Antibody data
- Antibody Data
- Antigen structure
- References [16]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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Validation data
Reference
Comment
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- Product number
- 11464-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11464-1-AP, RRID:AB_2085109
- Product name
- COX17 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated COX17 antibody (Cat. #11464-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Lead aggravates Alzheimer's disease pathology via mitochondrial copper accumulation regulated by COX17.
COX17 restricts renal fibrosis development by maintaining mitochondrial copper homeostasis and restoring complex IV activity.
Mitochondrial respiration reduces exposure of the nucleus to oxygen.
Diosgenin Inhibits ROS Generation by Modulating NOX4 and Mitochondrial Respiratory Chain and Suppresses Apoptosis in Diabetic Nephropathy.
Human TRUB1 is a highly conserved pseudouridine synthase responsible for the formation of Ψ55 in mitochondrial tRNAAsn, tRNAGln, tRNAGlu and tRNAPro.
Exercise improves angiogenic function of circulating exosomes in type 2 diabetes: Role of exosomal SOD3.
Grx2 Regulates Skeletal Muscle Mitochondrial Structure and Autophagy.
Discovery of bactericides as an acute mitochondrial membrane damage inducer.
Bisphenol-A inhibits mitochondrial biogenesis via impairment of GFER mediated mitochondrial protein import in the rat brain hippocampus.
An animal model for mitochondrial tyrosyl-tRNA synthetase deficiency reveals links between oxidative phosphorylation and retinal function.
Disrupting Mitochondrial Copper Distribution Inhibits Leukemic Stem Cell Self-Renewal.
Inhibition of proteasome rescues a pathogenic variant of respiratory chain assembly factor COA7.
Novel interaction of antioxidant-1 with TRAF4: role in inflammatory responses in endothelial cells.
Altered redox mitochondrial biology in the neurodegenerative disorder fragile X-tremor/ataxia syndrome: use of antioxidants in precision medicine.
The mitochondrial disulfide relay system protein GFER is mutated in autosomal-recessive myopathy with cataract and combined respiratory-chain deficiency.
Copper accumulation and compartmentalization in mouse fibroblast lacking metallothionein and copper chaperone, Atox1.
Huang D, Chen L, Ji Q, Xiang Y, Zhou Q, Chen K, Zhang X, Zou F, Zhang X, Zhao Z, Wang T, Zheng G, Meng X
Redox biology 2024 Feb;69:102990
Redox biology 2024 Feb;69:102990
COX17 restricts renal fibrosis development by maintaining mitochondrial copper homeostasis and restoring complex IV activity.
Zhu SY, Zhou WQ, Niu YY, Zheng C, Liu X, Zhang YY, Yu C
Acta pharmacologica Sinica 2023 Oct;44(10):2091-2102
Acta pharmacologica Sinica 2023 Oct;44(10):2091-2102
Mitochondrial respiration reduces exposure of the nucleus to oxygen.
Mori MP, Penjweini R, Ma J, Alspaugh G, Andreoni A, Kim YC, Wang PY, Knutson JR, Hwang PM
The Journal of biological chemistry 2023 Mar;299(3):103018
The Journal of biological chemistry 2023 Mar;299(3):103018
Diosgenin Inhibits ROS Generation by Modulating NOX4 and Mitochondrial Respiratory Chain and Suppresses Apoptosis in Diabetic Nephropathy.
Zhong Y, Wang L, Jin R, Liu J, Luo R, Zhang Y, Zhu L, Peng X
Nutrients 2023 Apr 30;15(9)
Nutrients 2023 Apr 30;15(9)
Human TRUB1 is a highly conserved pseudouridine synthase responsible for the formation of Ψ55 in mitochondrial tRNAAsn, tRNAGln, tRNAGlu and tRNAPro.
Jia Z, Meng F, Chen H, Zhu G, Li X, He Y, Zhang L, He X, Zhan H, Chen M, Ji Y, Wang M, Guan MX
Nucleic acids research 2022 Sep 9;50(16):9368-9381
Nucleic acids research 2022 Sep 9;50(16):9368-9381
Exercise improves angiogenic function of circulating exosomes in type 2 diabetes: Role of exosomal SOD3.
Abdelsaid K, Sudhahar V, Harris RA, Das A, Youn SW, Liu Y, McMenamin M, Hou Y, Fulton D, Hamrick MW, Tang Y, Fukai T, Ushio-Fukai M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Mar;36(3):e22177
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Mar;36(3):e22177
Grx2 Regulates Skeletal Muscle Mitochondrial Structure and Autophagy.
Liaghati A, Pileggi CA, Parmar G, Patten DA, Hadzimustafic N, Cuillerier A, Menzies KJ, Burelle Y, Harper ME
Frontiers in physiology 2021;12:604210
Frontiers in physiology 2021;12:604210
Discovery of bactericides as an acute mitochondrial membrane damage inducer.
Houston R, Sekine Y, Larsen MB, Murakami K, Mullett SJ, Wendell SG, Narendra DP, Chen BB, Sekine S
Molecular biology of the cell 2021 Nov 1;32(21):ar32
Molecular biology of the cell 2021 Nov 1;32(21):ar32
Bisphenol-A inhibits mitochondrial biogenesis via impairment of GFER mediated mitochondrial protein import in the rat brain hippocampus.
Goyal S, Tiwari S, Seth B, Tandon A, Shankar J, Sinha M, Singh SJ, Priya S, Chaturvedi RK
Neurotoxicology 2021 Jul;85:18-32
Neurotoxicology 2021 Jul;85:18-32
An animal model for mitochondrial tyrosyl-tRNA synthetase deficiency reveals links between oxidative phosphorylation and retinal function.
Jin X, Zhang Z, Nie Z, Wang C, Meng F, Yi Q, Chen M, Sun J, Zou J, Jiang P, Guan MX
The Journal of biological chemistry 2021 Jan-Jun;296:100437
The Journal of biological chemistry 2021 Jan-Jun;296:100437
Disrupting Mitochondrial Copper Distribution Inhibits Leukemic Stem Cell Self-Renewal.
Singh RP, Jeyaraju DV, Voisin V, Hurren R, Xu C, Hawley JR, Barghout SH, Khan DH, Gronda M, Wang X, Jitkova Y, Sharon D, Liyanagae S, MacLean N, Seneviratene AK, Mirali S, Borenstein A, Thomas GE, Soriano J, Orouji E, Minden MD, Arruda A, Chan SM, Bader GD, Lupien M, Schimmer AD
Cell stem cell 2020 Jun 4;26(6):926-937.e10
Cell stem cell 2020 Jun 4;26(6):926-937.e10
Inhibition of proteasome rescues a pathogenic variant of respiratory chain assembly factor COA7.
Mohanraj K, Wasilewski M, Benincá C, Cysewski D, Poznanski J, Sakowska P, Bugajska Z, Deckers M, Dennerlein S, Fernandez-Vizarra E, Rehling P, Dadlez M, Zeviani M, Chacinska A
EMBO molecular medicine 2019 May;11(5)
EMBO molecular medicine 2019 May;11(5)
Novel interaction of antioxidant-1 with TRAF4: role in inflammatory responses in endothelial cells.
Das A, Sudhahar V, Ushio-Fukai M, Fukai T
American journal of physiology. Cell physiology 2019 Dec 1;317(6):C1161-C1171
American journal of physiology. Cell physiology 2019 Dec 1;317(6):C1161-C1171
Altered redox mitochondrial biology in the neurodegenerative disorder fragile X-tremor/ataxia syndrome: use of antioxidants in precision medicine.
Song G, Napoli E, Wong S, Hagerman R, Liu S, Tassone F, Giulivi C
Molecular medicine (Cambridge, Mass.) 2016 Oct;22:548-559
Molecular medicine (Cambridge, Mass.) 2016 Oct;22:548-559
The mitochondrial disulfide relay system protein GFER is mutated in autosomal-recessive myopathy with cataract and combined respiratory-chain deficiency.
Di Fonzo A, Ronchi D, Lodi T, Fassone E, Tigano M, Lamperti C, Corti S, Bordoni A, Fortunato F, Nizzardo M, Napoli L, Donadoni C, Salani S, Saladino F, Moggio M, Bresolin N, Ferrero I, Comi GP
American journal of human genetics 2009 May;84(5):594-604
American journal of human genetics 2009 May;84(5):594-604
Copper accumulation and compartmentalization in mouse fibroblast lacking metallothionein and copper chaperone, Atox1.
Miyayama T, Suzuki KT, Ogra Y
Toxicology and applied pharmacology 2009 Jun 1;237(2):205-13
Toxicology and applied pharmacology 2009 Jun 1;237(2):205-13
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human heart tissue were subjected to SDS PAGE followed by western blot with 11464-1-AP(COX17 antibody) at dilution of 1:300
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The COX17 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human COX17. This antibody recognizes human, mouse, rat antigen. The COX17 antibody has been validated for the following applications: ELISA, WB, IHC analysis.