20182-1-AP

antibody from Proteintech Group

Targeting: FSTL1 FRP, FSL1, OCC-1, OCC1, tsc36

Provider product page for 20182-1-AP

Western blot

ELISA

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [27]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [1]

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Product number: 20182-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#20182-1-AP, RRID:AB_10666439
Product name: FSTL1 antibody
Antibody type: Polyclonal
Description: KD/KO validated FSTL1 antibody (Cat. #20182-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, rat and has been validated for the following applications: IHC, WB,ELISA.
Reactivity: Human, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

FSTL1 protein structure - 20182-1-AP shown in red.

Submitted references High FSTL1 expression promotes bladder cancer progression by enhancing tumor cell migration.

Zhang H, Zhang X, Du Y, Xiong W, Zhang X, Zhang B, Shang P
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2026 Jan;28(1):265-276

Activating the Osteoblastic USP26 Pathway Alleviates Multi-Organ Fibrosis by Decreasing Insulin Resistance.

Tang J, Ye W, He L, Dan Z, Chang L, You Z, Jiang Y, Tang G, Deng L, Li C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(10):e12424

Case-Control Study: Evaluating the Role and Therapeutic Potential of FSTL1 in Type 2 Inflammation of Chronic Rhinosinusitis.

Huang B, Zhu J, Chai X
Journal of inflammation research 2025;18:2545-2556

Quercetin ameliorates epithelial-mesenchymal transition and inflammation by targeting FSTL1 and modulating the NF-κB pathway in pulmonary fibrosis.

Lan Y, Dong C, Wu M, Yuan R, Yang K, Yang Z, Chen Y, Zhang J, Qi B, Lu X
Frontiers in pharmacology 2025;16:1594757

Poliumoside Exhibits Neuroprotective Effects against Cerebral Ischemia-Reperfusion Injury by Relieving Microglia-Mediated Neuronal Damage and Astrocytic Activation.

Bai L, Guan Z, Zhang J, Lv Z, Duan Y, Tian S
ACS chemical neuroscience 2025 May 7;16(9):1780-1791

FSTL1 Can Be a Promising Target in TMJ Osteoarthritis via Regulating Chondrocyte Mitophagy and Apoptosis.

Li F, Qian W, Wang J, Gao M
The Journal of craniofacial surgery 2025 Jun 1;36(4):1401-1407

FSTL1 protects against acute aortic dissection by suppressing vascular smooth muscle cell phenotypic switching and degradation of the extracellular matrix.

Li JP, He WB, Xu SW, Liu JZ, Huang ZQ, Li CP, Huang CL, Mai PB, Geng DF, Qiu XF, Liu ZY, Zhang K, Zhou SX
Journal of molecular and cellular cardiology 2025 Jan;198:60-73

FSTL1 and TLR4 interact with PEDV structural proteins to promote virus adsorption to host cells.

Liu C, Kong N, Liu H, Zhang Y, Qin W, Zhao W, Yang X, Wang Y, Cao X, Liu T, Liu Y, Sun H, Tong W, Yu H, Zheng H, Lan D, Xie S, Tong G, Shan T
Journal of virology 2025 Jan 31;99(1):e0183724

Identification of myokines associated with the pathological stress response in the mdx mouse model of Duchenne muscular dystrophy.

Johnson EE, Powers J, Ervasti JM
Journal of neuromuscular diseases 2025 Dec 23;:22143602251409302

Denosumab attenuates knee osteoarthritis progression by inhibiting synovial inflammation via the RANK/TRAF6/FSTL1 signalling.

Hu Y, Chen W, Lan S, Ming C, Xu D, Li H, Xu H, Shi D, Liu W, Dai Z, Wang J, He Z, Xu W, Shao Z, Liu Y, Tian H, Tong W
Nature communications 2025 Dec 17;16(1):11394

Knockdown of FSTL1 attenuates sepsis-induced acute lung injury by inhibiting inflammation and ferroptosis.

Zhou X, Gao B, Li K, Fu H, Hao Y, Lan A, Zhou F
Molecular immunology 2025 Aug;184:213-223

Human adipose and umbilical cord mesenchymal stem cell-derived extracellular vesicles mitigate photoaging via TIMP1/Notch1.

Zhang H, Xiao X, Wang L, Shi X, Fu N, Wang S, Zhao RC
Signal transduction and targeted therapy 2024 Oct 30;9(1):294

Subchronic co-exposure of polystyrene nanoplastics and 3-BHA significantly aggravated the reproductive toxicity of ovaries and uterus in female mice.

Xiong G, Zhang H, Peng Y, Shi H, Han M, Hu T, Wang H, Zhang S, Wu X, Xu G, Zhang J, Liu Y
Environmental pollution (Barking, Essex : 1987) 2024 Jun 15;351:124101

BMSCs alleviate liver cirrhosis by regulating Fstl1/Wnt/β-Catenin signaling pathway.

Zhangdi H, Geng X, Li N, Xu R, Hu Y, Liu J, Zhang X, Qi J, Tian Y, Qiu J, Huang S, Cang X, Jin S
Heliyon 2023 Nov;9(11):e21010

Skeletal muscle-derived FSTL1 starting up angiogenesis by regulating endothelial junction via activating Src pathway can be upregulated by hydrogen sulfide.

Li MY, Gao RP, Zhu Q, Chen Y, Tao BB, Zhu YC
American journal of physiology. Cell physiology 2023 Nov 1;325(5):C1252-C1266

Prediction of Prognosis and Recurrence of Bladder Cancer by ECM-Related Genes.

Zhao H, Chen Z, Fang Y, Su M, Xu Y, Wang Z, Gyamfi MA, Zhao J
Journal of immunology research 2022;2022:1793005

Single cell analysis reveals inhibition of angiogenesis attenuates the progression of heterotopic ossification in Mkx(-/-) mice.

Lin J, Yang Y, Zhou W, Dai C, Chen X, Xie Y, Han S, Liu H, Hu Y, Tang C, Bunpetch V, Zhang D, Chen Y, Zou X, Chen D, Liu W, Ouyang H
Bone research 2022 Jan 7;10(1):4

Liu F, Zhang J, Zhang D, Qi Q, Cui W, Pan Y, Liu X, Xu J, Qiao X, Wang Z, Dong L
International immunopharmacology 2022 Aug;109:108793

FSTL1 promotes growth and metastasis in gastric cancer by activating AKT related pathway and predicts poor survival.

Wu M, Ding Y, Wu N, Jiang J, Huang Y, Zhang F, Wang H, Zhou Q, Yang Y, Zhuo W, Teng L
American journal of cancer research 2021;11(3):712-728

Mesenchymal stem cells induce tumor stroma formation and epithelial‑mesenchymal transition through SPARC expression in colorectal cancer.

Naito T, Yuge R, Kitadai Y, Takigawa H, Higashi Y, Kuwai T, Kuraoka K, Tanaka S, Chayama K
Oncology reports 2021 Jun;45(6)

Follistatin-like 1 deficiency impairs T cell development to promote lung metastasis of triple negative breast cancer.

Ma J, Yang Y, Wang L, Jia X, Lu T, Zeng Y, Liu L, Gao Y
Aging 2021 Feb 26;13(5):7211-7227

Follistatin-like Protein 1 Inhibits Lung Cancer Metastasis by Preventing Proteolytic Activation of Osteopontin.

Chiou J, Chang YC, Tsai HF, Lin YF, Huang MS, Yang CJ, Hsiao M
Cancer research 2019 Dec 15;79(24):6113-6125

FSTL1 interacts with VIM and promotes colorectal cancer metastasis via activating the focal adhesion signalling pathway.

Gu C, Wang X, Long T, Wang X, Zhong Y, Ma Y, Hu Z, Li Z
Cell death & disease 2018 May 29;9(6):654

EGF hijacks miR-198/FSTL1 wound-healing switch and steers a two-pronged pathway toward metastasis.

Sundaram GM, Ismail HM, Bashir M, Muhuri M, Vaz C, Nama S, Ow GS, Vladimirovna IA, Ramalingam R, Burke B, Tanavde V, Kuznetsov V, Lane EB, Sampath P
The Journal of experimental medicine 2017 Oct 2;214(10):2889-2900

Decrease of FSTL1-BMP4-Smad signaling predicts poor prognosis in lung adenocarcinoma but not in squamous cell carcinoma.

Chiou J, Su CY, Jan YH, Yang CJ, Huang MS, Yu YL, Hsiao M
Scientific reports 2017 Aug 29;7(1):9830

Apical Secretion of FSTL1 in the Respiratory Epithelium for Normal Lung Development.

Li X, Fang Y, Li X, Liang J, Jiang D, Geng Y, Ning W
PloS one 2016;11(6):e0158385

Identification of colonic fibroblast secretomes reveals secretory factors regulating colon cancer cell proliferation.

Chen SX, Xu XE, Wang XQ, Cui SJ, Xu LL, Jiang YH, Zhang Y, Yan HB, Zhang Q, Qiao J, Yang PY, Liu F
Journal of proteomics 2014 Oct 14;110:155-71

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: A2780 cells were subjected to SDS PAGE followed by western blot with 20182-1-AP(FSTL1 antibody) at dilution of 1:300
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The FSTL1 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human FSTL1. This antibody recognizes human,mouse,rat antigen. The FSTL1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 20182-1-AP.pdf

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