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- Antibody Data
- Antigen structure
- References [9]
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- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 17193-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- RSPO3 antibody
- Antibody type
- Polyclonal
- Description
- RSPO3 antibody (Cat. #17193-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Astragalus polysaccharide improves diabetic ulcers by promoting M2-polarization of macrophages to reduce excessive inflammation via the β-catenin/ NF-κB axis at the late phase of wound-healing.
RSPO3 induced by Helicobacter pylori extracts promotes gastric cancer stem cell properties through the GNG7/β-catenin signaling pathway.
Endothelial cell-derived RSPO3 activates Gαi1/3-Erk signaling and protects neurons from ischemia/reperfusion injury.
Disturbed flow increases endothelial inflammation and permeability via a Frizzled-4-β-catenin-dependent pathway.
Subtypes in pancreatic ductal adenocarcinoma based on niche factor dependency show distinct drug treatment responses.
Role of R-spondin 2 in arterial lymphangiogenesis and atherosclerosis.
R-spondin3 promotes the tumor growth of choriocarcinoma JEG-3 cells.
R-Spondin chromosome rearrangements drive Wnt-dependent tumour initiation and maintenance in the intestine.
RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.
Zhen Z, Wei S, Yunfei W, Jie X, Jienan X, Yiting S, Wen X, Shuyu G, Yue L, Xuanyu W, Yumei Z, Huafa Q
Heliyon 2024 Feb 29;10(4):e24644
Heliyon 2024 Feb 29;10(4):e24644
RSPO3 induced by Helicobacter pylori extracts promotes gastric cancer stem cell properties through the GNG7/β-catenin signaling pathway.
Rao X, Zhang Z, Pu Y, Han G, Gong H, Hu H, Ji Q, Liu N
Cancer medicine 2024 Apr;13(7):e7092
Cancer medicine 2024 Apr;13(7):e7092
Endothelial cell-derived RSPO3 activates Gαi1/3-Erk signaling and protects neurons from ischemia/reperfusion injury.
Liu TT, Shi X, Hu HW, Chen JP, Jiang Q, Zhen YF, Cao C, Liu XW, Liu JG
Cell death & disease 2023 Oct 7;14(10):654
Cell death & disease 2023 Oct 7;14(10):654
Disturbed flow increases endothelial inflammation and permeability via a Frizzled-4-β-catenin-dependent pathway.
Rickman M, Ghim M, Pang K, von Huelsen Rocha AC, Drudi EM, Sureda-Vives M, Ayoub N, Tajadura-Ortega V, George SJ, Weinberg PD, Warboys CM
Journal of cell science 2023 Mar 15;136(6)
Journal of cell science 2023 Mar 15;136(6)
Subtypes in pancreatic ductal adenocarcinoma based on niche factor dependency show distinct drug treatment responses.
Shinkawa T, Ohuchida K, Mochida Y, Sakihama K, Iwamoto C, Abe T, Ideno N, Mizuuchi Y, Shindo K, Ikenaga N, Moriyama T, Nakata K, Oda Y, Nakamura M
Journal of experimental & clinical cancer research : CR 2022 Mar 10;41(1):89
Journal of experimental & clinical cancer research : CR 2022 Mar 10;41(1):89
Role of R-spondin 2 in arterial lymphangiogenesis and atherosclerosis.
Singla B, Lin HP, Chen A, Ahn W, Ghoshal P, Cherian-Shaw M, White J, Stansfield BK, Csányi G
Cardiovascular research 2021 May 25;117(6):1489-1509
Cardiovascular research 2021 May 25;117(6):1489-1509
R-spondin3 promotes the tumor growth of choriocarcinoma JEG-3 cells.
Chen Z, Zhang J, Yuan A, Han J, Tan L, Zhou Z, Zhao H, Su R, Huang B, Wang B, Sun B, Fan X, Yang Q
American journal of physiology. Cell physiology 2020 Mar 1;318(3):C664-C674
American journal of physiology. Cell physiology 2020 Mar 1;318(3):C664-C674
R-Spondin chromosome rearrangements drive Wnt-dependent tumour initiation and maintenance in the intestine.
Han T, Schatoff EM, Murphy C, Zafra MP, Wilkinson JE, Elemento O, Dow LE
Nature communications 2017 Jul 11;8:15945
Nature communications 2017 Jul 11;8:15945
RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.
Carmon KS, Gong X, Yi J, Thomas A, Liu Q
Proceedings of the National Academy of Sciences of the United States of America 2014 Apr 1;111(13):E1221-9
Proceedings of the National Academy of Sciences of the United States of America 2014 Apr 1;111(13):E1221-9
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse brain tissue were subjected to SDS PAGE followed by western blot with 17193-1-AP( RSPO3 Antibody) at dilution of 1:300
- Other comments
- WB
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemistry of paraffin-embedded human lung cancer tissue slide using 17193-1-AP( RSPO3 Antibody) at dilution of 1:50 (under 40x lens)
- Other comments
- IHC
