17724-1-AP

antibody from Proteintech Group

Targeting: PRDX5 ACR1, AOEB166, B166, MGC117264, MGC142283, MGC142285, PLP, PMP20, PRDX6, PRXV, SBBI10

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunocytochemistry (Supportive data in Antibodypedia)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

17724-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#17724-1-AP, RRID:AB_2168628

Product name

PRX5 antibody

Antibody type

Polyclonal

Description

PRX5 antibody (Cat. #17724-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Identification of the Antioxidant Enzyme B166 as a Novel Biomarker for Patients With Glioblastoma Multiforme.

Liu W, Wang B, Kong F, Cheung C
Analytical cellular pathology (Amsterdam) 2026;2026(1):e6120748

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Clinical value and molecular role of PRDXs family in prostate cancer.

Yao Y, Zheng Q, Qian C, Gu P, Zhang M, Zhang Z
Frontiers in oncology 2025;15:1713670

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Activation of SIRT3 / PRDX5 signaling inhibits apoptosis after acute spinal cord injury in mice.

Ni H, Sha W, Xu T, Zhu Q, Huang Q, Wang J, Gu Q, Zhu Y, Wang L, Tian S, Gao R, Ge J, Lin X
Brain research bulletin 2025 Oct 1;230:111510

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Inhalation of Ultrafine Carbon Black-Induced Mitochondrial Dysfunction in Mouse Heart Through Changes in Acetylation.

Islam R, Stewart JE, Mullen WE, Lin D, Hussain S, Thapa D
Cells 2025 Nov 4;14(21)

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Characterization of the Biochemical Recurrence Prediction Ability and Progression Correlation of Peroxiredoxins Family in Prostate Cancer Based on Integrating Single-Cell RNA-Seq and Bulk RNA-Seq Cohorts.

Tang S, Li J, Tian W, Feng Y, Deng Y, Tan Z, Han Z, He H, Wu Y, Huang C, Ning K, Liu F, Luo H, Cai S, Ye J, Zhong W
Cancer medicine 2025 May;14(9):e70855

---

Dynamic PRDX S-acylation modulates ROS stress and signaling.

Qiu T, Azizi SA, Pani S, Dickinson BC
Cell chemical biology 2025 Mar 20;32(3):511-519.e5

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Itaconate modulates immune responses via inhibition of peroxiredoxin 5.

Paulenda T, Echalar B, Potuckova L, Vachova V, Kleverov DA, Mehringer J, Potekhina E, Jacoby A, Sen D, Nelson C, Stegeman R, Sukhov V, Kemper D, Lichti CF, Day NJ, Zhang T, Husarcikova K, Bambouskova M, Fremont DH, Qian WJ, Djuranovic S, Pavlovic-Djuranovic S, Belousov VV, Krezel AM, Artyomov MN
Nature metabolism 2025 Jun;7(6):1183-1203

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Inhibited peroxidase activity of peroxiredoxin 1 by palmitic acid exacerbates nonalcoholic steatohepatitis in male mice.

Yin W, Xu H, Bai Z, Wu Y, Zhang Y, Liu R, Wang Z, Zhang B, Shen J, Zhang H, Chen X, Ma D, Shi X, Yan L, Zhang C, Jiang H, Chen K, Guo D, Niu W, Yin H, Zhang WJ, Luo C, Xie X
Nature communications 2025 Jan 11;16(1):598

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Peroxisomal lipid metabolism inhibits Pimozide-induced cancer cell death by regulating ATP homeostasis.

Pan Z, Yu F, You W, Li F, Cui F, Guo J, Yang Z
Oncogenesis 2025 Aug 21;14(1):31

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Chaihuang Yishen Granule ameliorates mitochondrial homeostasis by upregulating PRDX5/TFAM axis to inhibit renal fibrosis in CKD.

Xu LH, Tan RZ, Lin JY, Li T, Jia J, Wu LH, Wang R, He YH, Su HW, Li P, Wang L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156426

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Elevated serum levels of GPX4, NDUFS4, PRDX5, and TXNRD2 as predictive biomarkers for castration resistance in prostate cancer patients: an exploratory study.

Wang R, Wang S, Mi Y, Huang T, Wang J, Ni J, Wang J, Yin J, Li M, Ran X, Fan S, Sun Q, Tan SY, Phillip Koeffler H, Ding L, Chen YQ, Feng N
British journal of cancer 2025 Apr;132(6):543-557

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Prdx5 regulates macrophage polarization by modulating the TLR4/NF-κB pathway to promote apoptosis in chronic prostatitis.

Wu W, Meng T, Wang Y, Chen J, Liang C
International immunopharmacology 2025 Apr 4;151:114332

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MitoQ ameliorates PM(2.5)-induced pulmonary fibrosis through regulating the mitochondria DNA homeostasis.

Li Y, Du Z, Li T, Ren X, Yu Y, Duan J, Sun Z
Chemosphere 2023 Jul;330:138745

---

Prdx5 regulates DNA damage response through autophagy-dependent Sirt2-p53 axis.

Agborbesong E, Zhou JX, Li LX, Harris PC, Calvet JP, Li X
Human molecular genetics 2023 Jan 27;32(4):567-579

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Peroxiredoxins and Hypoxia-Inducible Factor-1α in Duodenal Tissue: Emerging Factors in the Pathophysiology of Pediatric Celiac Disease Patients.

Köse FA, Pabuccuoglu A, Karakoyun M, Aydogdu S
Current issues in molecular biology 2023 Feb 20;45(2):1779-1793

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Peroxiredoxins Play an Important Role in the Regulation of Immunity and Aging in Drosophila.

Odnokoz O, Earland N, Badinloo M, Klichko VI, Benes J, Orr WC, Radyuk SN
Antioxidants (Basel, Switzerland) 2023 Aug 15;12(8)

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Antioxidant enzyme peroxiredoxin 5 regulates cyst growth and ciliogenesis via modulating Plk1 stability.

Agborbesong E, Zhou JX, Li LX, Calvet JP, Li X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Jan;36(1):e22089

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Effect of Shenkang on renal fibrosis and activation of renal interstitial fibroblasts through the JAK2/STAT3 pathway.

Qin T, Wu Y, Liu T, Wu L
BMC complementary medicine and therapies 2021 Jan 6;21(1):12

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Peroxiredoxins are involved in the pathogenesis of multiple sclerosis and neuromyelitis optica spectrum disorder.

Uzawa A, Mori M, Masuda H, Ohtani R, Uchida T, Aoki R, Kuwabara S
Clinical and experimental immunology 2020 Nov;202(2):239-248

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Novel [1,2,3]triazolo[4,5-d]pyrimidine derivatives containing hydrazone fragment as potent and selective anticancer agents.

Xu C, Zhou W, Dong G, Qiao H, Peng J, Jia P, Li Y, Liu H, Sun K, Zhao W
Bioorganic chemistry 2020 Dec;105:104424

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LncRNA GABPB1-AS1 and GABPB1 regulate oxidative stress during erastin-induced ferroptosis in HepG2 hepatocellular carcinoma cells.

Qi W, Li Z, Xia L, Dai J, Zhang Q, Wu C, Xu S
Scientific reports 2019 Nov 7;9(1):16185

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miR‑153 promotes neural differentiation in the mouse hippocampal HT‑22 cell line and increases the expression of neuron‑specific enolase.

Xu C, Wang C, Meng Q, Gu Y, Wang Q, Xu W, Han Y, Qin Y, Li J, Jia S, Xu J, Zhou Y
Molecular medicine reports 2019 Aug;20(2):1725-1735

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Luteolin ameliorates rat myocardial ischaemia-reperfusion injury through activation of peroxiredoxin II.

Wei B, Lin Q, Ji YG, Zhao YC, Ding LN, Zhou WJ, Zhang LH, Gao CY, Zhao W
British journal of pharmacology 2018 Aug;175(16):3315-3332

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Aberrant expression of redox regulatory proteins in patients with concomitant primary Sclerosing cholangitis/inflammatory bowel disease.

Petersen DR, Orlicky DJ, Roede JR, Shearn CT
Experimental and molecular pathology 2018 Aug;105(1):32-36

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Ruthenium(II) Complexes with 2-Phenylimidazo[4,5-f][1,10]phenanthroline Derivatives that Strongly Combat Cisplatin-Resistant Tumor Cells.

Zeng L, Chen Y, Liu J, Huang H, Guan R, Ji L, Chao H
Scientific reports 2016 Jan 14;6:19449

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Beetroot juice reduces infarct size and improves cardiac function following ischemia-reperfusion injury: Possible involvement of endogenous H2S.

Salloum FN, Sturz GR, Yin C, Rehman S, Hoke NN, Kukreja RC, Xi L
Experimental biology and medicine (Maywood, N.J.) 2015 May;240(5):669-81

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Mammalian target of rapamycin (mTOR) inhibition with rapamycin improves cardiac function in type 2 diabetic mice: potential role of attenuated oxidative stress and altered contractile protein expression.

Das A, Durrant D, Koka S, Salloum FN, Xi L, Kukreja RC
The Journal of biological chemistry 2014 Feb 14;289(7):4145-60

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Identification of protein targets underlying dietary nitrate-induced protection against doxorubicin cardiotoxicity.

Xi L, Zhu SG, Hobbs DC, Kukreja RC
Journal of cellular and molecular medicine 2011 Nov;15(11):2512-24

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

mouse kidney tissue were subjected to SDS PAGE followed by western blot with 17724-1-AP(Prx5 antibody) at dilution of 1:600

Sample type

tissue

Immunocytochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunofluorescent analysis of HepG2 cells, using PRDX5 antibody 17724-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).

Sample type

cell line

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human kidney using 17724-1-AP(Prx5 antibody) at dilution of 1:50 (under 10x lens)

Sample type

tissue

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human kidney using 17724-1-AP(Prx5 antibody) at dilution of 1:50 (under 40x lens)

Sample type

tissue