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- Antigen structure
- References [27]
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- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 11464-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11464-1-AP, RRID:AB_2085109
- Product name
- COX17 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated COX17 antibody (Cat. #11464-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Cuproptosis in atrazine-induced hepatotoxicity: ATOX1 as a therapeutic target for lycopene-mediated protection.
Lysophosphatidylcholine acyltransferase 1 promotes head and neck squamous cell carcinoma progression by enhancing COX17-dependent oxidative phosphorylation.
Distinct signaling mechanisms and proteome phenotypes are elicited by compartment-specific genetic defects of copper homeostasis.
MSCs-derived HGF alleviates senescence after AKI by modulating mitoSTAT3-controlled copper flux and respiration.
Copper-mediated MAM regulation of the NF-κB signalling pathway enhances Seneca Valley virus replication in PK-15 cells.
In depth profiling of dihydrolipoamide dehydrogenase deficiency in primary patients fibroblasts reveals metabolic reprogramming secondary to mitochondrial dysfunction.
Adaptive protein synthesis in genetic models of copper deficiency and childhood neurodegeneration.
Lycopene Alleviates Atrazine-Induced Mitochondrial Tricarboxylic Acid Cycle Disorder and Associated Cardiac Cell Senescence and Cuproptosis.
A critical role of N(4)-acetylation of cytidine in mRNA by NAT10 in T cell expansion and antiviral immunity.
Adaptive protein synthesis in genetic models of copper deficiency and childhood neurodegeneration.
Respiratory SARS-CoV-2 Infection Causes Skeletal Muscle Atrophy and Long-Lasting Energy Metabolism Suppression.
Lead aggravates Alzheimer's disease pathology via mitochondrial copper accumulation regulated by COX17.
COX17 restricts renal fibrosis development by maintaining mitochondrial copper homeostasis and restoring complex IV activity.
Mitochondrial respiration reduces exposure of the nucleus to oxygen.
Diosgenin Inhibits ROS Generation by Modulating NOX4 and Mitochondrial Respiratory Chain and Suppresses Apoptosis in Diabetic Nephropathy.
Human TRUB1 is a highly conserved pseudouridine synthase responsible for the formation of Ψ55 in mitochondrial tRNAAsn, tRNAGln, tRNAGlu and tRNAPro.
Exercise improves angiogenic function of circulating exosomes in type 2 diabetes: Role of exosomal SOD3.
Grx2 Regulates Skeletal Muscle Mitochondrial Structure and Autophagy.
Discovery of bactericides as an acute mitochondrial membrane damage inducer.
Bisphenol-A inhibits mitochondrial biogenesis via impairment of GFER mediated mitochondrial protein import in the rat brain hippocampus.
An animal model for mitochondrial tyrosyl-tRNA synthetase deficiency reveals links between oxidative phosphorylation and retinal function.
Disrupting Mitochondrial Copper Distribution Inhibits Leukemic Stem Cell Self-Renewal.
Inhibition of proteasome rescues a pathogenic variant of respiratory chain assembly factor COA7.
Novel interaction of antioxidant-1 with TRAF4: role in inflammatory responses in endothelial cells.
Altered redox mitochondrial biology in the neurodegenerative disorder fragile X-tremor/ataxia syndrome: use of antioxidants in precision medicine.
The mitochondrial disulfide relay system protein GFER is mutated in autosomal-recessive myopathy with cataract and combined respiratory-chain deficiency.
Copper accumulation and compartmentalization in mouse fibroblast lacking metallothionein and copper chaperone, Atox1.
Li NW, Yao X, Lu WH, Zhang YQ, Liu YY, Zhang TT, Zhao Y, Li JL
Journal of advanced research 2026 May;83:823-836
Journal of advanced research 2026 May;83:823-836
Lysophosphatidylcholine acyltransferase 1 promotes head and neck squamous cell carcinoma progression by enhancing COX17-dependent oxidative phosphorylation.
Zhao Y, Li Y, Li Y, Wang Z, Liu C, Chen L, Wang M, Wang M, Cheng Z, Hu G, Pan M
Cell death discovery 2026 Mar 6;12(1)
Cell death discovery 2026 Mar 6;12(1)
Distinct signaling mechanisms and proteome phenotypes are elicited by compartment-specific genetic defects of copper homeostasis.
Lane AR, Gonzalez N, Gokhale A, Zlatic SA, Allen BM, Scher NE, Roberts AM, Duong DM, Roberts BR, Vrailas-Mortimer AD, Werner E, Faundez V
bioRxiv : the preprint server for biology 2026 Jan 14;
bioRxiv : the preprint server for biology 2026 Jan 14;
MSCs-derived HGF alleviates senescence after AKI by modulating mitoSTAT3-controlled copper flux and respiration.
Zhuang K, Wang W, Xu C, Wang S, Chen Y, Zhang Y, Liang Y, Zheng X, Chen X, Feng Z, Cai G
Stem cell research & therapy 2025 Sep 29;16(1):526
Stem cell research & therapy 2025 Sep 29;16(1):526
Copper-mediated MAM regulation of the NF-κB signalling pathway enhances Seneca Valley virus replication in PK-15 cells.
Wu X, Zhu S, Li M, Xu Z, Zhu L, Deng J, Deng H
Veterinary research 2025 Sep 19;56(1):175
Veterinary research 2025 Sep 19;56(1):175
In depth profiling of dihydrolipoamide dehydrogenase deficiency in primary patients fibroblasts reveals metabolic reprogramming secondary to mitochondrial dysfunction.
Sprecher U, Dsouza J, Marisat M, Barasch D, Mishra K, Kakhlon O, Manor J, Anikster Y, Weil M
Molecular genetics and metabolism reports 2025 Mar;42:101172
Molecular genetics and metabolism reports 2025 Mar;42:101172
Adaptive protein synthesis in genetic models of copper deficiency and childhood neurodegeneration.
Lane AR, Scher NE, Bhattacharjee S, Zlatic SA, Roberts AM, Gokhale A, Singleton KS, Duong DM, McKenna M, Liu WL, Baiju A, Moctezuma FGR, Tran T, Patel AA, Clayton LB, Petris MJ, Wood LB, Patgiri A, Vrailas-Mortimer AD, Cox DN, Roberts BR, Werner E, Faundez V
Molecular biology of the cell 2025 Mar 1;36(3):ar33
Molecular biology of the cell 2025 Mar 1;36(3):ar33
Lycopene Alleviates Atrazine-Induced Mitochondrial Tricarboxylic Acid Cycle Disorder and Associated Cardiac Cell Senescence and Cuproptosis.
Li NW, Wang QQ, Zhao Y, Zhang TT, Liu YY, Malhi KK, Yao X, Li JL
Journal of agricultural and food chemistry 2025 Dec 31;73(52):33204-33214
Journal of agricultural and food chemistry 2025 Dec 31;73(52):33204-33214
A critical role of N(4)-acetylation of cytidine in mRNA by NAT10 in T cell expansion and antiviral immunity.
Sun L, Li X, Xu F, Chen Y, Li X, Yang Z, Yang Y, Wang K, Ren T, Lin Z, Wang H, Wang X, Lu Y, Song Z, Cheng ZL, Wu D
Nature immunology 2025 Apr;26(4):619-634
Nature immunology 2025 Apr;26(4):619-634
Adaptive protein synthesis in genetic models of copper deficiency and childhood neurodegeneration.
Lane AR, Scher NE, Bhattacharjee S, Zlatic SA, Roberts AM, Gokhale A, Singleton KS, Duong DM, McKenna M, Liu WL, Baiju A, Moctezuma FGR, Tran T, Patel AA, Clayton LB, Petris MJ, Wood LB, Patgiri A, Vrailas-Mortimer AD, Cox DN, Roberts BR, Werner E, Faundez V
bioRxiv : the preprint server for biology 2024 Nov 18;
bioRxiv : the preprint server for biology 2024 Nov 18;
Respiratory SARS-CoV-2 Infection Causes Skeletal Muscle Atrophy and Long-Lasting Energy Metabolism Suppression.
Homma ST, Wang X, Frere JJ, Gower AC, Zhou J, Lim JK, tenOever BR, Zhou L
Biomedicines 2024 Jun 28;12(7)
Biomedicines 2024 Jun 28;12(7)
Lead aggravates Alzheimer's disease pathology via mitochondrial copper accumulation regulated by COX17.
Huang D, Chen L, Ji Q, Xiang Y, Zhou Q, Chen K, Zhang X, Zou F, Zhang X, Zhao Z, Wang T, Zheng G, Meng X
Redox biology 2024 Feb;69:102990
Redox biology 2024 Feb;69:102990
COX17 restricts renal fibrosis development by maintaining mitochondrial copper homeostasis and restoring complex IV activity.
Zhu SY, Zhou WQ, Niu YY, Zheng C, Liu X, Zhang YY, Yu C
Acta pharmacologica Sinica 2023 Oct;44(10):2091-2102
Acta pharmacologica Sinica 2023 Oct;44(10):2091-2102
Mitochondrial respiration reduces exposure of the nucleus to oxygen.
Mori MP, Penjweini R, Ma J, Alspaugh G, Andreoni A, Kim YC, Wang PY, Knutson JR, Hwang PM
The Journal of biological chemistry 2023 Mar;299(3):103018
The Journal of biological chemistry 2023 Mar;299(3):103018
Diosgenin Inhibits ROS Generation by Modulating NOX4 and Mitochondrial Respiratory Chain and Suppresses Apoptosis in Diabetic Nephropathy.
Zhong Y, Wang L, Jin R, Liu J, Luo R, Zhang Y, Zhu L, Peng X
Nutrients 2023 Apr 30;15(9)
Nutrients 2023 Apr 30;15(9)
Human TRUB1 is a highly conserved pseudouridine synthase responsible for the formation of Ψ55 in mitochondrial tRNAAsn, tRNAGln, tRNAGlu and tRNAPro.
Jia Z, Meng F, Chen H, Zhu G, Li X, He Y, Zhang L, He X, Zhan H, Chen M, Ji Y, Wang M, Guan MX
Nucleic acids research 2022 Sep 9;50(16):9368-9381
Nucleic acids research 2022 Sep 9;50(16):9368-9381
Exercise improves angiogenic function of circulating exosomes in type 2 diabetes: Role of exosomal SOD3.
Abdelsaid K, Sudhahar V, Harris RA, Das A, Youn SW, Liu Y, McMenamin M, Hou Y, Fulton D, Hamrick MW, Tang Y, Fukai T, Ushio-Fukai M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Mar;36(3):e22177
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Mar;36(3):e22177
Grx2 Regulates Skeletal Muscle Mitochondrial Structure and Autophagy.
Liaghati A, Pileggi CA, Parmar G, Patten DA, Hadzimustafic N, Cuillerier A, Menzies KJ, Burelle Y, Harper ME
Frontiers in physiology 2021;12:604210
Frontiers in physiology 2021;12:604210
Discovery of bactericides as an acute mitochondrial membrane damage inducer.
Houston R, Sekine Y, Larsen MB, Murakami K, Mullett SJ, Wendell SG, Narendra DP, Chen BB, Sekine S
Molecular biology of the cell 2021 Nov 1;32(21):ar32
Molecular biology of the cell 2021 Nov 1;32(21):ar32
Bisphenol-A inhibits mitochondrial biogenesis via impairment of GFER mediated mitochondrial protein import in the rat brain hippocampus.
Goyal S, Tiwari S, Seth B, Tandon A, Shankar J, Sinha M, Singh SJ, Priya S, Chaturvedi RK
Neurotoxicology 2021 Jul;85:18-32
Neurotoxicology 2021 Jul;85:18-32
An animal model for mitochondrial tyrosyl-tRNA synthetase deficiency reveals links between oxidative phosphorylation and retinal function.
Jin X, Zhang Z, Nie Z, Wang C, Meng F, Yi Q, Chen M, Sun J, Zou J, Jiang P, Guan MX
The Journal of biological chemistry 2021 Jan-Jun;296:100437
The Journal of biological chemistry 2021 Jan-Jun;296:100437
Disrupting Mitochondrial Copper Distribution Inhibits Leukemic Stem Cell Self-Renewal.
Singh RP, Jeyaraju DV, Voisin V, Hurren R, Xu C, Hawley JR, Barghout SH, Khan DH, Gronda M, Wang X, Jitkova Y, Sharon D, Liyanagae S, MacLean N, Seneviratene AK, Mirali S, Borenstein A, Thomas GE, Soriano J, Orouji E, Minden MD, Arruda A, Chan SM, Bader GD, Lupien M, Schimmer AD
Cell stem cell 2020 Jun 4;26(6):926-937.e10
Cell stem cell 2020 Jun 4;26(6):926-937.e10
Inhibition of proteasome rescues a pathogenic variant of respiratory chain assembly factor COA7.
Mohanraj K, Wasilewski M, Benincá C, Cysewski D, Poznanski J, Sakowska P, Bugajska Z, Deckers M, Dennerlein S, Fernandez-Vizarra E, Rehling P, Dadlez M, Zeviani M, Chacinska A
EMBO molecular medicine 2019 May;11(5)
EMBO molecular medicine 2019 May;11(5)
Novel interaction of antioxidant-1 with TRAF4: role in inflammatory responses in endothelial cells.
Das A, Sudhahar V, Ushio-Fukai M, Fukai T
American journal of physiology. Cell physiology 2019 Dec 1;317(6):C1161-C1171
American journal of physiology. Cell physiology 2019 Dec 1;317(6):C1161-C1171
Altered redox mitochondrial biology in the neurodegenerative disorder fragile X-tremor/ataxia syndrome: use of antioxidants in precision medicine.
Song G, Napoli E, Wong S, Hagerman R, Liu S, Tassone F, Giulivi C
Molecular medicine (Cambridge, Mass.) 2016 Oct;22:548-559
Molecular medicine (Cambridge, Mass.) 2016 Oct;22:548-559
The mitochondrial disulfide relay system protein GFER is mutated in autosomal-recessive myopathy with cataract and combined respiratory-chain deficiency.
Di Fonzo A, Ronchi D, Lodi T, Fassone E, Tigano M, Lamperti C, Corti S, Bordoni A, Fortunato F, Nizzardo M, Napoli L, Donadoni C, Salani S, Saladino F, Moggio M, Bresolin N, Ferrero I, Comi GP
American journal of human genetics 2009 May;84(5):594-604
American journal of human genetics 2009 May;84(5):594-604
Copper accumulation and compartmentalization in mouse fibroblast lacking metallothionein and copper chaperone, Atox1.
Miyayama T, Suzuki KT, Ogra Y
Toxicology and applied pharmacology 2009 Jun 1;237(2):205-13
Toxicology and applied pharmacology 2009 Jun 1;237(2):205-13
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human heart tissue were subjected to SDS PAGE followed by western blot with 11464-1-AP(COX17 antibody) at dilution of 1:300
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The COX17 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human COX17. This antibody recognizes human, mouse, rat antigen. The COX17 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
