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- Product number
- 21800-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#21800-1-AP, RRID:AB_10858790
- Product name
- EZH2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated EZH2 antibody (Cat. #21800-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Dual function of DOT1L suppresses tumor cell-intrinsic immunogenicity in hepatocellular carcinoma.
HHV-6A Drives Epigenetic Reprogramming via an EZH2-SIRT1 Axis to Sustain Mutant p53 and Reshape Oncogenic Inflammatory Signaling.
RG108-Conjugated Platinum(IV) Prodrugs: Enhanced Efficacy and Reduced Ototoxicity.
Interplay between nuclear survivin and the PRC2 complex and its impact on H3K27me3-directed transcriptional repression.
The PTBP1-EZH2-DOCK2 axis promotes M1 microglial polarization and exacerbates neuronal apoptosis following spinal cord injury.
Mechanically heterogeneous hydrogel with cell-programmed network restructuring promotes tissue regeneration by mechano-epigenetic modulation.
Neutrophil-derived exosomes inhibit gastric cancer progression via miR-101-3p-mediated suppression of MCL1.
Therapeutic effects of the n-butanol extract of Potentilla freyniana Bornm. in hepatocellular carcinoma cells.
SA supplementation during lactation promotes learning and memory by reducing H3K27me3 levels.
Characterization of gRNA-dependent and gRNA-independent off-target binding sites of PspCas13b and RfxCas13d in mammalian cells.
PDGF-BB mitigates pericyte injury by activating the PHF19-PRC2 complex via the miR-221/BRCA1 signaling axis in Alzheimer's disease.
Analysis of histone modifications in key cellular subpopulations in the context of azoospermia using spermatogenic single-cell RNA-seq data.
DEK promotes mammary hyperplasia and is associated with H3K27me3 epigenetic modifications.
Interplay mechanism of virus latency-reactivation by human cytomegalovirus UL82 protein with the host core histone H3K27 methyltransferase EZH2 of polycomb repressive complex 2.
KDM4B modulates ERα signaling pathway to participate in vascular smooth muscle cell calcification.
EZH2 confers lenvatinib resistance in hepatocellular carcinoma by suppressing ACSL1-Mediated ferroptosis.
EZH2-mediated downregulation of miR-155-5p contributes to prostate cancer cell malignancy through SMAD2 and TAB2.
Substrate stiffness modulates osteogenic and adipogenic differentiation of osteosarcoma through PIEZO1 mediated signaling pathway.
NEAT1 promotes the perineural invasion of pancreatic cancer via the E2F1/GDNF axis.
Bilateral Synergistic Effects of Phototherapy-Based NIR-II Absorption Photosensitizer for Allergic Rhinitis.
Significant prognostic value of cell-cycle proteins in early-stage small cell carcinoma of cervix.
Modulatory Effect of Curcumin on Expression of Methyltransferase/Demethylase in Colon Cancer Cells: Impact on wt p53, mutp53 and c-Myc.
SIX1 aggravates the progression of spinal cord injury in mice by promoting M1 polarization of microglia.
Changes in Lysine Methylation Contribute to the Cytotoxicity of Curcumin in Colon Cancer Cells.
NCAPD3-mediated AKT activation regulates prostate cancer progression.
Maternal obesity alters histone modifications mediated by the interaction between EZH2 and AMPK, impairing neural differentiation in the developing embryonic brain cortex.
Armadillo domain of ARID1A directly interacts with DNA-PKcs to couple chromatin remodeling with nonhomologous end joining (NHEJ) pathway.
Mettl3/Eed/Ythdc1 regulatory axis controls endometrial receptivity and function.
USP44 promotes chemotherapeutic drug resistance of triple negative breast cancer through EZH2 protein stability.
Association of TP53 and EZH2 with salivary adenoid cystic carcinoma.
Therapeutic targeting SPI1 in combination with erastin promotes ferroptosis in ccRCC.
Paternal Obesity-Induced H3K27me3 Elevation Leads to MANF-Mediated Transgenerational Metabolic Dysfunction in Female Offspring.
SUMO E3 ligase MUL1 inhibits lymph node metastasis of bladder cancer by mediating mitochondrial HSPA9 translocation.
Potential mechanism of Luoshi Neiyi prescription in endometriosis based on serum pharmacochemistry and network pharmacology.
LncRNA FEZF1-AS1 promotes pulmonary fibrosis via up-regulating EZH2 and targeting miR-200c-3p to regulate the ZEB1 pathway.
VprBP regulates osteoclast differentiation via an epigenetic mechanism involving histone H2A phosphorylation.
The in vivo effects of knockdown of long non-coding RNA XIST on fibroid growth and gene expression.
The E3 ubiquitin ligase RNF220 maintains hindbrain Hox expression patterns through regulation of WDR5 stability.
Manganese induces podocyte injury through regulating MTDH/ALKBH5/NLRP10 axis: Combined analysis at epidemiology and molecular biology levels.
Long non-coding RNA HOTAIR: from pan-cancer analysis to colorectal cancer-related uridine metabolism.
Inhibition of protein kinase C increases Prdm14 level to promote self-renewal of embryonic stem cells through reducing Suv39h-induced H3K9 methylation.
Cell surface CD55 traffics to the nucleus leading to cisplatin resistance and stemness by inducing PRC2 and H3K27 trimethylation on chromatin in ovarian cancer.
EZH2 suppresses ferroptosis in hepatocellular carcinoma and reduces sorafenib sensitivity through epigenetic regulation of TFR2.
The m(6)A reader YTHDC2 regulates UVB-induced DNA damage repair and histone modification.
CircARAP2 controls sMICA-induced NK cell desensitization by erasing CTCF/PRC2-induced suppression in early endosome marker RAB5A.
JMJD3 regulate H3K27me3 modification via interacting directly with TET1 to affect spermatogonia self-renewal and proliferation.
NIPBL-mediated RAD21 facilitates tumorigenicity by the PI3K pathway in non-small-cell lung cancer.
MAPRE3 as an epigenetic target of EZH2 restricts ovarian cancer proliferation in vitro and in vivo.
MAT2A is essential for zygotic genome activation by maintaining of histone methylation in porcine embryos.
Corynoxine exerts the anti-tumor effect on esophageal squamous cell carcinoma principally via the EZH2-DUSP5-ERK1/2-mediated cell growth inhibition.
Luoshi Neiyi Prescription inhibits estradiol synthesis and inflammation in endometriosis through the HIF1A/EZH2/SF-1 pathway.
ORC1 enhances repressive epigenetic modifications on HIV-1 LTR to promote HIV-1 latency.
Iron overload increases the sensitivity of endometriosis stromal cells to ferroptosis via a PRC2-independent function of EZH2.
Epigenetic regulation of FOXI2 promotes clear cell renal cell carcinoma progression.
EZH2-dependent epigenetic reprogramming in the central nucleus of amygdala regulates adult anxiety in both sexes after adolescent alcohol exposure.
LncRNA HOTAIR Enhances Epithelial-to-mesenchymal Transition to Promote the Migration and Invasion of Liver Cancer by Regulating NUAK1 via Epigenetic Inhibition miR-145-5p Expression.
Cyclohexene oxide CA, a derivative of zeylenone, exhibits anti-cancer activity in glioblastoma by inducing G0/G1 phase arrest through interference with EZH2.
Histone H3K27 methyltransferase EZH2 regulates apoptotic and inflammatory responses in sepsis-induced AKI.
Overexpression of RACGAP1 by E2F1 Promotes Neuroendocrine Differentiation of Prostate Cancer by Stabilizing EZH2 Expression.
Pb inhibited C2C12 myoblast differentiation by regulating HDAC2.
Knockdown of Bach1 protects periodontal bone regeneration from inflammatory damage.
EZH2 Gene Knockdown Inhibits Sheep Pituitary Cell Proliferation via Downregulating the AKT/ERK Signaling Pathway.
Nucleolus assembly impairment leads to two-cell transcriptional repression via NPM1-mediated PRC2 recruitment.
A targetable MYBL2-ATAD2 axis governs cell proliferation in ovarian cancer.
Azithromycin attenuates wheezing after pulmonary inflammation through inhibiting histone H3K27me3 hypermethylation mediated by EZH2.
LncRNA H19-EZH2 interaction promotes liver fibrosis via reprogramming H3K27me3 profiles.
SND1, a novel co-activator of HIF1α, promotes tumor initiation in PyMT-induced breast tumor.
BCL7B, a SWI/SNF complex subunit, orchestrates cancer immunity and stemness.
Cytostatic Activity of Sanguinarine and a Cyanide Derivative in Human Erythroleukemia Cells Is Mediated by Suppression of c-MET/MAPK Signaling.
Phosphorylation and stabilization of EZH2 by DCAF1/VprBP trigger aberrant gene silencing in colon cancer.
lncRNA HOTTIP Recruits EZH2 to Inhibit PTEN Expression and Participates in IM Resistance in Chronic Myeloid Leukemia.
Mechanical stretch aggravates vascular smooth muscle cell apoptosis and vascular remodeling by downregulating EZH2.
H3F3A K27M Mutation Promotes the Infiltrative Growth of High-Grade Glioma in Adults by Activating β-Catenin/USP1 Signaling.
Photoaffinity Labeling-Based Chemoproteomic Strategy Reveals RBBP4 as a Cellular Target of Protopanaxadiol against Colorectal Cancer Cells.
Inhibition of Nrf2 degradation alleviates age-related osteoporosis induced by 1,25-Dihydroxyvitamin D deficiency.
A novel FBW7/NFAT1 axis regulates cancer immunity in sunitinib-resistant renal cancer by inducing PD-L1 expression.
Lnc-IL7R alleviates PM(2.5)-mediated cellular senescence and apoptosis through EZH2 recruitment in chronic obstructive pulmonary disease.
MCP-1 facilitates VEGF production by removing miR-374b-5p blocking of VEGF mRNA translation.
PRC2-Mediated Epigenetic Suppression of Type I IFN-STAT2 Signaling Impairs Antitumor Immunity in Luminal Breast Cancer.
Discovery of precision targeting EZH2 degraders for triple-negative breast cancer.
EZH2 Mediates miR-146a-5p/HIF-1α to Alleviate Inflammation and Glycolysis after Acute Spinal Cord Injury.
ZNF750 exerted its Antitumor Action in Oral Squamous Cell Carcinoma by regulating E2F2.
PRMT5 functionally associates with EZH2 to promote colorectal cancer progression through epigenetically repressing CDKN2B expression.
The Role of KDM2B and EZH2 in Regulating the Stemness in Colorectal Cancer Through the PI3K/AKT Pathway.
Hsa_circ_0006232 promotes laryngeal squamous cell cancer progression through FUS-mediated EZH2 stabilization.
Discovery of First-in-Class Dual PARP and EZH2 Inhibitors for Triple-Negative Breast Cancer with Wild-Type BRCA.
Histone acetyltransferase 1 promotes gemcitabine resistance by regulating the PVT1/EZH2 complex in pancreatic cancer.
Single-Cell Analyses Reveal Mechanisms of Cancer Stem Cell Maintenance and Epithelial-Mesenchymal Transition in Recurrent Bladder Cancer.
Overexpression of SERPINA3 promotes tumor invasion and migration, epithelial-mesenchymal-transition in triple-negative breast cancer cells.
lncRNA SNHG7 promotes cell proliferation in glioma by acting as a competing endogenous RNA and sponging miR-138-5p to regulate EZH2 expression.
EZH2 is a potential prognostic predictor of glioma.
Clonal Architectures Predict Clinical Outcome in Gastric Adenocarcinoma Based on Genomic Variation, Tumor Evolution, and Heterogeneity.
EZH2-Inhibited MicroRNA-454-3p Promotes M2 Macrophage Polarization in Glioma.
Expression of EZH2 and P53 and their correlation in ovarian cancer tissues.
miR-137-3p Modulates the Progression of Prostate Cancer by Regulating the JNK3/EZH2 Axis.
Bisphenol a affects endometrial stromal cells decidualization, involvement of epigenetic regulation.
Inhibition of EZH2 attenuates inhibitory synaptic transmission via the pro-inflammatory pathway in rats.
Long noncoding RNA ANRIL promotes the malignant progression of cholangiocarcinoma by epigenetically repressing ERRFI1 expression.
Upregulation of nuclear-enriched abundant transcript 1 confers oxaliplatin resistance to gastric cancer.
1,25-Dihydroxyvitamin D protects against age-related osteoporosis by a novel VDR-Ezh2-p16 signal axis.
BGN/TLR4/NF-B Mediates Epigenetic Silencing of Immunosuppressive Siglec Ligands in Colon Cancer Cells.
Knockdown of long non-coding RNA LINC00467 inhibits glioma cell progression via modulation of E2F3 targeted by miR-200a.
P21 and P27 promote tumorigenesis and progression via cell cycle acceleration in seminal vesicles of TRAMP mice.
Identification and Functional Characterization of a New Splicing Variant of EZH2 in the Central Nervous System.
MDM2 promotes genome instability by ubiquitinating the transcription factor HBP1.
lncRNA TUG1 Promotes Cisplatin Resistance by Regulating CCND2 via Epigenetically Silencing miR-194-5p in Bladder Cancer.
Effect of EZH2 knockdown on preimplantation development of porcine parthenogenetic embryos.
Epigenetic silencing of the synthesis of immunosuppressive Siglec ligand glycans by NF-κB/EZH2/YY1 axis in early-stage colon cancers.
ANLN-induced EZH2 upregulation promotes pancreatic cancer progression by mediating miR-218-5p/LASP1 signaling axis.
Long noncoding RNA DANCR regulates proliferation and migration by epigenetically silencing FBP1 in tumorigenesis of cholangiocarcinoma.
SNHG6 Promotes Tumor Growth via Repression of P21 in Colorectal Cancer.
Long non-coding RNA LINC-01572:28 inhibits granulosa cell growth via a decrease in p27 (Kip1) degradation in patients with polycystic ovary syndrome.
Hypermethylated in cancer 1 (HIC1) mediates high glucose induced ROS accumulation in renal tubular epithelial cells by epigenetically repressing SIRT1 transcription.
Epigenetic silencing of tumor suppressor gene CDKN1A by oncogenic long non-coding RNA SNHG1 in cholangiocarcinoma.
SIRT1 antagonizes liver fibrosis by blocking hepatic stellate cell activation in mice.
VE-Cadherin-Mediated Epigenetic Regulation of Endothelial Gene Expression.
The long non-coding RNA PVT1 represses ANGPTL4 transcription through binding with EZH2 in trophoblast cell.
Carnosol-mediated Sirtuin 1 activation inhibits Enhancer of Zeste Homolog 2 to attenuate liver fibrosis.
Long Non-coding RNA PVT1 Promotes Cell Proliferation and Migration by Silencing ANGPTL4 Expression in Cholangiocarcinoma.
CUL1 promotes breast cancer metastasis through regulating EZH2-induced the autocrine expression of the cytokines CXCL8 and IL11.
LncRNA SOX21-AS1 is associated with progression of hepatocellular carcinoma and predicts prognosis through epigenetically silencing p21.
Upregulation of miR-146a by YY1 depletion correlates with delayed progression of prostate cancer.
Histone Modifications Regulate the Developmental Expression of Human Hepatic UDP-Glucuronosyltransferase 1A1.
Overexpression of CircRNA BCRC4 regulates cell apoptosis and MicroRNA-101/EZH2 signaling in bladder cancer.
CDYL suppresses epileptogenesis in mice through repression of axonal Nav1.6 sodium channel expression.
Post-transcriptional regulation of ERBB2 by miR26a/b and HuR confers resistance to tamoxifen in estrogen receptor-positive breast cancer cells.
lnc-β-Catm elicits EZH2-dependent β-catenin stabilization and sustains liver CSC self-renewal.
HBXIP and LSD1 Scaffolded by lncRNA Hotair Mediate Transcriptional Activation by c-Myc.
Maternal gestational betaine supplementation-mediated suppression of hepatic cyclin D2 and presenilin1 gene in newborn piglets is associated with epigenetic regulation of the STAT3-dependent pathway.
Betaine supplementation in maternal diet modulates the epigenetic regulation of hepatic gluconeogenic genes in neonatal piglets.
A long noncoding RNA Sox2ot regulates lung cancer cell proliferation and is a prognostic indicator of poor survival.
MiR-138 induces renal carcinoma cell senescence by targeting EZH2 and is downregulated in human clear cell renal cell carcinoma.
Xu S, Gong R, Liu S, Wang J, Shen Y, Peng C, Feng Q, Luo M, Lan F, Fan J, Cai J, Lan X
Oncogene 2026 May;45(16):1484-1500
Oncogene 2026 May;45(16):1484-1500
HHV-6A Drives Epigenetic Reprogramming via an EZH2-SIRT1 Axis to Sustain Mutant p53 and Reshape Oncogenic Inflammatory Signaling.
Benedetti R, Di Crosta M, Stirparo A, Aron GA, Mardente S, Santarelli R, Gonnella R, Gilardini Montani MS, Cirone M
Viruses 2026 Mar 26;18(4)
Viruses 2026 Mar 26;18(4)
RG108-Conjugated Platinum(IV) Prodrugs: Enhanced Efficacy and Reduced Ototoxicity.
Wu J, Nie J, Wu H, Wang D, Li Y, Liang M, Qian H, Wang Y
Chemistry (Weinheim an der Bergstrasse, Germany) 2026 Mar 12;:e00019
Chemistry (Weinheim an der Bergstrasse, Germany) 2026 Mar 12;:e00019
Interplay between nuclear survivin and the PRC2 complex and its impact on H3K27me3-directed transcriptional repression.
Vaidya AD, Fezovich AJ, Wheatley SP
Journal of cell science 2026 Jun 15;139(12)
Journal of cell science 2026 Jun 15;139(12)
The PTBP1-EZH2-DOCK2 axis promotes M1 microglial polarization and exacerbates neuronal apoptosis following spinal cord injury.
Sha C, Pan F, Liu X, Wang Z, Dai H, Huang K
Journal of orthopaedic translation 2026 Jan;56:101016
Journal of orthopaedic translation 2026 Jan;56:101016
Mechanically heterogeneous hydrogel with cell-programmed network restructuring promotes tissue regeneration by mechano-epigenetic modulation.
Ling Q, Li H, Zhao J, Guo W, Yu H, Li Z, Hu Y, Wei S, Fu Y, Zhang Y, Zhang K, Bian L
Nature communications 2026 Jan 30;17(1)
Nature communications 2026 Jan 30;17(1)
Neutrophil-derived exosomes inhibit gastric cancer progression via miR-101-3p-mediated suppression of MCL1.
Wang J, Zhang J, Qian Y, Wang Y, Wang S, Fan B, Shi J, Wang J, Meng S, Dong X, Fu M, Zhang X, Ji R, Fang X, Zhang X
Cancer cell international 2026 Jan 21;26(1):88
Cancer cell international 2026 Jan 21;26(1):88
Therapeutic effects of the n-butanol extract of Potentilla freyniana Bornm. in hepatocellular carcinoma cells.
Wang Y, Zhang Z, Cao L, Huang S, Huang X, Zhang Z, Zhang Y, Li X
Journal of ethnopharmacology 2026 Jan 10;354:120492
Journal of ethnopharmacology 2026 Jan 10;354:120492
SA supplementation during lactation promotes learning and memory by reducing H3K27me3 levels.
Huang C, Ai S, Wang M, Li C, Wang K, Nie M, Zhang H, Gu X, Wang HL
Journal of advanced research 2026 Feb;80:301-316
Journal of advanced research 2026 Feb;80:301-316
Characterization of gRNA-dependent and gRNA-independent off-target binding sites of PspCas13b and RfxCas13d in mammalian cells.
Feng H, Li Z, Zhang H, Zheng Y, Xu B, Zhang Y, Zou L, Wu L
Nucleic acids research 2026 Feb 5;54(4)
Nucleic acids research 2026 Feb 5;54(4)
PDGF-BB mitigates pericyte injury by activating the PHF19-PRC2 complex via the miR-221/BRCA1 signaling axis in Alzheimer's disease.
Yang H, Zhou H, Zhao K, Shi L, Li Y, Zhao Q, Ya J, Wu C
Brain research bulletin 2026 Apr;237:111819
Brain research bulletin 2026 Apr;237:111819
Analysis of histone modifications in key cellular subpopulations in the context of azoospermia using spermatogenic single-cell RNA-seq data.
Wang Q, Yang H, Li F, Ge S, Ji L, Li X
Frontiers in bioinformatics 2025;5:1626153
Frontiers in bioinformatics 2025;5:1626153
DEK promotes mammary hyperplasia and is associated with H3K27me3 epigenetic modifications.
Johnstone ME, Leck AL, Lange TE, Wilcher KE, Shephard MS, Paranjpe A, Schutte S, Wells SI, Kappes F, Salomonis N, Privette Vinnedge LM
Life science alliance 2025 Sep;8(9)
Life science alliance 2025 Sep;8(9)
Interplay mechanism of virus latency-reactivation by human cytomegalovirus UL82 protein with the host core histone H3K27 methyltransferase EZH2 of polycomb repressive complex 2.
Huo X, Xia S, Cheng B, Xiong W, Li Q, Yang X, Ran Y, Li H, Chen J
International journal of biological macromolecules 2025 Sep;322(Pt 3):146753
International journal of biological macromolecules 2025 Sep;322(Pt 3):146753
KDM4B modulates ERα signaling pathway to participate in vascular smooth muscle cell calcification.
Liu F, Lv Y, Lin Y, Wang C, Wang S, Zeng K, Zhou B, Lin L, Feng J, Sun G, Chang X, Cao M, Li H, Hu X, Kato S, Zhao Y, Tian W
Cell death discovery 2025 Oct 7;11(1):452
Cell death discovery 2025 Oct 7;11(1):452
EZH2 confers lenvatinib resistance in hepatocellular carcinoma by suppressing ACSL1-Mediated ferroptosis.
Zhang Y, Lin Y, Cai H, Zhou T
BMC cancer 2025 Oct 24;25(1):1638
BMC cancer 2025 Oct 24;25(1):1638
EZH2-mediated downregulation of miR-155-5p contributes to prostate cancer cell malignancy through SMAD2 and TAB2.
Bai ZJ, Liu JY, Xing WZ, Wang HF
The Kaohsiung journal of medical sciences 2025 Mar;41(3):e12936
The Kaohsiung journal of medical sciences 2025 Mar;41(3):e12936
Substrate stiffness modulates osteogenic and adipogenic differentiation of osteosarcoma through PIEZO1 mediated signaling pathway.
Gao Q, Wang M, Hou X, Li M, Li L
Cellular signalling 2025 Mar;127:111601
Cellular signalling 2025 Mar;127:111601
NEAT1 promotes the perineural invasion of pancreatic cancer via the E2F1/GDNF axis.
Gu J, Wang Q, Mo J, Qin T, Qian W, Duan W, Han L, Wang Z, Ma Q, Ma J
Cancer letters 2025 Mar 31;613:217497
Cancer letters 2025 Mar 31;613:217497
Bilateral Synergistic Effects of Phototherapy-Based NIR-II Absorption Photosensitizer for Allergic Rhinitis.
Shao T, Han L, Xie Y, Shi Z, Yang Q, Liu A, Liu Y, Chen L, Huang J, Peng B, Bai H, Chen H, Li L, Bian K
Small (Weinheim an der Bergstrasse, Germany) 2025 Jun;21(22):e2412249
Small (Weinheim an der Bergstrasse, Germany) 2025 Jun;21(22):e2412249
Significant prognostic value of cell-cycle proteins in early-stage small cell carcinoma of cervix.
Xu Q, Zhou H, Wu J, Chang B, Gu Y, Li H, Cheng X
Scientific reports 2025 Jul 24;15(1):26860
Scientific reports 2025 Jul 24;15(1):26860
Modulatory Effect of Curcumin on Expression of Methyltransferase/Demethylase in Colon Cancer Cells: Impact on wt p53, mutp53 and c-Myc.
Santarelli R, Di Dio C, Di Crosta M, Currà P, Gonnella R, Cirone M
Molecules (Basel, Switzerland) 2025 Jul 22;30(15)
Molecules (Basel, Switzerland) 2025 Jul 22;30(15)
SIX1 aggravates the progression of spinal cord injury in mice by promoting M1 polarization of microglia.
Xu Z, Zhu M, Xie H, Zhu J, Zheng H, Liu X, Zhang Y, Liu J
Scientific reports 2025 Jan 8;15(1):1283
Scientific reports 2025 Jan 8;15(1):1283
Changes in Lysine Methylation Contribute to the Cytotoxicity of Curcumin in Colon Cancer Cells.
Santarelli R, Currà P, Di Crosta M, Gonnella R, Gilardini Montani MS, Cirone M
Molecules (Basel, Switzerland) 2025 Jan 16;30(2)
Molecules (Basel, Switzerland) 2025 Jan 16;30(2)
NCAPD3-mediated AKT activation regulates prostate cancer progression.
Zhang Y, Xie W, Zong X, Fang Y, Ren J, Jing Z, Wei Y, Lu S, Zhu Q, Liu P
FASEB bioAdvances 2025 Feb;7(2):e1488
FASEB bioAdvances 2025 Feb;7(2):e1488
Maternal obesity alters histone modifications mediated by the interaction between EZH2 and AMPK, impairing neural differentiation in the developing embryonic brain cortex.
Alawathugoda TT, Sheikh MA, Challagandla AK, Dheen ST, Emerald BS, Ansari SA
The Journal of biological chemistry 2025 Feb;301(2):108173
The Journal of biological chemistry 2025 Feb;301(2):108173
Armadillo domain of ARID1A directly interacts with DNA-PKcs to couple chromatin remodeling with nonhomologous end joining (NHEJ) pathway.
Kanno SI, Kobayashi T, Watanabe R, Kurimasa A, Tanaka K, Yasui A, Ui A
Nucleic acids research 2025 Feb 27;53(5)
Nucleic acids research 2025 Feb 27;53(5)
Mettl3/Eed/Ythdc1 regulatory axis controls endometrial receptivity and function.
Hu X, Li J, Ding C, Jiang J, Xia W, Lu J, Su H, Zhang M, Li H, Liu JL, Lin Y, Meng Q, Huang B
Communications biology 2025 Feb 11;8(1):215
Communications biology 2025 Feb 11;8(1):215
USP44 promotes chemotherapeutic drug resistance of triple negative breast cancer through EZH2 protein stability.
Wu P, Xiao W, Ni J, Lou Y, Xu C
Cancer biology & therapy 2025 Dec;26(1):2529652
Cancer biology & therapy 2025 Dec;26(1):2529652
Association of TP53 and EZH2 with salivary adenoid cystic carcinoma.
Di Y, Zhang H, Zhang B, Li D
Journal of stomatology, oral and maxillofacial surgery 2025 Dec;126(6S):102526
Journal of stomatology, oral and maxillofacial surgery 2025 Dec;126(6S):102526
Therapeutic targeting SPI1 in combination with erastin promotes ferroptosis in ccRCC.
Xue W, Wu Z, Li J, Jin P, Zhu Y, Li Z, Wang Z, Li Z, Fei X
Communications biology 2025 Dec 10;8(1):1772
Communications biology 2025 Dec 10;8(1):1772
Paternal Obesity-Induced H3K27me3 Elevation Leads to MANF-Mediated Transgenerational Metabolic Dysfunction in Female Offspring.
Shi Y, Li W, Yu X, Zhao Y, Zhu D, Song Y, Zhao Z, Gu Y, Wei B, Li L, Yu D, Zhang P, Gao Q, Sun M
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(16):e2415956
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(16):e2415956
SUMO E3 ligase MUL1 inhibits lymph node metastasis of bladder cancer by mediating mitochondrial HSPA9 translocation.
Wu J, Huang M, Dong W, Chen Y, Zhou Q, Zhang Q, Zheng J, Liu Y, Zhang Y, Liu S, Yang C, Chen S, Huang J, Lin T, Chen X
International journal of biological sciences 2024;20(10):3986-4006
International journal of biological sciences 2024;20(10):3986-4006
Potential mechanism of Luoshi Neiyi prescription in endometriosis based on serum pharmacochemistry and network pharmacology.
Wu L, Lin S, Hu Y, Jing S, Sun B, Chen X, Jia J, Zeng C, Pei F
Frontiers in pharmacology 2024;15:1395160
Frontiers in pharmacology 2024;15:1395160
LncRNA FEZF1-AS1 promotes pulmonary fibrosis via up-regulating EZH2 and targeting miR-200c-3p to regulate the ZEB1 pathway.
Liu M, Song L, Lai Y, Gao F, Man J
Scientific reports 2024 Oct 30;14(1):26044
Scientific reports 2024 Oct 30;14(1):26044
VprBP regulates osteoclast differentiation via an epigenetic mechanism involving histone H2A phosphorylation.
Shin Y, Kim S, Choi TI, Kim CH, An W
Epigenetics & chromatin 2024 Nov 26;17(1):35
Epigenetics & chromatin 2024 Nov 26;17(1):35
The in vivo effects of knockdown of long non-coding RNA XIST on fibroid growth and gene expression.
Chuang TD, Ton N, Rysling S, Khorram O
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Nov 15;38(21):e70140
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Nov 15;38(21):e70140
The E3 ubiquitin ligase RNF220 maintains hindbrain Hox expression patterns through regulation of WDR5 stability.
Wang H, Liu X, Liu Y, Yang C, Ye Y, Yu X, Sheng N, Zhang S, Mao B, Ma P
eLife 2024 Nov 11;13
eLife 2024 Nov 11;13
Manganese induces podocyte injury through regulating MTDH/ALKBH5/NLRP10 axis: Combined analysis at epidemiology and molecular biology levels.
Liang Q, Jing J, He H, Huang X, Liu J, Wang M, Qi Z, Zhang L, Huang Z, Yan Y, Liu S, Gao M, Zou Y
Environment international 2024 May;187:108672
Environment international 2024 May;187:108672
Long non-coding RNA HOTAIR: from pan-cancer analysis to colorectal cancer-related uridine metabolism.
Chen X, Wang S, Jiang X, Zhang M, Ding Y
Aging 2024 May 1;16(9):7752-7773
Aging 2024 May 1;16(9):7752-7773
Inhibition of protein kinase C increases Prdm14 level to promote self-renewal of embryonic stem cells through reducing Suv39h-induced H3K9 methylation.
Ji J, Cao J, Chen P, Huang R, Ye SD
The Journal of biological chemistry 2024 Mar;300(3):105714
The Journal of biological chemistry 2024 Mar;300(3):105714
Cell surface CD55 traffics to the nucleus leading to cisplatin resistance and stemness by inducing PRC2 and H3K27 trimethylation on chromatin in ovarian cancer.
Bharti R, Dey G, Khan D, Myers A, Huffman OG, Saygin C, Braley C, Richards E, Sangwan N, Willard B, Lathia JD, Fox PL, Lin F, Jha BK, Brown JM, Yu JS, Dwidar M, Joehlin-Price A, Vargas R, Michener CM, Longworth MS, Reizes O
Molecular cancer 2024 Jun 10;23(1):121
Molecular cancer 2024 Jun 10;23(1):121
EZH2 suppresses ferroptosis in hepatocellular carcinoma and reduces sorafenib sensitivity through epigenetic regulation of TFR2.
Lai Y, Han X, Xie B, Xu Y, Yang Z, Wang D, Li W, Xie Y, Song W, Zhang X, Xia JQ, Zhang P
Cancer science 2024 Jul;115(7):2220-2234
Cancer science 2024 Jul;115(7):2220-2234
The m(6)A reader YTHDC2 regulates UVB-induced DNA damage repair and histone modification.
Yang Z, Verghese M, Yang S, Shah P, He YY
Photochemistry and photobiology 2024 Jul-Aug;100(4):1031-1040
Photochemistry and photobiology 2024 Jul-Aug;100(4):1031-1040
CircARAP2 controls sMICA-induced NK cell desensitization by erasing CTCF/PRC2-induced suppression in early endosome marker RAB5A.
Guo F, Du N, Wen X, Li Z, Guo Y, Zhou L, Hoffman AR, Li L, Hu JF, Cui J
Cellular and molecular life sciences : CMLS 2024 Jul 24;81(1):307
Cellular and molecular life sciences : CMLS 2024 Jul 24;81(1):307
JMJD3 regulate H3K27me3 modification via interacting directly with TET1 to affect spermatogonia self-renewal and proliferation.
Wang J, Liu L, Li Z, Wang H, Ren Y, Wang K, Liu Y, Tao X, Zheng L
BMC genomics 2024 Feb 29;25(1):225
BMC genomics 2024 Feb 29;25(1):225
NIPBL-mediated RAD21 facilitates tumorigenicity by the PI3K pathway in non-small-cell lung cancer.
Xu X, Wang D, Xu W, Li H, Chen N, Li N, Yao Q, Chen W, Zhong J, Mao W
Communications biology 2024 Feb 20;7(1):206
Communications biology 2024 Feb 20;7(1):206
MAPRE3 as an epigenetic target of EZH2 restricts ovarian cancer proliferation in vitro and in vivo.
Zhang Y, Liu F, Zheng J, Jiang K, Ai H, Liu L, Mao D
Experimental cell research 2024 Feb 1;435(1):113913
Experimental cell research 2024 Feb 1;435(1):113913
MAT2A is essential for zygotic genome activation by maintaining of histone methylation in porcine embryos.
Li XH, Lee SH, Lu QY, Zhan CL, Lee GH, Kim JD, Sim JM, Song HJ, Cui XS
Theriogenology 2024 Dec;230:81-90
Theriogenology 2024 Dec;230:81-90
Corynoxine exerts the anti-tumor effect on esophageal squamous cell carcinoma principally via the EZH2-DUSP5-ERK1/2-mediated cell growth inhibition.
Huang G, Xu J, Li Y, Song L, Wen C, Ruan Q, Wen Z, Qi J, Deng J, Liu Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156103
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156103
Luoshi Neiyi Prescription inhibits estradiol synthesis and inflammation in endometriosis through the HIF1A/EZH2/SF-1 pathway.
Wu L, Lan D, Sun B, Su R, Pei F, Kuang Z, Su Y, Lin S, Wang X, Zhang S, Chen X, Jia J, Zeng C
Journal of ethnopharmacology 2024 Dec 5;335:118659
Journal of ethnopharmacology 2024 Dec 5;335:118659
ORC1 enhances repressive epigenetic modifications on HIV-1 LTR to promote HIV-1 latency.
Zhou M, Yang T, Yuan M, Li X, Deng J, Wu S, Zhong Z, Lin Y, Zhang W, Xia B, Wu Y, Wang L, Chen T, Liu R, Pan T, Ma X, Li L, Liu B, Zhang H
Journal of virology 2024 Aug 20;98(8):e0003524
Journal of virology 2024 Aug 20;98(8):e0003524
Iron overload increases the sensitivity of endometriosis stromal cells to ferroptosis via a PRC2-independent function of EZH2.
Luo Y, Li L, Hu Q, Zhang Z, Liu F, Peng Y, Zou Y, Chen L
The international journal of biochemistry & cell biology 2024 Apr;169:106553
The international journal of biochemistry & cell biology 2024 Apr;169:106553
Epigenetic regulation of FOXI2 promotes clear cell renal cell carcinoma progression.
Zhou S, Cheng C, Liao YX, Wang L, Zeng JM, Zhou FF, Zhang XQ, Yang T
Heliyon 2024 Apr 30;10(8):e29218
Heliyon 2024 Apr 30;10(8):e29218
EZH2-dependent epigenetic reprogramming in the central nucleus of amygdala regulates adult anxiety in both sexes after adolescent alcohol exposure.
Bohnsack JP, Zhang H, Pandey SC
Translational psychiatry 2024 Apr 26;14(1):197
Translational psychiatry 2024 Apr 26;14(1):197
LncRNA HOTAIR Enhances Epithelial-to-mesenchymal Transition to Promote the Migration and Invasion of Liver Cancer by Regulating NUAK1 via Epigenetic Inhibition miR-145-5p Expression.
Chu DX, Jin Y, Wang BR, Jiao Y, Zhang CK, Guo ZH, Hu SZ, Li N
Journal of Cancer 2023;14(12):2329-2343
Journal of Cancer 2023;14(12):2329-2343
Cyclohexene oxide CA, a derivative of zeylenone, exhibits anti-cancer activity in glioblastoma by inducing G0/G1 phase arrest through interference with EZH2.
Su R, Cao W, Ma G, Li W, Li Z, Liu Y, Chen L, Chen Z, Li X, Cui P, Huang G
Frontiers in pharmacology 2023;14:1326245
Frontiers in pharmacology 2023;14:1326245
Histone H3K27 methyltransferase EZH2 regulates apoptotic and inflammatory responses in sepsis-induced AKI.
Li B, Xia Y, Mei S, Ye Z, Song B, Yan X, Lin F, Rao T, Yu W, Mei C, Lv J, Wu M, Mao Z, Zhou X, Cheng F
Theranostics 2023;13(6):1860-1875
Theranostics 2023;13(6):1860-1875
Overexpression of RACGAP1 by E2F1 Promotes Neuroendocrine Differentiation of Prostate Cancer by Stabilizing EZH2 Expression.
Song Z, Cao Q, Guo B, Zhao Y, Li X, Lou N, Zhu C, Luo G, Peng S, Li G, Chen K, Wang Y, Ruan H, Guo Y
Aging and disease 2023 Oct 1;14(5):1757-1774
Aging and disease 2023 Oct 1;14(5):1757-1774
Pb inhibited C2C12 myoblast differentiation by regulating HDAC2.
Gu X, Shen N, Huang C, Wang HL
Toxicology 2023 Nov;499:153639
Toxicology 2023 Nov;499:153639
Knockdown of Bach1 protects periodontal bone regeneration from inflammatory damage.
Yuan Z, Li J, Zou X, Liu C, Lu J, Ni C, Tang L, Wu X, Yan F
Journal of cellular and molecular medicine 2023 Nov;27(22):3465-3477
Journal of cellular and molecular medicine 2023 Nov;27(22):3465-3477
EZH2 Gene Knockdown Inhibits Sheep Pituitary Cell Proliferation via Downregulating the AKT/ERK Signaling Pathway.
Cai Y, Chen P, Xu H, Li S, Zhao B, Fan Y, Wang F, Zhang Y
International journal of molecular sciences 2023 Jun 26;24(13)
International journal of molecular sciences 2023 Jun 26;24(13)
Nucleolus assembly impairment leads to two-cell transcriptional repression via NPM1-mediated PRC2 recruitment.
Li D, Cao R, Li Q, Yang Y, Tang A, Zhang J, Liu Q
Nature structural & molecular biology 2023 Jul;30(7):914-925
Nature structural & molecular biology 2023 Jul;30(7):914-925
A targetable MYBL2-ATAD2 axis governs cell proliferation in ovarian cancer.
Liu Q, Liu H, Huang X, Fan X, Xiao Z, Yan R, Yao J, An G, Ge Y, Miao J, Liu J
Cancer gene therapy 2023 Jan;30(1):192-208
Cancer gene therapy 2023 Jan;30(1):192-208
Azithromycin attenuates wheezing after pulmonary inflammation through inhibiting histone H3K27me3 hypermethylation mediated by EZH2.
Wu S, Tian X, Mao Q, Peng C
Clinical epigenetics 2023 Jan 23;15(1):12
Clinical epigenetics 2023 Jan 23;15(1):12
LncRNA H19-EZH2 interaction promotes liver fibrosis via reprogramming H3K27me3 profiles.
Li XJ, Zhou F, Li YJ, Xue XY, Qu JR, Fan GF, Liu J, Sun R, Wu JZ, Zheng Q, Liu RP
Acta pharmacologica Sinica 2023 Dec;44(12):2479-2491
Acta pharmacologica Sinica 2023 Dec;44(12):2479-2491
SND1, a novel co-activator of HIF1α, promotes tumor initiation in PyMT-induced breast tumor.
Hu L, Zeng Y, Xin L, Yang J
The FEBS journal 2023 Dec;290(24):5759-5772
The FEBS journal 2023 Dec;290(24):5759-5772
BCL7B, a SWI/SNF complex subunit, orchestrates cancer immunity and stemness.
Higuchi S, Suehiro Y, Izuhara L, Yoshina S, Hirasawa A, Mitani S
BMC cancer 2023 Aug 30;23(1):811
BMC cancer 2023 Aug 30;23(1):811
Cytostatic Activity of Sanguinarine and a Cyanide Derivative in Human Erythroleukemia Cells Is Mediated by Suppression of c-MET/MAPK Signaling.
Xu X, Deng L, Tang Y, Li J, Zhong T, Hao X, Fan Y, Mu S
International journal of molecular sciences 2023 Apr 30;24(9)
International journal of molecular sciences 2023 Apr 30;24(9)
Phosphorylation and stabilization of EZH2 by DCAF1/VprBP trigger aberrant gene silencing in colon cancer.
Ghate NB, Kim S, Shin Y, Kim J, Doche M, Valena S, Situ A, Kim S, Rhie SK, Lenz HJ, Ulmer TS, Mumenthaler SM, An W
Nature communications 2023 Apr 17;14(1):2140
Nature communications 2023 Apr 17;14(1):2140
lncRNA HOTTIP Recruits EZH2 to Inhibit PTEN Expression and Participates in IM Resistance in Chronic Myeloid Leukemia.
Liu J, Yang L, Liu X, Liu L, Liu M, Feng X, Luo J
Stem cells international 2022;2022:9993393
Stem cells international 2022;2022:9993393
Mechanical stretch aggravates vascular smooth muscle cell apoptosis and vascular remodeling by downregulating EZH2.
Zhong HY, Yuan C, Liu XL, Wang QQ, Li X, Zhao YC, Li X, Liu DD, Zheng TF, Zhang M
The international journal of biochemistry & cell biology 2022 Oct;151:106278
The international journal of biochemistry & cell biology 2022 Oct;151:106278
H3F3A K27M Mutation Promotes the Infiltrative Growth of High-Grade Glioma in Adults by Activating β-Catenin/USP1 Signaling.
Sun Z, Zhu Y, Feng X, Liu X, Zhou K, Wang Q, Zhang H, Shi H
Cancers 2022 Oct 3;14(19)
Cancers 2022 Oct 3;14(19)
Photoaffinity Labeling-Based Chemoproteomic Strategy Reveals RBBP4 as a Cellular Target of Protopanaxadiol against Colorectal Cancer Cells.
Zhuo FF, Guo Q, Zheng YZ, Liu TT, Yang Z, Xu QH, Jiang Y, Liu D, Zeng KW, Tu PF
Chembiochem : a European journal of chemical biology 2022 Jul 5;23(13):e202200038
Chembiochem : a European journal of chemical biology 2022 Jul 5;23(13):e202200038
Inhibition of Nrf2 degradation alleviates age-related osteoporosis induced by 1,25-Dihydroxyvitamin D deficiency.
Yang R, Zhang J, Li J, Qin R, Chen J, Wang R, Goltzman D, Miao D
Free radical biology & medicine 2022 Jan;178:246-261
Free radical biology & medicine 2022 Jan;178:246-261
A novel FBW7/NFAT1 axis regulates cancer immunity in sunitinib-resistant renal cancer by inducing PD-L1 expression.
Liu W, Ren D, Xiong W, Jin X, Zhu L
Journal of experimental & clinical cancer research : CR 2022 Jan 26;41(1):38
Journal of experimental & clinical cancer research : CR 2022 Jan 26;41(1):38
Lnc-IL7R alleviates PM(2.5)-mediated cellular senescence and apoptosis through EZH2 recruitment in chronic obstructive pulmonary disease.
Lee KY, Ho SC, Sun WL, Feng PH, Lin CW, Chen KY, Chuang HC, Tseng CH, Chen TT, Wu SM
Cell biology and toxicology 2022 Dec;38(6):1097-1120
Cell biology and toxicology 2022 Dec;38(6):1097-1120
MCP-1 facilitates VEGF production by removing miR-374b-5p blocking of VEGF mRNA translation.
Zhao HY, Zhu YP, Wen Y, Ding XY, Sun J, Ji RP, Han QJ, Li LY
Biochemical pharmacology 2022 Dec;206:115334
Biochemical pharmacology 2022 Dec;206:115334
PRC2-Mediated Epigenetic Suppression of Type I IFN-STAT2 Signaling Impairs Antitumor Immunity in Luminal Breast Cancer.
Hong J, Lee JH, Zhang Z, Wu Y, Yang M, Liao Y, de la Rosa R, Scheirer J, Pechacek D, Zhang N, Xu Z, Curiel T, Tan X, Huang TH, Xu K
Cancer research 2022 Dec 16;82(24):4624-4640
Cancer research 2022 Dec 16;82(24):4624-4640
Discovery of precision targeting EZH2 degraders for triple-negative breast cancer.
Wang C, Chen X, Liu X, Lu D, Li S, Qu L, Yin F, Luo H, Zhang Y, Luo Z, Cui N, Kong L, Wang X
European journal of medicinal chemistry 2022 Aug 5;238:114462
European journal of medicinal chemistry 2022 Aug 5;238:114462
EZH2 Mediates miR-146a-5p/HIF-1α to Alleviate Inflammation and Glycolysis after Acute Spinal Cord Injury.
Ni S, Yang B, Xia L, Zhang H
Mediators of inflammation 2021;2021:5591582
Mediators of inflammation 2021;2021:5591582
ZNF750 exerted its Antitumor Action in Oral Squamous Cell Carcinoma by regulating E2F2.
Yang HL, Xu C, Yang YK, Tang WQ, Hong M, Pan L, Chen HY
Journal of Cancer 2021;12(24):7266-7276
Journal of Cancer 2021;12(24):7266-7276
PRMT5 functionally associates with EZH2 to promote colorectal cancer progression through epigenetically repressing CDKN2B expression.
Yang L, Ma DW, Cao YP, Li DZ, Zhou X, Feng JF, Bao J
Theranostics 2021;11(8):3742-3759
Theranostics 2021;11(8):3742-3759
The Role of KDM2B and EZH2 in Regulating the Stemness in Colorectal Cancer Through the PI3K/AKT Pathway.
Sanches JGP, Song B, Zhang Q, Cui X, Yabasin IB, Ntim M, Li X, He J, Zhang Y, Mao J, Lu Y, Li L
Frontiers in oncology 2021;11:637298
Frontiers in oncology 2021;11:637298
Hsa_circ_0006232 promotes laryngeal squamous cell cancer progression through FUS-mediated EZH2 stabilization.
Wu T, Wang G, Zeng X, Sun Z, Li S, Wang W, Yu B
Cell cycle (Georgetown, Tex.) 2021 Sep;20(18):1799-1811
Cell cycle (Georgetown, Tex.) 2021 Sep;20(18):1799-1811
Discovery of First-in-Class Dual PARP and EZH2 Inhibitors for Triple-Negative Breast Cancer with Wild-Type BRCA.
Wang C, Qu L, Li S, Yin F, Ji L, Peng W, Luo H, Lu D, Liu X, Chen X, Kong L, Wang X
Journal of medicinal chemistry 2021 Sep 9;64(17):12630-12650
Journal of medicinal chemistry 2021 Sep 9;64(17):12630-12650
Histone acetyltransferase 1 promotes gemcitabine resistance by regulating the PVT1/EZH2 complex in pancreatic cancer.
Sun Y, Ren D, Zhou Y, Shen J, Wu H, Jin X
Cell death & disease 2021 Sep 25;12(10):878
Cell death & disease 2021 Sep 25;12(10):878
Single-Cell Analyses Reveal Mechanisms of Cancer Stem Cell Maintenance and Epithelial-Mesenchymal Transition in Recurrent Bladder Cancer.
Wang H, Mei Y, Luo C, Huang Q, Wang Z, Lu GM, Qin L, Sun Z, Huang CW, Yang ZW, Chen J, Yin W, Qian CN, Zeng J, Chen L, Leng Q, Guo Y, Jia G
Clinical cancer research : an official journal of the American Association for Cancer Research 2021 Nov 15;27(22):6265-6278
Clinical cancer research : an official journal of the American Association for Cancer Research 2021 Nov 15;27(22):6265-6278
Overexpression of SERPINA3 promotes tumor invasion and migration, epithelial-mesenchymal-transition in triple-negative breast cancer cells.
Zhang Y, Tian J, Qu C, Peng Y, Lei J, Li K, Zong B, Sun L, Liu S
Breast cancer (Tokyo, Japan) 2021 Jul;28(4):859-873
Breast cancer (Tokyo, Japan) 2021 Jul;28(4):859-873
lncRNA SNHG7 promotes cell proliferation in glioma by acting as a competing endogenous RNA and sponging miR-138-5p to regulate EZH2 expression.
Deng Y, Cheng L, Lv Z, Zhu H, Meng X
Oncology letters 2021 Jul;22(1):565
Oncology letters 2021 Jul;22(1):565
EZH2 is a potential prognostic predictor of glioma.
Chen YN, Hou SQ, Jiang R, Sun JL, Cheng CD, Qian ZR
Journal of cellular and molecular medicine 2021 Jan;25(2):925-936
Journal of cellular and molecular medicine 2021 Jan;25(2):925-936
Clonal Architectures Predict Clinical Outcome in Gastric Adenocarcinoma Based on Genomic Variation, Tumor Evolution, and Heterogeneity.
Ren C, Wu C, Wang N, Lian C, Yang C
Cell transplantation 2021 Jan-Dec;30:963689721989606
Cell transplantation 2021 Jan-Dec;30:963689721989606
EZH2-Inhibited MicroRNA-454-3p Promotes M2 Macrophage Polarization in Glioma.
Qi B, Yang C, Zhu Z, Chen H
Frontiers in cell and developmental biology 2020;8:574940
Frontiers in cell and developmental biology 2020;8:574940
Expression of EZH2 and P53 and their correlation in ovarian cancer tissues.
Zhai L, Tai WL, Pan YQ, Luo JB, Ma L, Zheng YT, Guo MY, Zhang X
International journal of clinical and experimental pathology 2020;13(3):456-464
International journal of clinical and experimental pathology 2020;13(3):456-464
miR-137-3p Modulates the Progression of Prostate Cancer by Regulating the JNK3/EZH2 Axis.
Zang Y, Zhu J, Li Q, Tu J, Li X, Hu R, Yang D
OncoTargets and therapy 2020;13:7921-7932
OncoTargets and therapy 2020;13:7921-7932
Bisphenol a affects endometrial stromal cells decidualization, involvement of epigenetic regulation.
Xiong Y, Wen X, Liu H, Zhang M, Zhang Y
The Journal of steroid biochemistry and molecular biology 2020 Jun;200:105640
The Journal of steroid biochemistry and molecular biology 2020 Jun;200:105640
Inhibition of EZH2 attenuates inhibitory synaptic transmission via the pro-inflammatory pathway in rats.
Zhang Y, Han Y, Chen Z, Zhao D, Xia Q
Neuropharmacology 2020 Jul;171:108101
Neuropharmacology 2020 Jul;171:108101
Long noncoding RNA ANRIL promotes the malignant progression of cholangiocarcinoma by epigenetically repressing ERRFI1 expression.
Yu Y, Chen Q, Zhang X, Yang J, Lin K, Ji C, Xu A, Yang L, Miao L
Cancer science 2020 Jul;111(7):2297-2309
Cancer science 2020 Jul;111(7):2297-2309
Upregulation of nuclear-enriched abundant transcript 1 confers oxaliplatin resistance to gastric cancer.
Li Y, Peng C, Fang C, Huang K
Cell biology international 2020 Feb;44(2):446-455
Cell biology international 2020 Feb;44(2):446-455
1,25-Dihydroxyvitamin D protects against age-related osteoporosis by a novel VDR-Ezh2-p16 signal axis.
Yang R, Chen J, Zhang J, Qin R, Wang R, Qiu Y, Mao Z, Goltzman D, Miao D
Aging cell 2020 Feb;19(2):e13095
Aging cell 2020 Feb;19(2):e13095
BGN/TLR4/NF-B Mediates Epigenetic Silencing of Immunosuppressive Siglec Ligands in Colon Cancer Cells.
Huang HC, Cai BH, Suen CS, Lee HY, Hwang MJ, Liu FT, Kannagi R
Cells 2020 Feb 9;9(2)
Cells 2020 Feb 9;9(2)
Knockdown of long non-coding RNA LINC00467 inhibits glioma cell progression via modulation of E2F3 targeted by miR-200a.
Gao S, Duan H, An D, Yi X, Li J, Liao C
Cell cycle (Georgetown, Tex.) 2020 Aug;19(16):2040-2053
Cell cycle (Georgetown, Tex.) 2020 Aug;19(16):2040-2053
P21 and P27 promote tumorigenesis and progression via cell cycle acceleration in seminal vesicles of TRAMP mice.
Li T, Wang F, Dang Y, Dong J, Zhang Y, Zhang C, Liu P, Gao Y, Wang X, Yang S, Lu S
International journal of biological sciences 2019;15(10):2198-2210
International journal of biological sciences 2019;15(10):2198-2210
Identification and Functional Characterization of a New Splicing Variant of EZH2 in the Central Nervous System.
Li D, Wang HL, Huang X, Gu X, Xue W, Xu Y
International journal of biological sciences 2019;15(1):69-80
International journal of biological sciences 2019;15(1):69-80
MDM2 promotes genome instability by ubiquitinating the transcription factor HBP1.
Cao Z, Xue J, Cheng Y, Wang J, Liu Y, Li H, Jiang W, Li G, Gui Y, Zhang X
Oncogene 2019 Jun;38(24):4835-4855
Oncogene 2019 Jun;38(24):4835-4855
lncRNA TUG1 Promotes Cisplatin Resistance by Regulating CCND2 via Epigenetically Silencing miR-194-5p in Bladder Cancer.
Yu G, Zhou H, Yao W, Meng L, Lang B
Molecular therapy. Nucleic acids 2019 Jun 7;16:257-271
Molecular therapy. Nucleic acids 2019 Jun 7;16:257-271
Effect of EZH2 knockdown on preimplantation development of porcine parthenogenetic embryos.
Cai Q, Niu H, Zhang B, Shi X, Liao M, Chen Z, Mo D, He Z, Chen Y, Cong P
Theriogenology 2019 Jul 1;132:95-105
Theriogenology 2019 Jul 1;132:95-105
Epigenetic silencing of the synthesis of immunosuppressive Siglec ligand glycans by NF-κB/EZH2/YY1 axis in early-stage colon cancers.
Huang HC, Chao CC, Wu PH, Chung HY, Lee HY, Suen CS, Hwang MJ, Cai BH, Kannagi R
Biochimica et biophysica acta. Gene regulatory mechanisms 2019 Feb;1862(2):173-183
Biochimica et biophysica acta. Gene regulatory mechanisms 2019 Feb;1862(2):173-183
ANLN-induced EZH2 upregulation promotes pancreatic cancer progression by mediating miR-218-5p/LASP1 signaling axis.
Wang A, Dai H, Gong Y, Zhang C, Shu J, Luo Y, Jiang Y, Liu W, Bie P
Journal of experimental & clinical cancer research : CR 2019 Aug 8;38(1):347
Journal of experimental & clinical cancer research : CR 2019 Aug 8;38(1):347
Long noncoding RNA DANCR regulates proliferation and migration by epigenetically silencing FBP1 in tumorigenesis of cholangiocarcinoma.
Wang N, Zhang C, Wang W, Liu J, Yu Y, Li Y, Zhang M, Ge X, Li Q, Miao L
Cell death & disease 2019 Aug 5;10(8):585
Cell death & disease 2019 Aug 5;10(8):585
SNHG6 Promotes Tumor Growth via Repression of P21 in Colorectal Cancer.
Li Z, Qiu R, Qiu X, Tian T
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;49(2):463-478
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;49(2):463-478
Long non-coding RNA LINC-01572:28 inhibits granulosa cell growth via a decrease in p27 (Kip1) degradation in patients with polycystic ovary syndrome.
Zhao J, Xu J, Wang W, Zhao H, Liu H, Liu X, Liu J, Sun Y, Dunaif A, Du Y, Chen ZJ
EBioMedicine 2018 Oct;36:526-538
EBioMedicine 2018 Oct;36:526-538
Hypermethylated in cancer 1 (HIC1) mediates high glucose induced ROS accumulation in renal tubular epithelial cells by epigenetically repressing SIRT1 transcription.
Zeng S, Wu X, Chen X, Xu H, Zhang T, Xu Y
Biochimica et biophysica acta. Gene regulatory mechanisms 2018 Oct;1861(10):917-927
Biochimica et biophysica acta. Gene regulatory mechanisms 2018 Oct;1861(10):917-927
Epigenetic silencing of tumor suppressor gene CDKN1A by oncogenic long non-coding RNA SNHG1 in cholangiocarcinoma.
Yu Y, Zhang M, Wang N, Li Q, Yang J, Yan S, He X, Ji G, Miao L
Cell death & disease 2018 Jul 3;9(7):746
Cell death & disease 2018 Jul 3;9(7):746
SIRT1 antagonizes liver fibrosis by blocking hepatic stellate cell activation in mice.
Li M, Hong W, Hao C, Li L, Wu D, Shen A, Lu J, Zheng Y, Li P, Xu Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Jan;32(1):500-511
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Jan;32(1):500-511
VE-Cadherin-Mediated Epigenetic Regulation of Endothelial Gene Expression.
Morini MF, Giampietro C, Corada M, Pisati F, Lavarone E, Cunha SI, Conze LL, O'Reilly N, Joshi D, Kjaer S, George R, Nye E, Ma A, Jin J, Mitter R, Lupia M, Cavallaro U, Pasini D, Calado DP, Dejana E, Taddei A
Circulation research 2018 Jan 19;122(2):231-245
Circulation research 2018 Jan 19;122(2):231-245
The long non-coding RNA PVT1 represses ANGPTL4 transcription through binding with EZH2 in trophoblast cell.
Xu Y, Lian Y, Zhang Y, Huang S, Zuo Q, Yang N, Chen Y, Wu D, Sun L
Journal of cellular and molecular medicine 2018 Feb;22(2):1272-1282
Journal of cellular and molecular medicine 2018 Feb;22(2):1272-1282
Carnosol-mediated Sirtuin 1 activation inhibits Enhancer of Zeste Homolog 2 to attenuate liver fibrosis.
Zhao H, Wang Z, Tang F, Zhao Y, Feng D, Li Y, Hu Y, Wang C, Zhou J, Tian X, Yao J
Pharmacological research 2018 Feb;128:327-337
Pharmacological research 2018 Feb;128:327-337
Long Non-coding RNA PVT1 Promotes Cell Proliferation and Migration by Silencing ANGPTL4 Expression in Cholangiocarcinoma.
Yu Y, Zhang M, Liu J, Xu B, Yang J, Wang N, Yan S, Wang F, He X, Ji G, Li Q, Miao L
Molecular therapy. Nucleic acids 2018 Dec 7;13:503-513
Molecular therapy. Nucleic acids 2018 Dec 7;13:503-513
CUL1 promotes breast cancer metastasis through regulating EZH2-induced the autocrine expression of the cytokines CXCL8 and IL11.
Huang YF, Zhang Z, Zhang M, Chen YS, Song J, Hou PF, Yong HM, Zheng JN, Bai J
Cell death & disease 2018 Dec 18;10(1):2
Cell death & disease 2018 Dec 18;10(1):2
LncRNA SOX21-AS1 is associated with progression of hepatocellular carcinoma and predicts prognosis through epigenetically silencing p21.
Wei C, Wang H, Xu F, Liu Z, Jiang R
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Aug;104:137-144
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Aug;104:137-144
Upregulation of miR-146a by YY1 depletion correlates with delayed progression of prostate cancer.
Huang Y, Tao T, Liu C, Guan H, Zhang G, Ling Z, Zhang L, Lu K, Chen S, Xu B, Chen M
International journal of oncology 2017 Feb;50(2):421-431
International journal of oncology 2017 Feb;50(2):421-431
Histone Modifications Regulate the Developmental Expression of Human Hepatic UDP-Glucuronosyltransferase 1A1.
Nie YL, Meng XG, Liu JY, Yan L, Wang P, Bi HZ, Kan QC, Zhang LR
Drug metabolism and disposition: the biological fate of chemicals 2017 Dec;45(12):1372-1378
Drug metabolism and disposition: the biological fate of chemicals 2017 Dec;45(12):1372-1378
Overexpression of CircRNA BCRC4 regulates cell apoptosis and MicroRNA-101/EZH2 signaling in bladder cancer.
Li B, Xie F, Zheng FX, Jiang GS, Zeng FQ, Xiao XY
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 2017 Dec;37(6):886-890
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 2017 Dec;37(6):886-890
CDYL suppresses epileptogenesis in mice through repression of axonal Nav1.6 sodium channel expression.
Liu Y, Lai S, Ma W, Ke W, Zhang C, Liu S, Zhang Y, Pei F, Li S, Yi M, Shu Y, Shang Y, Liang J, Huang Z
Nature communications 2017 Aug 25;8(1):355
Nature communications 2017 Aug 25;8(1):355
Post-transcriptional regulation of ERBB2 by miR26a/b and HuR confers resistance to tamoxifen in estrogen receptor-positive breast cancer cells.
Tan S, Ding K, Chong QY, Zhao J, Liu Y, Shao Y, Zhang Y, Yu Q, Xiong Z, Zhang W, Zhang M, Li G, Li X, Kong X, Ahmad A, Wu Z, Wu Q, Zhao X, Lobie PE, Zhu T
The Journal of biological chemistry 2017 Aug 18;292(33):13551-13564
The Journal of biological chemistry 2017 Aug 18;292(33):13551-13564
lnc-β-Catm elicits EZH2-dependent β-catenin stabilization and sustains liver CSC self-renewal.
Zhu P, Wang Y, Huang G, Ye B, Liu B, Wu J, Du Y, He L, Fan Z
Nature structural & molecular biology 2016 Jul;23(7):631-9
Nature structural & molecular biology 2016 Jul;23(7):631-9
HBXIP and LSD1 Scaffolded by lncRNA Hotair Mediate Transcriptional Activation by c-Myc.
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Cancer research 2016 Jan 15;76(2):293-304
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The Journal of nutritional biochemistry 2015 Dec;26(12):1622-31
The Journal of nutritional biochemistry 2015 Dec;26(12):1622-31
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PloS one 2014;9(8):e105504
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The international journal of biochemistry & cell biology 2014 Aug;53:380-8
The international journal of biochemistry & cell biology 2014 Aug;53:380-8
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Oncology research 2013;21(2):83-91
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The EZH2 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human EZH2. This antibody recognizes human, mouse antigen. The EZH2 antibody has been validated for the following applications: ELISA, WB analysis.
