z, Zhang J, Yuan A, Han J, Tan L, Zhou Z, Zhao H, Su R, Huang B, Wang B, Sun B, Fan X, Yang Q
American journal of physiology. Cell physiology 2020 Mar 1;318(3):C664-C674
American journal of physiology. Cell physiology 2020 Mar 1;318(3):C664-C674
R-Spondin chromosome rearrangements drive Wnt-dependent tumour initiation and maintenance in the intestine.
Han T, Schatoff EM, Murphy C, Zafra MP, Wilkinson JE, Elemento O, Dow LE
Nature communications 2017 Jul 11;8:15945
Nature communications 2017 Jul 11;8:15945
RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.
Carmon KS, Gong X, Yi J, Thomas A, Liu Q
Proceedings of the National Academy of Sciences of the United States of America 2014 Apr 1;111(13):E1221-9
Proceedings of the National Academy of Sciences of the United States of America 2014 Apr 1;111(13):E1221-9
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse brain tissue were subjected to SDS PAGE followed by western blot with 17193-1-AP( RSPO3 Antibody) at dilution of 1:300
- Other comments
- WB
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemistry of paraffin-embedded human lung cancer tissue slide using 17193-1-AP( RSPO3 Antibody) at dilution of 1:50 (under 40x lens)
- Other comments
- IHC
