CACNG6

Voltage-dependent calcium channels are composed of five subunits. The protein encoded by this gene represents one of these subunits, gamma, and is one of two known gamma subunit proteins. This particular gamma subunit is an integral membrane protein that is thought to stabilize the calcium channel in an inactive (closed) state. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members that function as transmembrane AMPA receptor regulatory proteins (TARPs). Alternative splicing results in multiple transcript variants. Variants in this gene have been associated with aspirin-intolerant asthma. [provided by RefSeq, Dec 2010]

Description

Calcium voltage-gated channel auxiliary subunit gamma 6

Tissue specificity

Group enriched (skeletal muscle, tongue)

Subcell location

Nucleoli fibrillar center, Cytosol

Predicted location

Membrane

Protein family

FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Transporters

Chromosome

19 (53991637 - 54012666)

Ensembl ID

ENSG00000130433  (ver. 103.38)

Orthologs

Mouse Cacng6: ENSMUSG00000078815

UniProt

Q9BXT2

neXtProt

NX_Q9BXT2

Human splice variants
Mouse splice variants

Protein structure