PTPRK

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation. [provided by RefSeq, Jul 2008]

Description

Protein tyrosine phosphatase receptor type K

Tissue specificity

Low tissue specificity

Subcell location

Vesicles, Plasma membrane, Cell Junctions

Predicted location

Intracellular, Membrane

Protein family

Cancer-related genes
Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

6 (127968785 - 128520616)

Ensembl ID

ENSG00000152894  (ver. 103.38)

Orthologs

Mouse Ptprk: ENSMUSG00000019889

UniProt

Q15262

neXtProt

NX_Q15262

Human splice variants
Mouse splice variants

Protein structure